-- dump date 20140620_025719 -- class Genbank::misc_feature -- table misc_feature_note -- id note 101510000001 Fic family protein [Function unknown]; Region: COG3177 101510000002 Fic/DOC family; Region: Fic; cl00960 101510000003 classical (c) SDRs; Region: SDR_c; cd05233 101510000004 NAD(P) binding site [chemical binding]; other site 101510000005 active site 101510000006 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510000007 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510000008 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510000009 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510000010 MULE transposase domain; Region: MULE; pfam10551 101510000011 Integrase core domain; Region: rve; pfam00665 101510000012 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 101510000013 AAA ATPase domain; Region: AAA_16; pfam13191 101510000014 AAA domain; Region: AAA_22; pfam13401 101510000015 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 101510000016 catalytic residues [active] 101510000017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 101510000018 Transposase; Region: DDE_Tnp_ISL3; pfam01610 101510000019 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 101510000020 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 101510000021 FAD binding pocket [chemical binding]; other site 101510000022 conserved FAD binding motif [chemical binding]; other site 101510000023 phosphate binding motif [ion binding]; other site 101510000024 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 101510000025 active site 101510000026 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 101510000027 DNA binding site [nucleotide binding] 101510000028 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 101510000029 DNA binding site [nucleotide binding] 101510000030 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 101510000031 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000032 Ligand Binding Site [chemical binding]; other site 101510000033 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000034 Ligand Binding Site [chemical binding]; other site 101510000035 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510000036 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510000037 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510000038 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510000039 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000040 Ligand Binding Site [chemical binding]; other site 101510000041 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000042 Ligand Binding Site [chemical binding]; other site 101510000043 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 101510000044 dimer interface [polypeptide binding]; other site 101510000045 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 101510000046 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000047 Ligand Binding Site [chemical binding]; other site 101510000048 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000049 Ligand Binding Site [chemical binding]; other site 101510000050 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 101510000051 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 101510000052 Walker A/P-loop; other site 101510000053 ATP binding site [chemical binding]; other site 101510000054 Q-loop/lid; other site 101510000055 ABC transporter signature motif; other site 101510000056 Walker B; other site 101510000057 D-loop; other site 101510000058 H-loop/switch region; other site 101510000059 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 101510000060 dimer interface [polypeptide binding]; other site 101510000061 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 101510000062 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 101510000063 nickel binding site [ion binding]; other site 101510000064 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 101510000065 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 101510000066 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 101510000067 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 101510000068 FAD binding pocket [chemical binding]; other site 101510000069 FAD binding motif [chemical binding]; other site 101510000070 phosphate binding motif [ion binding]; other site 101510000071 beta-alpha-beta structure motif; other site 101510000072 NAD binding pocket [chemical binding]; other site 101510000073 Iron coordination center [ion binding]; other site 101510000074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 101510000075 ligand binding site [chemical binding]; other site 101510000076 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 101510000077 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 101510000078 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510000079 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510000080 Glutaminase; Region: Glutaminase; cl00907 101510000081 Short C-terminal domain; Region: SHOCT; pfam09851 101510000082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510000083 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510000084 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000085 Ligand Binding Site [chemical binding]; other site 101510000086 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000087 Ligand Binding Site [chemical binding]; other site 101510000088 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 101510000089 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 101510000090 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 101510000091 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 101510000092 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 101510000093 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 101510000094 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 101510000095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510000096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510000097 active site 101510000098 phosphorylation site [posttranslational modification] 101510000099 intermolecular recognition site; other site 101510000100 dimerization interface [polypeptide binding]; other site 101510000101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510000102 DNA binding residues [nucleotide binding] 101510000103 dimerization interface [polypeptide binding]; other site 101510000104 GAF domain; Region: GAF; pfam01590 101510000105 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 101510000106 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 101510000107 GAF domain; Region: GAF_3; pfam13492 101510000108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510000109 Histidine kinase; Region: HisKA_3; pfam07730 101510000110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510000111 ATP binding site [chemical binding]; other site 101510000112 Mg2+ binding site [ion binding]; other site 101510000113 G-X-G motif; other site 101510000114 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000115 Ligand Binding Site [chemical binding]; other site 101510000116 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000117 Ligand Binding Site [chemical binding]; other site 101510000118 Soluble P-type ATPase [General function prediction only]; Region: COG4087 101510000119 Hemerythrin-like domain; Region: Hr-like; cd12108 101510000120 Fe binding site [ion binding]; other site 101510000121 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 101510000122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 101510000123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510000124 Coenzyme A binding pocket [chemical binding]; other site 101510000125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 101510000126 Predicted kinase [General function prediction only]; Region: COG0645 101510000127 AAA domain; Region: AAA_17; pfam13207 101510000128 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 101510000129 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 101510000130 putative substrate binding site [chemical binding]; other site 101510000131 putative ATP binding site [chemical binding]; other site 101510000132 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 101510000133 active site 101510000134 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 101510000135 active site 101510000136 FOG: CBS domain [General function prediction only]; Region: COG0517 101510000137 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 101510000138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000139 Ligand Binding Site [chemical binding]; other site 101510000140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510000141 Ligand Binding Site [chemical binding]; other site 101510000142 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 101510000143 TrkA-N domain; Region: TrkA_N; pfam02254 101510000144 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 101510000145 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 101510000146 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 101510000147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510000148 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510000149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510000150 active site 101510000151 phosphorylation site [posttranslational modification] 101510000152 intermolecular recognition site; other site 101510000153 dimerization interface [polypeptide binding]; other site 101510000154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510000155 DNA binding site [nucleotide binding] 101510000156 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510000157 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510000158 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510000159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510000160 Condensation domain; Region: Condensation; pfam00668 101510000161 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000162 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510000163 acyl-activating enzyme (AAE) consensus motif; other site 101510000164 AMP binding site [chemical binding]; other site 101510000165 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000166 Condensation domain; Region: Condensation; pfam00668 101510000167 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000168 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510000170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510000171 dimerization interface [polypeptide binding]; other site 101510000172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510000173 dimer interface [polypeptide binding]; other site 101510000174 phosphorylation site [posttranslational modification] 101510000175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510000176 ATP binding site [chemical binding]; other site 101510000177 Mg2+ binding site [ion binding]; other site 101510000178 G-X-G motif; other site 101510000179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510000180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510000181 active site 101510000182 phosphorylation site [posttranslational modification] 101510000183 intermolecular recognition site; other site 101510000184 dimerization interface [polypeptide binding]; other site 101510000185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510000186 DNA binding site [nucleotide binding] 101510000187 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 101510000188 active site 101510000189 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 101510000190 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 101510000191 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510000192 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510000193 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510000194 putative transposase OrfB; Reviewed; Region: PHA02517 101510000195 HTH-like domain; Region: HTH_21; pfam13276 101510000196 Integrase core domain; Region: rve; pfam00665 101510000197 Integrase core domain; Region: rve_3; pfam13683 101510000198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 101510000199 Transposase; Region: HTH_Tnp_1; cl17663 101510000200 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510000201 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510000202 NAD(P) binding site [chemical binding]; other site 101510000203 Domain of unknown function (DUF385); Region: DUF385; cl04387 101510000204 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 101510000205 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510000206 enoyl-CoA hydratase; Provisional; Region: PRK07511 101510000207 substrate binding site [chemical binding]; other site 101510000208 oxyanion hole (OAH) forming residues; other site 101510000209 trimer interface [polypeptide binding]; other site 101510000210 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 101510000211 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510000212 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510000213 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 101510000214 anti sigma factor interaction site; other site 101510000215 regulatory phosphorylation site [posttranslational modification]; other site 101510000216 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 101510000217 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 101510000218 active site 101510000219 homotetramer interface [polypeptide binding]; other site 101510000220 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 101510000221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510000222 putative ADP-binding pocket [chemical binding]; other site 101510000223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510000224 GAF domain; Region: GAF; pfam01590 101510000225 ANTAR domain; Region: ANTAR; pfam03861 101510000226 Predicted membrane protein [Function unknown]; Region: COG4129 101510000227 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 101510000228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510000229 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 101510000230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510000231 DNA binding residues [nucleotide binding] 101510000232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 101510000233 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 101510000234 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 101510000235 DNA-binding site [nucleotide binding]; DNA binding site 101510000236 RNA-binding motif; other site 101510000237 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 101510000238 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 101510000239 dimerization interface [polypeptide binding]; other site 101510000240 DPS ferroxidase diiron center [ion binding]; other site 101510000241 ion pore; other site 101510000242 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 101510000243 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 101510000244 Protein of unknown function (DUF664); Region: DUF664; pfam04978 101510000245 DinB superfamily; Region: DinB_2; pfam12867 101510000246 Cutinase; Region: Cutinase; pfam01083 101510000247 GAF domain; Region: GAF_2; pfam13185 101510000248 ANTAR domain; Region: ANTAR; pfam03861 101510000249 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 101510000250 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 101510000251 anti sigma factor interaction site; other site 101510000252 regulatory phosphorylation site [posttranslational modification]; other site 101510000253 YCII-related domain; Region: YCII; cl00999 101510000254 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 101510000255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510000256 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 101510000257 multiple promoter invertase; Provisional; Region: mpi; PRK13413 101510000258 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510000259 catalytic residues [active] 101510000260 catalytic nucleophile [active] 101510000261 Presynaptic Site I dimer interface [polypeptide binding]; other site 101510000262 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 101510000263 Synaptic Flat tetramer interface [polypeptide binding]; other site 101510000264 Synaptic Site I dimer interface [polypeptide binding]; other site 101510000265 DNA binding site [nucleotide binding] 101510000266 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 101510000267 DNA-binding interface [nucleotide binding]; DNA binding site 101510000268 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 101510000269 LGFP repeat; Region: LGFP; pfam08310 101510000270 LGFP repeat; Region: LGFP; pfam08310 101510000271 LGFP repeat; Region: LGFP; pfam08310 101510000272 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 101510000273 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 101510000274 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 101510000275 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 101510000276 oligomer interface [polypeptide binding]; other site 101510000277 metal binding site [ion binding]; metal-binding site 101510000278 metal binding site [ion binding]; metal-binding site 101510000279 putative Cl binding site [ion binding]; other site 101510000280 aspartate ring; other site 101510000281 basic sphincter; other site 101510000282 hydrophobic gate; other site 101510000283 periplasmic entrance; other site 101510000284 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 101510000285 hydroxyglutarate oxidase; Provisional; Region: PRK11728 101510000286 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 101510000287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510000288 motif II; other site 101510000289 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510000290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510000291 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 101510000292 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 101510000293 PhoU domain; Region: PhoU; pfam01895 101510000294 PhoU domain; Region: PhoU; pfam01895 101510000295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510000296 S-adenosylmethionine binding site [chemical binding]; other site 101510000297 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 101510000298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510000299 active site 101510000300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510000301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510000302 active site 101510000303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510000304 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 101510000305 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510000306 catalytic loop [active] 101510000307 iron binding site [ion binding]; other site 101510000308 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 101510000309 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 101510000310 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 101510000311 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 101510000312 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 101510000313 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 101510000314 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 101510000315 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510000316 Predicted ATPase [General function prediction only]; Region: COG3903 101510000317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510000318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510000319 DNA binding residues [nucleotide binding] 101510000320 dimerization interface [polypeptide binding]; other site 101510000321 oxidoreductase; Provisional; Region: PRK12743 101510000322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510000323 NAD(P) binding site [chemical binding]; other site 101510000324 Secretory lipase; Region: LIP; pfam03583 101510000325 Condensation domain; Region: Condensation; pfam00668 101510000326 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000327 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000328 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000329 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510000330 acyl-activating enzyme (AAE) consensus motif; other site 101510000331 AMP binding site [chemical binding]; other site 101510000332 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000333 Condensation domain; Region: Condensation; pfam00668 101510000334 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000335 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000336 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000337 acyl-activating enzyme (AAE) consensus motif; other site 101510000338 AMP binding site [chemical binding]; other site 101510000339 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000340 peptide synthase; Provisional; Region: PRK12316 101510000341 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000342 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000343 acyl-activating enzyme (AAE) consensus motif; other site 101510000344 AMP binding site [chemical binding]; other site 101510000345 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000346 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510000347 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000348 acyl-activating enzyme (AAE) consensus motif; other site 101510000349 AMP binding site [chemical binding]; other site 101510000350 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000351 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000352 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000353 acyl-activating enzyme (AAE) consensus motif; other site 101510000354 AMP binding site [chemical binding]; other site 101510000355 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000356 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510000357 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000358 acyl-activating enzyme (AAE) consensus motif; other site 101510000359 AMP binding site [chemical binding]; other site 101510000360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000361 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510000362 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000363 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000364 acyl-activating enzyme (AAE) consensus motif; other site 101510000365 AMP binding site [chemical binding]; other site 101510000366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000367 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 101510000368 Condensation domain; Region: Condensation; pfam00668 101510000369 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000370 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510000371 acyl-activating enzyme (AAE) consensus motif; other site 101510000372 AMP binding site [chemical binding]; other site 101510000373 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000374 peptide synthase; Provisional; Region: PRK12467 101510000375 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000376 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000377 acyl-activating enzyme (AAE) consensus motif; other site 101510000378 AMP binding site [chemical binding]; other site 101510000379 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000380 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000381 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000382 acyl-activating enzyme (AAE) consensus motif; other site 101510000383 AMP binding site [chemical binding]; other site 101510000384 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000385 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510000386 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000387 acyl-activating enzyme (AAE) consensus motif; other site 101510000388 AMP binding site [chemical binding]; other site 101510000389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000390 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000391 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000392 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000393 acyl-activating enzyme (AAE) consensus motif; other site 101510000394 AMP binding site [chemical binding]; other site 101510000395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000396 Condensation domain; Region: Condensation; pfam00668 101510000397 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000398 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000399 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000400 acyl-activating enzyme (AAE) consensus motif; other site 101510000401 AMP binding site [chemical binding]; other site 101510000402 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000403 Condensation domain; Region: Condensation; pfam00668 101510000404 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000405 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000406 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000407 acyl-activating enzyme (AAE) consensus motif; other site 101510000408 AMP binding site [chemical binding]; other site 101510000409 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000410 Condensation domain; Region: Condensation; pfam00668 101510000411 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000412 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000413 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000414 acyl-activating enzyme (AAE) consensus motif; other site 101510000415 AMP binding site [chemical binding]; other site 101510000416 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000417 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510000418 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000419 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000420 acyl-activating enzyme (AAE) consensus motif; other site 101510000421 AMP binding site [chemical binding]; other site 101510000422 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000423 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 101510000424 Ligand binding site; other site 101510000425 Putative Catalytic site; other site 101510000426 DXD motif; other site 101510000427 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 101510000428 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 101510000429 putative active site [active] 101510000430 catalytic triad [active] 101510000431 putative dimer interface [polypeptide binding]; other site 101510000432 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510000433 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510000434 active site 101510000435 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 101510000436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510000437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510000438 active site 101510000439 phosphorylation site [posttranslational modification] 101510000440 intermolecular recognition site; other site 101510000441 dimerization interface [polypeptide binding]; other site 101510000442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510000443 DNA binding residues [nucleotide binding] 101510000444 dimerization interface [polypeptide binding]; other site 101510000445 FOG: CBS domain [General function prediction only]; Region: COG0517 101510000446 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 101510000447 lysine-ketoglutarate reductase/saccharopine dehydrogenase; Region: PLN02819 101510000448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 101510000449 PAS domain; Region: PAS_9; pfam13426 101510000450 putative active site [active] 101510000451 heme pocket [chemical binding]; other site 101510000452 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510000453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510000454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510000455 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510000456 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510000457 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510000458 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 101510000459 active site 101510000460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510000461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510000462 Histidine kinase; Region: HisKA_3; pfam07730 101510000463 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 101510000464 hypothetical protein; Provisional; Region: PRK10621 101510000465 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510000466 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 101510000467 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 101510000468 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510000469 Protein of unknown function (DUF418); Region: DUF418; cl12135 101510000470 Protein of unknown function (DUF418); Region: DUF418; cl12135 101510000471 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 101510000472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510000473 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510000474 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 101510000475 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 101510000476 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 101510000477 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 101510000478 precorrin-3B synthase; Region: CobG; TIGR02435 101510000479 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 101510000480 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 101510000481 Precorrin-8X methylmutase; Region: CbiC; pfam02570 101510000482 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 101510000483 active site 101510000484 SAM binding site [chemical binding]; other site 101510000485 homodimer interface [polypeptide binding]; other site 101510000486 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 101510000487 active site 101510000488 SAM binding site [chemical binding]; other site 101510000489 homodimer interface [polypeptide binding]; other site 101510000490 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 101510000491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510000492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510000493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510000494 dimerization interface [polypeptide binding]; other site 101510000495 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 101510000496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510000497 NADH(P)-binding; Region: NAD_binding_10; pfam13460 101510000498 NAD(P) binding site [chemical binding]; other site 101510000499 active site 101510000500 Predicted transcriptional regulator [Transcription]; Region: COG1959 101510000501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510000502 dimerization interface [polypeptide binding]; other site 101510000503 putative Zn2+ binding site [ion binding]; other site 101510000504 putative DNA binding site [nucleotide binding]; other site 101510000505 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 101510000506 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 101510000507 DNA binding residues [nucleotide binding] 101510000508 dimer interface [polypeptide binding]; other site 101510000509 [2Fe-2S] cluster binding site [ion binding]; other site 101510000510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510000511 putative substrate translocation pore; other site 101510000512 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510000513 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 101510000514 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510000515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510000516 DNA binding residues [nucleotide binding] 101510000517 dimerization interface [polypeptide binding]; other site 101510000518 acyl-CoA synthetase; Validated; Region: PRK08162 101510000519 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 101510000520 acyl-activating enzyme (AAE) consensus motif; other site 101510000521 putative active site [active] 101510000522 AMP binding site [chemical binding]; other site 101510000523 putative CoA binding site [chemical binding]; other site 101510000524 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 101510000525 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 101510000526 Chorismate mutase type II; Region: CM_2; cl00693 101510000527 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 101510000528 Predicted membrane protein [Function unknown]; Region: COG2259 101510000529 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 101510000530 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510000531 RNA polymerase factor sigma-70; Validated; Region: PRK08241 101510000532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510000533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510000534 DNA binding residues [nucleotide binding] 101510000535 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510000536 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 101510000537 Strictosidine synthase; Region: Str_synth; pfam03088 101510000538 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510000539 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510000540 Cupin domain; Region: Cupin_2; cl17218 101510000541 Cupin; Region: Cupin_1; smart00835 101510000542 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 101510000543 putative hydrophobic ligand binding site [chemical binding]; other site 101510000544 Gas vesicle protein; Region: Gas_vesicle; cl02954 101510000545 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 101510000546 Gas vesicle protein G; Region: GvpG; pfam05120 101510000547 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 101510000548 Gas vesicle protein; Region: Gas_vesicle; pfam00741 101510000549 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 101510000550 Gas vesicle protein K; Region: GvpK; pfam05121 101510000551 CsbD-like; Region: CsbD; cl17424 101510000552 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 101510000553 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 101510000554 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 101510000555 classical (c) SDRs; Region: SDR_c; cd05233 101510000556 NAD(P) binding site [chemical binding]; other site 101510000557 active site 101510000558 tellurite resistance protein TehB; Provisional; Region: PRK11207 101510000559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510000560 S-adenosylmethionine binding site [chemical binding]; other site 101510000561 putative oxidoreductase; Provisional; Region: PRK11579 101510000562 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510000563 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510000564 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510000565 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 101510000566 DNA binding residues [nucleotide binding] 101510000567 putative dimer interface [polypeptide binding]; other site 101510000568 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 101510000569 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510000570 DNA binding residues [nucleotide binding] 101510000571 putative dimer interface [polypeptide binding]; other site 101510000572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510000573 S-adenosylmethionine binding site [chemical binding]; other site 101510000574 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510000575 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 101510000576 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 101510000577 putative ligand binding site [chemical binding]; other site 101510000578 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510000579 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510000580 substrate binding pocket [chemical binding]; other site 101510000581 membrane-bound complex binding site; other site 101510000582 hinge residues; other site 101510000583 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 101510000584 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 101510000585 Condensation domain; Region: Condensation; pfam00668 101510000586 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000587 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000588 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510000589 acyl-activating enzyme (AAE) consensus motif; other site 101510000590 AMP binding site [chemical binding]; other site 101510000591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000592 Condensation domain; Region: Condensation; pfam00668 101510000593 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000594 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000595 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000596 acyl-activating enzyme (AAE) consensus motif; other site 101510000597 AMP binding site [chemical binding]; other site 101510000598 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000599 Condensation domain; Region: Condensation; pfam00668 101510000600 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000601 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000602 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000603 acyl-activating enzyme (AAE) consensus motif; other site 101510000604 AMP binding site [chemical binding]; other site 101510000605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000606 Condensation domain; Region: Condensation; pfam00668 101510000607 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510000608 Condensation domain; Region: Condensation; pfam00668 101510000609 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000610 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510000611 acyl-activating enzyme (AAE) consensus motif; other site 101510000612 AMP binding site [chemical binding]; other site 101510000613 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000614 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000615 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000616 acyl-activating enzyme (AAE) consensus motif; other site 101510000617 AMP binding site [chemical binding]; other site 101510000618 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000619 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510000620 Condensation domain; Region: Condensation; pfam00668 101510000621 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000622 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510000623 acyl-activating enzyme (AAE) consensus motif; other site 101510000624 AMP binding site [chemical binding]; other site 101510000625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000626 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510000627 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510000628 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000629 acyl-activating enzyme (AAE) consensus motif; other site 101510000630 AMP binding site [chemical binding]; other site 101510000631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000632 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 101510000633 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510000634 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510000635 acyl-activating enzyme (AAE) consensus motif; other site 101510000636 AMP binding site [chemical binding]; other site 101510000637 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510000638 classical (c) SDRs; Region: SDR_c; cd05233 101510000639 NAD(P) binding site [chemical binding]; other site 101510000640 active site 101510000641 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 101510000642 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 101510000643 nucleophilic elbow; other site 101510000644 catalytic triad; other site 101510000645 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 101510000646 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 101510000647 active site 101510000648 DNA binding site [nucleotide binding] 101510000649 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 101510000650 DNA binding site [nucleotide binding] 101510000651 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 101510000652 nudix motif; other site 101510000653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510000654 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510000655 active site 101510000656 catalytic tetrad [active] 101510000657 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 101510000658 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 101510000659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510000660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510000661 oxidoreductase; Provisional; Region: PRK06128 101510000662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510000663 NAD(P) binding site [chemical binding]; other site 101510000664 active site 101510000665 Clp amino terminal domain; Region: Clp_N; pfam02861 101510000666 Transcriptional regulator PadR-like family; Region: PadR; cl17335 101510000667 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510000668 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 101510000669 rod shape-determining protein MreB; Provisional; Region: PRK13930 101510000670 MreB and similar proteins; Region: MreB_like; cd10225 101510000671 nucleotide binding site [chemical binding]; other site 101510000672 Mg binding site [ion binding]; other site 101510000673 putative protofilament interaction site [polypeptide binding]; other site 101510000674 RodZ interaction site [polypeptide binding]; other site 101510000675 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 101510000676 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 101510000677 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 101510000678 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 101510000679 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 101510000680 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 101510000681 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510000682 FAD binding domain; Region: FAD_binding_4; pfam01565 101510000683 Berberine and berberine like; Region: BBE; pfam08031 101510000684 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510000685 active site 101510000686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510000687 active site 101510000688 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 101510000689 hypothetical protein; Validated; Region: PRK07198 101510000690 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 101510000691 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 101510000692 dimerization interface [polypeptide binding]; other site 101510000693 active site 101510000694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 101510000695 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 101510000696 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 101510000697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510000698 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 101510000699 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 101510000700 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510000701 Transcriptional regulator PadR-like family; Region: PadR; cl17335 101510000702 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 101510000703 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 101510000704 OsmC-like protein; Region: OsmC; pfam02566 101510000705 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510000706 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510000707 active site 101510000708 non-prolyl cis peptide bond; other site 101510000709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510000710 substrate binding pocket [chemical binding]; other site 101510000711 membrane-bound complex binding site; other site 101510000712 hinge residues; other site 101510000713 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510000714 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 101510000715 Walker A/P-loop; other site 101510000716 ATP binding site [chemical binding]; other site 101510000717 Q-loop/lid; other site 101510000718 ABC transporter signature motif; other site 101510000719 Walker B; other site 101510000720 D-loop; other site 101510000721 H-loop/switch region; other site 101510000722 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510000723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510000724 dimer interface [polypeptide binding]; other site 101510000725 conserved gate region; other site 101510000726 putative PBP binding loops; other site 101510000727 ABC-ATPase subunit interface; other site 101510000728 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510000729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510000730 DNA-binding site [nucleotide binding]; DNA binding site 101510000731 FCD domain; Region: FCD; pfam07729 101510000732 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 101510000733 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 101510000734 active site 101510000735 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 101510000736 Protein of unknown function (DUF867); Region: DUF867; cl01713 101510000737 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 101510000738 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510000739 active site 101510000740 ATP binding site [chemical binding]; other site 101510000741 substrate binding site [chemical binding]; other site 101510000742 activation loop (A-loop); other site 101510000743 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 101510000744 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 101510000745 putative active site [active] 101510000746 putative metal binding site [ion binding]; other site 101510000747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510000748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510000749 active site 101510000750 ATP binding site [chemical binding]; other site 101510000751 substrate binding site [chemical binding]; other site 101510000752 activation loop (A-loop); other site 101510000753 Kelch motif; Region: Kelch_1; pfam01344 101510000754 Kelch domain; Region: Kelch; smart00612 101510000755 Kelch motif; Region: Kelch_1; pfam01344 101510000756 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 101510000757 Kelch motif; Region: Kelch_1; pfam01344 101510000758 Kelch motif; Region: Kelch_1; pfam01344 101510000759 Kelch domain; Region: Kelch; smart00612 101510000760 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 101510000761 Kelch motif; Region: Kelch_1; pfam01344 101510000762 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 101510000763 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510000764 I-site; other site 101510000765 active site 101510000766 metal binding site [ion binding]; metal-binding site 101510000767 TOBE domain; Region: TOBE; cl01440 101510000768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510000769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510000770 ATP binding site [chemical binding]; other site 101510000771 Mg2+ binding site [ion binding]; other site 101510000772 G-X-G motif; other site 101510000773 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 101510000774 putative catalytic site [active] 101510000775 putative metal binding site [ion binding]; other site 101510000776 putative phosphate binding site [ion binding]; other site 101510000777 Uncharacterized conserved protein [Function unknown]; Region: COG5276 101510000778 Domain of unknown function (DUF305); Region: DUF305; pfam03713 101510000779 classical (c) SDRs; Region: SDR_c; cd05233 101510000780 short chain dehydrogenase; Provisional; Region: PRK07041 101510000781 NAD(P) binding site [chemical binding]; other site 101510000782 active site 101510000783 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510000784 active site 101510000785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510000786 Helicase associated domain; Region: HA; pfam03457 101510000787 Helicase associated domain; Region: HA; pfam03457 101510000788 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 101510000789 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 101510000790 conserved cys residue [active] 101510000791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510000792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510000793 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 101510000794 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 101510000795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510000796 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510000797 putative substrate translocation pore; other site 101510000798 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510000799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510000800 DNA-binding site [nucleotide binding]; DNA binding site 101510000801 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 101510000802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510000803 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510000804 active site 101510000805 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510000806 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510000807 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510000808 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510000809 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 101510000810 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 101510000811 putative active site [active] 101510000812 putative catalytic site [active] 101510000813 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510000814 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 101510000815 NAD(P) binding site [chemical binding]; other site 101510000816 catalytic residues [active] 101510000817 catalytic residues [active] 101510000818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 101510000819 Transposase; Region: HTH_Tnp_1; cl17663 101510000820 putative transposase OrfB; Reviewed; Region: PHA02517 101510000821 HTH-like domain; Region: HTH_21; pfam13276 101510000822 Integrase core domain; Region: rve; pfam00665 101510000823 Integrase core domain; Region: rve_3; pfam13683 101510000824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510000825 oxyanion hole (OAH) forming residues; other site 101510000826 trimer interface [polypeptide binding]; other site 101510000827 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 101510000828 Integrase core domain; Region: rve; pfam00665 101510000829 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 101510000830 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 101510000831 tetramer interface [polypeptide binding]; other site 101510000832 active site 101510000833 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510000834 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510000835 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510000836 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510000837 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510000838 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510000839 CoenzymeA binding site [chemical binding]; other site 101510000840 subunit interaction site [polypeptide binding]; other site 101510000841 PHB binding site; other site 101510000842 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510000843 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 101510000844 tartrate dehydrogenase; Region: TTC; TIGR02089 101510000845 putative DNA binding site [nucleotide binding]; other site 101510000846 dimerization interface [polypeptide binding]; other site 101510000847 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 101510000848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510000849 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510000850 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510000851 NAD(P) binding site [chemical binding]; other site 101510000852 MarR family; Region: MarR_2; cl17246 101510000853 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510000854 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 101510000855 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 101510000856 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 101510000857 active site residue [active] 101510000858 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 101510000859 active site residue [active] 101510000860 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 101510000861 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 101510000862 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 101510000863 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510000864 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 101510000865 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 101510000866 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 101510000867 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510000868 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 101510000869 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 101510000870 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 101510000871 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 101510000872 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 101510000873 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 101510000874 NAD(P) binding site [chemical binding]; other site 101510000875 aldehyde dehydrogenase family 7 member; Region: PLN02315 101510000876 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 101510000877 tetrameric interface [polypeptide binding]; other site 101510000878 NAD binding site [chemical binding]; other site 101510000879 catalytic residues [active] 101510000880 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 101510000881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 101510000882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510000883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510000884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510000885 dimerization interface [polypeptide binding]; other site 101510000886 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510000887 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510000888 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510000889 FAD binding domain; Region: FAD_binding_4; pfam01565 101510000890 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 101510000891 Cysteine-rich domain; Region: CCG; pfam02754 101510000892 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510000893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510000894 DNA-binding site [nucleotide binding]; DNA binding site 101510000895 FCD domain; Region: FCD; pfam07729 101510000896 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510000897 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 101510000898 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 101510000899 Glutamate binding site [chemical binding]; other site 101510000900 NAD binding site [chemical binding]; other site 101510000901 catalytic residues [active] 101510000902 Proline dehydrogenase; Region: Pro_dh; cl03282 101510000903 Protein of unknown function (DUF421); Region: DUF421; pfam04239 101510000904 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 101510000905 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510000906 active site 101510000907 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510000908 TIGR03086 family protein; Region: TIGR03086 101510000909 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 101510000910 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 101510000911 coenzyme A binding site [chemical binding]; other site 101510000912 citrylCoA binding site [chemical binding]; other site 101510000913 oxalacetate binding site [chemical binding]; other site 101510000914 catalytic triad [active] 101510000915 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 101510000916 Cupin domain; Region: Cupin_2; cl17218 101510000917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510000918 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 101510000919 amidase; Provisional; Region: PRK07235 101510000920 indole acetimide hydrolase; Validated; Region: PRK07488 101510000921 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 101510000922 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 101510000923 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 101510000924 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 101510000925 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 101510000926 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 101510000927 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 101510000928 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 101510000929 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510000930 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510000931 enoyl-CoA hydratase; Provisional; Region: PRK08260 101510000932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510000933 substrate binding site [chemical binding]; other site 101510000934 oxyanion hole (OAH) forming residues; other site 101510000935 trimer interface [polypeptide binding]; other site 101510000936 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 101510000937 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510000938 acyl-activating enzyme (AAE) consensus motif; other site 101510000939 AMP binding site [chemical binding]; other site 101510000940 active site 101510000941 CoA binding site [chemical binding]; other site 101510000942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510000943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510000944 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510000945 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510000946 FMN-binding pocket [chemical binding]; other site 101510000947 flavin binding motif; other site 101510000948 phosphate binding motif [ion binding]; other site 101510000949 beta-alpha-beta structure motif; other site 101510000950 NAD binding pocket [chemical binding]; other site 101510000951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510000952 catalytic loop [active] 101510000953 iron binding site [ion binding]; other site 101510000954 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 101510000955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510000956 NAD(P) binding site [chemical binding]; other site 101510000957 active site 101510000958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510000959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510000960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510000961 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510000962 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 101510000963 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510000964 NAD binding site [chemical binding]; other site 101510000965 catalytic residues [active] 101510000966 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510000967 classical (c) SDRs; Region: SDR_c; cd05233 101510000968 NAD(P) binding site [chemical binding]; other site 101510000969 active site 101510000970 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 101510000971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510000972 Coenzyme A binding pocket [chemical binding]; other site 101510000973 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510000974 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 101510000975 [2Fe-2S] cluster binding site [ion binding]; other site 101510000976 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 101510000977 putative alpha subunit interface [polypeptide binding]; other site 101510000978 putative active site [active] 101510000979 putative substrate binding site [chemical binding]; other site 101510000980 Fe binding site [ion binding]; other site 101510000981 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510000982 Cytochrome P450; Region: p450; cl12078 101510000983 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 101510000984 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 101510000985 classical (c) SDRs; Region: SDR_c; cd05233 101510000986 NAD(P) binding site [chemical binding]; other site 101510000987 active site 101510000988 Bacterial Na+/H+ antiporter B (NhaB); Region: NhaB; cl17323 101510000989 benzoate transport; Region: 2A0115; TIGR00895 101510000990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510000991 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510000992 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 101510000993 [2Fe-2S] cluster binding site [ion binding]; other site 101510000994 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 101510000995 putative alpha subunit interface [polypeptide binding]; other site 101510000996 putative active site [active] 101510000997 putative substrate binding site [chemical binding]; other site 101510000998 Fe binding site [ion binding]; other site 101510000999 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 101510001000 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510001001 NAD binding site [chemical binding]; other site 101510001002 catalytic residues [active] 101510001003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510001004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510001005 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510001006 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 101510001007 lipid-transfer protein; Provisional; Region: PRK07855 101510001008 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510001009 active site 101510001010 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 101510001011 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510001012 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510001013 classical (c) SDRs; Region: SDR_c; cd05233 101510001014 NAD(P) binding site [chemical binding]; other site 101510001015 active site 101510001016 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510001017 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 101510001018 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510001019 Cytochrome P450; Region: p450; cl12078 101510001020 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510001021 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510001022 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510001023 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510001024 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 101510001025 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510001026 NAD binding site [chemical binding]; other site 101510001027 catalytic residues [active] 101510001028 lipid-transfer protein; Provisional; Region: PRK07855 101510001029 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510001030 active site 101510001031 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 101510001032 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510001033 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 101510001034 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510001035 active site 101510001036 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510001037 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 101510001038 enoyl-CoA hydratase; Provisional; Region: PRK05864 101510001039 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510001040 substrate binding site [chemical binding]; other site 101510001041 oxyanion hole (OAH) forming residues; other site 101510001042 trimer interface [polypeptide binding]; other site 101510001043 short chain dehydrogenase; Provisional; Region: PRK08265 101510001044 secoisolariciresinol dehydrogenase (secoisolariciresinol-DH)-like, classical (c) SDRs; Region: secoisolariciresinol-DH_like_SDR_c; cd05326 101510001045 NAD binding site [chemical binding]; other site 101510001046 homodimer interface [polypeptide binding]; other site 101510001047 substrate binding site [chemical binding]; other site 101510001048 active site 101510001049 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510001050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001051 putative substrate translocation pore; other site 101510001052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510001053 glucose-1-dehydrogenase; Provisional; Region: PRK08340 101510001054 NAD(P) binding site [chemical binding]; other site 101510001055 active site 101510001056 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 101510001057 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510001058 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510001059 acyl-activating enzyme (AAE) consensus motif; other site 101510001060 acyl-activating enzyme (AAE) consensus motif; other site 101510001061 putative AMP binding site [chemical binding]; other site 101510001062 putative active site [active] 101510001063 putative CoA binding site [chemical binding]; other site 101510001064 ferredoxin-NADP+ reductase; Region: PLN02852 101510001065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510001066 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 101510001067 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510001068 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510001069 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510001070 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 101510001071 [2Fe-2S] cluster binding site [ion binding]; other site 101510001072 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 101510001073 putative alpha subunit interface [polypeptide binding]; other site 101510001074 putative active site [active] 101510001075 putative substrate binding site [chemical binding]; other site 101510001076 Fe binding site [ion binding]; other site 101510001077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510001078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510001079 active site 101510001080 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 101510001081 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 101510001082 molybdopterin cofactor binding site; other site 101510001083 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 101510001084 molybdopterin cofactor binding site; other site 101510001085 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 101510001086 4Fe-4S binding domain; Region: Fer4; pfam00037 101510001087 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 101510001088 ferredoxin-NADP+ reductase; Region: PLN02852 101510001089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510001090 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 101510001091 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 101510001092 molybdopterin cofactor binding site; other site 101510001093 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 101510001094 molybdopterin cofactor binding site; other site 101510001095 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 101510001096 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 101510001097 molybdopterin cofactor binding site; other site 101510001098 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 101510001099 molybdopterin cofactor binding site; other site 101510001100 benzoate transport; Region: 2A0115; TIGR00895 101510001101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001102 putative substrate translocation pore; other site 101510001103 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510001104 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510001105 acyl-activating enzyme (AAE) consensus motif; other site 101510001106 putative AMP binding site [chemical binding]; other site 101510001107 putative active site [active] 101510001108 putative CoA binding site [chemical binding]; other site 101510001109 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510001110 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510001111 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510001112 CoenzymeA binding site [chemical binding]; other site 101510001113 subunit interaction site [polypeptide binding]; other site 101510001114 PHB binding site; other site 101510001115 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510001116 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510001117 substrate binding site [chemical binding]; other site 101510001118 oxyanion hole (OAH) forming residues; other site 101510001119 trimer interface [polypeptide binding]; other site 101510001120 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510001121 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 101510001122 [2Fe-2S] cluster binding site [ion binding]; other site 101510001123 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 101510001124 putative alpha subunit interface [polypeptide binding]; other site 101510001125 putative active site [active] 101510001126 putative substrate binding site [chemical binding]; other site 101510001127 Fe binding site [ion binding]; other site 101510001128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510001129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510001130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510001131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510001132 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510001133 Cytochrome P450; Region: p450; cl12078 101510001134 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 101510001135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510001136 classical (c) SDRs; Region: SDR_c; cd05233 101510001137 NAD(P) binding site [chemical binding]; other site 101510001138 ferredoxin-NADP+ reductase; Region: PLN02852 101510001139 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 101510001140 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 101510001141 AsnC family; Region: AsnC_trans_reg; pfam01037 101510001142 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510001143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001144 putative substrate translocation pore; other site 101510001145 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510001146 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 101510001147 amidohydrolase; Region: amidohydrolases; TIGR01891 101510001148 putative metal binding site [ion binding]; other site 101510001149 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 101510001150 amidohydrolase; Region: amidohydrolases; TIGR01891 101510001151 metal binding site [ion binding]; metal-binding site 101510001152 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510001153 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510001154 acyl-activating enzyme (AAE) consensus motif; other site 101510001155 AMP binding site [chemical binding]; other site 101510001156 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510001157 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510001158 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 101510001159 putative NAD(P) binding site [chemical binding]; other site 101510001160 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510001161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510001162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510001163 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 101510001164 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 101510001165 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 101510001166 tetramer interface [polypeptide binding]; other site 101510001167 heme binding pocket [chemical binding]; other site 101510001168 NADPH binding site [chemical binding]; other site 101510001169 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510001170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510001171 AAA domain; Region: AAA_22; pfam13401 101510001172 Walker A motif; other site 101510001173 ATP binding site [chemical binding]; other site 101510001174 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 101510001175 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 101510001176 dimerization interface [polypeptide binding]; other site 101510001177 putative path to active site cavity [active] 101510001178 diiron center [ion binding]; other site 101510001179 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 101510001180 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510001181 catalytic loop [active] 101510001182 iron binding site [ion binding]; other site 101510001183 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 101510001184 FAD binding pocket [chemical binding]; other site 101510001185 FAD binding motif [chemical binding]; other site 101510001186 phosphate binding motif [ion binding]; other site 101510001187 beta-alpha-beta structure motif; other site 101510001188 NAD binding pocket [chemical binding]; other site 101510001189 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 101510001190 dimerization interface [polypeptide binding]; other site 101510001191 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 101510001192 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 101510001193 active site 101510001194 Domain of unknown function DUF59; Region: DUF59; pfam01883 101510001195 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510001196 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 101510001197 NAD binding site [chemical binding]; other site 101510001198 substrate binding site [chemical binding]; other site 101510001199 catalytic Zn binding site [ion binding]; other site 101510001200 structural Zn binding site [ion binding]; other site 101510001201 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 101510001202 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 101510001203 ring oligomerisation interface [polypeptide binding]; other site 101510001204 ATP/Mg binding site [chemical binding]; other site 101510001205 stacking interactions; other site 101510001206 hinge regions; other site 101510001207 Uncharacterized conserved protein [Function unknown]; Region: COG1359 101510001208 FAD binding domain; Region: FAD_binding_4; pfam01565 101510001209 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 101510001210 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510001211 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 101510001212 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 101510001213 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 101510001214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510001215 NAD(P) binding site [chemical binding]; other site 101510001216 active site 101510001217 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 101510001218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510001219 S-adenosylmethionine binding site [chemical binding]; other site 101510001220 YCII-related domain; Region: YCII; cl00999 101510001221 MULE transposase domain; Region: MULE; pfam10551 101510001222 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510001223 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510001224 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510001225 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 101510001226 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510001227 active site 101510001228 catalytic residues [active] 101510001229 DNA binding site [nucleotide binding] 101510001230 Int/Topo IB signature motif; other site 101510001231 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510001232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 101510001233 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 101510001234 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510001235 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510001236 FMN-binding pocket [chemical binding]; other site 101510001237 flavin binding motif; other site 101510001238 phosphate binding motif [ion binding]; other site 101510001239 beta-alpha-beta structure motif; other site 101510001240 NAD binding pocket [chemical binding]; other site 101510001241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510001242 catalytic loop [active] 101510001243 iron binding site [ion binding]; other site 101510001244 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 101510001245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 101510001246 MOSC domain; Region: MOSC; pfam03473 101510001247 3-alpha domain; Region: 3-alpha; pfam03475 101510001248 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 101510001249 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 101510001250 FAD binding pocket [chemical binding]; other site 101510001251 FAD binding motif [chemical binding]; other site 101510001252 phosphate binding motif [ion binding]; other site 101510001253 beta-alpha-beta structure motif; other site 101510001254 NAD binding pocket [chemical binding]; other site 101510001255 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510001256 catalytic loop [active] 101510001257 iron binding site [ion binding]; other site 101510001258 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 101510001259 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 101510001260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510001261 Zn binding site [ion binding]; other site 101510001262 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 101510001263 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 101510001264 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 101510001265 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 101510001266 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 101510001267 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 101510001268 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 101510001269 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 101510001270 acyl-activating enzyme (AAE) consensus motif; other site 101510001271 active site 101510001272 AMP binding site [chemical binding]; other site 101510001273 substrate binding site [chemical binding]; other site 101510001274 FAD binding domain; Region: FAD_binding_3; pfam01494 101510001275 hypothetical protein; Provisional; Region: PRK07236 101510001276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510001277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510001278 Domain of unknown function (DUF385); Region: DUF385; pfam04075 101510001279 ChaB; Region: ChaB; cl01887 101510001280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510001281 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 101510001282 ATP binding site [chemical binding]; other site 101510001283 G-X-G motif; other site 101510001284 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510001285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510001286 DNA binding residues [nucleotide binding] 101510001287 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 101510001288 tetramer interface [polypeptide binding]; other site 101510001289 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 101510001290 active site 101510001291 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 101510001292 active site 101510001293 dimer interface [polypeptide binding]; other site 101510001294 magnesium binding site [ion binding]; other site 101510001295 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 101510001296 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 101510001297 Malic enzyme, N-terminal domain; Region: malic; pfam00390 101510001298 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 101510001299 putative NAD(P) binding site [chemical binding]; other site 101510001300 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 101510001301 Pleckstrin homology-like domain; Region: PH-like; cl17171 101510001302 Protein of unknown function (DUF732); Region: DUF732; pfam05305 101510001303 Integrase core domain; Region: rve; pfam00665 101510001304 Integrase core domain; Region: rve_3; pfam13683 101510001305 Transposase; Region: HTH_Tnp_1; cl17663 101510001306 LCCL domain; Region: LCCL; pfam03815 101510001307 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510001308 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510001309 active site 101510001310 ATP binding site [chemical binding]; other site 101510001311 substrate binding site [chemical binding]; other site 101510001312 activation loop (A-loop); other site 101510001313 NHL repeat; Region: NHL; pfam01436 101510001314 Uncharacterized conserved protein [Function unknown]; Region: COG3391 101510001315 NHL repeat; Region: NHL; pfam01436 101510001316 NHL repeat; Region: NHL; pfam01436 101510001317 NHL repeat; Region: NHL; pfam01436 101510001318 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 101510001319 Protein of unknown function (DUF732); Region: DUF732; pfam05305 101510001320 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 101510001321 DNA binding site [nucleotide binding] 101510001322 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 101510001323 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510001324 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510001325 phosphopeptide binding site; other site 101510001326 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 101510001327 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 101510001328 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 101510001329 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 101510001330 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510001331 metal binding site [ion binding]; metal-binding site 101510001332 active site 101510001333 I-site; other site 101510001334 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 101510001335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510001336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510001337 NAD(P) binding site [chemical binding]; other site 101510001338 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 101510001339 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 101510001340 active site 101510001341 catalytic residues [active] 101510001342 metal binding site [ion binding]; metal-binding site 101510001343 DmpG-like communication domain; Region: DmpG_comm; pfam07836 101510001344 acetaldehyde dehydrogenase; Validated; Region: PRK08300 101510001345 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510001346 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 101510001347 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 101510001348 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 101510001349 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 101510001350 putative active site [active] 101510001351 Fe(II) binding site [ion binding]; other site 101510001352 putative dimer interface [polypeptide binding]; other site 101510001353 putative tetramer interface [polypeptide binding]; other site 101510001354 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510001355 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510001356 FAD binding domain; Region: FAD_binding_3; pfam01494 101510001357 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510001358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001359 putative substrate translocation pore; other site 101510001360 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510001361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510001362 DNA-binding site [nucleotide binding]; DNA binding site 101510001363 FCD domain; Region: FCD; pfam07729 101510001364 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 101510001365 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510001366 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510001367 Isochorismatase family; Region: Isochorismatase; pfam00857 101510001368 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 101510001369 catalytic triad [active] 101510001370 conserved cis-peptide bond; other site 101510001371 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510001372 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510001373 NAD(P) binding site [chemical binding]; other site 101510001374 Transcription factor WhiB; Region: Whib; pfam02467 101510001375 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 101510001376 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 101510001377 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510001378 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 101510001379 putative FMN binding site [chemical binding]; other site 101510001380 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510001381 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510001382 active site 101510001383 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 101510001384 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 101510001385 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510001386 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 101510001387 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510001388 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 101510001389 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510001390 putative active site [active] 101510001391 putative metal binding site [ion binding]; other site 101510001392 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510001393 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510001394 FAD binding domain; Region: FAD_binding_3; pfam01494 101510001395 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510001396 hypothetical protein; Provisional; Region: PRK07236 101510001397 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 101510001398 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510001399 acyl-activating enzyme (AAE) consensus motif; other site 101510001400 AMP binding site [chemical binding]; other site 101510001401 active site 101510001402 CoA binding site [chemical binding]; other site 101510001403 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510001404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510001405 DNA-binding site [nucleotide binding]; DNA binding site 101510001406 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 101510001407 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510001408 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 101510001409 AsnC family; Region: AsnC_trans_reg; pfam01037 101510001410 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 101510001411 TPP-binding site [chemical binding]; other site 101510001412 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 101510001413 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510001414 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 101510001415 E3 interaction surface; other site 101510001416 lipoyl attachment site [posttranslational modification]; other site 101510001417 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 101510001418 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 101510001419 Transcription factor WhiB; Region: Whib; pfam02467 101510001420 Epoxide hydrolase N terminus; Region: EHN; pfam06441 101510001421 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510001422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510001423 active site 101510001424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510001425 catalytic core [active] 101510001426 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510001427 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 101510001428 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 101510001429 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 101510001430 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510001431 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 101510001432 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510001433 Cupin domain; Region: Cupin_2; cl17218 101510001434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510001435 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510001436 salt bridge; other site 101510001437 non-specific DNA binding site [nucleotide binding]; other site 101510001438 sequence-specific DNA binding site [nucleotide binding]; other site 101510001439 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 101510001440 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 101510001441 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510001442 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 101510001443 dimer interface [polypeptide binding]; other site 101510001444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510001446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510001448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510001449 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 101510001450 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510001451 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510001452 active site 101510001453 catalytic tetrad [active] 101510001454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001455 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510001456 putative substrate translocation pore; other site 101510001457 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 101510001458 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510001459 catalytic Zn binding site [ion binding]; other site 101510001460 NAD(P) binding site [chemical binding]; other site 101510001461 structural Zn binding site [ion binding]; other site 101510001462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510001463 salt bridge; other site 101510001464 non-specific DNA binding site [nucleotide binding]; other site 101510001465 sequence-specific DNA binding site [nucleotide binding]; other site 101510001466 hypothetical protein; Provisional; Region: PRK11171 101510001467 Cupin domain; Region: Cupin_2; pfam07883 101510001468 Cupin domain; Region: Cupin_2; pfam07883 101510001469 LexA repressor; Validated; Region: PRK00215 101510001470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510001471 putative DNA binding site [nucleotide binding]; other site 101510001472 putative Zn2+ binding site [ion binding]; other site 101510001473 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 101510001474 Catalytic site [active] 101510001475 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 101510001476 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 101510001477 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 101510001478 NAD(P) binding site [chemical binding]; other site 101510001479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510001480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510001481 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 101510001482 putative dimerization interface [polypeptide binding]; other site 101510001483 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510001484 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 101510001485 Syd protein (SUKH-2); Region: Syd; cl06405 101510001486 Uncharacterized conserved protein [Function unknown]; Region: COG0397 101510001487 hypothetical protein; Validated; Region: PRK00029 101510001488 YCII-related domain; Region: YCII; cl00999 101510001489 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 101510001490 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 101510001491 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510001492 putative NAD(P) binding site [chemical binding]; other site 101510001493 DoxX-like family; Region: DoxX_2; pfam13564 101510001494 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510001495 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510001496 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510001497 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510001498 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 101510001499 active site 2 [active] 101510001500 active site 1 [active] 101510001501 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510001502 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 101510001503 NAD(P) binding site [chemical binding]; other site 101510001504 catalytic residues [active] 101510001505 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 101510001506 DNA-binding site [nucleotide binding]; DNA binding site 101510001507 RNA-binding motif; other site 101510001508 Methyltransferase domain; Region: Methyltransf_23; pfam13489 101510001509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 101510001510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510001511 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510001512 active site 101510001513 catalytic tetrad [active] 101510001514 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 101510001515 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 101510001516 active site 101510001517 dimer interface [polypeptide binding]; other site 101510001518 non-prolyl cis peptide bond; other site 101510001519 insertion regions; other site 101510001520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510001521 Coenzyme A binding pocket [chemical binding]; other site 101510001522 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 101510001523 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 101510001524 dimer interface [polypeptide binding]; other site 101510001525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510001526 catalytic residue [active] 101510001527 Transcription factor WhiB; Region: Whib; pfam02467 101510001528 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510001529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510001530 DNA-binding site [nucleotide binding]; DNA binding site 101510001531 FCD domain; Region: FCD; pfam07729 101510001532 cytosine deaminase; Provisional; Region: PRK05985 101510001533 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 101510001534 active site 101510001535 Amino acid permease; Region: AA_permease; pfam00324 101510001536 cytosine deaminase; Provisional; Region: PRK05985 101510001537 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 101510001538 active site 101510001539 Putative zinc-finger; Region: zf-HC2; pfam13490 101510001540 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 101510001541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510001542 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510001543 DNA binding residues [nucleotide binding] 101510001544 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 101510001545 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 101510001546 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 101510001547 putative heme binding pocket [chemical binding]; other site 101510001548 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 101510001549 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 101510001550 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 101510001551 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 101510001552 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 101510001553 YCII-related domain; Region: YCII; cl00999 101510001554 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 101510001555 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510001556 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 101510001557 dimer interface [polypeptide binding]; other site 101510001558 active site 101510001559 catalytic residue [active] 101510001560 Clp protease ATP binding subunit; Region: clpC; CHL00095 101510001561 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 101510001562 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 101510001563 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510001564 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 101510001565 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510001566 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 101510001567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510001568 non-specific DNA binding site [nucleotide binding]; other site 101510001569 salt bridge; other site 101510001570 sequence-specific DNA binding site [nucleotide binding]; other site 101510001571 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510001572 Cutinase; Region: Cutinase; pfam01083 101510001573 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 101510001574 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510001575 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 101510001576 NADP binding site [chemical binding]; other site 101510001577 dimer interface [polypeptide binding]; other site 101510001578 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510001579 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510001580 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510001581 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510001582 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510001583 active site 101510001584 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510001585 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 101510001586 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 101510001587 protein binding site [polypeptide binding]; other site 101510001588 Ion channel; Region: Ion_trans_2; pfam07885 101510001589 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 101510001590 TrkA-N domain; Region: TrkA_N; pfam02254 101510001591 TrkA-C domain; Region: TrkA_C; pfam02080 101510001592 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 101510001593 YCII-related domain; Region: YCII; cl00999 101510001594 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 101510001595 iron-sulfur cluster [ion binding]; other site 101510001596 [2Fe-2S] cluster binding site [ion binding]; other site 101510001597 HicB family; Region: HicB; pfam05534 101510001598 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 101510001599 Uncharacterized conserved protein [Function unknown]; Region: COG1359 101510001600 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 101510001601 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 101510001602 NAD(P) binding site [chemical binding]; other site 101510001603 catalytic residues [active] 101510001604 Cupin domain; Region: Cupin_2; pfam07883 101510001605 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 101510001606 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 101510001607 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510001608 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510001609 Ligand Binding Site [chemical binding]; other site 101510001610 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 101510001611 Citrate transporter; Region: CitMHS; pfam03600 101510001612 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510001613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510001614 DNA-binding site [nucleotide binding]; DNA binding site 101510001615 FCD domain; Region: FCD; pfam07729 101510001616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 101510001617 Helix-turn-helix domain; Region: HTH_38; pfam13936 101510001618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510001619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510001620 Walker A motif; other site 101510001621 ATP binding site [chemical binding]; other site 101510001622 Walker B motif; other site 101510001623 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510001624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 101510001625 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 101510001626 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 101510001627 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510001628 active site 101510001629 catalytic residues [active] 101510001630 DNA binding site [nucleotide binding] 101510001631 Int/Topo IB signature motif; other site 101510001632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510001633 putative transposase OrfB; Reviewed; Region: PHA02517 101510001634 HTH-like domain; Region: HTH_21; pfam13276 101510001635 Integrase core domain; Region: rve; pfam00665 101510001636 Integrase core domain; Region: rve_3; pfam13683 101510001637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 101510001638 Transposase; Region: HTH_Tnp_1; cl17663 101510001639 PAS fold; Region: PAS_3; pfam08447 101510001640 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510001641 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 101510001642 Gas vesicle protein; Region: Gas_vesicle; cl02954 101510001643 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 101510001644 putative hydrophobic ligand binding site [chemical binding]; other site 101510001645 PAS domain; Region: PAS_9; pfam13426 101510001646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 101510001647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510001648 metal binding site [ion binding]; metal-binding site 101510001649 active site 101510001650 I-site; other site 101510001651 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 101510001652 Gas vesicle protein; Region: Gas_vesicle; cl02954 101510001653 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510001654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510001655 active site 101510001656 ATP binding site [chemical binding]; other site 101510001657 substrate binding site [chemical binding]; other site 101510001658 activation loop (A-loop); other site 101510001659 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 101510001660 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510001661 hydrophobic ligand binding site; other site 101510001662 CHAD domain; Region: CHAD; cl10506 101510001663 Gas vesicle protein; Region: Gas_vesicle; cl02954 101510001664 PAS domain; Region: PAS_9; pfam13426 101510001665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 101510001666 putative active site [active] 101510001667 heme pocket [chemical binding]; other site 101510001668 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 101510001669 putative hydrophobic ligand binding site [chemical binding]; other site 101510001670 Gas vesicle protein; Region: Gas_vesicle; cl02954 101510001671 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 101510001672 Gas vesicle protein G; Region: GvpG; pfam05120 101510001673 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 101510001674 Gas vesicle protein; Region: Gas_vesicle; pfam00741 101510001675 Gas vesicle protein; Region: Gas_vesicle; cl02954 101510001676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510001677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510001678 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 101510001679 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 101510001680 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 101510001681 dimer interface [polypeptide binding]; other site 101510001682 PYR/PP interface [polypeptide binding]; other site 101510001683 TPP binding site [chemical binding]; other site 101510001684 substrate binding site [chemical binding]; other site 101510001685 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 101510001686 TPP-binding site; other site 101510001687 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 101510001688 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 101510001689 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 101510001690 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 101510001691 substrate binding site [chemical binding]; other site 101510001692 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 101510001693 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 101510001694 substrate binding site [chemical binding]; other site 101510001695 ligand binding site [chemical binding]; other site 101510001696 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510001697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510001698 putative DNA binding site [nucleotide binding]; other site 101510001699 putative Zn2+ binding site [ion binding]; other site 101510001700 AsnC family; Region: AsnC_trans_reg; pfam01037 101510001701 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 101510001702 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 101510001703 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510001704 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 101510001705 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 101510001706 putative di-iron ligands [ion binding]; other site 101510001707 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 101510001708 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 101510001709 FAD binding pocket [chemical binding]; other site 101510001710 FAD binding motif [chemical binding]; other site 101510001711 phosphate binding motif [ion binding]; other site 101510001712 beta-alpha-beta structure motif; other site 101510001713 NAD(p) ribose binding residues [chemical binding]; other site 101510001714 NAD binding pocket [chemical binding]; other site 101510001715 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 101510001716 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510001717 catalytic loop [active] 101510001718 iron binding site [ion binding]; other site 101510001719 Histone methylation protein DOT1; Region: DOT1; pfam08123 101510001720 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510001721 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510001722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510001723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510001724 DNA binding residues [nucleotide binding] 101510001725 dimerization interface [polypeptide binding]; other site 101510001726 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 101510001727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510001728 S-adenosylmethionine binding site [chemical binding]; other site 101510001729 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510001730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510001731 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510001732 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 101510001733 catalytic residues [active] 101510001734 catalytic nucleophile [active] 101510001735 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 101510001736 putative dimer interface [polypeptide binding]; other site 101510001737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510001738 Integrase core domain; Region: rve_3; cl15866 101510001739 HTH-like domain; Region: HTH_21; pfam13276 101510001740 Integrase core domain; Region: rve; pfam00665 101510001741 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510001742 hydrophobic ligand binding site; other site 101510001743 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 101510001744 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 101510001745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 101510001746 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 101510001747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510001748 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510001749 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510001750 Domain of unknown function (DUF385); Region: DUF385; cl04387 101510001751 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 101510001752 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 101510001753 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 101510001754 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510001755 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510001756 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510001757 active site 101510001758 ATP binding site [chemical binding]; other site 101510001759 substrate binding site [chemical binding]; other site 101510001760 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510001761 substrate binding site [chemical binding]; other site 101510001762 activation loop (A-loop); other site 101510001763 activation loop (A-loop); other site 101510001764 AAA ATPase domain; Region: AAA_16; pfam13191 101510001765 Predicted ATPase [General function prediction only]; Region: COG3903 101510001766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 101510001767 TPR motif; other site 101510001768 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510001769 binding surface 101510001770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510001771 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510001772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510001773 DNA binding residues [nucleotide binding] 101510001774 dimerization interface [polypeptide binding]; other site 101510001775 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510001776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510001777 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510001778 active site 101510001779 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 101510001780 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510001781 active site 2 [active] 101510001782 active site 1 [active] 101510001783 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510001784 active site 2 [active] 101510001785 active site 1 [active] 101510001786 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510001787 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510001788 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 101510001789 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510001790 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510001791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510001792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510001793 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 101510001794 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 101510001795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510001796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510001797 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 101510001798 putative dimerization interface [polypeptide binding]; other site 101510001799 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 101510001800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 101510001801 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 101510001802 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510001803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510001804 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 101510001805 putative dimerization interface [polypeptide binding]; other site 101510001806 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510001807 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510001808 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 101510001809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510001810 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510001811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510001812 Cupin domain; Region: Cupin_2; pfam07883 101510001813 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510001814 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 101510001815 putative NAD(P) binding site [chemical binding]; other site 101510001816 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510001817 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510001818 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 101510001819 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 101510001820 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 101510001821 CGNR zinc finger; Region: zf-CGNR; pfam11706 101510001822 Predicted ATPase [General function prediction only]; Region: COG3903 101510001823 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510001824 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510001825 DNA binding residues [nucleotide binding] 101510001826 dimerization interface [polypeptide binding]; other site 101510001827 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 101510001828 RibD C-terminal domain; Region: RibD_C; cl17279 101510001829 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510001830 TIGR03086 family protein; Region: TIGR03086 101510001831 benzoate transport; Region: 2A0115; TIGR00895 101510001832 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 101510001833 dimer interface [polypeptide binding]; other site 101510001834 FMN binding site [chemical binding]; other site 101510001835 NADPH bind site [chemical binding]; other site 101510001836 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 101510001837 classical (c) SDRs; Region: SDR_c; cd05233 101510001838 NAD(P) binding site [chemical binding]; other site 101510001839 active site 101510001840 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 101510001841 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 101510001842 putative active site [active] 101510001843 putative NTP binding site [chemical binding]; other site 101510001844 putative nucleic acid binding site [nucleotide binding]; other site 101510001845 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 101510001846 homotrimer interaction site [polypeptide binding]; other site 101510001847 putative active site [active] 101510001848 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510001849 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510001850 Walker A/P-loop; other site 101510001851 ATP binding site [chemical binding]; other site 101510001852 Q-loop/lid; other site 101510001853 ABC transporter signature motif; other site 101510001854 Walker B; other site 101510001855 D-loop; other site 101510001856 H-loop/switch region; other site 101510001857 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 101510001858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510001859 dimer interface [polypeptide binding]; other site 101510001860 conserved gate region; other site 101510001861 putative PBP binding loops; other site 101510001862 ABC-ATPase subunit interface; other site 101510001863 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 101510001864 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510001865 phosphate binding site [ion binding]; other site 101510001866 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510001867 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 101510001868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510001869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510001870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510001871 dimerization interface [polypeptide binding]; other site 101510001872 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510001873 Nitronate monooxygenase; Region: NMO; pfam03060 101510001874 FMN binding site [chemical binding]; other site 101510001875 substrate binding site [chemical binding]; other site 101510001876 putative catalytic residue [active] 101510001877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510001878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510001879 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 101510001880 dimerization interface [polypeptide binding]; other site 101510001881 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 101510001882 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cd12193 101510001883 DNA binding site [nucleotide binding] 101510001884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001885 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510001886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510001887 putative substrate translocation pore; other site 101510001888 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 101510001889 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510001890 FMN binding site [chemical binding]; other site 101510001891 substrate binding site [chemical binding]; other site 101510001892 putative catalytic residue [active] 101510001893 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 101510001894 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 101510001895 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 101510001896 PYR/PP interface [polypeptide binding]; other site 101510001897 dimer interface [polypeptide binding]; other site 101510001898 TPP binding site [chemical binding]; other site 101510001899 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510001900 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 101510001901 TPP-binding site [chemical binding]; other site 101510001902 dimer interface [polypeptide binding]; other site 101510001903 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510001904 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510001905 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510001906 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 101510001907 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510001908 putative ligand binding site [chemical binding]; other site 101510001909 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510001910 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510001911 Walker A/P-loop; other site 101510001912 ATP binding site [chemical binding]; other site 101510001913 Q-loop/lid; other site 101510001914 ABC transporter signature motif; other site 101510001915 Walker B; other site 101510001916 D-loop; other site 101510001917 H-loop/switch region; other site 101510001918 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510001919 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510001920 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510001921 TM-ABC transporter signature motif; other site 101510001922 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510001923 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 101510001924 tetramerization interface [polypeptide binding]; other site 101510001925 NAD(P) binding site [chemical binding]; other site 101510001926 catalytic residues [active] 101510001927 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 101510001928 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 101510001929 NAD(P) binding site [chemical binding]; other site 101510001930 active site 101510001931 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510001932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510001933 Cupin domain; Region: Cupin_2; pfam07883 101510001934 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 101510001935 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 101510001936 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 101510001937 active site 101510001938 SAM binding site [chemical binding]; other site 101510001939 homodimer interface [polypeptide binding]; other site 101510001940 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 101510001941 active site 101510001942 putative homodimer interface [polypeptide binding]; other site 101510001943 SAM binding site [chemical binding]; other site 101510001944 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 101510001945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510001946 S-adenosylmethionine binding site [chemical binding]; other site 101510001947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510001948 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 101510001949 NAD(P) binding site [chemical binding]; other site 101510001950 active site 101510001951 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 101510001952 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 101510001953 Ligand binding site; other site 101510001954 Putative Catalytic site; other site 101510001955 DXD motif; other site 101510001956 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 101510001957 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 101510001958 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 101510001959 active site 101510001960 5'-3' exonuclease (including N-terminal domain of PolI) [DNA replication, recombination, and repair]; Region: Exo; COG0258 101510001961 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 101510001962 active site 101510001963 metal binding site 1 [ion binding]; metal-binding site 101510001964 putative 5' ssDNA interaction site; other site 101510001965 metal binding site 3; metal-binding site 101510001966 metal binding site 2 [ion binding]; metal-binding site 101510001967 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 101510001968 putative DNA binding site [nucleotide binding]; other site 101510001969 putative metal binding site [ion binding]; other site 101510001970 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 101510001971 DEAD-like helicases superfamily; Region: DEXDc; smart00487 101510001972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510001973 ATP binding site [chemical binding]; other site 101510001974 putative Mg++ binding site [ion binding]; other site 101510001975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510001976 nucleotide binding region [chemical binding]; other site 101510001977 ATP-binding site [chemical binding]; other site 101510001978 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 101510001979 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 101510001980 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 101510001981 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 101510001982 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 101510001983 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 101510001984 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 101510001985 Predicted transcriptional regulator [Transcription]; Region: COG2378 101510001986 WYL domain; Region: WYL; pfam13280 101510001987 Predicted transcriptional regulator [Transcription]; Region: COG2378 101510001988 WYL domain; Region: WYL; pfam13280 101510001989 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 101510001990 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 101510001991 active site 101510001992 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 101510001993 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 101510001994 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 101510001995 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 101510001996 active site 101510001997 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 101510001998 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 101510001999 active site 101510002000 Pup-like protein; Region: Pup; cl05289 101510002001 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 101510002002 Domain of unknown function (DUF385); Region: DUF385; cl04387 101510002003 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 101510002004 nudix motif; other site 101510002005 proteasome ATPase; Region: pup_AAA; TIGR03689 101510002006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510002007 Walker A motif; other site 101510002008 ATP binding site [chemical binding]; other site 101510002009 Walker B motif; other site 101510002010 arginine finger; other site 101510002011 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 101510002012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510002013 S-adenosylmethionine binding site [chemical binding]; other site 101510002014 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 101510002015 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 101510002016 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510002017 active site 2 [active] 101510002018 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 101510002019 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 101510002020 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 101510002021 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 101510002022 homodimer interface [polypeptide binding]; other site 101510002023 putative metal binding site [ion binding]; other site 101510002024 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 101510002025 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 101510002026 probable active site [active] 101510002027 hypothetical protein; Validated; Region: PRK01415 101510002028 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 101510002029 active site residue [active] 101510002030 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 101510002031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510002032 motif II; other site 101510002033 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 101510002034 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 101510002035 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 101510002036 substrate binding pocket [chemical binding]; other site 101510002037 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 101510002038 B12 binding site [chemical binding]; other site 101510002039 cobalt ligand [ion binding]; other site 101510002040 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 101510002041 PAC2 family; Region: PAC2; pfam09754 101510002042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510002043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510002044 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 101510002045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510002046 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 101510002047 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 101510002048 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510002049 iron-sulfur cluster [ion binding]; other site 101510002050 [2Fe-2S] cluster binding site [ion binding]; other site 101510002051 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 101510002052 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510002053 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 101510002054 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510002055 hypothetical protein; Provisional; Region: PRK07758 101510002056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510002057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510002058 non-specific DNA binding site [nucleotide binding]; other site 101510002059 salt bridge; other site 101510002060 sequence-specific DNA binding site [nucleotide binding]; other site 101510002061 Cupin domain; Region: Cupin_2; pfam07883 101510002062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510002063 S-adenosylmethionine binding site [chemical binding]; other site 101510002064 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 101510002065 TIGR02677 family protein; Region: TIGR02677 101510002066 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 101510002067 TIGR02680 family protein; Region: TIGR02680 101510002068 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 101510002069 Transposase domain (DUF772); Region: DUF772; pfam05598 101510002070 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510002071 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510002072 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 101510002073 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 101510002074 active site 101510002075 HIGH motif; other site 101510002076 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 101510002077 active site 101510002078 KMSKS motif; other site 101510002079 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 101510002080 putative tRNA binding surface [nucleotide binding]; other site 101510002081 conserved hypothetical protein; Region: TIGR03843 101510002082 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 101510002083 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510002084 catalytic core [active] 101510002085 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 101510002086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510002087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510002088 active site 101510002089 catalytic tetrad [active] 101510002090 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 101510002091 heme binding pocket [chemical binding]; other site 101510002092 heme ligand [chemical binding]; other site 101510002093 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 101510002094 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 101510002095 intersubunit interface [polypeptide binding]; other site 101510002096 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 101510002097 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 101510002098 dimer interface [polypeptide binding]; other site 101510002099 putative PBP binding regions; other site 101510002100 ABC-ATPase subunit interface; other site 101510002101 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 101510002102 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 101510002103 Walker A/P-loop; other site 101510002104 ATP binding site [chemical binding]; other site 101510002105 Q-loop/lid; other site 101510002106 ABC transporter signature motif; other site 101510002107 Walker B; other site 101510002108 D-loop; other site 101510002109 H-loop/switch region; other site 101510002110 Glycyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: GRS1; COG0423 101510002111 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 101510002112 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 101510002113 quinone interaction residues [chemical binding]; other site 101510002114 active site 101510002115 catalytic residues [active] 101510002116 FMN binding site [chemical binding]; other site 101510002117 substrate binding site [chemical binding]; other site 101510002118 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 101510002119 substrate binding site [chemical binding]; other site 101510002120 hypothetical protein; Provisional; Region: PRK07906 101510002121 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 101510002122 putative metal binding site [ion binding]; other site 101510002123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510002124 NAD(P) binding site [chemical binding]; other site 101510002125 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 101510002126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510002127 active site 101510002128 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510002129 Ligand Binding Site [chemical binding]; other site 101510002130 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 101510002131 Uncharacterized conserved protein [Function unknown]; Region: COG3268 101510002132 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510002133 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 101510002134 active site 101510002135 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 101510002136 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 101510002137 metal ion-dependent adhesion site (MIDAS); other site 101510002138 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 101510002139 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 101510002140 putative active site [active] 101510002141 putative metal binding site [ion binding]; other site 101510002142 glycine dehydrogenase; Provisional; Region: PRK05367 101510002143 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 101510002144 tetramer interface [polypeptide binding]; other site 101510002145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510002146 catalytic residue [active] 101510002147 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 101510002148 tetramer interface [polypeptide binding]; other site 101510002149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510002150 catalytic residue [active] 101510002151 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 101510002152 DNA binding residues [nucleotide binding] 101510002153 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510002154 putative dimer interface [polypeptide binding]; other site 101510002155 Bifunctional nuclease; Region: DNase-RNase; pfam02577 101510002156 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 101510002157 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510002158 DNA binding residues [nucleotide binding] 101510002159 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510002160 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510002161 phosphopeptide binding site; other site 101510002162 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 101510002163 lipoyl attachment site [posttranslational modification]; other site 101510002164 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 101510002165 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 101510002166 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 101510002167 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 101510002168 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 101510002169 Strictosidine synthase; Region: Str_synth; pfam03088 101510002170 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 101510002171 putative active site [active] 101510002172 putative CoA binding site [chemical binding]; other site 101510002173 nudix motif; other site 101510002174 metal binding site [ion binding]; metal-binding site 101510002175 acyl-CoA synthetase; Validated; Region: PRK06188 101510002176 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510002177 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510002178 acyl-activating enzyme (AAE) consensus motif; other site 101510002179 acyl-activating enzyme (AAE) consensus motif; other site 101510002180 putative AMP binding site [chemical binding]; other site 101510002181 putative active site [active] 101510002182 putative CoA binding site [chemical binding]; other site 101510002183 Uncharacterized conserved protein [Function unknown]; Region: COG3268 101510002184 classical (c) SDRs; Region: SDR_c; cd05233 101510002185 NAD(P) binding site [chemical binding]; other site 101510002186 active site 101510002187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510002188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510002189 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 101510002190 putative hydrophobic ligand binding site [chemical binding]; other site 101510002191 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510002192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510002193 putative substrate translocation pore; other site 101510002194 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 101510002195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510002196 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 101510002197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 101510002198 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 101510002199 GTP-binding protein Der; Reviewed; Region: PRK03003 101510002200 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 101510002201 G1 box; other site 101510002202 GTP/Mg2+ binding site [chemical binding]; other site 101510002203 Switch I region; other site 101510002204 G2 box; other site 101510002205 Switch II region; other site 101510002206 G3 box; other site 101510002207 G4 box; other site 101510002208 G5 box; other site 101510002209 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 101510002210 G1 box; other site 101510002211 GTP/Mg2+ binding site [chemical binding]; other site 101510002212 Switch I region; other site 101510002213 G2 box; other site 101510002214 G3 box; other site 101510002215 Switch II region; other site 101510002216 G4 box; other site 101510002217 G5 box; other site 101510002218 cytidylate kinase; Provisional; Region: cmk; PRK00023 101510002219 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 101510002220 CMP-binding site; other site 101510002221 The sites determining sugar specificity; other site 101510002222 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 101510002223 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 101510002224 RNA binding surface [nucleotide binding]; other site 101510002225 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 101510002226 active site 101510002227 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 101510002228 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 101510002229 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510002230 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510002231 P-loop; other site 101510002232 Magnesium ion binding site [ion binding]; other site 101510002233 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510002234 Magnesium ion binding site [ion binding]; other site 101510002235 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 101510002236 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510002237 active site 101510002238 DNA binding site [nucleotide binding] 101510002239 Int/Topo IB signature motif; other site 101510002240 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 101510002241 dimer interface [polypeptide binding]; other site 101510002242 active site 101510002243 ADP-ribose binding site [chemical binding]; other site 101510002244 nudix motif; other site 101510002245 metal binding site [ion binding]; metal-binding site 101510002246 CTP synthetase; Validated; Region: pyrG; PRK05380 101510002247 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 101510002248 Catalytic site [active] 101510002249 active site 101510002250 UTP binding site [chemical binding]; other site 101510002251 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 101510002252 active site 101510002253 putative oxyanion hole; other site 101510002254 catalytic triad [active] 101510002255 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 101510002256 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 101510002257 Thiamine pyrophosphokinase; Region: TPK; cl08415 101510002258 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 101510002259 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 101510002260 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 101510002261 Walker A/P-loop; other site 101510002262 ATP binding site [chemical binding]; other site 101510002263 Q-loop/lid; other site 101510002264 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 101510002265 ABC transporter signature motif; other site 101510002266 Walker B; other site 101510002267 D-loop; other site 101510002268 H-loop/switch region; other site 101510002269 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 101510002270 ATP-NAD kinase; Region: NAD_kinase; pfam01513 101510002271 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 101510002272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510002273 S-adenosylmethionine binding site [chemical binding]; other site 101510002274 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 101510002275 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 101510002276 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 101510002277 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 101510002278 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 101510002279 active site 101510002280 HIGH motif; other site 101510002281 dimer interface [polypeptide binding]; other site 101510002282 KMSKS motif; other site 101510002283 S4 RNA-binding domain; Region: S4; smart00363 101510002284 RNA binding surface [nucleotide binding]; other site 101510002285 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 101510002286 active site 101510002287 DNA binding site [nucleotide binding] 101510002288 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 101510002289 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 101510002290 Walker A/P-loop; other site 101510002291 ATP binding site [chemical binding]; other site 101510002292 Q-loop/lid; other site 101510002293 ABC transporter signature motif; other site 101510002294 Walker B; other site 101510002295 D-loop; other site 101510002296 H-loop/switch region; other site 101510002297 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510002298 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510002299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510002300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510002301 Uncharacterized conserved protein [Function unknown]; Region: COG2835 101510002302 acyl-CoA synthetase; Validated; Region: PRK07868 101510002303 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510002304 acyl-activating enzyme (AAE) consensus motif; other site 101510002305 active site 101510002306 AMP binding site [chemical binding]; other site 101510002307 CoA binding site [chemical binding]; other site 101510002308 argininosuccinate lyase; Provisional; Region: PRK00855 101510002309 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 101510002310 active sites [active] 101510002311 tetramer interface [polypeptide binding]; other site 101510002312 argininosuccinate synthase; Provisional; Region: PRK13820 101510002313 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 101510002314 ANP binding site [chemical binding]; other site 101510002315 Substrate Binding Site II [chemical binding]; other site 101510002316 Substrate Binding Site I [chemical binding]; other site 101510002317 Arginine repressor [Transcription]; Region: ArgR; COG1438 101510002318 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 101510002319 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 101510002320 ornithine carbamoyltransferase; Provisional; Region: PRK00779 101510002321 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 101510002322 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 101510002323 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 101510002324 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510002325 inhibitor-cofactor binding pocket; inhibition site 101510002326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510002327 catalytic residue [active] 101510002328 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 101510002329 feedback inhibition sensing region; other site 101510002330 homohexameric interface [polypeptide binding]; other site 101510002331 nucleotide binding site [chemical binding]; other site 101510002332 N-acetyl-L-glutamate binding site [chemical binding]; other site 101510002333 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 101510002334 heterotetramer interface [polypeptide binding]; other site 101510002335 active site pocket [active] 101510002336 cleavage site 101510002337 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 101510002338 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510002339 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 101510002340 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 101510002341 putative tRNA-binding site [nucleotide binding]; other site 101510002342 B3/4 domain; Region: B3_4; pfam03483 101510002343 tRNA synthetase B5 domain; Region: B5; smart00874 101510002344 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 101510002345 dimer interface [polypeptide binding]; other site 101510002346 motif 1; other site 101510002347 motif 3; other site 101510002348 motif 2; other site 101510002349 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 101510002350 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 101510002351 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 101510002352 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 101510002353 dimer interface [polypeptide binding]; other site 101510002354 motif 1; other site 101510002355 active site 101510002356 motif 2; other site 101510002357 motif 3; other site 101510002358 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 101510002359 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 101510002360 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 101510002361 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 101510002362 23S rRNA binding site [nucleotide binding]; other site 101510002363 L21 binding site [polypeptide binding]; other site 101510002364 L13 binding site [polypeptide binding]; other site 101510002365 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 101510002366 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 101510002367 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 101510002368 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 101510002369 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 101510002370 HTH domain; Region: HTH_11; pfam08279 101510002371 WYL domain; Region: WYL; pfam13280 101510002372 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 101510002373 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510002374 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 101510002375 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 101510002376 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 101510002377 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 101510002378 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 101510002379 DoxX; Region: DoxX; pfam07681 101510002380 Predicted membrane protein [Function unknown]; Region: COG2259 101510002381 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 101510002382 Part of AAA domain; Region: AAA_19; pfam13245 101510002383 Family description; Region: UvrD_C_2; pfam13538 101510002384 Protein of unknown function (DUF732); Region: DUF732; pfam05305 101510002385 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510002386 Ligand Binding Site [chemical binding]; other site 101510002387 excinuclease ABC subunit B; Provisional; Region: PRK05298 101510002388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510002389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510002390 nucleotide binding region [chemical binding]; other site 101510002391 ATP-binding site [chemical binding]; other site 101510002392 Ultra-violet resistance protein B; Region: UvrB; pfam12344 101510002393 UvrB/uvrC motif; Region: UVR; pfam02151 101510002394 Protein of unknown function (DUF402); Region: DUF402; cl00979 101510002395 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 101510002396 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 101510002397 CoA-binding site [chemical binding]; other site 101510002398 ATP-binding [chemical binding]; other site 101510002399 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 101510002400 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 101510002401 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 101510002402 RNA binding site [nucleotide binding]; other site 101510002403 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 101510002404 RNA binding site [nucleotide binding]; other site 101510002405 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 101510002406 RNA binding site [nucleotide binding]; other site 101510002407 S1 RNA binding domain; Region: S1; pfam00575 101510002408 RNA binding site [nucleotide binding]; other site 101510002409 Methyltransferase domain; Region: Methyltransf_31; pfam13847 101510002410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510002411 S-adenosylmethionine binding site [chemical binding]; other site 101510002412 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510002413 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510002414 Walker A/P-loop; other site 101510002415 ATP binding site [chemical binding]; other site 101510002416 Q-loop/lid; other site 101510002417 ABC transporter signature motif; other site 101510002418 Walker B; other site 101510002419 D-loop; other site 101510002420 H-loop/switch region; other site 101510002421 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 101510002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510002423 dimer interface [polypeptide binding]; other site 101510002424 conserved gate region; other site 101510002425 putative PBP binding loops; other site 101510002426 ABC-ATPase subunit interface; other site 101510002427 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510002428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510002429 substrate binding pocket [chemical binding]; other site 101510002430 membrane-bound complex binding site; other site 101510002431 hinge residues; other site 101510002432 tartrate dehydrogenase; Provisional; Region: PRK08194 101510002433 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 101510002434 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 101510002435 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 101510002436 EamA-like transporter family; Region: EamA; pfam00892 101510002437 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 101510002438 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 101510002439 conserved cys residue [active] 101510002440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510002441 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 101510002442 catalytic residues [active] 101510002443 DNA polymerase I; Region: pola; TIGR00593 101510002444 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 101510002445 active site 101510002446 metal binding site 1 [ion binding]; metal-binding site 101510002447 putative 5' ssDNA interaction site; other site 101510002448 metal binding site 3; metal-binding site 101510002449 metal binding site 2 [ion binding]; metal-binding site 101510002450 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 101510002451 putative DNA binding site [nucleotide binding]; other site 101510002452 putative metal binding site [ion binding]; other site 101510002453 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 101510002454 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 101510002455 active site 101510002456 DNA binding site [nucleotide binding] 101510002457 catalytic site [active] 101510002458 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 101510002459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510002460 TM-ABC transporter signature motif; other site 101510002461 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 101510002462 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 101510002463 TM-ABC transporter signature motif; other site 101510002464 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 101510002465 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 101510002466 Walker A/P-loop; other site 101510002467 ATP binding site [chemical binding]; other site 101510002468 Q-loop/lid; other site 101510002469 ABC transporter signature motif; other site 101510002470 Walker B; other site 101510002471 D-loop; other site 101510002472 H-loop/switch region; other site 101510002473 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 101510002474 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 101510002475 Walker A/P-loop; other site 101510002476 ATP binding site [chemical binding]; other site 101510002477 Q-loop/lid; other site 101510002478 ABC transporter signature motif; other site 101510002479 Walker B; other site 101510002480 D-loop; other site 101510002481 H-loop/switch region; other site 101510002482 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 101510002483 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 101510002484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510002485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510002486 short chain dehydrogenase; Provisional; Region: PRK06180 101510002487 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 101510002488 NADP binding site [chemical binding]; other site 101510002489 active site 101510002490 steroid binding site; other site 101510002491 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 101510002492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510002493 active site 101510002494 phosphorylation site [posttranslational modification] 101510002495 intermolecular recognition site; other site 101510002496 dimerization interface [polypeptide binding]; other site 101510002497 ANTAR domain; Region: ANTAR; pfam03861 101510002498 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 101510002499 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510002500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510002501 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 101510002502 putative hydrophobic ligand binding site [chemical binding]; other site 101510002503 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510002504 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 101510002505 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 101510002506 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 101510002507 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 101510002508 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 101510002509 active site 101510002510 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 101510002511 catalytic triad [active] 101510002512 dimer interface [polypeptide binding]; other site 101510002513 pyruvate kinase; Provisional; Region: PRK06247 101510002514 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 101510002515 domain interfaces; other site 101510002516 active site 101510002517 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 101510002518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510002519 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 101510002520 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 101510002521 active site 101510002522 dimer interface [polypeptide binding]; other site 101510002523 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 101510002524 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 101510002525 active site 101510002526 FMN binding site [chemical binding]; other site 101510002527 substrate binding site [chemical binding]; other site 101510002528 3Fe-4S cluster binding site [ion binding]; other site 101510002529 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 101510002530 domain interface; other site 101510002531 TM2 domain; Region: TM2; pfam05154 101510002532 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 101510002533 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 101510002534 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 101510002535 substrate binding site [chemical binding]; other site 101510002536 active site 101510002537 catalytic residues [active] 101510002538 heterodimer interface [polypeptide binding]; other site 101510002539 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 101510002540 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 101510002541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510002542 catalytic residue [active] 101510002543 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 101510002544 active site 101510002545 ribulose/triose binding site [chemical binding]; other site 101510002546 phosphate binding site [ion binding]; other site 101510002547 substrate (anthranilate) binding pocket [chemical binding]; other site 101510002548 product (indole) binding pocket [chemical binding]; other site 101510002549 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 101510002550 anthranilate synthase component I; Provisional; Region: PRK13571 101510002551 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 101510002552 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 101510002553 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 101510002554 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 101510002555 catalytic triad [active] 101510002556 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 101510002557 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 101510002558 putative active site [active] 101510002559 metal binding site [ion binding]; metal-binding site 101510002560 MarR family; Region: MarR_2; cl17246 101510002561 Tautomerase enzyme; Region: Tautomerase; pfam01361 101510002562 active site 1 [active] 101510002563 dimer interface [polypeptide binding]; other site 101510002564 hexamer interface [polypeptide binding]; other site 101510002565 active site 2 [active] 101510002566 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 101510002567 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 101510002568 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 101510002569 substrate binding site [chemical binding]; other site 101510002570 glutamase interaction surface [polypeptide binding]; other site 101510002571 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 101510002572 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 101510002573 active site 101510002574 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 101510002575 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 101510002576 catalytic residues [active] 101510002577 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 101510002578 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 101510002579 putative active site [active] 101510002580 oxyanion strand; other site 101510002581 catalytic triad [active] 101510002582 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510002583 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 101510002584 putative active site pocket [active] 101510002585 4-fold oligomerization interface [polypeptide binding]; other site 101510002586 metal binding residues [ion binding]; metal-binding site 101510002587 3-fold/trimer interface [polypeptide binding]; other site 101510002588 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 101510002589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510002590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510002591 homodimer interface [polypeptide binding]; other site 101510002592 catalytic residue [active] 101510002593 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 101510002594 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 101510002595 NAD binding site [chemical binding]; other site 101510002596 dimerization interface [polypeptide binding]; other site 101510002597 product binding site; other site 101510002598 substrate binding site [chemical binding]; other site 101510002599 zinc binding site [ion binding]; other site 101510002600 catalytic residues [active] 101510002601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 101510002602 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 101510002603 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510002604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510002605 active site 101510002606 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 101510002607 beta-galactosidase; Region: BGL; TIGR03356 101510002608 LysE type translocator; Region: LysE; cl00565 101510002609 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 101510002610 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 101510002611 dimerization interface [polypeptide binding]; other site 101510002612 active site 101510002613 L-aspartate oxidase; Provisional; Region: PRK07804 101510002614 L-aspartate oxidase; Provisional; Region: PRK06175 101510002615 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 101510002616 quinolinate synthetase; Provisional; Region: PRK09375 101510002617 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 101510002618 nudix motif; other site 101510002619 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 101510002620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510002621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510002622 WHG domain; Region: WHG; pfam13305 101510002623 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 101510002624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510002625 NAD(P) binding site [chemical binding]; other site 101510002626 active site 101510002627 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 101510002628 biotin synthase; Validated; Region: PRK06256 101510002629 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510002630 FeS/SAM binding site; other site 101510002631 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 101510002632 tetracycline repressor protein TetR; Provisional; Region: PRK13756 101510002633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510002634 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510002635 Secretory lipase; Region: LIP; pfam03583 101510002636 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510002637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510002638 DNA-binding site [nucleotide binding]; DNA binding site 101510002639 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 101510002640 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 101510002641 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 101510002642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510002643 catalytic loop [active] 101510002644 iron binding site [ion binding]; other site 101510002645 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 101510002646 L-aspartate oxidase; Provisional; Region: PRK06175 101510002647 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 101510002648 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510002649 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510002650 active site 101510002651 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 101510002652 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 101510002653 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 101510002654 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510002655 catalytic residue [active] 101510002656 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 101510002657 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510002658 inhibitor-cofactor binding pocket; inhibition site 101510002659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510002660 catalytic residue [active] 101510002661 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 101510002662 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 101510002663 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 101510002664 active site 101510002665 catalytic site [active] 101510002666 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 101510002667 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 101510002668 active site 101510002669 catalytic site [active] 101510002670 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510002671 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 101510002672 putative NAD(P) binding site [chemical binding]; other site 101510002673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510002674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510002675 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 101510002676 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 101510002677 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 101510002678 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 101510002679 catalytic site [active] 101510002680 active site 101510002681 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 101510002682 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 101510002683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510002684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510002685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510002686 threonine dehydratase; Validated; Region: PRK08639 101510002687 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 101510002688 tetramer interface [polypeptide binding]; other site 101510002689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510002690 catalytic residue [active] 101510002691 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 101510002692 pyruvate dehydrogenase; Provisional; Region: PRK06546 101510002693 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 101510002694 PYR/PP interface [polypeptide binding]; other site 101510002695 dimer interface [polypeptide binding]; other site 101510002696 tetramer interface [polypeptide binding]; other site 101510002697 TPP binding site [chemical binding]; other site 101510002698 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510002699 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 101510002700 TPP-binding site [chemical binding]; other site 101510002701 Domain of unknown function (DUF385); Region: DUF385; pfam04075 101510002702 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 101510002703 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 101510002704 active site 101510002705 PHP Thumb interface [polypeptide binding]; other site 101510002706 metal binding site [ion binding]; metal-binding site 101510002707 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 101510002708 generic binding surface II; other site 101510002709 generic binding surface I; other site 101510002710 Predicted permeases [General function prediction only]; Region: RarD; COG2962 101510002711 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 101510002712 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 101510002713 RNA binding surface [nucleotide binding]; other site 101510002714 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 101510002715 active site 101510002716 lipoprotein signal peptidase; Provisional; Region: PRK14764 101510002717 lipoprotein signal peptidase; Provisional; Region: PRK14787 101510002718 PknH-like extracellular domain; Region: PknH_C; pfam14032 101510002719 DNA polymerase IV; Provisional; Region: PRK03348 101510002720 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 101510002721 active site 101510002722 DNA binding site [nucleotide binding] 101510002723 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 101510002724 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 101510002725 HIGH motif; other site 101510002726 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 101510002727 active site 101510002728 KMSKS motif; other site 101510002729 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 101510002730 tRNA binding surface [nucleotide binding]; other site 101510002731 anticodon binding site; other site 101510002732 DivIVA domain; Region: DivI1A_domain; TIGR03544 101510002733 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 101510002734 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 101510002735 Predicted integral membrane protein [Function unknown]; Region: COG0762 101510002736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 101510002737 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 101510002738 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 101510002739 catalytic residue [active] 101510002740 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 101510002741 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 101510002742 cell division protein FtsZ; Validated; Region: PRK09330 101510002743 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 101510002744 nucleotide binding site [chemical binding]; other site 101510002745 SulA interaction site; other site 101510002746 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 101510002747 Cell division protein FtsQ; Region: FtsQ; pfam03799 101510002748 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 101510002749 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 101510002750 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 101510002751 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 101510002752 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 101510002753 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 101510002754 active site 101510002755 homodimer interface [polypeptide binding]; other site 101510002756 cell division protein FtsW; Region: ftsW; TIGR02614 101510002757 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 101510002758 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 101510002759 NAD binding site [chemical binding]; other site 101510002760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 101510002761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 101510002762 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 101510002763 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 101510002764 Mg++ binding site [ion binding]; other site 101510002765 putative catalytic motif [active] 101510002766 putative substrate binding site [chemical binding]; other site 101510002767 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 101510002768 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 101510002769 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 101510002770 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 101510002771 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 101510002772 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 101510002773 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 101510002774 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 101510002775 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 101510002776 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 101510002777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 101510002778 MraW methylase family; Region: Methyltransf_5; cl17771 101510002779 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 101510002780 cell division protein MraZ; Reviewed; Region: PRK00326 101510002781 MraZ protein; Region: MraZ; pfam02381 101510002782 MraZ protein; Region: MraZ; pfam02381 101510002783 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 101510002784 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 101510002785 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 101510002786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510002787 Protein of unknown function (DUF422); Region: DUF422; cl00991 101510002788 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 101510002789 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 101510002790 active site 101510002791 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 101510002792 FAD binding site [chemical binding]; other site 101510002793 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 101510002794 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 101510002795 substrate binding pocket [chemical binding]; other site 101510002796 chain length determination region; other site 101510002797 substrate-Mg2+ binding site; other site 101510002798 catalytic residues [active] 101510002799 aspartate-rich region 1; other site 101510002800 active site lid residues [active] 101510002801 aspartate-rich region 2; other site 101510002802 phytoene desaturase; Region: crtI_fam; TIGR02734 101510002803 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510002804 hydroxyglutarate oxidase; Provisional; Region: PRK11728 101510002805 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 101510002806 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 101510002807 active site lid residues [active] 101510002808 substrate binding pocket [chemical binding]; other site 101510002809 catalytic residues [active] 101510002810 substrate-Mg2+ binding site; other site 101510002811 aspartate-rich region 1; other site 101510002812 aspartate-rich region 2; other site 101510002813 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510002814 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510002815 active site 101510002816 ATP binding site [chemical binding]; other site 101510002817 substrate binding site [chemical binding]; other site 101510002818 activation loop (A-loop); other site 101510002819 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510002820 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 101510002821 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 101510002822 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 101510002823 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 101510002824 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 101510002825 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 101510002826 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 101510002827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 101510002828 putative acyl-acceptor binding pocket; other site 101510002829 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 101510002830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 101510002831 nucleotide binding site [chemical binding]; other site 101510002832 Glucokinase; Region: Glucokinase; cl17310 101510002833 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 101510002834 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 101510002835 DTAP/Switch II; other site 101510002836 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 101510002837 putative hydrophobic ligand binding site [chemical binding]; other site 101510002838 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510002839 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 101510002840 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 101510002841 acyl-activating enzyme (AAE) consensus motif; other site 101510002842 putative AMP binding site [chemical binding]; other site 101510002843 putative active site [active] 101510002844 putative CoA binding site [chemical binding]; other site 101510002845 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510002846 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510002847 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 101510002848 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510002849 NlpC/P60 family; Region: NLPC_P60; pfam00877 101510002850 NlpC/P60 family; Region: NLPC_P60; cl17555 101510002851 hypothetical protein; Validated; Region: PRK07883 101510002852 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 101510002853 active site 101510002854 catalytic site [active] 101510002855 substrate binding site [chemical binding]; other site 101510002856 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 101510002857 GIY-YIG motif/motif A; other site 101510002858 active site 101510002859 catalytic site [active] 101510002860 putative DNA binding site [nucleotide binding]; other site 101510002861 metal binding site [ion binding]; metal-binding site 101510002862 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510002863 AsnC family; Region: AsnC_trans_reg; pfam01037 101510002864 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 101510002865 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 101510002866 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 101510002867 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 101510002868 Subunit I/III interface [polypeptide binding]; other site 101510002869 Cytochrome c; Region: Cytochrom_C; cl11414 101510002870 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 101510002871 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 101510002872 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 101510002873 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 101510002874 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 101510002875 iron-sulfur cluster [ion binding]; other site 101510002876 [2Fe-2S] cluster binding site [ion binding]; other site 101510002877 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 101510002878 heme bH binding site [chemical binding]; other site 101510002879 intrachain domain interface; other site 101510002880 heme bL binding site [chemical binding]; other site 101510002881 interchain domain interface [polypeptide binding]; other site 101510002882 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 101510002883 Qo binding site; other site 101510002884 EamA-like transporter family; Region: EamA; pfam00892 101510002885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510002886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510002887 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 101510002888 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 101510002889 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 101510002890 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 101510002891 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 101510002892 dimer interface [polypeptide binding]; other site 101510002893 active site 101510002894 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 101510002895 Ligand Binding Site [chemical binding]; other site 101510002896 Molecular Tunnel; other site 101510002897 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 101510002898 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 101510002899 substrate binding site [chemical binding]; other site 101510002900 ATP binding site [chemical binding]; other site 101510002901 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 101510002902 Glycerate kinase family; Region: Gly_kinase; cl00841 101510002903 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 101510002904 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 101510002905 homotrimer interface [polypeptide binding]; other site 101510002906 Walker A motif; other site 101510002907 GTP binding site [chemical binding]; other site 101510002908 Walker B motif; other site 101510002909 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 101510002910 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 101510002911 putative dimer interface [polypeptide binding]; other site 101510002912 active site pocket [active] 101510002913 putative cataytic base [active] 101510002914 cobalamin synthase; Reviewed; Region: cobS; PRK00235 101510002915 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 101510002916 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 101510002917 homodimer interface [polypeptide binding]; other site 101510002918 substrate-cofactor binding pocket; other site 101510002919 catalytic residue [active] 101510002920 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 101510002921 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 101510002922 multifunctional aminopeptidase A; Provisional; Region: PRK00913 101510002923 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 101510002924 interface (dimer of trimers) [polypeptide binding]; other site 101510002925 Substrate-binding/catalytic site; other site 101510002926 Zn-binding sites [ion binding]; other site 101510002927 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 101510002928 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 101510002929 E3 interaction surface; other site 101510002930 lipoyl attachment site [posttranslational modification]; other site 101510002931 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 101510002932 E3 interaction surface; other site 101510002933 lipoyl attachment site [posttranslational modification]; other site 101510002934 e3 binding domain; Region: E3_binding; pfam02817 101510002935 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 101510002936 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 101510002937 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 101510002938 putative NAD(P) binding site [chemical binding]; other site 101510002939 putative active site [active] 101510002940 lipoate-protein ligase B; Provisional; Region: PRK14345 101510002941 lipoyl synthase; Provisional; Region: PRK05481 101510002942 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510002943 FeS/SAM binding site; other site 101510002944 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 101510002945 RDD family; Region: RDD; pfam06271 101510002946 glutamine synthetase, type I; Region: GlnA; TIGR00653 101510002947 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 101510002948 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 101510002949 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 101510002950 A new structural DNA glycosylase; Region: AlkD_like; cd06561 101510002951 active site 101510002952 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 101510002953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510002954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 101510002955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 101510002956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510002957 putative PBP binding loops; other site 101510002958 dimer interface [polypeptide binding]; other site 101510002959 ABC-ATPase subunit interface; other site 101510002960 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 101510002961 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 101510002962 Walker A/P-loop; other site 101510002963 ATP binding site [chemical binding]; other site 101510002964 Q-loop/lid; other site 101510002965 ABC transporter signature motif; other site 101510002966 Walker B; other site 101510002967 D-loop; other site 101510002968 H-loop/switch region; other site 101510002969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510002970 dimer interface [polypeptide binding]; other site 101510002971 conserved gate region; other site 101510002972 putative PBP binding loops; other site 101510002973 ABC-ATPase subunit interface; other site 101510002974 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 101510002975 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 101510002976 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 101510002977 putative catalytic site [active] 101510002978 putative metal binding site [ion binding]; other site 101510002979 putative phosphate binding site [ion binding]; other site 101510002980 putative catalytic site [active] 101510002981 putative phosphate binding site [ion binding]; other site 101510002982 putative metal binding site [ion binding]; other site 101510002983 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 101510002984 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 101510002985 metal binding triad; other site 101510002986 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 101510002987 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 101510002988 metal binding triad [ion binding]; metal-binding site 101510002989 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 101510002990 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 101510002991 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 101510002992 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 101510002993 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510002994 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510002995 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 101510002996 oligomerization interface [polypeptide binding]; other site 101510002997 active site 101510002998 metal binding site [ion binding]; metal-binding site 101510002999 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 101510003000 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510003001 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510003002 RNB domain; Region: RNB; pfam00773 101510003003 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 101510003004 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 101510003005 active site 101510003006 catalytic site [active] 101510003007 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510003008 active site 2 [active] 101510003009 active site 1 [active] 101510003010 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 101510003011 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510003012 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 101510003013 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 101510003014 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 101510003015 transmembrane helices; other site 101510003016 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 101510003017 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 101510003018 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 101510003019 RNA/DNA hybrid binding site [nucleotide binding]; other site 101510003020 active site 101510003021 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510003022 catalytic core [active] 101510003023 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 101510003024 Putative zinc ribbon domain; Region: DUF164; pfam02591 101510003025 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 101510003026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 101510003027 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 101510003028 hypothetical protein; Provisional; Region: PRK07908 101510003029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510003030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510003031 homodimer interface [polypeptide binding]; other site 101510003032 catalytic residue [active] 101510003033 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 101510003034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510003035 motif II; other site 101510003036 Low molecular weight phosphatase family; Region: LMWPc; cd00115 101510003037 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 101510003038 active site 101510003039 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 101510003040 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 101510003041 Predicted transcriptional regulators [Transcription]; Region: COG1510 101510003042 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 101510003043 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 101510003044 dimer interface [polypeptide binding]; other site 101510003045 catalytic triad [active] 101510003046 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 101510003047 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 101510003048 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 101510003049 dimer interface [polypeptide binding]; other site 101510003050 TPP-binding site [chemical binding]; other site 101510003051 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 101510003052 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510003053 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 101510003054 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 101510003055 acyl carrier protein; Provisional; Region: acpP; PRK00982 101510003056 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 101510003057 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 101510003058 dimer interface [polypeptide binding]; other site 101510003059 active site 101510003060 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 101510003061 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510003062 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 101510003063 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 101510003064 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510003065 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510003066 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 101510003067 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 101510003068 NAD binding site [chemical binding]; other site 101510003069 catalytic Zn binding site [ion binding]; other site 101510003070 substrate binding site [chemical binding]; other site 101510003071 structural Zn binding site [ion binding]; other site 101510003072 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 101510003073 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 101510003074 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 101510003075 Domain of unknown function DUF20; Region: UPF0118; pfam01594 101510003076 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 101510003077 DNA primase; Validated; Region: dnaG; PRK05667 101510003078 CHC2 zinc finger; Region: zf-CHC2; pfam01807 101510003079 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 101510003080 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 101510003081 active site 101510003082 metal binding site [ion binding]; metal-binding site 101510003083 interdomain interaction site; other site 101510003084 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 101510003085 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 101510003086 Secretory lipase; Region: LIP; pfam03583 101510003087 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 101510003088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 101510003089 Zn2+ binding site [ion binding]; other site 101510003090 Mg2+ binding site [ion binding]; other site 101510003091 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 101510003092 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 101510003093 putative active site [active] 101510003094 Repair protein; Region: Repair_PSII; pfam04536 101510003095 glycyl-tRNA synthetase; Provisional; Region: PRK04173 101510003096 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 101510003097 motif 1; other site 101510003098 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 101510003099 active site 101510003100 motif 2; other site 101510003101 motif 3; other site 101510003102 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 101510003103 anticodon binding site; other site 101510003104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510003105 dimerization interface [polypeptide binding]; other site 101510003106 putative DNA binding site [nucleotide binding]; other site 101510003107 putative Zn2+ binding site [ion binding]; other site 101510003108 ferric uptake regulator; Provisional; Region: fur; PRK09462 101510003109 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 101510003110 metal binding site 2 [ion binding]; metal-binding site 101510003111 putative DNA binding helix; other site 101510003112 metal binding site 1 [ion binding]; metal-binding site 101510003113 dimer interface [polypeptide binding]; other site 101510003114 structural Zn2+ binding site [ion binding]; other site 101510003115 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 101510003116 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 101510003117 catalytic residue [active] 101510003118 putative FPP diphosphate binding site; other site 101510003119 putative FPP binding hydrophobic cleft; other site 101510003120 dimer interface [polypeptide binding]; other site 101510003121 putative IPP diphosphate binding site; other site 101510003122 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 101510003123 Recombination protein O N terminal; Region: RecO_N; pfam11967 101510003124 Recombination protein O C terminal; Region: RecO_C; pfam02565 101510003125 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510003126 PGAP1-like protein; Region: PGAP1; pfam07819 101510003127 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 101510003128 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 101510003129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510003130 active site 101510003131 phosphorylation site [posttranslational modification] 101510003132 intermolecular recognition site; other site 101510003133 dimerization interface [polypeptide binding]; other site 101510003134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510003135 DNA binding site [nucleotide binding] 101510003136 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 101510003137 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 101510003138 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 101510003139 Ligand Binding Site [chemical binding]; other site 101510003140 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 101510003141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510003142 dimer interface [polypeptide binding]; other site 101510003143 phosphorylation site [posttranslational modification] 101510003144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510003145 ATP binding site [chemical binding]; other site 101510003146 Mg2+ binding site [ion binding]; other site 101510003147 G-X-G motif; other site 101510003148 K+-transporting ATPase, c chain; Region: KdpC; cl00944 101510003149 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 101510003150 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510003151 Soluble P-type ATPase [General function prediction only]; Region: COG4087 101510003152 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 101510003153 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 101510003154 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 101510003155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510003156 DNA-binding site [nucleotide binding]; DNA binding site 101510003157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510003158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510003159 homodimer interface [polypeptide binding]; other site 101510003160 catalytic residue [active] 101510003161 amidase; Provisional; Region: PRK06061 101510003162 Amidase; Region: Amidase; cl11426 101510003163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510003164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510003165 GTPase Era; Reviewed; Region: era; PRK00089 101510003166 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 101510003167 G1 box; other site 101510003168 GTP/Mg2+ binding site [chemical binding]; other site 101510003169 Switch I region; other site 101510003170 G2 box; other site 101510003171 Switch II region; other site 101510003172 G3 box; other site 101510003173 G4 box; other site 101510003174 G5 box; other site 101510003175 KH domain; Region: KH_2; pfam07650 101510003176 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 101510003177 Domain of unknown function DUF21; Region: DUF21; pfam01595 101510003178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 101510003179 Transporter associated domain; Region: CorC_HlyC; smart01091 101510003180 metal-binding heat shock protein; Provisional; Region: PRK00016 101510003181 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 101510003182 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 101510003183 PhoH-like protein; Region: PhoH; pfam02562 101510003184 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 101510003185 metal binding site [ion binding]; metal-binding site 101510003186 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510003187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510003188 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 101510003189 RNA methyltransferase, RsmE family; Region: TIGR00046 101510003190 chaperone protein DnaJ; Provisional; Region: PRK14278 101510003191 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 101510003192 HSP70 interaction site [polypeptide binding]; other site 101510003193 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 101510003194 Zn binding sites [ion binding]; other site 101510003195 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 101510003196 dimer interface [polypeptide binding]; other site 101510003197 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 101510003198 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 101510003199 coproporphyrinogen III oxidase; Validated; Region: PRK05628 101510003200 HemN C-terminal domain; Region: HemN_C; pfam06969 101510003201 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 101510003202 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 101510003203 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 101510003204 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 101510003205 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 101510003206 Active Sites [active] 101510003207 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 101510003208 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 101510003209 Active Sites [active] 101510003210 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 101510003211 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 101510003212 CysD dimerization site [polypeptide binding]; other site 101510003213 G1 box; other site 101510003214 putative GEF interaction site [polypeptide binding]; other site 101510003215 GTP/Mg2+ binding site [chemical binding]; other site 101510003216 Switch I region; other site 101510003217 G2 box; other site 101510003218 G3 box; other site 101510003219 Switch II region; other site 101510003220 G4 box; other site 101510003221 G5 box; other site 101510003222 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 101510003223 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 101510003224 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 101510003225 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 101510003226 putative active site [active] 101510003227 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 101510003228 putative active site [active] 101510003229 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510003230 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 101510003231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510003232 homodimer interface [polypeptide binding]; other site 101510003233 catalytic residue [active] 101510003234 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 101510003235 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 101510003236 active site 101510003237 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 101510003238 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510003239 PYR/PP interface [polypeptide binding]; other site 101510003240 dimer interface [polypeptide binding]; other site 101510003241 TPP binding site [chemical binding]; other site 101510003242 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510003243 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 101510003244 TPP-binding site [chemical binding]; other site 101510003245 Putative zinc-finger; Region: zf-HC2; pfam13490 101510003246 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 101510003247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510003248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510003249 DNA binding residues [nucleotide binding] 101510003250 Uncharacterized conserved protein [Function unknown]; Region: COG5649 101510003251 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510003252 Ligand Binding Site [chemical binding]; other site 101510003253 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510003254 Ligand Binding Site [chemical binding]; other site 101510003255 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 101510003256 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 101510003257 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 101510003258 Active Sites [active] 101510003259 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 101510003260 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 101510003261 CysD dimerization site [polypeptide binding]; other site 101510003262 G1 box; other site 101510003263 putative GEF interaction site [polypeptide binding]; other site 101510003264 GTP/Mg2+ binding site [chemical binding]; other site 101510003265 Switch I region; other site 101510003266 G2 box; other site 101510003267 G3 box; other site 101510003268 Switch II region; other site 101510003269 G4 box; other site 101510003270 G5 box; other site 101510003271 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 101510003272 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 101510003273 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 101510003274 ligand-binding site [chemical binding]; other site 101510003275 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 101510003276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 101510003277 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 101510003278 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 101510003279 Sulfatase; Region: Sulfatase; pfam00884 101510003280 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 101510003281 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 101510003282 Walker A/P-loop; other site 101510003283 ATP binding site [chemical binding]; other site 101510003284 Q-loop/lid; other site 101510003285 ABC transporter signature motif; other site 101510003286 Walker B; other site 101510003287 D-loop; other site 101510003288 H-loop/switch region; other site 101510003289 TOBE domain; Region: TOBE; pfam03459 101510003290 sulfate transport protein; Provisional; Region: cysT; CHL00187 101510003291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510003292 dimer interface [polypeptide binding]; other site 101510003293 conserved gate region; other site 101510003294 putative PBP binding loops; other site 101510003295 ABC-ATPase subunit interface; other site 101510003296 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 101510003297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510003298 dimer interface [polypeptide binding]; other site 101510003299 conserved gate region; other site 101510003300 putative PBP binding loops; other site 101510003301 ABC-ATPase subunit interface; other site 101510003302 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 101510003303 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 101510003304 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 101510003305 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 101510003306 Nitronate monooxygenase; Region: NMO; pfam03060 101510003307 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510003308 FMN binding site [chemical binding]; other site 101510003309 substrate binding site [chemical binding]; other site 101510003310 putative catalytic residue [active] 101510003311 GTP-binding protein LepA; Provisional; Region: PRK05433 101510003312 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 101510003313 G1 box; other site 101510003314 putative GEF interaction site [polypeptide binding]; other site 101510003315 GTP/Mg2+ binding site [chemical binding]; other site 101510003316 Switch I region; other site 101510003317 G2 box; other site 101510003318 G3 box; other site 101510003319 Switch II region; other site 101510003320 G4 box; other site 101510003321 G5 box; other site 101510003322 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 101510003323 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 101510003324 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 101510003325 PemK-like protein; Region: PemK; pfam02452 101510003326 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 101510003327 active site 101510003328 catalytic triad [active] 101510003329 oxyanion hole [active] 101510003330 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 101510003331 amphipathic channel; other site 101510003332 Asn-Pro-Ala signature motifs; other site 101510003333 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 101510003334 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 101510003335 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 101510003336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 101510003337 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 101510003338 Uncharacterized conserved protein [Function unknown]; Region: COG2308 101510003339 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 101510003340 hypothetical protein; Reviewed; Region: PRK07914 101510003341 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 101510003342 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 101510003343 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 101510003344 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510003345 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 101510003346 substrate binding pocket [chemical binding]; other site 101510003347 catalytic triad [active] 101510003348 ANTAR domain; Region: ANTAR; pfam03861 101510003349 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510003350 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 101510003351 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 101510003352 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 101510003353 Competence protein; Region: Competence; pfam03772 101510003354 SLBB domain; Region: SLBB; pfam10531 101510003355 comEA protein; Region: comE; TIGR01259 101510003356 Helix-hairpin-helix motif; Region: HHH; pfam00633 101510003357 EDD domain protein, DegV family; Region: DegV; TIGR00762 101510003358 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 101510003359 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 101510003360 active site 101510003361 catalytic triad [active] 101510003362 oxyanion hole [active] 101510003363 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510003364 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 101510003365 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 101510003366 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 101510003367 active site 101510003368 (T/H)XGH motif; other site 101510003369 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 101510003370 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 101510003371 metal ion-dependent adhesion site (MIDAS); other site 101510003372 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 101510003373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510003374 Walker A motif; other site 101510003375 ATP binding site [chemical binding]; other site 101510003376 Walker B motif; other site 101510003377 arginine finger; other site 101510003378 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 101510003379 putative catalytic cysteine [active] 101510003380 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510003381 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 101510003382 active site 101510003383 FMN binding site [chemical binding]; other site 101510003384 substrate binding site [chemical binding]; other site 101510003385 homotetramer interface [polypeptide binding]; other site 101510003386 catalytic residue [active] 101510003387 proline/glycine betaine transporter; Provisional; Region: PRK10642 101510003388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510003389 putative substrate translocation pore; other site 101510003390 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 101510003391 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 101510003392 substrate binding site [chemical binding]; other site 101510003393 ATP binding site [chemical binding]; other site 101510003394 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 101510003395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510003396 ATP binding site [chemical binding]; other site 101510003397 putative Mg++ binding site [ion binding]; other site 101510003398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510003399 nucleotide binding region [chemical binding]; other site 101510003400 ATP-binding site [chemical binding]; other site 101510003401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 101510003402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510003403 Coenzyme A binding pocket [chemical binding]; other site 101510003404 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 101510003405 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510003406 inhibitor-cofactor binding pocket; inhibition site 101510003407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510003408 catalytic residue [active] 101510003409 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 101510003410 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 101510003411 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 101510003412 putative ligand binding site [chemical binding]; other site 101510003413 putative NAD binding site [chemical binding]; other site 101510003414 catalytic site [active] 101510003415 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 101510003416 NAD+ binding site [chemical binding]; other site 101510003417 substrate binding site [chemical binding]; other site 101510003418 Zn binding site [ion binding]; other site 101510003419 gamma-glutamyl kinase; Provisional; Region: PRK05429 101510003420 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 101510003421 nucleotide binding site [chemical binding]; other site 101510003422 homotetrameric interface [polypeptide binding]; other site 101510003423 putative phosphate binding site [ion binding]; other site 101510003424 putative allosteric binding site; other site 101510003425 PUA domain; Region: PUA; pfam01472 101510003426 GTPase CgtA; Reviewed; Region: obgE; PRK12296 101510003427 GTP1/OBG; Region: GTP1_OBG; pfam01018 101510003428 Obg GTPase; Region: Obg; cd01898 101510003429 G1 box; other site 101510003430 GTP/Mg2+ binding site [chemical binding]; other site 101510003431 Switch I region; other site 101510003432 G2 box; other site 101510003433 G3 box; other site 101510003434 Switch II region; other site 101510003435 G4 box; other site 101510003436 G5 box; other site 101510003437 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 101510003438 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 101510003439 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 101510003440 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 101510003441 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 101510003442 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 101510003443 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 101510003444 homodimer interface [polypeptide binding]; other site 101510003445 oligonucleotide binding site [chemical binding]; other site 101510003446 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 101510003447 active site 101510003448 multimer interface [polypeptide binding]; other site 101510003449 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 101510003450 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 101510003451 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 101510003452 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 101510003453 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 101510003454 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 101510003455 HIGH motif; other site 101510003456 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 101510003457 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 101510003458 active site 101510003459 KMSKS motif; other site 101510003460 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 101510003461 tRNA binding surface [nucleotide binding]; other site 101510003462 anticodon binding site; other site 101510003463 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 101510003464 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 101510003465 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 101510003466 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510003467 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 101510003468 Na binding site [ion binding]; other site 101510003469 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 101510003470 homotrimer interaction site [polypeptide binding]; other site 101510003471 putative active site [active] 101510003472 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 101510003473 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 101510003474 putative hydrophobic ligand binding site [chemical binding]; other site 101510003475 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 101510003476 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510003477 active site 101510003478 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 101510003479 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510003480 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 101510003481 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 101510003482 siderophore binding site; other site 101510003483 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 101510003484 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 101510003485 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 101510003486 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 101510003487 heterodimer interface [polypeptide binding]; other site 101510003488 multimer interface [polypeptide binding]; other site 101510003489 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 101510003490 active site 101510003491 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 101510003492 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 101510003493 heterodimer interface [polypeptide binding]; other site 101510003494 active site 101510003495 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 101510003496 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 101510003497 tetramer interface [polypeptide binding]; other site 101510003498 active site 101510003499 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 101510003500 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 101510003501 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 101510003502 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510003503 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510003504 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 101510003505 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510003506 dimer interface [polypeptide binding]; other site 101510003507 active site 101510003508 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 101510003509 active site 101510003510 metal binding site [ion binding]; metal-binding site 101510003511 homotetramer interface [polypeptide binding]; other site 101510003512 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 101510003513 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 101510003514 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 101510003515 shikimate binding site; other site 101510003516 NAD(P) binding site [chemical binding]; other site 101510003517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510003518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510003519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510003520 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510003521 putative substrate translocation pore; other site 101510003522 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 101510003523 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510003524 Walker A/P-loop; other site 101510003525 ATP binding site [chemical binding]; other site 101510003526 Q-loop/lid; other site 101510003527 ABC transporter signature motif; other site 101510003528 Walker B; other site 101510003529 D-loop; other site 101510003530 H-loop/switch region; other site 101510003531 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510003532 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510003533 TM-ABC transporter signature motif; other site 101510003534 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 101510003535 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510003536 putative ligand binding site [chemical binding]; other site 101510003537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510003538 putative transporter; Provisional; Region: PRK10504 101510003539 putative substrate translocation pore; other site 101510003540 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510003541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510003542 DNA-binding site [nucleotide binding]; DNA binding site 101510003543 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 101510003544 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 101510003545 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 101510003546 substrate binding site [chemical binding]; other site 101510003547 ATP binding site [chemical binding]; other site 101510003548 KduI/IolB family; Region: KduI; pfam04962 101510003549 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 101510003550 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510003551 PYR/PP interface [polypeptide binding]; other site 101510003552 dimer interface [polypeptide binding]; other site 101510003553 TPP binding site [chemical binding]; other site 101510003554 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510003555 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 101510003556 TPP-binding site; other site 101510003557 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 101510003558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510003559 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510003560 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510003561 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 101510003562 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 101510003563 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 101510003564 tetrameric interface [polypeptide binding]; other site 101510003565 NAD binding site [chemical binding]; other site 101510003566 catalytic residues [active] 101510003567 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510003568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510003569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510003570 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 101510003571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 101510003572 nucleotide binding site [chemical binding]; other site 101510003573 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 101510003574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510003575 putative substrate translocation pore; other site 101510003576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510003577 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510003578 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510003579 DNA binding site [nucleotide binding] 101510003580 domain linker motif; other site 101510003581 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 101510003582 dimerization interface [polypeptide binding]; other site 101510003583 ligand binding site [chemical binding]; other site 101510003584 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 101510003585 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 101510003586 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 101510003587 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510003588 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510003589 DNA binding site [nucleotide binding] 101510003590 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 101510003591 putative ligand binding site [chemical binding]; other site 101510003592 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510003593 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510003594 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510003595 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 101510003596 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 101510003597 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 101510003598 active site 101510003599 Fe binding site [ion binding]; other site 101510003600 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 101510003601 Dehydroquinase class II; Region: DHquinase_II; pfam01220 101510003602 trimer interface [polypeptide binding]; other site 101510003603 active site 101510003604 dimer interface [polypeptide binding]; other site 101510003605 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 101510003606 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 101510003607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510003608 Walker A motif; other site 101510003609 ATP binding site [chemical binding]; other site 101510003610 Walker B motif; other site 101510003611 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 101510003612 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 101510003613 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 101510003614 oligomer interface [polypeptide binding]; other site 101510003615 active site residues [active] 101510003616 Clp protease; Region: CLP_protease; pfam00574 101510003617 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 101510003618 oligomer interface [polypeptide binding]; other site 101510003619 active site residues [active] 101510003620 trigger factor; Provisional; Region: tig; PRK01490 101510003621 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 101510003622 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 101510003623 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 101510003624 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 101510003625 putative DNA binding site [nucleotide binding]; other site 101510003626 catalytic residue [active] 101510003627 putative H2TH interface [polypeptide binding]; other site 101510003628 putative catalytic residues [active] 101510003629 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 101510003630 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 101510003631 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 101510003632 Peptidase family M48; Region: Peptidase_M48; pfam01435 101510003633 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 101510003634 catalytic residues [active] 101510003635 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510003636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510003637 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 101510003638 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 101510003639 Zn binding site [ion binding]; other site 101510003640 DNA polymerase IV; Validated; Region: PRK03858 101510003641 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 101510003642 active site 101510003643 DNA binding site [nucleotide binding] 101510003644 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510003645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510003646 Repair protein; Region: Repair_PSII; pfam04536 101510003647 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 101510003648 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510003649 active site 101510003650 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 101510003651 apolar tunnel; other site 101510003652 heme binding site [chemical binding]; other site 101510003653 dimerization interface [polypeptide binding]; other site 101510003654 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 101510003655 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 101510003656 active site 101510003657 catalytic site [active] 101510003658 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 101510003659 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 101510003660 active site 101510003661 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 101510003662 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 101510003663 active site 101510003664 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 101510003665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510003666 Walker A/P-loop; other site 101510003667 ATP binding site [chemical binding]; other site 101510003668 Q-loop/lid; other site 101510003669 ABC transporter signature motif; other site 101510003670 Walker B; other site 101510003671 D-loop; other site 101510003672 H-loop/switch region; other site 101510003673 ABC transporter; Region: ABC_tran_2; pfam12848 101510003674 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 101510003675 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 101510003676 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 101510003677 dimer interface [polypeptide binding]; other site 101510003678 ssDNA binding site [nucleotide binding]; other site 101510003679 tetramer (dimer of dimers) interface [polypeptide binding]; other site 101510003680 Copper resistance protein D; Region: CopD; pfam05425 101510003681 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 101510003682 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510003683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510003684 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510003685 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510003686 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510003687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510003688 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510003689 CoenzymeA binding site [chemical binding]; other site 101510003690 subunit interaction site [polypeptide binding]; other site 101510003691 PHB binding site; other site 101510003692 short chain dehydrogenase; Validated; Region: PRK08264 101510003693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510003694 NAD(P) binding site [chemical binding]; other site 101510003695 active site 101510003696 Predicted transcriptional regulators [Transcription]; Region: COG1733 101510003697 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 101510003698 glutamate dehydrogenase; Provisional; Region: PRK09414 101510003699 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 101510003700 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 101510003701 NAD(P) binding site [chemical binding]; other site 101510003702 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 101510003703 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 101510003704 putative di-iron ligands [ion binding]; other site 101510003705 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 101510003706 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510003707 FAD binding pocket [chemical binding]; other site 101510003708 FAD binding motif [chemical binding]; other site 101510003709 phosphate binding motif [ion binding]; other site 101510003710 beta-alpha-beta structure motif; other site 101510003711 NAD binding pocket [chemical binding]; other site 101510003712 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510003713 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510003714 catalytic loop [active] 101510003715 iron binding site [ion binding]; other site 101510003716 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 101510003717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510003718 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510003719 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510003720 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 101510003721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510003722 putative substrate translocation pore; other site 101510003723 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510003724 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 101510003725 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 101510003726 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510003727 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 101510003728 active site 101510003729 FMN binding site [chemical binding]; other site 101510003730 2,4-decadienoyl-CoA binding site; other site 101510003731 catalytic residue [active] 101510003732 4Fe-4S cluster binding site [ion binding]; other site 101510003733 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 101510003734 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 101510003735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510003736 NAD(P) binding site [chemical binding]; other site 101510003737 active site 101510003738 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 101510003739 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 101510003740 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 101510003741 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 101510003742 catalytic site [active] 101510003743 putative active site [active] 101510003744 putative substrate binding site [chemical binding]; other site 101510003745 dimer interface [polypeptide binding]; other site 101510003746 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 101510003747 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 101510003748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 101510003749 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 101510003750 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 101510003751 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 101510003752 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 101510003753 catalytic triad [active] 101510003754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510003755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510003756 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 101510003757 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 101510003758 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 101510003759 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510003760 phosphate binding site [ion binding]; other site 101510003761 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 101510003762 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510003763 active site 2 [active] 101510003764 active site 1 [active] 101510003765 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 101510003766 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 101510003767 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 101510003768 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 101510003769 putative NAD(P) binding site [chemical binding]; other site 101510003770 active site 101510003771 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 101510003772 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 101510003773 active site 101510003774 Glucitol operon activator protein (GutM); Region: GutM; cl01890 101510003775 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 101510003776 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 101510003777 active site 101510003778 dimerization interface [polypeptide binding]; other site 101510003779 ribonuclease PH; Reviewed; Region: rph; PRK00173 101510003780 Ribonuclease PH; Region: RNase_PH_bact; cd11362 101510003781 hexamer interface [polypeptide binding]; other site 101510003782 active site 101510003783 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 101510003784 Rhomboid family; Region: Rhomboid; pfam01694 101510003785 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 101510003786 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 101510003787 dimer interface [polypeptide binding]; other site 101510003788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510003789 catalytic residue [active] 101510003790 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 101510003791 MoaE interaction surface [polypeptide binding]; other site 101510003792 MoeB interaction surface [polypeptide binding]; other site 101510003793 thiocarboxylated glycine; other site 101510003794 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 101510003795 MPN+ (JAMM) motif; other site 101510003796 Zinc-binding site [ion binding]; other site 101510003797 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 101510003798 putative active site pocket [active] 101510003799 cleavage site 101510003800 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 101510003801 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 101510003802 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 101510003803 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 101510003804 active site 101510003805 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 101510003806 Isochorismatase family; Region: Isochorismatase; pfam00857 101510003807 catalytic triad [active] 101510003808 metal binding site [ion binding]; metal-binding site 101510003809 conserved cis-peptide bond; other site 101510003810 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 101510003811 DEAD/DEAH box helicase; Region: DEAD; pfam00270 101510003812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 101510003813 putative Mg++ binding site [ion binding]; other site 101510003814 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 101510003815 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 101510003816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 101510003817 Walker A/P-loop; other site 101510003818 ATP binding site [chemical binding]; other site 101510003819 Q-loop/lid; other site 101510003820 ABC transporter signature motif; other site 101510003821 Walker B; other site 101510003822 D-loop; other site 101510003823 H-loop/switch region; other site 101510003824 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 101510003825 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 101510003826 putative homodimer interface [polypeptide binding]; other site 101510003827 putative active site pocket [active] 101510003828 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 101510003829 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 101510003830 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 101510003831 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 101510003832 active site 101510003833 homodimer interface [polypeptide binding]; other site 101510003834 catalytic site [active] 101510003835 acceptor binding site [chemical binding]; other site 101510003836 glycogen branching enzyme; Provisional; Region: PRK05402 101510003837 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 101510003838 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 101510003839 active site 101510003840 catalytic site [active] 101510003841 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 101510003842 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 101510003843 D-galactonate transporter; Region: 2A0114; TIGR00893 101510003844 D-galactonate transporter; Region: 2A0114; TIGR00893 101510003845 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 101510003846 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 101510003847 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 101510003848 putative acyltransferase; Provisional; Region: PRK05790 101510003849 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510003850 dimer interface [polypeptide binding]; other site 101510003851 active site 101510003852 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 101510003853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510003854 dimer interface [polypeptide binding]; other site 101510003855 substrate binding site [chemical binding]; other site 101510003856 metal binding site [ion binding]; metal-binding site 101510003857 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 101510003858 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 101510003859 hypothetical protein; Provisional; Region: PRK03298 101510003860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510003861 dimerization interface [polypeptide binding]; other site 101510003862 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 101510003863 cyclase homology domain; Region: CHD; cd07302 101510003864 nucleotidyl binding site; other site 101510003865 metal binding site [ion binding]; metal-binding site 101510003866 dimer interface [polypeptide binding]; other site 101510003867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510003868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510003869 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510003870 Uncharacterized conserved protein [Function unknown]; Region: COG4279 101510003871 SWIM zinc finger; Region: SWIM; pfam04434 101510003872 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 101510003873 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 101510003874 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510003875 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 101510003876 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 101510003877 hinge; other site 101510003878 active site 101510003879 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 101510003880 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 101510003881 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 101510003882 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 101510003883 gamma subunit interface [polypeptide binding]; other site 101510003884 epsilon subunit interface [polypeptide binding]; other site 101510003885 LBP interface [polypeptide binding]; other site 101510003886 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 101510003887 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 101510003888 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 101510003889 alpha subunit interaction interface [polypeptide binding]; other site 101510003890 Walker A motif; other site 101510003891 ATP binding site [chemical binding]; other site 101510003892 Walker B motif; other site 101510003893 inhibitor binding site; inhibition site 101510003894 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 101510003895 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 101510003896 core domain interface [polypeptide binding]; other site 101510003897 delta subunit interface [polypeptide binding]; other site 101510003898 epsilon subunit interface [polypeptide binding]; other site 101510003899 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 101510003900 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 101510003901 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 101510003902 beta subunit interaction interface [polypeptide binding]; other site 101510003903 Walker A motif; other site 101510003904 ATP binding site [chemical binding]; other site 101510003905 Walker B motif; other site 101510003906 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 101510003907 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 101510003908 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 101510003909 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 101510003910 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 101510003911 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 101510003912 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 101510003913 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 101510003914 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 101510003915 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 101510003916 Mg++ binding site [ion binding]; other site 101510003917 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 101510003918 putative catalytic motif [active] 101510003919 substrate binding site [chemical binding]; other site 101510003920 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 101510003921 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 101510003922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510003923 S-adenosylmethionine binding site [chemical binding]; other site 101510003924 peptide chain release factor 1; Validated; Region: prfA; PRK00591 101510003925 This domain is found in peptide chain release factors; Region: PCRF; smart00937 101510003926 RF-1 domain; Region: RF-1; pfam00472 101510003927 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 101510003928 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 101510003929 transcription termination factor Rho; Provisional; Region: PRK12608 101510003930 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 101510003931 RNA binding site [nucleotide binding]; other site 101510003932 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 101510003933 multimer interface [polypeptide binding]; other site 101510003934 Walker A motif; other site 101510003935 ATP binding site [chemical binding]; other site 101510003936 Walker B motif; other site 101510003937 homoserine kinase; Provisional; Region: PRK01212 101510003938 threonine synthase; Reviewed; Region: PRK06721 101510003939 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 101510003940 homodimer interface [polypeptide binding]; other site 101510003941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510003942 catalytic residue [active] 101510003943 homoserine dehydrogenase; Provisional; Region: PRK06349 101510003944 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 101510003945 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 101510003946 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 101510003947 diaminopimelate decarboxylase; Region: lysA; TIGR01048 101510003948 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 101510003949 active site 101510003950 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 101510003951 substrate binding site [chemical binding]; other site 101510003952 catalytic residues [active] 101510003953 dimer interface [polypeptide binding]; other site 101510003954 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 101510003955 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 101510003956 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 101510003957 active site 101510003958 HIGH motif; other site 101510003959 KMSK motif region; other site 101510003960 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 101510003961 tRNA binding surface [nucleotide binding]; other site 101510003962 anticodon binding site; other site 101510003963 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 101510003964 Domain of unknown function (DUF305); Region: DUF305; pfam03713 101510003965 putative phosphoketolase; Provisional; Region: PRK05261 101510003966 XFP N-terminal domain; Region: XFP_N; pfam09364 101510003967 XFP C-terminal domain; Region: XFP_C; pfam09363 101510003968 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 101510003969 putative active site [active] 101510003970 putative ligand binding site [chemical binding]; other site 101510003971 putative NAD(P) binding site [chemical binding]; other site 101510003972 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 101510003973 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 101510003974 acyl-activating enzyme (AAE) consensus motif; other site 101510003975 putative AMP binding site [chemical binding]; other site 101510003976 putative active site [active] 101510003977 putative CoA binding site [chemical binding]; other site 101510003978 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 101510003979 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 101510003980 NADP binding site [chemical binding]; other site 101510003981 active site 101510003982 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510003983 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 101510003984 NAD(P) binding site [chemical binding]; other site 101510003985 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510003986 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510003987 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510003988 active site 101510003989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510003990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510003991 active site 101510003992 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510003993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510003994 NAD(P) binding site [chemical binding]; other site 101510003995 active site 101510003996 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510003997 putative active site [active] 101510003998 putative substrate binding site [chemical binding]; other site 101510003999 ATP binding site [chemical binding]; other site 101510004000 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510004001 classical (c) SDRs; Region: SDR_c; cd05233 101510004002 NAD(P) binding site [chemical binding]; other site 101510004003 active site 101510004004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510004005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510004006 active site 101510004007 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510004008 enoyl-CoA hydratase; Provisional; Region: PRK06210 101510004009 substrate binding site [chemical binding]; other site 101510004010 oxyanion hole (OAH) forming residues; other site 101510004011 trimer interface [polypeptide binding]; other site 101510004012 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 101510004013 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510004014 classical (c) SDRs; Region: SDR_c; cd05233 101510004015 NAD(P) binding site [chemical binding]; other site 101510004016 active site 101510004017 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 101510004018 putative active site [active] 101510004019 putative catalytic site [active] 101510004020 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 101510004021 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 101510004022 acyl-activating enzyme (AAE) consensus motif; other site 101510004023 putative AMP binding site [chemical binding]; other site 101510004024 putative active site [active] 101510004025 putative CoA binding site [chemical binding]; other site 101510004026 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 101510004027 Prostaglandin dehydrogenases; Region: PGDH; cd05288 101510004028 NAD(P) binding site [chemical binding]; other site 101510004029 substrate binding site [chemical binding]; other site 101510004030 dimer interface [polypeptide binding]; other site 101510004031 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510004032 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 101510004033 NAD(P) binding site [chemical binding]; other site 101510004034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004035 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510004036 putative substrate translocation pore; other site 101510004037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510004038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510004039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510004040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510004041 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 101510004042 active site 101510004043 substrate binding pocket [chemical binding]; other site 101510004044 homodimer interaction site [polypeptide binding]; other site 101510004045 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 101510004046 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510004047 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 101510004048 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 101510004049 active site 101510004050 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 101510004051 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 101510004052 CysD dimerization site [polypeptide binding]; other site 101510004053 G1 box; other site 101510004054 putative GEF interaction site [polypeptide binding]; other site 101510004055 GTP/Mg2+ binding site [chemical binding]; other site 101510004056 Switch I region; other site 101510004057 G2 box; other site 101510004058 G3 box; other site 101510004059 Switch II region; other site 101510004060 G4 box; other site 101510004061 G5 box; other site 101510004062 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 101510004063 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 101510004064 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 101510004065 ligand-binding site [chemical binding]; other site 101510004066 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 101510004067 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 101510004068 Active Sites [active] 101510004069 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510004070 short chain dehydrogenase; Provisional; Region: PRK07890 101510004071 classical (c) SDRs; Region: SDR_c; cd05233 101510004072 NAD(P) binding site [chemical binding]; other site 101510004073 active site 101510004074 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 101510004075 Low molecular weight phosphatase family; Region: LMWPc; cl00105 101510004076 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 101510004077 active site 101510004078 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 101510004079 Clp protease; Region: CLP_protease; pfam00574 101510004080 oligomer interface [polypeptide binding]; other site 101510004081 active site residues [active] 101510004082 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 101510004083 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 101510004084 oligomer interface [polypeptide binding]; other site 101510004085 active site residues [active] 101510004086 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510004087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510004088 non-specific DNA binding site [nucleotide binding]; other site 101510004089 salt bridge; other site 101510004090 sequence-specific DNA binding site [nucleotide binding]; other site 101510004091 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510004092 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510004093 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510004094 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 101510004095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510004096 active site 101510004097 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510004098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510004099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510004100 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 101510004101 putative hydrophobic ligand binding site [chemical binding]; other site 101510004102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510004103 putative DNA binding site [nucleotide binding]; other site 101510004104 dimerization interface [polypeptide binding]; other site 101510004105 putative Zn2+ binding site [ion binding]; other site 101510004106 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 101510004107 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510004108 acyl-activating enzyme (AAE) consensus motif; other site 101510004109 AMP binding site [chemical binding]; other site 101510004110 active site 101510004111 CoA binding site [chemical binding]; other site 101510004112 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510004113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004114 putative substrate translocation pore; other site 101510004115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004116 putative substrate translocation pore; other site 101510004117 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510004118 MarR family; Region: MarR; pfam01047 101510004119 enoyl-CoA hydratase; Provisional; Region: PRK05862 101510004120 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510004121 substrate binding site [chemical binding]; other site 101510004122 oxyanion hole (OAH) forming residues; other site 101510004123 trimer interface [polypeptide binding]; other site 101510004124 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510004125 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 101510004126 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 101510004127 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510004128 substrate binding site [chemical binding]; other site 101510004129 oxyanion hole (OAH) forming residues; other site 101510004130 trimer interface [polypeptide binding]; other site 101510004131 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 101510004132 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510004133 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 101510004134 substrate binding pocket [chemical binding]; other site 101510004135 FAD binding site [chemical binding]; other site 101510004136 catalytic base [active] 101510004137 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 101510004138 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 101510004139 tetrameric interface [polypeptide binding]; other site 101510004140 NAD binding site [chemical binding]; other site 101510004141 catalytic residues [active] 101510004142 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 101510004143 CutC family; Region: CutC; cl01218 101510004144 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 101510004145 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 101510004146 active site 101510004147 trimer interface [polypeptide binding]; other site 101510004148 allosteric site; other site 101510004149 active site lid [active] 101510004150 hexamer (dimer of trimers) interface [polypeptide binding]; other site 101510004151 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510004152 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 101510004153 active site 101510004154 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 101510004155 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 101510004156 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 101510004157 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 101510004158 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 101510004159 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 101510004160 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 101510004161 active site turn [active] 101510004162 phosphorylation site [posttranslational modification] 101510004163 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 101510004164 HPr interaction site; other site 101510004165 glycerol kinase (GK) interaction site [polypeptide binding]; other site 101510004166 active site 101510004167 phosphorylation site [posttranslational modification] 101510004168 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510004169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510004170 DNA-binding site [nucleotide binding]; DNA binding site 101510004171 UTRA domain; Region: UTRA; pfam07702 101510004172 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 101510004173 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510004174 FAD binding domain; Region: FAD_binding_4; pfam01565 101510004175 Berberine and berberine like; Region: BBE; pfam08031 101510004176 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 101510004177 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 101510004178 AAA ATPase domain; Region: AAA_16; pfam13191 101510004179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 101510004180 binding surface 101510004181 TPR motif; other site 101510004182 Uncharacterized conserved protein [Function unknown]; Region: COG4279 101510004183 SWIM zinc finger; Region: SWIM; pfam04434 101510004184 SNF2 Helicase protein; Region: DUF3670; pfam12419 101510004185 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 101510004186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510004187 ATP binding site [chemical binding]; other site 101510004188 putative Mg++ binding site [ion binding]; other site 101510004189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510004190 nucleotide binding region [chemical binding]; other site 101510004191 ATP-binding site [chemical binding]; other site 101510004192 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510004193 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 101510004194 putative NAD(P) binding site [chemical binding]; other site 101510004195 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 101510004196 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 101510004197 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 101510004198 Moco binding site; other site 101510004199 metal coordination site [ion binding]; other site 101510004200 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 101510004201 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 101510004202 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 101510004203 shikimate binding site; other site 101510004204 NAD(P) binding site [chemical binding]; other site 101510004205 OHCU decarboxylase; Region: UraD_2; TIGR03180 101510004206 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 101510004207 active site 101510004208 homotetramer interface [polypeptide binding]; other site 101510004209 urate oxidase; Region: urate_oxi; TIGR03383 101510004210 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 101510004211 active site 101510004212 xanthine permease; Region: pbuX; TIGR03173 101510004213 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 101510004214 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 101510004215 putative ADP-ribose binding site [chemical binding]; other site 101510004216 putative active site [active] 101510004217 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 101510004218 benzoate transporter; Region: benE; TIGR00843 101510004219 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 101510004220 active site 101510004221 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510004222 Phosphotransferase enzyme family; Region: APH; pfam01636 101510004223 putative active site [active] 101510004224 putative substrate binding site [chemical binding]; other site 101510004225 ATP binding site [chemical binding]; other site 101510004226 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 101510004227 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 101510004228 TPP-binding site [chemical binding]; other site 101510004229 heterodimer interface [polypeptide binding]; other site 101510004230 tetramer interface [polypeptide binding]; other site 101510004231 phosphorylation loop region [posttranslational modification] 101510004232 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 101510004233 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 101510004234 alpha subunit interface [polypeptide binding]; other site 101510004235 TPP binding site [chemical binding]; other site 101510004236 heterodimer interface [polypeptide binding]; other site 101510004237 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510004238 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 101510004239 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 101510004240 E3 interaction surface; other site 101510004241 lipoyl attachment site [posttranslational modification]; other site 101510004242 e3 binding domain; Region: E3_binding; pfam02817 101510004243 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 101510004244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 101510004246 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 101510004247 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 101510004248 Multicopper oxidase; Region: Cu-oxidase; pfam00394 101510004249 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 101510004250 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 101510004251 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 101510004252 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 101510004253 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 101510004254 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 101510004255 ligand binding site [chemical binding]; other site 101510004256 homodimer interface [polypeptide binding]; other site 101510004257 NAD(P) binding site [chemical binding]; other site 101510004258 trimer interface B [polypeptide binding]; other site 101510004259 trimer interface A [polypeptide binding]; other site 101510004260 Protein of unknown function, DUF488; Region: DUF488; cl01246 101510004261 acyl-CoA synthetase; Provisional; Region: PRK13391 101510004262 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510004263 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510004264 acyl-activating enzyme (AAE) consensus motif; other site 101510004265 acyl-activating enzyme (AAE) consensus motif; other site 101510004266 putative AMP binding site [chemical binding]; other site 101510004267 putative active site [active] 101510004268 putative CoA binding site [chemical binding]; other site 101510004269 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510004270 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510004271 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 101510004272 catalytic triad [active] 101510004273 active site nucleophile [active] 101510004274 FAD binding domain; Region: FAD_binding_4; pfam01565 101510004275 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 101510004276 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510004277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510004278 Coenzyme A binding pocket [chemical binding]; other site 101510004279 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 101510004280 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 101510004281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004282 H+ Antiporter protein; Region: 2A0121; TIGR00900 101510004283 putative substrate translocation pore; other site 101510004284 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 101510004285 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510004286 substrate binding pocket [chemical binding]; other site 101510004287 catalytic triad [active] 101510004288 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 101510004289 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 101510004290 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 101510004291 NMT1/THI5 like; Region: NMT1; pfam09084 101510004292 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510004293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510004294 dimer interface [polypeptide binding]; other site 101510004295 conserved gate region; other site 101510004296 putative PBP binding loops; other site 101510004297 ABC-ATPase subunit interface; other site 101510004298 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510004299 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 101510004300 Walker A/P-loop; other site 101510004301 ATP binding site [chemical binding]; other site 101510004302 Q-loop/lid; other site 101510004303 ABC transporter signature motif; other site 101510004304 Walker B; other site 101510004305 D-loop; other site 101510004306 H-loop/switch region; other site 101510004307 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510004308 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510004309 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510004310 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510004311 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 101510004312 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 101510004313 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 101510004314 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 101510004315 EspG family; Region: ESX-1_EspG; pfam14011 101510004316 Homeodomain-like domain; Region: HTH_23; pfam13384 101510004317 Winged helix-turn helix; Region: HTH_29; pfam13551 101510004318 Homeodomain-like domain; Region: HTH_32; pfam13565 101510004319 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510004320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510004321 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 101510004322 oxalacetate binding site [chemical binding]; other site 101510004323 citrylCoA binding site [chemical binding]; other site 101510004324 coenzyme A binding site [chemical binding]; other site 101510004325 catalytic triad [active] 101510004326 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 101510004327 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 101510004328 PQQ-like domain; Region: PQQ_2; pfam13360 101510004329 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 101510004330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510004331 S-adenosylmethionine binding site [chemical binding]; other site 101510004332 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 101510004333 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510004334 NAD(P) binding site [chemical binding]; other site 101510004335 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 101510004336 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510004337 acyl-activating enzyme (AAE) consensus motif; other site 101510004338 AMP binding site [chemical binding]; other site 101510004339 active site 101510004340 CoA binding site [chemical binding]; other site 101510004341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004342 putative substrate translocation pore; other site 101510004343 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510004344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510004345 NAD(P) binding site [chemical binding]; other site 101510004346 active site 101510004347 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510004348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510004349 active site 101510004350 putative acyltransferase; Provisional; Region: PRK05790 101510004351 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510004352 dimer interface [polypeptide binding]; other site 101510004353 active site 101510004354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510004355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510004356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510004357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510004358 Predicted transcriptional regulators [Transcription]; Region: COG1733 101510004359 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 101510004360 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510004361 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 101510004362 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 101510004363 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 101510004364 NAD binding site [chemical binding]; other site 101510004365 Phe binding site; other site 101510004366 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 101510004367 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 101510004368 dimer interface [polypeptide binding]; other site 101510004369 PYR/PP interface [polypeptide binding]; other site 101510004370 TPP binding site [chemical binding]; other site 101510004371 substrate binding site [chemical binding]; other site 101510004372 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 101510004373 TPP-binding site [chemical binding]; other site 101510004374 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 101510004375 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 101510004376 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 101510004377 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 101510004378 putative DNA binding site [nucleotide binding]; other site 101510004379 putative Zn2+ binding site [ion binding]; other site 101510004380 AsnC family; Region: AsnC_trans_reg; pfam01037 101510004381 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 101510004382 active site 101510004383 homopentamer interface [polypeptide binding]; other site 101510004384 dimer interface [polypeptide binding]; other site 101510004385 Restriction endonuclease; Region: Mrr_cat; pfam04471 101510004386 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 101510004387 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510004388 putative NAD(P) binding site [chemical binding]; other site 101510004389 catalytic Zn binding site [ion binding]; other site 101510004390 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 101510004391 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510004392 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510004393 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 101510004394 SnoaL-like domain; Region: SnoaL_3; pfam13474 101510004395 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510004396 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 101510004397 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 101510004398 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 101510004399 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 101510004400 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 101510004401 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 101510004402 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510004403 FAD binding domain; Region: FAD_binding_4; pfam01565 101510004404 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 101510004405 Domain of unknown function (DUF427); Region: DUF427; pfam04248 101510004406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 101510004407 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510004408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510004409 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 101510004410 Probable transposase; Region: OrfB_IS605; pfam01385 101510004411 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 101510004412 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 101510004413 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 101510004414 active site 101510004415 DNA binding site [nucleotide binding] 101510004416 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 101510004417 DNA binding site [nucleotide binding] 101510004418 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 101510004419 putative dimer interface [polypeptide binding]; other site 101510004420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510004421 short chain dehydrogenase; Provisional; Region: PRK06123 101510004422 classical (c) SDRs; Region: SDR_c; cd05233 101510004423 NAD(P) binding site [chemical binding]; other site 101510004424 active site 101510004425 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 101510004426 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 101510004427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510004428 ATP binding site [chemical binding]; other site 101510004429 putative Mg++ binding site [ion binding]; other site 101510004430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510004431 nucleotide binding region [chemical binding]; other site 101510004432 ATP-binding site [chemical binding]; other site 101510004433 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510004434 hypothetical protein; Provisional; Region: PRK14059 101510004435 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 101510004436 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 101510004437 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 101510004438 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 101510004439 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 101510004440 DNA binding residues [nucleotide binding] 101510004441 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 101510004442 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 101510004443 active site 101510004444 metal binding site [ion binding]; metal-binding site 101510004445 hexamer interface [polypeptide binding]; other site 101510004446 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 101510004447 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 101510004448 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 101510004449 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 101510004450 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 101510004451 TM2 domain; Region: TM2; cl00984 101510004452 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510004453 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510004454 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510004455 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 101510004456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 101510004457 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 101510004458 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510004459 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 101510004460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510004461 DNA binding residues [nucleotide binding] 101510004462 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510004463 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510004464 Magnesium ion binding site [ion binding]; other site 101510004465 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 101510004466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510004467 ATP binding site [chemical binding]; other site 101510004468 putative Mg++ binding site [ion binding]; other site 101510004469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510004470 nucleotide binding region [chemical binding]; other site 101510004471 Part of AAA domain; Region: AAA_19; pfam13245 101510004472 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 101510004473 AAA domain; Region: AAA_12; pfam13087 101510004474 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 101510004475 putative active site [active] 101510004476 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 101510004477 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510004478 putative metal binding site [ion binding]; other site 101510004479 Uncharacterized conserved protein [Function unknown]; Region: COG1479 101510004480 Protein of unknown function DUF262; Region: DUF262; pfam03235 101510004481 Uncharacterized conserved protein [Function unknown]; Region: COG3472 101510004482 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 101510004483 GIY-YIG motif/motif A; other site 101510004484 active site 101510004485 catalytic site [active] 101510004486 metal binding site [ion binding]; metal-binding site 101510004487 Tubulin like; Region: Tubulin_2; pfam13809 101510004488 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 101510004489 metal ion-dependent adhesion site (MIDAS); other site 101510004490 Nuclease-related domain; Region: NERD; pfam08378 101510004491 Part of AAA domain; Region: AAA_19; pfam13245 101510004492 Family description; Region: UvrD_C_2; pfam13538 101510004493 CoA binding domain; Region: CoA_binding_2; pfam13380 101510004494 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 101510004495 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510004496 putative metal binding site [ion binding]; other site 101510004497 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 101510004498 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 101510004499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510004500 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 101510004501 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510004502 DNA polymerase IV; Validated; Region: PRK03352 101510004503 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 101510004504 active site 101510004505 DNA binding site [nucleotide binding] 101510004506 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 101510004507 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510004508 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510004509 active site 101510004510 ATP binding site [chemical binding]; other site 101510004511 substrate binding site [chemical binding]; other site 101510004512 activation loop (A-loop); other site 101510004513 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 101510004514 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510004515 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510004516 Predicted acetyltransferase [General function prediction only]; Region: COG2388 101510004517 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 101510004518 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 101510004519 Thioredoxin; Region: Thioredoxin_4; pfam13462 101510004520 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 101510004521 putative hydrophobic ligand binding site [chemical binding]; other site 101510004522 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 101510004523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510004524 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 101510004525 active site 101510004526 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510004527 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510004528 active site 2 [active] 101510004529 active site 1 [active] 101510004530 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 101510004531 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 101510004532 putative di-iron ligands [ion binding]; other site 101510004533 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 101510004534 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 101510004535 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 101510004536 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510004537 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510004538 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510004539 NAD(P) binding site [chemical binding]; other site 101510004540 catalytic residues [active] 101510004541 choline dehydrogenase; Validated; Region: PRK02106 101510004542 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510004543 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510004544 NlpC/P60 family; Region: NLPC_P60; pfam00877 101510004545 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 101510004546 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510004547 NMT1/THI5 like; Region: NMT1; pfam09084 101510004548 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 101510004549 substrate binding pocket [chemical binding]; other site 101510004550 membrane-bound complex binding site; other site 101510004551 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 101510004552 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 101510004553 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 101510004554 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 101510004555 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510004556 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510004557 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510004558 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510004559 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510004560 active site 101510004561 non-prolyl cis peptide bond; other site 101510004562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510004563 active site 101510004564 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510004565 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 101510004566 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510004567 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 101510004568 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 101510004569 Walker A/P-loop; other site 101510004570 ATP binding site [chemical binding]; other site 101510004571 Q-loop/lid; other site 101510004572 ABC transporter signature motif; other site 101510004573 Walker B; other site 101510004574 D-loop; other site 101510004575 H-loop/switch region; other site 101510004576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510004577 dimer interface [polypeptide binding]; other site 101510004578 conserved gate region; other site 101510004579 ABC-ATPase subunit interface; other site 101510004580 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 101510004581 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510004582 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510004583 active site 101510004584 non-prolyl cis peptide bond; other site 101510004585 Predicted transcriptional regulators [Transcription]; Region: COG1733 101510004586 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 101510004587 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510004588 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 101510004589 putative NAD(P) binding site [chemical binding]; other site 101510004590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510004591 S-adenosylmethionine binding site [chemical binding]; other site 101510004592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510004593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510004594 non-specific DNA binding site [nucleotide binding]; other site 101510004595 salt bridge; other site 101510004596 sequence-specific DNA binding site [nucleotide binding]; other site 101510004597 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 101510004598 active site 101510004599 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 101510004600 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 101510004601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510004602 Coenzyme A binding pocket [chemical binding]; other site 101510004603 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510004604 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 101510004605 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 101510004606 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 101510004607 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 101510004608 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 101510004609 Walker A/P-loop; other site 101510004610 ATP binding site [chemical binding]; other site 101510004611 Q-loop/lid; other site 101510004612 ABC transporter signature motif; other site 101510004613 Walker B; other site 101510004614 D-loop; other site 101510004615 H-loop/switch region; other site 101510004616 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 101510004617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510004618 dimer interface [polypeptide binding]; other site 101510004619 conserved gate region; other site 101510004620 ABC-ATPase subunit interface; other site 101510004621 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 101510004622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510004623 Walker A/P-loop; other site 101510004624 ATP binding site [chemical binding]; other site 101510004625 Q-loop/lid; other site 101510004626 ABC transporter signature motif; other site 101510004627 Walker B; other site 101510004628 D-loop; other site 101510004629 H-loop/switch region; other site 101510004630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510004631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510004632 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 101510004633 Walker A/P-loop; other site 101510004634 ATP binding site [chemical binding]; other site 101510004635 Q-loop/lid; other site 101510004636 ABC transporter signature motif; other site 101510004637 Walker B; other site 101510004638 D-loop; other site 101510004639 H-loop/switch region; other site 101510004640 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510004641 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 101510004642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510004643 dimer interface [polypeptide binding]; other site 101510004644 conserved gate region; other site 101510004645 putative PBP binding loops; other site 101510004646 ABC-ATPase subunit interface; other site 101510004647 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 101510004648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510004649 dimer interface [polypeptide binding]; other site 101510004650 conserved gate region; other site 101510004651 putative PBP binding loops; other site 101510004652 ABC-ATPase subunit interface; other site 101510004653 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 101510004654 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 101510004655 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510004656 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510004657 active site 101510004658 non-prolyl cis peptide bond; other site 101510004659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510004660 DNA-binding site [nucleotide binding]; DNA binding site 101510004661 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510004662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510004663 catalytic residue [active] 101510004664 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510004665 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510004666 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510004667 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 101510004668 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 101510004669 homodimer interface [polypeptide binding]; other site 101510004670 substrate-cofactor binding pocket; other site 101510004671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510004672 catalytic residue [active] 101510004673 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 101510004674 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 101510004675 active site 101510004676 dimer interface [polypeptide binding]; other site 101510004677 non-prolyl cis peptide bond; other site 101510004678 insertion regions; other site 101510004679 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 101510004680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510004681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510004682 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510004683 NAD(P) binding site [chemical binding]; other site 101510004684 active site 101510004685 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 101510004686 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510004687 NAD binding site [chemical binding]; other site 101510004688 catalytic residues [active] 101510004689 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 101510004690 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 101510004691 tellurite resistance protein terB; Region: terB; cd07176 101510004692 putative metal binding site [ion binding]; other site 101510004693 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510004694 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510004695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510004696 active site 101510004697 metal binding site [ion binding]; metal-binding site 101510004698 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 101510004699 amidohydrolase; Region: amidohydrolases; TIGR01891 101510004700 metal binding site [ion binding]; metal-binding site 101510004701 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 101510004702 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 101510004703 homotrimer interaction site [polypeptide binding]; other site 101510004704 putative active site [active] 101510004705 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 101510004706 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 101510004707 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510004708 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 101510004709 hypothetical protein; Provisional; Region: PRK01346 101510004710 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 101510004711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510004712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510004713 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 101510004714 putative substrate binding pocket [chemical binding]; other site 101510004715 dimerization interface [polypeptide binding]; other site 101510004716 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510004717 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 101510004718 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 101510004719 FMN binding site [chemical binding]; other site 101510004720 active site 101510004721 homodimer interface [polypeptide binding]; other site 101510004722 putative catalytic residue [active] 101510004723 4Fe-4S cluster binding site [ion binding]; other site 101510004724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510004725 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 101510004726 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510004727 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 101510004728 NAD(P) binding site [chemical binding]; other site 101510004729 catalytic residues [active] 101510004730 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 101510004731 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 101510004732 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 101510004733 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 101510004734 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 101510004735 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 101510004736 Domain of unknown function (DUF385); Region: DUF385; pfam04075 101510004737 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 101510004738 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 101510004739 active site 101510004740 dimer interface [polypeptide binding]; other site 101510004741 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 101510004742 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 101510004743 active site 101510004744 FMN binding site [chemical binding]; other site 101510004745 substrate binding site [chemical binding]; other site 101510004746 3Fe-4S cluster binding site [ion binding]; other site 101510004747 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 101510004748 domain_subunit interface; other site 101510004749 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 101510004750 Flavodoxin; Region: Flavodoxin_1; pfam00258 101510004751 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 101510004752 FAD binding pocket [chemical binding]; other site 101510004753 FAD binding motif [chemical binding]; other site 101510004754 catalytic residues [active] 101510004755 NAD binding pocket [chemical binding]; other site 101510004756 phosphate binding motif [ion binding]; other site 101510004757 beta-alpha-beta structure motif; other site 101510004758 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 101510004759 PaaX-like protein; Region: PaaX; pfam07848 101510004760 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 101510004761 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 101510004762 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510004763 kynureninase; Region: kynureninase; TIGR01814 101510004764 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510004765 catalytic residue [active] 101510004766 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 101510004767 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 101510004768 NADP binding site [chemical binding]; other site 101510004769 active site 101510004770 regulatory binding site [polypeptide binding]; other site 101510004771 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 101510004772 RibD C-terminal domain; Region: RibD_C; cl17279 101510004773 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 101510004774 choline dehydrogenase; Validated; Region: PRK02106 101510004775 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510004776 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 101510004777 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 101510004778 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510004779 tetramerization interface [polypeptide binding]; other site 101510004780 NAD(P) binding site [chemical binding]; other site 101510004781 catalytic residues [active] 101510004782 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510004783 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 101510004784 [2Fe-2S] cluster binding site [ion binding]; other site 101510004785 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510004786 hydrophobic ligand binding site; other site 101510004787 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510004788 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510004789 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510004790 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 101510004791 [2Fe-2S] cluster binding site [ion binding]; other site 101510004792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 101510004793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510004794 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510004795 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510004796 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510004797 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 101510004798 hydroxyglutarate oxidase; Provisional; Region: PRK11728 101510004799 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 101510004800 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 101510004801 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 101510004802 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 101510004803 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 101510004804 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 101510004805 homodimer interface [polypeptide binding]; other site 101510004806 NADP binding site [chemical binding]; other site 101510004807 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 101510004808 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 101510004809 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 101510004810 putative active site [active] 101510004811 putative substrate binding site [chemical binding]; other site 101510004812 putative cosubstrate binding site; other site 101510004813 catalytic site [active] 101510004814 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510004815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 101510004816 FCD domain; Region: FCD; pfam07729 101510004817 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 101510004818 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 101510004819 dimer interface [polypeptide binding]; other site 101510004820 active site 101510004821 glycine-pyridoxal phosphate binding site [chemical binding]; other site 101510004822 folate binding site [chemical binding]; other site 101510004823 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 101510004824 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510004825 hydroxyglutarate oxidase; Provisional; Region: PRK11728 101510004826 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 101510004827 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 101510004828 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 101510004829 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 101510004830 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 101510004831 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 101510004832 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 101510004833 dihydropteroate synthase; Region: DHPS; TIGR01496 101510004834 substrate binding pocket [chemical binding]; other site 101510004835 dimer interface [polypeptide binding]; other site 101510004836 inhibitor binding site; inhibition site 101510004837 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 101510004838 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 101510004839 substrate-cofactor binding pocket; other site 101510004840 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 101510004841 lipoyl attachment site [posttranslational modification]; other site 101510004842 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 101510004843 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 101510004844 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 101510004845 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 101510004846 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 101510004847 active site 101510004848 catalytic site [active] 101510004849 substrate binding site [chemical binding]; other site 101510004850 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 101510004851 Dimer interface [polypeptide binding]; other site 101510004852 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 101510004853 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510004854 putative metal binding site [ion binding]; other site 101510004855 Excalibur calcium-binding domain; Region: Excalibur; smart00894 101510004856 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 101510004857 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 101510004858 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 101510004859 Predicted membrane protein [Function unknown]; Region: COG4270 101510004860 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 101510004861 AAA domain; Region: AAA_30; pfam13604 101510004862 Family description; Region: UvrD_C_2; pfam13538 101510004863 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 101510004864 Part of AAA domain; Region: AAA_19; pfam13245 101510004865 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 101510004866 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 101510004867 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 101510004868 GIY-YIG motif/motif A; other site 101510004869 putative active site [active] 101510004870 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 101510004871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510004872 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 101510004873 dihydroxyacetone kinase; Provisional; Region: PRK14479 101510004874 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 101510004875 DAK2 domain; Region: Dak2; pfam02734 101510004876 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 101510004877 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510004878 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510004879 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510004880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004881 putative substrate translocation pore; other site 101510004882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510004883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510004884 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 101510004885 putative substrate binding pocket [chemical binding]; other site 101510004886 dimerization interface [polypeptide binding]; other site 101510004887 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 101510004888 hypothetical protein; Provisional; Region: PRK12839 101510004889 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510004890 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510004891 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510004892 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510004893 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510004894 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510004895 active site 101510004896 catalytic tetrad [active] 101510004897 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510004898 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 101510004899 active site 101510004900 FMN binding site [chemical binding]; other site 101510004901 substrate binding site [chemical binding]; other site 101510004902 putative catalytic residue [active] 101510004903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510004904 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 101510004905 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 101510004906 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 101510004907 shikimate binding site; other site 101510004908 NAD(P) binding site [chemical binding]; other site 101510004909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004910 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510004911 putative substrate translocation pore; other site 101510004912 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 101510004913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510004914 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510004915 dimerization interface [polypeptide binding]; other site 101510004916 substrate binding pocket [chemical binding]; other site 101510004917 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510004918 classical (c) SDRs; Region: SDR_c; cd05233 101510004919 NAD(P) binding site [chemical binding]; other site 101510004920 active site 101510004921 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 101510004922 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 101510004923 active site 101510004924 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 101510004925 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 101510004926 active site 101510004927 dimer interface [polypeptide binding]; other site 101510004928 metal binding site [ion binding]; metal-binding site 101510004929 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 101510004930 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 101510004931 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510004932 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510004933 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510004934 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510004935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004936 benzoate transport; Region: 2A0115; TIGR00895 101510004937 putative substrate translocation pore; other site 101510004938 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510004939 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510004940 catalytic site [active] 101510004941 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 101510004942 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510004943 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510004944 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510004945 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 101510004946 Cupin domain; Region: Cupin_2; pfam07883 101510004947 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510004948 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 101510004949 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510004950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510004951 putative substrate translocation pore; other site 101510004952 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510004953 salicylate hydroxylase; Provisional; Region: PRK08163 101510004954 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 101510004955 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 101510004956 oligomer interface [polypeptide binding]; other site 101510004957 metal binding site [ion binding]; metal-binding site 101510004958 metal binding site [ion binding]; metal-binding site 101510004959 putative Cl binding site [ion binding]; other site 101510004960 aspartate ring; other site 101510004961 basic sphincter; other site 101510004962 hydrophobic gate; other site 101510004963 periplasmic entrance; other site 101510004964 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 101510004965 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 101510004966 active site 101510004967 FMN binding site [chemical binding]; other site 101510004968 substrate binding site [chemical binding]; other site 101510004969 3Fe-4S cluster binding site [ion binding]; other site 101510004970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510004971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510004972 Patatin-like phospholipase; Region: Patatin; pfam01734 101510004973 active site 101510004974 nucleophile elbow; other site 101510004975 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510004976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510004977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510004978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510004979 active site 101510004980 putative acyltransferase; Provisional; Region: PRK05790 101510004981 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510004982 dimer interface [polypeptide binding]; other site 101510004983 active site 101510004984 choline dehydrogenase; Validated; Region: PRK02106 101510004985 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510004986 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 101510004987 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 101510004988 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510004989 tetramerization interface [polypeptide binding]; other site 101510004990 NAD(P) binding site [chemical binding]; other site 101510004991 catalytic residues [active] 101510004992 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510004993 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510004994 active site 101510004995 catalytic tetrad [active] 101510004996 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 101510004997 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 101510004998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510004999 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510005000 NAD(P) binding site [chemical binding]; other site 101510005001 active site 101510005002 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510005003 classical (c) SDRs; Region: SDR_c; cd05233 101510005004 NAD(P) binding site [chemical binding]; other site 101510005005 active site 101510005006 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 101510005007 classical (c) SDRs; Region: SDR_c; cd05233 101510005008 NAD(P) binding site [chemical binding]; other site 101510005009 active site 101510005010 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510005011 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510005012 Domain of unknown function (DUF222); Region: DUF222; pfam02720 101510005013 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510005014 active site 101510005015 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 101510005016 HipA N-terminal domain; Region: Couple_hipA; pfam13657 101510005017 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 101510005018 HipA-like N-terminal domain; Region: HipA_N; pfam07805 101510005019 HipA-like C-terminal domain; Region: HipA_C; pfam07804 101510005020 endonuclease IV; Provisional; Region: PRK01060 101510005021 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 101510005022 AP (apurinic/apyrimidinic) site pocket; other site 101510005023 DNA interaction; other site 101510005024 Metal-binding active site; metal-binding site 101510005025 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 101510005026 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 101510005027 Sulfate transporter family; Region: Sulfate_transp; pfam00916 101510005028 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 101510005029 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510005030 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510005031 substrate binding pocket [chemical binding]; other site 101510005032 membrane-bound complex binding site; other site 101510005033 hinge residues; other site 101510005034 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 101510005035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510005036 dimer interface [polypeptide binding]; other site 101510005037 conserved gate region; other site 101510005038 putative PBP binding loops; other site 101510005039 ABC-ATPase subunit interface; other site 101510005040 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510005041 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510005042 Walker A/P-loop; other site 101510005043 ATP binding site [chemical binding]; other site 101510005044 Q-loop/lid; other site 101510005045 ABC transporter signature motif; other site 101510005046 Walker B; other site 101510005047 D-loop; other site 101510005048 H-loop/switch region; other site 101510005049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510005050 Coenzyme A binding pocket [chemical binding]; other site 101510005051 Secretory lipase; Region: LIP; pfam03583 101510005052 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 101510005053 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 101510005054 active site 101510005055 nucleophile elbow; other site 101510005056 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 101510005057 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 101510005058 acyl-activating enzyme (AAE) consensus motif; other site 101510005059 putative AMP binding site [chemical binding]; other site 101510005060 putative active site [active] 101510005061 putative CoA binding site [chemical binding]; other site 101510005062 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510005063 MarR family; Region: MarR_2; pfam12802 101510005064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 101510005065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510005066 Coenzyme A binding pocket [chemical binding]; other site 101510005067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 101510005068 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 101510005069 putative hydrophobic ligand binding site [chemical binding]; other site 101510005070 MoxR-like ATPases [General function prediction only]; Region: COG0714 101510005071 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 101510005072 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 101510005073 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 101510005074 metal ion-dependent adhesion site (MIDAS); other site 101510005075 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 101510005076 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510005077 active site 101510005078 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 101510005079 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510005080 active site 101510005081 Asp23 family; Region: Asp23; pfam03780 101510005082 Asp23 family; Region: Asp23; cl00574 101510005083 Asp23 family; Region: Asp23; pfam03780 101510005084 YCII-related domain; Region: YCII; cl00999 101510005085 elongation factor Tu; Reviewed; Region: PRK00049 101510005086 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 101510005087 G1 box; other site 101510005088 GEF interaction site [polypeptide binding]; other site 101510005089 GTP/Mg2+ binding site [chemical binding]; other site 101510005090 Switch I region; other site 101510005091 G2 box; other site 101510005092 G3 box; other site 101510005093 Switch II region; other site 101510005094 G4 box; other site 101510005095 G5 box; other site 101510005096 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 101510005097 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 101510005098 Antibiotic Binding Site [chemical binding]; other site 101510005099 elongation factor G; Reviewed; Region: PRK00007 101510005100 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 101510005101 G1 box; other site 101510005102 putative GEF interaction site [polypeptide binding]; other site 101510005103 GTP/Mg2+ binding site [chemical binding]; other site 101510005104 Switch I region; other site 101510005105 G2 box; other site 101510005106 G3 box; other site 101510005107 Switch II region; other site 101510005108 G4 box; other site 101510005109 G5 box; other site 101510005110 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 101510005111 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 101510005112 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 101510005113 30S ribosomal protein S7; Validated; Region: PRK05302 101510005114 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 101510005115 S17 interaction site [polypeptide binding]; other site 101510005116 S8 interaction site; other site 101510005117 16S rRNA interaction site [nucleotide binding]; other site 101510005118 streptomycin interaction site [chemical binding]; other site 101510005119 23S rRNA interaction site [nucleotide binding]; other site 101510005120 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 101510005121 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 101510005122 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 101510005123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510005124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510005125 enoyl-CoA hydratase; Provisional; Region: PRK07827 101510005126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510005127 substrate binding site [chemical binding]; other site 101510005128 oxyanion hole (OAH) forming residues; other site 101510005129 trimer interface [polypeptide binding]; other site 101510005130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510005131 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510005132 active site 101510005133 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 101510005134 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510005135 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510005136 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 101510005137 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510005138 carboxyltransferase (CT) interaction site; other site 101510005139 biotinylation site [posttranslational modification]; other site 101510005140 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 101510005141 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510005142 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510005143 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510005144 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510005145 active site 101510005146 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 101510005147 TIGR03084 family protein; Region: TIGR03084 101510005148 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510005149 Wyosine base formation; Region: Wyosine_form; pfam08608 101510005150 short chain dehydrogenase; Provisional; Region: PRK05866 101510005151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510005152 NAD(P) binding site [chemical binding]; other site 101510005153 active site 101510005154 enoyl-CoA hydratase; Provisional; Region: PRK09245 101510005155 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510005156 substrate binding site [chemical binding]; other site 101510005157 oxyanion hole (OAH) forming residues; other site 101510005158 trimer interface [polypeptide binding]; other site 101510005159 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 101510005160 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 101510005161 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 101510005162 Zn binding site [ion binding]; other site 101510005163 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510005164 hypothetical protein; Provisional; Region: PRK08244 101510005165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510005166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510005167 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510005168 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 101510005169 cyclase homology domain; Region: CHD; cd07302 101510005170 nucleotidyl binding site; other site 101510005171 metal binding site [ion binding]; metal-binding site 101510005172 dimer interface [polypeptide binding]; other site 101510005173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510005174 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510005175 CoenzymeA binding site [chemical binding]; other site 101510005176 subunit interaction site [polypeptide binding]; other site 101510005177 PHB binding site; other site 101510005178 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 101510005179 threonine dehydratase; Provisional; Region: PRK08246 101510005180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510005181 catalytic residue [active] 101510005182 Pirin-related protein [General function prediction only]; Region: COG1741 101510005183 Pirin; Region: Pirin; pfam02678 101510005184 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 101510005185 MarR family; Region: MarR; pfam01047 101510005186 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 101510005187 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510005188 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510005189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510005190 putative substrate translocation pore; other site 101510005191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510005192 MarR family; Region: MarR_2; pfam12802 101510005193 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 101510005194 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510005195 NAD(P) binding site [chemical binding]; other site 101510005196 Ferredoxin [Energy production and conversion]; Region: COG1146 101510005197 4Fe-4S binding domain; Region: Fer4; pfam00037 101510005198 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 101510005199 ferredoxin-NADP+ reductase; Region: PLN02852 101510005200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510005201 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 101510005202 active site 101510005203 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510005204 active site 2 [active] 101510005205 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510005206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510005207 salt bridge; other site 101510005208 non-specific DNA binding site [nucleotide binding]; other site 101510005209 sequence-specific DNA binding site [nucleotide binding]; other site 101510005210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510005211 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510005212 active site 101510005213 catalytic tetrad [active] 101510005214 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510005215 catalytic core [active] 101510005216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510005217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510005218 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510005219 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510005220 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 101510005221 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 101510005222 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 101510005223 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 101510005224 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 101510005225 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 101510005226 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 101510005227 G-loop; other site 101510005228 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 101510005229 DNA binding site [nucleotide binding] 101510005230 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 101510005231 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 101510005232 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 101510005233 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 101510005234 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 101510005235 RPB10 interaction site [polypeptide binding]; other site 101510005236 RPB1 interaction site [polypeptide binding]; other site 101510005237 RPB11 interaction site [polypeptide binding]; other site 101510005238 RPB3 interaction site [polypeptide binding]; other site 101510005239 RPB12 interaction site [polypeptide binding]; other site 101510005240 MMPL family; Region: MMPL; pfam03176 101510005241 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 101510005242 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510005243 mce related protein; Region: MCE; pfam02470 101510005244 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510005245 mce related protein; Region: MCE; pfam02470 101510005246 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510005247 mce related protein; Region: MCE; pfam02470 101510005248 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510005249 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510005250 mce related protein; Region: MCE; pfam02470 101510005251 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 101510005252 mce related protein; Region: MCE; pfam02470 101510005253 mce related protein; Region: MCE; pfam02470 101510005254 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510005255 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 101510005256 Permease; Region: Permease; pfam02405 101510005257 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 101510005258 Permease; Region: Permease; pfam02405 101510005259 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 101510005260 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 101510005261 Walker A/P-loop; other site 101510005262 ATP binding site [chemical binding]; other site 101510005263 Q-loop/lid; other site 101510005264 ABC transporter signature motif; other site 101510005265 Walker B; other site 101510005266 D-loop; other site 101510005267 H-loop/switch region; other site 101510005268 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 101510005269 core dimer interface [polypeptide binding]; other site 101510005270 peripheral dimer interface [polypeptide binding]; other site 101510005271 L10 interface [polypeptide binding]; other site 101510005272 L11 interface [polypeptide binding]; other site 101510005273 putative EF-Tu interaction site [polypeptide binding]; other site 101510005274 putative EF-G interaction site [polypeptide binding]; other site 101510005275 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 101510005276 23S rRNA interface [nucleotide binding]; other site 101510005277 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 101510005278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510005279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510005280 putative substrate translocation pore; other site 101510005281 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 101510005282 mRNA/rRNA interface [nucleotide binding]; other site 101510005283 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 101510005284 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 101510005285 23S rRNA interface [nucleotide binding]; other site 101510005286 L7/L12 interface [polypeptide binding]; other site 101510005287 putative thiostrepton binding site; other site 101510005288 L25 interface [polypeptide binding]; other site 101510005289 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 101510005290 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 101510005291 putative homodimer interface [polypeptide binding]; other site 101510005292 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 101510005293 heterodimer interface [polypeptide binding]; other site 101510005294 homodimer interface [polypeptide binding]; other site 101510005295 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 101510005296 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 101510005297 active site 101510005298 catalytic site [active] 101510005299 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 101510005300 active site 101510005301 catalytic site [active] 101510005302 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 101510005303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 101510005304 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 101510005305 heat shock protein HtpX; Provisional; Region: PRK03072 101510005306 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 101510005307 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 101510005308 substrate binding pocket [chemical binding]; other site 101510005309 chain length determination region; other site 101510005310 substrate-Mg2+ binding site; other site 101510005311 catalytic residues [active] 101510005312 aspartate-rich region 1; other site 101510005313 active site lid residues [active] 101510005314 aspartate-rich region 2; other site 101510005315 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 101510005316 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 101510005317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510005318 S-adenosylmethionine binding site [chemical binding]; other site 101510005319 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 101510005320 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 101510005321 NAD(P) binding site [chemical binding]; other site 101510005322 catalytic residues [active] 101510005323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510005324 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 101510005325 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 101510005326 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 101510005327 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 101510005328 dimer interface [polypeptide binding]; other site 101510005329 tetramer interface [polypeptide binding]; other site 101510005330 PYR/PP interface [polypeptide binding]; other site 101510005331 TPP binding site [chemical binding]; other site 101510005332 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 101510005333 TPP-binding site; other site 101510005334 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 101510005335 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 101510005336 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 101510005337 FAD binding pocket [chemical binding]; other site 101510005338 FAD binding motif [chemical binding]; other site 101510005339 phosphate binding motif [ion binding]; other site 101510005340 NAD binding pocket [chemical binding]; other site 101510005341 O-succinylbenzoate synthase; Provisional; Region: PRK02901 101510005342 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 101510005343 active site 101510005344 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510005345 CoenzymeA binding site [chemical binding]; other site 101510005346 subunit interaction site [polypeptide binding]; other site 101510005347 PHB binding site; other site 101510005348 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510005349 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 101510005350 substrate binding site [chemical binding]; other site 101510005351 oxyanion hole (OAH) forming residues; other site 101510005352 trimer interface [polypeptide binding]; other site 101510005353 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 101510005354 Sulfatase; Region: Sulfatase; pfam00884 101510005355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510005356 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510005357 active site 101510005358 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 101510005359 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 101510005360 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 101510005361 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 101510005362 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510005363 acyl-activating enzyme (AAE) consensus motif; other site 101510005364 AMP binding site [chemical binding]; other site 101510005365 active site 101510005366 CoA binding site [chemical binding]; other site 101510005367 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 101510005368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510005369 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 101510005370 Walker A/P-loop; other site 101510005371 ATP binding site [chemical binding]; other site 101510005372 Q-loop/lid; other site 101510005373 ABC transporter signature motif; other site 101510005374 Walker B; other site 101510005375 D-loop; other site 101510005376 H-loop/switch region; other site 101510005377 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 101510005378 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510005379 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510005380 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 101510005381 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 101510005382 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 101510005383 homotrimer interaction site [polypeptide binding]; other site 101510005384 putative active site [active] 101510005385 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 101510005386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510005387 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510005388 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510005389 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 101510005390 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510005391 Predicted ATPase [General function prediction only]; Region: COG3903 101510005392 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 101510005393 UbiA prenyltransferase family; Region: UbiA; pfam01040 101510005394 Membrane protein of unknown function; Region: DUF360; pfam04020 101510005395 Clp amino terminal domain; Region: Clp_N; pfam02861 101510005396 Clp amino terminal domain; Region: Clp_N; pfam02861 101510005397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 101510005398 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 101510005399 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 101510005400 putative acyl-acceptor binding pocket; other site 101510005401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 101510005402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510005403 Coenzyme A binding pocket [chemical binding]; other site 101510005404 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 101510005405 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 101510005406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510005407 catalytic residue [active] 101510005408 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 101510005409 DNA binding residues [nucleotide binding] 101510005410 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 101510005411 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 101510005412 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 101510005413 ResB-like family; Region: ResB; pfam05140 101510005414 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 101510005415 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 101510005416 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 101510005417 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 101510005418 catalytic residues [active] 101510005419 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510005420 catalytic core [active] 101510005421 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 101510005422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510005423 inhibitor-cofactor binding pocket; inhibition site 101510005424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510005425 catalytic residue [active] 101510005426 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 101510005427 dimer interface [polypeptide binding]; other site 101510005428 substrate binding site [chemical binding]; other site 101510005429 metal binding site [ion binding]; metal-binding site 101510005430 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510005431 classical (c) SDRs; Region: SDR_c; cd05233 101510005432 NAD(P) binding site [chemical binding]; other site 101510005433 active site 101510005434 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 101510005435 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 101510005436 dimer interface [polypeptide binding]; other site 101510005437 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 101510005438 active site 101510005439 Fe binding site [ion binding]; other site 101510005440 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 101510005441 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 101510005442 AsnC family; Region: AsnC_trans_reg; pfam01037 101510005443 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510005444 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 101510005445 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 101510005446 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510005447 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510005448 active site 101510005449 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 101510005450 dimer interface [polypeptide binding]; other site 101510005451 active site 101510005452 Schiff base residues; other site 101510005453 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 101510005454 homodimer interface [polypeptide binding]; other site 101510005455 active site 101510005456 SAM binding site [chemical binding]; other site 101510005457 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 101510005458 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 101510005459 active site 101510005460 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 101510005461 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 101510005462 domain interfaces; other site 101510005463 active site 101510005464 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 101510005465 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 101510005466 tRNA; other site 101510005467 putative tRNA binding site [nucleotide binding]; other site 101510005468 putative NADP binding site [chemical binding]; other site 101510005469 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 101510005470 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 101510005471 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 101510005472 CoA binding domain; Region: CoA_binding; pfam02629 101510005473 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 101510005474 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 101510005475 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 101510005476 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 101510005477 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 101510005478 putative acyl-acceptor binding pocket; other site 101510005479 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 101510005480 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 101510005481 putative NAD(P) binding site [chemical binding]; other site 101510005482 active site 101510005483 putative substrate binding site [chemical binding]; other site 101510005484 DNA binding domain, excisionase family; Region: excise; TIGR01764 101510005485 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 101510005486 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 101510005487 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 101510005488 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 101510005489 active site 2 [active] 101510005490 active site 1 [active] 101510005491 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 101510005492 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 101510005493 exopolyphosphatase; Region: exo_poly_only; TIGR03706 101510005494 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 101510005495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510005496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510005497 active site 101510005498 phosphorylation site [posttranslational modification] 101510005499 intermolecular recognition site; other site 101510005500 dimerization interface [polypeptide binding]; other site 101510005501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510005502 DNA binding site [nucleotide binding] 101510005503 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 101510005504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510005505 dimer interface [polypeptide binding]; other site 101510005506 phosphorylation site [posttranslational modification] 101510005507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510005508 ATP binding site [chemical binding]; other site 101510005509 Mg2+ binding site [ion binding]; other site 101510005510 G-X-G motif; other site 101510005511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510005512 catalytic core [active] 101510005513 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510005514 4-coumarate--CoA ligase; Region: PLN02246 101510005515 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 101510005516 acyl-activating enzyme (AAE) consensus motif; other site 101510005517 active site 101510005518 putative CoA binding site [chemical binding]; other site 101510005519 AMP binding site [chemical binding]; other site 101510005520 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 101510005521 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 101510005522 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 101510005523 putative ADP-binding pocket [chemical binding]; other site 101510005524 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510005525 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 101510005526 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 101510005527 Isochorismatase family; Region: Isochorismatase; pfam00857 101510005528 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 101510005529 catalytic triad [active] 101510005530 conserved cis-peptide bond; other site 101510005531 Protein of unknown function (DUF742); Region: DUF742; pfam05331 101510005532 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 101510005533 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510005534 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510005535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510005536 putative substrate translocation pore; other site 101510005537 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 101510005538 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 101510005539 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 101510005540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510005541 NAD(P) binding site [chemical binding]; other site 101510005542 active site 101510005543 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 101510005544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 101510005545 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 101510005546 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 101510005547 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 101510005548 FAD binding domain; Region: FAD_binding_4; pfam01565 101510005549 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 101510005550 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 101510005551 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 101510005552 TROVE domain; Region: TROVE; pfam05731 101510005553 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 101510005554 metal ion-dependent adhesion site (MIDAS); other site 101510005555 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 101510005556 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 101510005557 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 101510005558 intersubunit interface [polypeptide binding]; other site 101510005559 active site 101510005560 catalytic residue [active] 101510005561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510005562 S-adenosylmethionine binding site [chemical binding]; other site 101510005563 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 101510005564 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 101510005565 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 101510005566 putative active site [active] 101510005567 putative substrate binding site [chemical binding]; other site 101510005568 putative cosubstrate binding site; other site 101510005569 catalytic site [active] 101510005570 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510005571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510005572 DNA-binding site [nucleotide binding]; DNA binding site 101510005573 FCD domain; Region: FCD; pfam07729 101510005574 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510005575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510005576 D-galactonate transporter; Region: 2A0114; TIGR00893 101510005577 putative substrate translocation pore; other site 101510005578 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510005579 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 101510005580 putative active site [active] 101510005581 catalytic triad [active] 101510005582 putative dimer interface [polypeptide binding]; other site 101510005583 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510005584 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510005585 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510005586 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510005587 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 101510005588 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510005589 DNA binding residues [nucleotide binding] 101510005590 putative dimer interface [polypeptide binding]; other site 101510005591 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 101510005592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510005593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510005594 non-specific DNA binding site [nucleotide binding]; other site 101510005595 salt bridge; other site 101510005596 sequence-specific DNA binding site [nucleotide binding]; other site 101510005597 Predicted membrane protein [Function unknown]; Region: COG2733 101510005598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510005599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510005600 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510005601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510005602 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 101510005603 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 101510005604 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 101510005605 putative ADP-binding pocket [chemical binding]; other site 101510005606 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 101510005607 anti sigma factor interaction site; other site 101510005608 regulatory phosphorylation site [posttranslational modification]; other site 101510005609 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510005610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 101510005611 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 101510005612 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 101510005613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510005614 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 101510005615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510005616 DNA binding residues [nucleotide binding] 101510005617 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510005618 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 101510005619 putative NAD(P) binding site [chemical binding]; other site 101510005620 putative substrate binding site [chemical binding]; other site 101510005621 catalytic Zn binding site [ion binding]; other site 101510005622 structural Zn binding site [ion binding]; other site 101510005623 dimer interface [polypeptide binding]; other site 101510005624 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 101510005625 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 101510005626 THF binding site; other site 101510005627 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 101510005628 substrate binding site [chemical binding]; other site 101510005629 THF binding site; other site 101510005630 zinc-binding site [ion binding]; other site 101510005631 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 101510005632 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510005633 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510005634 isocitrate lyase; Provisional; Region: PRK15063 101510005635 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 101510005636 tetramer interface [polypeptide binding]; other site 101510005637 active site 101510005638 Mg2+/Mn2+ binding site [ion binding]; other site 101510005639 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 101510005640 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 101510005641 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510005642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510005643 non-specific DNA binding site [nucleotide binding]; other site 101510005644 salt bridge; other site 101510005645 sequence-specific DNA binding site [nucleotide binding]; other site 101510005646 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 101510005647 Domain of unknown function (DUF955); Region: DUF955; pfam06114 101510005648 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 101510005649 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 101510005650 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 101510005651 putative ligand binding site [chemical binding]; other site 101510005652 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 101510005653 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510005654 TM-ABC transporter signature motif; other site 101510005655 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510005656 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 101510005657 TM-ABC transporter signature motif; other site 101510005658 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 101510005659 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 101510005660 Walker A/P-loop; other site 101510005661 ATP binding site [chemical binding]; other site 101510005662 Q-loop/lid; other site 101510005663 ABC transporter signature motif; other site 101510005664 Walker B; other site 101510005665 D-loop; other site 101510005666 H-loop/switch region; other site 101510005667 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 101510005668 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 101510005669 Walker A/P-loop; other site 101510005670 ATP binding site [chemical binding]; other site 101510005671 Q-loop/lid; other site 101510005672 ABC transporter signature motif; other site 101510005673 Walker B; other site 101510005674 D-loop; other site 101510005675 H-loop/switch region; other site 101510005676 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510005677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510005678 DNA-binding site [nucleotide binding]; DNA binding site 101510005679 FCD domain; Region: FCD; pfam07729 101510005680 classical (c) SDRs; Region: SDR_c; cd05233 101510005681 NAD(P) binding site [chemical binding]; other site 101510005682 active site 101510005683 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510005684 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 101510005685 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 101510005686 urea carboxylase; Region: urea_carbox; TIGR02712 101510005687 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510005688 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510005689 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 101510005690 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 101510005691 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 101510005692 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510005693 carboxyltransferase (CT) interaction site; other site 101510005694 biotinylation site [posttranslational modification]; other site 101510005695 allophanate hydrolase; Provisional; Region: PRK08186 101510005696 Amidase; Region: Amidase; cl11426 101510005697 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 101510005698 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 101510005699 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 101510005700 NADP binding site [chemical binding]; other site 101510005701 Predicted transcriptional regulators [Transcription]; Region: COG1733 101510005702 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 101510005703 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 101510005704 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 101510005705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510005706 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 101510005707 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 101510005708 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510005709 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510005710 Putative esterase; Region: Esterase; pfam00756 101510005711 PspC domain; Region: PspC; pfam04024 101510005712 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 101510005713 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 101510005714 ring oligomerisation interface [polypeptide binding]; other site 101510005715 ATP/Mg binding site [chemical binding]; other site 101510005716 stacking interactions; other site 101510005717 hinge regions; other site 101510005718 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 101510005719 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 101510005720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510005721 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510005722 Ligand Binding Site [chemical binding]; other site 101510005723 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510005724 Ligand Binding Site [chemical binding]; other site 101510005725 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 101510005726 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 101510005727 putative NAD(P) binding site [chemical binding]; other site 101510005728 putative substrate binding site [chemical binding]; other site 101510005729 catalytic Zn binding site [ion binding]; other site 101510005730 structural Zn binding site [ion binding]; other site 101510005731 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510005732 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 101510005733 hydroxyglutarate oxidase; Provisional; Region: PRK11728 101510005734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510005735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510005736 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 101510005737 active sites [active] 101510005738 tetramer interface [polypeptide binding]; other site 101510005739 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510005740 hydrophobic ligand binding site; other site 101510005741 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510005742 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 101510005743 beta-clamp/clamp loader binding surface; other site 101510005744 beta-clamp/translesion DNA polymerase binding surface; other site 101510005745 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 101510005746 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 101510005747 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 101510005748 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 101510005749 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 101510005750 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 101510005751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510005752 Walker A motif; other site 101510005753 ATP binding site [chemical binding]; other site 101510005754 Walker B motif; other site 101510005755 arginine finger; other site 101510005756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510005757 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 101510005758 Walker A motif; other site 101510005759 ATP binding site [chemical binding]; other site 101510005760 Walker B motif; other site 101510005761 arginine finger; other site 101510005762 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 101510005763 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 101510005764 tetramer interface [polypeptide binding]; other site 101510005765 active site 101510005766 Mg2+/Mn2+ binding site [ion binding]; other site 101510005767 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 101510005768 nudix motif; other site 101510005769 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 101510005770 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 101510005771 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 101510005772 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 101510005773 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 101510005774 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 101510005775 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 101510005776 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 101510005777 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 101510005778 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 101510005779 active site 101510005780 carboxylate-amine ligase; Provisional; Region: PRK13517 101510005781 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 101510005782 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 101510005783 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 101510005784 E-class dimer interface [polypeptide binding]; other site 101510005785 P-class dimer interface [polypeptide binding]; other site 101510005786 active site 101510005787 Cu2+ binding site [ion binding]; other site 101510005788 Zn2+ binding site [ion binding]; other site 101510005789 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 101510005790 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 101510005791 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 101510005792 active site 101510005793 catalytic residues [active] 101510005794 metal binding site [ion binding]; metal-binding site 101510005795 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 101510005796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510005797 Coenzyme A binding pocket [chemical binding]; other site 101510005798 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 101510005799 putative catalytic site [active] 101510005800 putative phosphate binding site [ion binding]; other site 101510005801 active site 101510005802 metal binding site A [ion binding]; metal-binding site 101510005803 DNA binding site [nucleotide binding] 101510005804 putative AP binding site [nucleotide binding]; other site 101510005805 putative metal binding site B [ion binding]; other site 101510005806 Predicted acetyltransferase [General function prediction only]; Region: COG2388 101510005807 Predicted acetyltransferase [General function prediction only]; Region: COG2388 101510005808 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 101510005809 ThiC-associated domain; Region: ThiC-associated; pfam13667 101510005810 ThiC family; Region: ThiC; pfam01964 101510005811 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 101510005812 dimer interface [polypeptide binding]; other site 101510005813 substrate binding site [chemical binding]; other site 101510005814 ATP binding site [chemical binding]; other site 101510005815 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 101510005816 cyclase homology domain; Region: CHD; cd07302 101510005817 nucleotidyl binding site; other site 101510005818 metal binding site [ion binding]; metal-binding site 101510005819 dimer interface [polypeptide binding]; other site 101510005820 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 101510005821 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 101510005822 PA/protease or protease-like domain interface [polypeptide binding]; other site 101510005823 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 101510005824 Peptidase family M28; Region: Peptidase_M28; pfam04389 101510005825 active site 101510005826 metal binding site [ion binding]; metal-binding site 101510005827 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 101510005828 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 101510005829 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 101510005830 Walker A/P-loop; other site 101510005831 ATP binding site [chemical binding]; other site 101510005832 Q-loop/lid; other site 101510005833 ABC transporter signature motif; other site 101510005834 Walker B; other site 101510005835 D-loop; other site 101510005836 H-loop/switch region; other site 101510005837 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 101510005838 ThiS interaction site; other site 101510005839 putative active site [active] 101510005840 tetramer interface [polypeptide binding]; other site 101510005841 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 101510005842 thiS-thiF/thiG interaction site; other site 101510005843 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 101510005844 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 101510005845 thiamine phosphate binding site [chemical binding]; other site 101510005846 active site 101510005847 pyrophosphate binding site [ion binding]; other site 101510005848 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 101510005849 nudix motif; other site 101510005850 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510005851 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510005852 substrate binding pocket [chemical binding]; other site 101510005853 membrane-bound complex binding site; other site 101510005854 hinge residues; other site 101510005855 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510005856 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510005857 active site 101510005858 ATP binding site [chemical binding]; other site 101510005859 substrate binding site [chemical binding]; other site 101510005860 activation loop (A-loop); other site 101510005861 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 101510005862 propionate/acetate kinase; Provisional; Region: PRK12379 101510005863 phosphate acetyltransferase; Reviewed; Region: PRK05632 101510005864 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510005865 DRTGG domain; Region: DRTGG; pfam07085 101510005866 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 101510005867 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 101510005868 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 101510005869 trimer interface [polypeptide binding]; other site 101510005870 active site 101510005871 substrate binding site [chemical binding]; other site 101510005872 CoA binding site [chemical binding]; other site 101510005873 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 101510005874 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 101510005875 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510005876 Domain of unknown function (DUF202); Region: DUF202; cl09954 101510005877 Predicted esterase [General function prediction only]; Region: COG0627 101510005878 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510005879 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510005880 acyl-activating enzyme (AAE) consensus motif; other site 101510005881 AMP binding site [chemical binding]; other site 101510005882 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510005883 Condensation domain; Region: Condensation; pfam00668 101510005884 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510005885 Condensation domain; Region: Condensation; pfam00668 101510005886 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510005887 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510005888 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510005889 acyl-activating enzyme (AAE) consensus motif; other site 101510005890 AMP binding site [chemical binding]; other site 101510005891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510005892 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510005893 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510005894 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510005895 acyl-activating enzyme (AAE) consensus motif; other site 101510005896 AMP binding site [chemical binding]; other site 101510005897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510005898 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510005899 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 101510005900 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510005901 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 101510005902 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 101510005903 active site 101510005904 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510005905 Condensation domain; Region: Condensation; pfam00668 101510005906 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510005907 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510005908 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510005909 Condensation domain; Region: Condensation; pfam00668 101510005910 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510005911 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510005912 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510005913 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510005914 acyl-activating enzyme (AAE) consensus motif; other site 101510005915 AMP binding site [chemical binding]; other site 101510005916 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510005917 Condensation domain; Region: Condensation; pfam00668 101510005918 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510005919 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510005920 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510005921 acyl-activating enzyme (AAE) consensus motif; other site 101510005922 AMP binding site [chemical binding]; other site 101510005923 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510005924 Condensation domain; Region: Condensation; pfam00668 101510005925 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510005926 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510005927 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510005928 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510005929 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510005930 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510005931 acyl-activating enzyme (AAE) consensus motif; other site 101510005932 AMP binding site [chemical binding]; other site 101510005933 FkbH-like domain; Region: FkbH; TIGR01686 101510005934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510005935 active site 101510005936 motif I; other site 101510005937 motif II; other site 101510005938 hypothetical protein; Validated; Region: PRK06840 101510005939 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 101510005940 active site 101510005941 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510005942 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510005943 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510005944 active site 101510005945 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 101510005946 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510005947 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 101510005948 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510005949 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 101510005950 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510005951 active site 101510005952 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510005953 non-prolyl cis peptide bond; other site 101510005954 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510005955 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 101510005956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510005957 Walker A/P-loop; other site 101510005958 ATP binding site [chemical binding]; other site 101510005959 Q-loop/lid; other site 101510005960 ABC transporter signature motif; other site 101510005961 Walker B; other site 101510005962 D-loop; other site 101510005963 H-loop/switch region; other site 101510005964 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 101510005965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510005966 Walker A/P-loop; other site 101510005967 ATP binding site [chemical binding]; other site 101510005968 Q-loop/lid; other site 101510005969 ABC transporter signature motif; other site 101510005970 Walker B; other site 101510005971 D-loop; other site 101510005972 H-loop/switch region; other site 101510005973 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510005974 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 101510005975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510005976 putative PBP binding loops; other site 101510005977 dimer interface [polypeptide binding]; other site 101510005978 ABC-ATPase subunit interface; other site 101510005979 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 101510005980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510005981 dimer interface [polypeptide binding]; other site 101510005982 conserved gate region; other site 101510005983 putative PBP binding loops; other site 101510005984 ABC-ATPase subunit interface; other site 101510005985 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 101510005986 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 101510005987 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510005988 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510005989 active site 101510005990 non-prolyl cis peptide bond; other site 101510005991 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510005992 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 101510005993 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 101510005994 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510005995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510005996 Coenzyme A binding pocket [chemical binding]; other site 101510005997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510005998 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510005999 substrate binding pocket [chemical binding]; other site 101510006000 membrane-bound complex binding site; other site 101510006001 hinge residues; other site 101510006002 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510006003 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510006004 Walker A/P-loop; other site 101510006005 ATP binding site [chemical binding]; other site 101510006006 Q-loop/lid; other site 101510006007 ABC transporter signature motif; other site 101510006008 Walker B; other site 101510006009 D-loop; other site 101510006010 H-loop/switch region; other site 101510006011 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 101510006012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510006013 dimer interface [polypeptide binding]; other site 101510006014 conserved gate region; other site 101510006015 putative PBP binding loops; other site 101510006016 ABC-ATPase subunit interface; other site 101510006017 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510006018 hypothetical protein; Provisional; Region: PRK10621 101510006019 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 101510006020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510006021 active site 101510006022 motif I; other site 101510006023 motif II; other site 101510006024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510006025 active site 101510006026 motif I; other site 101510006027 motif II; other site 101510006028 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 101510006029 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 101510006030 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 101510006031 homodimer interface [polypeptide binding]; other site 101510006032 substrate-cofactor binding pocket; other site 101510006033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510006034 catalytic residue [active] 101510006035 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 101510006036 active site residue [active] 101510006037 ferredoxin-NADP+ reductase; Region: PLN02852 101510006038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510006039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510006042 active site 101510006043 Protein of unknown function (DUF456); Region: DUF456; pfam04306 101510006044 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 101510006045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510006046 ATP-grasp domain; Region: ATP-grasp; pfam02222 101510006047 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 101510006048 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 101510006049 putative DNA binding site [nucleotide binding]; other site 101510006050 catalytic residue [active] 101510006051 putative H2TH interface [polypeptide binding]; other site 101510006052 putative catalytic residues [active] 101510006053 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 101510006054 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 101510006055 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 101510006056 active site 101510006057 SAM binding site [chemical binding]; other site 101510006058 homodimer interface [polypeptide binding]; other site 101510006059 thymidylate synthase; Reviewed; Region: thyA; PRK01827 101510006060 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 101510006061 dimerization interface [polypeptide binding]; other site 101510006062 active site 101510006063 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 101510006064 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 101510006065 folate binding site [chemical binding]; other site 101510006066 NADP+ binding site [chemical binding]; other site 101510006067 Cupin domain; Region: Cupin_2; cl17218 101510006068 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 101510006069 gating phenylalanine in ion channel; other site 101510006070 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 101510006071 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 101510006072 GAF domain; Region: GAF_3; pfam13492 101510006073 GAF domain; Region: GAF_2; pfam13185 101510006074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510006075 Histidine kinase; Region: HisKA_3; pfam07730 101510006076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510006077 ATP binding site [chemical binding]; other site 101510006078 Mg2+ binding site [ion binding]; other site 101510006079 G-X-G motif; other site 101510006080 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510006081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510006082 active site 101510006083 phosphorylation site [posttranslational modification] 101510006084 intermolecular recognition site; other site 101510006085 dimerization interface [polypeptide binding]; other site 101510006086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510006087 DNA binding residues [nucleotide binding] 101510006088 dimerization interface [polypeptide binding]; other site 101510006089 hypothetical protein; Provisional; Region: PRK14851 101510006090 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 101510006091 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 101510006092 homodimer interface [polypeptide binding]; other site 101510006093 putative substrate binding pocket [chemical binding]; other site 101510006094 diiron center [ion binding]; other site 101510006095 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510006096 Ligand Binding Site [chemical binding]; other site 101510006097 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510006098 Ligand Binding Site [chemical binding]; other site 101510006099 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 101510006100 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510006101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510006102 Ligand Binding Site [chemical binding]; other site 101510006103 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510006104 Ligand Binding Site [chemical binding]; other site 101510006105 Rrf2 family protein; Region: rrf2_super; TIGR00738 101510006106 Transcriptional regulator; Region: Rrf2; cl17282 101510006107 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 101510006108 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 101510006109 heme-binding site [chemical binding]; other site 101510006110 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 101510006111 FAD binding pocket [chemical binding]; other site 101510006112 FAD binding motif [chemical binding]; other site 101510006113 phosphate binding motif [ion binding]; other site 101510006114 beta-alpha-beta structure motif; other site 101510006115 NAD binding pocket [chemical binding]; other site 101510006116 Heme binding pocket [chemical binding]; other site 101510006117 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 101510006118 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510006119 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510006120 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 101510006121 Dienelactone hydrolase family; Region: DLH; pfam01738 101510006122 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 101510006123 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 101510006124 active site 101510006125 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 101510006126 RNA/DNA hybrid binding site [nucleotide binding]; other site 101510006127 active site 101510006128 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 101510006129 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 101510006130 minor groove reading motif; other site 101510006131 helix-hairpin-helix signature motif; other site 101510006132 active site 101510006133 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 101510006134 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 101510006135 PDGLE domain; Region: PDGLE; pfam13190 101510006136 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 101510006137 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 101510006138 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 101510006139 Walker A/P-loop; other site 101510006140 ATP binding site [chemical binding]; other site 101510006141 Q-loop/lid; other site 101510006142 ABC transporter signature motif; other site 101510006143 Walker B; other site 101510006144 D-loop; other site 101510006145 H-loop/switch region; other site 101510006146 Methyltransferase domain; Region: Methyltransf_31; pfam13847 101510006147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510006148 S-adenosylmethionine binding site [chemical binding]; other site 101510006149 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510006150 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510006151 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510006152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510006153 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510006154 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510006155 acyl-activating enzyme (AAE) consensus motif; other site 101510006156 putative AMP binding site [chemical binding]; other site 101510006157 putative active site [active] 101510006158 acyl-activating enzyme (AAE) consensus motif; other site 101510006159 putative CoA binding site [chemical binding]; other site 101510006160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510006161 enoyl-CoA hydratase; Provisional; Region: PRK08252 101510006162 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510006163 substrate binding site [chemical binding]; other site 101510006164 oxyanion hole (OAH) forming residues; other site 101510006165 trimer interface [polypeptide binding]; other site 101510006166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510006167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510006168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 101510006169 dimerization interface [polypeptide binding]; other site 101510006170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510006171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510006172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 101510006173 dimerization interface [polypeptide binding]; other site 101510006174 enoyl-CoA hydratase; Provisional; Region: PRK06688 101510006175 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510006176 substrate binding site [chemical binding]; other site 101510006177 oxyanion hole (OAH) forming residues; other site 101510006178 trimer interface [polypeptide binding]; other site 101510006179 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 101510006180 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 101510006181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510006182 acyl-activating enzyme (AAE) consensus motif; other site 101510006183 AMP binding site [chemical binding]; other site 101510006184 active site 101510006185 CoA binding site [chemical binding]; other site 101510006186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510006187 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 101510006188 NAD(P) binding site [chemical binding]; other site 101510006189 active site 101510006190 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 101510006191 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510006192 dimer interface [polypeptide binding]; other site 101510006193 active site 101510006194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006195 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510006196 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510006197 active site 101510006198 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 101510006199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510006200 S-adenosylmethionine binding site [chemical binding]; other site 101510006201 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 101510006202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510006203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 101510006204 dimer interface [polypeptide binding]; other site 101510006205 phosphorylation site [posttranslational modification] 101510006206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510006207 ATP binding site [chemical binding]; other site 101510006208 Mg2+ binding site [ion binding]; other site 101510006209 G-X-G motif; other site 101510006210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510006211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510006212 active site 101510006213 phosphorylation site [posttranslational modification] 101510006214 intermolecular recognition site; other site 101510006215 dimerization interface [polypeptide binding]; other site 101510006216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510006217 DNA binding site [nucleotide binding] 101510006218 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 101510006219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006220 putative substrate translocation pore; other site 101510006221 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510006222 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510006223 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510006224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510006225 active site 101510006226 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510006227 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510006228 DNA binding site [nucleotide binding] 101510006229 domain linker motif; other site 101510006230 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 101510006231 putative dimerization interface [polypeptide binding]; other site 101510006232 putative ligand binding site [chemical binding]; other site 101510006233 acyl-CoA synthetase; Validated; Region: PRK08316 101510006234 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510006235 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510006236 acyl-activating enzyme (AAE) consensus motif; other site 101510006237 acyl-activating enzyme (AAE) consensus motif; other site 101510006238 putative AMP binding site [chemical binding]; other site 101510006239 putative active site [active] 101510006240 putative CoA binding site [chemical binding]; other site 101510006241 enoyl-CoA hydratase; Validated; Region: PRK08139 101510006242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510006243 substrate binding site [chemical binding]; other site 101510006244 oxyanion hole (OAH) forming residues; other site 101510006245 trimer interface [polypeptide binding]; other site 101510006246 fumarylacetoacetase; Region: PLN02856 101510006247 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 101510006248 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510006249 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 101510006250 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510006251 MarR family; Region: MarR; pfam01047 101510006252 MarR family; Region: MarR_2; cl17246 101510006253 spermidine synthase; Provisional; Region: PRK03612 101510006254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510006255 S-adenosylmethionine binding site [chemical binding]; other site 101510006256 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 101510006257 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 101510006258 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 101510006259 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 101510006260 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 101510006261 Isochorismatase family; Region: Isochorismatase; pfam00857 101510006262 catalytic triad [active] 101510006263 conserved cis-peptide bond; other site 101510006264 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510006265 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510006266 acyl-activating enzyme (AAE) consensus motif; other site 101510006267 AMP binding site [chemical binding]; other site 101510006268 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510006269 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510006270 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510006271 acyl-activating enzyme (AAE) consensus motif; other site 101510006272 AMP binding site [chemical binding]; other site 101510006273 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510006274 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 101510006275 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 101510006276 siderophore binding site; other site 101510006277 enterobactin exporter EntS; Provisional; Region: PRK10489 101510006278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006279 putative substrate translocation pore; other site 101510006280 Phosphopantetheine attachment site; Region: PP-binding; cl09936 101510006281 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 101510006282 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 101510006283 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 101510006284 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 101510006285 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 101510006286 active site 101510006287 DNA binding site [nucleotide binding] 101510006288 catalytic site [active] 101510006289 Transport protein; Region: actII; TIGR00833 101510006290 Transport protein; Region: actII; TIGR00833 101510006291 AlkA N-terminal domain; Region: AlkA_N; pfam06029 101510006292 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 101510006293 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 101510006294 minor groove reading motif; other site 101510006295 helix-hairpin-helix signature motif; other site 101510006296 substrate binding pocket [chemical binding]; other site 101510006297 active site 101510006298 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 101510006299 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 101510006300 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 101510006301 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 101510006302 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 101510006303 DNA binding site [nucleotide binding] 101510006304 active site 101510006305 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 101510006306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510006307 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 101510006308 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 101510006309 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 101510006310 DNA binding site [nucleotide binding] 101510006311 active site 101510006312 short chain dehydrogenase; Provisional; Region: PRK07326 101510006313 classical (c) SDRs; Region: SDR_c; cd05233 101510006314 NAD(P) binding site [chemical binding]; other site 101510006315 active site 101510006316 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510006317 putative active site [active] 101510006318 putative substrate binding site [chemical binding]; other site 101510006319 ATP binding site [chemical binding]; other site 101510006320 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510006321 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510006322 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510006323 active site 101510006324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006326 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 101510006327 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510006328 hydrophobic ligand binding site; other site 101510006329 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510006330 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 101510006331 NAD(P) binding site [chemical binding]; other site 101510006332 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510006333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510006334 NAD(P) binding site [chemical binding]; other site 101510006335 active site 101510006336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510006337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510006338 active site 101510006339 classical (c) SDRs; Region: SDR_c; cd05233 101510006340 NAD(P) binding site [chemical binding]; other site 101510006341 active site 101510006342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006344 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510006345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510006346 NAD(P) binding site [chemical binding]; other site 101510006347 active site 101510006348 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510006349 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510006350 active site 101510006351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006353 Domain of unknown function (DUF1973); Region: DUF1973; pfam09315 101510006354 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510006355 active site 101510006356 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 101510006357 EspG family; Region: ESX-1_EspG; pfam14011 101510006358 Domain of unknown function (DUF309); Region: DUF309; pfam03745 101510006359 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 101510006360 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510006361 Cytochrome P450; Region: p450; cl12078 101510006362 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 101510006363 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 101510006364 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 101510006365 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510006366 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 101510006367 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 101510006368 MarR family; Region: MarR_2; pfam12802 101510006369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006370 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510006371 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510006372 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 101510006373 ATP-binding site [chemical binding]; other site 101510006374 Gluconate-6-phosphate binding site [chemical binding]; other site 101510006375 Shikimate kinase; Region: SKI; pfam01202 101510006376 GntP family permease; Region: GntP_permease; pfam02447 101510006377 fructuronate transporter; Provisional; Region: PRK10034; cl15264 101510006378 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510006379 FCD domain; Region: FCD; pfam07729 101510006380 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 101510006381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006382 putative substrate translocation pore; other site 101510006383 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 101510006384 non-specific DNA interactions [nucleotide binding]; other site 101510006385 DNA binding site [nucleotide binding] 101510006386 sequence specific DNA binding site [nucleotide binding]; other site 101510006387 putative cAMP binding site [chemical binding]; other site 101510006388 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 101510006389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 101510006390 nucleotide binding site [chemical binding]; other site 101510006391 Entner-Doudoroff aldolase; Region: eda; TIGR01182 101510006392 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 101510006393 active site 101510006394 intersubunit interface [polypeptide binding]; other site 101510006395 catalytic residue [active] 101510006396 phosphogluconate dehydratase; Validated; Region: PRK09054 101510006397 6-phosphogluconate dehydratase; Region: edd; TIGR01196 101510006398 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 101510006399 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 101510006400 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 101510006401 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 101510006402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 101510006403 nucleotide binding site [chemical binding]; other site 101510006404 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510006405 Muconolactone delta-isomerase; Region: MIase; pfam02426 101510006406 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 101510006407 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 101510006408 octamer interface [polypeptide binding]; other site 101510006409 active site 101510006410 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 101510006411 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 101510006412 dimer interface [polypeptide binding]; other site 101510006413 active site 101510006414 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 101510006415 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510006416 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510006417 Dioxygenase; Region: Dioxygenase_C; pfam00775 101510006418 active site 101510006419 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 101510006420 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 101510006421 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 101510006422 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 101510006423 Multicopper oxidase; Region: Cu-oxidase; pfam00394 101510006424 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 101510006425 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510006426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510006427 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510006428 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 101510006429 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 101510006430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510006431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510006432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510006433 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510006434 Cytochrome P450; Region: p450; cl12078 101510006435 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 101510006436 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510006437 catalytic loop [active] 101510006438 iron binding site [ion binding]; other site 101510006439 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 101510006440 FAD binding pocket [chemical binding]; other site 101510006441 FAD binding motif [chemical binding]; other site 101510006442 phosphate binding motif [ion binding]; other site 101510006443 beta-alpha-beta structure motif; other site 101510006444 NAD binding pocket [chemical binding]; other site 101510006445 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 101510006446 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 101510006447 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 101510006448 putative alpha subunit interface [polypeptide binding]; other site 101510006449 putative active site [active] 101510006450 putative substrate binding site [chemical binding]; other site 101510006451 Fe binding site [ion binding]; other site 101510006452 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 101510006453 inter-subunit interface; other site 101510006454 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 101510006455 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510006456 catalytic loop [active] 101510006457 iron binding site [ion binding]; other site 101510006458 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 101510006459 FAD binding pocket [chemical binding]; other site 101510006460 FAD binding motif [chemical binding]; other site 101510006461 phosphate binding motif [ion binding]; other site 101510006462 beta-alpha-beta structure motif; other site 101510006463 NAD binding pocket [chemical binding]; other site 101510006464 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510006465 FCD domain; Region: FCD; pfam07729 101510006466 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 101510006467 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 101510006468 putative NAD(P) binding site [chemical binding]; other site 101510006469 active site 101510006470 benzoate transport; Region: 2A0115; TIGR00895 101510006471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006472 putative substrate translocation pore; other site 101510006473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006474 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 101510006475 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 101510006476 TPP-binding site [chemical binding]; other site 101510006477 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 101510006478 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 101510006479 dimer interface [polypeptide binding]; other site 101510006480 PYR/PP interface [polypeptide binding]; other site 101510006481 TPP binding site [chemical binding]; other site 101510006482 substrate binding site [chemical binding]; other site 101510006483 AAA ATPase domain; Region: AAA_16; pfam13191 101510006484 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510006485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510006486 DNA binding residues [nucleotide binding] 101510006487 dimerization interface [polypeptide binding]; other site 101510006488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 101510006489 Domain of unknown function (DUF222); Region: DUF222; pfam02720 101510006490 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510006491 active site 101510006492 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 101510006493 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 101510006494 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 101510006495 Condensation domain; Region: Condensation; pfam00668 101510006496 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510006497 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510006498 acyl-activating enzyme (AAE) consensus motif; other site 101510006499 AMP binding site [chemical binding]; other site 101510006500 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510006501 Condensation domain; Region: Condensation; pfam00668 101510006502 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510006503 Condensation domain; Region: Condensation; pfam00668 101510006504 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510006505 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510006506 acyl-activating enzyme (AAE) consensus motif; other site 101510006507 AMP binding site [chemical binding]; other site 101510006508 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510006509 Condensation domain; Region: Condensation; pfam00668 101510006510 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510006511 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510006512 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510006513 acyl-activating enzyme (AAE) consensus motif; other site 101510006514 AMP binding site [chemical binding]; other site 101510006515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510006516 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510006517 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510006518 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510006519 acyl-activating enzyme (AAE) consensus motif; other site 101510006520 AMP binding site [chemical binding]; other site 101510006521 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510006522 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 101510006523 aconitate hydratase; Validated; Region: PRK07229 101510006524 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 101510006525 substrate binding site [chemical binding]; other site 101510006526 ligand binding site [chemical binding]; other site 101510006527 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 101510006528 substrate binding site [chemical binding]; other site 101510006529 AAA ATPase domain; Region: AAA_16; pfam13191 101510006530 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 101510006531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510006532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510006533 DNA binding residues [nucleotide binding] 101510006534 VPS10 domain; Region: VPS10; smart00602 101510006535 Ubiquitin-like proteins; Region: UBQ; cl00155 101510006536 charged pocket; other site 101510006537 hydrophobic patch; other site 101510006538 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 101510006539 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510006540 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510006541 active site 101510006542 ATP binding site [chemical binding]; other site 101510006543 substrate binding site [chemical binding]; other site 101510006544 activation loop (A-loop); other site 101510006545 Archaeal ATPase; Region: Arch_ATPase; pfam01637 101510006546 AAA ATPase domain; Region: AAA_16; pfam13191 101510006547 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 101510006548 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 101510006549 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 101510006550 CGNR zinc finger; Region: zf-CGNR; pfam11706 101510006551 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 101510006552 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510006553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510006554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510006555 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 101510006556 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 101510006557 active site 101510006558 dimer interface [polypeptide binding]; other site 101510006559 non-prolyl cis peptide bond; other site 101510006560 insertion regions; other site 101510006561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006562 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510006563 putative substrate translocation pore; other site 101510006564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006566 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510006567 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510006568 FAD binding domain; Region: FAD_binding_2; pfam00890 101510006569 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 101510006570 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 101510006571 active site 101510006572 dimer interface [polypeptide binding]; other site 101510006573 non-prolyl cis peptide bond; other site 101510006574 insertion regions; other site 101510006575 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 101510006576 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510006577 active site 101510006578 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510006579 hypothetical protein; Provisional; Region: PRK07236 101510006580 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510006581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006582 putative substrate translocation pore; other site 101510006583 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510006584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510006585 dimerization interface [polypeptide binding]; other site 101510006586 putative DNA binding site [nucleotide binding]; other site 101510006587 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 101510006588 diiron binding motif [ion binding]; other site 101510006589 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 101510006590 Uncharacterized conserved protein [Function unknown]; Region: COG1434 101510006591 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 101510006592 putative active site [active] 101510006593 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 101510006594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006596 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 101510006597 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510006598 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 101510006599 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 101510006600 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 101510006601 NAD(P) binding site [chemical binding]; other site 101510006602 active site 101510006603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510006604 dimerization interface [polypeptide binding]; other site 101510006605 putative DNA binding site [nucleotide binding]; other site 101510006606 putative Zn2+ binding site [ion binding]; other site 101510006607 Protein of unknown function DUF72; Region: DUF72; pfam01904 101510006608 GYD domain; Region: GYD; pfam08734 101510006609 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 101510006610 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 101510006611 ABC1 family; Region: ABC1; cl17513 101510006612 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 101510006613 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510006614 putative metal binding site [ion binding]; other site 101510006615 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 101510006616 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 101510006617 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510006618 putative metal binding site [ion binding]; other site 101510006619 Tellurium resistance protein; Region: Tellurium_res; pfam10138 101510006620 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 101510006621 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510006622 putative metal binding site [ion binding]; other site 101510006623 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 101510006624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510006625 active site 101510006626 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 101510006627 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510006628 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 101510006629 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510006630 putative metal binding site [ion binding]; other site 101510006631 hypothetical protein; Provisional; Region: PRK14013 101510006632 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 101510006633 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 101510006634 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 101510006635 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 101510006636 TrkA-N domain; Region: TrkA_N; pfam02254 101510006637 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 101510006638 homotrimer interaction site [polypeptide binding]; other site 101510006639 putative active site [active] 101510006640 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510006641 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510006642 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510006643 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 101510006644 substrate binding site [chemical binding]; other site 101510006645 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 101510006646 ATP binding site [chemical binding]; other site 101510006647 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 101510006648 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 101510006649 dimer interface [polypeptide binding]; other site 101510006650 active site 101510006651 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 101510006652 substrate binding site [chemical binding]; other site 101510006653 catalytic residue [active] 101510006654 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 101510006655 active site 101510006656 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510006657 putative substrate binding pocket [chemical binding]; other site 101510006658 active site 101510006659 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510006660 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510006661 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 101510006662 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 101510006663 active site 101510006664 intersubunit interface [polypeptide binding]; other site 101510006665 catalytic residue [active] 101510006666 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 101510006667 fructuronate transporter; Provisional; Region: PRK10034; cl15264 101510006668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 101510006669 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 101510006670 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 101510006671 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 101510006672 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 101510006673 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510006674 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510006675 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 101510006676 shikimate transporter; Provisional; Region: PRK09952 101510006677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006678 putative substrate translocation pore; other site 101510006679 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 101510006680 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 101510006681 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510006682 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510006683 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 101510006684 Phosphoesterase family; Region: Phosphoesterase; pfam04185 101510006685 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 101510006686 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 101510006687 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510006688 classical (c) SDRs; Region: SDR_c; cd05233 101510006689 NAD(P) binding site [chemical binding]; other site 101510006690 active site 101510006691 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510006692 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510006693 classical (c) SDRs; Region: SDR_c; cd05233 101510006694 NAD(P) binding site [chemical binding]; other site 101510006695 active site 101510006696 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510006697 classical (c) SDRs; Region: SDR_c; cd05233 101510006698 NAD(P) binding site [chemical binding]; other site 101510006699 active site 101510006700 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 101510006701 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510006702 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510006703 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510006704 Transcriptional regulator PadR-like family; Region: PadR; cl17335 101510006705 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510006706 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510006707 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510006708 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510006709 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510006710 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510006711 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 101510006712 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 101510006713 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 101510006714 active site 101510006715 Fe binding site [ion binding]; other site 101510006716 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510006717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510006718 active site 101510006719 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510006720 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 101510006721 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510006722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510006723 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 101510006724 Condensation domain; Region: Condensation; pfam00668 101510006725 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510006726 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510006727 acyl-activating enzyme (AAE) consensus motif; other site 101510006728 AMP binding site [chemical binding]; other site 101510006729 Condensation domain; Region: Condensation; pfam00668 101510006730 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510006731 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510006732 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 101510006733 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510006734 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 101510006735 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510006736 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 101510006737 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 101510006738 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 101510006739 NAD binding site [chemical binding]; other site 101510006740 catalytic Zn binding site [ion binding]; other site 101510006741 substrate binding site [chemical binding]; other site 101510006742 structural Zn binding site [ion binding]; other site 101510006743 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510006744 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510006745 NAD(P) binding site [chemical binding]; other site 101510006746 catalytic residues [active] 101510006747 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510006748 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 101510006749 Secretory lipase; Region: LIP; pfam03583 101510006750 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510006751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510006752 putative substrate translocation pore; other site 101510006753 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 101510006754 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 101510006755 metal binding site [ion binding]; metal-binding site 101510006756 dimer interface [polypeptide binding]; other site 101510006757 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510006758 AsnC family; Region: AsnC_trans_reg; pfam01037 101510006759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 101510006760 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510006761 AsnC family; Region: AsnC_trans_reg; pfam01037 101510006762 Protein of unknown function (DUF664); Region: DUF664; pfam04978 101510006763 DinB superfamily; Region: DinB_2; pfam12867 101510006764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510006765 S-adenosylmethionine binding site [chemical binding]; other site 101510006766 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 101510006767 ANTAR domain; Region: ANTAR; cl04297 101510006768 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 101510006769 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510006770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510006771 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510006772 Cytochrome P450; Region: p450; cl12078 101510006773 Domain of unknown function (DUF222); Region: DUF222; pfam02720 101510006774 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510006775 active site 101510006776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510006777 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510006778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510006779 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510006780 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 101510006781 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 101510006782 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 101510006783 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 101510006784 active site 101510006785 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510006786 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 101510006787 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510006788 dimer interface [polypeptide binding]; other site 101510006789 active site 101510006790 acyl-CoA synthetase; Validated; Region: PRK06164 101510006791 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510006792 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510006793 acyl-activating enzyme (AAE) consensus motif; other site 101510006794 AMP binding site [chemical binding]; other site 101510006795 active site 101510006796 CoA binding site [chemical binding]; other site 101510006797 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510006798 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510006799 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510006800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510006801 active site 101510006802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006804 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 101510006805 Protein of unknown function, DUF485; Region: DUF485; pfam04341 101510006806 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 101510006807 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 101510006808 Na binding site [ion binding]; other site 101510006809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 101510006810 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510006811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006813 Uncharacterized conserved protein [Function unknown]; Region: COG1359 101510006814 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 101510006815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510006816 motif II; other site 101510006817 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 101510006818 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 101510006819 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 101510006820 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 101510006821 Fatty acid desaturase; Region: FA_desaturase; pfam00487 101510006822 Di-iron ligands [ion binding]; other site 101510006823 Rubredoxin [Energy production and conversion]; Region: COG1773 101510006824 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 101510006825 iron binding site [ion binding]; other site 101510006826 Rubredoxin [Energy production and conversion]; Region: COG1773 101510006827 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 101510006828 iron binding site [ion binding]; other site 101510006829 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510006830 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510006831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510006832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510006833 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 101510006834 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510006835 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510006836 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510006837 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510006838 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 101510006839 benzoate transport; Region: 2A0115; TIGR00895 101510006840 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 101510006841 dimer interface [polypeptide binding]; other site 101510006842 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510006843 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 101510006844 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510006845 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 101510006846 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 101510006847 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 101510006848 ABC-ATPase subunit interface; other site 101510006849 dimer interface [polypeptide binding]; other site 101510006850 putative PBP binding regions; other site 101510006851 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 101510006852 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 101510006853 intersubunit interface [polypeptide binding]; other site 101510006854 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 101510006855 Protein of unknown function (DUF419); Region: DUF419; pfam04237 101510006856 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 101510006857 putative hydrophobic ligand binding site [chemical binding]; other site 101510006858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510006859 TIGR01777 family protein; Region: yfcH 101510006860 NAD(P) binding site [chemical binding]; other site 101510006861 active site 101510006862 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 101510006863 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 101510006864 putative NAD(P) binding site [chemical binding]; other site 101510006865 putative active site [active] 101510006866 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 101510006867 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 101510006868 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 101510006869 Fasciclin domain; Region: Fasciclin; pfam02469 101510006870 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510006871 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 101510006872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510006873 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 101510006874 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 101510006875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510006876 S-adenosylmethionine binding site [chemical binding]; other site 101510006877 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 101510006878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510006879 S-adenosylmethionine binding site [chemical binding]; other site 101510006880 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 101510006881 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 101510006882 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510006883 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510006884 DNA binding residues [nucleotide binding] 101510006885 putative anti-sigmaE protein; Provisional; Region: PRK13920 101510006886 Anti-sigma-K factor rskA; Region: RskA; pfam10099 101510006887 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 101510006888 active site 101510006889 pyruvate kinase; Provisional; Region: PRK06247 101510006890 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 101510006891 domain interfaces; other site 101510006892 active site 101510006893 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 101510006894 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 101510006895 dimer interface [polypeptide binding]; other site 101510006896 TPP-binding site [chemical binding]; other site 101510006897 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 101510006898 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 101510006899 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 101510006900 Na binding site [ion binding]; other site 101510006901 putative substrate binding site [chemical binding]; other site 101510006902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510006903 Probable transposase; Region: OrfB_IS605; pfam01385 101510006904 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510006905 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 101510006906 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 101510006907 Malic enzyme, N-terminal domain; Region: malic; pfam00390 101510006908 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 101510006909 putative NAD(P) binding site [chemical binding]; other site 101510006910 allantoicase; Provisional; Region: PRK13257 101510006911 Allantoicase repeat; Region: Allantoicase; pfam03561 101510006912 Allantoicase repeat; Region: Allantoicase; pfam03561 101510006913 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 101510006914 glyoxylate carboligase; Provisional; Region: PRK11269 101510006915 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510006916 PYR/PP interface [polypeptide binding]; other site 101510006917 dimer interface [polypeptide binding]; other site 101510006918 TPP binding site [chemical binding]; other site 101510006919 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510006920 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 101510006921 TPP-binding site [chemical binding]; other site 101510006922 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 101510006923 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510006924 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 101510006925 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 101510006926 putative active site pocket [active] 101510006927 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 101510006928 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 101510006929 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 101510006930 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510006931 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510006932 putative DNA binding site [nucleotide binding]; other site 101510006933 putative Zn2+ binding site [ion binding]; other site 101510006934 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510006935 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510006936 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510006937 active site 101510006938 ATP binding site [chemical binding]; other site 101510006939 substrate binding site [chemical binding]; other site 101510006940 activation loop (A-loop); other site 101510006941 Clp amino terminal domain; Region: Clp_N; pfam02861 101510006942 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510006943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510006944 DNA binding residues [nucleotide binding] 101510006945 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 101510006946 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 101510006947 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 101510006948 putative molybdopterin cofactor binding site [chemical binding]; other site 101510006949 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 101510006950 putative molybdopterin cofactor binding site; other site 101510006951 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510006952 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 101510006953 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 101510006954 NAD binding site [chemical binding]; other site 101510006955 catalytic Zn binding site [ion binding]; other site 101510006956 substrate binding site [chemical binding]; other site 101510006957 structural Zn binding site [ion binding]; other site 101510006958 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 101510006959 active sites [active] 101510006960 tetramer interface [polypeptide binding]; other site 101510006961 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 101510006962 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 101510006963 Walker A/P-loop; other site 101510006964 ATP binding site [chemical binding]; other site 101510006965 Q-loop/lid; other site 101510006966 ABC transporter signature motif; other site 101510006967 Walker B; other site 101510006968 D-loop; other site 101510006969 H-loop/switch region; other site 101510006970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510006971 dimer interface [polypeptide binding]; other site 101510006972 conserved gate region; other site 101510006973 ABC-ATPase subunit interface; other site 101510006974 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 101510006975 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 101510006976 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 101510006977 nucleoside/Zn binding site; other site 101510006978 dimer interface [polypeptide binding]; other site 101510006979 catalytic motif [active] 101510006980 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510006981 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510006982 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 101510006983 Sulfatase; Region: Sulfatase; pfam00884 101510006984 Sulfatase; Region: Sulfatase; cl17466 101510006985 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 101510006986 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510006987 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 101510006988 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510006989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510006990 DNA-binding site [nucleotide binding]; DNA binding site 101510006991 FCD domain; Region: FCD; pfam07729 101510006992 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510006993 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510006994 short chain dehydrogenase; Provisional; Region: PRK08303 101510006995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510006996 NAD(P) binding site [chemical binding]; other site 101510006997 active site 101510006998 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 101510006999 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 101510007000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510007001 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 101510007002 Walker A/P-loop; other site 101510007003 ATP binding site [chemical binding]; other site 101510007004 Q-loop/lid; other site 101510007005 ABC transporter signature motif; other site 101510007006 Walker B; other site 101510007007 D-loop; other site 101510007008 H-loop/switch region; other site 101510007009 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510007010 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510007011 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510007012 Cytochrome P450; Region: p450; cl12078 101510007013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510007014 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510007015 catalytic site [active] 101510007016 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510007017 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 101510007018 Amidohydrolase; Region: Amidohydro_2; pfam04909 101510007019 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510007020 tyramine oxidase; Provisional; Region: tynA; PRK11504 101510007021 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 101510007022 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 101510007023 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 101510007024 Amino acid permease; Region: AA_permease_2; pfam13520 101510007025 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510007026 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510007027 NAD(P) binding site [chemical binding]; other site 101510007028 catalytic residues [active] 101510007029 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510007030 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510007031 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 101510007032 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510007033 short chain dehydrogenase; Provisional; Region: PRK07825 101510007034 classical (c) SDRs; Region: SDR_c; cd05233 101510007035 NAD(P) binding site [chemical binding]; other site 101510007036 active site 101510007037 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510007038 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510007039 active site 101510007040 non-prolyl cis peptide bond; other site 101510007041 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 101510007042 active site 101510007043 catalytic triad [active] 101510007044 oxyanion hole [active] 101510007045 Transcription factor WhiB; Region: Whib; pfam02467 101510007046 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510007047 Transcriptional regulator PadR-like family; Region: PadR; cl17335 101510007048 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 101510007049 active site 101510007050 catalytic residues [active] 101510007051 metal binding site [ion binding]; metal-binding site 101510007052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510007053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510007054 active site 101510007055 phosphorylation site [posttranslational modification] 101510007056 intermolecular recognition site; other site 101510007057 dimerization interface [polypeptide binding]; other site 101510007058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510007059 DNA binding residues [nucleotide binding] 101510007060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510007061 Response regulator receiver domain; Region: Response_reg; pfam00072 101510007062 active site 101510007063 phosphorylation site [posttranslational modification] 101510007064 intermolecular recognition site; other site 101510007065 dimerization interface [polypeptide binding]; other site 101510007066 GAF domain; Region: GAF_2; pfam13185 101510007067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510007068 Histidine kinase; Region: HisKA_3; pfam07730 101510007069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510007071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007072 active site 101510007073 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510007074 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510007075 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510007076 AMP binding site [chemical binding]; other site 101510007077 active site 101510007078 acyl-activating enzyme (AAE) consensus motif; other site 101510007079 CoA binding site [chemical binding]; other site 101510007080 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 101510007081 classical (c) SDRs; Region: SDR_c; cd05233 101510007082 NAD(P) binding site [chemical binding]; other site 101510007083 active site 101510007084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510007085 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 101510007086 substrate binding site [chemical binding]; other site 101510007087 oxyanion hole (OAH) forming residues; other site 101510007088 trimer interface [polypeptide binding]; other site 101510007089 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510007090 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007091 active site 101510007092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007094 TIGR03086 family protein; Region: TIGR03086 101510007095 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510007096 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 101510007097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007099 Domain of unknown function (DUF385); Region: DUF385; cl04387 101510007100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510007101 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 101510007102 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510007103 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 101510007104 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510007105 NAD binding site [chemical binding]; other site 101510007106 catalytic residues [active] 101510007107 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 101510007108 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 101510007109 catalytic Zn binding site [ion binding]; other site 101510007110 NAD binding site [chemical binding]; other site 101510007111 structural Zn binding site [ion binding]; other site 101510007112 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510007113 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 101510007114 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510007115 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510007116 acyl-activating enzyme (AAE) consensus motif; other site 101510007117 AMP binding site [chemical binding]; other site 101510007118 active site 101510007119 CoA binding site [chemical binding]; other site 101510007120 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510007121 Cytochrome P450; Region: p450; cl12078 101510007122 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 101510007123 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 101510007124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 101510007125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510007126 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510007127 active site 101510007128 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 101510007129 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510007130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007132 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510007133 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510007134 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510007135 acyl-activating enzyme (AAE) consensus motif; other site 101510007136 acyl-activating enzyme (AAE) consensus motif; other site 101510007137 putative AMP binding site [chemical binding]; other site 101510007138 putative active site [active] 101510007139 putative CoA binding site [chemical binding]; other site 101510007140 SCP-2 sterol transfer family; Region: SCP2; cl01225 101510007141 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 101510007142 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510007143 NAD binding site [chemical binding]; other site 101510007144 catalytic residues [active] 101510007145 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 101510007146 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 101510007147 catalytic Zn binding site [ion binding]; other site 101510007148 NAD binding site [chemical binding]; other site 101510007149 structural Zn binding site [ion binding]; other site 101510007150 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510007151 Secretory lipase; Region: LIP; pfam03583 101510007152 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 101510007153 homodimer interface [polypeptide binding]; other site 101510007154 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 101510007155 putative NAD(P) binding site [chemical binding]; other site 101510007156 active site 101510007157 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510007158 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510007159 substrate binding site [chemical binding]; other site 101510007160 oxyanion hole (OAH) forming residues; other site 101510007161 trimer interface [polypeptide binding]; other site 101510007162 active site 1 [active] 101510007163 dimer interface [polypeptide binding]; other site 101510007164 hexamer interface [polypeptide binding]; other site 101510007165 active site 2 [active] 101510007166 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 101510007167 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510007168 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 101510007169 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 101510007170 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510007171 acyl-activating enzyme (AAE) consensus motif; other site 101510007172 AMP binding site [chemical binding]; other site 101510007173 active site 101510007174 CoA binding site [chemical binding]; other site 101510007175 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510007176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510007177 Predicted ATPase [General function prediction only]; Region: COG3903 101510007178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510007179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510007180 DNA binding residues [nucleotide binding] 101510007181 dimerization interface [polypeptide binding]; other site 101510007182 Excalibur calcium-binding domain; Region: Excalibur; smart00894 101510007183 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 101510007184 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510007185 putative active site [active] 101510007186 putative FMN binding site [chemical binding]; other site 101510007187 putative substrate binding site [chemical binding]; other site 101510007188 putative catalytic residue [active] 101510007189 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510007190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007191 putative substrate translocation pore; other site 101510007192 succinic semialdehyde dehydrogenase; Region: PLN02278 101510007193 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 101510007194 tetramerization interface [polypeptide binding]; other site 101510007195 NAD(P) binding site [chemical binding]; other site 101510007196 catalytic residues [active] 101510007197 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 101510007198 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510007199 NAD(P) binding site [chemical binding]; other site 101510007200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510007201 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 101510007202 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 101510007203 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510007204 FMN binding site [chemical binding]; other site 101510007205 substrate binding site [chemical binding]; other site 101510007206 putative catalytic residue [active] 101510007207 enoyl-CoA hydratase; Provisional; Region: PRK08260 101510007208 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510007209 substrate binding site [chemical binding]; other site 101510007210 oxyanion hole (OAH) forming residues; other site 101510007211 trimer interface [polypeptide binding]; other site 101510007212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510007215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007217 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510007218 Phosphotransferase enzyme family; Region: APH; pfam01636 101510007219 putative active site [active] 101510007220 putative substrate binding site [chemical binding]; other site 101510007221 ATP binding site [chemical binding]; other site 101510007222 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510007223 classical (c) SDRs; Region: SDR_c; cd05233 101510007224 NAD(P) binding site [chemical binding]; other site 101510007225 active site 101510007226 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510007227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007228 active site 101510007229 enoyl-CoA hydratase; Provisional; Region: PRK06210 101510007230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510007231 substrate binding site [chemical binding]; other site 101510007232 oxyanion hole (OAH) forming residues; other site 101510007233 trimer interface [polypeptide binding]; other site 101510007234 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 101510007235 classical (c) SDRs; Region: SDR_c; cd05233 101510007236 NAD(P) binding site [chemical binding]; other site 101510007237 active site 101510007238 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510007239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510007240 DNA-binding site [nucleotide binding]; DNA binding site 101510007241 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510007242 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510007243 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510007244 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 101510007245 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 101510007246 acyl-activating enzyme (AAE) consensus motif; other site 101510007247 putative AMP binding site [chemical binding]; other site 101510007248 putative active site [active] 101510007249 putative CoA binding site [chemical binding]; other site 101510007250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510007251 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510007252 enoyl-CoA hydratase; Provisional; Region: PRK08260 101510007253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510007254 substrate binding site [chemical binding]; other site 101510007255 oxyanion hole (OAH) forming residues; other site 101510007256 trimer interface [polypeptide binding]; other site 101510007257 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 101510007258 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 101510007259 acyl-activating enzyme (AAE) consensus motif; other site 101510007260 putative AMP binding site [chemical binding]; other site 101510007261 putative active site [active] 101510007262 putative CoA binding site [chemical binding]; other site 101510007263 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 101510007264 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510007265 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510007266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007268 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 101510007269 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510007270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007271 active site 101510007272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510007273 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510007274 active site 101510007275 ATP binding site [chemical binding]; other site 101510007276 substrate binding site [chemical binding]; other site 101510007277 activation loop (A-loop); other site 101510007278 Predicted ATPase [General function prediction only]; Region: COG3903 101510007279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 101510007280 TPR motif; other site 101510007281 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510007282 binding surface 101510007283 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510007284 DNA binding residues [nucleotide binding] 101510007285 dimerization interface [polypeptide binding]; other site 101510007286 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510007287 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 101510007288 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 101510007289 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 101510007290 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 101510007291 ligand binding site [chemical binding]; other site 101510007292 homodimer interface [polypeptide binding]; other site 101510007293 NAD(P) binding site [chemical binding]; other site 101510007294 trimer interface B [polypeptide binding]; other site 101510007295 trimer interface A [polypeptide binding]; other site 101510007296 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 101510007297 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510007298 Phosphotransferase enzyme family; Region: APH; pfam01636 101510007299 putative active site [active] 101510007300 putative substrate binding site [chemical binding]; other site 101510007301 ATP binding site [chemical binding]; other site 101510007302 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 101510007303 putative active site [active] 101510007304 putative catalytic site [active] 101510007305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510007306 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510007307 NAD(P) binding site [chemical binding]; other site 101510007308 active site 101510007309 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 101510007310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510007311 motif II; other site 101510007312 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510007313 classical (c) SDRs; Region: SDR_c; cd05233 101510007314 NAD(P) binding site [chemical binding]; other site 101510007315 active site 101510007316 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 101510007317 active site 101510007318 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510007319 active site 101510007320 Predicted ATPase [General function prediction only]; Region: COG3903 101510007321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510007322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510007323 DNA binding residues [nucleotide binding] 101510007324 dimerization interface [polypeptide binding]; other site 101510007325 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 101510007326 Prostaglandin dehydrogenases; Region: PGDH; cd05288 101510007327 NAD(P) binding site [chemical binding]; other site 101510007328 substrate binding site [chemical binding]; other site 101510007329 dimer interface [polypeptide binding]; other site 101510007330 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510007331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007333 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 101510007334 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510007335 dimer interface [polypeptide binding]; other site 101510007336 active site 101510007337 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510007338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510007339 NAD(P) binding site [chemical binding]; other site 101510007340 active site 101510007341 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 101510007342 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 101510007343 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007344 active site 101510007345 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 101510007346 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510007347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510007348 NAD(P) binding site [chemical binding]; other site 101510007349 active site 101510007350 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 101510007351 putative active site [active] 101510007352 putative catalytic site [active] 101510007353 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510007354 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 101510007355 active site 101510007356 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 101510007357 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 101510007358 N-acetyl-D-glucosamine binding site [chemical binding]; other site 101510007359 catalytic residue [active] 101510007360 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510007361 NlpC/P60 family; Region: NLPC_P60; pfam00877 101510007362 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 101510007363 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 101510007364 Walker A/P-loop; other site 101510007365 ATP binding site [chemical binding]; other site 101510007366 Q-loop/lid; other site 101510007367 ABC transporter signature motif; other site 101510007368 Walker B; other site 101510007369 D-loop; other site 101510007370 H-loop/switch region; other site 101510007371 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510007372 mce related protein; Region: MCE; pfam02470 101510007373 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510007374 mce related protein; Region: MCE; pfam02470 101510007375 mce related protein; Region: MCE; pfam02470 101510007376 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510007377 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510007378 mce related protein; Region: MCE; pfam02470 101510007379 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510007380 mce related protein; Region: MCE; pfam02470 101510007381 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510007382 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 101510007383 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 101510007384 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510007385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007386 active site 101510007387 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 101510007388 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 101510007389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510007390 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510007391 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510007392 Integrase core domain; Region: rve; pfam00665 101510007393 Transposase; Region: HTH_Tnp_1; cl17663 101510007394 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 101510007395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 101510007396 Transposase; Region: DDE_Tnp_ISL3; pfam01610 101510007397 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 101510007398 Clp amino terminal domain; Region: Clp_N; pfam02861 101510007399 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510007400 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510007401 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 101510007402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510007403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510007404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510007405 DNA binding residues [nucleotide binding] 101510007406 dimerization interface [polypeptide binding]; other site 101510007407 Helix-turn-helix domain; Region: HTH_38; pfam13936 101510007408 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 101510007409 Integrase core domain; Region: rve; pfam00665 101510007410 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510007411 Cytochrome P450; Region: p450; cl12078 101510007412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007414 acyl-CoA synthetase; Validated; Region: PRK06178 101510007415 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510007416 acyl-activating enzyme (AAE) consensus motif; other site 101510007417 AMP binding site [chemical binding]; other site 101510007418 active site 101510007419 CoA binding site [chemical binding]; other site 101510007420 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 101510007421 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510007422 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510007423 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 101510007424 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 101510007425 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510007426 carboxyltransferase (CT) interaction site; other site 101510007427 biotinylation site [posttranslational modification]; other site 101510007428 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 101510007429 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510007430 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 101510007431 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 101510007432 NADP binding site [chemical binding]; other site 101510007433 dimer interface [polypeptide binding]; other site 101510007434 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 101510007435 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 101510007436 putative NAD(P) binding site [chemical binding]; other site 101510007437 catalytic Zn binding site [ion binding]; other site 101510007438 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 101510007439 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 101510007440 substrate binding site [chemical binding]; other site 101510007441 ATP binding site [chemical binding]; other site 101510007442 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 101510007443 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 101510007444 active site 101510007445 intersubunit interface [polypeptide binding]; other site 101510007446 catalytic residue [active] 101510007447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007448 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510007449 putative substrate translocation pore; other site 101510007450 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 101510007451 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 101510007452 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 101510007453 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 101510007454 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 101510007455 metal binding site [ion binding]; metal-binding site 101510007456 substrate binding pocket [chemical binding]; other site 101510007457 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 101510007458 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 101510007459 putative ligand binding site [chemical binding]; other site 101510007460 NAD binding site [chemical binding]; other site 101510007461 dimer interface [polypeptide binding]; other site 101510007462 putative catalytic site [active] 101510007463 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510007464 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510007465 DNA binding site [nucleotide binding] 101510007466 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 101510007467 ligand binding site [chemical binding]; other site 101510007468 dimerization interface [polypeptide binding]; other site 101510007469 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 101510007470 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510007471 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 101510007472 active site 101510007473 dimer interface [polypeptide binding]; other site 101510007474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510007475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510007476 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 101510007477 substrate binding pocket [chemical binding]; other site 101510007478 dimerization interface [polypeptide binding]; other site 101510007479 benzoylformate decarboxylase; Reviewed; Region: PRK07092 101510007480 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510007481 PYR/PP interface [polypeptide binding]; other site 101510007482 dimer interface [polypeptide binding]; other site 101510007483 TPP binding site [chemical binding]; other site 101510007484 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510007485 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 101510007486 TPP-binding site [chemical binding]; other site 101510007487 dimer interface [polypeptide binding]; other site 101510007488 benzoate transport; Region: 2A0115; TIGR00895 101510007489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007490 putative substrate translocation pore; other site 101510007491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007492 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510007493 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 101510007494 NAD(P) binding site [chemical binding]; other site 101510007495 catalytic residues [active] 101510007496 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 101510007497 apolar tunnel; other site 101510007498 heme binding site [chemical binding]; other site 101510007499 dimerization interface [polypeptide binding]; other site 101510007500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007503 putative substrate translocation pore; other site 101510007504 MarR family; Region: MarR_2; pfam12802 101510007505 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 101510007506 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 101510007507 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 101510007508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 101510007509 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510007510 FAD binding domain; Region: FAD_binding_4; pfam01565 101510007511 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 101510007512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510007513 Walker A/P-loop; other site 101510007514 ATP binding site [chemical binding]; other site 101510007515 Q-loop/lid; other site 101510007516 ABC transporter signature motif; other site 101510007517 Walker B; other site 101510007518 D-loop; other site 101510007519 H-loop/switch region; other site 101510007520 TOBE domain; Region: TOBE_2; pfam08402 101510007521 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 101510007522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510007523 dimer interface [polypeptide binding]; other site 101510007524 conserved gate region; other site 101510007525 putative PBP binding loops; other site 101510007526 ABC-ATPase subunit interface; other site 101510007527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 101510007528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510007529 dimer interface [polypeptide binding]; other site 101510007530 conserved gate region; other site 101510007531 putative PBP binding loops; other site 101510007532 ABC-ATPase subunit interface; other site 101510007533 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 101510007534 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 101510007535 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 101510007536 MarR family; Region: MarR_2; pfam12802 101510007537 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 101510007538 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510007539 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 101510007540 inhibitor binding site; inhibition site 101510007541 catalytic Zn binding site [ion binding]; other site 101510007542 structural Zn binding site [ion binding]; other site 101510007543 NADP binding site [chemical binding]; other site 101510007544 tetramer interface [polypeptide binding]; other site 101510007545 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 101510007546 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 101510007547 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 101510007548 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 101510007549 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 101510007550 putative substrate binding site [chemical binding]; other site 101510007551 putative ATP binding site [chemical binding]; other site 101510007552 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510007553 D-xylulose kinase; Region: XylB; TIGR01312 101510007554 nucleotide binding site [chemical binding]; other site 101510007555 Prostaglandin dehydrogenases; Region: PGDH; cd05288 101510007556 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 101510007557 NAD(P) binding site [chemical binding]; other site 101510007558 substrate binding site [chemical binding]; other site 101510007559 dimer interface [polypeptide binding]; other site 101510007560 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 101510007561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007563 allantoate amidohydrolase; Reviewed; Region: PRK09290 101510007564 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 101510007565 active site 101510007566 metal binding site [ion binding]; metal-binding site 101510007567 dimer interface [polypeptide binding]; other site 101510007568 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 101510007569 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 101510007570 active site 101510007571 FMN binding site [chemical binding]; other site 101510007572 substrate binding site [chemical binding]; other site 101510007573 3Fe-4S cluster binding site [ion binding]; other site 101510007574 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 101510007575 domain_subunit interface; other site 101510007576 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 101510007577 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 101510007578 active site 101510007579 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 101510007580 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 101510007581 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 101510007582 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 101510007583 hydroxyglutarate oxidase; Provisional; Region: PRK11728 101510007584 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 101510007585 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510007586 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510007587 FMN-binding pocket [chemical binding]; other site 101510007588 flavin binding motif; other site 101510007589 phosphate binding motif [ion binding]; other site 101510007590 beta-alpha-beta structure motif; other site 101510007591 NAD binding pocket [chemical binding]; other site 101510007592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510007593 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510007594 catalytic loop [active] 101510007595 iron binding site [ion binding]; other site 101510007596 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 101510007597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007598 HutD; Region: HutD; pfam05962 101510007599 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 101510007600 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510007601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510007602 non-specific DNA binding site [nucleotide binding]; other site 101510007603 salt bridge; other site 101510007604 sequence-specific DNA binding site [nucleotide binding]; other site 101510007605 Cupin domain; Region: Cupin_2; cl17218 101510007606 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510007607 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510007608 NAD(P) binding site [chemical binding]; other site 101510007609 catalytic residues [active] 101510007610 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 101510007611 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 101510007612 NAD binding site [chemical binding]; other site 101510007613 catalytic Zn binding site [ion binding]; other site 101510007614 substrate binding site [chemical binding]; other site 101510007615 structural Zn binding site [ion binding]; other site 101510007616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007617 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510007618 tyramine oxidase; Provisional; Region: tynA; PRK11504 101510007619 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 101510007620 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 101510007621 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 101510007622 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510007623 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510007624 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 101510007625 active site 101510007626 PAS domain; Region: PAS_9; pfam13426 101510007627 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 101510007628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 101510007629 putative active site [active] 101510007630 heme pocket [chemical binding]; other site 101510007631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510007632 ATP binding site [chemical binding]; other site 101510007633 Mg2+ binding site [ion binding]; other site 101510007634 G-X-G motif; other site 101510007635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510007636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007637 active site 101510007638 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510007639 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 101510007640 [2Fe-2S] cluster binding site [ion binding]; other site 101510007641 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 101510007642 putative alpha subunit interface [polypeptide binding]; other site 101510007643 putative active site [active] 101510007644 putative substrate binding site [chemical binding]; other site 101510007645 Fe binding site [ion binding]; other site 101510007646 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510007647 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510007648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510007649 NAD(P) binding site [chemical binding]; other site 101510007650 active site 101510007651 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510007652 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510007653 FMN-binding pocket [chemical binding]; other site 101510007654 flavin binding motif; other site 101510007655 phosphate binding motif [ion binding]; other site 101510007656 beta-alpha-beta structure motif; other site 101510007657 NAD binding pocket [chemical binding]; other site 101510007658 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510007659 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510007660 catalytic loop [active] 101510007661 iron binding site [ion binding]; other site 101510007662 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 101510007663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510007664 active site 101510007665 phosphorylation site [posttranslational modification] 101510007666 intermolecular recognition site; other site 101510007667 dimerization interface [polypeptide binding]; other site 101510007668 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510007669 DNA binding residues [nucleotide binding] 101510007670 dimerization interface [polypeptide binding]; other site 101510007671 Flavin Reductases; Region: FlaRed; cl00801 101510007672 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 101510007673 Na binding site [ion binding]; other site 101510007674 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 101510007675 Amidase; Region: Amidase; cl11426 101510007676 Amidase; Region: Amidase; cl11426 101510007677 Amidase; Region: Amidase; cl11426 101510007678 Cupin domain; Region: Cupin_2; cl17218 101510007679 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 101510007680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510007681 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510007682 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 101510007683 acyl-activating enzyme (AAE) consensus motif; other site 101510007684 AMP binding site [chemical binding]; other site 101510007685 active site 101510007686 CoA binding site [chemical binding]; other site 101510007687 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 101510007688 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 101510007689 FAD binding pocket [chemical binding]; other site 101510007690 FAD binding motif [chemical binding]; other site 101510007691 phosphate binding motif [ion binding]; other site 101510007692 beta-alpha-beta structure motif; other site 101510007693 NAD(p) ribose binding residues [chemical binding]; other site 101510007694 NAD binding pocket [chemical binding]; other site 101510007695 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 101510007696 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510007697 catalytic loop [active] 101510007698 iron binding site [ion binding]; other site 101510007699 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 101510007700 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 101510007701 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 101510007702 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 101510007703 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 101510007704 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 101510007705 enoyl-CoA hydratase; Provisional; Region: PRK08140 101510007706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510007707 substrate binding site [chemical binding]; other site 101510007708 oxyanion hole (OAH) forming residues; other site 101510007709 trimer interface [polypeptide binding]; other site 101510007710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 101510007711 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 101510007712 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510007713 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510007714 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510007715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510007716 substrate binding site [chemical binding]; other site 101510007717 oxyanion hole (OAH) forming residues; other site 101510007718 trimer interface [polypeptide binding]; other site 101510007719 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 101510007720 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510007721 dimer interface [polypeptide binding]; other site 101510007722 active site 101510007723 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 101510007724 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 101510007725 substrate binding site [chemical binding]; other site 101510007726 dimer interface [polypeptide binding]; other site 101510007727 NADP binding site [chemical binding]; other site 101510007728 catalytic residues [active] 101510007729 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510007730 active site 2 [active] 101510007731 active site 1 [active] 101510007732 conserved hypothetical protein; Region: TIGR02118 101510007733 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510007734 CoenzymeA binding site [chemical binding]; other site 101510007735 subunit interaction site [polypeptide binding]; other site 101510007736 PHB binding site; other site 101510007737 Part of AAA domain; Region: AAA_19; pfam13245 101510007738 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 101510007739 AAA domain; Region: AAA_12; pfam13087 101510007740 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 101510007741 putative active site [active] 101510007742 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 101510007743 putative FMN binding site [chemical binding]; other site 101510007744 Predicted transcriptional regulators [Transcription]; Region: COG1733 101510007745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510007746 putative Zn2+ binding site [ion binding]; other site 101510007747 putative DNA binding site [nucleotide binding]; other site 101510007748 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510007749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510007750 DNA-binding site [nucleotide binding]; DNA binding site 101510007751 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 101510007752 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510007753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007754 active site 101510007755 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 101510007756 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 101510007757 putative active site [active] 101510007758 putative catalytic site [active] 101510007759 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510007760 active site 2 [active] 101510007761 active site 1 [active] 101510007762 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 101510007763 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510007764 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510007765 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510007766 DNA binding site [nucleotide binding] 101510007767 domain linker motif; other site 101510007768 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 101510007769 putative dimerization interface [polypeptide binding]; other site 101510007770 putative ligand binding site [chemical binding]; other site 101510007771 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510007772 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 101510007773 inhibitor site; inhibition site 101510007774 active site 101510007775 dimer interface [polypeptide binding]; other site 101510007776 catalytic residue [active] 101510007777 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 101510007778 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 101510007779 YCII-related domain; Region: YCII; cl00999 101510007780 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510007781 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 101510007782 CGNR zinc finger; Region: zf-CGNR; pfam11706 101510007783 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510007784 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510007785 active site 101510007786 non-prolyl cis peptide bond; other site 101510007787 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 101510007788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007789 active site 101510007790 aromatic amino acid exporter; Provisional; Region: PRK11689 101510007791 EamA-like transporter family; Region: EamA; cl17759 101510007792 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 101510007793 active site 101510007794 cosubstrate binding site; other site 101510007795 substrate binding site [chemical binding]; other site 101510007796 catalytic site [active] 101510007797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007798 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 101510007799 putative substrate translocation pore; other site 101510007800 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510007801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510007802 DNA-binding site [nucleotide binding]; DNA binding site 101510007803 FCD domain; Region: FCD; pfam07729 101510007804 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 101510007805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510007806 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510007807 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 101510007808 inhibitor site; inhibition site 101510007809 active site 101510007810 dimer interface [polypeptide binding]; other site 101510007811 catalytic residue [active] 101510007812 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 101510007813 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 101510007814 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 101510007815 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 101510007816 tetrameric interface [polypeptide binding]; other site 101510007817 NAD binding site [chemical binding]; other site 101510007818 catalytic residues [active] 101510007819 substrate binding site [chemical binding]; other site 101510007820 Transcription factor WhiB; Region: Whib; pfam02467 101510007821 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510007822 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510007823 P-loop; other site 101510007824 Magnesium ion binding site [ion binding]; other site 101510007825 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510007826 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 101510007827 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 101510007828 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 101510007829 dimer interface [polypeptide binding]; other site 101510007830 NADP binding site [chemical binding]; other site 101510007831 catalytic residues [active] 101510007832 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 101510007833 tetramer (dimer of dimers) interface [polypeptide binding]; other site 101510007834 active site 101510007835 dimer interface [polypeptide binding]; other site 101510007836 phosphoglycolate phosphatase; Provisional; Region: PRK13222 101510007837 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 101510007838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510007839 active site 101510007840 motif I; other site 101510007841 motif II; other site 101510007842 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 101510007843 N- and C-terminal domain interface [polypeptide binding]; other site 101510007844 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 101510007845 active site 101510007846 MgATP binding site [chemical binding]; other site 101510007847 catalytic site [active] 101510007848 metal binding site [ion binding]; metal-binding site 101510007849 xylulose binding site [chemical binding]; other site 101510007850 homodimer interface [polypeptide binding]; other site 101510007851 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510007852 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 101510007853 NAD(P) binding site [chemical binding]; other site 101510007854 catalytic residues [active] 101510007855 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 101510007856 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 101510007857 ligand binding site [chemical binding]; other site 101510007858 NAD binding site [chemical binding]; other site 101510007859 catalytic site [active] 101510007860 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 101510007861 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510007862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510007863 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510007864 NAD(P) binding site [chemical binding]; other site 101510007865 active site 101510007866 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510007867 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510007868 TM-ABC transporter signature motif; other site 101510007869 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510007870 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510007871 Walker A/P-loop; other site 101510007872 ATP binding site [chemical binding]; other site 101510007873 Q-loop/lid; other site 101510007874 ABC transporter signature motif; other site 101510007875 Walker B; other site 101510007876 D-loop; other site 101510007877 H-loop/switch region; other site 101510007878 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510007879 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 101510007880 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510007881 ligand binding site [chemical binding]; other site 101510007882 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510007883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510007884 DNA-binding site [nucleotide binding]; DNA binding site 101510007885 FCD domain; Region: FCD; pfam07729 101510007886 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510007887 hydrophobic ligand binding site; other site 101510007888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510007889 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510007890 NAD(P) binding site [chemical binding]; other site 101510007891 active site 101510007892 FAD binding domain; Region: FAD_binding_2; pfam00890 101510007893 YCII-related domain; Region: YCII; cl00999 101510007894 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510007895 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510007896 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510007897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007898 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510007899 putative substrate translocation pore; other site 101510007900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510007901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510007902 short chain dehydrogenase; Provisional; Region: PRK05872 101510007903 classical (c) SDRs; Region: SDR_c; cd05233 101510007904 NAD(P) binding site [chemical binding]; other site 101510007905 active site 101510007906 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510007907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510007908 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 101510007909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510007910 ATP binding site [chemical binding]; other site 101510007911 Mg2+ binding site [ion binding]; other site 101510007912 G-X-G motif; other site 101510007913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510007914 active site 101510007915 phosphorylation site [posttranslational modification] 101510007916 intermolecular recognition site; other site 101510007917 benzoate transport; Region: 2A0115; TIGR00895 101510007918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007919 putative substrate translocation pore; other site 101510007920 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 101510007921 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 101510007922 metal binding site [ion binding]; metal-binding site 101510007923 putative dimer interface [polypeptide binding]; other site 101510007924 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 101510007925 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510007926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510007927 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 101510007928 lipoyl synthase; Provisional; Region: PRK05481 101510007929 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510007930 FeS/SAM binding site; other site 101510007931 glycine dehydrogenase; Provisional; Region: PRK05367 101510007932 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 101510007933 tetramer interface [polypeptide binding]; other site 101510007934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510007935 catalytic residue [active] 101510007936 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 101510007937 tetramer interface [polypeptide binding]; other site 101510007938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510007939 catalytic residue [active] 101510007940 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 101510007941 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 101510007942 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 101510007943 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 101510007944 lipoyl attachment site [posttranslational modification]; other site 101510007945 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 101510007946 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 101510007947 dimer interface [polypeptide binding]; other site 101510007948 active site 101510007949 glycine-pyridoxal phosphate binding site [chemical binding]; other site 101510007950 folate binding site [chemical binding]; other site 101510007951 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 101510007952 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 101510007953 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 101510007954 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 101510007955 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510007956 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510007957 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510007958 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510007959 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 101510007960 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 101510007961 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510007962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510007963 DNA-binding site [nucleotide binding]; DNA binding site 101510007964 FCD domain; Region: FCD; pfam07729 101510007965 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510007966 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510007967 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510007968 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510007969 active site 101510007970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510007971 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510007972 putative substrate translocation pore; other site 101510007973 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 101510007974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510007975 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510007976 dimerization interface [polypeptide binding]; other site 101510007977 substrate binding pocket [chemical binding]; other site 101510007978 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 101510007979 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 101510007980 Aspartase; Region: Aspartase; cd01357 101510007981 active sites [active] 101510007982 tetramer interface [polypeptide binding]; other site 101510007983 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 101510007984 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 101510007985 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510007986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510007987 DNA-binding site [nucleotide binding]; DNA binding site 101510007988 FCD domain; Region: FCD; pfam07729 101510007989 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 101510007990 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 101510007991 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 101510007992 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 101510007993 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510007994 Cytochrome P450; Region: p450; cl12078 101510007995 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510007996 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510007997 FMN-binding pocket [chemical binding]; other site 101510007998 flavin binding motif; other site 101510007999 phosphate binding motif [ion binding]; other site 101510008000 beta-alpha-beta structure motif; other site 101510008001 NAD binding pocket [chemical binding]; other site 101510008002 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510008003 catalytic loop [active] 101510008004 iron binding site [ion binding]; other site 101510008005 tetracycline repressor protein TetR; Provisional; Region: PRK13756 101510008006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008007 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510008008 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510008009 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 101510008010 putative NAD(P) binding site [chemical binding]; other site 101510008011 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510008012 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510008013 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510008014 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 101510008015 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 101510008016 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 101510008017 Walker A/P-loop; other site 101510008018 ATP binding site [chemical binding]; other site 101510008019 Q-loop/lid; other site 101510008020 ABC transporter signature motif; other site 101510008021 Walker B; other site 101510008022 D-loop; other site 101510008023 H-loop/switch region; other site 101510008024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008026 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 101510008027 putative hydrophobic ligand binding site [chemical binding]; other site 101510008028 Glutaminase; Region: Glutaminase; cl00907 101510008029 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510008030 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510008031 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 101510008032 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 101510008033 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 101510008034 homodimer interface [polypeptide binding]; other site 101510008035 substrate-cofactor binding pocket; other site 101510008036 catalytic residue [active] 101510008037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 101510008038 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 101510008039 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 101510008040 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 101510008041 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 101510008042 active site 101510008043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510008044 Coenzyme A binding pocket [chemical binding]; other site 101510008045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 101510008046 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 101510008047 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 101510008048 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 101510008049 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510008050 active site 2 [active] 101510008051 active site 1 [active] 101510008052 amidase; Provisional; Region: PRK07486 101510008053 Amidase; Region: Amidase; pfam01425 101510008054 FAD binding domain; Region: FAD_binding_4; pfam01565 101510008055 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 101510008056 benzoylformate decarboxylase; Reviewed; Region: PRK07092 101510008057 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510008058 PYR/PP interface [polypeptide binding]; other site 101510008059 dimer interface [polypeptide binding]; other site 101510008060 TPP binding site [chemical binding]; other site 101510008061 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510008062 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 101510008063 TPP-binding site [chemical binding]; other site 101510008064 dimer interface [polypeptide binding]; other site 101510008065 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510008066 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 101510008067 NAD(P) binding site [chemical binding]; other site 101510008068 catalytic residues [active] 101510008069 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510008070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510008071 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 101510008072 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 101510008073 active site 101510008074 substrate binding site [chemical binding]; other site 101510008075 FMN binding site [chemical binding]; other site 101510008076 putative catalytic residues [active] 101510008077 benzoate transport; Region: 2A0115; TIGR00895 101510008078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008079 putative substrate translocation pore; other site 101510008080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510008081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510008082 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 101510008083 substrate binding pocket [chemical binding]; other site 101510008084 dimerization interface [polypeptide binding]; other site 101510008085 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510008086 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510008087 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510008088 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 101510008089 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510008090 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510008091 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510008092 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510008093 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 101510008094 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510008095 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510008096 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510008097 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510008098 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 101510008099 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 101510008100 active site 101510008101 dimer interface [polypeptide binding]; other site 101510008102 metal binding site [ion binding]; metal-binding site 101510008103 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 101510008104 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 101510008105 active site 101510008106 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 101510008107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008108 putative substrate translocation pore; other site 101510008109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008110 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510008111 Ligand Binding Site [chemical binding]; other site 101510008112 RNB domain; Region: RNB; pfam00773 101510008113 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510008114 active site 101510008115 DNA binding site [nucleotide binding] 101510008116 Int/Topo IB signature motif; other site 101510008117 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510008118 DNA binding site [nucleotide binding] 101510008119 active site 101510008120 Int/Topo IB signature motif; other site 101510008121 catalytic residues [active] 101510008122 lipid-transfer protein; Provisional; Region: PRK08256 101510008123 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510008124 active site 101510008125 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 101510008126 active site 101510008127 catalytic site [active] 101510008128 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510008129 active site 2 [active] 101510008130 active site 1 [active] 101510008131 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510008132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510008133 NAD(P) binding site [chemical binding]; other site 101510008134 active site 101510008135 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510008136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510008137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510008138 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510008139 acyl-activating enzyme (AAE) consensus motif; other site 101510008140 acyl-activating enzyme (AAE) consensus motif; other site 101510008141 putative AMP binding site [chemical binding]; other site 101510008142 putative active site [active] 101510008143 putative CoA binding site [chemical binding]; other site 101510008144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008147 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 101510008148 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 101510008149 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510008150 Ligand Binding Site [chemical binding]; other site 101510008151 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510008152 Spore germination protein; Region: Spore_permease; cl17796 101510008153 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510008154 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 101510008155 putative active site [active] 101510008156 catalytic triad [active] 101510008157 putative dimer interface [polypeptide binding]; other site 101510008158 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 101510008159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510008160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510008161 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 101510008162 DNA-binding site [nucleotide binding]; DNA binding site 101510008163 FCD domain; Region: FCD; pfam07729 101510008164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008165 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510008166 putative substrate translocation pore; other site 101510008167 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 101510008168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510008169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510008170 active site 101510008171 ATP binding site [chemical binding]; other site 101510008172 substrate binding site [chemical binding]; other site 101510008173 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510008174 substrate binding site [chemical binding]; other site 101510008175 activation loop (A-loop); other site 101510008176 activation loop (A-loop); other site 101510008177 AAA ATPase domain; Region: AAA_16; pfam13191 101510008178 Predicted ATPase [General function prediction only]; Region: COG3903 101510008179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 101510008180 TPR motif; other site 101510008181 binding surface 101510008182 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510008183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510008184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510008185 DNA binding residues [nucleotide binding] 101510008186 dimerization interface [polypeptide binding]; other site 101510008187 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510008188 MarR family; Region: MarR_2; pfam12802 101510008189 MarR family; Region: MarR_2; cl17246 101510008190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008192 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 101510008193 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510008194 dimer interface [polypeptide binding]; other site 101510008195 active site 101510008196 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 101510008197 putative active site [active] 101510008198 putative catalytic site [active] 101510008199 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 101510008200 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510008201 dimer interface [polypeptide binding]; other site 101510008202 active site 101510008203 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510008204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510008205 active site 101510008206 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510008207 CoA binding site [chemical binding]; other site 101510008208 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510008209 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510008210 active site 101510008211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510008212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510008213 NAD(P) binding site [chemical binding]; other site 101510008214 active site 101510008215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510008216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510008217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 101510008218 dimerization interface [polypeptide binding]; other site 101510008219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510008220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510008221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 101510008222 dimerization interface [polypeptide binding]; other site 101510008223 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510008224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510008225 DNA-binding site [nucleotide binding]; DNA binding site 101510008226 FCD domain; Region: FCD; pfam07729 101510008227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008229 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510008230 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510008231 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510008232 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 101510008233 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 101510008234 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 101510008235 putative molybdopterin cofactor binding site [chemical binding]; other site 101510008236 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 101510008237 putative molybdopterin cofactor binding site; other site 101510008238 hypothetical protein; Provisional; Region: PRK06184 101510008239 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510008240 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 101510008241 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 101510008242 dimer interface [polypeptide binding]; other site 101510008243 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 101510008244 active site 101510008245 Fe binding site [ion binding]; other site 101510008246 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 101510008247 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 101510008248 putative DNA binding site [nucleotide binding]; other site 101510008249 putative Zn2+ binding site [ion binding]; other site 101510008250 AsnC family; Region: AsnC_trans_reg; pfam01037 101510008251 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 101510008252 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 101510008253 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 101510008254 NAD(P) binding pocket [chemical binding]; other site 101510008255 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510008256 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510008257 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 101510008258 active site 101510008259 FMN binding site [chemical binding]; other site 101510008260 substrate binding site [chemical binding]; other site 101510008261 putative catalytic residue [active] 101510008262 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 101510008263 putative hydrophobic ligand binding site [chemical binding]; other site 101510008264 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510008265 putative DNA binding site [nucleotide binding]; other site 101510008266 putative Zn2+ binding site [ion binding]; other site 101510008267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008269 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510008270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008271 putative substrate translocation pore; other site 101510008272 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510008273 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510008274 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510008275 Dehydroquinase class II; Region: DHquinase_II; pfam01220 101510008276 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 101510008277 trimer interface [polypeptide binding]; other site 101510008278 active site 101510008279 dimer interface [polypeptide binding]; other site 101510008280 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 101510008281 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 101510008282 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510008283 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510008284 active site 101510008285 ATP binding site [chemical binding]; other site 101510008286 substrate binding site [chemical binding]; other site 101510008287 activation loop (A-loop); other site 101510008288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008290 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 101510008291 Protein of unknown function (DUF664); Region: DUF664; pfam04978 101510008292 DinB superfamily; Region: DinB_2; pfam12867 101510008293 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510008294 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510008295 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510008296 active site 101510008297 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510008298 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 101510008299 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510008300 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510008301 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 101510008302 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 101510008303 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 101510008304 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510008305 NAD binding site [chemical binding]; other site 101510008306 catalytic residues [active] 101510008307 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510008308 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510008309 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 101510008310 enoyl-CoA hydratase; Provisional; Region: PRK09245 101510008311 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510008312 substrate binding site [chemical binding]; other site 101510008313 oxyanion hole (OAH) forming residues; other site 101510008314 trimer interface [polypeptide binding]; other site 101510008315 Uncharacterized conserved protein [Function unknown]; Region: COG3391 101510008316 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 101510008317 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 101510008318 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 101510008319 Chromate transporter; Region: Chromate_transp; pfam02417 101510008320 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510008321 Cytochrome P450; Region: p450; cl12078 101510008322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008323 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510008324 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510008325 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 101510008326 NAD(P) binding site [chemical binding]; other site 101510008327 catalytic residues [active] 101510008328 short chain dehydrogenase; Provisional; Region: PRK07825 101510008329 classical (c) SDRs; Region: SDR_c; cd05233 101510008330 NAD(P) binding site [chemical binding]; other site 101510008331 active site 101510008332 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 101510008333 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 101510008334 NAD binding site [chemical binding]; other site 101510008335 catalytic Zn binding site [ion binding]; other site 101510008336 structural Zn binding site [ion binding]; other site 101510008337 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 101510008338 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510008339 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510008340 DNA binding residues [nucleotide binding] 101510008341 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510008342 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510008343 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510008344 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 101510008345 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 101510008346 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 101510008347 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510008348 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510008349 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510008350 active site 101510008351 short chain dehydrogenase; Provisional; Region: PRK08251 101510008352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510008353 NAD(P) binding site [chemical binding]; other site 101510008354 active site 101510008355 Phosphotransferase enzyme family; Region: APH; pfam01636 101510008356 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510008357 putative active site [active] 101510008358 putative substrate binding site [chemical binding]; other site 101510008359 ATP binding site [chemical binding]; other site 101510008360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008362 WHG domain; Region: WHG; pfam13305 101510008363 Uncharacterized conserved protein [Function unknown]; Region: COG3268 101510008364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510008365 NAD(P) binding site [chemical binding]; other site 101510008366 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 101510008367 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 101510008368 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510008369 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510008370 substrate binding pocket [chemical binding]; other site 101510008371 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510008372 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 101510008373 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 101510008374 NAD(P) binding site [chemical binding]; other site 101510008375 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 101510008376 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 101510008377 NAD(P) binding site [chemical binding]; other site 101510008378 catalytic residues [active] 101510008379 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 101510008380 WHG domain; Region: WHG; pfam13305 101510008381 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510008382 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 101510008383 putative active site [active] 101510008384 putative FMN binding site [chemical binding]; other site 101510008385 putative substrate binding site [chemical binding]; other site 101510008386 putative catalytic residue [active] 101510008387 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 101510008388 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 101510008389 potential catalytic triad [active] 101510008390 conserved cys residue [active] 101510008391 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510008392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008393 putative substrate translocation pore; other site 101510008394 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510008395 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 101510008396 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510008397 catalytic residues [active] 101510008398 catalytic nucleophile [active] 101510008399 Presynaptic Site I dimer interface [polypeptide binding]; other site 101510008400 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 101510008401 Synaptic Flat tetramer interface [polypeptide binding]; other site 101510008402 Synaptic Site I dimer interface [polypeptide binding]; other site 101510008403 DNA binding site [nucleotide binding] 101510008404 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 101510008405 DNA-binding interface [nucleotide binding]; DNA binding site 101510008406 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 101510008407 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 101510008408 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510008409 catalytic residues [active] 101510008410 catalytic nucleophile [active] 101510008411 Presynaptic Site I dimer interface [polypeptide binding]; other site 101510008412 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 101510008413 Synaptic Flat tetramer interface [polypeptide binding]; other site 101510008414 Synaptic Site I dimer interface [polypeptide binding]; other site 101510008415 DNA binding site [nucleotide binding] 101510008416 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 101510008417 DNA-binding interface [nucleotide binding]; DNA binding site 101510008418 Fic/DOC family; Region: Fic; cl00960 101510008419 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 101510008420 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 101510008421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 101510008422 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510008423 active site 101510008424 catalytic residues [active] 101510008425 DNA binding site [nucleotide binding] 101510008426 Int/Topo IB signature motif; other site 101510008427 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 101510008428 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510008429 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510008430 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510008431 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510008432 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510008433 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 101510008434 Walker A/P-loop; other site 101510008435 ATP binding site [chemical binding]; other site 101510008436 Q-loop/lid; other site 101510008437 ABC transporter signature motif; other site 101510008438 Walker B; other site 101510008439 D-loop; other site 101510008440 H-loop/switch region; other site 101510008441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510008442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510008443 Walker A/P-loop; other site 101510008444 ATP binding site [chemical binding]; other site 101510008445 Q-loop/lid; other site 101510008446 ABC transporter signature motif; other site 101510008447 Walker B; other site 101510008448 D-loop; other site 101510008449 H-loop/switch region; other site 101510008450 MspA; Region: MspA; pfam09203 101510008451 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 101510008452 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 101510008453 active site 101510008454 catalytic site [active] 101510008455 NodB motif; other site 101510008456 metal binding site [ion binding]; metal-binding site 101510008457 Predicted esterase [General function prediction only]; Region: COG0627 101510008458 hypothetical protein; Provisional; Region: PRK13685 101510008459 Aerotolerance regulator N-terminal; Region: BatA; cl06567 101510008460 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 101510008461 metal ion-dependent adhesion site (MIDAS); other site 101510008462 Interferon-induced transmembrane protein; Region: CD225; pfam04505 101510008463 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 101510008464 active site 101510008465 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 101510008466 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 101510008467 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510008468 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510008469 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510008470 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510008471 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 101510008472 active site 101510008473 catalytic triad [active] 101510008474 oxyanion hole [active] 101510008475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510008476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510008477 dimerization interface [polypeptide binding]; other site 101510008478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510008479 dimer interface [polypeptide binding]; other site 101510008480 phosphorylation site [posttranslational modification] 101510008481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510008482 ATP binding site [chemical binding]; other site 101510008483 Mg2+ binding site [ion binding]; other site 101510008484 G-X-G motif; other site 101510008485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510008486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510008487 active site 101510008488 phosphorylation site [posttranslational modification] 101510008489 intermolecular recognition site; other site 101510008490 dimerization interface [polypeptide binding]; other site 101510008491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510008492 DNA binding site [nucleotide binding] 101510008493 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 101510008494 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 101510008495 Walker A/P-loop; other site 101510008496 ATP binding site [chemical binding]; other site 101510008497 Q-loop/lid; other site 101510008498 ABC transporter signature motif; other site 101510008499 Walker B; other site 101510008500 D-loop; other site 101510008501 H-loop/switch region; other site 101510008502 TOBE domain; Region: TOBE_2; pfam08402 101510008503 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 101510008504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510008505 ABC-ATPase subunit interface; other site 101510008506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510008507 dimer interface [polypeptide binding]; other site 101510008508 conserved gate region; other site 101510008509 putative PBP binding loops; other site 101510008510 ABC-ATPase subunit interface; other site 101510008511 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 101510008512 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 101510008513 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 101510008514 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510008515 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 101510008516 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 101510008517 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 101510008518 putative active site; other site 101510008519 putative metal binding residues [ion binding]; other site 101510008520 signature motif; other site 101510008521 putative triphosphate binding site [ion binding]; other site 101510008522 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 101510008523 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 101510008524 MspA; Region: MspA; pfam09203 101510008525 multiple promoter invertase; Provisional; Region: mpi; PRK13413 101510008526 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510008527 catalytic residues [active] 101510008528 catalytic nucleophile [active] 101510008529 Presynaptic Site I dimer interface [polypeptide binding]; other site 101510008530 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 101510008531 Synaptic Flat tetramer interface [polypeptide binding]; other site 101510008532 Synaptic Site I dimer interface [polypeptide binding]; other site 101510008533 DNA binding site [nucleotide binding] 101510008534 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 101510008535 DNA-binding interface [nucleotide binding]; DNA binding site 101510008536 Transposase [DNA replication, recombination, and repair]; Region: COG5421 101510008537 Protein of unknown function DUF262; Region: DUF262; pfam03235 101510008538 Uncharacterized conserved protein [Function unknown]; Region: COG1479 101510008539 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 101510008540 multiple promoter invertase; Provisional; Region: mpi; PRK13413 101510008541 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510008542 catalytic residues [active] 101510008543 catalytic nucleophile [active] 101510008544 Presynaptic Site I dimer interface [polypeptide binding]; other site 101510008545 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 101510008546 Synaptic Flat tetramer interface [polypeptide binding]; other site 101510008547 Synaptic Site I dimer interface [polypeptide binding]; other site 101510008548 DNA binding site [nucleotide binding] 101510008549 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 101510008550 DNA-binding interface [nucleotide binding]; DNA binding site 101510008551 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510008552 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 101510008553 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 101510008554 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 101510008555 NAD binding site [chemical binding]; other site 101510008556 Phe binding site; other site 101510008557 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510008558 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 101510008559 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 101510008560 dimer interface [polypeptide binding]; other site 101510008561 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 101510008562 active site 101510008563 Fe binding site [ion binding]; other site 101510008564 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 101510008565 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 101510008566 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 101510008567 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510008568 active site 101510008569 DNA binding site [nucleotide binding] 101510008570 Int/Topo IB signature motif; other site 101510008571 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 101510008572 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 101510008573 catalytic residues [active] 101510008574 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510008575 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510008576 active site 101510008577 ATP binding site [chemical binding]; other site 101510008578 substrate binding site [chemical binding]; other site 101510008579 activation loop (A-loop); other site 101510008580 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510008581 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510008582 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510008583 phosphopeptide binding site; other site 101510008584 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510008585 Helix-turn-helix domain; Region: HTH_36; pfam13730 101510008586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510008587 dimerization interface [polypeptide binding]; other site 101510008588 DNA binding residues [nucleotide binding] 101510008589 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 101510008590 multiple promoter invertase; Provisional; Region: mpi; PRK13413 101510008591 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510008592 catalytic residues [active] 101510008593 catalytic nucleophile [active] 101510008594 Presynaptic Site I dimer interface [polypeptide binding]; other site 101510008595 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 101510008596 Synaptic Flat tetramer interface [polypeptide binding]; other site 101510008597 Synaptic Site I dimer interface [polypeptide binding]; other site 101510008598 DNA binding site [nucleotide binding] 101510008599 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 101510008600 DNA-binding interface [nucleotide binding]; DNA binding site 101510008601 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 101510008602 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510008603 active site 101510008604 catalytic residues [active] 101510008605 DNA binding site [nucleotide binding] 101510008606 Int/Topo IB signature motif; other site 101510008607 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 101510008608 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 101510008609 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510008610 active site 101510008611 catalytic residues [active] 101510008612 DNA binding site [nucleotide binding] 101510008613 Int/Topo IB signature motif; other site 101510008614 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 101510008615 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510008616 DNA binding site [nucleotide binding] 101510008617 active site 101510008618 Int/Topo IB signature motif; other site 101510008619 catalytic residues [active] 101510008620 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510008621 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510008622 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 101510008623 active site 101510008624 FMN binding site [chemical binding]; other site 101510008625 substrate binding site [chemical binding]; other site 101510008626 putative catalytic residue [active] 101510008627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510008628 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 101510008629 active site 101510008630 catalytic site [active] 101510008631 Zn binding site [ion binding]; other site 101510008632 tetramer interface [polypeptide binding]; other site 101510008633 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 101510008634 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 101510008635 active site 101510008636 homodimer interface [polypeptide binding]; other site 101510008637 homotetramer interface [polypeptide binding]; other site 101510008638 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510008639 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510008640 DNA binding site [nucleotide binding] 101510008641 domain linker motif; other site 101510008642 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 101510008643 putative dimerization interface [polypeptide binding]; other site 101510008644 putative ligand binding site [chemical binding]; other site 101510008645 putative amidase; Provisional; Region: PRK06169 101510008646 Amidase; Region: Amidase; pfam01425 101510008647 Putative cyclase; Region: Cyclase; pfam04199 101510008648 classical (c) SDRs; Region: SDR_c; cd05233 101510008649 NAD(P) binding site [chemical binding]; other site 101510008650 active site 101510008651 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510008652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510008653 NAD(P) binding site [chemical binding]; other site 101510008654 active site 101510008655 benzoate transport; Region: 2A0115; TIGR00895 101510008656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008657 putative substrate translocation pore; other site 101510008658 Transcription factor WhiB; Region: Whib; pfam02467 101510008659 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510008660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510008661 putative DNA binding site [nucleotide binding]; other site 101510008662 putative Zn2+ binding site [ion binding]; other site 101510008663 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510008664 pyruvate kinase; Provisional; Region: PRK06247 101510008665 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 101510008666 domain interfaces; other site 101510008667 active site 101510008668 glyoxylate carboligase; Provisional; Region: PRK11269 101510008669 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510008670 PYR/PP interface [polypeptide binding]; other site 101510008671 dimer interface [polypeptide binding]; other site 101510008672 TPP binding site [chemical binding]; other site 101510008673 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510008674 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 101510008675 TPP-binding site [chemical binding]; other site 101510008676 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 101510008677 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510008678 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 101510008679 FAD binding domain; Region: FAD_binding_4; pfam01565 101510008680 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 101510008681 L-lactate permease; Region: Lactate_perm; cl00701 101510008682 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 101510008683 Transcription factor WhiB; Region: Whib; pfam02467 101510008684 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510008685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510008686 DNA-binding site [nucleotide binding]; DNA binding site 101510008687 FCD domain; Region: FCD; pfam07729 101510008688 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510008689 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510008690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510008691 DNA-binding site [nucleotide binding]; DNA binding site 101510008692 FCD domain; Region: FCD; pfam07729 101510008693 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 101510008694 L-lactate permease; Region: Lactate_perm; cl00701 101510008695 FAD binding domain; Region: FAD_binding_4; pfam01565 101510008696 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 101510008697 Predicted ATPase [General function prediction only]; Region: COG3903 101510008698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510008699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510008700 DNA binding residues [nucleotide binding] 101510008701 dimerization interface [polypeptide binding]; other site 101510008702 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510008703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510008706 enoyl-CoA hydratase; Provisional; Region: PRK06495 101510008707 substrate binding site [chemical binding]; other site 101510008708 oxyanion hole (OAH) forming residues; other site 101510008709 trimer interface [polypeptide binding]; other site 101510008710 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510008711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510008712 active site 101510008713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510008714 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510008715 active site 101510008716 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 101510008717 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 101510008718 acyl-activating enzyme (AAE) consensus motif; other site 101510008719 putative AMP binding site [chemical binding]; other site 101510008720 putative active site [active] 101510008721 putative CoA binding site [chemical binding]; other site 101510008722 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510008723 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510008724 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 101510008725 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 101510008726 Integrase core domain; Region: rve; pfam00665 101510008727 Transcription factor WhiB; Region: Whib; pfam02467 101510008728 Uncharacterized conserved protein [Function unknown]; Region: COG3391 101510008729 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 101510008730 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 101510008731 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 101510008732 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 101510008733 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 101510008734 Uncharacterized conserved protein [Function unknown]; Region: COG3391 101510008735 structural tetrad; other site 101510008736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510008737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510008738 DNA binding residues [nucleotide binding] 101510008739 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510008740 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510008741 DNA binding residues [nucleotide binding] 101510008742 Transcription factor WhiB; Region: Whib; pfam02467 101510008743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510008744 Uncharacterized conserved protein [Function unknown]; Region: COG5649 101510008745 MMPL family; Region: MMPL; pfam03176 101510008746 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510008747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510008748 putative Zn2+ binding site [ion binding]; other site 101510008749 putative DNA binding site [nucleotide binding]; other site 101510008750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 101510008751 binding surface 101510008752 TPR motif; other site 101510008753 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510008754 peroxiredoxin; Region: AhpC; TIGR03137 101510008755 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 101510008756 dimer interface [polypeptide binding]; other site 101510008757 decamer (pentamer of dimers) interface [polypeptide binding]; other site 101510008758 catalytic triad [active] 101510008759 peroxidatic and resolving cysteines [active] 101510008760 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 101510008761 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 101510008762 catalytic residue [active] 101510008763 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 101510008764 catalytic residues [active] 101510008765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510008766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510008767 CHAT domain; Region: CHAT; cl17868 101510008768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510008769 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 101510008770 dimer interface [polypeptide binding]; other site 101510008771 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510008772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510008773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008774 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510008775 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 101510008776 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510008777 NAD binding site [chemical binding]; other site 101510008778 catalytic Zn binding site [ion binding]; other site 101510008779 structural Zn binding site [ion binding]; other site 101510008780 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510008781 FAD binding domain; Region: FAD_binding_4; pfam01565 101510008782 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510008783 MarR family; Region: MarR_2; pfam12802 101510008784 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510008785 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510008786 NAD(P) binding site [chemical binding]; other site 101510008787 catalytic residues [active] 101510008788 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 101510008789 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 101510008790 catalytic Zn binding site [ion binding]; other site 101510008791 NAD binding site [chemical binding]; other site 101510008792 structural Zn binding site [ion binding]; other site 101510008793 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510008794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510008795 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 101510008796 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 101510008797 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 101510008798 aspartate aminotransferase; Provisional; Region: PRK06107 101510008799 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510008800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510008801 homodimer interface [polypeptide binding]; other site 101510008802 catalytic residue [active] 101510008803 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 101510008804 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 101510008805 putative NAD(P) binding site [chemical binding]; other site 101510008806 catalytic Zn binding site [ion binding]; other site 101510008807 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 101510008808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510008809 NAD(P) binding site [chemical binding]; other site 101510008810 active site 101510008811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510008812 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510008813 putative substrate translocation pore; other site 101510008814 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 101510008815 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 101510008816 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 101510008817 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 101510008818 putative active site [active] 101510008819 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 101510008820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510008821 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 101510008822 putative dimerization interface [polypeptide binding]; other site 101510008823 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 101510008824 putative ligand binding site [chemical binding]; other site 101510008825 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 101510008826 putative NAD binding site [chemical binding]; other site 101510008827 catalytic site [active] 101510008828 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 101510008829 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 101510008830 NADP binding site [chemical binding]; other site 101510008831 homodimer interface [polypeptide binding]; other site 101510008832 active site 101510008833 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 101510008834 AAA domain; Region: AAA_33; pfam13671 101510008835 ATP-binding site [chemical binding]; other site 101510008836 Gluconate-6-phosphate binding site [chemical binding]; other site 101510008837 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 101510008838 tetramer interface [polypeptide binding]; other site 101510008839 TPP-binding site [chemical binding]; other site 101510008840 heterodimer interface [polypeptide binding]; other site 101510008841 phosphorylation loop region [posttranslational modification] 101510008842 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 101510008843 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 101510008844 PYR/PP interface [polypeptide binding]; other site 101510008845 dimer interface [polypeptide binding]; other site 101510008846 TPP binding site [chemical binding]; other site 101510008847 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510008848 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 101510008849 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 101510008850 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 101510008851 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510008852 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 101510008853 putative active site [active] 101510008854 catalytic residue [active] 101510008855 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 101510008856 TPP-binding site [chemical binding]; other site 101510008857 PYR/PP interface [polypeptide binding]; other site 101510008858 dimer interface [polypeptide binding]; other site 101510008859 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 101510008860 TPP binding site [chemical binding]; other site 101510008861 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510008862 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 101510008863 Sulfatase; Region: Sulfatase; pfam00884 101510008864 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 101510008865 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 101510008866 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 101510008867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510008868 dimer interface [polypeptide binding]; other site 101510008869 conserved gate region; other site 101510008870 ABC-ATPase subunit interface; other site 101510008871 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 101510008872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510008873 dimer interface [polypeptide binding]; other site 101510008874 conserved gate region; other site 101510008875 putative PBP binding loops; other site 101510008876 ABC-ATPase subunit interface; other site 101510008877 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 101510008878 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510008879 Walker A/P-loop; other site 101510008880 ATP binding site [chemical binding]; other site 101510008881 Q-loop/lid; other site 101510008882 ABC transporter signature motif; other site 101510008883 Walker B; other site 101510008884 D-loop; other site 101510008885 H-loop/switch region; other site 101510008886 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510008887 Walker A/P-loop; other site 101510008888 ATP binding site [chemical binding]; other site 101510008889 Q-loop/lid; other site 101510008890 ABC transporter signature motif; other site 101510008891 Walker B; other site 101510008892 D-loop; other site 101510008893 H-loop/switch region; other site 101510008894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510008895 Predicted membrane protein [Function unknown]; Region: COG4129 101510008896 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 101510008897 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510008898 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 101510008899 active site 101510008900 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 101510008901 active site 101510008902 NTP binding site [chemical binding]; other site 101510008903 metal binding triad [ion binding]; metal-binding site 101510008904 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 101510008905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510008906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510008907 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 101510008908 Probable transposase; Region: OrfB_IS605; pfam01385 101510008909 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 101510008910 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 101510008911 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 101510008912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510008913 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 101510008914 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 101510008915 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 101510008916 E3 interaction surface; other site 101510008917 lipoyl attachment site [posttranslational modification]; other site 101510008918 e3 binding domain; Region: E3_binding; pfam02817 101510008919 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 101510008920 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 101510008921 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 101510008922 alpha subunit interface [polypeptide binding]; other site 101510008923 TPP binding site [chemical binding]; other site 101510008924 heterodimer interface [polypeptide binding]; other site 101510008925 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510008926 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 101510008927 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 101510008928 tetramer interface [polypeptide binding]; other site 101510008929 TPP-binding site [chemical binding]; other site 101510008930 heterodimer interface [polypeptide binding]; other site 101510008931 phosphorylation loop region [posttranslational modification] 101510008932 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510008933 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 101510008934 putative DNA binding site [nucleotide binding]; other site 101510008935 putative Zn2+ binding site [ion binding]; other site 101510008936 AsnC family; Region: AsnC_trans_reg; pfam01037 101510008937 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 101510008938 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 101510008939 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 101510008940 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 101510008941 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 101510008942 Domain of unknown function DUF21; Region: DUF21; pfam01595 101510008943 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 101510008944 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 101510008945 Domain of unknown function DUF21; Region: DUF21; pfam01595 101510008946 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 101510008947 Transporter associated domain; Region: CorC_HlyC; pfam03471 101510008948 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 101510008949 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 101510008950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510008951 FeS/SAM binding site; other site 101510008952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510008953 Coenzyme A binding pocket [chemical binding]; other site 101510008954 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 101510008955 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 101510008956 dimerization interface [polypeptide binding]; other site 101510008957 putative ATP binding site [chemical binding]; other site 101510008958 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 101510008959 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510008960 active site 101510008961 catalytic triad [active] 101510008962 dimer interface [polypeptide binding]; other site 101510008963 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 101510008964 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 101510008965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510008966 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 101510008967 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510008968 active site 101510008969 catalytic triad [active] 101510008970 dimer interface [polypeptide binding]; other site 101510008971 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 101510008972 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510008973 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510008974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510008975 putative DNA binding site [nucleotide binding]; other site 101510008976 putative Zn2+ binding site [ion binding]; other site 101510008977 AsnC family; Region: AsnC_trans_reg; pfam01037 101510008978 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 101510008979 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 101510008980 glycogen branching enzyme; Provisional; Region: PRK14705 101510008981 tetracycline repressor protein TetR; Provisional; Region: PRK13756 101510008982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510008983 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510008984 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 101510008985 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 101510008986 putative di-iron ligands [ion binding]; other site 101510008987 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 101510008988 Transcription factor WhiB; Region: Whib; pfam02467 101510008989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510008990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510008991 active site 101510008992 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510008993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510008994 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 101510008995 putative dimerization interface [polypeptide binding]; other site 101510008996 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 101510008997 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510008998 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510008999 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510009000 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 101510009001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510009002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510009003 dimer interface [polypeptide binding]; other site 101510009004 phosphorylation site [posttranslational modification] 101510009005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510009006 ATP binding site [chemical binding]; other site 101510009007 Mg2+ binding site [ion binding]; other site 101510009008 G-X-G motif; other site 101510009009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510009010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510009011 active site 101510009012 phosphorylation site [posttranslational modification] 101510009013 intermolecular recognition site; other site 101510009014 dimerization interface [polypeptide binding]; other site 101510009015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510009016 DNA binding site [nucleotide binding] 101510009017 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 101510009018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510009019 putative substrate translocation pore; other site 101510009020 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510009021 PYR/PP interface [polypeptide binding]; other site 101510009022 dimer interface [polypeptide binding]; other site 101510009023 TPP binding site [chemical binding]; other site 101510009024 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 101510009025 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 101510009026 TPP-binding site [chemical binding]; other site 101510009027 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510009028 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510009029 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510009030 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510009031 NAD(P) binding site [chemical binding]; other site 101510009032 catalytic residues [active] 101510009033 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 101510009034 putative RNAase interaction site [polypeptide binding]; other site 101510009035 Transcription factor WhiB; Region: Whib; pfam02467 101510009036 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 101510009037 putative active site; other site 101510009038 putative metal binding residues [ion binding]; other site 101510009039 signature motif; other site 101510009040 putative triphosphate binding site [ion binding]; other site 101510009041 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 101510009042 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510009043 catalytic core [active] 101510009044 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510009045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510009046 dimerization interface [polypeptide binding]; other site 101510009047 putative DNA binding site [nucleotide binding]; other site 101510009048 putative Zn2+ binding site [ion binding]; other site 101510009049 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 101510009050 arsenical-resistance protein; Region: acr3; TIGR00832 101510009051 Low molecular weight phosphatase family; Region: LMWPc; cd00115 101510009052 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 101510009053 active site 101510009054 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510009055 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510009056 active site 101510009057 ATP binding site [chemical binding]; other site 101510009058 substrate binding site [chemical binding]; other site 101510009059 activation loop (A-loop); other site 101510009060 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510009061 Predicted ATPase [General function prediction only]; Region: COG3903 101510009062 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510009063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510009064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510009065 DNA binding residues [nucleotide binding] 101510009066 dimerization interface [polypeptide binding]; other site 101510009067 Epoxide hydrolase N terminus; Region: EHN; pfam06441 101510009068 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510009069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510009070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510009071 active site 101510009072 ATP binding site [chemical binding]; other site 101510009073 substrate binding site [chemical binding]; other site 101510009074 activation loop (A-loop); other site 101510009075 Predicted ATPase [General function prediction only]; Region: COG3903 101510009076 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510009077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510009078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510009079 DNA binding residues [nucleotide binding] 101510009080 dimerization interface [polypeptide binding]; other site 101510009081 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 101510009082 Isochorismatase family; Region: Isochorismatase; pfam00857 101510009083 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 101510009084 catalytic triad [active] 101510009085 conserved cis-peptide bond; other site 101510009086 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 101510009087 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 101510009088 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 101510009089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510009090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510009091 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 101510009092 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 101510009093 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 101510009094 E3 interaction surface; other site 101510009095 lipoyl attachment site [posttranslational modification]; other site 101510009096 e3 binding domain; Region: E3_binding; pfam02817 101510009097 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 101510009098 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 101510009099 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 101510009100 alpha subunit interface [polypeptide binding]; other site 101510009101 TPP binding site [chemical binding]; other site 101510009102 heterodimer interface [polypeptide binding]; other site 101510009103 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510009104 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 101510009105 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 101510009106 TPP-binding site [chemical binding]; other site 101510009107 tetramer interface [polypeptide binding]; other site 101510009108 heterodimer interface [polypeptide binding]; other site 101510009109 phosphorylation loop region [posttranslational modification] 101510009110 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510009111 AsnC family; Region: AsnC_trans_reg; pfam01037 101510009112 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 101510009113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510009114 putative substrate translocation pore; other site 101510009115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510009116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009117 Predicted acyl esterases [General function prediction only]; Region: COG2936 101510009118 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 101510009119 Putative cyclase; Region: Cyclase; pfam04199 101510009120 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510009121 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510009122 FAD binding domain; Region: FAD_binding_4; pfam01565 101510009123 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 101510009124 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 101510009125 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510009126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510009127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510009129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510009130 active site 101510009131 putative acyltransferase; Provisional; Region: PRK05790 101510009132 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510009133 dimer interface [polypeptide binding]; other site 101510009134 active site 101510009135 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 101510009136 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 101510009137 NAD binding site [chemical binding]; other site 101510009138 homodimer interface [polypeptide binding]; other site 101510009139 homotetramer interface [polypeptide binding]; other site 101510009140 active site 101510009141 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 101510009142 tetracycline repressor protein TetR; Provisional; Region: PRK13756 101510009143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009144 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510009145 PAS fold; Region: PAS_3; pfam08447 101510009146 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510009147 Lsr2; Region: Lsr2; pfam11774 101510009148 Gas vesicle protein; Region: Gas_vesicle; pfam00741 101510009149 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 101510009150 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 101510009151 Gas vesicle protein; Region: Gas_vesicle; cl02954 101510009152 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 101510009153 putative hydrophobic ligand binding site [chemical binding]; other site 101510009154 PAS domain; Region: PAS_9; pfam13426 101510009155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 101510009156 putative active site [active] 101510009157 heme pocket [chemical binding]; other site 101510009158 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510009159 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 101510009160 Hemerythrin-like domain; Region: Hr-like; cd12108 101510009161 Fe binding site [ion binding]; other site 101510009162 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 101510009163 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 101510009164 heme binding pocket [chemical binding]; other site 101510009165 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 101510009166 domain interactions; other site 101510009167 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 101510009168 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 101510009169 putative di-iron ligands [ion binding]; other site 101510009170 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 101510009171 oxidoreductase; Provisional; Region: PRK06196 101510009172 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 101510009173 putative NAD(P) binding site [chemical binding]; other site 101510009174 active site 101510009175 Domain of unknown function (DUF222); Region: DUF222; pfam02720 101510009176 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510009177 active site 101510009178 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 101510009179 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 101510009180 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 101510009181 replicative DNA helicase; Region: DnaB; TIGR00665 101510009182 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 101510009183 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 101510009184 Walker A motif; other site 101510009185 ATP binding site [chemical binding]; other site 101510009186 Walker B motif; other site 101510009187 DNA binding loops [nucleotide binding] 101510009188 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 101510009189 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 101510009190 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 101510009191 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 101510009192 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 101510009193 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 101510009194 dimer interface [polypeptide binding]; other site 101510009195 ssDNA binding site [nucleotide binding]; other site 101510009196 tetramer (dimer of dimers) interface [polypeptide binding]; other site 101510009197 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 101510009198 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 101510009199 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 101510009200 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 101510009201 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510009202 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510009203 substrate binding pocket [chemical binding]; other site 101510009204 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510009205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510009206 Predicted ATPase [General function prediction only]; Region: COG3903 101510009207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510009208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 101510009209 TPR motif; other site 101510009210 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510009211 binding surface 101510009212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510009213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510009214 DNA binding residues [nucleotide binding] 101510009215 dimerization interface [polypeptide binding]; other site 101510009216 Interferon-induced transmembrane protein; Region: CD225; pfam04505 101510009217 Predicted integral membrane protein [Function unknown]; Region: COG5650 101510009218 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 101510009219 Transglycosylase; Region: Transgly; pfam00912 101510009220 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 101510009221 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 101510009222 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 101510009223 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 101510009224 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510009225 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 101510009226 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 101510009227 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 101510009228 Transglycosylase; Region: Transgly; pfam00912 101510009229 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 101510009230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 101510009231 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 101510009232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510009233 dimer interface [polypeptide binding]; other site 101510009234 conserved gate region; other site 101510009235 putative PBP binding loops; other site 101510009236 ABC-ATPase subunit interface; other site 101510009237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 101510009238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510009239 dimer interface [polypeptide binding]; other site 101510009240 conserved gate region; other site 101510009241 putative PBP binding loops; other site 101510009242 ABC-ATPase subunit interface; other site 101510009243 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 101510009244 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 101510009245 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 101510009246 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 101510009247 Walker A/P-loop; other site 101510009248 ATP binding site [chemical binding]; other site 101510009249 Q-loop/lid; other site 101510009250 ABC transporter signature motif; other site 101510009251 Walker B; other site 101510009252 D-loop; other site 101510009253 H-loop/switch region; other site 101510009254 TOBE domain; Region: TOBE_2; pfam08402 101510009255 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 101510009256 putative dimer interface [polypeptide binding]; other site 101510009257 putative [2Fe-2S] cluster binding site [ion binding]; other site 101510009258 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 101510009259 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 101510009260 siderophore binding site; other site 101510009261 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 101510009262 Domain of unknown function (DUF385); Region: DUF385; cl04387 101510009263 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 101510009264 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 101510009265 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510009266 dimer interface [polypeptide binding]; other site 101510009267 active site 101510009268 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510009269 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510009270 acyl-activating enzyme (AAE) consensus motif; other site 101510009271 AMP binding site [chemical binding]; other site 101510009272 active site 101510009273 CoA binding site [chemical binding]; other site 101510009274 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 101510009275 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 101510009276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510009277 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 101510009278 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510009279 EamA-like transporter family; Region: EamA; pfam00892 101510009280 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 101510009281 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510009282 active site 101510009283 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510009284 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510009285 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510009286 acyl-activating enzyme (AAE) consensus motif; other site 101510009287 acyl-activating enzyme (AAE) consensus motif; other site 101510009288 putative AMP binding site [chemical binding]; other site 101510009289 putative active site [active] 101510009290 putative CoA binding site [chemical binding]; other site 101510009291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009292 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510009293 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510009294 substrate binding pocket [chemical binding]; other site 101510009295 membrane-bound complex binding site; other site 101510009296 hinge residues; other site 101510009297 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 101510009298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510009299 dimer interface [polypeptide binding]; other site 101510009300 conserved gate region; other site 101510009301 putative PBP binding loops; other site 101510009302 ABC-ATPase subunit interface; other site 101510009303 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510009304 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510009305 Walker A/P-loop; other site 101510009306 ATP binding site [chemical binding]; other site 101510009307 Q-loop/lid; other site 101510009308 ABC transporter signature motif; other site 101510009309 Walker B; other site 101510009310 D-loop; other site 101510009311 H-loop/switch region; other site 101510009312 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 101510009313 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 101510009314 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 101510009315 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 101510009316 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 101510009317 putative active site [active] 101510009318 hypothetical protein; Provisional; Region: PRK05463 101510009319 benzoate transport; Region: 2A0115; TIGR00895 101510009320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510009321 putative substrate translocation pore; other site 101510009322 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510009323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510009324 DNA-binding site [nucleotide binding]; DNA binding site 101510009325 FCD domain; Region: FCD; pfam07729 101510009326 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510009327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510009328 DNA-binding site [nucleotide binding]; DNA binding site 101510009329 FCD domain; Region: FCD; pfam07729 101510009330 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 101510009331 Cysteine-rich domain; Region: CCG; pfam02754 101510009332 Cysteine-rich domain; Region: CCG; pfam02754 101510009333 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 101510009334 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 101510009335 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 101510009336 Uncharacterized conserved protein [Function unknown]; Region: COG1556 101510009337 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510009338 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510009339 hypothetical protein; Provisional; Region: PRK07945 101510009340 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 101510009341 active site 101510009342 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 101510009343 NADH(P)-binding; Region: NAD_binding_10; pfam13460 101510009344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510009345 NAD(P) binding site [chemical binding]; other site 101510009346 active site 101510009347 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 101510009348 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 101510009349 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 101510009350 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 101510009351 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 101510009352 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 101510009353 putative hydrophobic ligand binding site [chemical binding]; other site 101510009354 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 101510009355 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 101510009356 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 101510009357 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 101510009358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510009359 catalytic loop [active] 101510009360 iron binding site [ion binding]; other site 101510009361 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 101510009362 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 101510009363 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 101510009364 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 101510009365 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510009366 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 101510009367 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 101510009368 XdhC Rossmann domain; Region: XdhC_C; pfam13478 101510009369 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510009370 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510009371 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 101510009372 Amidase; Region: Amidase; cl11426 101510009373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510009374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510009375 putative substrate translocation pore; other site 101510009376 prolyl-tRNA synthetase; Provisional; Region: PRK08661 101510009377 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 101510009378 dimer interface [polypeptide binding]; other site 101510009379 motif 1; other site 101510009380 active site 101510009381 motif 2; other site 101510009382 motif 3; other site 101510009383 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 101510009384 anticodon binding site; other site 101510009385 zinc-binding site [ion binding]; other site 101510009386 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 101510009387 active site 101510009388 putative catalytic site [active] 101510009389 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 101510009390 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 101510009391 DNA binding residues [nucleotide binding] 101510009392 PIN domain; Region: PIN_3; pfam13470 101510009393 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510009394 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510009395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 101510009396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510009397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009398 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 101510009399 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 101510009400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510009401 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 101510009402 DNA binding residues [nucleotide binding] 101510009403 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510009404 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 101510009405 HEAT repeats; Region: HEAT_2; pfam13646 101510009406 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 101510009407 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510009408 DNA binding residues [nucleotide binding] 101510009409 putative dimer interface [polypeptide binding]; other site 101510009410 HEAT repeats; Region: HEAT_2; pfam13646 101510009411 Gas vesicle protein; Region: Gas_vesicle; cl02954 101510009412 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 101510009413 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 101510009414 Part of AAA domain; Region: AAA_19; pfam13245 101510009415 Family description; Region: UvrD_C_2; pfam13538 101510009416 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 101510009417 homodimer interface [polypeptide binding]; other site 101510009418 active site 101510009419 TDP-binding site; other site 101510009420 acceptor substrate-binding pocket; other site 101510009421 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 101510009422 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 101510009423 active site 101510009424 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 101510009425 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 101510009426 agmatinase; Region: agmatinase; TIGR01230 101510009427 oligomer interface [polypeptide binding]; other site 101510009428 putative active site [active] 101510009429 Mn binding site [ion binding]; other site 101510009430 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 101510009431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510009432 non-specific DNA binding site [nucleotide binding]; other site 101510009433 salt bridge; other site 101510009434 sequence-specific DNA binding site [nucleotide binding]; other site 101510009435 Cupin domain; Region: Cupin_2; pfam07883 101510009436 amino acid transporter; Region: 2A0306; TIGR00909 101510009437 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 101510009438 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510009439 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 101510009440 putative active site [active] 101510009441 catalytic triad [active] 101510009442 putative dimer interface [polypeptide binding]; other site 101510009443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510009444 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 101510009445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 101510009446 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510009447 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510009448 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 101510009449 Leucine carboxyl methyltransferase; Region: LCM; cl01306 101510009450 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 101510009451 metal-binding site [ion binding] 101510009452 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 101510009453 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 101510009454 metal-binding site [ion binding] 101510009455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510009456 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 101510009457 putative homodimer interface [polypeptide binding]; other site 101510009458 putative homotetramer interface [polypeptide binding]; other site 101510009459 putative allosteric switch controlling residues; other site 101510009460 putative metal binding site [ion binding]; other site 101510009461 putative homodimer-homodimer interface [polypeptide binding]; other site 101510009462 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 101510009463 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510009464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510009465 motif II; other site 101510009466 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 101510009467 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510009468 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510009469 Predicted membrane protein [Function unknown]; Region: COG2855 101510009470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510009471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510009472 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 101510009473 putative dimerization interface [polypeptide binding]; other site 101510009474 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510009475 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 101510009476 hypothetical protein; Provisional; Region: PRK06541 101510009477 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510009478 inhibitor-cofactor binding pocket; inhibition site 101510009479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510009480 catalytic residue [active] 101510009481 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 101510009482 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 101510009483 hexamer interface [polypeptide binding]; other site 101510009484 ligand binding site [chemical binding]; other site 101510009485 putative active site [active] 101510009486 NAD(P) binding site [chemical binding]; other site 101510009487 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 101510009488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510009489 DNA-binding site [nucleotide binding]; DNA binding site 101510009490 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510009491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510009492 homodimer interface [polypeptide binding]; other site 101510009493 catalytic residue [active] 101510009494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510009495 Q-loop/lid; other site 101510009496 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 101510009497 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 101510009498 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 101510009499 NAD binding site [chemical binding]; other site 101510009500 catalytic Zn binding site [ion binding]; other site 101510009501 structural Zn binding site [ion binding]; other site 101510009502 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 101510009503 intracellular protease, PfpI family; Region: PfpI; TIGR01382 101510009504 proposed catalytic triad [active] 101510009505 conserved cys residue [active] 101510009506 Domain of unknown function (DUF336); Region: DUF336; pfam03928 101510009507 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 101510009508 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 101510009509 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 101510009510 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 101510009511 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 101510009512 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 101510009513 RibD C-terminal domain; Region: RibD_C; cl17279 101510009514 PAS fold; Region: PAS_3; pfam08447 101510009515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 101510009516 putative active site [active] 101510009517 heme pocket [chemical binding]; other site 101510009518 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510009519 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 101510009520 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510009521 DNA binding residues [nucleotide binding] 101510009522 putative dimer interface [polypeptide binding]; other site 101510009523 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 101510009524 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 101510009525 putative dimer interface [polypeptide binding]; other site 101510009526 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 101510009527 HSP70 interaction site [polypeptide binding]; other site 101510009528 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510009529 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 101510009530 GAF domain; Region: GAF; pfam01590 101510009531 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 101510009532 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 101510009533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510009534 active site 101510009535 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510009536 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 101510009537 anti sigma factor interaction site; other site 101510009538 regulatory phosphorylation site [posttranslational modification]; other site 101510009539 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 101510009540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 101510009541 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510009542 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 101510009543 active site 101510009544 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510009545 Na binding site [ion binding]; other site 101510009546 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 101510009547 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 101510009548 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510009549 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510009550 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 101510009551 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510009552 PYR/PP interface [polypeptide binding]; other site 101510009553 dimer interface [polypeptide binding]; other site 101510009554 TPP binding site [chemical binding]; other site 101510009555 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510009556 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 101510009557 TPP-binding site; other site 101510009558 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510009559 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510009560 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510009561 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 101510009562 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 101510009563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510009564 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 101510009565 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 101510009566 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 101510009567 metal ion-dependent adhesion site (MIDAS); other site 101510009568 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 101510009569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510009570 motif II; other site 101510009571 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 101510009572 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 101510009573 active site 101510009574 multimer interface [polypeptide binding]; other site 101510009575 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 101510009576 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 101510009577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510009578 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510009579 substrate binding pocket [chemical binding]; other site 101510009580 membrane-bound complex binding site; other site 101510009581 hinge residues; other site 101510009582 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510009583 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510009584 active site 101510009585 ATP binding site [chemical binding]; other site 101510009586 substrate binding site [chemical binding]; other site 101510009587 activation loop (A-loop); other site 101510009588 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 101510009589 ThiS interaction site; other site 101510009590 putative active site [active] 101510009591 tetramer interface [polypeptide binding]; other site 101510009592 hypothetical protein; Provisional; Region: PRK07945 101510009593 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 101510009594 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 101510009595 active site 101510009596 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 101510009597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510009598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510009599 dimerization interface [polypeptide binding]; other site 101510009600 Lysine efflux permease [General function prediction only]; Region: COG1279 101510009601 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 101510009602 short chain dehydrogenase; Provisional; Region: PRK08219 101510009603 classical (c) SDRs; Region: SDR_c; cd05233 101510009604 NAD(P) binding site [chemical binding]; other site 101510009605 active site 101510009606 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 101510009607 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510009608 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510009609 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510009610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510009611 DNA-binding site [nucleotide binding]; DNA binding site 101510009612 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 101510009613 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 101510009614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510009615 motif II; other site 101510009616 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 101510009617 CAAX protease self-immunity; Region: Abi; pfam02517 101510009618 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510009619 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 101510009620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510009621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510009622 enoyl-CoA hydratase; Provisional; Region: PRK08138 101510009623 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510009624 substrate binding site [chemical binding]; other site 101510009625 oxyanion hole (OAH) forming residues; other site 101510009626 trimer interface [polypeptide binding]; other site 101510009627 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510009628 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510009629 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510009630 active site 101510009631 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 101510009632 CoA binding domain; Region: CoA_binding_2; pfam13380 101510009633 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 101510009634 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 101510009635 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510009636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510009637 NAD(P) binding site [chemical binding]; other site 101510009638 active site 101510009639 TetR family transcriptional regulator; Provisional; Region: PRK14996 101510009640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009641 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510009642 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 101510009643 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 101510009644 HIGH motif; other site 101510009645 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 101510009646 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 101510009647 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 101510009648 active site 101510009649 KMSKS motif; other site 101510009650 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 101510009651 tRNA binding surface [nucleotide binding]; other site 101510009652 anticodon binding site; other site 101510009653 SdpI/YhfL protein family; Region: SdpI; pfam13630 101510009654 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 101510009655 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510009656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510009657 DNA-binding site [nucleotide binding]; DNA binding site 101510009658 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 101510009659 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 101510009660 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 101510009661 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 101510009662 Uncharacterized conserved protein [Function unknown]; Region: COG1656 101510009663 Protein of unknown function DUF82; Region: DUF82; pfam01927 101510009664 hypothetical protein; Validated; Region: PRK00228 101510009665 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 101510009666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510009667 NAD(P) binding site [chemical binding]; other site 101510009668 active site 101510009669 H+ Antiporter protein; Region: 2A0121; TIGR00900 101510009670 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510009671 CoenzymeA binding site [chemical binding]; other site 101510009672 subunit interaction site [polypeptide binding]; other site 101510009673 PHB binding site; other site 101510009674 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510009675 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 101510009676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510009677 Walker A/P-loop; other site 101510009678 ATP binding site [chemical binding]; other site 101510009679 Q-loop/lid; other site 101510009680 ABC transporter signature motif; other site 101510009681 Walker B; other site 101510009682 D-loop; other site 101510009683 H-loop/switch region; other site 101510009684 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 101510009685 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 101510009686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510009687 putative PBP binding loops; other site 101510009688 ABC-ATPase subunit interface; other site 101510009689 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 101510009690 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 101510009691 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 101510009692 DNA binding residues [nucleotide binding] 101510009693 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510009694 TOBE domain; Region: TOBE; cl01440 101510009695 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 101510009696 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 101510009697 [4Fe-4S] binding site [ion binding]; other site 101510009698 molybdopterin cofactor binding site; other site 101510009699 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 101510009700 molybdopterin cofactor binding site; other site 101510009701 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 101510009702 Flavodoxin; Region: Flavodoxin_1; pfam00258 101510009703 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 101510009704 FAD binding pocket [chemical binding]; other site 101510009705 FAD binding motif [chemical binding]; other site 101510009706 catalytic residues [active] 101510009707 NAD binding pocket [chemical binding]; other site 101510009708 phosphate binding motif [ion binding]; other site 101510009709 beta-alpha-beta structure motif; other site 101510009710 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 101510009711 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 101510009712 active site 101510009713 NTP binding site [chemical binding]; other site 101510009714 metal binding triad [ion binding]; metal-binding site 101510009715 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 101510009716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 101510009717 Zn2+ binding site [ion binding]; other site 101510009718 Mg2+ binding site [ion binding]; other site 101510009719 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 101510009720 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 101510009721 active site 101510009722 Ap6A binding site [chemical binding]; other site 101510009723 nudix motif; other site 101510009724 metal binding site [ion binding]; metal-binding site 101510009725 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 101510009726 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 101510009727 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 101510009728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510009729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510009730 DNA binding residues [nucleotide binding] 101510009731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510009732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009733 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 101510009734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510009735 NAD(P) binding site [chemical binding]; other site 101510009736 active site 101510009737 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510009738 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 101510009739 active site 101510009740 FMN binding site [chemical binding]; other site 101510009741 substrate binding site [chemical binding]; other site 101510009742 putative catalytic residue [active] 101510009743 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 101510009744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510009745 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 101510009746 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 101510009747 catalytic residues [active] 101510009748 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 101510009749 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 101510009750 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 101510009751 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 101510009752 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 101510009753 active site 101510009754 metal binding site [ion binding]; metal-binding site 101510009755 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 101510009756 ParB-like nuclease domain; Region: ParBc; pfam02195 101510009757 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510009758 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510009759 P-loop; other site 101510009760 Magnesium ion binding site [ion binding]; other site 101510009761 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 101510009762 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 101510009763 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 101510009764 SnoaL-like domain; Region: SnoaL_3; pfam13474 101510009765 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 101510009766 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 101510009767 G-X-X-G motif; other site 101510009768 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 101510009769 RxxxH motif; other site 101510009770 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 101510009771 hypothetical protein; Validated; Region: PRK00041 101510009772 ribonuclease P; Reviewed; Region: rnpA; PRK03459 101510009773 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 101510009774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510009775 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 101510009776 Walker A motif; other site 101510009777 ATP binding site [chemical binding]; other site 101510009778 Walker B motif; other site 101510009779 arginine finger; other site 101510009780 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 101510009781 DnaA box-binding interface [nucleotide binding]; other site 101510009782 DNA polymerase III subunit beta; Validated; Region: PRK07761 101510009783 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 101510009784 putative DNA binding surface [nucleotide binding]; other site 101510009785 dimer interface [polypeptide binding]; other site 101510009786 beta-clamp/clamp loader binding surface; other site 101510009787 beta-clamp/translesion DNA polymerase binding surface; other site 101510009788 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510009789 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 101510009790 recombination protein F; Reviewed; Region: recF; PRK00064 101510009791 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 101510009792 Walker A/P-loop; other site 101510009793 ATP binding site [chemical binding]; other site 101510009794 Q-loop/lid; other site 101510009795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510009796 ABC transporter signature motif; other site 101510009797 Walker B; other site 101510009798 D-loop; other site 101510009799 H-loop/switch region; other site 101510009800 hypothetical protein; Provisional; Region: PRK03195 101510009801 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 101510009802 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 101510009803 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510009804 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510009805 FMN-binding pocket [chemical binding]; other site 101510009806 flavin binding motif; other site 101510009807 phosphate binding motif [ion binding]; other site 101510009808 beta-alpha-beta structure motif; other site 101510009809 NAD binding pocket [chemical binding]; other site 101510009810 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510009811 catalytic loop [active] 101510009812 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510009813 iron binding site [ion binding]; other site 101510009814 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510009815 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 101510009816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510009817 ATP binding site [chemical binding]; other site 101510009818 Mg2+ binding site [ion binding]; other site 101510009819 G-X-G motif; other site 101510009820 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 101510009821 anchoring element; other site 101510009822 dimer interface [polypeptide binding]; other site 101510009823 ATP binding site [chemical binding]; other site 101510009824 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 101510009825 active site 101510009826 putative metal-binding site [ion binding]; other site 101510009827 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 101510009828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510009829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510009830 ATP binding site [chemical binding]; other site 101510009831 Mg2+ binding site [ion binding]; other site 101510009832 G-X-G motif; other site 101510009833 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 101510009834 Protein of unknown function (DUF742); Region: DUF742; pfam05331 101510009835 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 101510009836 Switch I region; other site 101510009837 G3 box; other site 101510009838 Switch II region; other site 101510009839 GTP/Mg2+ binding site [chemical binding]; other site 101510009840 G4 box; other site 101510009841 G5 box; other site 101510009842 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 101510009843 DNA gyrase subunit A; Validated; Region: PRK05560 101510009844 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 101510009845 CAP-like domain; other site 101510009846 active site 101510009847 primary dimer interface [polypeptide binding]; other site 101510009848 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 101510009849 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 101510009850 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 101510009851 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 101510009852 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 101510009853 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 101510009854 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 101510009855 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 101510009856 FAD binding pocket [chemical binding]; other site 101510009857 FAD binding motif [chemical binding]; other site 101510009858 phosphate binding motif [ion binding]; other site 101510009859 NAD binding pocket [chemical binding]; other site 101510009860 Chorismate mutase type II; Region: CM_2; cl00693 101510009861 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 101510009862 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 101510009863 conserved cys residue [active] 101510009864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510009865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510009866 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 101510009867 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 101510009868 active site 101510009869 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 101510009870 Rhomboid family; Region: Rhomboid; pfam01694 101510009871 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 101510009872 putative septation inhibitor protein; Reviewed; Region: PRK00159 101510009873 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 101510009874 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 101510009875 Glutamine amidotransferase class-I; Region: GATase; pfam00117 101510009876 glutamine binding [chemical binding]; other site 101510009877 catalytic triad [active] 101510009878 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510009879 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510009880 active site 101510009881 ATP binding site [chemical binding]; other site 101510009882 substrate binding site [chemical binding]; other site 101510009883 activation loop (A-loop); other site 101510009884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 101510009885 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 101510009886 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 101510009887 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 101510009888 PASTA domain; Region: PASTA; pfam03793 101510009889 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510009890 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510009891 active site 101510009892 ATP binding site [chemical binding]; other site 101510009893 substrate binding site [chemical binding]; other site 101510009894 activation loop (A-loop); other site 101510009895 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 101510009896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 101510009897 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 101510009898 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 101510009899 active site 101510009900 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510009901 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510009902 phosphopeptide binding site; other site 101510009903 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 101510009904 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510009905 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510009906 phosphopeptide binding site; other site 101510009907 RDD family; Region: RDD; pfam06271 101510009908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510009909 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 101510009910 dimer interface [polypeptide binding]; other site 101510009911 ligand binding site [chemical binding]; other site 101510009912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510009913 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 101510009914 hypothetical protein; Provisional; Region: PRK07236 101510009915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 101510009916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009917 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 101510009918 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 101510009919 active site 101510009920 dimer interface [polypeptide binding]; other site 101510009921 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 101510009922 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 101510009923 active site 101510009924 FMN binding site [chemical binding]; other site 101510009925 substrate binding site [chemical binding]; other site 101510009926 3Fe-4S cluster binding site [ion binding]; other site 101510009927 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 101510009928 domain interface; other site 101510009929 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 101510009930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510009931 Cutinase; Region: Cutinase; pfam01083 101510009932 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 101510009933 active site 101510009934 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510009935 hydrophobic ligand binding site; other site 101510009936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510009937 NAD(P) binding site [chemical binding]; other site 101510009938 active site 101510009939 short chain dehydrogenase; Provisional; Region: PRK07832 101510009940 classical (c) SDRs; Region: SDR_c; cd05233 101510009941 NAD(P) binding site [chemical binding]; other site 101510009942 active site 101510009943 DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242 101510009944 Uncharacterized conserved protein [Function unknown]; Region: COG1359 101510009945 Dienelactone hydrolase family; Region: DLH; pfam01738 101510009946 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510009947 nucleotide binding site [chemical binding]; other site 101510009948 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510009949 nucleotide binding site [chemical binding]; other site 101510009950 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510009951 catalytic core [active] 101510009952 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510009953 Protein of unknown function (DUF998); Region: DUF998; pfam06197 101510009954 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 101510009955 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 101510009956 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 101510009957 dimer interface [polypeptide binding]; other site 101510009958 putative anticodon binding site; other site 101510009959 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 101510009960 motif 1; other site 101510009961 dimer interface [polypeptide binding]; other site 101510009962 active site 101510009963 motif 2; other site 101510009964 motif 3; other site 101510009965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 101510009966 RNA binding surface [nucleotide binding]; other site 101510009967 hypothetical protein; Provisional; Region: PRK07907 101510009968 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 101510009969 active site 101510009970 metal binding site [ion binding]; metal-binding site 101510009971 dimer interface [polypeptide binding]; other site 101510009972 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 101510009973 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 101510009974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510009975 NAD(P) binding site [chemical binding]; other site 101510009976 active site 101510009977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510009978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510009979 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 101510009980 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510009981 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510009982 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 101510009983 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510009984 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 101510009985 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 101510009986 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510009987 carboxyltransferase (CT) interaction site; other site 101510009988 biotinylation site [posttranslational modification]; other site 101510009989 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 101510009990 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510009991 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510009992 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510009993 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 101510009994 DNA binding residues [nucleotide binding] 101510009995 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 101510009996 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 101510009997 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 101510009998 acyl-activating enzyme (AAE) consensus motif; other site 101510009999 putative AMP binding site [chemical binding]; other site 101510010000 putative active site [active] 101510010001 putative CoA binding site [chemical binding]; other site 101510010002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510010003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010004 putative substrate translocation pore; other site 101510010005 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 101510010006 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 101510010007 conserved cys residue [active] 101510010008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510010009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 101510010010 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 101510010011 Membrane protein of unknown function; Region: DUF360; pfam04020 101510010012 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 101510010013 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 101510010014 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 101510010015 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 101510010016 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 101510010017 Sulfate transporter family; Region: Sulfate_transp; pfam00916 101510010018 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 101510010019 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 101510010020 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 101510010021 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510010022 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 101510010023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510010024 motif II; other site 101510010025 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 101510010026 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 101510010027 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 101510010028 Short C-terminal domain; Region: SHOCT; pfam09851 101510010029 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 101510010030 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 101510010031 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 101510010032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 101510010033 Domain of unknown function DUF20; Region: UPF0118; pfam01594 101510010034 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 101510010035 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 101510010036 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 101510010037 Uncharacterized conserved protein [Function unknown]; Region: COG5361 101510010038 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510010039 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510010040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510010041 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510010042 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510010043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510010044 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 101510010045 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510010046 Predicted membrane protein [Function unknown]; Region: COG4425 101510010047 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 101510010048 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 101510010049 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 101510010050 putative active site [active] 101510010051 putative catalytic site [active] 101510010052 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 101510010053 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 101510010054 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 101510010055 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 101510010056 acyl-activating enzyme (AAE) consensus motif; other site 101510010057 putative AMP binding site [chemical binding]; other site 101510010058 putative active site [active] 101510010059 putative CoA binding site [chemical binding]; other site 101510010060 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 101510010061 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 101510010062 Serine hydrolase; Region: Ser_hydrolase; pfam06821 101510010063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510010064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010065 putative substrate translocation pore; other site 101510010066 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 101510010067 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 101510010068 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 101510010069 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 101510010070 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 101510010071 NADP binding site [chemical binding]; other site 101510010072 dimer interface [polypeptide binding]; other site 101510010073 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 101510010074 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 101510010075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510010076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 101510010077 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 101510010078 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 101510010079 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 101510010080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010081 putative substrate translocation pore; other site 101510010082 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 101510010083 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 101510010084 dimer interface [polypeptide binding]; other site 101510010085 NADP binding site [chemical binding]; other site 101510010086 catalytic residues [active] 101510010087 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 101510010088 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510010089 catalytic residue [active] 101510010090 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 101510010091 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 101510010092 active site 101510010093 tetramer interface [polypeptide binding]; other site 101510010094 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 101510010095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510010096 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 101510010097 putative dimerization interface [polypeptide binding]; other site 101510010098 putative substrate binding pocket [chemical binding]; other site 101510010099 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 101510010100 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 101510010101 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510010102 DinB superfamily; Region: DinB_2; pfam12867 101510010103 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 101510010104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510010105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 101510010106 Coenzyme A binding pocket [chemical binding]; other site 101510010107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510010108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510010109 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 101510010110 Walker A/P-loop; other site 101510010111 ATP binding site [chemical binding]; other site 101510010112 Q-loop/lid; other site 101510010113 ABC transporter signature motif; other site 101510010114 Walker B; other site 101510010115 D-loop; other site 101510010116 H-loop/switch region; other site 101510010117 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510010118 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510010119 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 101510010120 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510010121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510010122 DNA binding residues [nucleotide binding] 101510010123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510010124 dimerization interface [polypeptide binding]; other site 101510010125 putative DNA binding site [nucleotide binding]; other site 101510010126 putative Zn2+ binding site [ion binding]; other site 101510010127 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 101510010128 putative hydrophobic ligand binding site [chemical binding]; other site 101510010129 RibD C-terminal domain; Region: RibD_C; cl17279 101510010130 Carboxylesterase family; Region: COesterase; pfam00135 101510010131 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510010132 substrate binding pocket [chemical binding]; other site 101510010133 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510010134 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510010135 classical (c) SDRs; Region: SDR_c; cd05233 101510010136 NAD(P) binding site [chemical binding]; other site 101510010137 active site 101510010138 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 101510010139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510010140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510010141 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510010142 dimerization interface [polypeptide binding]; other site 101510010143 substrate binding pocket [chemical binding]; other site 101510010144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510010145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510010146 substrate binding pocket [chemical binding]; other site 101510010147 membrane-bound complex binding site; other site 101510010148 hinge residues; other site 101510010149 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 101510010150 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510010151 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510010152 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510010153 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 101510010154 SnoaL-like domain; Region: SnoaL_3; pfam13474 101510010155 guanine deaminase; Provisional; Region: PRK09228 101510010156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510010157 active site 101510010158 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510010159 Cytochrome P450; Region: p450; cl12078 101510010160 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 101510010161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510010162 S-adenosylmethionine binding site [chemical binding]; other site 101510010163 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 101510010164 Putative zinc-finger; Region: zf-HC2; pfam13490 101510010165 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 101510010166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510010167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510010168 DNA binding residues [nucleotide binding] 101510010169 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510010170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510010171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510010172 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 101510010173 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 101510010174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510010175 Walker A/P-loop; other site 101510010176 ATP binding site [chemical binding]; other site 101510010177 Q-loop/lid; other site 101510010178 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 101510010179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510010180 Walker A/P-loop; other site 101510010181 ATP binding site [chemical binding]; other site 101510010182 Q-loop/lid; other site 101510010183 ABC transporter signature motif; other site 101510010184 Walker B; other site 101510010185 D-loop; other site 101510010186 H-loop/switch region; other site 101510010187 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510010188 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510010189 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510010190 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510010191 active site 101510010192 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 101510010193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510010194 DNA binding residues [nucleotide binding] 101510010195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 101510010196 Transcription factor WhiB; Region: Whib; pfam02467 101510010197 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510010198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510010199 NAD(P) binding site [chemical binding]; other site 101510010200 active site 101510010201 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510010202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010203 putative substrate translocation pore; other site 101510010204 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 101510010205 TPP-binding site [chemical binding]; other site 101510010206 dimer interface [polypeptide binding]; other site 101510010207 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 101510010208 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 101510010209 PYR/PP interface [polypeptide binding]; other site 101510010210 dimer interface [polypeptide binding]; other site 101510010211 TPP binding site [chemical binding]; other site 101510010212 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510010213 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510010214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510010215 DNA-binding site [nucleotide binding]; DNA binding site 101510010216 FCD domain; Region: FCD; pfam07729 101510010217 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 101510010218 active site 101510010219 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 101510010220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510010221 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 101510010222 Probable transposase; Region: OrfB_IS605; pfam01385 101510010223 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 101510010224 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510010225 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510010226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510010227 DNA binding site [nucleotide binding] 101510010228 domain linker motif; other site 101510010229 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 101510010230 ligand binding site [chemical binding]; other site 101510010231 dimerization interface [polypeptide binding]; other site 101510010232 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510010233 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 101510010234 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 101510010235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510010236 active site 101510010237 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 101510010238 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 101510010239 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510010240 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 101510010241 putative active site [active] 101510010242 catalytic triad [active] 101510010243 putative dimer interface [polypeptide binding]; other site 101510010244 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510010245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510010246 DNA-binding site [nucleotide binding]; DNA binding site 101510010247 FCD domain; Region: FCD; pfam07729 101510010248 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510010249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010250 putative substrate translocation pore; other site 101510010251 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510010252 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 101510010253 active site 101510010254 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510010255 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510010256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510010257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510010258 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 101510010259 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 101510010260 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510010261 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 101510010262 tetramer interface [polypeptide binding]; other site 101510010263 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 101510010264 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 101510010265 tetramer interface [polypeptide binding]; other site 101510010266 active site 101510010267 metal binding site [ion binding]; metal-binding site 101510010268 acetaldehyde dehydrogenase; Validated; Region: PRK08300 101510010269 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510010270 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 101510010271 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 101510010272 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 101510010273 active site 101510010274 catalytic residues [active] 101510010275 metal binding site [ion binding]; metal-binding site 101510010276 DmpG-like communication domain; Region: DmpG_comm; pfam07836 101510010277 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510010278 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 101510010279 NAD binding site [chemical binding]; other site 101510010280 catalytic residues [active] 101510010281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510010282 NAD(P) binding site [chemical binding]; other site 101510010283 active site 101510010284 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 101510010285 active site 1 [active] 101510010286 dimer interface [polypeptide binding]; other site 101510010287 hexamer interface [polypeptide binding]; other site 101510010288 active site 2 [active] 101510010289 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 101510010290 active site 1 [active] 101510010291 dimer interface [polypeptide binding]; other site 101510010292 hexamer interface [polypeptide binding]; other site 101510010293 active site 2 [active] 101510010294 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510010295 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 101510010296 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 101510010297 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510010298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510010299 EthD domain; Region: EthD; cl17553 101510010300 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 101510010301 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510010302 catalytic loop [active] 101510010303 iron binding site [ion binding]; other site 101510010304 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 101510010305 FAD binding pocket [chemical binding]; other site 101510010306 FAD binding motif [chemical binding]; other site 101510010307 phosphate binding motif [ion binding]; other site 101510010308 beta-alpha-beta structure motif; other site 101510010309 NAD binding pocket [chemical binding]; other site 101510010310 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510010311 Cytochrome P450; Region: p450; cl12078 101510010312 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510010313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510010314 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510010315 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510010316 active site 101510010317 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 101510010318 active site 1 [active] 101510010319 dimer interface [polypeptide binding]; other site 101510010320 hexamer interface [polypeptide binding]; other site 101510010321 active site 2 [active] 101510010322 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 101510010323 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 101510010324 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510010325 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510010326 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510010327 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 101510010328 putative metal binding site [ion binding]; other site 101510010329 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 101510010330 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 101510010331 active site 101510010332 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510010333 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510010334 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510010335 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510010336 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510010337 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510010338 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510010339 Ligand Binding Site [chemical binding]; other site 101510010340 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 101510010341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010342 putative substrate translocation pore; other site 101510010343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510010345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510010346 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510010347 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510010348 substrate binding site [chemical binding]; other site 101510010349 oxyanion hole (OAH) forming residues; other site 101510010350 trimer interface [polypeptide binding]; other site 101510010351 putative acyltransferase; Provisional; Region: PRK05790 101510010352 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510010353 dimer interface [polypeptide binding]; other site 101510010354 active site 101510010355 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 101510010356 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 101510010357 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510010358 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510010359 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510010360 YceI-like domain; Region: YceI; smart00867 101510010361 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 101510010362 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510010363 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510010364 MarR family; Region: MarR_2; pfam12802 101510010365 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 101510010366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510010367 Zn binding site [ion binding]; other site 101510010368 Pirin-related protein [General function prediction only]; Region: COG1741 101510010369 Pirin; Region: Pirin; pfam02678 101510010370 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 101510010371 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 101510010372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510010373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510010374 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510010375 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510010376 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 101510010377 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 101510010378 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510010379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510010380 DNA-binding site [nucleotide binding]; DNA binding site 101510010381 FCD domain; Region: FCD; pfam07729 101510010382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010383 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510010384 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510010385 hypothetical protein; Provisional; Region: PRK06126 101510010386 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510010387 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 101510010388 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 101510010389 putative active site [active] 101510010390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510010391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510010392 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 101510010393 putative dimerization interface [polypeptide binding]; other site 101510010394 EamA-like transporter family; Region: EamA; pfam00892 101510010395 Ctr copper transporter family; Region: Ctr; pfam04145 101510010396 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 101510010397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510010398 metal binding site [ion binding]; metal-binding site 101510010399 active site 101510010400 I-site; other site 101510010401 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510010402 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 101510010403 active site 101510010404 catalytic triad [active] 101510010405 dimer interface [polypeptide binding]; other site 101510010406 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510010407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510010408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510010409 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510010410 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 101510010411 FMN binding site [chemical binding]; other site 101510010412 active site 101510010413 substrate binding site [chemical binding]; other site 101510010414 catalytic residue [active] 101510010415 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510010416 Ligand Binding Site [chemical binding]; other site 101510010417 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 101510010418 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 101510010419 putative ligand binding site [chemical binding]; other site 101510010420 NAD binding site [chemical binding]; other site 101510010421 catalytic site [active] 101510010422 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 101510010423 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 101510010424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 101510010425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510010426 dimer interface [polypeptide binding]; other site 101510010427 conserved gate region; other site 101510010428 putative PBP binding loops; other site 101510010429 ABC-ATPase subunit interface; other site 101510010430 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 101510010431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510010432 dimer interface [polypeptide binding]; other site 101510010433 conserved gate region; other site 101510010434 putative PBP binding loops; other site 101510010435 ABC-ATPase subunit interface; other site 101510010436 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 101510010437 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510010438 Walker A/P-loop; other site 101510010439 ATP binding site [chemical binding]; other site 101510010440 Q-loop/lid; other site 101510010441 ABC transporter signature motif; other site 101510010442 Walker B; other site 101510010443 D-loop; other site 101510010444 H-loop/switch region; other site 101510010445 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 101510010446 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 101510010447 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510010448 Walker A/P-loop; other site 101510010449 ATP binding site [chemical binding]; other site 101510010450 Q-loop/lid; other site 101510010451 ABC transporter signature motif; other site 101510010452 Walker B; other site 101510010453 D-loop; other site 101510010454 H-loop/switch region; other site 101510010455 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 101510010456 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510010457 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 101510010458 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 101510010459 active site 101510010460 tetramer interface [polypeptide binding]; other site 101510010461 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 101510010462 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 101510010463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510010464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510010465 Walker A motif; other site 101510010466 ATP binding site [chemical binding]; other site 101510010467 Low affinity iron permease; Region: Iron_permease; cl12096 101510010468 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 101510010469 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 101510010470 NAD(P) binding site [chemical binding]; other site 101510010471 catalytic residues [active] 101510010472 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510010473 hydrophobic ligand binding site; other site 101510010474 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510010475 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 101510010476 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510010477 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510010478 acyl-activating enzyme (AAE) consensus motif; other site 101510010479 acyl-activating enzyme (AAE) consensus motif; other site 101510010480 putative AMP binding site [chemical binding]; other site 101510010481 putative active site [active] 101510010482 putative CoA binding site [chemical binding]; other site 101510010483 enoyl-CoA hydratase; Provisional; Region: PRK06688 101510010484 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510010485 substrate binding site [chemical binding]; other site 101510010486 oxyanion hole (OAH) forming residues; other site 101510010487 trimer interface [polypeptide binding]; other site 101510010488 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510010489 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 101510010490 NAD(P) binding site [chemical binding]; other site 101510010491 enoyl-CoA hydratase; Provisional; Region: PRK08252 101510010492 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510010493 substrate binding site [chemical binding]; other site 101510010494 oxyanion hole (OAH) forming residues; other site 101510010495 trimer interface [polypeptide binding]; other site 101510010496 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 101510010497 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510010498 dimer interface [polypeptide binding]; other site 101510010499 active site 101510010500 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 101510010501 NAD binding site [chemical binding]; other site 101510010502 homodimer interface [polypeptide binding]; other site 101510010503 homotetramer interface [polypeptide binding]; other site 101510010504 active site 101510010505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510010506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510010507 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510010508 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510010509 active site 101510010510 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 101510010511 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510010512 FMN binding site [chemical binding]; other site 101510010513 substrate binding site [chemical binding]; other site 101510010514 putative catalytic residue [active] 101510010515 enoyl-CoA hydratase; Provisional; Region: PRK08260 101510010516 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510010517 substrate binding site [chemical binding]; other site 101510010518 oxyanion hole (OAH) forming residues; other site 101510010519 trimer interface [polypeptide binding]; other site 101510010520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510010521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510010522 Pleckstrin homology-like domain; Region: PH-like; cl17171 101510010523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510010524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010525 putative substrate translocation pore; other site 101510010526 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510010527 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 101510010528 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510010529 acyl-activating enzyme (AAE) consensus motif; other site 101510010530 putative AMP binding site [chemical binding]; other site 101510010531 putative active site [active] 101510010532 acyl-activating enzyme (AAE) consensus motif; other site 101510010533 putative CoA binding site [chemical binding]; other site 101510010534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010535 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510010536 putative substrate translocation pore; other site 101510010537 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510010538 putative active site [active] 101510010539 putative substrate binding site [chemical binding]; other site 101510010540 ATP binding site [chemical binding]; other site 101510010541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510010542 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510010543 active site 101510010544 acyl-CoA synthetase; Validated; Region: PRK08316 101510010545 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510010546 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510010547 acyl-activating enzyme (AAE) consensus motif; other site 101510010548 putative AMP binding site [chemical binding]; other site 101510010549 putative active site [active] 101510010550 putative CoA binding site [chemical binding]; other site 101510010551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010552 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510010553 putative substrate translocation pore; other site 101510010554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510010555 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 101510010556 cyclase homology domain; Region: CHD; cd07302 101510010557 nucleotidyl binding site; other site 101510010558 metal binding site [ion binding]; metal-binding site 101510010559 dimer interface [polypeptide binding]; other site 101510010560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510010561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510010562 active site 101510010563 phosphorylation site [posttranslational modification] 101510010564 intermolecular recognition site; other site 101510010565 dimerization interface [polypeptide binding]; other site 101510010566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510010567 DNA binding residues [nucleotide binding] 101510010568 dimerization interface [polypeptide binding]; other site 101510010569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 101510010570 Histidine kinase; Region: HisKA_3; pfam07730 101510010571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510010572 ATP binding site [chemical binding]; other site 101510010573 Mg2+ binding site [ion binding]; other site 101510010574 G-X-G motif; other site 101510010575 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 101510010576 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510010577 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 101510010578 Walker A/P-loop; other site 101510010579 ATP binding site [chemical binding]; other site 101510010580 Q-loop/lid; other site 101510010581 ABC transporter signature motif; other site 101510010582 Walker B; other site 101510010583 D-loop; other site 101510010584 H-loop/switch region; other site 101510010585 benzoate transport; Region: 2A0115; TIGR00895 101510010586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010587 putative substrate translocation pore; other site 101510010588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510010589 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510010590 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 101510010591 NAD(P) binding site [chemical binding]; other site 101510010592 catalytic residues [active] 101510010593 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 101510010594 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510010595 active site 101510010596 metal binding site [ion binding]; metal-binding site 101510010597 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 101510010598 putative active site [active] 101510010599 Mn binding site [ion binding]; other site 101510010600 putative oligomer interface [polypeptide binding]; other site 101510010601 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 101510010602 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510010603 Cupin domain; Region: Cupin_2; pfam07883 101510010604 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510010605 classical (c) SDRs; Region: SDR_c; cd05233 101510010606 NAD(P) binding site [chemical binding]; other site 101510010607 active site 101510010608 short chain dehydrogenase; Provisional; Region: PRK07062 101510010609 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 101510010610 putative NAD(P) binding site [chemical binding]; other site 101510010611 putative active site [active] 101510010612 hypothetical protein; Provisional; Region: PRK07064 101510010613 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510010614 PYR/PP interface [polypeptide binding]; other site 101510010615 dimer interface [polypeptide binding]; other site 101510010616 TPP binding site [chemical binding]; other site 101510010617 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510010618 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 101510010619 TPP-binding site [chemical binding]; other site 101510010620 FAD binding domain; Region: FAD_binding_3; pfam01494 101510010621 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510010622 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 101510010623 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 101510010624 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510010625 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510010626 FMN-binding pocket [chemical binding]; other site 101510010627 flavin binding motif; other site 101510010628 phosphate binding motif [ion binding]; other site 101510010629 beta-alpha-beta structure motif; other site 101510010630 NAD binding pocket [chemical binding]; other site 101510010631 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510010632 catalytic loop [active] 101510010633 iron binding site [ion binding]; other site 101510010634 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510010635 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510010636 iron-sulfur cluster [ion binding]; other site 101510010637 [2Fe-2S] cluster binding site [ion binding]; other site 101510010638 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510010639 hydrophobic ligand binding site; other site 101510010640 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510010641 MarR family; Region: MarR; pfam01047 101510010642 MarR family; Region: MarR_2; cl17246 101510010643 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 101510010644 homotrimer interaction site [polypeptide binding]; other site 101510010645 putative active site [active] 101510010646 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 101510010647 Fe-S cluster binding site [ion binding]; other site 101510010648 active site 101510010649 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510010650 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 101510010651 putative NAD(P) binding site [chemical binding]; other site 101510010652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 101510010653 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510010654 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510010655 Copper resistance protein D; Region: CopD; pfam05425 101510010656 CopC domain; Region: CopC; pfam04234 101510010657 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 101510010658 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 101510010659 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 101510010660 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 101510010661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510010662 S-adenosylmethionine binding site [chemical binding]; other site 101510010663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510010664 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 101510010665 NAD(P) binding site [chemical binding]; other site 101510010666 active site 101510010667 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 101510010668 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 101510010669 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 101510010670 ligand binding site [chemical binding]; other site 101510010671 flexible hinge region; other site 101510010672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510010673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510010674 ATP binding site [chemical binding]; other site 101510010675 Mg2+ binding site [ion binding]; other site 101510010676 G-X-G motif; other site 101510010677 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 101510010678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510010679 active site 101510010680 phosphorylation site [posttranslational modification] 101510010681 intermolecular recognition site; other site 101510010682 dimerization interface [polypeptide binding]; other site 101510010683 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 101510010684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510010685 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 101510010686 Predicted membrane protein [Function unknown]; Region: COG2119 101510010687 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 101510010688 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 101510010689 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 101510010690 amidase; Provisional; Region: PRK07869 101510010691 Amidase; Region: Amidase; cl11426 101510010692 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 101510010693 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 101510010694 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 101510010695 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 101510010696 methionine sulfoxide reductase A; Provisional; Region: PRK00058 101510010697 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 101510010698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510010699 NADH(P)-binding; Region: NAD_binding_10; pfam13460 101510010700 NAD(P) binding site [chemical binding]; other site 101510010701 active site 101510010702 Cupin; Region: Cupin_6; pfam12852 101510010703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510010704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510010705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510010706 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 101510010707 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 101510010708 homotrimer interaction site [polypeptide binding]; other site 101510010709 putative active site [active] 101510010710 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 101510010711 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510010712 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 101510010713 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 101510010714 tandem repeat interface [polypeptide binding]; other site 101510010715 oligomer interface [polypeptide binding]; other site 101510010716 active site residues [active] 101510010717 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 101510010718 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 101510010719 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 101510010720 active site 101510010721 catalytic site [active] 101510010722 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 101510010723 Ferritin-like domain; Region: Ferritin; pfam00210 101510010724 ferroxidase diiron center [ion binding]; other site 101510010725 Secretory lipase; Region: LIP; pfam03583 101510010726 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 101510010727 Ferritin-like domain; Region: Ferritin; pfam00210 101510010728 ferroxidase diiron center [ion binding]; other site 101510010729 Transcriptional regulator [Transcription]; Region: LytR; COG1316 101510010730 CAAX protease self-immunity; Region: Abi; pfam02517 101510010731 prephenate dehydratase; Provisional; Region: PRK11898 101510010732 Prephenate dehydratase; Region: PDT; pfam00800 101510010733 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 101510010734 putative L-Phe binding site [chemical binding]; other site 101510010735 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510010736 catalytic core [active] 101510010737 Lipase maturation factor; Region: LMF1; pfam06762 101510010738 EspG family; Region: ESX-1_EspG; pfam14011 101510010739 PPE family; Region: PPE; pfam00823 101510010740 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 101510010741 Septum formation; Region: Septum_form; pfam13845 101510010742 Septum formation; Region: Septum_form; pfam13845 101510010743 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 101510010744 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 101510010745 seryl-tRNA synthetase; Provisional; Region: PRK05431 101510010746 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 101510010747 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 101510010748 dimer interface [polypeptide binding]; other site 101510010749 active site 101510010750 motif 1; other site 101510010751 motif 2; other site 101510010752 motif 3; other site 101510010753 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 101510010754 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 101510010755 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 101510010756 heme binding site [chemical binding]; other site 101510010757 ferroxidase pore; other site 101510010758 ferroxidase diiron center [ion binding]; other site 101510010759 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 101510010760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 101510010761 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510010762 iron-sulfur cluster [ion binding]; other site 101510010763 [2Fe-2S] cluster binding site [ion binding]; other site 101510010764 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 101510010765 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 101510010766 putative acyl-acceptor binding pocket; other site 101510010767 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 101510010768 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 101510010769 putative acyl-acceptor binding pocket; other site 101510010770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510010771 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 101510010772 active site 101510010773 motif I; other site 101510010774 motif II; other site 101510010775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510010776 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 101510010777 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 101510010778 amidase catalytic site [active] 101510010779 Zn binding residues [ion binding]; other site 101510010780 substrate binding site [chemical binding]; other site 101510010781 LGFP repeat; Region: LGFP; pfam08310 101510010782 Stage II sporulation protein; Region: SpoIID; pfam08486 101510010783 LGFP repeat; Region: LGFP; pfam08310 101510010784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510010785 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 101510010786 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 101510010787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510010788 UDP-galactopyranose mutase; Region: GLF; pfam03275 101510010789 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 101510010790 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510010791 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 101510010792 Putative esterase; Region: Esterase; pfam00756 101510010793 S-formylglutathione hydrolase; Region: PLN02442 101510010794 Predicted esterase [General function prediction only]; Region: COG0627 101510010795 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 101510010796 Putative esterase; Region: Esterase; pfam00756 101510010797 S-formylglutathione hydrolase; Region: PLN02442 101510010798 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 101510010799 LGFP repeat; Region: LGFP; pfam08310 101510010800 LGFP repeat; Region: LGFP; pfam08310 101510010801 LGFP repeat; Region: LGFP; pfam08310 101510010802 Cutinase; Region: Cutinase; pfam01083 101510010803 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 101510010804 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510010805 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 101510010806 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 101510010807 acyl-activating enzyme (AAE) consensus motif; other site 101510010808 active site 101510010809 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 101510010810 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 101510010811 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 101510010812 active site 101510010813 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 101510010814 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 101510010815 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 101510010816 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 101510010817 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510010818 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510010819 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 101510010820 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 101510010821 Transposase domain (DUF772); Region: DUF772; pfam05598 101510010822 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510010823 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510010824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510010825 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510010826 sequence-specific DNA binding site [nucleotide binding]; other site 101510010827 salt bridge; other site 101510010828 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 101510010829 active site 101510010830 MspA; Region: MspA; pfam09203 101510010831 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 101510010832 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 101510010833 short chain dehydrogenase; Provisional; Region: PRK07904 101510010834 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 101510010835 NAD(P) binding site [chemical binding]; other site 101510010836 active site 101510010837 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510010838 FAD binding domain; Region: FAD_binding_4; pfam01565 101510010839 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 101510010840 Predicted membrane protein [Function unknown]; Region: COG2246 101510010841 GtrA-like protein; Region: GtrA; pfam04138 101510010842 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 101510010843 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510010844 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 101510010845 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 101510010846 protein binding site [polypeptide binding]; other site 101510010847 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 101510010848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510010849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510010850 DNA binding site [nucleotide binding] 101510010851 domain linker motif; other site 101510010852 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 101510010853 dimerization interface [polypeptide binding]; other site 101510010854 ligand binding site [chemical binding]; other site 101510010855 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510010856 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510010857 Walker A/P-loop; other site 101510010858 ATP binding site [chemical binding]; other site 101510010859 Q-loop/lid; other site 101510010860 ABC transporter signature motif; other site 101510010861 Walker B; other site 101510010862 D-loop; other site 101510010863 H-loop/switch region; other site 101510010864 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510010865 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510010866 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510010867 TM-ABC transporter signature motif; other site 101510010868 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510010869 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510010870 TM-ABC transporter signature motif; other site 101510010871 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 101510010872 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 101510010873 ligand binding site [chemical binding]; other site 101510010874 Domain of unknown function (DUF718); Region: DUF718; pfam05336 101510010875 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 101510010876 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 101510010877 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 101510010878 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 101510010879 hexamer (dimer of trimers) interface [polypeptide binding]; other site 101510010880 trimer interface [polypeptide binding]; other site 101510010881 substrate binding site [chemical binding]; other site 101510010882 Mn binding site [ion binding]; other site 101510010883 short chain dehydrogenase; Validated; Region: PRK08324 101510010884 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 101510010885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510010886 NAD(P) binding site [chemical binding]; other site 101510010887 active site 101510010888 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 101510010889 N- and C-terminal domain interface [polypeptide binding]; other site 101510010890 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 101510010891 active site 101510010892 putative catalytic site [active] 101510010893 metal binding site [ion binding]; metal-binding site 101510010894 ATP binding site [chemical binding]; other site 101510010895 carbohydrate binding site [chemical binding]; other site 101510010896 enoyl-CoA hydratase; Provisional; Region: PRK05864 101510010897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510010898 substrate binding site [chemical binding]; other site 101510010899 oxyanion hole (OAH) forming residues; other site 101510010900 trimer interface [polypeptide binding]; other site 101510010901 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510010902 hydrophobic ligand binding site; other site 101510010903 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 101510010904 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 101510010905 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 101510010906 substrate binding site; other site 101510010907 tetramer interface; other site 101510010908 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 101510010909 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 101510010910 NAD binding site [chemical binding]; other site 101510010911 substrate binding site [chemical binding]; other site 101510010912 homodimer interface [polypeptide binding]; other site 101510010913 active site 101510010914 Methyltransferase domain; Region: Methyltransf_31; pfam13847 101510010915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510010916 S-adenosylmethionine binding site [chemical binding]; other site 101510010917 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 101510010918 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 101510010919 putative trimer interface [polypeptide binding]; other site 101510010920 putative CoA binding site [chemical binding]; other site 101510010921 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 101510010922 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 101510010923 inhibitor-cofactor binding pocket; inhibition site 101510010924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510010925 catalytic residue [active] 101510010926 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510010927 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510010928 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510010929 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 101510010930 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 101510010931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510010932 non-specific DNA binding site [nucleotide binding]; other site 101510010933 salt bridge; other site 101510010934 sequence-specific DNA binding site [nucleotide binding]; other site 101510010935 Cupin domain; Region: Cupin_2; pfam07883 101510010936 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 101510010937 active site 101510010938 catalytic triad [active] 101510010939 oxyanion hole [active] 101510010940 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 101510010941 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510010942 active site 101510010943 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 101510010944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510010945 active site 101510010946 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 101510010947 Methyltransferase domain; Region: Methyltransf_24; pfam13578 101510010948 GTPase RsgA; Reviewed; Region: PRK01889 101510010949 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 101510010950 GTPase/Zn-binding domain interface [polypeptide binding]; other site 101510010951 GTP/Mg2+ binding site [chemical binding]; other site 101510010952 G4 box; other site 101510010953 G5 box; other site 101510010954 G1 box; other site 101510010955 Switch I region; other site 101510010956 G2 box; other site 101510010957 G3 box; other site 101510010958 Switch II region; other site 101510010959 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 101510010960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510010961 active site 101510010962 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 101510010963 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 101510010964 Walker A/P-loop; other site 101510010965 ATP binding site [chemical binding]; other site 101510010966 Q-loop/lid; other site 101510010967 ABC transporter signature motif; other site 101510010968 Walker B; other site 101510010969 D-loop; other site 101510010970 H-loop/switch region; other site 101510010971 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 101510010972 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 101510010973 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 101510010974 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 101510010975 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510010976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510010977 catalytic residue [active] 101510010978 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 101510010979 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 101510010980 NAD(P) binding site [chemical binding]; other site 101510010981 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510010982 MarR family; Region: MarR_2; cl17246 101510010983 TfoX N-terminal domain; Region: TfoX_N; cl17592 101510010984 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510010985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510010986 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510010987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510010988 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 101510010989 putative hydrophobic ligand binding site [chemical binding]; other site 101510010990 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510010991 TIGR03086 family protein; Region: TIGR03086 101510010992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510010993 dimerization interface [polypeptide binding]; other site 101510010994 putative DNA binding site [nucleotide binding]; other site 101510010995 putative Zn2+ binding site [ion binding]; other site 101510010996 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510010997 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510010998 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 101510010999 Putative esterase; Region: Esterase; pfam00756 101510011000 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 101510011001 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 101510011002 putative active site [active] 101510011003 putative metal binding site [ion binding]; other site 101510011004 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 101510011005 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 101510011006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510011007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510011008 homodimer interface [polypeptide binding]; other site 101510011009 catalytic residue [active] 101510011010 Dienelactone hydrolase family; Region: DLH; pfam01738 101510011011 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 101510011012 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510011013 putative metal binding site [ion binding]; other site 101510011014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510011015 dimerization interface [polypeptide binding]; other site 101510011016 putative DNA binding site [nucleotide binding]; other site 101510011017 putative Zn2+ binding site [ion binding]; other site 101510011018 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510011019 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 101510011020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510011021 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 101510011022 putative dimerization interface [polypeptide binding]; other site 101510011023 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 101510011024 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 101510011025 NADP binding site [chemical binding]; other site 101510011026 homodimer interface [polypeptide binding]; other site 101510011027 active site 101510011028 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510011029 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510011030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011031 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510011032 putative substrate translocation pore; other site 101510011033 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 101510011034 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 101510011035 NAD binding site [chemical binding]; other site 101510011036 ligand binding site [chemical binding]; other site 101510011037 catalytic site [active] 101510011038 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 101510011039 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 101510011040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510011042 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510011043 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510011044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510011045 NmrA-like family; Region: NmrA; pfam05368 101510011046 NAD(P) binding site [chemical binding]; other site 101510011047 active site 101510011048 Domain of unknown function (DUF385); Region: DUF385; pfam04075 101510011049 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 101510011050 additional DNA contacts [nucleotide binding]; other site 101510011051 mismatch recognition site; other site 101510011052 active site 101510011053 zinc binding site [ion binding]; other site 101510011054 DNA intercalation site [nucleotide binding]; other site 101510011055 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 101510011056 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 101510011057 cofactor binding site; other site 101510011058 DNA binding site [nucleotide binding] 101510011059 substrate interaction site [chemical binding]; other site 101510011060 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 101510011061 prephenate dehydrogenase; Validated; Region: PRK06545 101510011062 prephenate dehydrogenase; Validated; Region: PRK08507 101510011063 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 101510011064 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 101510011065 nucleoside/Zn binding site; other site 101510011066 dimer interface [polypeptide binding]; other site 101510011067 catalytic motif [active] 101510011068 CsbD-like; Region: CsbD; pfam05532 101510011069 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510011070 classical (c) SDRs; Region: SDR_c; cd05233 101510011071 NAD(P) binding site [chemical binding]; other site 101510011072 active site 101510011073 YceI-like domain; Region: YceI; pfam04264 101510011074 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 101510011075 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 101510011076 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510011077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510011078 active site 101510011079 Predicted transcriptional regulator [Transcription]; Region: COG1959 101510011080 Transcriptional regulator; Region: Rrf2; pfam02082 101510011081 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510011082 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510011083 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510011084 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510011085 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510011086 FMN-binding pocket [chemical binding]; other site 101510011087 flavin binding motif; other site 101510011088 phosphate binding motif [ion binding]; other site 101510011089 beta-alpha-beta structure motif; other site 101510011090 NAD binding pocket [chemical binding]; other site 101510011091 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510011092 catalytic loop [active] 101510011093 iron binding site [ion binding]; other site 101510011094 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510011095 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510011096 iron-sulfur cluster [ion binding]; other site 101510011097 [2Fe-2S] cluster binding site [ion binding]; other site 101510011098 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510011099 hydrophobic ligand binding site; other site 101510011100 hypothetical protein; Provisional; Region: PRK08317 101510011101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510011102 S-adenosylmethionine binding site [chemical binding]; other site 101510011103 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 101510011104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011105 MMPL family; Region: MMPL; pfam03176 101510011106 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 101510011107 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 101510011108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510011109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510011110 Walker A/P-loop; other site 101510011111 ATP binding site [chemical binding]; other site 101510011112 Q-loop/lid; other site 101510011113 ABC transporter signature motif; other site 101510011114 Walker B; other site 101510011115 D-loop; other site 101510011116 H-loop/switch region; other site 101510011117 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 101510011118 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510011119 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 101510011120 Walker A/P-loop; other site 101510011121 ATP binding site [chemical binding]; other site 101510011122 Q-loop/lid; other site 101510011123 ABC transporter signature motif; other site 101510011124 Walker B; other site 101510011125 D-loop; other site 101510011126 H-loop/switch region; other site 101510011127 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 101510011128 Sulfatase; Region: Sulfatase; cl17466 101510011129 Sulfatase; Region: Sulfatase; cl17466 101510011130 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 101510011131 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 101510011132 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 101510011133 RDD family; Region: RDD; pfam06271 101510011134 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 101510011135 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 101510011136 active site 101510011137 HIGH motif; other site 101510011138 nucleotide binding site [chemical binding]; other site 101510011139 active site 101510011140 KMSKS motif; other site 101510011141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510011142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011143 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510011144 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 101510011145 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 101510011146 NADP+ binding site [chemical binding]; other site 101510011147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011148 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 101510011149 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 101510011150 putative acyl-acceptor binding pocket; other site 101510011151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510011152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011153 WHG domain; Region: WHG; pfam13305 101510011154 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 101510011155 putative active site [active] 101510011156 putative metal binding site [ion binding]; other site 101510011157 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510011158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510011159 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 101510011160 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 101510011161 Predicted membrane protein [Function unknown]; Region: COG3619 101510011162 Putative esterase; Region: Esterase; pfam00756 101510011163 S-formylglutathione hydrolase; Region: PLN02442 101510011164 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 101510011165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510011166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510011167 homodimer interface [polypeptide binding]; other site 101510011168 catalytic residue [active] 101510011169 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 101510011170 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 101510011171 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 101510011172 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 101510011173 intersubunit interface [polypeptide binding]; other site 101510011174 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 101510011175 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 101510011176 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 101510011177 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 101510011178 minor groove reading motif; other site 101510011179 helix-hairpin-helix signature motif; other site 101510011180 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 101510011181 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 101510011182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510011183 Walker A motif; other site 101510011184 ATP binding site [chemical binding]; other site 101510011185 Walker B motif; other site 101510011186 arginine finger; other site 101510011187 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 101510011188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510011189 Histidine kinase; Region: HisKA_3; pfam07730 101510011190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510011191 ATP binding site [chemical binding]; other site 101510011192 Mg2+ binding site [ion binding]; other site 101510011193 G-X-G motif; other site 101510011194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510011195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510011196 active site 101510011197 phosphorylation site [posttranslational modification] 101510011198 intermolecular recognition site; other site 101510011199 dimerization interface [polypeptide binding]; other site 101510011200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510011201 DNA binding residues [nucleotide binding] 101510011202 dimerization interface [polypeptide binding]; other site 101510011203 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 101510011204 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510011205 dimer interface [polypeptide binding]; other site 101510011206 active site 101510011207 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510011208 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510011209 substrate binding site [chemical binding]; other site 101510011210 oxyanion hole (OAH) forming residues; other site 101510011211 trimer interface [polypeptide binding]; other site 101510011212 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 101510011213 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510011214 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510011215 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 101510011216 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 101510011217 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 101510011218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510011219 S-adenosylmethionine binding site [chemical binding]; other site 101510011220 FAD binding domain; Region: FAD_binding_4; pfam01565 101510011221 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510011222 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 101510011223 hypothetical protein; Validated; Region: PRK00153 101510011224 recombination protein RecR; Reviewed; Region: recR; PRK00076 101510011225 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 101510011226 RecR protein; Region: RecR; pfam02132 101510011227 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 101510011228 putative active site [active] 101510011229 putative metal-binding site [ion binding]; other site 101510011230 tetramer interface [polypeptide binding]; other site 101510011231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510011232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510011235 dimerization interface [polypeptide binding]; other site 101510011236 putative DNA binding site [nucleotide binding]; other site 101510011237 putative Zn2+ binding site [ion binding]; other site 101510011238 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 101510011239 putative hydrophobic ligand binding site [chemical binding]; other site 101510011240 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 101510011241 catalytic triad [active] 101510011242 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 101510011243 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 101510011244 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 101510011245 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 101510011246 EamA-like transporter family; Region: EamA; pfam00892 101510011247 EamA-like transporter family; Region: EamA; pfam00892 101510011248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510011249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510011250 putative DNA binding site [nucleotide binding]; other site 101510011251 putative Zn2+ binding site [ion binding]; other site 101510011252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510011253 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 101510011254 Short C-terminal domain; Region: SHOCT; pfam09851 101510011255 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 101510011256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510011257 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510011258 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 101510011259 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510011260 carboxyltransferase (CT) interaction site; other site 101510011261 biotinylation site [posttranslational modification]; other site 101510011262 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 101510011263 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 101510011264 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 101510011265 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 101510011266 D-pathway; other site 101510011267 Putative ubiquinol binding site [chemical binding]; other site 101510011268 Low-spin heme (heme b) binding site [chemical binding]; other site 101510011269 Putative water exit pathway; other site 101510011270 Binuclear center (heme o3/CuB) [ion binding]; other site 101510011271 K-pathway; other site 101510011272 Putative proton exit pathway; other site 101510011273 2-isopropylmalate synthase; Validated; Region: PRK03739 101510011274 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 101510011275 active site 101510011276 catalytic residues [active] 101510011277 metal binding site [ion binding]; metal-binding site 101510011278 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 101510011279 Pirin-related protein [General function prediction only]; Region: COG1741 101510011280 Pirin; Region: Pirin; pfam02678 101510011281 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 101510011282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510011283 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510011284 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510011285 Protein of unknown function (DUF732); Region: DUF732; pfam05305 101510011286 Erythronolide synthase docking; Region: Docking; pfam08990 101510011287 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 101510011288 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 101510011289 active site 101510011290 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 101510011291 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 101510011292 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 101510011293 putative NADP binding site [chemical binding]; other site 101510011294 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 101510011295 active site 101510011296 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 101510011297 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 101510011298 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 101510011299 active site 101510011300 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 101510011301 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 101510011302 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 101510011303 putative NADP binding site [chemical binding]; other site 101510011304 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 101510011305 active site 101510011306 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 101510011307 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 101510011308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510011309 S-adenosylmethionine binding site [chemical binding]; other site 101510011310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510011311 putative DNA binding site [nucleotide binding]; other site 101510011312 Predicted transcriptional regulator [Transcription]; Region: COG2345 101510011313 putative Zn2+ binding site [ion binding]; other site 101510011314 DoxX; Region: DoxX; cl17842 101510011315 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 101510011316 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 101510011317 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 101510011318 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510011319 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 101510011320 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 101510011321 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 101510011322 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 101510011323 metal binding site [ion binding]; metal-binding site 101510011324 putative dimer interface [polypeptide binding]; other site 101510011325 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 101510011326 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 101510011327 siderophore binding site; other site 101510011328 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 101510011329 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 101510011330 putative hydrophobic ligand binding site [chemical binding]; other site 101510011331 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510011332 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510011333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510011334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510011335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 101510011336 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510011337 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510011338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 101510011339 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 101510011340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510011341 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 101510011342 Cation efflux family; Region: Cation_efflux; cl00316 101510011343 enoyl-CoA hydratase; Provisional; Region: PRK12478 101510011344 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510011345 substrate binding site [chemical binding]; other site 101510011346 oxyanion hole (OAH) forming residues; other site 101510011347 trimer interface [polypeptide binding]; other site 101510011348 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 101510011349 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510011350 active site 101510011351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510011352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011353 enoyl-CoA hydratase; Provisional; Region: PRK08290 101510011354 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510011355 substrate binding site [chemical binding]; other site 101510011356 oxyanion hole (OAH) forming residues; other site 101510011357 trimer interface [polypeptide binding]; other site 101510011358 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 101510011359 active site 101510011360 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510011361 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 101510011362 nucleophilic elbow; other site 101510011363 catalytic triad; other site 101510011364 short chain dehydrogenase; Provisional; Region: PRK06197 101510011365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510011366 NAD(P) binding site [chemical binding]; other site 101510011367 active site 101510011368 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 101510011369 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510011370 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510011371 FMN-binding pocket [chemical binding]; other site 101510011372 flavin binding motif; other site 101510011373 phosphate binding motif [ion binding]; other site 101510011374 beta-alpha-beta structure motif; other site 101510011375 NAD binding pocket [chemical binding]; other site 101510011376 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510011377 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510011378 catalytic loop [active] 101510011379 iron binding site [ion binding]; other site 101510011380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510011381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011382 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 101510011383 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 101510011384 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 101510011385 Ligand binding site; other site 101510011386 Putative Catalytic site; other site 101510011387 DXD motif; other site 101510011388 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 101510011389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510011390 NAD(P) binding site [chemical binding]; other site 101510011391 active site 101510011392 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 101510011393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510011394 S-adenosylmethionine binding site [chemical binding]; other site 101510011395 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 101510011396 Moco binding site; other site 101510011397 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 101510011398 metal coordination site [ion binding]; other site 101510011399 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 101510011400 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510011401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011402 putative substrate translocation pore; other site 101510011403 Short C-terminal domain; Region: SHOCT; pfam09851 101510011404 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 101510011405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510011406 dimer interface [polypeptide binding]; other site 101510011407 conserved gate region; other site 101510011408 putative PBP binding loops; other site 101510011409 ABC-ATPase subunit interface; other site 101510011410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510011411 dimer interface [polypeptide binding]; other site 101510011412 conserved gate region; other site 101510011413 putative PBP binding loops; other site 101510011414 ABC-ATPase subunit interface; other site 101510011415 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 101510011416 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 101510011417 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 101510011418 active site 101510011419 catalytic site [active] 101510011420 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510011421 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510011422 DNA binding site [nucleotide binding] 101510011423 domain linker motif; other site 101510011424 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 101510011425 ligand binding site [chemical binding]; other site 101510011426 dimerization interface [polypeptide binding]; other site 101510011427 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 101510011428 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 101510011429 Walker A/P-loop; other site 101510011430 ATP binding site [chemical binding]; other site 101510011431 Q-loop/lid; other site 101510011432 ABC transporter signature motif; other site 101510011433 Walker B; other site 101510011434 D-loop; other site 101510011435 H-loop/switch region; other site 101510011436 TOBE domain; Region: TOBE_2; pfam08402 101510011437 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 101510011438 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 101510011439 nucleotide binding site [chemical binding]; other site 101510011440 Transcription factor WhiB; Region: Whib; pfam02467 101510011441 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510011442 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510011443 active site 101510011444 ATP binding site [chemical binding]; other site 101510011445 substrate binding site [chemical binding]; other site 101510011446 activation loop (A-loop); other site 101510011447 Uncharacterized conserved protein [Function unknown]; Region: COG3391 101510011448 NHL repeat; Region: NHL; pfam01436 101510011449 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 101510011450 AAA ATPase domain; Region: AAA_16; pfam13191 101510011451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510011452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510011453 DNA binding residues [nucleotide binding] 101510011454 dimerization interface [polypeptide binding]; other site 101510011455 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510011456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510011457 active site 101510011458 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 101510011459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510011460 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 101510011461 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 101510011462 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 101510011463 Sulfate transporter family; Region: Sulfate_transp; pfam00916 101510011464 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 101510011465 Uncharacterized conserved protein [Function unknown]; Region: COG5361 101510011466 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 101510011467 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 101510011468 Predicted membrane protein [Function unknown]; Region: COG4325 101510011469 aspartate kinase; Reviewed; Region: PRK06635 101510011470 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 101510011471 putative nucleotide binding site [chemical binding]; other site 101510011472 putative catalytic residues [active] 101510011473 putative Mg ion binding site [ion binding]; other site 101510011474 putative aspartate binding site [chemical binding]; other site 101510011475 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 101510011476 putative allosteric regulatory site; other site 101510011477 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 101510011478 putative allosteric regulatory residue; other site 101510011479 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 101510011480 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510011481 Helix-turn-helix domain; Region: HTH_38; pfam13936 101510011482 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 101510011483 Integrase core domain; Region: rve; pfam00665 101510011484 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 101510011485 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 101510011486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510011487 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 101510011488 active site 101510011489 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510011490 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510011491 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 101510011492 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510011493 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510011494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510011495 DNA-binding site [nucleotide binding]; DNA binding site 101510011496 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 101510011497 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 101510011498 Uncharacterized conserved protein [Function unknown]; Region: COG1262 101510011499 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 101510011500 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 101510011501 Multicopper oxidase; Region: Cu-oxidase; pfam00394 101510011502 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 101510011503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510011504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011505 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510011506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510011507 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 101510011508 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510011509 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 101510011510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510011511 putative DNA binding site [nucleotide binding]; other site 101510011512 putative Zn2+ binding site [ion binding]; other site 101510011513 ferric uptake regulator; Provisional; Region: fur; PRK09462 101510011514 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 101510011515 metal binding site 2 [ion binding]; metal-binding site 101510011516 putative DNA binding helix; other site 101510011517 metal binding site 1 [ion binding]; metal-binding site 101510011518 dimer interface [polypeptide binding]; other site 101510011519 structural Zn2+ binding site [ion binding]; other site 101510011520 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 101510011521 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 101510011522 tetramer interface [polypeptide binding]; other site 101510011523 heme binding pocket [chemical binding]; other site 101510011524 NADPH binding site [chemical binding]; other site 101510011525 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 101510011526 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 101510011527 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 101510011528 siderophore binding site; other site 101510011529 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 101510011530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 101510011531 putative active site [active] 101510011532 putative metal binding site [ion binding]; other site 101510011533 Yqey-like protein; Region: YqeY; pfam09424 101510011534 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 101510011535 Transglycosylase; Region: Transgly; pfam00912 101510011536 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 101510011537 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 101510011538 Transcription factor WhiB; Region: Whib; pfam02467 101510011539 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 101510011540 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 101510011541 DTAP/Switch II; other site 101510011542 Switch I; other site 101510011543 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 101510011544 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 101510011545 P loop; other site 101510011546 Nucleotide binding site [chemical binding]; other site 101510011547 DTAP/Switch II; other site 101510011548 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 101510011549 homotrimer interaction site [polypeptide binding]; other site 101510011550 putative active site [active] 101510011551 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 101510011552 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 101510011553 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 101510011554 ligand binding site [chemical binding]; other site 101510011555 flexible hinge region; other site 101510011556 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 101510011557 putative switch regulator; other site 101510011558 non-specific DNA interactions [nucleotide binding]; other site 101510011559 DNA binding site [nucleotide binding] 101510011560 sequence specific DNA binding site [nucleotide binding]; other site 101510011561 putative cAMP binding site [chemical binding]; other site 101510011562 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 101510011563 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 101510011564 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 101510011565 minor groove reading motif; other site 101510011566 helix-hairpin-helix signature motif; other site 101510011567 substrate binding pocket [chemical binding]; other site 101510011568 active site 101510011569 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 101510011570 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 101510011571 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 101510011572 catalytic residues [active] 101510011573 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 101510011574 putative active site [active] 101510011575 putative CoA binding site [chemical binding]; other site 101510011576 nudix motif; other site 101510011577 metal binding site [ion binding]; metal-binding site 101510011578 Colicin V production protein; Region: Colicin_V; pfam02674 101510011579 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 101510011580 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 101510011581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510011582 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510011583 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 101510011584 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 101510011585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011586 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510011587 putative substrate translocation pore; other site 101510011588 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 101510011589 cyclase homology domain; Region: CHD; cd07302 101510011590 nucleotidyl binding site; other site 101510011591 metal binding site [ion binding]; metal-binding site 101510011592 dimer interface [polypeptide binding]; other site 101510011593 acetyl-CoA synthetase; Provisional; Region: PRK00174 101510011594 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 101510011595 active site 101510011596 CoA binding site [chemical binding]; other site 101510011597 acyl-activating enzyme (AAE) consensus motif; other site 101510011598 AMP binding site [chemical binding]; other site 101510011599 acetate binding site [chemical binding]; other site 101510011600 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 101510011601 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 101510011602 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 101510011603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510011604 dimer interface [polypeptide binding]; other site 101510011605 conserved gate region; other site 101510011606 putative PBP binding loops; other site 101510011607 ABC-ATPase subunit interface; other site 101510011608 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 101510011609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510011610 dimer interface [polypeptide binding]; other site 101510011611 conserved gate region; other site 101510011612 putative PBP binding loops; other site 101510011613 ABC-ATPase subunit interface; other site 101510011614 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 101510011615 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510011616 Walker A/P-loop; other site 101510011617 ATP binding site [chemical binding]; other site 101510011618 Q-loop/lid; other site 101510011619 ABC transporter signature motif; other site 101510011620 Walker B; other site 101510011621 D-loop; other site 101510011622 H-loop/switch region; other site 101510011623 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510011624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510011625 Walker A/P-loop; other site 101510011626 ATP binding site [chemical binding]; other site 101510011627 Q-loop/lid; other site 101510011628 ABC transporter signature motif; other site 101510011629 Walker B; other site 101510011630 D-loop; other site 101510011631 H-loop/switch region; other site 101510011632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510011633 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 101510011634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510011635 motif II; other site 101510011636 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 101510011637 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 101510011638 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 101510011639 Walker A motif; other site 101510011640 hexamer interface [polypeptide binding]; other site 101510011641 ATP binding site [chemical binding]; other site 101510011642 Walker B motif; other site 101510011643 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 101510011644 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 101510011645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011646 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510011647 putative substrate translocation pore; other site 101510011648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510011649 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 101510011650 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510011651 dimerization interface [polypeptide binding]; other site 101510011652 substrate binding pocket [chemical binding]; other site 101510011653 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 101510011654 Coenzyme A transferase; Region: CoA_trans; cl17247 101510011655 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 101510011656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510011657 ATP binding site [chemical binding]; other site 101510011658 putative Mg++ binding site [ion binding]; other site 101510011659 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 101510011660 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 101510011661 DNA-binding site [nucleotide binding]; DNA binding site 101510011662 RNA-binding motif; other site 101510011663 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 101510011664 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 101510011665 active site 101510011666 interdomain interaction site; other site 101510011667 putative metal-binding site [ion binding]; other site 101510011668 nucleotide binding site [chemical binding]; other site 101510011669 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 101510011670 domain I; other site 101510011671 phosphate binding site [ion binding]; other site 101510011672 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 101510011673 domain II; other site 101510011674 domain III; other site 101510011675 nucleotide binding site [chemical binding]; other site 101510011676 DNA binding groove [nucleotide binding] 101510011677 catalytic site [active] 101510011678 domain IV; other site 101510011679 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 101510011680 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 101510011681 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 101510011682 DNA polymerase III subunit delta'; Validated; Region: PRK07940 101510011683 DNA polymerase III subunit delta'; Validated; Region: PRK08485 101510011684 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 101510011685 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 101510011686 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510011687 substrate binding pocket [chemical binding]; other site 101510011688 membrane-bound complex binding site; other site 101510011689 hinge residues; other site 101510011690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510011691 dimer interface [polypeptide binding]; other site 101510011692 conserved gate region; other site 101510011693 putative PBP binding loops; other site 101510011694 ABC-ATPase subunit interface; other site 101510011695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510011696 dimer interface [polypeptide binding]; other site 101510011697 conserved gate region; other site 101510011698 putative PBP binding loops; other site 101510011699 ABC-ATPase subunit interface; other site 101510011700 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510011701 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510011702 Walker A/P-loop; other site 101510011703 ATP binding site [chemical binding]; other site 101510011704 Q-loop/lid; other site 101510011705 ABC transporter signature motif; other site 101510011706 Walker B; other site 101510011707 D-loop; other site 101510011708 H-loop/switch region; other site 101510011709 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 101510011710 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 101510011711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510011712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510011713 LysR substrate binding domain; Region: LysR_substrate; pfam03466 101510011714 dimerization interface [polypeptide binding]; other site 101510011715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011716 putative substrate translocation pore; other site 101510011717 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 101510011718 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510011719 Domain of unknown function (DUF336); Region: DUF336; pfam03928 101510011720 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 101510011721 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510011722 iron-sulfur cluster [ion binding]; other site 101510011723 [2Fe-2S] cluster binding site [ion binding]; other site 101510011724 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510011725 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510011726 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510011727 NAD(P) binding site [chemical binding]; other site 101510011728 catalytic residues [active] 101510011729 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 101510011730 [2Fe-2S] cluster binding site [ion binding]; other site 101510011731 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 101510011732 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 101510011733 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 101510011734 homotrimer interaction site [polypeptide binding]; other site 101510011735 putative active site [active] 101510011736 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510011737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510011738 DNA-binding site [nucleotide binding]; DNA binding site 101510011739 FCD domain; Region: FCD; pfam07729 101510011740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011741 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 101510011742 Zn binding site [ion binding]; other site 101510011743 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510011744 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510011745 acyl-activating enzyme (AAE) consensus motif; other site 101510011746 AMP binding site [chemical binding]; other site 101510011747 active site 101510011748 CoA binding site [chemical binding]; other site 101510011749 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510011750 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 101510011751 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 101510011752 putative trimer interface [polypeptide binding]; other site 101510011753 putative CoA binding site [chemical binding]; other site 101510011754 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 101510011755 putative trimer interface [polypeptide binding]; other site 101510011756 putative CoA binding site [chemical binding]; other site 101510011757 YCII-related domain; Region: YCII; cl00999 101510011758 YCII-related domain; Region: YCII; cl00999 101510011759 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 101510011760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510011761 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 101510011762 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 101510011763 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 101510011764 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510011765 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 101510011766 active site 101510011767 catalytic triad [active] 101510011768 dimer interface [polypeptide binding]; other site 101510011769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510011770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011771 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510011772 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510011773 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 101510011774 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510011775 mce related protein; Region: MCE; pfam02470 101510011776 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 101510011777 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510011778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510011779 catalytic residue [active] 101510011780 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510011781 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510011782 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 101510011783 putative deacylase active site [active] 101510011784 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 101510011785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510011786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510011787 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510011788 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510011789 enoyl-CoA hydratase; Provisional; Region: PRK06142 101510011790 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510011791 substrate binding site [chemical binding]; other site 101510011792 oxyanion hole (OAH) forming residues; other site 101510011793 trimer interface [polypeptide binding]; other site 101510011794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011795 putative substrate translocation pore; other site 101510011796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510011797 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 101510011798 dimer interface [polypeptide binding]; other site 101510011799 substrate binding site [chemical binding]; other site 101510011800 metal binding sites [ion binding]; metal-binding site 101510011801 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 101510011802 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 101510011803 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 101510011804 putative hydrolase; Region: TIGR03624 101510011805 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 101510011806 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 101510011807 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510011808 active site 101510011809 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510011810 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510011811 active site 101510011812 ATP binding site [chemical binding]; other site 101510011813 substrate binding site [chemical binding]; other site 101510011814 activation loop (A-loop); other site 101510011815 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 101510011816 Amidase; Region: Amidase; cl11426 101510011817 FtsH Extracellular; Region: FtsH_ext; pfam06480 101510011818 Poxvirus virion envelope protein A14; Region: Pox_A14; cl17336 101510011819 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 101510011820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510011821 Walker A motif; other site 101510011822 ATP binding site [chemical binding]; other site 101510011823 Walker B motif; other site 101510011824 arginine finger; other site 101510011825 Peptidase family M41; Region: Peptidase_M41; pfam01434 101510011826 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 101510011827 homodecamer interface [polypeptide binding]; other site 101510011828 GTP cyclohydrolase I; Provisional; Region: PLN03044 101510011829 active site 101510011830 putative catalytic site residues [active] 101510011831 zinc binding site [ion binding]; other site 101510011832 GTP-CH-I/GFRP interaction surface; other site 101510011833 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 101510011834 dihydropteroate synthase; Region: DHPS; TIGR01496 101510011835 substrate binding pocket [chemical binding]; other site 101510011836 dimer interface [polypeptide binding]; other site 101510011837 inhibitor binding site; inhibition site 101510011838 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 101510011839 active site 101510011840 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 101510011841 catalytic center binding site [active] 101510011842 ATP binding site [chemical binding]; other site 101510011843 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 101510011844 Uncharacterized conserved protein [Function unknown]; Region: COG5495 101510011845 Rossmann-like domain; Region: Rossmann-like; pfam10727 101510011846 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 101510011847 pantoate--beta-alanine ligase; Region: panC; TIGR00018 101510011848 Pantoate-beta-alanine ligase; Region: PanC; cd00560 101510011849 active site 101510011850 ATP-binding site [chemical binding]; other site 101510011851 pantoate-binding site; other site 101510011852 HXXH motif; other site 101510011853 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 101510011854 tetramerization interface [polypeptide binding]; other site 101510011855 active site 101510011856 pantothenate kinase; Reviewed; Region: PRK13318 101510011857 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 101510011858 Rhodanese Homology Domain; Region: RHOD; smart00450 101510011859 active site residue [active] 101510011860 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 101510011861 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 101510011862 dimer interface [polypeptide binding]; other site 101510011863 putative anticodon binding site; other site 101510011864 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 101510011865 motif 1; other site 101510011866 dimer interface [polypeptide binding]; other site 101510011867 active site 101510011868 motif 2; other site 101510011869 motif 3; other site 101510011870 Lsr2; Region: Lsr2; pfam11774 101510011871 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 101510011872 Lipase (class 2); Region: Lipase_2; pfam01674 101510011873 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 101510011874 Clp amino terminal domain; Region: Clp_N; pfam02861 101510011875 Clp amino terminal domain; Region: Clp_N; pfam02861 101510011876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510011877 Walker A motif; other site 101510011878 ATP binding site [chemical binding]; other site 101510011879 Walker B motif; other site 101510011880 arginine finger; other site 101510011881 UvrB/uvrC motif; Region: UVR; pfam02151 101510011882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510011883 Walker A motif; other site 101510011884 ATP binding site [chemical binding]; other site 101510011885 Walker B motif; other site 101510011886 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 101510011887 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510011888 TIGR03086 family protein; Region: TIGR03086 101510011889 Predicted transcriptional regulator [Transcription]; Region: COG2378 101510011890 HTH domain; Region: HTH_11; pfam08279 101510011891 WYL domain; Region: WYL; pfam13280 101510011892 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 101510011893 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 101510011894 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 101510011895 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 101510011896 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 101510011897 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 101510011898 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 101510011899 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 101510011900 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 101510011901 catalytic residues [active] 101510011902 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 101510011903 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 101510011904 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510011905 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510011906 catalytic site [active] 101510011907 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 101510011908 Helix-turn-helix domain; Region: HTH_17; pfam12728 101510011909 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 101510011910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510011911 S-adenosylmethionine binding site [chemical binding]; other site 101510011912 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 101510011913 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 101510011914 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 101510011915 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 101510011916 homodimer interface [polypeptide binding]; other site 101510011917 substrate-cofactor binding pocket; other site 101510011918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510011919 catalytic residue [active] 101510011920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510011921 Walker A/P-loop; other site 101510011922 ATP binding site [chemical binding]; other site 101510011923 Q-loop/lid; other site 101510011924 ABC transporter signature motif; other site 101510011925 Walker B; other site 101510011926 D-loop; other site 101510011927 H-loop/switch region; other site 101510011928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510011929 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510011930 Walker A/P-loop; other site 101510011931 ATP binding site [chemical binding]; other site 101510011932 Q-loop/lid; other site 101510011933 ABC transporter signature motif; other site 101510011934 Walker B; other site 101510011935 D-loop; other site 101510011936 H-loop/switch region; other site 101510011937 Cupin domain; Region: Cupin_2; pfam07883 101510011938 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 101510011939 O-methyltransferase; Region: Methyltransf_2; pfam00891 101510011940 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 101510011941 endonuclease III; Region: ENDO3c; smart00478 101510011942 minor groove reading motif; other site 101510011943 helix-hairpin-helix signature motif; other site 101510011944 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 101510011945 active site clefts [active] 101510011946 zinc binding site [ion binding]; other site 101510011947 dimer interface [polypeptide binding]; other site 101510011948 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 101510011949 active site 101510011950 homotetramer interface [polypeptide binding]; other site 101510011951 homodimer interface [polypeptide binding]; other site 101510011952 L-asparagine permease; Provisional; Region: PRK15049 101510011953 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 101510011954 Aspartase; Region: Aspartase; cd01357 101510011955 active sites [active] 101510011956 tetramer interface [polypeptide binding]; other site 101510011957 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510011958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510011959 DNA-binding site [nucleotide binding]; DNA binding site 101510011960 FCD domain; Region: FCD; pfam07729 101510011961 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 101510011962 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 101510011963 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 101510011964 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510011965 CoenzymeA binding site [chemical binding]; other site 101510011966 subunit interaction site [polypeptide binding]; other site 101510011967 PHB binding site; other site 101510011968 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 101510011969 DNA repair protein RadA; Provisional; Region: PRK11823 101510011970 Walker A motif; other site 101510011971 ATP binding site [chemical binding]; other site 101510011972 Walker B motif; other site 101510011973 Protein of unknown function (DUF461); Region: DUF461; cl01071 101510011974 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 101510011975 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 101510011976 substrate binding site; other site 101510011977 dimer interface; other site 101510011978 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 101510011979 homotrimer interaction site [polypeptide binding]; other site 101510011980 zinc binding site [ion binding]; other site 101510011981 CDP-binding sites; other site 101510011982 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 101510011983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 101510011984 active site 101510011985 HIGH motif; other site 101510011986 nucleotide binding site [chemical binding]; other site 101510011987 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 101510011988 KMSKS motif; other site 101510011989 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 101510011990 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 101510011991 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 101510011992 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 101510011993 Fatty acid desaturase; Region: FA_desaturase; pfam00487 101510011994 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 101510011995 putative di-iron ligands [ion binding]; other site 101510011996 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 101510011997 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 101510011998 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 101510011999 hexamer interface [polypeptide binding]; other site 101510012000 ligand binding site [chemical binding]; other site 101510012001 putative active site [active] 101510012002 NAD(P) binding site [chemical binding]; other site 101510012003 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 101510012004 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510012005 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 101510012006 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 101510012007 tetrameric interface [polypeptide binding]; other site 101510012008 NAD binding site [chemical binding]; other site 101510012009 catalytic residues [active] 101510012010 hypothetical protein; Provisional; Region: PRK06062 101510012011 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510012012 inhibitor-cofactor binding pocket; inhibition site 101510012013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510012014 catalytic residue [active] 101510012015 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 101510012016 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 101510012017 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 101510012018 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 101510012019 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 101510012020 putative active site [active] 101510012021 EspG family; Region: ESX-1_EspG; pfam14011 101510012022 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 101510012023 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 101510012024 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 101510012025 dimer interface [polypeptide binding]; other site 101510012026 putative PBP binding regions; other site 101510012027 ABC-ATPase subunit interface; other site 101510012028 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 101510012029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510012030 Walker A/P-loop; other site 101510012031 ATP binding site [chemical binding]; other site 101510012032 Q-loop/lid; other site 101510012033 ABC transporter signature motif; other site 101510012034 Walker B; other site 101510012035 D-loop; other site 101510012036 H-loop/switch region; other site 101510012037 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 101510012038 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 101510012039 intersubunit interface [polypeptide binding]; other site 101510012040 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510012041 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510012042 DNA binding site [nucleotide binding] 101510012043 domain linker motif; other site 101510012044 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 101510012045 putative dimerization interface [polypeptide binding]; other site 101510012046 putative ligand binding site [chemical binding]; other site 101510012047 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 101510012048 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 101510012049 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 101510012050 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 101510012051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510012052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012054 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510012055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012056 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012057 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012058 active site 101510012059 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012061 active site 101510012062 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012063 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012064 active site 101510012065 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 101510012066 active site 101510012067 catalytic site [active] 101510012068 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 101510012069 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510012070 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510012071 active site 2 [active] 101510012072 active site 1 [active] 101510012073 lipid-transfer protein; Provisional; Region: PRK07855 101510012074 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510012075 active site 101510012076 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 101510012077 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 101510012078 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 101510012079 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 101510012080 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 101510012081 acyl-activating enzyme (AAE) consensus motif; other site 101510012082 putative AMP binding site [chemical binding]; other site 101510012083 putative active site [active] 101510012084 putative CoA binding site [chemical binding]; other site 101510012085 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510012086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510012087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510012088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510012089 DNA binding residues [nucleotide binding] 101510012090 dimerization interface [polypeptide binding]; other site 101510012091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510012092 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 101510012093 Walker A/P-loop; other site 101510012094 ATP binding site [chemical binding]; other site 101510012095 Q-loop/lid; other site 101510012096 ABC transporter signature motif; other site 101510012097 Walker B; other site 101510012098 D-loop; other site 101510012099 H-loop/switch region; other site 101510012100 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 101510012101 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510012102 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 101510012103 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 101510012104 Ligand binding site; other site 101510012105 metal-binding site 101510012106 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 101510012107 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510012108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510012109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510012110 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 101510012111 dimerization interface [polypeptide binding]; other site 101510012112 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510012113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510012114 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 101510012115 nudix motif; other site 101510012116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 101510012117 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510012118 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510012119 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 101510012120 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 101510012121 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 101510012122 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 101510012123 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 101510012124 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 101510012125 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 101510012126 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 101510012127 active site 101510012128 putative substrate binding pocket [chemical binding]; other site 101510012129 urate oxidase; Region: urate_oxi; TIGR03383 101510012130 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 101510012131 active site 101510012132 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 101510012133 active site 101510012134 homotetramer interface [polypeptide binding]; other site 101510012135 putative OHCU decarboxylase; Provisional; Region: PRK13798 101510012136 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 101510012137 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510012138 active site 101510012139 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 101510012140 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510012141 oxidase reductase; Provisional; Region: PTZ00273 101510012142 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 101510012143 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 101510012144 xanthine permease; Region: pbuX; TIGR03173 101510012145 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 101510012146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510012147 non-specific DNA binding site [nucleotide binding]; other site 101510012148 salt bridge; other site 101510012149 sequence-specific DNA binding site [nucleotide binding]; other site 101510012150 Cupin domain; Region: Cupin_2; pfam07883 101510012151 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 101510012152 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 101510012153 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 101510012154 Na binding site [ion binding]; other site 101510012155 putative substrate binding site [chemical binding]; other site 101510012156 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510012157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510012158 DNA-binding site [nucleotide binding]; DNA binding site 101510012159 FCD domain; Region: FCD; pfam07729 101510012160 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 101510012161 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 101510012162 active site 101510012163 catalytic site [active] 101510012164 tetramer interface [polypeptide binding]; other site 101510012165 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510012166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 101510012167 Predicted ATPase [General function prediction only]; Region: COG1485 101510012168 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 101510012169 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 101510012170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510012171 catalytic residue [active] 101510012172 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 101510012173 MoxR-like ATPases [General function prediction only]; Region: COG0714 101510012174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510012175 Walker A motif; other site 101510012176 ATP binding site [chemical binding]; other site 101510012177 Walker B motif; other site 101510012178 arginine finger; other site 101510012179 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 101510012180 Protein of unknown function DUF58; Region: DUF58; pfam01882 101510012181 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510012182 NlpC/P60 family; Region: NLPC_P60; pfam00877 101510012183 enoyl-CoA hydratase; Region: PLN02864 101510012184 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 101510012185 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 101510012186 dimer interaction site [polypeptide binding]; other site 101510012187 substrate-binding tunnel; other site 101510012188 active site 101510012189 catalytic site [active] 101510012190 substrate binding site [chemical binding]; other site 101510012191 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 101510012192 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510012193 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 101510012194 acetaldehyde dehydrogenase; Validated; Region: PRK08300 101510012195 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510012196 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 101510012197 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 101510012198 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 101510012199 active site 101510012200 catalytic residues [active] 101510012201 metal binding site [ion binding]; metal-binding site 101510012202 DmpG-like communication domain; Region: DmpG_comm; pfam07836 101510012203 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510012204 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510012205 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510012206 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 101510012207 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 101510012208 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012209 Flavin binding site [chemical binding]; other site 101510012210 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 101510012211 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510012212 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 101510012213 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 101510012214 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 101510012215 active site 101510012216 Fe binding site [ion binding]; other site 101510012217 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510012218 succinic semialdehyde dehydrogenase; Region: PLN02278 101510012219 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 101510012220 tetramerization interface [polypeptide binding]; other site 101510012221 NAD(P) binding site [chemical binding]; other site 101510012222 catalytic residues [active] 101510012223 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 101510012224 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510012225 inhibitor-cofactor binding pocket; inhibition site 101510012226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510012227 catalytic residue [active] 101510012228 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 101510012229 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 101510012230 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 101510012231 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 101510012232 putative active site [active] 101510012233 metal binding site [ion binding]; metal-binding site 101510012234 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 101510012235 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 101510012236 tetrameric interface [polypeptide binding]; other site 101510012237 NAD binding site [chemical binding]; other site 101510012238 catalytic residues [active] 101510012239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510012240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510012241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510012242 dimerization interface [polypeptide binding]; other site 101510012243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510012244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510012245 DNA binding site [nucleotide binding] 101510012246 domain linker motif; other site 101510012247 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 101510012248 putative dimerization interface [polypeptide binding]; other site 101510012249 putative ligand binding site [chemical binding]; other site 101510012250 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510012251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510012252 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510012253 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 101510012254 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 101510012255 Metal-binding active site; metal-binding site 101510012256 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 101510012257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510012258 PYR/PP interface [polypeptide binding]; other site 101510012259 dimer interface [polypeptide binding]; other site 101510012260 TPP binding site [chemical binding]; other site 101510012261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510012262 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 101510012263 TPP-binding site [chemical binding]; other site 101510012264 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 101510012265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510012266 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510012267 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 101510012268 Aspartase; Region: Aspartase; cd01357 101510012269 active sites [active] 101510012270 tetramer interface [polypeptide binding]; other site 101510012271 histidinol dehydrogenase; Region: hisD; TIGR00069 101510012272 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 101510012273 NAD binding site [chemical binding]; other site 101510012274 dimerization interface [polypeptide binding]; other site 101510012275 product binding site; other site 101510012276 substrate binding site [chemical binding]; other site 101510012277 zinc binding site [ion binding]; other site 101510012278 catalytic residues [active] 101510012279 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 101510012280 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510012281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510012282 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510012283 putative substrate translocation pore; other site 101510012284 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 101510012285 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510012286 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 101510012287 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510012288 PYR/PP interface [polypeptide binding]; other site 101510012289 dimer interface [polypeptide binding]; other site 101510012290 TPP binding site [chemical binding]; other site 101510012291 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510012292 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 101510012293 TPP-binding site [chemical binding]; other site 101510012294 Trehalose utilisation; Region: ThuA; pfam06283 101510012295 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510012296 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510012297 DNA binding site [nucleotide binding] 101510012298 domain linker motif; other site 101510012299 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 101510012300 putative dimerization interface [polypeptide binding]; other site 101510012301 putative ligand binding site [chemical binding]; other site 101510012302 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 101510012303 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510012304 Proline racemase; Region: Pro_racemase; pfam05544 101510012305 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 101510012306 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 101510012307 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 101510012308 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 101510012309 Sulfatase; Region: Sulfatase; pfam00884 101510012310 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 101510012311 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 101510012312 Uncharacterized conserved protein [Function unknown]; Region: COG1262 101510012313 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 101510012314 Domain of unknown function (DUF202); Region: DUF202; pfam02656 101510012315 putative amidase; Provisional; Region: PRK06169 101510012316 Amidase; Region: Amidase; pfam01425 101510012317 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 101510012318 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 101510012319 NAD binding site [chemical binding]; other site 101510012320 ligand binding site [chemical binding]; other site 101510012321 catalytic site [active] 101510012322 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 101510012323 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 101510012324 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510012325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510012326 DNA-binding site [nucleotide binding]; DNA binding site 101510012327 FCD domain; Region: FCD; pfam07729 101510012328 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 101510012329 MarR family; Region: MarR_2; cl17246 101510012330 MarR family; Region: MarR_2; cl17246 101510012331 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 101510012332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510012333 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 101510012334 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 101510012335 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 101510012336 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 101510012337 short chain dehydrogenase; Provisional; Region: PRK05875 101510012338 classical (c) SDRs; Region: SDR_c; cd05233 101510012339 NAD(P) binding site [chemical binding]; other site 101510012340 active site 101510012341 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510012342 Cytochrome P450; Region: p450; cl12078 101510012343 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510012344 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510012345 active site 101510012346 catalytic tetrad [active] 101510012347 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 101510012348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510012349 active site 101510012350 motif I; other site 101510012351 motif II; other site 101510012352 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 101510012353 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 101510012354 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510012355 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510012356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012357 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012358 active site 101510012359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012360 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012361 active site 101510012362 enoyl-CoA hydratase; Provisional; Region: PRK08290 101510012363 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510012364 substrate binding site [chemical binding]; other site 101510012365 oxyanion hole (OAH) forming residues; other site 101510012366 trimer interface [polypeptide binding]; other site 101510012367 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 101510012368 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510012369 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 101510012370 acyl-activating enzyme (AAE) consensus motif; other site 101510012371 putative AMP binding site [chemical binding]; other site 101510012372 putative active site [active] 101510012373 putative CoA binding site [chemical binding]; other site 101510012374 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 101510012375 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 101510012376 FAD binding site [chemical binding]; other site 101510012377 substrate binding site [chemical binding]; other site 101510012378 catalytic base [active] 101510012379 short chain dehydrogenase; Provisional; Region: PRK07831 101510012380 classical (c) SDRs; Region: SDR_c; cd05233 101510012381 NAD(P) binding site [chemical binding]; other site 101510012382 active site 101510012383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510012384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012385 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 101510012386 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510012387 dimer interface [polypeptide binding]; other site 101510012388 active site 101510012389 putative acetyltransferase; Provisional; Region: PRK03624 101510012390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510012391 Coenzyme A binding pocket [chemical binding]; other site 101510012392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510012393 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 101510012394 Walker A motif; other site 101510012395 ATP binding site [chemical binding]; other site 101510012396 Walker B motif; other site 101510012397 arginine finger; other site 101510012398 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 101510012399 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 101510012400 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510012401 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 101510012402 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 101510012403 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 101510012404 NifU-like domain; Region: NifU; cl00484 101510012405 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510012406 [2Fe-2S] cluster binding site [ion binding]; other site 101510012407 iron-sulfur cluster [ion binding]; other site 101510012408 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 101510012409 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 101510012410 nickel binding site [ion binding]; other site 101510012411 HupF/HypC family; Region: HupF_HypC; pfam01455 101510012412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012413 NADH(P)-binding; Region: NAD_binding_10; pfam13460 101510012414 NAD(P) binding site [chemical binding]; other site 101510012415 active site 101510012416 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 101510012417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012418 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 101510012419 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 101510012420 Hemerythrin-like domain; Region: Hr-like; cd12108 101510012421 Fe binding site [ion binding]; other site 101510012422 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 101510012423 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 101510012424 HupF/HypC family; Region: HupF_HypC; pfam01455 101510012425 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 101510012426 dimerization interface [polypeptide binding]; other site 101510012427 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 101510012428 ATP binding site [chemical binding]; other site 101510012429 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 101510012430 dimer interface [polypeptide binding]; other site 101510012431 active site 101510012432 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 101510012433 HupF/HypC family; Region: HupF_HypC; cl00394 101510012434 Acylphosphatase; Region: Acylphosphatase; pfam00708 101510012435 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 101510012436 HypF finger; Region: zf-HYPF; pfam07503 101510012437 HypF finger; Region: zf-HYPF; pfam07503 101510012438 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 101510012439 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 101510012440 Clp protease; Region: CLP_protease; pfam00574 101510012441 oligomer interface [polypeptide binding]; other site 101510012442 active site residues [active] 101510012443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510012444 salt bridge; other site 101510012445 non-specific DNA binding site [nucleotide binding]; other site 101510012446 sequence-specific DNA binding site [nucleotide binding]; other site 101510012447 hydroxyglutarate oxidase; Provisional; Region: PRK11728 101510012448 Predicted dehydrogenase [General function prediction only]; Region: COG0579 101510012449 Cytochrome P450; Region: p450; pfam00067 101510012450 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510012451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510012452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012453 aldolase II superfamily protein; Provisional; Region: PRK07044 101510012454 intersubunit interface [polypeptide binding]; other site 101510012455 active site 101510012456 Zn2+ binding site [ion binding]; other site 101510012457 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 101510012458 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 101510012459 ligand binding site [chemical binding]; other site 101510012460 NAD binding site [chemical binding]; other site 101510012461 catalytic site [active] 101510012462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012463 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510012464 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 101510012465 Na binding site [ion binding]; other site 101510012466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510012467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510012468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 101510012469 dimerization interface [polypeptide binding]; other site 101510012470 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510012471 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510012472 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510012473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012475 active site 101510012476 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 101510012477 DNA-binding site [nucleotide binding]; DNA binding site 101510012478 RNA-binding motif; other site 101510012479 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510012480 agmatinase; Region: agmatinase; TIGR01230 101510012481 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 101510012482 putative active site [active] 101510012483 putative metal binding site [ion binding]; other site 101510012484 imidazolonepropionase; Provisional; Region: PRK14085 101510012485 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 101510012486 active site 101510012487 urocanate hydratase; Provisional; Region: PRK05414 101510012488 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510012489 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 101510012490 Na binding site [ion binding]; other site 101510012491 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 101510012492 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 101510012493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510012494 DNA-binding site [nucleotide binding]; DNA binding site 101510012495 UTRA domain; Region: UTRA; pfam07702 101510012496 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510012497 Transcriptional regulator PadR-like family; Region: PadR; cl17335 101510012498 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 101510012499 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 101510012500 Nitronate monooxygenase; Region: NMO; pfam03060 101510012501 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510012502 FMN binding site [chemical binding]; other site 101510012503 substrate binding site [chemical binding]; other site 101510012504 putative catalytic residue [active] 101510012505 Coenzyme A transferase; Region: CoA_trans; cl17247 101510012506 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 101510012507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510012508 substrate binding site [chemical binding]; other site 101510012509 oxyanion hole (OAH) forming residues; other site 101510012510 trimer interface [polypeptide binding]; other site 101510012511 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 101510012512 short chain dehydrogenase; Provisional; Region: PRK07856 101510012513 classical (c) SDRs; Region: SDR_c; cd05233 101510012514 NAD(P) binding site [chemical binding]; other site 101510012515 active site 101510012516 short chain dehydrogenase; Provisional; Region: PRK07791 101510012517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012518 NAD(P) binding site [chemical binding]; other site 101510012519 active site 101510012520 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510012521 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510012522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510012523 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510012524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510012525 S-adenosylmethionine binding site [chemical binding]; other site 101510012526 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 101510012527 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 101510012528 Methyltransferase domain; Region: Methyltransf_24; pfam13578 101510012529 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 101510012530 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 101510012531 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510012532 short chain dehydrogenase; Provisional; Region: PRK07774 101510012533 classical (c) SDRs; Region: SDR_c; cd05233 101510012534 NAD(P) binding site [chemical binding]; other site 101510012535 active site 101510012536 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 101510012537 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 101510012538 NAD binding site [chemical binding]; other site 101510012539 catalytic residues [active] 101510012540 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510012541 classical (c) SDRs; Region: SDR_c; cd05233 101510012542 NAD(P) binding site [chemical binding]; other site 101510012543 active site 101510012544 PAS domain; Region: PAS; smart00091 101510012545 PAS fold; Region: PAS; pfam00989 101510012546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510012547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012548 WHG domain; Region: WHG; pfam13305 101510012549 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510012550 Cytochrome P450; Region: p450; cl12078 101510012551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510012552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012553 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510012554 Cytochrome P450; Region: p450; cl12078 101510012555 short chain dehydrogenase; Provisional; Region: PRK07775 101510012556 classical (c) SDRs; Region: SDR_c; cd05233 101510012557 NAD(P) binding site [chemical binding]; other site 101510012558 active site 101510012559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510012560 Cytochrome P450; Region: p450; cl12078 101510012561 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 101510012562 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 101510012563 acyl-CoA synthetase; Validated; Region: PRK07798 101510012564 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510012565 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 101510012566 acyl-activating enzyme (AAE) consensus motif; other site 101510012567 acyl-activating enzyme (AAE) consensus motif; other site 101510012568 putative AMP binding site [chemical binding]; other site 101510012569 putative active site [active] 101510012570 putative CoA binding site [chemical binding]; other site 101510012571 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 101510012572 primary dimer interface [polypeptide binding]; other site 101510012573 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 101510012574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510012575 Coenzyme A binding pocket [chemical binding]; other site 101510012576 Domain of unknown function (DUF385); Region: DUF385; pfam04075 101510012577 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 101510012578 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510012579 dimer interface [polypeptide binding]; other site 101510012580 active site 101510012581 Cytochrome P450; Region: p450; cl12078 101510012582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510012583 Erythromycin esterase; Region: Erythro_esteras; pfam05139 101510012584 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510012585 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510012586 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510012587 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 101510012588 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510012589 active site 101510012590 lipid-transfer protein; Provisional; Region: PRK07937 101510012591 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510012592 active site 101510012593 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 101510012594 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510012595 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 101510012596 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510012597 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510012598 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 101510012599 enoyl-CoA hydratase; Provisional; Region: PRK07799 101510012600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510012601 substrate binding site [chemical binding]; other site 101510012602 oxyanion hole (OAH) forming residues; other site 101510012603 trimer interface [polypeptide binding]; other site 101510012604 acyl-CoA synthetase; Validated; Region: PRK07798 101510012605 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510012606 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 101510012607 acyl-activating enzyme (AAE) consensus motif; other site 101510012608 acyl-activating enzyme (AAE) consensus motif; other site 101510012609 putative AMP binding site [chemical binding]; other site 101510012610 putative active site [active] 101510012611 putative CoA binding site [chemical binding]; other site 101510012612 Nitronate monooxygenase; Region: NMO; pfam03060 101510012613 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510012614 FMN binding site [chemical binding]; other site 101510012615 substrate binding site [chemical binding]; other site 101510012616 putative catalytic residue [active] 101510012617 acyl-CoA synthetase; Validated; Region: PRK07867 101510012618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510012619 acyl-activating enzyme (AAE) consensus motif; other site 101510012620 AMP binding site [chemical binding]; other site 101510012621 active site 101510012622 CoA binding site [chemical binding]; other site 101510012623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012624 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510012625 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510012626 active site 101510012627 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012628 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 101510012629 FAD binding site [chemical binding]; other site 101510012630 substrate binding site [chemical binding]; other site 101510012631 catalytic base [active] 101510012632 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 101510012633 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 101510012634 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 101510012635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012636 NAD(P) binding site [chemical binding]; other site 101510012637 active site 101510012638 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 101510012639 Permease; Region: Permease; pfam02405 101510012640 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 101510012641 Permease; Region: Permease; pfam02405 101510012642 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 101510012643 mce related protein; Region: MCE; pfam02470 101510012644 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510012645 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510012646 mce related protein; Region: MCE; pfam02470 101510012647 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510012648 mce related protein; Region: MCE; pfam02470 101510012649 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510012650 mce related protein; Region: MCE; pfam02470 101510012651 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 101510012652 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510012653 mce related protein; Region: MCE; pfam02470 101510012654 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510012655 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510012656 mce related protein; Region: MCE; pfam02470 101510012657 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510012658 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 101510012659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012660 NAD(P) binding site [chemical binding]; other site 101510012661 active site 101510012662 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 101510012663 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 101510012664 active site 101510012665 homotetramer interface [polypeptide binding]; other site 101510012666 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 101510012667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510012668 ABC transporter signature motif; other site 101510012669 Walker B; other site 101510012670 D-loop; other site 101510012671 H-loop/switch region; other site 101510012672 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510012673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510012674 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 101510012675 Walker A/P-loop; other site 101510012676 ATP binding site [chemical binding]; other site 101510012677 Q-loop/lid; other site 101510012678 ABC transporter signature motif; other site 101510012679 Walker B; other site 101510012680 D-loop; other site 101510012681 H-loop/switch region; other site 101510012682 putative formyltransferase; Provisional; Region: PRK06988 101510012683 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 101510012684 active site 101510012685 substrate binding site [chemical binding]; other site 101510012686 cosubstrate binding site; other site 101510012687 catalytic site [active] 101510012688 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 101510012689 active site 101510012690 hexamer interface [polypeptide binding]; other site 101510012691 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510012692 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510012693 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510012694 PAS fold; Region: PAS_3; pfam08447 101510012695 PAS fold; Region: PAS_4; pfam08448 101510012696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 101510012697 putative active site [active] 101510012698 heme pocket [chemical binding]; other site 101510012699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 101510012700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510012701 metal binding site [ion binding]; metal-binding site 101510012702 active site 101510012703 I-site; other site 101510012704 Condensation domain; Region: Condensation; pfam00668 101510012705 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510012706 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510012707 acyl-activating enzyme (AAE) consensus motif; other site 101510012708 AMP binding site [chemical binding]; other site 101510012709 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510012710 Condensation domain; Region: Condensation; pfam00668 101510012711 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510012712 Condensation domain; Region: Condensation; pfam00668 101510012713 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510012714 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510012715 acyl-activating enzyme (AAE) consensus motif; other site 101510012716 AMP binding site [chemical binding]; other site 101510012717 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510012718 Condensation domain; Region: Condensation; pfam00668 101510012719 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510012720 Condensation domain; Region: Condensation; pfam00668 101510012721 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510012722 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510012723 acyl-activating enzyme (AAE) consensus motif; other site 101510012724 AMP binding site [chemical binding]; other site 101510012725 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510012726 Condensation domain; Region: Condensation; pfam00668 101510012727 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510012728 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510012729 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510012730 acyl-activating enzyme (AAE) consensus motif; other site 101510012731 AMP binding site [chemical binding]; other site 101510012732 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510012733 Condensation domain; Region: Condensation; pfam00668 101510012734 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510012735 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510012736 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 101510012737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510012738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510012739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 101510012740 Uncharacterized conserved protein [Function unknown]; Region: COG2966 101510012741 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 101510012742 Uncharacterized conserved protein [Function unknown]; Region: COG3610 101510012743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 101510012744 DNA binding residues [nucleotide binding] 101510012745 Secretory lipase; Region: LIP; pfam03583 101510012746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510012747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012748 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 101510012749 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 101510012750 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 101510012751 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 101510012752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510012753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012754 NADH(P)-binding; Region: NAD_binding_10; pfam13460 101510012755 NAD(P) binding site [chemical binding]; other site 101510012756 active site 101510012757 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 101510012758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510012759 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 101510012760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510012761 DNA binding residues [nucleotide binding] 101510012762 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510012763 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510012764 DNA binding residues [nucleotide binding] 101510012765 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 101510012766 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510012767 DNA binding residues [nucleotide binding] 101510012768 putative dimer interface [polypeptide binding]; other site 101510012769 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 101510012770 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 101510012771 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 101510012772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510012773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510012774 active site 101510012775 phosphorylation site [posttranslational modification] 101510012776 intermolecular recognition site; other site 101510012777 dimerization interface [polypeptide binding]; other site 101510012778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510012779 DNA binding site [nucleotide binding] 101510012780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510012781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510012782 dimerization interface [polypeptide binding]; other site 101510012783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510012784 dimer interface [polypeptide binding]; other site 101510012785 phosphorylation site [posttranslational modification] 101510012786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510012787 ATP binding site [chemical binding]; other site 101510012788 Mg2+ binding site [ion binding]; other site 101510012789 G-X-G motif; other site 101510012790 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 101510012791 nucleotide binding site/active site [active] 101510012792 HIT family signature motif; other site 101510012793 catalytic residue [active] 101510012794 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 101510012795 Ligand binding site; other site 101510012796 Ligand binding site; other site 101510012797 Ligand binding site; other site 101510012798 Putative Catalytic site; other site 101510012799 DXD motif; other site 101510012800 Predicted membrane protein [Function unknown]; Region: COG2246 101510012801 GtrA-like protein; Region: GtrA; pfam04138 101510012802 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 101510012803 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 101510012804 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012805 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510012806 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012807 active site 101510012808 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510012809 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510012810 substrate binding site [chemical binding]; other site 101510012811 oxyanion hole (OAH) forming residues; other site 101510012812 trimer interface [polypeptide binding]; other site 101510012813 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 101510012814 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510012815 lipid-transfer protein; Provisional; Region: PRK08256 101510012816 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510012817 active site 101510012818 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012819 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012820 active site 101510012821 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510012822 Phosphotransferase enzyme family; Region: APH; pfam01636 101510012823 putative active site [active] 101510012824 putative substrate binding site [chemical binding]; other site 101510012825 ATP binding site [chemical binding]; other site 101510012826 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510012827 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510012828 active site 101510012829 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510012830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012831 NAD(P) binding site [chemical binding]; other site 101510012832 active site 101510012833 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510012834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012835 NAD(P) binding site [chemical binding]; other site 101510012836 active site 101510012837 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510012838 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 101510012839 NAD binding site [chemical binding]; other site 101510012840 substrate binding site [chemical binding]; other site 101510012841 catalytic Zn binding site [ion binding]; other site 101510012842 structural Zn binding site [ion binding]; other site 101510012843 AMP-binding enzyme; Region: AMP-binding; pfam00501 101510012844 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510012845 acyl-activating enzyme (AAE) consensus motif; other site 101510012846 AMP binding site [chemical binding]; other site 101510012847 active site 101510012848 CoA binding site [chemical binding]; other site 101510012849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510012850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510012851 EthD domain; Region: EthD; cl17553 101510012852 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510012853 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 101510012854 Prostaglandin dehydrogenases; Region: PGDH; cd05288 101510012855 NAD(P) binding site [chemical binding]; other site 101510012856 substrate binding site [chemical binding]; other site 101510012857 dimer interface [polypeptide binding]; other site 101510012858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012859 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510012860 NAD(P) binding site [chemical binding]; other site 101510012861 active site 101510012862 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 101510012863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510012864 dimer interface [polypeptide binding]; other site 101510012865 conserved gate region; other site 101510012866 ABC-ATPase subunit interface; other site 101510012867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510012868 dimer interface [polypeptide binding]; other site 101510012869 conserved gate region; other site 101510012870 putative PBP binding loops; other site 101510012871 ABC-ATPase subunit interface; other site 101510012872 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 101510012873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510012874 Walker A/P-loop; other site 101510012875 ATP binding site [chemical binding]; other site 101510012876 Q-loop/lid; other site 101510012877 ABC transporter signature motif; other site 101510012878 Walker B; other site 101510012879 D-loop; other site 101510012880 H-loop/switch region; other site 101510012881 TOBE domain; Region: TOBE_2; pfam08402 101510012882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012883 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510012884 NAD(P) binding site [chemical binding]; other site 101510012885 active site 101510012886 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 101510012887 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 101510012888 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510012889 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 101510012890 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510012891 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 101510012892 phosphate binding site [ion binding]; other site 101510012893 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 101510012894 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 101510012895 TM-ABC transporter signature motif; other site 101510012896 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 101510012897 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 101510012898 TM-ABC transporter signature motif; other site 101510012899 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510012900 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 101510012901 Walker A/P-loop; other site 101510012902 ATP binding site [chemical binding]; other site 101510012903 Q-loop/lid; other site 101510012904 ABC transporter signature motif; other site 101510012905 Walker B; other site 101510012906 D-loop; other site 101510012907 H-loop/switch region; other site 101510012908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510012909 Walker A/P-loop; other site 101510012910 ATP binding site [chemical binding]; other site 101510012911 Q-loop/lid; other site 101510012912 ABC transporter signature motif; other site 101510012913 Walker B; other site 101510012914 D-loop; other site 101510012915 H-loop/switch region; other site 101510012916 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 101510012917 classical (c) SDRs; Region: SDR_c; cd05233 101510012918 NAD(P) binding site [chemical binding]; other site 101510012919 active site 101510012920 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 101510012921 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 101510012922 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 101510012923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510012924 dimerization interface [polypeptide binding]; other site 101510012925 putative DNA binding site [nucleotide binding]; other site 101510012926 putative Zn2+ binding site [ion binding]; other site 101510012927 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 101510012928 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 101510012929 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 101510012930 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 101510012931 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 101510012932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012933 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 101510012934 NAD(P) binding site [chemical binding]; other site 101510012935 active site 101510012936 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510012937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510012938 putative substrate translocation pore; other site 101510012939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510012940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510012941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510012942 dimerization interface [polypeptide binding]; other site 101510012943 aspartate aminotransferase; Provisional; Region: PRK05764 101510012944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510012945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510012946 homodimer interface [polypeptide binding]; other site 101510012947 catalytic residue [active] 101510012948 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 101510012949 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 101510012950 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 101510012951 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 101510012952 Protein of unknown function (DUF998); Region: DUF998; pfam06197 101510012953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 101510012954 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 101510012955 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 101510012956 tetramer interface [polypeptide binding]; other site 101510012957 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 101510012958 HIT family signature motif; other site 101510012959 catalytic residue [active] 101510012960 NRDE protein; Region: NRDE; cl01315 101510012961 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510012962 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 101510012963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510012964 Walker A/P-loop; other site 101510012965 ATP binding site [chemical binding]; other site 101510012966 Q-loop/lid; other site 101510012967 ABC transporter signature motif; other site 101510012968 Walker B; other site 101510012969 D-loop; other site 101510012970 H-loop/switch region; other site 101510012971 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510012972 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510012973 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 101510012974 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 101510012975 acyl-activating enzyme (AAE) consensus motif; other site 101510012976 active site 101510012977 AMP binding site [chemical binding]; other site 101510012978 substrate binding site [chemical binding]; other site 101510012979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510012980 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 101510012981 NAD(P) binding site [chemical binding]; other site 101510012982 active site 101510012983 isochorismate synthase DhbC; Validated; Region: PRK06923 101510012984 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 101510012985 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 101510012986 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 101510012987 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 101510012988 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 101510012989 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510012990 Na binding site [ion binding]; other site 101510012991 amidase; Provisional; Region: PRK07486 101510012992 Amidase; Region: Amidase; cl11426 101510012993 pyruvate kinase; Provisional; Region: PRK06247 101510012994 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 101510012995 active site 101510012996 domain interfaces; other site 101510012997 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 101510012998 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 101510012999 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 101510013000 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 101510013001 tartrate dehydrogenase; Region: TTC; TIGR02089 101510013002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510013003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510013004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 101510013005 dimerization interface [polypeptide binding]; other site 101510013006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510013008 putative substrate translocation pore; other site 101510013009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013010 amphi-Trp domain; Region: amphi-Trp; TIGR04354 101510013011 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 101510013012 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 101510013013 putative active site [active] 101510013014 putative dimer interface [polypeptide binding]; other site 101510013015 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 101510013016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 101510013017 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 101510013018 Cupin domain; Region: Cupin_2; pfam07883 101510013019 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 101510013020 glycerate dehydrogenase; Provisional; Region: PRK06932 101510013021 NAD binding site [chemical binding]; other site 101510013022 ligand binding site [chemical binding]; other site 101510013023 catalytic site [active] 101510013024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013025 putative substrate translocation pore; other site 101510013026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013027 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 101510013028 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 101510013029 conserved cys residue [active] 101510013030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510013031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510013032 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 101510013033 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 101510013034 conserved cys residue [active] 101510013035 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 101510013036 ATP binding site [chemical binding]; other site 101510013037 active site 101510013038 substrate binding site [chemical binding]; other site 101510013039 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 101510013040 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510013041 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 101510013042 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 101510013043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510013044 active site 101510013045 phosphorylation site [posttranslational modification] 101510013046 intermolecular recognition site; other site 101510013047 dimerization interface [polypeptide binding]; other site 101510013048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 101510013049 putative Zn2+ binding site [ion binding]; other site 101510013050 putative DNA binding site [nucleotide binding]; other site 101510013051 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 101510013052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510013053 ATP binding site [chemical binding]; other site 101510013054 Mg2+ binding site [ion binding]; other site 101510013055 G-X-G motif; other site 101510013056 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 101510013057 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 101510013058 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 101510013059 catalytic residues [active] 101510013060 dimer interface [polypeptide binding]; other site 101510013061 Predicted deacetylase [General function prediction only]; Region: COG3233 101510013062 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 101510013063 putative active site [active] 101510013064 putative Zn binding site [ion binding]; other site 101510013065 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 101510013066 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 101510013067 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 101510013068 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 101510013069 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 101510013070 putative active site [active] 101510013071 catalytic triad [active] 101510013072 Transcription factor WhiB; Region: Whib; pfam02467 101510013073 putative methyltransferase; Provisional; Region: PRK14967 101510013074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 101510013075 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 101510013076 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 101510013077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013079 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 101510013080 glycosyltransferase, MGT family; Region: MGT; TIGR01426 101510013081 active site 101510013082 TDP-binding site; other site 101510013083 acceptor substrate-binding pocket; other site 101510013084 homodimer interface [polypeptide binding]; other site 101510013085 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510013086 active site 101510013087 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 101510013088 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 101510013089 active site 101510013090 metal binding site [ion binding]; metal-binding site 101510013091 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 101510013092 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 101510013093 dimerization interface [polypeptide binding]; other site 101510013094 ATP binding site [chemical binding]; other site 101510013095 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 101510013096 dimerization interface [polypeptide binding]; other site 101510013097 ATP binding site [chemical binding]; other site 101510013098 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 101510013099 CAAX protease self-immunity; Region: Abi; pfam02517 101510013100 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 101510013101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 101510013102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510013103 S-adenosylmethionine binding site [chemical binding]; other site 101510013104 amidophosphoribosyltransferase; Provisional; Region: PRK07847 101510013105 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 101510013106 active site 101510013107 tetramer interface [polypeptide binding]; other site 101510013108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510013109 active site 101510013110 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 101510013111 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 101510013112 dimerization interface [polypeptide binding]; other site 101510013113 putative ATP binding site [chemical binding]; other site 101510013114 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 101510013115 L-asparaginase II; Region: Asparaginase_II; pfam06089 101510013116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 101510013117 MOSC domain; Region: MOSC; pfam03473 101510013118 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 101510013119 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 101510013120 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 101510013121 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 101510013122 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 101510013123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510013124 catalytic residue [active] 101510013125 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 101510013126 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 101510013127 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 101510013128 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 101510013129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013130 Walker A/P-loop; other site 101510013131 ATP binding site [chemical binding]; other site 101510013132 Q-loop/lid; other site 101510013133 ABC transporter signature motif; other site 101510013134 Walker B; other site 101510013135 D-loop; other site 101510013136 H-loop/switch region; other site 101510013137 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 101510013138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013139 Walker A/P-loop; other site 101510013140 ATP binding site [chemical binding]; other site 101510013141 Q-loop/lid; other site 101510013142 ABC transporter signature motif; other site 101510013143 Walker B; other site 101510013144 D-loop; other site 101510013145 H-loop/switch region; other site 101510013146 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 101510013147 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 101510013148 heme-binding site [chemical binding]; other site 101510013149 Cutinase; Region: Cutinase; pfam01083 101510013150 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 101510013151 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 101510013152 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 101510013153 active site residue [active] 101510013154 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 101510013155 active site residue [active] 101510013156 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 101510013157 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 101510013158 catalytic residues [active] 101510013159 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 101510013160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510013161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510013162 DNA binding site [nucleotide binding] 101510013163 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 101510013164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510013165 Coenzyme A binding pocket [chemical binding]; other site 101510013166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 101510013167 PBP superfamily domain; Region: PBP_like_2; cl17296 101510013168 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 101510013169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510013170 dimer interface [polypeptide binding]; other site 101510013171 conserved gate region; other site 101510013172 putative PBP binding loops; other site 101510013173 ABC-ATPase subunit interface; other site 101510013174 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 101510013175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510013176 dimer interface [polypeptide binding]; other site 101510013177 conserved gate region; other site 101510013178 putative PBP binding loops; other site 101510013179 ABC-ATPase subunit interface; other site 101510013180 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 101510013181 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 101510013182 Walker A/P-loop; other site 101510013183 ATP binding site [chemical binding]; other site 101510013184 Q-loop/lid; other site 101510013185 ABC transporter signature motif; other site 101510013186 Walker B; other site 101510013187 D-loop; other site 101510013188 H-loop/switch region; other site 101510013189 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 101510013190 PhoU domain; Region: PhoU; pfam01895 101510013191 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 101510013192 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 101510013193 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 101510013194 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 101510013195 FMN binding site [chemical binding]; other site 101510013196 active site 101510013197 catalytic residues [active] 101510013198 substrate binding site [chemical binding]; other site 101510013199 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 101510013200 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 101510013201 homodimer interface [polypeptide binding]; other site 101510013202 putative substrate binding pocket [chemical binding]; other site 101510013203 diiron center [ion binding]; other site 101510013204 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 101510013205 Protein of unknown function (DUF419); Region: DUF419; pfam04237 101510013206 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 101510013207 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 101510013208 catalytic Zn binding site [ion binding]; other site 101510013209 NAD binding site [chemical binding]; other site 101510013210 structural Zn binding site [ion binding]; other site 101510013211 GXWXG protein; Region: GXWXG; pfam14231 101510013212 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 101510013213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013219 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510013220 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510013221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013223 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 101510013224 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 101510013225 Walker A/P-loop; other site 101510013226 ATP binding site [chemical binding]; other site 101510013227 Q-loop/lid; other site 101510013228 ABC transporter signature motif; other site 101510013229 Walker B; other site 101510013230 D-loop; other site 101510013231 H-loop/switch region; other site 101510013232 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 101510013233 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 101510013234 TM-ABC transporter signature motif; other site 101510013235 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 101510013236 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 101510013237 Walker A/P-loop; other site 101510013238 ATP binding site [chemical binding]; other site 101510013239 Q-loop/lid; other site 101510013240 ABC transporter signature motif; other site 101510013241 Walker B; other site 101510013242 D-loop; other site 101510013243 H-loop/switch region; other site 101510013244 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 101510013245 TM-ABC transporter signature motif; other site 101510013246 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 101510013247 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 101510013248 ligand binding site [chemical binding]; other site 101510013249 classical (c) SDRs; Region: SDR_c; cd05233 101510013250 NAD(P) binding site [chemical binding]; other site 101510013251 active site 101510013252 Predicted integral membrane protein [Function unknown]; Region: COG0392 101510013253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510013254 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510013255 NAD(P) binding site [chemical binding]; other site 101510013256 active site 101510013257 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 101510013258 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510013259 Ligand Binding Site [chemical binding]; other site 101510013260 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510013261 Ligand Binding Site [chemical binding]; other site 101510013262 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 101510013263 putative active site; other site 101510013264 putative metal binding residues [ion binding]; other site 101510013265 signature motif; other site 101510013266 putative triphosphate binding site [ion binding]; other site 101510013267 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 101510013268 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 101510013269 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 101510013270 probable active site [active] 101510013271 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 101510013272 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510013273 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 101510013274 short chain dehydrogenase; Provisional; Region: PRK06197 101510013275 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 101510013276 putative NAD(P) binding site [chemical binding]; other site 101510013277 active site 101510013278 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 101510013279 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510013280 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 101510013281 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 101510013282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510013283 NAD(P) binding site [chemical binding]; other site 101510013284 active site 101510013285 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510013286 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510013287 active site 101510013288 non-prolyl cis peptide bond; other site 101510013289 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 101510013290 Citrate transporter; Region: CitMHS; pfam03600 101510013291 Lsr2; Region: Lsr2; pfam11774 101510013292 NlpC/P60 family; Region: NLPC_P60; cl17555 101510013293 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510013294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510013295 active site 101510013296 metal binding site [ion binding]; metal-binding site 101510013297 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510013298 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510013299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013300 putative substrate translocation pore; other site 101510013301 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 101510013302 hypothetical protein; Provisional; Region: PRK08204 101510013303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510013304 active site 101510013305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510013306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510013307 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 101510013308 substrate binding pocket [chemical binding]; other site 101510013309 dimerization interface [polypeptide binding]; other site 101510013310 hypothetical protein; Provisional; Region: PRK08244 101510013311 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510013312 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510013313 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510013314 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510013315 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510013316 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 101510013317 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510013318 phosphopeptide binding site; other site 101510013319 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510013320 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510013321 phosphopeptide binding site; other site 101510013322 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 101510013323 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 101510013324 Walker A/P-loop; other site 101510013325 ATP binding site [chemical binding]; other site 101510013326 Q-loop/lid; other site 101510013327 ABC transporter signature motif; other site 101510013328 Walker B; other site 101510013329 D-loop; other site 101510013330 H-loop/switch region; other site 101510013331 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 101510013332 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 101510013333 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 101510013334 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510013335 hypothetical protein; Provisional; Region: PRK06184 101510013336 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510013337 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 101510013338 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 101510013339 Clp amino terminal domain; Region: Clp_N; pfam02861 101510013340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510013341 Walker A motif; other site 101510013342 ATP binding site [chemical binding]; other site 101510013343 Walker B motif; other site 101510013344 arginine finger; other site 101510013345 UvrB/uvrC motif; Region: UVR; pfam02151 101510013346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510013347 Walker A motif; other site 101510013348 ATP binding site [chemical binding]; other site 101510013349 Walker B motif; other site 101510013350 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 101510013351 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 101510013352 oligomer interface [polypeptide binding]; other site 101510013353 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510013354 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 101510013355 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510013356 Glycerate kinase family; Region: Gly_kinase; cl00841 101510013357 Glycerate kinase family; Region: Gly_kinase; cl00841 101510013358 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 101510013359 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 101510013360 dimerization interface [polypeptide binding]; other site 101510013361 ligand binding site [chemical binding]; other site 101510013362 NADP binding site [chemical binding]; other site 101510013363 catalytic site [active] 101510013364 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 101510013365 active site 101510013366 catalytic residues [active] 101510013367 metal binding site [ion binding]; metal-binding site 101510013368 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510013369 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510013370 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 101510013371 fructuronate transporter; Provisional; Region: PRK10034; cl15264 101510013372 fructuronate transporter; Provisional; Region: PRK10034; cl15264 101510013373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510013374 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510013375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510013376 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 101510013377 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 101510013378 THF binding site; other site 101510013379 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 101510013380 substrate binding site [chemical binding]; other site 101510013381 THF binding site; other site 101510013382 zinc-binding site [ion binding]; other site 101510013383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013384 ABC transporter signature motif; other site 101510013385 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 101510013386 Walker B; other site 101510013387 D-loop; other site 101510013388 H-loop/switch region; other site 101510013389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013390 Walker A/P-loop; other site 101510013391 ATP binding site [chemical binding]; other site 101510013392 Q-loop/lid; other site 101510013393 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 101510013394 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 101510013395 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 101510013396 MMPL family; Region: MMPL; pfam03176 101510013397 MMPL family; Region: MMPL; pfam03176 101510013398 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 101510013399 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 101510013400 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510013401 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 101510013402 putative NAD(P) binding site [chemical binding]; other site 101510013403 catalytic Zn binding site [ion binding]; other site 101510013404 structural Zn binding site [ion binding]; other site 101510013405 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 101510013406 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 101510013407 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 101510013408 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510013409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510013410 aminotransferase; Validated; Region: PRK07777 101510013411 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510013412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510013413 homodimer interface [polypeptide binding]; other site 101510013414 catalytic residue [active] 101510013415 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510013416 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 101510013417 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 101510013418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510013419 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 101510013420 NMT1/THI5 like; Region: NMT1; pfam09084 101510013421 NMT1-like family; Region: NMT1_2; pfam13379 101510013422 membrane-bound complex binding site; other site 101510013423 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 101510013424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510013425 substrate binding pocket [chemical binding]; other site 101510013426 membrane-bound complex binding site; other site 101510013427 hinge residues; other site 101510013428 EspA-like secreted protein; Region: EspA; cl04069 101510013429 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510013430 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 101510013431 Walker A/P-loop; other site 101510013432 ATP binding site [chemical binding]; other site 101510013433 Q-loop/lid; other site 101510013434 ABC transporter signature motif; other site 101510013435 Walker B; other site 101510013436 D-loop; other site 101510013437 H-loop/switch region; other site 101510013438 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510013439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510013440 dimer interface [polypeptide binding]; other site 101510013441 conserved gate region; other site 101510013442 putative PBP binding loops; other site 101510013443 ABC-ATPase subunit interface; other site 101510013444 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510013445 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510013446 active site 101510013447 non-prolyl cis peptide bond; other site 101510013448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510013450 putative substrate translocation pore; other site 101510013451 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510013452 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 101510013453 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 101510013454 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 101510013455 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 101510013456 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 101510013457 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 101510013458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 101510013459 putative Mg++ binding site [ion binding]; other site 101510013460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510013461 nucleotide binding region [chemical binding]; other site 101510013462 ATP-binding site [chemical binding]; other site 101510013463 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 101510013464 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510013465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 101510013466 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 101510013467 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510013468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510013469 dimer interface [polypeptide binding]; other site 101510013470 conserved gate region; other site 101510013471 putative PBP binding loops; other site 101510013472 ABC-ATPase subunit interface; other site 101510013473 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510013474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013475 Walker A/P-loop; other site 101510013476 ATP binding site [chemical binding]; other site 101510013477 Q-loop/lid; other site 101510013478 ABC transporter signature motif; other site 101510013479 Walker B; other site 101510013480 D-loop; other site 101510013481 H-loop/switch region; other site 101510013482 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510013483 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510013484 active site 101510013485 non-prolyl cis peptide bond; other site 101510013486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 101510013487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510013488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013489 Walker A/P-loop; other site 101510013490 ATP binding site [chemical binding]; other site 101510013491 Q-loop/lid; other site 101510013492 ABC transporter signature motif; other site 101510013493 Walker B; other site 101510013494 D-loop; other site 101510013495 H-loop/switch region; other site 101510013496 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510013497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 101510013499 Walker A/P-loop; other site 101510013500 ATP binding site [chemical binding]; other site 101510013501 Q-loop/lid; other site 101510013502 ABC transporter signature motif; other site 101510013503 Walker B; other site 101510013504 D-loop; other site 101510013505 H-loop/switch region; other site 101510013506 Transposase domain (DUF772); Region: DUF772; pfam05598 101510013507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510013508 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510013509 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 101510013510 Putative esterase; Region: Esterase; pfam00756 101510013511 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 101510013512 WYL domain; Region: WYL; pfam13280 101510013513 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 101510013514 hypothetical protein; Provisional; Region: PRK11770 101510013515 Domain of unknown function (DUF307); Region: DUF307; pfam03733 101510013516 Domain of unknown function (DUF307); Region: DUF307; pfam03733 101510013517 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 101510013518 DNA-binding site [nucleotide binding]; DNA binding site 101510013519 RNA-binding motif; other site 101510013520 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 101510013521 H+ Antiporter protein; Region: 2A0121; TIGR00900 101510013522 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 101510013523 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 101510013524 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 101510013525 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 101510013526 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 101510013527 active site 101510013528 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 101510013529 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 101510013530 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510013531 MarR family; Region: MarR_2; cl17246 101510013532 H+ Antiporter protein; Region: 2A0121; TIGR00900 101510013533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013534 putative substrate translocation pore; other site 101510013535 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 101510013536 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 101510013537 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 101510013538 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 101510013539 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 101510013540 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 101510013541 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510013542 catalytic loop [active] 101510013543 iron binding site [ion binding]; other site 101510013544 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 101510013545 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 101510013546 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 101510013547 metal ion-dependent adhesion site (MIDAS); other site 101510013548 MoxR-like ATPases [General function prediction only]; Region: COG0714 101510013549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510013550 Walker A motif; other site 101510013551 ATP binding site [chemical binding]; other site 101510013552 Walker B motif; other site 101510013553 arginine finger; other site 101510013554 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 101510013555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510013556 NAD(P) binding site [chemical binding]; other site 101510013557 active site 101510013558 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 101510013559 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 101510013560 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 101510013561 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 101510013562 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510013563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510013564 DNA-binding site [nucleotide binding]; DNA binding site 101510013565 FCD domain; Region: FCD; pfam07729 101510013566 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 101510013567 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 101510013568 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 101510013569 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510013570 Walker A/P-loop; other site 101510013571 ATP binding site [chemical binding]; other site 101510013572 Q-loop/lid; other site 101510013573 ABC transporter signature motif; other site 101510013574 Walker B; other site 101510013575 D-loop; other site 101510013576 H-loop/switch region; other site 101510013577 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510013578 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 101510013579 TM-ABC transporter signature motif; other site 101510013580 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510013581 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 101510013582 TM-ABC transporter signature motif; other site 101510013583 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 101510013584 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 101510013585 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 101510013586 nucleoside/Zn binding site; other site 101510013587 dimer interface [polypeptide binding]; other site 101510013588 catalytic motif [active] 101510013589 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510013590 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510013591 catalytic residue [active] 101510013592 citrate synthase 2; Provisional; Region: PRK12350 101510013593 Citrate synthase; Region: Citrate_synt; pfam00285 101510013594 oxalacetate binding site [chemical binding]; other site 101510013595 citrylCoA binding site [chemical binding]; other site 101510013596 coenzyme A binding site [chemical binding]; other site 101510013597 catalytic triad [active] 101510013598 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 101510013599 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 101510013600 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 101510013601 H+ Antiporter protein; Region: 2A0121; TIGR00900 101510013602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013603 putative substrate translocation pore; other site 101510013604 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 101510013605 active site 101510013606 catalytic residues [active] 101510013607 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 101510013608 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 101510013609 dimer interface [polypeptide binding]; other site 101510013610 active site 101510013611 citrylCoA binding site [chemical binding]; other site 101510013612 NADH binding [chemical binding]; other site 101510013613 cationic pore residues; other site 101510013614 oxalacetate/citrate binding site [chemical binding]; other site 101510013615 coenzyme A binding site [chemical binding]; other site 101510013616 catalytic triad [active] 101510013617 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 101510013618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510013619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510013620 phosphorylation site [posttranslational modification] 101510013621 dimer interface [polypeptide binding]; other site 101510013622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510013623 ATP binding site [chemical binding]; other site 101510013624 Mg2+ binding site [ion binding]; other site 101510013625 G-X-G motif; other site 101510013626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510013627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510013628 active site 101510013629 phosphorylation site [posttranslational modification] 101510013630 intermolecular recognition site; other site 101510013631 dimerization interface [polypeptide binding]; other site 101510013632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510013633 DNA binding site [nucleotide binding] 101510013634 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 101510013635 Mechanosensitive ion channel; Region: MS_channel; pfam00924 101510013636 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 101510013637 DNA photolyase; Region: DNA_photolyase; pfam00875 101510013638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013639 putative substrate translocation pore; other site 101510013640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013642 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 101510013643 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 101510013644 acyl-activating enzyme (AAE) consensus motif; other site 101510013645 putative AMP binding site [chemical binding]; other site 101510013646 putative active site [active] 101510013647 putative CoA binding site [chemical binding]; other site 101510013648 Putative esterase; Region: Esterase; pfam00756 101510013649 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 101510013650 Domain of unknown function (DUF222); Region: DUF222; pfam02720 101510013651 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 101510013652 active site 101510013653 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 101510013654 dimer interface [polypeptide binding]; other site 101510013655 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 101510013656 Ligand Binding Site [chemical binding]; other site 101510013657 Molecular Tunnel; other site 101510013658 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 101510013659 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510013660 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510013661 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 101510013662 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 101510013663 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 101510013664 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 101510013665 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 101510013666 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 101510013667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 101510013668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 101510013669 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510013670 hydrophobic ligand binding site; other site 101510013671 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 101510013672 Multicopper oxidase; Region: Cu-oxidase; pfam00394 101510013673 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 101510013674 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 101510013675 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 101510013676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013677 Walker A/P-loop; other site 101510013678 ATP binding site [chemical binding]; other site 101510013679 Q-loop/lid; other site 101510013680 ABC transporter signature motif; other site 101510013681 Walker B; other site 101510013682 D-loop; other site 101510013683 H-loop/switch region; other site 101510013684 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 101510013685 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510013686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510013687 non-specific DNA binding site [nucleotide binding]; other site 101510013688 salt bridge; other site 101510013689 sequence-specific DNA binding site [nucleotide binding]; other site 101510013690 Ferredoxin [Energy production and conversion]; Region: COG1146 101510013691 4Fe-4S binding domain; Region: Fer4; pfam00037 101510013692 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 101510013693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013694 Walker A/P-loop; other site 101510013695 ATP binding site [chemical binding]; other site 101510013696 Q-loop/lid; other site 101510013697 ABC transporter signature motif; other site 101510013698 Walker B; other site 101510013699 D-loop; other site 101510013700 H-loop/switch region; other site 101510013701 ABC transporter; Region: ABC_tran_2; pfam12848 101510013702 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 101510013703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510013704 Methyltransferase domain; Region: Methyltransf_31; pfam13847 101510013705 S-adenosylmethionine binding site [chemical binding]; other site 101510013706 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510013707 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510013708 active site 101510013709 catalytic tetrad [active] 101510013710 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 101510013711 MMPL family; Region: MMPL; pfam03176 101510013712 MMPL family; Region: MMPL; pfam03176 101510013713 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 101510013714 Bacterial transcriptional activator domain; Region: BTAD; smart01043 101510013715 AAA ATPase domain; Region: AAA_16; pfam13191 101510013716 AAA domain; Region: AAA_22; pfam13401 101510013717 Hemerythrin-like domain; Region: Hr-like; cd12108 101510013718 Fe binding site [ion binding]; other site 101510013719 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 101510013720 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 101510013721 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 101510013722 putative active site [active] 101510013723 putative active site [active] 101510013724 catalytic site [active] 101510013725 catalytic site [active] 101510013726 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 101510013727 putative active site [active] 101510013728 catalytic site [active] 101510013729 Secretory lipase; Region: LIP; pfam03583 101510013730 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510013731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510013732 enoyl-CoA hydratase; Provisional; Region: PRK06688 101510013733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510013734 substrate binding site [chemical binding]; other site 101510013735 oxyanion hole (OAH) forming residues; other site 101510013736 trimer interface [polypeptide binding]; other site 101510013737 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 101510013738 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 101510013739 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 101510013740 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510013741 Soluble P-type ATPase [General function prediction only]; Region: COG4087 101510013742 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 101510013743 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 101510013744 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 101510013745 Secretory lipase; Region: LIP; pfam03583 101510013746 Protein of unknown function (DUF419); Region: DUF419; pfam04237 101510013747 Histidine kinase; Region: His_kinase; pfam06580 101510013748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510013749 ATP binding site [chemical binding]; other site 101510013750 Mg2+ binding site [ion binding]; other site 101510013751 G-X-G motif; other site 101510013752 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 101510013753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510013754 active site 101510013755 phosphorylation site [posttranslational modification] 101510013756 intermolecular recognition site; other site 101510013757 dimerization interface [polypeptide binding]; other site 101510013758 LytTr DNA-binding domain; Region: LytTR; smart00850 101510013759 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510013760 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510013761 Na binding site [ion binding]; other site 101510013762 Protein of unknown function, DUF485; Region: DUF485; pfam04341 101510013763 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 101510013764 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 101510013765 Na binding site [ion binding]; other site 101510013766 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510013767 hydrophobic ligand binding site; other site 101510013768 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510013769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510013770 substrate binding pocket [chemical binding]; other site 101510013771 membrane-bound complex binding site; other site 101510013772 hinge residues; other site 101510013773 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 101510013774 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 101510013775 nucleotide binding site [chemical binding]; other site 101510013776 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 101510013777 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 101510013778 active site 101510013779 DNA binding site [nucleotide binding] 101510013780 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 101510013781 DNA binding site [nucleotide binding] 101510013782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510013783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510013784 active site 101510013785 phosphorylation site [posttranslational modification] 101510013786 intermolecular recognition site; other site 101510013787 dimerization interface [polypeptide binding]; other site 101510013788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510013789 DNA binding site [nucleotide binding] 101510013790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510013791 dimerization interface [polypeptide binding]; other site 101510013792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510013793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510013794 dimer interface [polypeptide binding]; other site 101510013795 phosphorylation site [posttranslational modification] 101510013796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510013797 ATP binding site [chemical binding]; other site 101510013798 Mg2+ binding site [ion binding]; other site 101510013799 G-X-G motif; other site 101510013800 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 101510013801 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 101510013802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510013803 Walker A/P-loop; other site 101510013804 ATP binding site [chemical binding]; other site 101510013805 Q-loop/lid; other site 101510013806 ABC transporter signature motif; other site 101510013807 Walker B; other site 101510013808 D-loop; other site 101510013809 H-loop/switch region; other site 101510013810 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510013811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510013812 DNA-binding site [nucleotide binding]; DNA binding site 101510013813 FCD domain; Region: FCD; pfam07729 101510013814 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 101510013815 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510013816 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510013817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510013818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510013819 active site 101510013820 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510013821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510013822 active site 101510013823 short chain dehydrogenase; Provisional; Region: PRK07791 101510013824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510013825 NAD(P) binding site [chemical binding]; other site 101510013826 active site 101510013827 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 101510013828 active site 101510013829 catalytic site [active] 101510013830 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510013831 active site 2 [active] 101510013832 active site 1 [active] 101510013833 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510013834 hydrophobic ligand binding site; other site 101510013835 lipid-transfer protein; Provisional; Region: PRK08256 101510013836 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510013837 active site 101510013838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013840 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510013841 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510013842 active site 101510013843 ATP binding site [chemical binding]; other site 101510013844 substrate binding site [chemical binding]; other site 101510013845 activation loop (A-loop); other site 101510013846 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 101510013847 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 101510013848 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510013849 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510013850 active site 101510013851 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 101510013852 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 101510013853 homodimer interface [polypeptide binding]; other site 101510013854 substrate-cofactor binding pocket; other site 101510013855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510013856 catalytic residue [active] 101510013857 OsmC-like protein; Region: OsmC; pfam02566 101510013858 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 101510013859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510013860 DNA-binding site [nucleotide binding]; DNA binding site 101510013861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510013862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510013863 homodimer interface [polypeptide binding]; other site 101510013864 catalytic residue [active] 101510013865 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 101510013866 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510013867 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 101510013868 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 101510013869 dimer interface [polypeptide binding]; other site 101510013870 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 101510013871 active site 101510013872 Fe binding site [ion binding]; other site 101510013873 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510013874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510013875 dimerization interface [polypeptide binding]; other site 101510013876 putative Zn2+ binding site [ion binding]; other site 101510013877 putative DNA binding site [nucleotide binding]; other site 101510013878 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510013879 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 101510013880 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 101510013881 trimer interface [polypeptide binding]; other site 101510013882 putative metal binding site [ion binding]; other site 101510013883 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510013884 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510013885 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 101510013886 active site 101510013887 catalytic residues [active] 101510013888 metal binding site [ion binding]; metal-binding site 101510013889 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 101510013890 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 101510013891 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 101510013892 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 101510013893 Sulfate transporter family; Region: Sulfate_transp; pfam00916 101510013894 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 101510013895 active site clefts [active] 101510013896 zinc binding site [ion binding]; other site 101510013897 dimer interface [polypeptide binding]; other site 101510013898 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 101510013899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510013900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013904 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 101510013905 cyclase homology domain; Region: CHD; cd07302 101510013906 nucleotidyl binding site; other site 101510013907 metal binding site [ion binding]; metal-binding site 101510013908 dimer interface [polypeptide binding]; other site 101510013909 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 101510013910 6-phosphogluconate dehydratase; Region: edd; TIGR01196 101510013911 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510013912 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510013913 active site 101510013914 catalytic tetrad [active] 101510013915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013916 putative substrate translocation pore; other site 101510013917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510013918 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510013919 FAD binding domain; Region: FAD_binding_4; pfam01565 101510013920 diacylglycerol kinase; Reviewed; Region: PRK11914 101510013921 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 101510013922 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 101510013923 RNA binding surface [nucleotide binding]; other site 101510013924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013925 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510013926 putative substrate translocation pore; other site 101510013927 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 101510013928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510013929 Coenzyme A binding pocket [chemical binding]; other site 101510013930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013931 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510013932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510013933 Methyltransferase domain; Region: Methyltransf_23; pfam13489 101510013934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510013935 S-adenosylmethionine binding site [chemical binding]; other site 101510013936 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 101510013937 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510013938 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510013939 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510013940 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 101510013941 FAD binding site [chemical binding]; other site 101510013942 homotetramer interface [polypeptide binding]; other site 101510013943 substrate binding pocket [chemical binding]; other site 101510013944 catalytic base [active] 101510013945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510013946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510013947 Condensation domain; Region: Condensation; pfam00668 101510013948 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510013949 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510013950 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013951 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510013952 acyl-activating enzyme (AAE) consensus motif; other site 101510013953 AMP binding site [chemical binding]; other site 101510013954 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510013955 Condensation domain; Region: Condensation; pfam00668 101510013956 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510013957 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510013958 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013959 acyl-activating enzyme (AAE) consensus motif; other site 101510013960 AMP binding site [chemical binding]; other site 101510013961 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510013962 peptide synthase; Provisional; Region: PRK12316 101510013963 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510013964 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013965 acyl-activating enzyme (AAE) consensus motif; other site 101510013966 AMP binding site [chemical binding]; other site 101510013967 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510013968 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510013969 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013970 acyl-activating enzyme (AAE) consensus motif; other site 101510013971 AMP binding site [chemical binding]; other site 101510013972 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510013973 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510013974 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013975 acyl-activating enzyme (AAE) consensus motif; other site 101510013976 AMP binding site [chemical binding]; other site 101510013977 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510013978 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510013979 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013980 acyl-activating enzyme (AAE) consensus motif; other site 101510013981 AMP binding site [chemical binding]; other site 101510013982 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510013983 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510013984 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013985 acyl-activating enzyme (AAE) consensus motif; other site 101510013986 AMP binding site [chemical binding]; other site 101510013987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510013988 Condensation domain; Region: Condensation; pfam00668 101510013989 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510013990 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510013991 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013992 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510013993 acyl-activating enzyme (AAE) consensus motif; other site 101510013994 AMP binding site [chemical binding]; other site 101510013995 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510013996 peptide synthase; Provisional; Region: PRK12467 101510013997 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510013998 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510013999 acyl-activating enzyme (AAE) consensus motif; other site 101510014000 AMP binding site [chemical binding]; other site 101510014001 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014002 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014003 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014004 acyl-activating enzyme (AAE) consensus motif; other site 101510014005 AMP binding site [chemical binding]; other site 101510014006 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014007 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510014008 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014009 acyl-activating enzyme (AAE) consensus motif; other site 101510014010 AMP binding site [chemical binding]; other site 101510014011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014012 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510014013 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014014 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014015 acyl-activating enzyme (AAE) consensus motif; other site 101510014016 AMP binding site [chemical binding]; other site 101510014017 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014018 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 101510014019 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 101510014020 active site 101510014021 catalytic site [active] 101510014022 substrate binding site [chemical binding]; other site 101510014023 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 101510014024 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 101510014025 oligomer interface [polypeptide binding]; other site 101510014026 metal binding site [ion binding]; metal-binding site 101510014027 metal binding site [ion binding]; metal-binding site 101510014028 putative Cl binding site [ion binding]; other site 101510014029 basic sphincter; other site 101510014030 hydrophobic gate; other site 101510014031 periplasmic entrance; other site 101510014032 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 101510014033 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 101510014034 active site 101510014035 DNA binding site [nucleotide binding] 101510014036 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 101510014037 DNA binding site [nucleotide binding] 101510014038 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 101510014039 nucleotide binding site [chemical binding]; other site 101510014040 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510014041 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510014042 Dodecin; Region: Dodecin; pfam07311 101510014043 Ferredoxin [Energy production and conversion]; Region: COG1146 101510014044 4Fe-4S binding domain; Region: Fer4; pfam00037 101510014045 ferredoxin-NADP+ reductase; Region: PLN02852 101510014046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 101510014047 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 101510014048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 101510014049 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 101510014050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510014051 dimer interface [polypeptide binding]; other site 101510014052 conserved gate region; other site 101510014053 putative PBP binding loops; other site 101510014054 ABC-ATPase subunit interface; other site 101510014055 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 101510014056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510014057 dimer interface [polypeptide binding]; other site 101510014058 conserved gate region; other site 101510014059 putative PBP binding loops; other site 101510014060 ABC-ATPase subunit interface; other site 101510014061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 101510014062 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 101510014063 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 101510014064 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 101510014065 Walker A/P-loop; other site 101510014066 ATP binding site [chemical binding]; other site 101510014067 Q-loop/lid; other site 101510014068 ABC transporter signature motif; other site 101510014069 Walker B; other site 101510014070 D-loop; other site 101510014071 H-loop/switch region; other site 101510014072 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 101510014073 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 101510014074 active site 101510014075 Zn binding site [ion binding]; other site 101510014076 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 101510014077 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 101510014078 active site 101510014079 Pirin; Region: Pirin; pfam02678 101510014080 Pirin-related protein [General function prediction only]; Region: COG1741 101510014081 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 101510014082 putative active site [active] 101510014083 putative catalytic site [active] 101510014084 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 101510014085 active site 101510014086 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510014087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510014088 NAD(P) binding site [chemical binding]; other site 101510014089 active site 101510014090 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510014091 MarR family; Region: MarR; pfam01047 101510014092 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 101510014093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510014094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510014095 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510014096 dimerization interface [polypeptide binding]; other site 101510014097 substrate binding pocket [chemical binding]; other site 101510014098 shikimate transporter; Provisional; Region: PRK09952 101510014099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510014100 putative substrate translocation pore; other site 101510014101 Predicted acyl esterases [General function prediction only]; Region: COG2936 101510014102 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 101510014103 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510014104 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510014105 acyl-activating enzyme (AAE) consensus motif; other site 101510014106 putative AMP binding site [chemical binding]; other site 101510014107 putative active site [active] 101510014108 putative CoA binding site [chemical binding]; other site 101510014109 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510014110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510014111 putative substrate translocation pore; other site 101510014112 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510014113 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510014114 active site 101510014115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510014116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510014117 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510014118 dimerization interface [polypeptide binding]; other site 101510014119 substrate binding pocket [chemical binding]; other site 101510014120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510014121 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510014122 putative substrate translocation pore; other site 101510014123 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510014124 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510014125 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510014126 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510014127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510014128 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 101510014129 active site 101510014130 Putative esterase; Region: Esterase; pfam00756 101510014131 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510014132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510014133 substrate binding pocket [chemical binding]; other site 101510014134 membrane-bound complex binding site; other site 101510014135 hinge residues; other site 101510014136 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510014137 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510014138 active site 101510014139 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 101510014140 putative dimer interface [polypeptide binding]; other site 101510014141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510014142 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 101510014143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 101510014144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 101510014145 active site 101510014146 catalytic tetrad [active] 101510014147 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 101510014148 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 101510014149 DNA binding residues [nucleotide binding] 101510014150 putative dimer interface [polypeptide binding]; other site 101510014151 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510014152 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 101510014153 Na binding site [ion binding]; other site 101510014154 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 101510014155 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510014156 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 101510014157 nucleoside/Zn binding site; other site 101510014158 dimer interface [polypeptide binding]; other site 101510014159 catalytic motif [active] 101510014160 oxidase reductase; Provisional; Region: PTZ00273 101510014161 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 101510014162 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 101510014163 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 101510014164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510014165 Walker A/P-loop; other site 101510014166 ATP binding site [chemical binding]; other site 101510014167 ABC transporter signature motif; other site 101510014168 Walker B; other site 101510014169 D-loop; other site 101510014170 H-loop/switch region; other site 101510014171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 101510014172 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 101510014173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 101510014174 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 101510014175 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 101510014176 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 101510014177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510014178 putative substrate translocation pore; other site 101510014179 POT family; Region: PTR2; cl17359 101510014180 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 101510014181 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 101510014182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014183 Predicted integral membrane protein [Function unknown]; Region: COG0392 101510014184 YceI-like domain; Region: YceI; smart00867 101510014185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510014186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014187 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510014188 2-isopropylmalate synthase; Validated; Region: PRK03739 101510014189 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 101510014190 active site 101510014191 catalytic residues [active] 101510014192 metal binding site [ion binding]; metal-binding site 101510014193 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 101510014194 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510014195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510014196 DNA-binding site [nucleotide binding]; DNA binding site 101510014197 Predicted integral membrane protein [Function unknown]; Region: COG0392 101510014198 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510014199 dimerization interface [polypeptide binding]; other site 101510014200 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 101510014201 cyclase homology domain; Region: CHD; cd07302 101510014202 nucleotidyl binding site; other site 101510014203 metal binding site [ion binding]; metal-binding site 101510014204 dimer interface [polypeptide binding]; other site 101510014205 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 101510014206 Domain of unknown function DUF20; Region: UPF0118; pfam01594 101510014207 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 101510014208 ATP binding site [chemical binding]; other site 101510014209 Mg2+ binding site [ion binding]; other site 101510014210 G-X-G motif; other site 101510014211 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510014212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510014213 active site 101510014214 phosphorylation site [posttranslational modification] 101510014215 intermolecular recognition site; other site 101510014216 dimerization interface [polypeptide binding]; other site 101510014217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510014218 DNA binding residues [nucleotide binding] 101510014219 dimerization interface [polypeptide binding]; other site 101510014220 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 101510014221 MMPL family; Region: MMPL; pfam03176 101510014222 MMPL family; Region: MMPL; pfam03176 101510014223 LabA_like proteins; Region: LabA_like; cd06167 101510014224 putative metal binding site [ion binding]; other site 101510014225 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 101510014226 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 101510014227 active site 101510014228 substrate-binding site [chemical binding]; other site 101510014229 metal-binding site [ion binding] 101510014230 GTP binding site [chemical binding]; other site 101510014231 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 101510014232 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510014233 NAD binding site [chemical binding]; other site 101510014234 catalytic residues [active] 101510014235 Phosphotransferase enzyme family; Region: APH; pfam01636 101510014236 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510014237 putative active site [active] 101510014238 putative substrate binding site [chemical binding]; other site 101510014239 ATP binding site [chemical binding]; other site 101510014240 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 101510014241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510014242 Methyltransferase domain; Region: Methyltransf_11; pfam08241 101510014243 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510014244 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510014245 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 101510014246 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 101510014247 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 101510014248 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 101510014249 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 101510014250 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510014251 Ligand Binding Site [chemical binding]; other site 101510014252 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 101510014253 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 101510014254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510014255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014256 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510014257 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510014258 active site 2 [active] 101510014259 active site 1 [active] 101510014260 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 101510014261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510014262 NAD(P) binding site [chemical binding]; other site 101510014263 active site 101510014264 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 101510014265 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510014266 dimer interface [polypeptide binding]; other site 101510014267 active site 101510014268 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 101510014269 VanW like protein; Region: VanW; pfam04294 101510014270 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 101510014271 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 101510014272 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 101510014273 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 101510014274 FAD binding site [chemical binding]; other site 101510014275 substrate binding site [chemical binding]; other site 101510014276 catalytic residues [active] 101510014277 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 101510014278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510014279 S-adenosylmethionine binding site [chemical binding]; other site 101510014280 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510014281 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 101510014282 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 101510014283 dimer interface [polypeptide binding]; other site 101510014284 active site 101510014285 CoA binding pocket [chemical binding]; other site 101510014286 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 101510014287 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 101510014288 Uncharacterized conserved protein [Function unknown]; Region: COG3379 101510014289 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 101510014290 Cytochrome P450; Region: p450; cl12078 101510014291 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510014292 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510014293 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510014294 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510014295 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510014296 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 101510014297 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 101510014298 putative active site [active] 101510014299 putative substrate binding site [chemical binding]; other site 101510014300 putative FMN binding site [chemical binding]; other site 101510014301 putative catalytic residues [active] 101510014302 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510014303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510014304 DNA binding residues [nucleotide binding] 101510014305 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 101510014306 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 101510014307 Putative esterase; Region: Esterase; pfam00756 101510014308 hypothetical protein; Provisional; Region: PRK09256 101510014309 Probable transposase; Region: OrfB_IS605; pfam01385 101510014310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510014311 Probable transposase; Region: OrfB_IS605; pfam01385 101510014312 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 101510014313 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 101510014314 active site 101510014315 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 101510014316 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 101510014317 putative hydrophobic ligand binding site [chemical binding]; other site 101510014318 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510014319 dimerization interface [polypeptide binding]; other site 101510014320 putative DNA binding site [nucleotide binding]; other site 101510014321 putative Zn2+ binding site [ion binding]; other site 101510014322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510014323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014324 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 101510014325 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510014326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510014327 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 101510014328 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 101510014329 XdhC Rossmann domain; Region: XdhC_C; pfam13478 101510014330 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 101510014331 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 101510014332 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 101510014333 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510014334 catalytic loop [active] 101510014335 iron binding site [ion binding]; other site 101510014336 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 101510014337 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 101510014338 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 101510014339 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 101510014340 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 101510014341 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 101510014342 XdhC Rossmann domain; Region: XdhC_C; pfam13478 101510014343 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 101510014344 MoxR-like ATPases [General function prediction only]; Region: COG0714 101510014345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510014346 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 101510014347 putative hydrophobic ligand binding site [chemical binding]; other site 101510014348 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 101510014349 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 101510014350 metal ion-dependent adhesion site (MIDAS); other site 101510014351 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 101510014352 nucleotide binding site [chemical binding]; other site 101510014353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 101510014354 PAS domain; Region: PAS_9; pfam13426 101510014355 putative active site [active] 101510014356 heme pocket [chemical binding]; other site 101510014357 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 101510014358 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 101510014359 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 101510014360 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 101510014361 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510014362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510014363 DNA-binding site [nucleotide binding]; DNA binding site 101510014364 FCD domain; Region: FCD; pfam07729 101510014365 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510014366 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510014367 NAD(P) binding site [chemical binding]; other site 101510014368 catalytic residues [active] 101510014369 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 101510014370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510014371 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510014372 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510014373 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510014374 active site 101510014375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510014376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510014377 DNA binding site [nucleotide binding] 101510014378 domain linker motif; other site 101510014379 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 101510014380 ligand binding site [chemical binding]; other site 101510014381 dimerization interface [polypeptide binding]; other site 101510014382 tRNA intron endonuclease, N-terminal domain; Region: tRNA_int_endo_N; pfam02778 101510014383 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510014384 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510014385 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 101510014386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510014387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510014388 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 101510014389 putative dimerization interface [polypeptide binding]; other site 101510014390 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 101510014391 BioY family; Region: BioY; pfam02632 101510014392 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510014393 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510014394 AMP binding site [chemical binding]; other site 101510014395 active site 101510014396 acyl-activating enzyme (AAE) consensus motif; other site 101510014397 acyl-activating enzyme (AAE) consensus motif; other site 101510014398 CoA binding site [chemical binding]; other site 101510014399 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510014400 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 101510014401 dimer interface [polypeptide binding]; other site 101510014402 active site 101510014403 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 101510014404 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 101510014405 Walker A/P-loop; other site 101510014406 ATP binding site [chemical binding]; other site 101510014407 Q-loop/lid; other site 101510014408 ABC transporter signature motif; other site 101510014409 Walker B; other site 101510014410 D-loop; other site 101510014411 H-loop/switch region; other site 101510014412 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 101510014413 acyl-CoA synthetase; Validated; Region: PRK07638 101510014414 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510014415 acyl-activating enzyme (AAE) consensus motif; other site 101510014416 AMP binding site [chemical binding]; other site 101510014417 active site 101510014418 CoA binding site [chemical binding]; other site 101510014419 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 101510014420 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 101510014421 Citrate transporter; Region: CitMHS; pfam03600 101510014422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510014423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510014424 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 101510014425 putative dimerization interface [polypeptide binding]; other site 101510014426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510014427 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510014428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 101510014429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 101510014430 DNA binding site [nucleotide binding] 101510014431 domain linker motif; other site 101510014432 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 101510014433 ligand binding site [chemical binding]; other site 101510014434 dimerization interface [polypeptide binding]; other site 101510014435 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510014436 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510014437 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 101510014438 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510014439 Homeodomain-like domain; Region: HTH_23; pfam13384 101510014440 Winged helix-turn helix; Region: HTH_29; pfam13551 101510014441 Homeodomain-like domain; Region: HTH_32; pfam13565 101510014442 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510014443 Histidine kinase; Region: HisKA_3; pfam07730 101510014444 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 101510014445 ATP binding site [chemical binding]; other site 101510014446 Mg2+ binding site [ion binding]; other site 101510014447 G-X-G motif; other site 101510014448 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510014449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510014450 active site 101510014451 phosphorylation site [posttranslational modification] 101510014452 intermolecular recognition site; other site 101510014453 dimerization interface [polypeptide binding]; other site 101510014454 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510014455 DNA binding residues [nucleotide binding] 101510014456 dimerization interface [polypeptide binding]; other site 101510014457 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 101510014458 metal binding site 2 [ion binding]; metal-binding site 101510014459 putative DNA binding helix; other site 101510014460 metal binding site 1 [ion binding]; metal-binding site 101510014461 dimer interface [polypeptide binding]; other site 101510014462 structural Zn2+ binding site [ion binding]; other site 101510014463 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 101510014464 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 101510014465 dimer interface [polypeptide binding]; other site 101510014466 active site 101510014467 heme binding site [chemical binding]; other site 101510014468 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 101510014469 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 101510014470 acetoin reductases; Region: 23BDH; TIGR02415 101510014471 NAD binding site [chemical binding]; other site 101510014472 homotetramer interface [polypeptide binding]; other site 101510014473 homodimer interface [polypeptide binding]; other site 101510014474 active site 101510014475 substrate binding site [chemical binding]; other site 101510014476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510014477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 101510014478 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510014479 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 101510014480 inhibitor site; inhibition site 101510014481 active site 101510014482 dimer interface [polypeptide binding]; other site 101510014483 catalytic residue [active] 101510014484 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 101510014485 Proline racemase; Region: Pro_racemase; pfam05544 101510014486 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 101510014487 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 101510014488 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510014489 NAD(P) binding site [chemical binding]; other site 101510014490 catalytic residues [active] 101510014491 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 101510014492 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 101510014493 tetrameric interface [polypeptide binding]; other site 101510014494 NAD binding site [chemical binding]; other site 101510014495 catalytic residues [active] 101510014496 substrate binding site [chemical binding]; other site 101510014497 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 101510014498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510014499 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510014500 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510014501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510014502 DNA-binding site [nucleotide binding]; DNA binding site 101510014503 FCD domain; Region: FCD; pfam07729 101510014504 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510014505 classical (c) SDRs; Region: SDR_c; cd05233 101510014506 NAD(P) binding site [chemical binding]; other site 101510014507 active site 101510014508 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 101510014509 amidase; Provisional; Region: PRK07486 101510014510 Amidase; Region: Amidase; cl11426 101510014511 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 101510014512 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510014513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510014514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014515 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510014516 benzoate transport; Region: 2A0115; TIGR00895 101510014517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510014518 putative substrate translocation pore; other site 101510014519 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 101510014520 active site 101510014521 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 101510014522 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 101510014523 homotrimer interaction site [polypeptide binding]; other site 101510014524 putative active site [active] 101510014525 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 101510014526 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 101510014527 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 101510014528 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510014529 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510014530 substrate binding pocket [chemical binding]; other site 101510014531 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510014532 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 101510014533 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 101510014534 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 101510014535 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 101510014536 catalytic triad [active] 101510014537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510014539 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 101510014540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510014542 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510014543 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 101510014544 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 101510014545 acyl-activating enzyme (AAE) consensus motif; other site 101510014546 putative AMP binding site [chemical binding]; other site 101510014547 putative active site [active] 101510014548 putative CoA binding site [chemical binding]; other site 101510014549 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510014550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510014551 substrate binding site [chemical binding]; other site 101510014552 oxyanion hole (OAH) forming residues; other site 101510014553 trimer interface [polypeptide binding]; other site 101510014554 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 101510014555 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 101510014556 NAD binding site [chemical binding]; other site 101510014557 catalytic Zn binding site [ion binding]; other site 101510014558 substrate binding site [chemical binding]; other site 101510014559 structural Zn binding site [ion binding]; other site 101510014560 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510014561 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 101510014562 NAD(P) binding site [chemical binding]; other site 101510014563 catalytic residues [active] 101510014564 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510014565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510014566 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 101510014567 active site 2 [active] 101510014568 active site 1 [active] 101510014569 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 101510014570 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 101510014571 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 101510014572 4-coumarate--CoA ligase; Region: PLN02246 101510014573 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 101510014574 acyl-activating enzyme (AAE) consensus motif; other site 101510014575 active site 101510014576 putative CoA binding site [chemical binding]; other site 101510014577 AMP binding site [chemical binding]; other site 101510014578 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510014579 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510014580 active site 101510014581 ATP binding site [chemical binding]; other site 101510014582 substrate binding site [chemical binding]; other site 101510014583 activation loop (A-loop); other site 101510014584 Predicted ATPase [General function prediction only]; Region: COG3903 101510014585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 101510014586 TPR motif; other site 101510014587 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510014588 binding surface 101510014589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510014590 DNA binding residues [nucleotide binding] 101510014591 dimerization interface [polypeptide binding]; other site 101510014592 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 101510014593 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 101510014594 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510014595 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510014596 Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108 101510014597 NAD(P) binding site [chemical binding]; other site 101510014598 catalytic residues [active] 101510014599 catalytic residues [active] 101510014600 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510014601 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510014602 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 101510014603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510014604 catalytic residue [active] 101510014605 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 101510014606 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 101510014607 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 101510014608 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510014609 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510014610 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510014611 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 101510014612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510014613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014614 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 101510014615 trimer interface [polypeptide binding]; other site 101510014616 active site 101510014617 PGAP1-like protein; Region: PGAP1; pfam07819 101510014618 CHAT domain; Region: CHAT; cl17868 101510014619 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 101510014620 active site 101510014621 catalytic residues [active] 101510014622 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 101510014623 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 101510014624 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 101510014625 active site 101510014626 substrate binding site [chemical binding]; other site 101510014627 Mg2+ binding site [ion binding]; other site 101510014628 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 101510014629 active site 101510014630 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 101510014631 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 101510014632 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 101510014633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510014634 Walker A/P-loop; other site 101510014635 ATP binding site [chemical binding]; other site 101510014636 Q-loop/lid; other site 101510014637 ABC transporter signature motif; other site 101510014638 Walker B; other site 101510014639 D-loop; other site 101510014640 H-loop/switch region; other site 101510014641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510014642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510014643 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 101510014644 Walker A/P-loop; other site 101510014645 ATP binding site [chemical binding]; other site 101510014646 Q-loop/lid; other site 101510014647 ABC transporter signature motif; other site 101510014648 Walker B; other site 101510014649 D-loop; other site 101510014650 H-loop/switch region; other site 101510014651 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510014652 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 101510014653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510014654 dimer interface [polypeptide binding]; other site 101510014655 conserved gate region; other site 101510014656 putative PBP binding loops; other site 101510014657 ABC-ATPase subunit interface; other site 101510014658 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 101510014659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510014660 putative PBP binding loops; other site 101510014661 dimer interface [polypeptide binding]; other site 101510014662 ABC-ATPase subunit interface; other site 101510014663 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510014664 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510014665 Rdx family; Region: Rdx; cl01407 101510014666 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510014667 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510014668 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 101510014669 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 101510014670 catalytic triad [active] 101510014671 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 101510014672 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510014673 DNA binding residues [nucleotide binding] 101510014674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510014675 RNA polymerase factor sigma-70; Validated; Region: PRK08241 101510014676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510014677 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 101510014678 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510014679 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 101510014680 putative hydrophobic ligand binding site [chemical binding]; other site 101510014681 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510014682 dimerization interface [polypeptide binding]; other site 101510014683 putative DNA binding site [nucleotide binding]; other site 101510014684 putative Zn2+ binding site [ion binding]; other site 101510014685 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 101510014686 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 101510014687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510014688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510014689 putative substrate translocation pore; other site 101510014690 MarR family; Region: MarR_2; pfam12802 101510014691 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510014692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510014693 dimerization interface [polypeptide binding]; other site 101510014694 putative DNA binding site [nucleotide binding]; other site 101510014695 putative Zn2+ binding site [ion binding]; other site 101510014696 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 101510014697 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 101510014698 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 101510014699 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 101510014700 active site residue [active] 101510014701 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 101510014702 active site residue [active] 101510014703 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 101510014704 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 101510014705 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 101510014706 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 101510014707 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 101510014708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510014709 motif II; other site 101510014710 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510014711 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 101510014712 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 101510014713 active site 101510014714 TDP-binding site; other site 101510014715 acceptor substrate-binding pocket; other site 101510014716 homodimer interface [polypeptide binding]; other site 101510014717 SPW repeat; Region: SPW; pfam03779 101510014718 SPW repeat; Region: SPW; pfam03779 101510014719 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 101510014720 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 101510014721 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 101510014722 tetrameric interface [polypeptide binding]; other site 101510014723 NAD binding site [chemical binding]; other site 101510014724 catalytic residues [active] 101510014725 substrate binding site [chemical binding]; other site 101510014726 hypothetical protein; Provisional; Region: PRK06541 101510014727 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510014728 inhibitor-cofactor binding pocket; inhibition site 101510014729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510014730 catalytic residue [active] 101510014731 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510014732 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 101510014733 putative DNA binding site [nucleotide binding]; other site 101510014734 putative Zn2+ binding site [ion binding]; other site 101510014735 AsnC family; Region: AsnC_trans_reg; pfam01037 101510014736 Amino acid permease; Region: AA_permease_2; pfam13520 101510014737 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 101510014738 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 101510014739 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 101510014740 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 101510014741 putative substrate binding site [chemical binding]; other site 101510014742 active site 101510014743 Domain of unknown function (DUF385); Region: DUF385; pfam04075 101510014744 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510014745 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510014746 NAD(P) binding site [chemical binding]; other site 101510014747 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510014748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510014749 NAD(P) binding site [chemical binding]; other site 101510014750 active site 101510014751 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510014752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510014753 putative substrate translocation pore; other site 101510014754 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510014755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510014756 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 101510014757 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510014758 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510014759 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 101510014760 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510014761 carboxyltransferase (CT) interaction site; other site 101510014762 biotinylation site [posttranslational modification]; other site 101510014763 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 101510014764 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510014765 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510014766 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510014767 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 101510014768 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510014769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510014770 substrate binding site [chemical binding]; other site 101510014771 oxyanion hole (OAH) forming residues; other site 101510014772 trimer interface [polypeptide binding]; other site 101510014773 enoyl-CoA hydratase; Provisional; Region: PRK06494 101510014774 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510014775 substrate binding site [chemical binding]; other site 101510014776 oxyanion hole (OAH) forming residues; other site 101510014777 trimer interface [polypeptide binding]; other site 101510014778 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510014779 classical (c) SDRs; Region: SDR_c; cd05233 101510014780 NAD(P) binding site [chemical binding]; other site 101510014781 active site 101510014782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510014783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510014784 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510014785 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 101510014786 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 101510014787 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510014788 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 101510014789 acyl-activating enzyme (AAE) consensus motif; other site 101510014790 putative AMP binding site [chemical binding]; other site 101510014791 putative active site [active] 101510014792 putative CoA binding site [chemical binding]; other site 101510014793 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 101510014794 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 101510014795 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 101510014796 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 101510014797 Riboflavin kinase; Region: Flavokinase; smart00904 101510014798 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 101510014799 DNA-binding interface [nucleotide binding]; DNA binding site 101510014800 AAA ATPase domain; Region: AAA_16; pfam13191 101510014801 Predicted ATPase [General function prediction only]; Region: COG3903 101510014802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 101510014803 binding surface 101510014804 TPR motif; other site 101510014805 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510014806 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510014807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510014808 DNA binding residues [nucleotide binding] 101510014809 dimerization interface [polypeptide binding]; other site 101510014810 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510014811 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 101510014812 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510014813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510014814 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510014815 NAD(P) binding site [chemical binding]; other site 101510014816 active site 101510014817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510014818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510014819 putative substrate translocation pore; other site 101510014820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510014821 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 101510014822 Probable transposase; Region: OrfB_IS605; pfam01385 101510014823 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 101510014824 AAA ATPase domain; Region: AAA_16; pfam13191 101510014825 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 101510014826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510014827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510014828 DNA binding residues [nucleotide binding] 101510014829 dimerization interface [polypeptide binding]; other site 101510014830 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 101510014831 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 101510014832 active site 101510014833 catalytic triad [active] 101510014834 propanediol utilization protein PduB; Provisional; Region: PRK15415 101510014835 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 101510014836 Catalytic site; other site 101510014837 Condensation domain; Region: Condensation; pfam00668 101510014838 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014839 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510014840 acyl-activating enzyme (AAE) consensus motif; other site 101510014841 AMP binding site [chemical binding]; other site 101510014842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014843 Condensation domain; Region: Condensation; pfam00668 101510014844 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510014845 Condensation domain; Region: Condensation; pfam00668 101510014846 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014847 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014848 acyl-activating enzyme (AAE) consensus motif; other site 101510014849 AMP binding site [chemical binding]; other site 101510014850 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014851 Condensation domain; Region: Condensation; pfam00668 101510014852 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014853 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014854 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014855 acyl-activating enzyme (AAE) consensus motif; other site 101510014856 AMP binding site [chemical binding]; other site 101510014857 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014858 Condensation domain; Region: Condensation; pfam00668 101510014859 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014860 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014861 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014862 acyl-activating enzyme (AAE) consensus motif; other site 101510014863 AMP binding site [chemical binding]; other site 101510014864 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014865 Condensation domain; Region: Condensation; pfam00668 101510014866 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014867 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014868 Putative esterase; Region: Esterase; pfam00756 101510014869 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 101510014870 Bacterial sugar transferase; Region: Bac_transf; pfam02397 101510014871 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 101510014872 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 101510014873 active site 101510014874 Substrate binding site; other site 101510014875 Mg++ binding site; other site 101510014876 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 101510014877 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 101510014878 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 101510014879 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 101510014880 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 101510014881 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 101510014882 active site 101510014883 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 101510014884 Bacterial sugar transferase; Region: Bac_transf; pfam02397 101510014885 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 101510014886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510014887 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 101510014888 trimer interface [polypeptide binding]; other site 101510014889 active site 101510014890 substrate binding site [chemical binding]; other site 101510014891 CoA binding site [chemical binding]; other site 101510014892 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 101510014893 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510014894 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510014895 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 101510014896 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 101510014897 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 101510014898 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 101510014899 NADP-binding site; other site 101510014900 homotetramer interface [polypeptide binding]; other site 101510014901 substrate binding site [chemical binding]; other site 101510014902 homodimer interface [polypeptide binding]; other site 101510014903 active site 101510014904 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 101510014905 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 101510014906 NADP binding site [chemical binding]; other site 101510014907 active site 101510014908 putative substrate binding site [chemical binding]; other site 101510014909 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 101510014910 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510014911 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 101510014912 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 101510014913 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 101510014914 putative active site [active] 101510014915 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 101510014916 O-Antigen ligase; Region: Wzy_C; pfam04932 101510014917 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 101510014918 Condensation domain; Region: Condensation; pfam00668 101510014919 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014920 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510014921 acyl-activating enzyme (AAE) consensus motif; other site 101510014922 AMP binding site [chemical binding]; other site 101510014923 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014924 Condensation domain; Region: Condensation; pfam00668 101510014925 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014926 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014927 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510014928 acyl-activating enzyme (AAE) consensus motif; other site 101510014929 AMP binding site [chemical binding]; other site 101510014930 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014931 Condensation domain; Region: Condensation; pfam00668 101510014932 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014933 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014934 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014935 acyl-activating enzyme (AAE) consensus motif; other site 101510014936 AMP binding site [chemical binding]; other site 101510014937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014938 Condensation domain; Region: Condensation; pfam00668 101510014939 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014940 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014941 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014942 acyl-activating enzyme (AAE) consensus motif; other site 101510014943 AMP binding site [chemical binding]; other site 101510014944 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014945 Condensation domain; Region: Condensation; pfam00668 101510014946 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014947 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014948 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014949 acyl-activating enzyme (AAE) consensus motif; other site 101510014950 AMP binding site [chemical binding]; other site 101510014951 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014952 Condensation domain; Region: Condensation; pfam00668 101510014953 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014954 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014955 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014956 acyl-activating enzyme (AAE) consensus motif; other site 101510014957 AMP binding site [chemical binding]; other site 101510014958 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014959 Condensation domain; Region: Condensation; pfam00668 101510014960 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510014961 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014962 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014963 acyl-activating enzyme (AAE) consensus motif; other site 101510014964 AMP binding site [chemical binding]; other site 101510014965 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014966 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510014967 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510014968 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510014969 acyl-activating enzyme (AAE) consensus motif; other site 101510014970 AMP binding site [chemical binding]; other site 101510014971 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510014972 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 101510014973 Chain length determinant protein; Region: Wzz; pfam02706 101510014974 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 101510014975 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510014976 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510014977 Low molecular weight phosphatase family; Region: LMWPc; cl00105 101510014978 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 101510014979 active site 101510014980 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 101510014981 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 101510014982 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 101510014983 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 101510014984 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 101510014985 Lipase (class 2); Region: Lipase_2; pfam01674 101510014986 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510014987 YibE/F-like protein; Region: YibE_F; pfam07907 101510014988 Helix-turn-helix domain; Region: HTH_31; pfam13560 101510014989 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510014990 aminotransferase AlaT; Validated; Region: PRK09265 101510014991 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510014992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510014993 homodimer interface [polypeptide binding]; other site 101510014994 catalytic residue [active] 101510014995 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 101510014996 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 101510014997 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510014998 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510014999 Condensation domain; Region: Condensation; pfam00668 101510015000 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510015001 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510015002 acyl-activating enzyme (AAE) consensus motif; other site 101510015003 AMP binding site [chemical binding]; other site 101510015004 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510015005 Condensation domain; Region: Condensation; pfam00668 101510015006 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510015007 Condensation domain; Region: Condensation; pfam00668 101510015008 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510015009 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510015010 acyl-activating enzyme (AAE) consensus motif; other site 101510015011 AMP binding site [chemical binding]; other site 101510015012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510015013 Condensation domain; Region: Condensation; pfam00668 101510015014 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510015015 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510015016 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510015017 acyl-activating enzyme (AAE) consensus motif; other site 101510015018 AMP binding site [chemical binding]; other site 101510015019 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510015020 Condensation domain; Region: Condensation; pfam00668 101510015021 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510015022 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510015023 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510015024 acyl-activating enzyme (AAE) consensus motif; other site 101510015025 AMP binding site [chemical binding]; other site 101510015026 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510015027 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510015028 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510015029 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510015030 acyl-activating enzyme (AAE) consensus motif; other site 101510015031 AMP binding site [chemical binding]; other site 101510015032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510015033 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 101510015034 G1 box; other site 101510015035 GTP/Mg2+ binding site [chemical binding]; other site 101510015036 G2 box; other site 101510015037 Switch I region; other site 101510015038 G3 box; other site 101510015039 Switch II region; other site 101510015040 G4 box; other site 101510015041 G5 box; other site 101510015042 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 101510015043 G1 box; other site 101510015044 GTP/Mg2+ binding site [chemical binding]; other site 101510015045 G2 box; other site 101510015046 Switch I region; other site 101510015047 G3 box; other site 101510015048 Switch II region; other site 101510015049 G4 box; other site 101510015050 G5 box; other site 101510015051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510015052 nucleotide binding site [chemical binding]; other site 101510015053 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 101510015054 4Fe-4S binding domain; Region: Fer4; pfam00037 101510015055 Cysteine-rich domain; Region: CCG; pfam02754 101510015056 Cysteine-rich domain; Region: CCG; pfam02754 101510015057 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 101510015058 Caleosin related protein; Region: Caleosin; pfam05042 101510015059 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 101510015060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510015061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510015062 DNA binding residues [nucleotide binding] 101510015063 dimerization interface [polypeptide binding]; other site 101510015064 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510015065 nucleotide binding site [chemical binding]; other site 101510015066 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 101510015067 G1 box; other site 101510015068 GTP/Mg2+ binding site [chemical binding]; other site 101510015069 G2 box; other site 101510015070 Switch I region; other site 101510015071 G3 box; other site 101510015072 Switch II region; other site 101510015073 G4 box; other site 101510015074 G5 box; other site 101510015075 Uncharacterized conserved protein (DUF2361); Region: DUF2361; pfam10153 101510015076 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 101510015077 Dynamin family; Region: Dynamin_N; pfam00350 101510015078 G1 box; other site 101510015079 GTP/Mg2+ binding site [chemical binding]; other site 101510015080 G2 box; other site 101510015081 Switch I region; other site 101510015082 G3 box; other site 101510015083 Switch II region; other site 101510015084 G4 box; other site 101510015085 G5 box; other site 101510015086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 101510015087 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 101510015088 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 101510015089 galactokinase; Provisional; Region: PRK00555 101510015090 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 101510015091 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 101510015092 dimer interface [polypeptide binding]; other site 101510015093 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 101510015094 active site 101510015095 Probable transposase; Region: OrfB_IS605; pfam01385 101510015096 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 101510015097 Protein of unknown function (DUF664); Region: DUF664; pfam04978 101510015098 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 101510015099 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 101510015100 nucleotide binding site [chemical binding]; other site 101510015101 NEF interaction site [polypeptide binding]; other site 101510015102 SBD interface [polypeptide binding]; other site 101510015103 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 101510015104 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 101510015105 dimer interface [polypeptide binding]; other site 101510015106 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 101510015107 chaperone protein DnaJ; Provisional; Region: PRK14290 101510015108 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 101510015109 HSP70 interaction site [polypeptide binding]; other site 101510015110 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 101510015111 Zn binding sites [ion binding]; other site 101510015112 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 101510015113 dimer interface [polypeptide binding]; other site 101510015114 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 101510015115 DNA binding residues [nucleotide binding] 101510015116 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510015117 putative dimer interface [polypeptide binding]; other site 101510015118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510015119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510015120 active site 101510015121 phosphorylation site [posttranslational modification] 101510015122 intermolecular recognition site; other site 101510015123 dimerization interface [polypeptide binding]; other site 101510015124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510015125 DNA binding residues [nucleotide binding] 101510015126 dimerization interface [polypeptide binding]; other site 101510015127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510015128 Histidine kinase; Region: HisKA_3; pfam07730 101510015129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510015130 ATP binding site [chemical binding]; other site 101510015131 Mg2+ binding site [ion binding]; other site 101510015132 G-X-G motif; other site 101510015133 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 101510015134 intracellular protease, PfpI family; Region: PfpI; TIGR01382 101510015135 proposed catalytic triad [active] 101510015136 conserved cys residue [active] 101510015137 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 101510015138 hydroxyglutarate oxidase; Provisional; Region: PRK11728 101510015139 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510015140 iron-sulfur cluster [ion binding]; other site 101510015141 [2Fe-2S] cluster binding site [ion binding]; other site 101510015142 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 101510015143 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510015144 NAD binding site [chemical binding]; other site 101510015145 catalytic Zn binding site [ion binding]; other site 101510015146 structural Zn binding site [ion binding]; other site 101510015147 ChaB; Region: ChaB; pfam06150 101510015148 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 101510015149 Competence-damaged protein; Region: CinA; pfam02464 101510015150 acyl-CoA synthetase; Validated; Region: PRK06188 101510015151 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510015152 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510015153 acyl-activating enzyme (AAE) consensus motif; other site 101510015154 putative AMP binding site [chemical binding]; other site 101510015155 putative active site [active] 101510015156 putative CoA binding site [chemical binding]; other site 101510015157 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 101510015158 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 101510015159 heme-binding site [chemical binding]; other site 101510015160 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 101510015161 FAD binding pocket [chemical binding]; other site 101510015162 FAD binding motif [chemical binding]; other site 101510015163 phosphate binding motif [ion binding]; other site 101510015164 beta-alpha-beta structure motif; other site 101510015165 NAD binding pocket [chemical binding]; other site 101510015166 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 101510015167 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 101510015168 FAD binding pocket [chemical binding]; other site 101510015169 FAD binding motif [chemical binding]; other site 101510015170 phosphate binding motif [ion binding]; other site 101510015171 beta-alpha-beta structure motif; other site 101510015172 NAD binding pocket [chemical binding]; other site 101510015173 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 101510015174 heme-binding site [chemical binding]; other site 101510015175 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 101510015176 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 101510015177 FAD binding pocket [chemical binding]; other site 101510015178 FAD binding motif [chemical binding]; other site 101510015179 phosphate binding motif [ion binding]; other site 101510015180 beta-alpha-beta structure motif; other site 101510015181 NAD binding pocket [chemical binding]; other site 101510015182 S-formylglutathione hydrolase; Region: PLN02442 101510015183 Putative esterase; Region: Esterase; pfam00756 101510015184 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 101510015185 Clp amino terminal domain; Region: Clp_N; pfam02861 101510015186 Clp amino terminal domain; Region: Clp_N; pfam02861 101510015187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510015188 Walker A motif; other site 101510015189 ATP binding site [chemical binding]; other site 101510015190 Walker B motif; other site 101510015191 arginine finger; other site 101510015192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510015193 Walker A motif; other site 101510015194 ATP binding site [chemical binding]; other site 101510015195 Walker B motif; other site 101510015196 arginine finger; other site 101510015197 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 101510015198 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 101510015199 classical (c) SDRs; Region: SDR_c; cd05233 101510015200 NAD(P) binding site [chemical binding]; other site 101510015201 active site 101510015202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510015203 active site 101510015204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510015205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510015206 putative substrate translocation pore; other site 101510015207 MarR family; Region: MarR; pfam01047 101510015208 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510015209 hydrophobic ligand binding site; other site 101510015210 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510015211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510015212 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 101510015213 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 101510015214 benzoate transporter; Region: benE; TIGR00843 101510015215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510015216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510015217 YhhN-like protein; Region: YhhN; pfam07947 101510015218 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 101510015219 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 101510015220 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 101510015221 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 101510015222 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 101510015223 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 101510015224 active site 101510015225 non-prolyl cis peptide bond; other site 101510015226 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 101510015227 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 101510015228 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 101510015229 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 101510015230 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 101510015231 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 101510015232 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 101510015233 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 101510015234 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 101510015235 active site 101510015236 intersubunit interface [polypeptide binding]; other site 101510015237 zinc binding site [ion binding]; other site 101510015238 Na+ binding site [ion binding]; other site 101510015239 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 101510015240 Predicted membrane protein [Function unknown]; Region: COG4129 101510015241 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 101510015242 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 101510015243 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 101510015244 Predicted transcriptional regulator [Transcription]; Region: COG2378 101510015245 HTH domain; Region: HTH_11; pfam08279 101510015246 WYL domain; Region: WYL; pfam13280 101510015247 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 101510015248 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510015249 dimer interface [polypeptide binding]; other site 101510015250 active site 101510015251 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510015252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510015253 putative substrate translocation pore; other site 101510015254 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 101510015255 Moco binding site; other site 101510015256 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 101510015257 metal coordination site [ion binding]; other site 101510015258 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 101510015259 FAD binding pocket [chemical binding]; other site 101510015260 FAD binding motif [chemical binding]; other site 101510015261 phosphate binding motif [ion binding]; other site 101510015262 beta-alpha-beta structure motif; other site 101510015263 NAD binding pocket [chemical binding]; other site 101510015264 Predicted transcriptional regulators [Transcription]; Region: COG1733 101510015265 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 101510015266 Peptidase family M50; Region: Peptidase_M50; pfam02163 101510015267 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 101510015268 active site 101510015269 putative substrate binding region [chemical binding]; other site 101510015270 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 101510015271 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 101510015272 GDP-binding site [chemical binding]; other site 101510015273 ACT binding site; other site 101510015274 IMP binding site; other site 101510015275 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 101510015276 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 101510015277 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 101510015278 active site 101510015279 DNA binding site [nucleotide binding] 101510015280 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 101510015281 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 101510015282 putative active site [active] 101510015283 putative metal binding site [ion binding]; other site 101510015284 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 101510015285 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 101510015286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510015287 DNA-binding site [nucleotide binding]; DNA binding site 101510015288 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510015289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510015290 homodimer interface [polypeptide binding]; other site 101510015291 catalytic residue [active] 101510015292 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510015293 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510015294 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510015295 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510015296 active site 101510015297 short chain dehydrogenase; Provisional; Region: PRK06197 101510015298 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 101510015299 putative NAD(P) binding site [chemical binding]; other site 101510015300 active site 101510015301 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510015302 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 101510015303 substrate binding pocket [chemical binding]; other site 101510015304 catalytic triad [active] 101510015305 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 101510015306 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510015307 substrate binding pocket [chemical binding]; other site 101510015308 catalytic triad [active] 101510015309 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 101510015310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510015311 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 101510015312 short chain dehydrogenase; Provisional; Region: PRK08251 101510015313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510015314 NAD(P) binding site [chemical binding]; other site 101510015315 active site 101510015316 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510015317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510015318 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510015319 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 101510015320 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 101510015321 active site 101510015322 dimer interface [polypeptide binding]; other site 101510015323 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 101510015324 dimer interface [polypeptide binding]; other site 101510015325 active site 101510015326 succinic semialdehyde dehydrogenase; Region: PLN02278 101510015327 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 101510015328 tetramerization interface [polypeptide binding]; other site 101510015329 NAD(P) binding site [chemical binding]; other site 101510015330 catalytic residues [active] 101510015331 hypothetical protein; Provisional; Region: PRK07857 101510015332 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 101510015333 Part of AAA domain; Region: AAA_19; pfam13245 101510015334 Family description; Region: UvrD_C_2; pfam13538 101510015335 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510015336 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510015337 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 101510015338 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 101510015339 CoA-ligase; Region: Ligase_CoA; pfam00549 101510015340 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 101510015341 CoA binding domain; Region: CoA_binding; smart00881 101510015342 CoA-ligase; Region: Ligase_CoA; pfam00549 101510015343 Uncharacterized conserved protein [Function unknown]; Region: COG1739 101510015344 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 101510015345 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 101510015346 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 101510015347 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 101510015348 active site 101510015349 substrate binding site [chemical binding]; other site 101510015350 cosubstrate binding site; other site 101510015351 catalytic site [active] 101510015352 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 101510015353 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 101510015354 purine monophosphate binding site [chemical binding]; other site 101510015355 dimer interface [polypeptide binding]; other site 101510015356 putative catalytic residues [active] 101510015357 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 101510015358 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 101510015359 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 101510015360 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 101510015361 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 101510015362 active site 101510015363 metal binding site [ion binding]; metal-binding site 101510015364 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510015365 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510015366 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 101510015367 Predicted transcriptional regulators [Transcription]; Region: COG1733 101510015368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510015369 dimerization interface [polypeptide binding]; other site 101510015370 putative DNA binding site [nucleotide binding]; other site 101510015371 putative Zn2+ binding site [ion binding]; other site 101510015372 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 101510015373 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510015374 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 101510015375 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 101510015376 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 101510015377 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 101510015378 metal ion-dependent adhesion site (MIDAS); other site 101510015379 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 101510015380 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 101510015381 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 101510015382 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 101510015383 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 101510015384 active site 101510015385 catalytic triad [active] 101510015386 dimer interface [polypeptide binding]; other site 101510015387 tetracycline repressor protein TetR; Provisional; Region: PRK13756 101510015388 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 101510015389 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510015390 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510015391 Ligand Binding Site [chemical binding]; other site 101510015392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510015393 Ligand Binding Site [chemical binding]; other site 101510015394 succinic semialdehyde dehydrogenase; Region: PLN02278 101510015395 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 101510015396 tetramerization interface [polypeptide binding]; other site 101510015397 NAD(P) binding site [chemical binding]; other site 101510015398 catalytic residues [active] 101510015399 tyramine oxidase; Provisional; Region: tynA; PRK11504 101510015400 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 101510015401 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 101510015402 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 101510015403 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 101510015404 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510015405 inhibitor-cofactor binding pocket; inhibition site 101510015406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510015407 catalytic residue [active] 101510015408 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 101510015409 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 101510015410 tetrameric interface [polypeptide binding]; other site 101510015411 NAD binding site [chemical binding]; other site 101510015412 catalytic residues [active] 101510015413 substrate binding site [chemical binding]; other site 101510015414 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510015415 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 101510015416 active site 101510015417 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510015418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510015419 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510015420 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 101510015421 active site 101510015422 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 101510015423 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510015424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510015425 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 101510015426 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 101510015427 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 101510015428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510015429 Predicted permeases [General function prediction only]; Region: COG0679 101510015430 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510015431 Beta-lactamase; Region: Beta-lactamase; cl17358 101510015432 Domain of unknown function (DUF305); Region: DUF305; pfam03713 101510015433 30S ribosomal protein S18; Provisional; Region: PRK13401 101510015434 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 101510015435 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 101510015436 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 101510015437 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 101510015438 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 101510015439 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 101510015440 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 101510015441 Predicted membrane protein [Function unknown]; Region: COG2860 101510015442 UPF0126 domain; Region: UPF0126; pfam03458 101510015443 UPF0126 domain; Region: UPF0126; pfam03458 101510015444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510015445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510015446 active site 101510015447 phosphorylation site [posttranslational modification] 101510015448 intermolecular recognition site; other site 101510015449 dimerization interface [polypeptide binding]; other site 101510015450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510015451 DNA binding site [nucleotide binding] 101510015452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510015453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510015454 dimerization interface [polypeptide binding]; other site 101510015455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510015456 dimer interface [polypeptide binding]; other site 101510015457 phosphorylation site [posttranslational modification] 101510015458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510015459 ATP binding site [chemical binding]; other site 101510015460 Mg2+ binding site [ion binding]; other site 101510015461 G-X-G motif; other site 101510015462 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 101510015463 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 101510015464 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 101510015465 MPT binding site; other site 101510015466 trimer interface [polypeptide binding]; other site 101510015467 MspA; Region: MspA; pfam09203 101510015468 MspA; Region: MspA; pfam09203 101510015469 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 101510015470 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 101510015471 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 101510015472 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 101510015473 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 101510015474 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 101510015475 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 101510015476 active site 101510015477 tetramer interface; other site 101510015478 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 101510015479 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 101510015480 dimer interface [polypeptide binding]; other site 101510015481 putative functional site; other site 101510015482 putative MPT binding site; other site 101510015483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 101510015484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 101510015485 Domain of unknown function (DUF955); Region: DUF955; pfam06114 101510015486 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 101510015487 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 101510015488 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 101510015489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510015490 sequence-specific DNA binding site [nucleotide binding]; other site 101510015491 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510015492 salt bridge; other site 101510015493 short chain dehydrogenase; Provisional; Region: PRK07832 101510015494 classical (c) SDRs; Region: SDR_c; cd05233 101510015495 NAD(P) binding site [chemical binding]; other site 101510015496 active site 101510015497 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510015498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 101510015499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510015500 Walker A/P-loop; other site 101510015501 ATP binding site [chemical binding]; other site 101510015502 Q-loop/lid; other site 101510015503 ABC transporter signature motif; other site 101510015504 Walker B; other site 101510015505 D-loop; other site 101510015506 H-loop/switch region; other site 101510015507 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 101510015508 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 101510015509 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 101510015510 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 101510015511 putative acyl-acceptor binding pocket; other site 101510015512 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 101510015513 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 101510015514 putative acyl-acceptor binding pocket; other site 101510015515 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510015516 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510015517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 101510015518 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 101510015519 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 101510015520 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510015521 DNA binding residues [nucleotide binding] 101510015522 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 101510015523 heme-binding site [chemical binding]; other site 101510015524 arginine deiminase; Provisional; Region: PRK01388 101510015525 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 101510015526 ArsC family; Region: ArsC; pfam03960 101510015527 catalytic residues [active] 101510015528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510015529 NADH(P)-binding; Region: NAD_binding_10; pfam13460 101510015530 NAD(P) binding site [chemical binding]; other site 101510015531 active site 101510015532 Predicted transcriptional regulators [Transcription]; Region: COG1725 101510015533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510015534 DNA-binding site [nucleotide binding]; DNA binding site 101510015535 Predicted membrane protein [Function unknown]; Region: COG2259 101510015536 BCCT family transporter; Region: BCCT; pfam02028 101510015537 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 101510015538 Predicted methyltransferases [General function prediction only]; Region: COG0313 101510015539 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 101510015540 putative SAM binding site [chemical binding]; other site 101510015541 putative homodimer interface [polypeptide binding]; other site 101510015542 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 101510015543 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 101510015544 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 101510015545 active site 101510015546 HIGH motif; other site 101510015547 KMSKS motif; other site 101510015548 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 101510015549 tRNA binding surface [nucleotide binding]; other site 101510015550 anticodon binding site; other site 101510015551 short chain dehydrogenase; Provisional; Region: PRK07825 101510015552 classical (c) SDRs; Region: SDR_c; cd05233 101510015553 NAD(P) binding site [chemical binding]; other site 101510015554 active site 101510015555 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 101510015556 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 101510015557 active site 101510015558 Predicted membrane protein [Function unknown]; Region: COG2259 101510015559 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510015560 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510015561 Walker A/P-loop; other site 101510015562 ATP binding site [chemical binding]; other site 101510015563 Q-loop/lid; other site 101510015564 ABC transporter signature motif; other site 101510015565 Walker B; other site 101510015566 D-loop; other site 101510015567 H-loop/switch region; other site 101510015568 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510015569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510015570 substrate binding pocket [chemical binding]; other site 101510015571 membrane-bound complex binding site; other site 101510015572 hinge residues; other site 101510015573 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 101510015574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510015575 dimer interface [polypeptide binding]; other site 101510015576 conserved gate region; other site 101510015577 putative PBP binding loops; other site 101510015578 ABC-ATPase subunit interface; other site 101510015579 Domain of unknown function (DUF348); Region: DUF348; pfam03990 101510015580 Domain of unknown function (DUF348); Region: DUF348; pfam03990 101510015581 G5 domain; Region: G5; pfam07501 101510015582 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 101510015583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 101510015584 Domain of unknown function (DUF348); Region: DUF348; pfam03990 101510015585 Domain of unknown function (DUF348); Region: DUF348; pfam03990 101510015586 Domain of unknown function (DUF348); Region: DUF348; pfam03990 101510015587 G5 domain; Region: G5; pfam07501 101510015588 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 101510015589 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 101510015590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510015591 S-adenosylmethionine binding site [chemical binding]; other site 101510015592 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 101510015593 DNA-binding site [nucleotide binding]; DNA binding site 101510015594 RNA-binding motif; other site 101510015595 HTH domain; Region: HTH_11; pfam08279 101510015596 Predicted transcriptional regulator [Transcription]; Region: COG2378 101510015597 WYL domain; Region: WYL; pfam13280 101510015598 Uncharacterized conserved protein [Function unknown]; Region: COG1434 101510015599 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 101510015600 putative active site [active] 101510015601 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 101510015602 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 101510015603 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 101510015604 alpha-gamma subunit interface [polypeptide binding]; other site 101510015605 beta-gamma subunit interface [polypeptide binding]; other site 101510015606 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 101510015607 gamma-beta subunit interface [polypeptide binding]; other site 101510015608 alpha-beta subunit interface [polypeptide binding]; other site 101510015609 urease subunit alpha; Reviewed; Region: ureC; PRK13206 101510015610 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 101510015611 subunit interactions [polypeptide binding]; other site 101510015612 active site 101510015613 flap region; other site 101510015614 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 101510015615 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510015616 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 101510015617 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 101510015618 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 101510015619 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 101510015620 ABC transporter; Region: ABC_tran_2; pfam12848 101510015621 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 101510015622 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 101510015623 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 101510015624 active site 101510015625 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510015626 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 101510015627 putative dimer interface [polypeptide binding]; other site 101510015628 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510015629 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 101510015630 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 101510015631 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 101510015632 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 101510015633 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 101510015634 G1 box; other site 101510015635 putative GEF interaction site [polypeptide binding]; other site 101510015636 GTP/Mg2+ binding site [chemical binding]; other site 101510015637 Switch I region; other site 101510015638 G2 box; other site 101510015639 G3 box; other site 101510015640 Switch II region; other site 101510015641 G4 box; other site 101510015642 G5 box; other site 101510015643 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 101510015644 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 101510015645 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 101510015646 acyl-activating enzyme (AAE) consensus motif; other site 101510015647 active site 101510015648 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 101510015649 putative active site [active] 101510015650 catalytic residue [active] 101510015651 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 101510015652 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 101510015653 5S rRNA interface [nucleotide binding]; other site 101510015654 CTC domain interface [polypeptide binding]; other site 101510015655 L16 interface [polypeptide binding]; other site 101510015656 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510015657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510015658 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510015659 hypothetical protein; Validated; Region: PRK07121 101510015660 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510015661 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 101510015662 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510015663 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510015664 catalytic residue [active] 101510015665 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 101510015666 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 101510015667 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 101510015668 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 101510015669 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 101510015670 putative active site [active] 101510015671 putative dimer interface [polypeptide binding]; other site 101510015672 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 101510015673 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 101510015674 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 101510015675 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 101510015676 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 101510015677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510015678 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 101510015679 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510015680 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510015681 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 101510015682 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 101510015683 putative active site [active] 101510015684 putative FMN binding site [chemical binding]; other site 101510015685 putative substrate binding site [chemical binding]; other site 101510015686 putative catalytic residue [active] 101510015687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510015688 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 101510015689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510015690 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510015691 hypothetical protein; Provisional; Region: PRK07524 101510015692 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510015693 PYR/PP interface [polypeptide binding]; other site 101510015694 dimer interface [polypeptide binding]; other site 101510015695 TPP binding site [chemical binding]; other site 101510015696 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510015697 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 101510015698 TPP-binding site [chemical binding]; other site 101510015699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510015700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510015701 active site 101510015702 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 101510015703 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510015704 NAD binding site [chemical binding]; other site 101510015705 catalytic residues [active] 101510015706 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 101510015707 short chain dehydrogenase; Provisional; Region: PRK07677 101510015708 NAD(P) binding site [chemical binding]; other site 101510015709 substrate binding site [chemical binding]; other site 101510015710 homotetramer interface [polypeptide binding]; other site 101510015711 active site 101510015712 homodimer interface [polypeptide binding]; other site 101510015713 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 101510015714 CoA binding domain; Region: CoA_binding_2; pfam13380 101510015715 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 101510015716 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 101510015717 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510015718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510015719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510015720 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510015721 Cytochrome P450; Region: p450; cl12078 101510015722 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 101510015723 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 101510015724 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 101510015725 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510015726 active site 101510015727 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 101510015728 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 101510015729 Substrate binding site; other site 101510015730 Mg++ binding site; other site 101510015731 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 101510015732 active site 101510015733 substrate binding site [chemical binding]; other site 101510015734 CoA binding site [chemical binding]; other site 101510015735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510015736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510015737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510015738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510015739 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 101510015740 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510015741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510015742 catalytic residue [active] 101510015743 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 101510015744 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 101510015745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 101510015746 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 101510015747 putative ADP-binding pocket [chemical binding]; other site 101510015748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510015749 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 101510015750 putative active site [active] 101510015751 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 101510015752 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 101510015753 Chain length determinant protein; Region: Wzz; cl15801 101510015754 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 101510015755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 101510015756 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 101510015757 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 101510015758 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 101510015759 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510015760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510015761 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510015762 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 101510015763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510015764 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 101510015765 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 101510015766 active site 101510015767 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 101510015768 Bacterial sugar transferase; Region: Bac_transf; pfam02397 101510015769 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 101510015770 Methyltransferase domain; Region: Methyltransf_23; pfam13489 101510015771 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 101510015772 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 101510015773 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 101510015774 extended (e) SDRs; Region: SDR_e; cd08946 101510015775 NAD(P) binding site [chemical binding]; other site 101510015776 active site 101510015777 substrate binding site [chemical binding]; other site 101510015778 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 101510015779 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 101510015780 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510015781 active site 101510015782 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 101510015783 Methyltransferase domain; Region: Methyltransf_23; pfam13489 101510015784 Methyltransferase domain; Region: Methyltransf_12; pfam08242 101510015785 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 101510015786 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 101510015787 hypothetical protein; Provisional; Region: PRK07877 101510015788 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 101510015789 ATP binding site [chemical binding]; other site 101510015790 substrate interface [chemical binding]; other site 101510015791 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 101510015792 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510015793 metal binding site [ion binding]; metal-binding site 101510015794 active site 101510015795 I-site; other site 101510015796 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 101510015797 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 101510015798 acyl carrier protein; Provisional; Region: PRK07081 101510015799 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510015800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510015801 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 101510015802 dimer interface [polypeptide binding]; other site 101510015803 motif 1; other site 101510015804 active site 101510015805 motif 2; other site 101510015806 motif 3; other site 101510015807 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 101510015808 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 101510015809 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 101510015810 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 101510015811 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510015812 ATP binding site [chemical binding]; other site 101510015813 putative Mg++ binding site [ion binding]; other site 101510015814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510015815 nucleotide binding region [chemical binding]; other site 101510015816 ATP-binding site [chemical binding]; other site 101510015817 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 101510015818 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 101510015819 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 101510015820 homodimer interface [polypeptide binding]; other site 101510015821 metal binding site [ion binding]; metal-binding site 101510015822 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 101510015823 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 101510015824 Ligand binding site; other site 101510015825 Putative Catalytic site; other site 101510015826 DXD motif; other site 101510015827 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 101510015828 DXD motif; other site 101510015829 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 101510015830 Probable Catalytic site; other site 101510015831 metal-binding site 101510015832 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510015833 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510015834 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 101510015835 active site 101510015836 catalytic residues [active] 101510015837 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 101510015838 active site 101510015839 catalytic residues [active] 101510015840 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 101510015841 putative catalytic motif [active] 101510015842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 101510015843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510015844 metal binding site [ion binding]; metal-binding site 101510015845 active site 101510015846 I-site; other site 101510015847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510015848 metal binding site [ion binding]; metal-binding site 101510015849 active site 101510015850 I-site; other site 101510015851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 101510015852 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 101510015853 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 101510015854 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 101510015855 Imelysin; Region: Peptidase_M75; pfam09375 101510015856 Iron permease FTR1 family; Region: FTR1; cl00475 101510015857 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 101510015858 enolase; Provisional; Region: eno; PRK00077 101510015859 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 101510015860 dimer interface [polypeptide binding]; other site 101510015861 metal binding site [ion binding]; metal-binding site 101510015862 substrate binding pocket [chemical binding]; other site 101510015863 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 101510015864 Septum formation initiator; Region: DivIC; pfam04977 101510015865 Uncharacterized conserved protein [Function unknown]; Region: COG1507 101510015866 exopolyphosphatase; Region: exo_poly_only; TIGR03706 101510015867 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 101510015868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510015869 S-adenosylmethionine binding site [chemical binding]; other site 101510015870 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 101510015871 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 101510015872 putative active site [active] 101510015873 putative metal binding site [ion binding]; other site 101510015874 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510015875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510015876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510015877 MarR family; Region: MarR; pfam01047 101510015878 MarR family; Region: MarR_2; cl17246 101510015879 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510015880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510015881 NAD(P) binding site [chemical binding]; other site 101510015882 active site 101510015883 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510015884 classical (c) SDRs; Region: SDR_c; cd05233 101510015885 NAD(P) binding site [chemical binding]; other site 101510015886 active site 101510015887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510015888 NAD(P) binding site [chemical binding]; other site 101510015889 active site 101510015890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510015891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510015892 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510015893 SnoaL-like domain; Region: SnoaL_3; pfam13474 101510015894 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510015895 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510015896 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510015897 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510015898 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510015899 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510015900 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 101510015901 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510015902 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 101510015903 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510015904 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 101510015905 acetaldehyde dehydrogenase; Validated; Region: PRK08300 101510015906 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510015907 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 101510015908 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 101510015909 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 101510015910 active site 101510015911 catalytic residues [active] 101510015912 metal binding site [ion binding]; metal-binding site 101510015913 DmpG-like communication domain; Region: DmpG_comm; pfam07836 101510015914 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510015915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510015916 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 101510015917 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 101510015918 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 101510015919 active site 101510015920 Fe binding site [ion binding]; other site 101510015921 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510015922 Secretory lipase; Region: LIP; pfam03583 101510015923 Domain of unknown function (DUF427); Region: DUF427; cl00998 101510015924 Domain of unknown function (DUF427); Region: DUF427; pfam04248 101510015925 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 101510015926 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510015927 Serine hydrolase; Region: Ser_hydrolase; cl17834 101510015928 short chain dehydrogenase; Provisional; Region: PRK06523 101510015929 classical (c) SDRs; Region: SDR_c; cd05233 101510015930 NAD(P) binding site [chemical binding]; other site 101510015931 active site 101510015932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510015933 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510015934 NAD(P) binding site [chemical binding]; other site 101510015935 active site 101510015936 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510015937 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 101510015938 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510015939 hydrophobic ligand binding site; other site 101510015940 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510015941 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510015942 active site 101510015943 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 101510015944 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510015945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510015946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510015947 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 101510015948 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510015949 dimer interface [polypeptide binding]; other site 101510015950 active site 101510015951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510015952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510015953 active site 101510015954 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510015955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510015956 active site 101510015957 enoyl-CoA hydratase; Region: PLN02864 101510015958 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 101510015959 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 101510015960 dimer interaction site [polypeptide binding]; other site 101510015961 substrate-binding tunnel; other site 101510015962 active site 101510015963 catalytic site [active] 101510015964 substrate binding site [chemical binding]; other site 101510015965 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510015966 CoenzymeA binding site [chemical binding]; other site 101510015967 subunit interaction site [polypeptide binding]; other site 101510015968 PHB binding site; other site 101510015969 classical (c) SDRs; Region: SDR_c; cd05233 101510015970 NAD(P) binding site [chemical binding]; other site 101510015971 active site 101510015972 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 101510015973 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510015974 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 101510015975 acyl-activating enzyme (AAE) consensus motif; other site 101510015976 acyl-activating enzyme (AAE) consensus motif; other site 101510015977 putative AMP binding site [chemical binding]; other site 101510015978 putative active site [active] 101510015979 putative CoA binding site [chemical binding]; other site 101510015980 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510015981 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 101510015982 active site 101510015983 FMN binding site [chemical binding]; other site 101510015984 substrate binding site [chemical binding]; other site 101510015985 putative catalytic residue [active] 101510015986 acyl-CoA synthetase; Provisional; Region: PRK13388 101510015987 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510015988 acyl-activating enzyme (AAE) consensus motif; other site 101510015989 AMP binding site [chemical binding]; other site 101510015990 active site 101510015991 CoA binding site [chemical binding]; other site 101510015992 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510015993 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510015994 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 101510015995 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510015996 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510015997 active site 101510015998 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510015999 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 101510016000 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510016001 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510016002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510016003 active site 101510016004 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 101510016005 putative active site [active] 101510016006 putative catalytic site [active] 101510016007 lipid-transfer protein; Provisional; Region: PRK07855 101510016008 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510016009 active site 101510016010 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510016011 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510016012 active site 2 [active] 101510016013 active site 1 [active] 101510016014 short chain dehydrogenase; Provisional; Region: PRK07856 101510016015 classical (c) SDRs; Region: SDR_c; cd05233 101510016016 NAD(P) binding site [chemical binding]; other site 101510016017 active site 101510016018 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510016019 classical (c) SDRs; Region: SDR_c; cd05233 101510016020 NAD(P) binding site [chemical binding]; other site 101510016021 active site 101510016022 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 101510016023 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 101510016024 FAD binding pocket [chemical binding]; other site 101510016025 FAD binding motif [chemical binding]; other site 101510016026 phosphate binding motif [ion binding]; other site 101510016027 beta-alpha-beta structure motif; other site 101510016028 NAD(p) ribose binding residues [chemical binding]; other site 101510016029 NAD binding pocket [chemical binding]; other site 101510016030 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 101510016031 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510016032 catalytic loop [active] 101510016033 iron binding site [ion binding]; other site 101510016034 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 101510016035 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 101510016036 putative active site [active] 101510016037 putative dimer interface [polypeptide binding]; other site 101510016038 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 101510016039 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 101510016040 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 101510016041 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 101510016042 tetramer interface [polypeptide binding]; other site 101510016043 heme binding pocket [chemical binding]; other site 101510016044 NADPH binding site [chemical binding]; other site 101510016045 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510016046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510016047 active site 101510016048 ATP binding site [chemical binding]; other site 101510016049 substrate binding site [chemical binding]; other site 101510016050 activation loop (A-loop); other site 101510016051 AAA ATPase domain; Region: AAA_16; pfam13191 101510016052 AAA domain; Region: AAA_22; pfam13401 101510016053 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 101510016054 putative FMN binding site [chemical binding]; other site 101510016055 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 101510016056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510016057 S-adenosylmethionine binding site [chemical binding]; other site 101510016058 Bax inhibitor 1 like; Region: BaxI_1; cl17691 101510016059 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 101510016060 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510016061 dimer interface [polypeptide binding]; other site 101510016062 active site 101510016063 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 101510016064 active site 101510016065 catalytic triad [active] 101510016066 oxyanion hole [active] 101510016067 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 101510016068 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 101510016069 dimer interface [polypeptide binding]; other site 101510016070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510016071 catalytic residue [active] 101510016072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 101510016073 cystathionine gamma-synthase; Provisional; Region: PRK07811 101510016074 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 101510016075 homodimer interface [polypeptide binding]; other site 101510016076 substrate-cofactor binding pocket; other site 101510016077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510016078 catalytic residue [active] 101510016079 threonine dehydratase; Provisional; Region: PRK08198 101510016080 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 101510016081 tetramer interface [polypeptide binding]; other site 101510016082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510016083 catalytic residue [active] 101510016084 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 101510016085 ApbE family; Region: ApbE; pfam02424 101510016086 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 101510016087 N-acetyl-D-glucosamine binding site [chemical binding]; other site 101510016088 catalytic residue [active] 101510016089 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510016090 NlpC/P60 family; Region: NLPC_P60; pfam00877 101510016091 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 101510016092 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 101510016093 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 101510016094 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 101510016095 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 101510016096 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 101510016097 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 101510016098 catalytic residues [active] 101510016099 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 101510016100 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 101510016101 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 101510016102 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 101510016103 catalytic residue [active] 101510016104 putative FPP diphosphate binding site; other site 101510016105 putative FPP binding hydrophobic cleft; other site 101510016106 dimer interface [polypeptide binding]; other site 101510016107 putative IPP diphosphate binding site; other site 101510016108 pantothenate kinase; Provisional; Region: PRK05439 101510016109 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 101510016110 ATP-binding site [chemical binding]; other site 101510016111 CoA-binding site [chemical binding]; other site 101510016112 Mg2+-binding site [ion binding]; other site 101510016113 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 101510016114 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 101510016115 dimer interface [polypeptide binding]; other site 101510016116 active site 101510016117 glycine-pyridoxal phosphate binding site [chemical binding]; other site 101510016118 folate binding site [chemical binding]; other site 101510016119 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 101510016120 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 101510016121 putative active site [active] 101510016122 PhoH-like protein; Region: PhoH; pfam02562 101510016123 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510016124 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510016125 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510016126 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 101510016127 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 101510016128 dinuclear metal binding motif [ion binding]; other site 101510016129 fumarate hydratase; Reviewed; Region: fumC; PRK00485 101510016130 Class II fumarases; Region: Fumarase_classII; cd01362 101510016131 active site 101510016132 tetramer interface [polypeptide binding]; other site 101510016133 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 101510016134 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 101510016135 putative active site [active] 101510016136 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 101510016137 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 101510016138 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 101510016139 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 101510016140 generic binding surface II; other site 101510016141 generic binding surface I; other site 101510016142 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 101510016143 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 101510016144 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 101510016145 RmuC family; Region: RmuC; pfam02646 101510016146 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 101510016147 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 101510016148 active site 101510016149 metal binding site [ion binding]; metal-binding site 101510016150 DNA binding site [nucleotide binding] 101510016151 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 101510016152 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 101510016153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510016154 Walker A/P-loop; other site 101510016155 ATP binding site [chemical binding]; other site 101510016156 Q-loop/lid; other site 101510016157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510016158 Walker B; other site 101510016159 D-loop; other site 101510016160 H-loop/switch region; other site 101510016161 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 101510016162 carbon starvation protein A; Provisional; Region: PRK15015 101510016163 Carbon starvation protein CstA; Region: CstA; pfam02554 101510016164 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 101510016165 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 101510016166 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 101510016167 active site 101510016168 FMN binding site [chemical binding]; other site 101510016169 substrate binding site [chemical binding]; other site 101510016170 3Fe-4S cluster binding site [ion binding]; other site 101510016171 Interferon-induced transmembrane protein; Region: CD225; pfam04505 101510016172 GTP-binding protein YchF; Reviewed; Region: PRK09601 101510016173 YchF GTPase; Region: YchF; cd01900 101510016174 G1 box; other site 101510016175 GTP/Mg2+ binding site [chemical binding]; other site 101510016176 Switch I region; other site 101510016177 G2 box; other site 101510016178 Switch II region; other site 101510016179 G3 box; other site 101510016180 G4 box; other site 101510016181 G5 box; other site 101510016182 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 101510016183 Predicted transcriptional regulators [Transcription]; Region: COG1733 101510016184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510016185 putative Zn2+ binding site [ion binding]; other site 101510016186 putative DNA binding site [nucleotide binding]; other site 101510016187 PE-PPE domain; Region: PE-PPE; pfam08237 101510016188 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 101510016189 Cupin domain; Region: Cupin_2; cl17218 101510016190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510016191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510016192 DNA binding residues [nucleotide binding] 101510016193 dimerization interface [polypeptide binding]; other site 101510016194 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 101510016195 elongation factor G; Reviewed; Region: PRK12740 101510016196 G1 box; other site 101510016197 putative GEF interaction site [polypeptide binding]; other site 101510016198 GTP/Mg2+ binding site [chemical binding]; other site 101510016199 Switch I region; other site 101510016200 G2 box; other site 101510016201 G3 box; other site 101510016202 Switch II region; other site 101510016203 G4 box; other site 101510016204 G5 box; other site 101510016205 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 101510016206 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 101510016207 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 101510016208 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 101510016209 putative hydrophobic ligand binding site [chemical binding]; other site 101510016210 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 101510016211 putative active site [active] 101510016212 putative metal binding site [ion binding]; other site 101510016213 Fic/DOC family; Region: Fic; cl00960 101510016214 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 101510016215 heat shock protein 90; Provisional; Region: PRK05218 101510016216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510016217 ATP binding site [chemical binding]; other site 101510016218 Mg2+ binding site [ion binding]; other site 101510016219 G-X-G motif; other site 101510016220 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 101510016221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510016222 NAD(P) binding site [chemical binding]; other site 101510016223 active site 101510016224 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 101510016225 active site 101510016226 SUMO-1 interface [polypeptide binding]; other site 101510016227 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 101510016228 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510016229 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510016230 active site 101510016231 Methyltransferase domain; Region: Methyltransf_23; pfam13489 101510016232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510016233 S-adenosylmethionine binding site [chemical binding]; other site 101510016234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 101510016235 fumarate hydratase; Provisional; Region: PRK15389 101510016236 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 101510016237 Fumarase C-terminus; Region: Fumerase_C; pfam05683 101510016238 CAAX protease self-immunity; Region: Abi; pfam02517 101510016239 PGAP1-like protein; Region: PGAP1; pfam07819 101510016240 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 101510016241 ligand binding site [chemical binding]; other site 101510016242 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 101510016243 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510016244 putative active site [active] 101510016245 putative FMN binding site [chemical binding]; other site 101510016246 putative substrate binding site [chemical binding]; other site 101510016247 putative catalytic residue [active] 101510016248 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510016249 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 101510016250 active site 101510016251 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 101510016252 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 101510016253 Cl- selectivity filter; other site 101510016254 Cl- binding residues [ion binding]; other site 101510016255 pore gating glutamate residue; other site 101510016256 dimer interface [polypeptide binding]; other site 101510016257 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 101510016258 Mrr N-terminal domain; Region: Mrr_N; pfam14338 101510016259 Restriction endonuclease; Region: Mrr_cat; pfam04471 101510016260 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510016261 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510016262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 101510016263 active site 101510016264 phosphorylation site [posttranslational modification] 101510016265 intermolecular recognition site; other site 101510016266 dimerization interface [polypeptide binding]; other site 101510016267 NADH dehydrogenase subunit A; Validated; Region: PRK07928 101510016268 NADH dehydrogenase subunit B; Validated; Region: PRK06411 101510016269 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 101510016270 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 101510016271 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 101510016272 NADH dehydrogenase subunit D; Validated; Region: PRK06075 101510016273 NADH dehydrogenase subunit E; Validated; Region: PRK07539 101510016274 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 101510016275 putative dimer interface [polypeptide binding]; other site 101510016276 [2Fe-2S] cluster binding site [ion binding]; other site 101510016277 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 101510016278 SLBB domain; Region: SLBB; pfam10531 101510016279 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 101510016280 NADH dehydrogenase subunit G; Validated; Region: PRK07860 101510016281 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510016282 catalytic loop [active] 101510016283 iron binding site [ion binding]; other site 101510016284 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 101510016285 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 101510016286 molybdopterin cofactor binding site; other site 101510016287 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 101510016288 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 101510016289 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 101510016290 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 101510016291 4Fe-4S binding domain; Region: Fer4; pfam00037 101510016292 4Fe-4S binding domain; Region: Fer4; pfam00037 101510016293 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 101510016294 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 101510016295 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 101510016296 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 101510016297 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 101510016298 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 101510016299 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 101510016300 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 101510016301 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 101510016302 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 101510016303 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 101510016304 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510016305 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510016306 MarR family; Region: MarR_2; cl17246 101510016307 mannosyltransferase; Provisional; Region: pimE; PRK13375 101510016308 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 101510016309 aromatic arch; other site 101510016310 DCoH dimer interaction site [polypeptide binding]; other site 101510016311 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 101510016312 DCoH tetramer interaction site [polypeptide binding]; other site 101510016313 substrate binding site [chemical binding]; other site 101510016314 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 101510016315 active site 101510016316 8-oxo-dGMP binding site [chemical binding]; other site 101510016317 nudix motif; other site 101510016318 metal binding site [ion binding]; metal-binding site 101510016319 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 101510016320 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 101510016321 G1 box; other site 101510016322 putative GEF interaction site [polypeptide binding]; other site 101510016323 GTP/Mg2+ binding site [chemical binding]; other site 101510016324 Switch I region; other site 101510016325 G2 box; other site 101510016326 G3 box; other site 101510016327 Switch II region; other site 101510016328 G4 box; other site 101510016329 G5 box; other site 101510016330 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 101510016331 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 101510016332 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 101510016333 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 101510016334 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 101510016335 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 101510016336 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 101510016337 tetramer interface [polypeptide binding]; other site 101510016338 heme binding pocket [chemical binding]; other site 101510016339 NADPH binding site [chemical binding]; other site 101510016340 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510016341 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 101510016342 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 101510016343 active site 101510016344 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 101510016345 Fe-S cluster binding site [ion binding]; other site 101510016346 DNA binding site [nucleotide binding] 101510016347 active site 101510016348 Predicted membrane protein [Function unknown]; Region: COG3428 101510016349 Bacterial PH domain; Region: DUF304; pfam03703 101510016350 Uncharacterized conserved protein [Function unknown]; Region: COG3402 101510016351 FO synthase; Reviewed; Region: fbiC; PRK09234 101510016352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510016353 FeS/SAM binding site; other site 101510016354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510016355 FeS/SAM binding site; other site 101510016356 Ferredoxin [Energy production and conversion]; Region: COG1146 101510016357 4Fe-4S binding domain; Region: Fer4; pfam00037 101510016358 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 101510016359 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510016360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510016361 homodimer interface [polypeptide binding]; other site 101510016362 catalytic residue [active] 101510016363 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 101510016364 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 101510016365 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 101510016366 Glutamate binding site [chemical binding]; other site 101510016367 NAD binding site [chemical binding]; other site 101510016368 catalytic residues [active] 101510016369 Proline dehydrogenase; Region: Pro_dh; cl03282 101510016370 acyl-CoA synthetase; Validated; Region: PRK07787 101510016371 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510016372 acyl-activating enzyme (AAE) consensus motif; other site 101510016373 AMP binding site [chemical binding]; other site 101510016374 active site 101510016375 CoA binding site [chemical binding]; other site 101510016376 Prostaglandin dehydrogenases; Region: PGDH; cd05288 101510016377 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 101510016378 NAD(P) binding site [chemical binding]; other site 101510016379 substrate binding site [chemical binding]; other site 101510016380 dimer interface [polypeptide binding]; other site 101510016381 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510016382 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 101510016383 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 101510016384 metal ion-dependent adhesion site (MIDAS); other site 101510016385 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 101510016386 Sulfatase; Region: Sulfatase; pfam00884 101510016387 Sulfatase; Region: Sulfatase; cl17466 101510016388 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 101510016389 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 101510016390 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 101510016391 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510016392 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 101510016393 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 101510016394 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 101510016395 putative trimer interface [polypeptide binding]; other site 101510016396 putative CoA binding site [chemical binding]; other site 101510016397 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 101510016398 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 101510016399 metal binding site [ion binding]; metal-binding site 101510016400 putative dimer interface [polypeptide binding]; other site 101510016401 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 101510016402 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 101510016403 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 101510016404 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 101510016405 acyl-activating enzyme (AAE) consensus motif; other site 101510016406 putative AMP binding site [chemical binding]; other site 101510016407 putative active site [active] 101510016408 putative CoA binding site [chemical binding]; other site 101510016409 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 101510016410 dihydropteroate synthase; Region: DHPS; TIGR01496 101510016411 substrate binding pocket [chemical binding]; other site 101510016412 dimer interface [polypeptide binding]; other site 101510016413 inhibitor binding site; inhibition site 101510016414 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 101510016415 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 101510016416 DivIVA domain; Region: DivI1A_domain; TIGR03544 101510016417 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 101510016418 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 101510016419 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 101510016420 Methyltransferase domain; Region: Methyltransf_26; pfam13659 101510016421 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 101510016422 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510016423 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 101510016424 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 101510016425 ligand binding site; other site 101510016426 oligomer interface; other site 101510016427 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 101510016428 dimer interface [polypeptide binding]; other site 101510016429 N-terminal domain interface [polypeptide binding]; other site 101510016430 sulfate 1 binding site; other site 101510016431 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 101510016432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510016433 S-adenosylmethionine binding site [chemical binding]; other site 101510016434 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 101510016435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510016436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510016437 DNA binding residues [nucleotide binding] 101510016438 Putative zinc-finger; Region: zf-HC2; pfam13490 101510016439 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 101510016440 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 101510016441 protein binding site [polypeptide binding]; other site 101510016442 sec-independent translocase; Provisional; Region: PRK03100 101510016443 Domain of unknown function DUF59; Region: DUF59; cl00941 101510016444 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 101510016445 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 101510016446 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 101510016447 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 101510016448 N-acetyl-D-glucosamine binding site [chemical binding]; other site 101510016449 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 101510016450 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 101510016451 N-acetyl-D-glucosamine binding site [chemical binding]; other site 101510016452 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 101510016453 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 101510016454 PRC-barrel domain; Region: PRC; pfam05239 101510016455 MgtE intracellular N domain; Region: MgtE_N; smart00924 101510016456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 101510016457 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 101510016458 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 101510016459 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 101510016460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510016461 dimer interface [polypeptide binding]; other site 101510016462 conserved gate region; other site 101510016463 putative PBP binding loops; other site 101510016464 ABC-ATPase subunit interface; other site 101510016465 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 101510016466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510016467 dimer interface [polypeptide binding]; other site 101510016468 conserved gate region; other site 101510016469 putative PBP binding loops; other site 101510016470 ABC-ATPase subunit interface; other site 101510016471 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 101510016472 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 101510016473 Walker A/P-loop; other site 101510016474 ATP binding site [chemical binding]; other site 101510016475 Q-loop/lid; other site 101510016476 ABC transporter signature motif; other site 101510016477 Walker B; other site 101510016478 D-loop; other site 101510016479 H-loop/switch region; other site 101510016480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510016481 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 101510016482 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 101510016483 active site 101510016484 metal binding site [ion binding]; metal-binding site 101510016485 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 101510016486 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 101510016487 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 101510016488 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 101510016489 oligomer interface [polypeptide binding]; other site 101510016490 metal binding site [ion binding]; metal-binding site 101510016491 metal binding site [ion binding]; metal-binding site 101510016492 putative Cl binding site [ion binding]; other site 101510016493 basic sphincter; other site 101510016494 hydrophobic gate; other site 101510016495 periplasmic entrance; other site 101510016496 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 101510016497 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 101510016498 active site 101510016499 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 101510016500 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 101510016501 Malic enzyme, N-terminal domain; Region: malic; pfam00390 101510016502 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 101510016503 NAD(P) binding pocket [chemical binding]; other site 101510016504 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510016505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510016506 ABC-ATPase subunit interface; other site 101510016507 putative PBP binding loops; other site 101510016508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 101510016509 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510016510 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 101510016511 Walker A/P-loop; other site 101510016512 ATP binding site [chemical binding]; other site 101510016513 Q-loop/lid; other site 101510016514 ABC transporter signature motif; other site 101510016515 Walker B; other site 101510016516 D-loop; other site 101510016517 H-loop/switch region; other site 101510016518 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 101510016519 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 101510016520 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510016521 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510016522 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510016523 short chain dehydrogenase; Provisional; Region: PRK07832 101510016524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510016525 NAD(P) binding site [chemical binding]; other site 101510016526 active site 101510016527 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510016528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510016529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510016530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510016531 Predicted ATPase [General function prediction only]; Region: COG3910 101510016532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 101510016533 Walker A/P-loop; other site 101510016534 ATP binding site [chemical binding]; other site 101510016535 Q-loop/lid; other site 101510016536 ABC transporter signature motif; other site 101510016537 Walker B; other site 101510016538 D-loop; other site 101510016539 H-loop/switch region; other site 101510016540 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 101510016541 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 101510016542 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 101510016543 TPP-binding site [chemical binding]; other site 101510016544 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 101510016545 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 101510016546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510016547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510016548 Walker A/P-loop; other site 101510016549 ATP binding site [chemical binding]; other site 101510016550 Q-loop/lid; other site 101510016551 ABC transporter signature motif; other site 101510016552 Walker B; other site 101510016553 D-loop; other site 101510016554 H-loop/switch region; other site 101510016555 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 101510016556 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510016557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510016558 Walker A/P-loop; other site 101510016559 ATP binding site [chemical binding]; other site 101510016560 Q-loop/lid; other site 101510016561 ABC transporter signature motif; other site 101510016562 Walker B; other site 101510016563 D-loop; other site 101510016564 H-loop/switch region; other site 101510016565 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 101510016566 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 101510016567 Walker A/P-loop; other site 101510016568 ATP binding site [chemical binding]; other site 101510016569 Q-loop/lid; other site 101510016570 ABC transporter signature motif; other site 101510016571 Walker B; other site 101510016572 D-loop; other site 101510016573 H-loop/switch region; other site 101510016574 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510016575 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 101510016576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510016577 catalytic residue [active] 101510016578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510016579 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510016580 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 101510016581 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510016582 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 101510016583 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 101510016584 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 101510016585 putative dimer interface [polypeptide binding]; other site 101510016586 N-terminal domain interface [polypeptide binding]; other site 101510016587 putative substrate binding pocket (H-site) [chemical binding]; other site 101510016588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 101510016589 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510016590 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 101510016591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510016592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510016593 putative substrate translocation pore; other site 101510016594 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510016595 FAD binding domain; Region: FAD_binding_4; pfam01565 101510016596 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510016597 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510016598 substrate binding site [chemical binding]; other site 101510016599 oxyanion hole (OAH) forming residues; other site 101510016600 trimer interface [polypeptide binding]; other site 101510016601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510016602 AMP-binding enzyme; Region: AMP-binding; pfam00501 101510016603 acyl-activating enzyme (AAE) consensus motif; other site 101510016604 active site 101510016605 AMP binding site [chemical binding]; other site 101510016606 CoA binding site [chemical binding]; other site 101510016607 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 101510016608 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 101510016609 active site 101510016610 purine riboside binding site [chemical binding]; other site 101510016611 Amidase; Region: Amidase; cl11426 101510016612 indole-3-acetamide amidohydrolase; Region: PLN02722 101510016613 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 101510016614 FAD binding domain; Region: FAD_binding_4; pfam01565 101510016615 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 101510016616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510016617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510016618 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 101510016619 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 101510016620 dimer interface [polypeptide binding]; other site 101510016621 active site 101510016622 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 101510016623 substrate binding site [chemical binding]; other site 101510016624 catalytic residue [active] 101510016625 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 101510016626 RNase_H superfamily; Region: RNase_H_2; pfam13482 101510016627 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 101510016628 AAA domain; Region: AAA_30; pfam13604 101510016629 AAA domain; Region: AAA_12; pfam13087 101510016630 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510016631 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510016632 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 101510016633 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 101510016634 acyl-activating enzyme (AAE) consensus motif; other site 101510016635 putative AMP binding site [chemical binding]; other site 101510016636 putative active site [active] 101510016637 putative CoA binding site [chemical binding]; other site 101510016638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510016639 active site 101510016640 Predicted amidohydrolase [General function prediction only]; Region: COG0388 101510016641 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 101510016642 putative active site [active] 101510016643 catalytic triad [active] 101510016644 putative dimer interface [polypeptide binding]; other site 101510016645 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 101510016646 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 101510016647 ATP binding site [chemical binding]; other site 101510016648 Mg++ binding site [ion binding]; other site 101510016649 motif III; other site 101510016650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510016651 nucleotide binding region [chemical binding]; other site 101510016652 ATP-binding site [chemical binding]; other site 101510016653 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 101510016654 putative RNA binding site [nucleotide binding]; other site 101510016655 Protein of unknown function (DUF664); Region: DUF664; pfam04978 101510016656 trehalose synthase; Region: treS_nterm; TIGR02456 101510016657 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 101510016658 active site 101510016659 catalytic site [active] 101510016660 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 101510016661 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 101510016662 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 101510016663 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 101510016664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510016665 Walker A/P-loop; other site 101510016666 ATP binding site [chemical binding]; other site 101510016667 Q-loop/lid; other site 101510016668 ABC transporter signature motif; other site 101510016669 Walker B; other site 101510016670 D-loop; other site 101510016671 H-loop/switch region; other site 101510016672 hypothetical protein; Provisional; Region: PRK04233 101510016673 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510016674 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510016675 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510016676 acyl-activating enzyme (AAE) consensus motif; other site 101510016677 acyl-activating enzyme (AAE) consensus motif; other site 101510016678 putative AMP binding site [chemical binding]; other site 101510016679 putative active site [active] 101510016680 putative CoA binding site [chemical binding]; other site 101510016681 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510016682 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510016683 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 101510016684 Walker A/P-loop; other site 101510016685 ATP binding site [chemical binding]; other site 101510016686 Q-loop/lid; other site 101510016687 ABC transporter signature motif; other site 101510016688 Walker B; other site 101510016689 D-loop; other site 101510016690 H-loop/switch region; other site 101510016691 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 101510016692 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 101510016693 FtsX-like permease family; Region: FtsX; pfam02687 101510016694 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 101510016695 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 101510016696 FtsX-like permease family; Region: FtsX; pfam02687 101510016697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 101510016698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510016699 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 101510016700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510016701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510016702 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 101510016703 A new structural DNA glycosylase; Region: AlkD_like; cd06561 101510016704 active site 101510016705 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 101510016706 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 101510016707 FAD binding pocket [chemical binding]; other site 101510016708 FAD binding motif [chemical binding]; other site 101510016709 phosphate binding motif [ion binding]; other site 101510016710 beta-alpha-beta structure motif; other site 101510016711 NAD(p) ribose binding residues [chemical binding]; other site 101510016712 NAD binding pocket [chemical binding]; other site 101510016713 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 101510016714 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510016715 catalytic loop [active] 101510016716 iron binding site [ion binding]; other site 101510016717 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 101510016718 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 101510016719 dimer interface [polypeptide binding]; other site 101510016720 active site 101510016721 metal binding site [ion binding]; metal-binding site 101510016722 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 101510016723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510016724 Walker A motif; other site 101510016725 ATP binding site [chemical binding]; other site 101510016726 Walker B motif; other site 101510016727 arginine finger; other site 101510016728 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 101510016729 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 101510016730 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 101510016731 putative active site [active] 101510016732 metal binding site [ion binding]; metal-binding site 101510016733 GAF domain; Region: GAF_3; pfam13492 101510016734 GAF domain; Region: GAF_2; pfam13185 101510016735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510016736 Histidine kinase; Region: HisKA_3; pfam07730 101510016737 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 101510016738 ATP binding site [chemical binding]; other site 101510016739 Mg2+ binding site [ion binding]; other site 101510016740 G-X-G motif; other site 101510016741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510016742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510016743 active site 101510016744 phosphorylation site [posttranslational modification] 101510016745 intermolecular recognition site; other site 101510016746 dimerization interface [polypeptide binding]; other site 101510016747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510016748 DNA binding residues [nucleotide binding] 101510016749 dimerization interface [polypeptide binding]; other site 101510016750 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 101510016751 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 101510016752 Walker A/P-loop; other site 101510016753 ATP binding site [chemical binding]; other site 101510016754 Q-loop/lid; other site 101510016755 ABC transporter signature motif; other site 101510016756 Walker B; other site 101510016757 D-loop; other site 101510016758 H-loop/switch region; other site 101510016759 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 101510016760 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 101510016761 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 101510016762 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 101510016763 Domain of unknown function (DUF222); Region: DUF222; pfam02720 101510016764 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 101510016765 active site 101510016766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510016767 S-adenosylmethionine binding site [chemical binding]; other site 101510016768 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 101510016769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510016770 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 101510016771 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 101510016772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510016773 FeS/SAM binding site; other site 101510016774 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 101510016775 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510016776 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 101510016777 phosphate binding site [ion binding]; other site 101510016778 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996 101510016779 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510016780 phosphate binding site [ion binding]; other site 101510016781 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510016782 classical (c) SDRs; Region: SDR_c; cd05233 101510016783 NAD(P) binding site [chemical binding]; other site 101510016784 active site 101510016785 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 101510016786 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510016787 phosphate binding site [ion binding]; other site 101510016788 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 101510016789 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 101510016790 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 101510016791 Probable Catalytic site; other site 101510016792 metal-binding site 101510016793 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 101510016794 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510016795 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 101510016796 DNA binding site [nucleotide binding] 101510016797 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 101510016798 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510016799 NAD(P) binding site [chemical binding]; other site 101510016800 catalytic residues [active] 101510016801 Protein of unknown function (DUF779); Region: DUF779; pfam05610 101510016802 ethanolamine permease; Region: 2A0305; TIGR00908 101510016803 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 101510016804 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 101510016805 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 101510016806 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510016807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510016808 putative substrate translocation pore; other site 101510016809 AMP-binding domain protein; Validated; Region: PRK08315 101510016810 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510016811 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 101510016812 acyl-activating enzyme (AAE) consensus motif; other site 101510016813 putative AMP binding site [chemical binding]; other site 101510016814 putative active site [active] 101510016815 putative CoA binding site [chemical binding]; other site 101510016816 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 101510016817 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 101510016818 Domain of unknown function (DUF336); Region: DUF336; cl01249 101510016819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 101510016820 Histidine kinase; Region: HisKA_3; pfam07730 101510016821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510016822 ATP binding site [chemical binding]; other site 101510016823 Mg2+ binding site [ion binding]; other site 101510016824 G-X-G motif; other site 101510016825 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510016826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510016827 active site 101510016828 phosphorylation site [posttranslational modification] 101510016829 intermolecular recognition site; other site 101510016830 dimerization interface [polypeptide binding]; other site 101510016831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510016832 DNA binding residues [nucleotide binding] 101510016833 dimerization interface [polypeptide binding]; other site 101510016834 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 101510016835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510016836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510016837 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510016838 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 101510016839 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510016840 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 101510016841 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510016842 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 101510016843 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 101510016844 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510016845 carboxyltransferase (CT) interaction site; other site 101510016846 biotinylation site [posttranslational modification]; other site 101510016847 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510016848 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510016849 active site 101510016850 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 101510016851 putative active site [active] 101510016852 putative catalytic site [active] 101510016853 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 101510016854 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 101510016855 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 101510016856 acyl-activating enzyme (AAE) consensus motif; other site 101510016857 putative AMP binding site [chemical binding]; other site 101510016858 putative active site [active] 101510016859 putative CoA binding site [chemical binding]; other site 101510016860 Condensation domain; Region: Condensation; pfam00668 101510016861 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016862 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510016863 acyl-activating enzyme (AAE) consensus motif; other site 101510016864 AMP binding site [chemical binding]; other site 101510016865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510016866 Condensation domain; Region: Condensation; pfam00668 101510016867 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510016868 Condensation domain; Region: Condensation; pfam00668 101510016869 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016870 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510016871 acyl-activating enzyme (AAE) consensus motif; other site 101510016872 AMP binding site [chemical binding]; other site 101510016873 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 101510016874 Condensation domain; Region: Condensation; pfam00668 101510016875 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510016876 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510016877 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016878 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510016879 acyl-activating enzyme (AAE) consensus motif; other site 101510016880 AMP binding site [chemical binding]; other site 101510016881 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510016882 Condensation domain; Region: Condensation; pfam00668 101510016883 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510016884 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510016885 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016886 acyl-activating enzyme (AAE) consensus motif; other site 101510016887 AMP binding site [chemical binding]; other site 101510016888 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510016889 Condensation domain; Region: Condensation; pfam00668 101510016890 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510016891 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510016892 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510016893 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016894 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510016895 acyl-activating enzyme (AAE) consensus motif; other site 101510016896 AMP binding site [chemical binding]; other site 101510016897 Condensation domain; Region: Condensation; pfam00668 101510016898 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510016899 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510016900 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016901 acyl-activating enzyme (AAE) consensus motif; other site 101510016902 AMP binding site [chemical binding]; other site 101510016903 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510016904 peptide synthase; Provisional; Region: PRK12467 101510016905 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510016906 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016907 acyl-activating enzyme (AAE) consensus motif; other site 101510016908 AMP binding site [chemical binding]; other site 101510016909 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510016910 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510016911 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016912 acyl-activating enzyme (AAE) consensus motif; other site 101510016913 AMP binding site [chemical binding]; other site 101510016914 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510016915 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510016916 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510016917 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510016918 acyl-activating enzyme (AAE) consensus motif; other site 101510016919 AMP binding site [chemical binding]; other site 101510016920 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510016921 Condensation domain; Region: Condensation; pfam00668 101510016922 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510016923 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 101510016924 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 101510016925 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 101510016926 NAD(P) binding pocket [chemical binding]; other site 101510016927 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 101510016928 Glutamine amidotransferase class-I; Region: GATase; pfam00117 101510016929 glutamine binding [chemical binding]; other site 101510016930 catalytic triad [active] 101510016931 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 101510016932 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 101510016933 chorismate binding enzyme; Region: Chorismate_bind; cl10555 101510016934 Chorismate mutase type II; Region: CM_2; cl00693 101510016935 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 101510016936 Lipase (class 2); Region: Lipase_2; pfam01674 101510016937 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510016938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510016939 DNA-binding site [nucleotide binding]; DNA binding site 101510016940 FCD domain; Region: FCD; pfam07729 101510016941 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510016942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510016943 active site 101510016944 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510016945 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 101510016946 NAD(P) binding site [chemical binding]; other site 101510016947 catalytic residues [active] 101510016948 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 101510016949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510016950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510016951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510016952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510016953 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 101510016954 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510016955 dimer interface [polypeptide binding]; other site 101510016956 active site 101510016957 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 101510016958 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510016959 substrate binding site [chemical binding]; other site 101510016960 oxyanion hole (OAH) forming residues; other site 101510016961 trimer interface [polypeptide binding]; other site 101510016962 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510016963 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510016964 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 101510016965 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510016966 FMN binding site [chemical binding]; other site 101510016967 substrate binding site [chemical binding]; other site 101510016968 putative catalytic residue [active] 101510016969 enoyl-CoA hydratase; Provisional; Region: PRK06688 101510016970 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510016971 substrate binding site [chemical binding]; other site 101510016972 oxyanion hole (OAH) forming residues; other site 101510016973 trimer interface [polypeptide binding]; other site 101510016974 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 101510016975 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510016976 acyl-activating enzyme (AAE) consensus motif; other site 101510016977 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510016978 acyl-activating enzyme (AAE) consensus motif; other site 101510016979 putative AMP binding site [chemical binding]; other site 101510016980 putative active site [active] 101510016981 putative CoA binding site [chemical binding]; other site 101510016982 Permease; Region: Permease; pfam02405 101510016983 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 101510016984 Permease; Region: Permease; pfam02405 101510016985 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 101510016986 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510016987 mce related protein; Region: MCE; pfam02470 101510016988 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510016989 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 101510016990 mce related protein; Region: MCE; pfam02470 101510016991 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510016992 mce related protein; Region: MCE; pfam02470 101510016993 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510016994 mce related protein; Region: MCE; pfam02470 101510016995 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510016996 mce related protein; Region: MCE; pfam02470 101510016997 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510016998 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510016999 mce related protein; Region: MCE; pfam02470 101510017000 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510017001 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510017002 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510017003 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 101510017004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510017005 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 101510017006 Walker A/P-loop; other site 101510017007 ATP binding site [chemical binding]; other site 101510017008 Q-loop/lid; other site 101510017009 ABC transporter signature motif; other site 101510017010 Walker B; other site 101510017011 D-loop; other site 101510017012 H-loop/switch region; other site 101510017013 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510017014 CoenzymeA binding site [chemical binding]; other site 101510017015 subunit interaction site [polypeptide binding]; other site 101510017016 PHB binding site; other site 101510017017 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 101510017018 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 101510017019 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 101510017020 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 101510017021 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 101510017022 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 101510017023 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 101510017024 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 101510017025 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 101510017026 putative translocon binding site; other site 101510017027 protein-rRNA interface [nucleotide binding]; other site 101510017028 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 101510017029 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 101510017030 G-X-X-G motif; other site 101510017031 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 101510017032 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 101510017033 23S rRNA interface [nucleotide binding]; other site 101510017034 5S rRNA interface [nucleotide binding]; other site 101510017035 putative antibiotic binding site [chemical binding]; other site 101510017036 L25 interface [polypeptide binding]; other site 101510017037 L27 interface [polypeptide binding]; other site 101510017038 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 101510017039 putative translocon interaction site; other site 101510017040 signal recognition particle (SRP54) interaction site; other site 101510017041 L23 interface [polypeptide binding]; other site 101510017042 trigger factor interaction site; other site 101510017043 23S rRNA interface [nucleotide binding]; other site 101510017044 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 101510017045 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 101510017046 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 101510017047 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 101510017048 RNA binding site [nucleotide binding]; other site 101510017049 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 101510017050 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 101510017051 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 101510017052 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 101510017053 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 101510017054 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 101510017055 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 101510017056 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 101510017057 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 101510017058 5S rRNA interface [nucleotide binding]; other site 101510017059 L27 interface [polypeptide binding]; other site 101510017060 23S rRNA interface [nucleotide binding]; other site 101510017061 L5 interface [polypeptide binding]; other site 101510017062 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 101510017063 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 101510017064 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 101510017065 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 101510017066 23S rRNA binding site [nucleotide binding]; other site 101510017067 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 101510017068 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 101510017069 SecY translocase; Region: SecY; pfam00344 101510017070 adenylate kinase; Reviewed; Region: adk; PRK00279 101510017071 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 101510017072 AMP-binding site [chemical binding]; other site 101510017073 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 101510017074 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 101510017075 active site 101510017076 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 101510017077 putative active site [active] 101510017078 dimerization interface [polypeptide binding]; other site 101510017079 putative tRNAtyr binding site [nucleotide binding]; other site 101510017080 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 101510017081 rRNA binding site [nucleotide binding]; other site 101510017082 predicted 30S ribosome binding site; other site 101510017083 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 101510017084 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 101510017085 30S ribosomal protein S13; Region: bact_S13; TIGR03631 101510017086 30S ribosomal protein S11; Validated; Region: PRK05309 101510017087 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 101510017088 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 101510017089 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 101510017090 RNA binding surface [nucleotide binding]; other site 101510017091 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 101510017092 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 101510017093 alphaNTD - beta interaction site [polypeptide binding]; other site 101510017094 alphaNTD homodimer interface [polypeptide binding]; other site 101510017095 alphaNTD - beta' interaction site [polypeptide binding]; other site 101510017096 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 101510017097 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 101510017098 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 101510017099 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 101510017100 dimerization interface 3.5A [polypeptide binding]; other site 101510017101 active site 101510017102 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 101510017103 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 101510017104 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 101510017105 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 101510017106 AsnC family; Region: AsnC_trans_reg; pfam01037 101510017107 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 101510017108 Amidinotransferase; Region: Amidinotransf; cl12043 101510017109 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 101510017110 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510017111 inhibitor-cofactor binding pocket; inhibition site 101510017112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510017113 catalytic residue [active] 101510017114 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 101510017115 23S rRNA interface [nucleotide binding]; other site 101510017116 L3 interface [polypeptide binding]; other site 101510017117 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 101510017118 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 101510017119 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 101510017120 active site 101510017121 substrate binding site [chemical binding]; other site 101510017122 metal binding site [ion binding]; metal-binding site 101510017123 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510017124 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 101510017125 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 101510017126 glutaminase active site [active] 101510017127 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 101510017128 dimer interface [polypeptide binding]; other site 101510017129 active site 101510017130 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 101510017131 dimer interface [polypeptide binding]; other site 101510017132 active site 101510017133 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 101510017134 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 101510017135 Uncharacterized conserved protein [Function unknown]; Region: COG0062 101510017136 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 101510017137 putative substrate binding site [chemical binding]; other site 101510017138 putative ATP binding site [chemical binding]; other site 101510017139 alanine racemase; Reviewed; Region: alr; PRK00053 101510017140 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 101510017141 active site 101510017142 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 101510017143 dimer interface [polypeptide binding]; other site 101510017144 substrate binding site [chemical binding]; other site 101510017145 catalytic residues [active] 101510017146 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510017147 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510017148 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510017149 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 101510017150 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 101510017151 Glycoprotease family; Region: Peptidase_M22; pfam00814 101510017152 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 101510017153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510017154 Coenzyme A binding pocket [chemical binding]; other site 101510017155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 101510017156 UGMP family protein; Validated; Region: PRK09604 101510017157 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 101510017158 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510017159 nucleotide binding site [chemical binding]; other site 101510017160 Ion channel; Region: Ion_trans_2; pfam07885 101510017161 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 101510017162 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 101510017163 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 101510017164 oligomerisation interface [polypeptide binding]; other site 101510017165 mobile loop; other site 101510017166 roof hairpin; other site 101510017167 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 101510017168 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 101510017169 ring oligomerisation interface [polypeptide binding]; other site 101510017170 ATP/Mg binding site [chemical binding]; other site 101510017171 stacking interactions; other site 101510017172 hinge regions; other site 101510017173 Anti-sigma-K factor rskA; Region: RskA; pfam10099 101510017174 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 101510017175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510017176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510017177 DNA binding residues [nucleotide binding] 101510017178 Transcription factor WhiB; Region: Whib; pfam02467 101510017179 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510017180 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 101510017181 DNA binding residues [nucleotide binding] 101510017182 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 101510017183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510017184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510017185 DNA binding residues [nucleotide binding] 101510017186 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 101510017187 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510017188 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 101510017189 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 101510017190 active site 101510017191 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 101510017192 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510017193 phosphate binding site [ion binding]; other site 101510017194 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 101510017195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510017196 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510017197 GMP synthase; Reviewed; Region: guaA; PRK00074 101510017198 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 101510017199 AMP/PPi binding site [chemical binding]; other site 101510017200 candidate oxyanion hole; other site 101510017201 catalytic triad [active] 101510017202 potential glutamine specificity residues [chemical binding]; other site 101510017203 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 101510017204 ATP Binding subdomain [chemical binding]; other site 101510017205 Ligand Binding sites [chemical binding]; other site 101510017206 Dimerization subdomain; other site 101510017207 PspC domain; Region: PspC; pfam04024 101510017208 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 101510017209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510017210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510017211 ATP binding site [chemical binding]; other site 101510017212 Mg2+ binding site [ion binding]; other site 101510017213 G-X-G motif; other site 101510017214 Proteins of 100 residues with WXG; Region: WXG100; cl02005 101510017215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510017216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510017217 active site 101510017218 phosphorylation site [posttranslational modification] 101510017219 intermolecular recognition site; other site 101510017220 dimerization interface [polypeptide binding]; other site 101510017221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510017222 DNA binding residues [nucleotide binding] 101510017223 dimerization interface [polypeptide binding]; other site 101510017224 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510017225 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510017226 active site 101510017227 ATP binding site [chemical binding]; other site 101510017228 substrate binding site [chemical binding]; other site 101510017229 activation loop (A-loop); other site 101510017230 DNA Polymerase Y-family; Region: PolY_like; cd03468 101510017231 active site 101510017232 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 101510017233 DNA binding site [nucleotide binding] 101510017234 RibD C-terminal domain; Region: RibD_C; cl17279 101510017235 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 101510017236 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 101510017237 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510017238 metal binding site [ion binding]; metal-binding site 101510017239 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 101510017240 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510017241 nucleophilic elbow; other site 101510017242 catalytic triad; other site 101510017243 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 101510017244 active site 101510017245 diiron metal binding site [ion binding]; other site 101510017246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 101510017247 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 101510017248 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 101510017249 putative dimer interface [polypeptide binding]; other site 101510017250 putative [2Fe-2S] cluster binding site [ion binding]; other site 101510017251 short chain dehydrogenase; Provisional; Region: PRK07201 101510017252 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 101510017253 putative NAD(P) binding site [chemical binding]; other site 101510017254 active site 101510017255 putative substrate binding site [chemical binding]; other site 101510017256 classical (c) SDRs; Region: SDR_c; cd05233 101510017257 NAD(P) binding site [chemical binding]; other site 101510017258 active site 101510017259 MMPL family; Region: MMPL; pfam03176 101510017260 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 101510017261 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 101510017262 putative ligand binding residues [chemical binding]; other site 101510017263 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 101510017264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 101510017265 dimer interface [polypeptide binding]; other site 101510017266 putative PBP binding regions; other site 101510017267 ABC-ATPase subunit interface; other site 101510017268 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 101510017269 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 101510017270 Walker A/P-loop; other site 101510017271 ATP binding site [chemical binding]; other site 101510017272 Q-loop/lid; other site 101510017273 ABC transporter signature motif; other site 101510017274 Walker B; other site 101510017275 D-loop; other site 101510017276 H-loop/switch region; other site 101510017277 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 101510017278 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 101510017279 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 101510017280 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 101510017281 active site 101510017282 PHP Thumb interface [polypeptide binding]; other site 101510017283 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 101510017284 generic binding surface II; other site 101510017285 generic binding surface I; other site 101510017286 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 101510017287 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510017288 active site residue [active] 101510017289 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 101510017290 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 101510017291 gating phenylalanine in ion channel; other site 101510017292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510017293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510017294 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 101510017295 putative dimerization interface [polypeptide binding]; other site 101510017296 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 101510017297 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 101510017298 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 101510017299 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 101510017300 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 101510017301 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 101510017302 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 101510017303 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 101510017304 homodimer interface [polypeptide binding]; other site 101510017305 NADP binding site [chemical binding]; other site 101510017306 substrate binding site [chemical binding]; other site 101510017307 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 101510017308 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 101510017309 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 101510017310 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 101510017311 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 101510017312 homodimer interface [polypeptide binding]; other site 101510017313 substrate-cofactor binding pocket; other site 101510017314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510017315 catalytic residue [active] 101510017316 isocitrate dehydrogenase; Validated; Region: PRK08299 101510017317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510017318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510017319 putative substrate translocation pore; other site 101510017320 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 101510017321 putative active site [active] 101510017322 putative catalytic site [active] 101510017323 putative DNA binding site [nucleotide binding]; other site 101510017324 putative phosphate binding site [ion binding]; other site 101510017325 metal binding site A [ion binding]; metal-binding site 101510017326 putative AP binding site [nucleotide binding]; other site 101510017327 putative metal binding site B [ion binding]; other site 101510017328 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 101510017329 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 101510017330 active site 101510017331 HIGH motif; other site 101510017332 dimer interface [polypeptide binding]; other site 101510017333 KMSKS motif; other site 101510017334 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 101510017335 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 101510017336 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 101510017337 malate dehydrogenase; Provisional; Region: PRK05442 101510017338 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 101510017339 NAD(P) binding site [chemical binding]; other site 101510017340 dimer interface [polypeptide binding]; other site 101510017341 malate binding site [chemical binding]; other site 101510017342 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 101510017343 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 101510017344 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 101510017345 L-aspartate oxidase; Provisional; Region: PRK06175 101510017346 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 101510017347 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 101510017348 putative Iron-sulfur protein interface [polypeptide binding]; other site 101510017349 putative proximal heme binding site [chemical binding]; other site 101510017350 putative SdhC-like subunit interface [polypeptide binding]; other site 101510017351 putative distal heme binding site [chemical binding]; other site 101510017352 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 101510017353 putative Iron-sulfur protein interface [polypeptide binding]; other site 101510017354 putative proximal heme binding site [chemical binding]; other site 101510017355 putative SdhD-like interface [polypeptide binding]; other site 101510017356 putative distal heme binding site [chemical binding]; other site 101510017357 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 101510017358 active site 101510017359 catalytic motif [active] 101510017360 Zn binding site [ion binding]; other site 101510017361 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 101510017362 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 101510017363 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 101510017364 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 101510017365 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 101510017366 adenosine deaminase; Provisional; Region: PRK09358 101510017367 active site 101510017368 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510017369 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510017370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510017371 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 101510017372 Probable transposase; Region: OrfB_IS605; pfam01385 101510017373 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 101510017374 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510017375 active site 101510017376 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 101510017377 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 101510017378 active site 101510017379 substrate binding site [chemical binding]; other site 101510017380 metal binding site [ion binding]; metal-binding site 101510017381 purine nucleoside phosphorylase; Provisional; Region: PRK08202 101510017382 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510017383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510017384 substrate binding site [chemical binding]; other site 101510017385 oxyanion hole (OAH) forming residues; other site 101510017386 trimer interface [polypeptide binding]; other site 101510017387 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 101510017388 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 101510017389 metal binding site [ion binding]; metal-binding site 101510017390 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 101510017391 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 101510017392 metal binding site [ion binding]; metal-binding site 101510017393 putative dimer interface [polypeptide binding]; other site 101510017394 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 101510017395 putative active site pocket [active] 101510017396 dimerization interface [polypeptide binding]; other site 101510017397 putative catalytic residue [active] 101510017398 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 101510017399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510017400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510017401 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 101510017402 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 101510017403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510017404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510017405 homodimer interface [polypeptide binding]; other site 101510017406 catalytic residue [active] 101510017407 glycerol kinase; Provisional; Region: glpK; PRK00047 101510017408 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 101510017409 N- and C-terminal domain interface [polypeptide binding]; other site 101510017410 active site 101510017411 MgATP binding site [chemical binding]; other site 101510017412 catalytic site [active] 101510017413 metal binding site [ion binding]; metal-binding site 101510017414 putative homotetramer interface [polypeptide binding]; other site 101510017415 glycerol binding site [chemical binding]; other site 101510017416 homodimer interface [polypeptide binding]; other site 101510017417 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 101510017418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 101510017419 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 101510017420 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 101510017421 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 101510017422 putative DNA binding site [nucleotide binding]; other site 101510017423 catalytic residue [active] 101510017424 putative H2TH interface [polypeptide binding]; other site 101510017425 putative catalytic residues [active] 101510017426 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 101510017427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510017428 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 101510017429 ATP binding site [chemical binding]; other site 101510017430 putative Mg++ binding site [ion binding]; other site 101510017431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510017432 nucleotide binding region [chemical binding]; other site 101510017433 ATP-binding site [chemical binding]; other site 101510017434 DEAD/H associated; Region: DEAD_assoc; pfam08494 101510017435 Domain of unknown function (DUF222); Region: DUF222; pfam02720 101510017436 Domain of unknown function (DUF222); Region: DUF222; pfam02720 101510017437 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510017438 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510017439 active site 101510017440 aldehyde dehydrogenase family 7 member; Region: PLN02315 101510017441 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 101510017442 tetrameric interface [polypeptide binding]; other site 101510017443 NAD binding site [chemical binding]; other site 101510017444 catalytic residues [active] 101510017445 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 101510017446 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 101510017447 AsnC family; Region: AsnC_trans_reg; pfam01037 101510017448 L-lysine aminotransferase; Provisional; Region: PRK08297 101510017449 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510017450 inhibitor-cofactor binding pocket; inhibition site 101510017451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510017452 catalytic residue [active] 101510017453 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 101510017454 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 101510017455 VanZ like family; Region: VanZ; cl01971 101510017456 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 101510017457 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 101510017458 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 101510017459 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510017460 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 101510017461 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 101510017462 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510017463 carboxyltransferase (CT) interaction site; other site 101510017464 biotinylation site [posttranslational modification]; other site 101510017465 Condensation domain; Region: Condensation; pfam00668 101510017466 Fe-S metabolism associated domain; Region: SufE; cl00951 101510017467 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 101510017468 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 101510017469 active site residue [active] 101510017470 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 101510017471 active site residue [active] 101510017472 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 101510017473 heme-binding site [chemical binding]; other site 101510017474 Condensation domain; Region: Condensation; pfam00668 101510017475 peptide synthase; Provisional; Region: PRK12316 101510017476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510017477 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510017478 putative substrate translocation pore; other site 101510017479 Maf-like protein; Region: Maf; pfam02545 101510017480 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 101510017481 active site 101510017482 dimer interface [polypeptide binding]; other site 101510017483 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 101510017484 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 101510017485 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510017486 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510017487 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 101510017488 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 101510017489 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 101510017490 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 101510017491 Bacterial PH domain; Region: DUF304; pfam03703 101510017492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510017493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510017494 active site 101510017495 phosphorylation site [posttranslational modification] 101510017496 intermolecular recognition site; other site 101510017497 dimerization interface [polypeptide binding]; other site 101510017498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510017499 DNA binding site [nucleotide binding] 101510017500 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 101510017501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510017502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510017503 ATP binding site [chemical binding]; other site 101510017504 Mg2+ binding site [ion binding]; other site 101510017505 G-X-G motif; other site 101510017506 Predicted membrane protein [Function unknown]; Region: COG2246 101510017507 GtrA-like protein; Region: GtrA; pfam04138 101510017508 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 101510017509 ATP-grasp domain; Region: ATP-grasp; pfam02222 101510017510 AIR carboxylase; Region: AIRC; pfam00731 101510017511 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 101510017512 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 101510017513 putative active site [active] 101510017514 TIGR03089 family protein; Region: TIGR03089 101510017515 Transcriptional regulator [Transcription]; Region: LytR; COG1316 101510017516 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 101510017517 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 101510017518 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 101510017519 NADP binding site [chemical binding]; other site 101510017520 putative substrate binding site [chemical binding]; other site 101510017521 active site 101510017522 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 101510017523 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 101510017524 Probable Catalytic site; other site 101510017525 metal-binding site 101510017526 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 101510017527 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 101510017528 active site 101510017529 Substrate binding site; other site 101510017530 Mg++ binding site; other site 101510017531 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 101510017532 N-terminal domain interface [polypeptide binding]; other site 101510017533 sulfate 1 binding site; other site 101510017534 Transposase IS200 like; Region: Y1_Tnp; cl00848 101510017535 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 101510017536 nudix motif; other site 101510017537 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 101510017538 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 101510017539 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 101510017540 putative FMN binding site [chemical binding]; other site 101510017541 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 101510017542 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 101510017543 dimer interface [polypeptide binding]; other site 101510017544 phosphate binding site [ion binding]; other site 101510017545 Transcription factor WhiB; Region: Whib; pfam02467 101510017546 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 101510017547 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 101510017548 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 101510017549 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 101510017550 active site 101510017551 substrate binding site [chemical binding]; other site 101510017552 metal binding site [ion binding]; metal-binding site 101510017553 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 101510017554 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 101510017555 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 101510017556 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 101510017557 Cation efflux family; Region: Cation_efflux; pfam01545 101510017558 amino acid transporter; Region: 2A0306; TIGR00909 101510017559 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 101510017560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510017561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510017562 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 101510017563 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 101510017564 homotetramer interface [polypeptide binding]; other site 101510017565 ligand binding site [chemical binding]; other site 101510017566 catalytic site [active] 101510017567 NAD binding site [chemical binding]; other site 101510017568 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 101510017569 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 101510017570 TMP-binding site; other site 101510017571 ATP-binding site [chemical binding]; other site 101510017572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510017573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510017574 active site 101510017575 phosphorylation site [posttranslational modification] 101510017576 intermolecular recognition site; other site 101510017577 dimerization interface [polypeptide binding]; other site 101510017578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510017579 DNA binding site [nucleotide binding] 101510017580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510017581 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510017582 dimerization interface [polypeptide binding]; other site 101510017583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510017584 dimer interface [polypeptide binding]; other site 101510017585 phosphorylation site [posttranslational modification] 101510017586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510017587 ATP binding site [chemical binding]; other site 101510017588 Mg2+ binding site [ion binding]; other site 101510017589 G-X-G motif; other site 101510017590 lipoprotein LpqB; Provisional; Region: PRK13616 101510017591 Sporulation and spore germination; Region: Germane; pfam10646 101510017592 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 101510017593 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 101510017594 30S subunit binding site; other site 101510017595 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 101510017596 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 101510017597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 101510017598 nucleotide binding region [chemical binding]; other site 101510017599 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 101510017600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510017601 active site 101510017602 motif I; other site 101510017603 motif II; other site 101510017604 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510017605 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510017606 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 101510017607 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510017608 FAD binding pocket [chemical binding]; other site 101510017609 FAD binding motif [chemical binding]; other site 101510017610 phosphate binding motif [ion binding]; other site 101510017611 beta-alpha-beta structure motif; other site 101510017612 NAD binding pocket [chemical binding]; other site 101510017613 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510017614 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510017615 catalytic loop [active] 101510017616 iron binding site [ion binding]; other site 101510017617 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 101510017618 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 101510017619 putative di-iron ligands [ion binding]; other site 101510017620 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 101510017621 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 101510017622 putative di-iron ligands [ion binding]; other site 101510017623 Predicted GTPases [General function prediction only]; Region: COG1162 101510017624 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 101510017625 GTPase/Zn-binding domain interface [polypeptide binding]; other site 101510017626 GTP/Mg2+ binding site [chemical binding]; other site 101510017627 G4 box; other site 101510017628 G5 box; other site 101510017629 G1 box; other site 101510017630 Switch I region; other site 101510017631 G2 box; other site 101510017632 G3 box; other site 101510017633 Switch II region; other site 101510017634 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 101510017635 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 101510017636 hinge; other site 101510017637 active site 101510017638 Uncharacterized conserved protein [Function unknown]; Region: COG2135 101510017639 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 101510017640 putative deacylase active site [active] 101510017641 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 101510017642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510017643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510017644 DNA binding residues [nucleotide binding] 101510017645 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 101510017646 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510017647 carboxyltransferase (CT) interaction site; other site 101510017648 biotinylation site [posttranslational modification]; other site 101510017649 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 101510017650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 101510017651 putative active site [active] 101510017652 heme pocket [chemical binding]; other site 101510017653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 101510017654 Histidine kinase; Region: HisKA_2; pfam07568 101510017655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510017656 ATP binding site [chemical binding]; other site 101510017657 Mg2+ binding site [ion binding]; other site 101510017658 G-X-G motif; other site 101510017659 Transcription factor WhiB; Region: Whib; pfam02467 101510017660 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 101510017661 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 101510017662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 101510017663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510017664 Coenzyme A binding pocket [chemical binding]; other site 101510017665 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510017666 catalytic core [active] 101510017667 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510017668 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510017669 P-loop; other site 101510017670 Magnesium ion binding site [ion binding]; other site 101510017671 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510017672 Magnesium ion binding site [ion binding]; other site 101510017673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510017674 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 101510017675 NAD(P) binding site [chemical binding]; other site 101510017676 active site 101510017677 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 101510017678 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 101510017679 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 101510017680 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 101510017681 conserved cys residue [active] 101510017682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510017683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510017684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510017685 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 101510017686 active site 101510017687 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 101510017688 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 101510017689 ATP binding site [chemical binding]; other site 101510017690 Mg++ binding site [ion binding]; other site 101510017691 motif III; other site 101510017692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510017693 nucleotide binding region [chemical binding]; other site 101510017694 ATP-binding site [chemical binding]; other site 101510017695 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 101510017696 dinuclear metal binding motif [ion binding]; other site 101510017697 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 101510017698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510017699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510017700 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 101510017701 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 101510017702 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 101510017703 ATP binding site [chemical binding]; other site 101510017704 substrate interface [chemical binding]; other site 101510017705 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510017706 active site residue [active] 101510017707 TIGR02569 family protein; Region: TIGR02569_actnb 101510017708 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510017709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510017710 DNA-binding site [nucleotide binding]; DNA binding site 101510017711 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 101510017712 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 101510017713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510017714 putative substrate translocation pore; other site 101510017715 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 101510017716 nitrite reductase subunit NirD; Provisional; Region: PRK14989 101510017717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510017718 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 101510017719 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 101510017720 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 101510017721 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 101510017722 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 101510017723 active site 101510017724 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 101510017725 DNA binding site [nucleotide binding] 101510017726 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 101510017727 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 101510017728 putative active site [active] 101510017729 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 101510017730 putative active site [active] 101510017731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 101510017732 active site 101510017733 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 101510017734 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 101510017735 MPT binding site; other site 101510017736 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 101510017737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510017738 DNA-binding site [nucleotide binding]; DNA binding site 101510017739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510017740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510017741 homodimer interface [polypeptide binding]; other site 101510017742 catalytic residue [active] 101510017743 Secretory lipase; Region: LIP; pfam03583 101510017744 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 101510017745 active site 101510017746 DNA binding site [nucleotide binding] 101510017747 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510017748 Serine hydrolase; Region: Ser_hydrolase; cl17834 101510017749 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 101510017750 Part of AAA domain; Region: AAA_19; pfam13245 101510017751 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 101510017752 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 101510017753 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 101510017754 Part of AAA domain; Region: AAA_19; pfam13245 101510017755 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 101510017756 Predicted membrane protein [Function unknown]; Region: COG4270 101510017757 Ion channel; Region: Ion_trans_2; pfam07885 101510017758 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 101510017759 TrkA-N domain; Region: TrkA_N; pfam02254 101510017760 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 101510017761 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 101510017762 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 101510017763 putative NADH binding site [chemical binding]; other site 101510017764 putative active site [active] 101510017765 nudix motif; other site 101510017766 putative metal binding site [ion binding]; other site 101510017767 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 101510017768 catalytic residues [active] 101510017769 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 101510017770 Family description; Region: UvrD_C_2; pfam13538 101510017771 HRDC domain; Region: HRDC; pfam00570 101510017772 Transcription factor WhiB; Region: Whib; pfam02467 101510017773 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 101510017774 ABC1 family; Region: ABC1; pfam03109 101510017775 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 101510017776 active site 101510017777 ATP binding site [chemical binding]; other site 101510017778 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 101510017779 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 101510017780 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 101510017781 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 101510017782 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 101510017783 hypothetical protein; Provisional; Region: PRK12438 101510017784 hypothetical protein; Validated; Region: PRK00068 101510017785 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 101510017786 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 101510017787 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510017788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510017789 DNA-binding site [nucleotide binding]; DNA binding site 101510017790 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 101510017791 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 101510017792 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 101510017793 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 101510017794 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510017795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510017796 dimer interface [polypeptide binding]; other site 101510017797 conserved gate region; other site 101510017798 putative PBP binding loops; other site 101510017799 ABC-ATPase subunit interface; other site 101510017800 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510017801 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 101510017802 Walker A/P-loop; other site 101510017803 ATP binding site [chemical binding]; other site 101510017804 Q-loop/lid; other site 101510017805 ABC transporter signature motif; other site 101510017806 Walker B; other site 101510017807 D-loop; other site 101510017808 H-loop/switch region; other site 101510017809 acyl-CoA synthetase; Validated; Region: PRK07788 101510017810 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510017811 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510017812 acyl-activating enzyme (AAE) consensus motif; other site 101510017813 acyl-activating enzyme (AAE) consensus motif; other site 101510017814 AMP binding site [chemical binding]; other site 101510017815 active site 101510017816 CoA binding site [chemical binding]; other site 101510017817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510017818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510017819 active site 101510017820 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510017821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510017822 active site 101510017823 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 101510017824 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 101510017825 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 101510017826 active site 101510017827 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 101510017828 active site clefts [active] 101510017829 zinc binding site [ion binding]; other site 101510017830 dimer interface [polypeptide binding]; other site 101510017831 peptide chain release factor 2; Validated; Region: prfB; PRK00578 101510017832 This domain is found in peptide chain release factors; Region: PCRF; smart00937 101510017833 RF-1 domain; Region: RF-1; pfam00472 101510017834 Mechanosensitive ion channel; Region: MS_channel; pfam00924 101510017835 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 101510017836 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 101510017837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510017838 Walker A/P-loop; other site 101510017839 ATP binding site [chemical binding]; other site 101510017840 Q-loop/lid; other site 101510017841 ABC transporter signature motif; other site 101510017842 Walker B; other site 101510017843 D-loop; other site 101510017844 H-loop/switch region; other site 101510017845 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 101510017846 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 101510017847 SmpB-tmRNA interface; other site 101510017848 camphor resistance protein CrcB; Provisional; Region: PRK14211 101510017849 phosphoglucomutase; Validated; Region: PRK07564 101510017850 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 101510017851 active site 101510017852 substrate binding site [chemical binding]; other site 101510017853 metal binding site [ion binding]; metal-binding site 101510017854 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 101510017855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510017856 putative substrate translocation pore; other site 101510017857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510017858 putative substrate translocation pore; other site 101510017859 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 101510017860 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 101510017861 catalytic residues [active] 101510017862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 101510017863 PAS domain; Region: PAS_9; pfam13426 101510017864 putative active site [active] 101510017865 heme pocket [chemical binding]; other site 101510017866 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 101510017867 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 101510017868 trimer interface [polypeptide binding]; other site 101510017869 active site 101510017870 substrate binding site [chemical binding]; other site 101510017871 CoA binding site [chemical binding]; other site 101510017872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510017873 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 101510017874 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510017875 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 101510017876 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 101510017877 putative FMN binding site [chemical binding]; other site 101510017878 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 101510017879 DEAD-like helicases superfamily; Region: DEXDc; smart00487 101510017880 ATP binding site [chemical binding]; other site 101510017881 Mg++ binding site [ion binding]; other site 101510017882 motif III; other site 101510017883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510017884 nucleotide binding region [chemical binding]; other site 101510017885 ATP-binding site [chemical binding]; other site 101510017886 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 101510017887 MoaE homodimer interface [polypeptide binding]; other site 101510017888 MoaD interaction [polypeptide binding]; other site 101510017889 active site residues [active] 101510017890 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 101510017891 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 101510017892 trimer interface [polypeptide binding]; other site 101510017893 dimer interface [polypeptide binding]; other site 101510017894 putative active site [active] 101510017895 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 101510017896 MPT binding site; other site 101510017897 trimer interface [polypeptide binding]; other site 101510017898 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 101510017899 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 101510017900 dimer interface [polypeptide binding]; other site 101510017901 putative functional site; other site 101510017902 putative MPT binding site; other site 101510017903 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 101510017904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510017905 FeS/SAM binding site; other site 101510017906 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 101510017907 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 101510017908 MoaE interaction surface [polypeptide binding]; other site 101510017909 MoeB interaction surface [polypeptide binding]; other site 101510017910 thiocarboxylated glycine; other site 101510017911 NADH(P)-binding; Region: NAD_binding_10; pfam13460 101510017912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510017913 NAD(P) binding site [chemical binding]; other site 101510017914 active site 101510017915 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 101510017916 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 101510017917 homodimer interface [polypeptide binding]; other site 101510017918 NAD binding pocket [chemical binding]; other site 101510017919 ATP binding pocket [chemical binding]; other site 101510017920 Mg binding site [ion binding]; other site 101510017921 active-site loop [active] 101510017922 nucleosidase; Provisional; Region: PRK05634 101510017923 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 101510017924 META domain; Region: META; pfam03724 101510017925 META domain; Region: META; pfam03724 101510017926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510017927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510017928 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 101510017929 Predicted flavoprotein [General function prediction only]; Region: COG0431 101510017930 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 101510017931 FAD binding pocket [chemical binding]; other site 101510017932 FAD binding motif [chemical binding]; other site 101510017933 phosphate binding motif [ion binding]; other site 101510017934 NAD binding pocket [chemical binding]; other site 101510017935 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 101510017936 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 101510017937 catalytic residues [active] 101510017938 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 101510017939 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 101510017940 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 101510017941 Class I ribonucleotide reductase; Region: RNR_I; cd01679 101510017942 active site 101510017943 dimer interface [polypeptide binding]; other site 101510017944 catalytic residues [active] 101510017945 effector binding site; other site 101510017946 R2 peptide binding site; other site 101510017947 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 101510017948 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 101510017949 dimer interface [polypeptide binding]; other site 101510017950 putative radical transfer pathway; other site 101510017951 diiron center [ion binding]; other site 101510017952 tyrosyl radical; other site 101510017953 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 101510017954 nudix motif; other site 101510017955 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 101510017956 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 101510017957 siderophore binding site; other site 101510017958 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 101510017959 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 101510017960 siderophore binding site; other site 101510017961 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 101510017962 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 101510017963 D-pathway; other site 101510017964 Putative ubiquinol binding site [chemical binding]; other site 101510017965 Low-spin heme (heme b) binding site [chemical binding]; other site 101510017966 Putative water exit pathway; other site 101510017967 Binuclear center (heme o3/CuB) [ion binding]; other site 101510017968 K-pathway; other site 101510017969 Putative proton exit pathway; other site 101510017970 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 101510017971 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 101510017972 phosphoserine phosphatase SerB; Region: serB; TIGR00338 101510017973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510017974 motif II; other site 101510017975 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 101510017976 dimer interface [polypeptide binding]; other site 101510017977 putative active site [active] 101510017978 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 101510017979 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 101510017980 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 101510017981 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 101510017982 active site 101510017983 catalytic site [active] 101510017984 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 101510017985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510017986 Walker A/P-loop; other site 101510017987 ATP binding site [chemical binding]; other site 101510017988 ABC transporter signature motif; other site 101510017989 Walker B; other site 101510017990 D-loop; other site 101510017991 H-loop/switch region; other site 101510017992 enoyl-CoA hydratase; Provisional; Region: PRK05862 101510017993 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510017994 substrate binding site [chemical binding]; other site 101510017995 oxyanion hole (OAH) forming residues; other site 101510017996 trimer interface [polypeptide binding]; other site 101510017997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510017998 S-adenosylmethionine binding site [chemical binding]; other site 101510017999 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 101510018000 Trp docking motif [polypeptide binding]; other site 101510018001 active site 101510018002 PQQ-like domain; Region: PQQ_2; pfam13360 101510018003 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 101510018004 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 101510018005 trimer interface [polypeptide binding]; other site 101510018006 active site 101510018007 substrate binding site [chemical binding]; other site 101510018008 CoA binding site [chemical binding]; other site 101510018009 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 101510018010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510018011 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510018012 Uncharacterized conserved protein [Function unknown]; Region: COG1543 101510018013 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 101510018014 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 101510018015 Methyltransferase domain; Region: Methyltransf_31; pfam13847 101510018016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510018017 S-adenosylmethionine binding site [chemical binding]; other site 101510018018 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 101510018019 Ligand binding site [chemical binding]; other site 101510018020 Electron transfer flavoprotein domain; Region: ETF; pfam01012 101510018021 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 101510018022 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 101510018023 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 101510018024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 101510018025 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 101510018026 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 101510018027 putative acyl-acceptor binding pocket; other site 101510018028 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 101510018029 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 101510018030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510018031 catalytic residue [active] 101510018032 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 101510018033 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 101510018034 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 101510018035 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 101510018036 nucleotide binding pocket [chemical binding]; other site 101510018037 K-X-D-G motif; other site 101510018038 catalytic site [active] 101510018039 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 101510018040 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 101510018041 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 101510018042 Dimer interface [polypeptide binding]; other site 101510018043 BRCT sequence motif; other site 101510018044 putative acetyltransferase; Provisional; Region: PRK03624 101510018045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510018046 Coenzyme A binding pocket [chemical binding]; other site 101510018047 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 101510018048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 101510018049 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 101510018050 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 101510018051 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 101510018052 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 101510018053 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 101510018054 Histidine kinase; Region: HisKA_3; pfam07730 101510018055 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 101510018056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510018057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510018058 active site 101510018059 phosphorylation site [posttranslational modification] 101510018060 intermolecular recognition site; other site 101510018061 dimerization interface [polypeptide binding]; other site 101510018062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510018063 DNA binding residues [nucleotide binding] 101510018064 dimerization interface [polypeptide binding]; other site 101510018065 6-phosphofructokinase; Provisional; Region: PRK03202 101510018066 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 101510018067 active site 101510018068 ADP/pyrophosphate binding site [chemical binding]; other site 101510018069 dimerization interface [polypeptide binding]; other site 101510018070 allosteric effector site; other site 101510018071 fructose-1,6-bisphosphate binding site; other site 101510018072 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 101510018073 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 101510018074 GatB domain; Region: GatB_Yqey; smart00845 101510018075 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 101510018076 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 101510018077 Predicted membrane protein [Function unknown]; Region: COG2259 101510018078 amino acid transporter; Region: 2A0306; TIGR00909 101510018079 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 101510018080 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 101510018081 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 101510018082 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 101510018083 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 101510018084 PYR/PP interface [polypeptide binding]; other site 101510018085 dimer interface [polypeptide binding]; other site 101510018086 TPP binding site [chemical binding]; other site 101510018087 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510018088 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 101510018089 TPP-binding site [chemical binding]; other site 101510018090 dimer interface [polypeptide binding]; other site 101510018091 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 101510018092 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 101510018093 putative valine binding site [chemical binding]; other site 101510018094 dimer interface [polypeptide binding]; other site 101510018095 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 101510018096 ketol-acid reductoisomerase; Provisional; Region: PRK05479 101510018097 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 101510018098 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 101510018099 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 101510018100 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 101510018101 ligand binding site [chemical binding]; other site 101510018102 NAD binding site [chemical binding]; other site 101510018103 dimerization interface [polypeptide binding]; other site 101510018104 catalytic site [active] 101510018105 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 101510018106 putative L-serine binding site [chemical binding]; other site 101510018107 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 101510018108 tartrate dehydrogenase; Region: TTC; TIGR02089 101510018109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510018110 putative substrate translocation pore; other site 101510018111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510018112 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 101510018113 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510018114 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510018115 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 101510018116 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 101510018117 HIGH motif; other site 101510018118 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 101510018119 active site 101510018120 KMSKS motif; other site 101510018121 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 101510018122 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510018123 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510018124 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510018125 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 101510018126 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 101510018127 substrate binding site [chemical binding]; other site 101510018128 ligand binding site [chemical binding]; other site 101510018129 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 101510018130 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 101510018131 substrate binding site [chemical binding]; other site 101510018132 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 101510018133 IHF - DNA interface [nucleotide binding]; other site 101510018134 IHF dimer interface [polypeptide binding]; other site 101510018135 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 101510018136 active site 101510018137 Ap6A binding site [chemical binding]; other site 101510018138 nudix motif; other site 101510018139 metal binding site [ion binding]; metal-binding site 101510018140 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510018141 catalytic core [active] 101510018142 polyphosphate kinase; Provisional; Region: PRK05443 101510018143 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 101510018144 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 101510018145 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 101510018146 putative domain interface [polypeptide binding]; other site 101510018147 putative active site [active] 101510018148 catalytic site [active] 101510018149 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 101510018150 putative active site [active] 101510018151 catalytic site [active] 101510018152 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 101510018153 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 101510018154 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 101510018155 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 101510018156 cystathionine gamma-lyase; Validated; Region: PRK07582 101510018157 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510018158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510018159 catalytic residue [active] 101510018160 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 101510018161 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 101510018162 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 101510018163 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 101510018164 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 101510018165 thiamine monophosphate kinase; Provisional; Region: PRK05731 101510018166 ATP binding site [chemical binding]; other site 101510018167 dimerization interface [polypeptide binding]; other site 101510018168 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 101510018169 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 101510018170 trimer interface [polypeptide binding]; other site 101510018171 putative metal binding site [ion binding]; other site 101510018172 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 101510018173 ligand binding site [chemical binding]; other site 101510018174 active site 101510018175 UGI interface [polypeptide binding]; other site 101510018176 catalytic site [active] 101510018177 enoyl-CoA hydratase; Provisional; Region: PRK06688 101510018178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510018179 substrate binding site [chemical binding]; other site 101510018180 oxyanion hole (OAH) forming residues; other site 101510018181 trimer interface [polypeptide binding]; other site 101510018182 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 101510018183 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 101510018184 DAK2 domain; Region: Dak2; pfam02734 101510018185 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 101510018186 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 101510018187 generic binding surface II; other site 101510018188 ssDNA binding site; other site 101510018189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510018190 ATP binding site [chemical binding]; other site 101510018191 putative Mg++ binding site [ion binding]; other site 101510018192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510018193 nucleotide binding region [chemical binding]; other site 101510018194 ATP-binding site [chemical binding]; other site 101510018195 pyruvate carboxylase; Reviewed; Region: PRK12999 101510018196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510018197 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510018198 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 101510018199 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 101510018200 active site 101510018201 catalytic residues [active] 101510018202 metal binding site [ion binding]; metal-binding site 101510018203 homodimer binding site [polypeptide binding]; other site 101510018204 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510018205 carboxyltransferase (CT) interaction site; other site 101510018206 biotinylation site [posttranslational modification]; other site 101510018207 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 101510018208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510018209 S-adenosylmethionine binding site [chemical binding]; other site 101510018210 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 101510018211 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 101510018212 active site 101510018213 (T/H)XGH motif; other site 101510018214 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 101510018215 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 101510018216 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 101510018217 ribonuclease III; Reviewed; Region: rnc; PRK00102 101510018218 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 101510018219 dimerization interface [polypeptide binding]; other site 101510018220 active site 101510018221 metal binding site [ion binding]; metal-binding site 101510018222 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 101510018223 dsRNA binding site [nucleotide binding]; other site 101510018224 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 101510018225 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 101510018226 DNA binding site [nucleotide binding] 101510018227 catalytic residue [active] 101510018228 H2TH interface [polypeptide binding]; other site 101510018229 putative catalytic residues [active] 101510018230 turnover-facilitating residue; other site 101510018231 intercalation triad [nucleotide binding]; other site 101510018232 8OG recognition residue [nucleotide binding]; other site 101510018233 putative reading head residues; other site 101510018234 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 101510018235 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 101510018236 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 101510018237 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 101510018238 acylphosphatase; Provisional; Region: PRK14422 101510018239 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 101510018240 AAA domain; Region: AAA_23; pfam13476 101510018241 Walker A/P-loop; other site 101510018242 ATP binding site [chemical binding]; other site 101510018243 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 101510018244 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 101510018245 ABC transporter signature motif; other site 101510018246 Walker B; other site 101510018247 D-loop; other site 101510018248 H-loop/switch region; other site 101510018249 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 101510018250 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 101510018251 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510018252 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 101510018253 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 101510018254 Nitrogen regulatory protein P-II; Region: P-II; smart00938 101510018255 PII uridylyl-transferase; Provisional; Region: PRK03381 101510018256 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 101510018257 metal binding triad; other site 101510018258 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 101510018259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 101510018260 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 101510018261 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 101510018262 signal recognition particle protein; Provisional; Region: PRK10867 101510018263 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 101510018264 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 101510018265 P loop; other site 101510018266 GTP binding site [chemical binding]; other site 101510018267 Signal peptide binding domain; Region: SRP_SPB; pfam02978 101510018268 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 101510018269 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510018270 active site 101510018271 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 101510018272 hypothetical protein; Provisional; Region: PRK02821 101510018273 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 101510018274 G-X-X-G motif; other site 101510018275 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 101510018276 RimM N-terminal domain; Region: RimM; pfam01782 101510018277 PRC-barrel domain; Region: PRC; pfam05239 101510018278 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 101510018279 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 101510018280 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 101510018281 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 101510018282 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 101510018283 RNA binding site [nucleotide binding]; other site 101510018284 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 101510018285 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 101510018286 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 101510018287 Catalytic site [active] 101510018288 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 101510018289 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 101510018290 RNA/DNA hybrid binding site [nucleotide binding]; other site 101510018291 active site 101510018292 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 101510018293 hypothetical protein; Provisional; Region: PRK10279 101510018294 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 101510018295 active site 101510018296 nucleophile elbow; other site 101510018297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510018298 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510018299 putative substrate translocation pore; other site 101510018300 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 101510018301 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 101510018302 active site 101510018303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510018304 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510018305 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 101510018306 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510018307 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 101510018308 AsnC family; Region: AsnC_trans_reg; pfam01037 101510018309 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510018310 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510018311 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 101510018312 catalytic residue [active] 101510018313 hypothetical protein; Reviewed; Region: PRK12497 101510018314 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 101510018315 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 101510018316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510018317 Walker A motif; other site 101510018318 ATP binding site [chemical binding]; other site 101510018319 Walker B motif; other site 101510018320 arginine finger; other site 101510018321 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 101510018322 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 101510018323 DNA protecting protein DprA; Region: dprA; TIGR00732 101510018324 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 101510018325 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 101510018326 catalytic residues [active] 101510018327 catalytic nucleophile [active] 101510018328 Recombinase; Region: Recombinase; pfam07508 101510018329 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 101510018330 Helix-turn-helix domain; Region: HTH_36; pfam13730 101510018331 Phage capsid family; Region: Phage_capsid; pfam05065 101510018332 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 101510018333 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 101510018334 DNA protecting protein DprA; Region: dprA; TIGR00732 101510018335 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 101510018336 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510018337 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510018338 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 101510018339 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 101510018340 FAD binding pocket [chemical binding]; other site 101510018341 FAD binding motif [chemical binding]; other site 101510018342 phosphate binding motif [ion binding]; other site 101510018343 NAD binding pocket [chemical binding]; other site 101510018344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510018345 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 101510018346 putative substrate translocation pore; other site 101510018347 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 101510018348 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 101510018349 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 101510018350 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510018351 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510018352 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 101510018353 rRNA interaction site [nucleotide binding]; other site 101510018354 S8 interaction site; other site 101510018355 putative laminin-1 binding site; other site 101510018356 elongation factor Ts; Provisional; Region: tsf; PRK09377 101510018357 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 101510018358 Elongation factor TS; Region: EF_TS; pfam00889 101510018359 Elongation factor TS; Region: EF_TS; pfam00889 101510018360 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 101510018361 putative nucleotide binding site [chemical binding]; other site 101510018362 uridine monophosphate binding site [chemical binding]; other site 101510018363 homohexameric interface [polypeptide binding]; other site 101510018364 ribosome recycling factor; Reviewed; Region: frr; PRK00083 101510018365 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 101510018366 hinge region; other site 101510018367 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 101510018368 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 101510018369 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 101510018370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510018371 S-adenosylmethionine binding site [chemical binding]; other site 101510018372 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 101510018373 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 101510018374 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 101510018375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510018376 FeS/SAM binding site; other site 101510018377 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 101510018378 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 101510018379 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 101510018380 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 101510018381 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 101510018382 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 101510018383 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 101510018384 active site 101510018385 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 101510018386 protein binding site [polypeptide binding]; other site 101510018387 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 101510018388 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 101510018389 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 101510018390 Predicted acetyltransferase [General function prediction only]; Region: COG3393 101510018391 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 101510018392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 101510018393 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 101510018394 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 101510018395 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 101510018396 amino acid transporter; Region: 2A0306; TIGR00909 101510018397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510018398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510018399 DNA binding residues [nucleotide binding] 101510018400 dimerization interface [polypeptide binding]; other site 101510018401 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 101510018402 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 101510018403 active site 101510018404 acyl-activating enzyme (AAE) consensus motif; other site 101510018405 putative CoA binding site [chemical binding]; other site 101510018406 AMP binding site [chemical binding]; other site 101510018407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510018408 dimer interface [polypeptide binding]; other site 101510018409 conserved gate region; other site 101510018410 ABC-ATPase subunit interface; other site 101510018411 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 101510018412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510018413 dimer interface [polypeptide binding]; other site 101510018414 conserved gate region; other site 101510018415 putative PBP binding loops; other site 101510018416 ABC-ATPase subunit interface; other site 101510018417 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 101510018418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510018419 Walker A/P-loop; other site 101510018420 ATP binding site [chemical binding]; other site 101510018421 Q-loop/lid; other site 101510018422 ABC transporter signature motif; other site 101510018423 Walker B; other site 101510018424 D-loop; other site 101510018425 H-loop/switch region; other site 101510018426 TOBE domain; Region: TOBE_2; pfam08402 101510018427 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 101510018428 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 101510018429 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510018430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510018431 DNA-binding site [nucleotide binding]; DNA binding site 101510018432 UTRA domain; Region: UTRA; pfam07702 101510018433 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 101510018434 active site 101510018435 cobyric acid synthase; Provisional; Region: PRK00784 101510018436 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510018437 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 101510018438 catalytic triad [active] 101510018439 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 101510018440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 101510018441 Walker A/P-loop; other site 101510018442 ATP binding site [chemical binding]; other site 101510018443 Q-loop/lid; other site 101510018444 ABC transporter signature motif; other site 101510018445 Walker B; other site 101510018446 D-loop; other site 101510018447 H-loop/switch region; other site 101510018448 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510018449 hypothetical protein; Provisional; Region: PRK02237 101510018450 mycothione reductase; Reviewed; Region: PRK07846 101510018451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510018452 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 101510018453 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 101510018454 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510018455 malate:quinone oxidoreductase; Validated; Region: PRK05257 101510018456 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 101510018457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510018458 Coenzyme A binding pocket [chemical binding]; other site 101510018459 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 101510018460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510018461 Walker A motif; other site 101510018462 ATP binding site [chemical binding]; other site 101510018463 Walker B motif; other site 101510018464 arginine finger; other site 101510018465 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 101510018466 metal ion-dependent adhesion site (MIDAS); other site 101510018467 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 101510018468 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 101510018469 Walker A motif; other site 101510018470 homodimer interface [polypeptide binding]; other site 101510018471 ATP binding site [chemical binding]; other site 101510018472 hydroxycobalamin binding site [chemical binding]; other site 101510018473 Walker B motif; other site 101510018474 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 101510018475 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510018476 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 101510018477 catalytic triad [active] 101510018478 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 101510018479 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 101510018480 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 101510018481 homodimer interface [polypeptide binding]; other site 101510018482 active site 101510018483 SAM binding site [chemical binding]; other site 101510018484 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510018485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510018486 putative substrate translocation pore; other site 101510018487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510018488 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 101510018489 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 101510018490 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 101510018491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510018492 active site 101510018493 phosphorylation site [posttranslational modification] 101510018494 intermolecular recognition site; other site 101510018495 dimerization interface [polypeptide binding]; other site 101510018496 Transcriptional regulator; Region: CitT; pfam12431 101510018497 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510018498 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 101510018499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 101510018500 putative active site [active] 101510018501 heme pocket [chemical binding]; other site 101510018502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510018503 ATP binding site [chemical binding]; other site 101510018504 Mg2+ binding site [ion binding]; other site 101510018505 G-X-G motif; other site 101510018506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 101510018507 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 101510018508 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 101510018509 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 101510018510 Ligand Binding Site [chemical binding]; other site 101510018511 hypothetical protein; Validated; Region: PRK02101 101510018512 prolyl-tRNA synthetase; Provisional; Region: PRK09194 101510018513 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 101510018514 motif 1; other site 101510018515 dimer interface [polypeptide binding]; other site 101510018516 active site 101510018517 motif 2; other site 101510018518 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 101510018519 putative deacylase active site [active] 101510018520 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 101510018521 active site 101510018522 motif 3; other site 101510018523 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 101510018524 anticodon binding site; other site 101510018525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510018526 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510018527 active site 101510018528 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 101510018529 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 101510018530 putative dimer interface [polypeptide binding]; other site 101510018531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510018532 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 101510018533 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510018534 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510018535 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510018536 phosphopeptide binding site; other site 101510018537 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510018538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510018539 DNA binding residues [nucleotide binding] 101510018540 dimerization interface [polypeptide binding]; other site 101510018541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510018542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510018543 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510018544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510018545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510018546 short chain dehydrogenase; Provisional; Region: PRK08303 101510018547 NAD(P) binding site [chemical binding]; other site 101510018548 active site 101510018549 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510018550 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 101510018551 dinuclear metal binding motif [ion binding]; other site 101510018552 ribosome maturation protein RimP; Reviewed; Region: PRK00092 101510018553 Sm and related proteins; Region: Sm_like; cl00259 101510018554 heptamer interface [polypeptide binding]; other site 101510018555 Sm1 motif; other site 101510018556 hexamer interface [polypeptide binding]; other site 101510018557 RNA binding site [nucleotide binding]; other site 101510018558 Sm2 motif; other site 101510018559 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 101510018560 NusA N-terminal domain; Region: NusA_N; pfam08529 101510018561 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 101510018562 RNA binding site [nucleotide binding]; other site 101510018563 homodimer interface [polypeptide binding]; other site 101510018564 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 101510018565 G-X-X-G motif; other site 101510018566 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 101510018567 G-X-X-G motif; other site 101510018568 Protein of unknown function (DUF448); Region: DUF448; pfam04296 101510018569 putative RNA binding cleft [nucleotide binding]; other site 101510018570 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 101510018571 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 101510018572 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 101510018573 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 101510018574 G1 box; other site 101510018575 putative GEF interaction site [polypeptide binding]; other site 101510018576 GTP/Mg2+ binding site [chemical binding]; other site 101510018577 Switch I region; other site 101510018578 G2 box; other site 101510018579 G3 box; other site 101510018580 Switch II region; other site 101510018581 G4 box; other site 101510018582 G5 box; other site 101510018583 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 101510018584 Translation-initiation factor 2; Region: IF-2; pfam11987 101510018585 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 101510018586 Protein of unknown function (DUF503); Region: DUF503; pfam04456 101510018587 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 101510018588 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 101510018589 DHH family; Region: DHH; pfam01368 101510018590 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 101510018591 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 101510018592 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 101510018593 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 101510018594 active site 101510018595 metal binding site [ion binding]; metal-binding site 101510018596 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 101510018597 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 101510018598 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 101510018599 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 101510018600 RNA binding site [nucleotide binding]; other site 101510018601 active site 101510018602 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 101510018603 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 101510018604 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 101510018605 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 101510018606 FeoA domain; Region: FeoA; pfam04023 101510018607 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 101510018608 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 101510018609 active site 101510018610 Riboflavin kinase; Region: Flavokinase; smart00904 101510018611 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 101510018612 16S/18S rRNA binding site [nucleotide binding]; other site 101510018613 S13e-L30e interaction site [polypeptide binding]; other site 101510018614 25S rRNA binding site [nucleotide binding]; other site 101510018615 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 101510018616 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 101510018617 oligomer interface [polypeptide binding]; other site 101510018618 RNA binding site [nucleotide binding]; other site 101510018619 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 101510018620 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 101510018621 RNase E interface [polypeptide binding]; other site 101510018622 trimer interface [polypeptide binding]; other site 101510018623 active site 101510018624 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 101510018625 putative nucleic acid binding region [nucleotide binding]; other site 101510018626 G-X-X-G motif; other site 101510018627 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 101510018628 RNA binding site [nucleotide binding]; other site 101510018629 domain interface; other site 101510018630 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 101510018631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510018632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510018633 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 101510018634 putative dimerization interface [polypeptide binding]; other site 101510018635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510018636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510018637 putative substrate translocation pore; other site 101510018638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510018639 S-adenosylmethionine binding site [chemical binding]; other site 101510018640 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 101510018641 putative hydrophobic ligand binding site [chemical binding]; other site 101510018642 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510018643 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510018644 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510018645 Condensation domain; Region: Condensation; pfam00668 101510018646 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510018647 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510018648 acyl-activating enzyme (AAE) consensus motif; other site 101510018649 AMP binding site [chemical binding]; other site 101510018650 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510018651 Condensation domain; Region: Condensation; pfam00668 101510018652 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510018653 Condensation domain; Region: Condensation; pfam00668 101510018654 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510018655 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510018656 acyl-activating enzyme (AAE) consensus motif; other site 101510018657 AMP binding site [chemical binding]; other site 101510018658 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510018659 Condensation domain; Region: Condensation; pfam00668 101510018660 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 101510018661 Condensation domain; Region: Condensation; pfam00668 101510018662 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510018663 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510018664 acyl-activating enzyme (AAE) consensus motif; other site 101510018665 AMP binding site [chemical binding]; other site 101510018666 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510018667 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 101510018668 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510018669 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510018670 acyl-activating enzyme (AAE) consensus motif; other site 101510018671 AMP binding site [chemical binding]; other site 101510018672 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510018673 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 101510018674 Glutamine amidotransferase class-I; Region: GATase; pfam00117 101510018675 glutamine binding [chemical binding]; other site 101510018676 catalytic triad [active] 101510018677 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 101510018678 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 101510018679 chorismate binding enzyme; Region: Chorismate_bind; cl10555 101510018680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510018681 S-adenosylmethionine binding site [chemical binding]; other site 101510018682 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 101510018683 DEAD-like helicases superfamily; Region: DEXDc; smart00487 101510018684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510018685 ATP binding site [chemical binding]; other site 101510018686 putative Mg++ binding site [ion binding]; other site 101510018687 Helicase_C-like; Region: Helicase_C_4; pfam13871 101510018688 D-galactonate transporter; Region: 2A0114; TIGR00893 101510018689 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510018690 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510018691 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510018692 FMN-binding pocket [chemical binding]; other site 101510018693 flavin binding motif; other site 101510018694 phosphate binding motif [ion binding]; other site 101510018695 beta-alpha-beta structure motif; other site 101510018696 NAD binding pocket [chemical binding]; other site 101510018697 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510018698 catalytic loop [active] 101510018699 iron binding site [ion binding]; other site 101510018700 YCII-related domain; Region: YCII; cl00999 101510018701 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510018702 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510018703 NAD(P) binding site [chemical binding]; other site 101510018704 catalytic residues [active] 101510018705 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510018706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510018707 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 101510018708 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510018709 enoyl-CoA hydratase; Provisional; Region: PRK09245 101510018710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510018711 substrate binding site [chemical binding]; other site 101510018712 oxyanion hole (OAH) forming residues; other site 101510018713 trimer interface [polypeptide binding]; other site 101510018714 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510018715 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510018716 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510018717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510018718 active site 101510018719 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510018720 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510018721 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510018722 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510018723 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 101510018724 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510018725 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510018726 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510018727 substrate binding pocket [chemical binding]; other site 101510018728 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510018729 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510018730 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510018731 catalytic site [active] 101510018732 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 101510018733 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 101510018734 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 101510018735 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 101510018736 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 101510018737 putative NADH binding site [chemical binding]; other site 101510018738 putative active site [active] 101510018739 nudix motif; other site 101510018740 putative metal binding site [ion binding]; other site 101510018741 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510018742 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 101510018743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510018744 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 101510018745 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510018746 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 101510018747 dimer interface [polypeptide binding]; other site 101510018748 acyl-activating enzyme (AAE) consensus motif; other site 101510018749 putative active site [active] 101510018750 AMP binding site [chemical binding]; other site 101510018751 putative CoA binding site [chemical binding]; other site 101510018752 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 101510018753 Strictosidine synthase; Region: Str_synth; pfam03088 101510018754 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 101510018755 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510018756 FMN binding site [chemical binding]; other site 101510018757 substrate binding site [chemical binding]; other site 101510018758 putative catalytic residue [active] 101510018759 enoyl-CoA hydratase; Provisional; Region: PRK08260 101510018760 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510018761 substrate binding site [chemical binding]; other site 101510018762 oxyanion hole (OAH) forming residues; other site 101510018763 trimer interface [polypeptide binding]; other site 101510018764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510018765 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510018766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510018767 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 101510018768 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 101510018769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510018770 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 101510018771 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 101510018772 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 101510018773 thioredoxin 2; Provisional; Region: PRK10996 101510018774 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 101510018775 catalytic residues [active] 101510018776 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 101510018777 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 101510018778 Clp amino terminal domain; Region: Clp_N; pfam02861 101510018779 Clp amino terminal domain; Region: Clp_N; pfam02861 101510018780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510018781 Walker A motif; other site 101510018782 ATP binding site [chemical binding]; other site 101510018783 Walker B motif; other site 101510018784 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 101510018785 arginine finger; other site 101510018786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510018787 Walker A motif; other site 101510018788 ATP binding site [chemical binding]; other site 101510018789 Walker B motif; other site 101510018790 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 101510018791 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 101510018792 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 101510018793 HSP70 interaction site [polypeptide binding]; other site 101510018794 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 101510018795 substrate binding site [polypeptide binding]; other site 101510018796 dimer interface [polypeptide binding]; other site 101510018797 heat shock protein GrpE; Provisional; Region: PRK14140 101510018798 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 101510018799 dimer interface [polypeptide binding]; other site 101510018800 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 101510018801 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 101510018802 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 101510018803 nucleotide binding site [chemical binding]; other site 101510018804 NEF interaction site [polypeptide binding]; other site 101510018805 SBD interface [polypeptide binding]; other site 101510018806 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510018807 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 101510018808 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 101510018809 protein binding site [polypeptide binding]; other site 101510018810 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 101510018811 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 101510018812 putative hydrophobic ligand binding site [chemical binding]; other site 101510018813 Methyltransferase domain; Region: Methyltransf_23; pfam13489 101510018814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510018815 S-adenosylmethionine binding site [chemical binding]; other site 101510018816 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 101510018817 putative hydrophobic ligand binding site [chemical binding]; other site 101510018818 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510018819 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510018820 mce related protein; Region: MCE; pfam02470 101510018821 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 101510018822 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510018823 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510018824 active site 101510018825 ATP binding site [chemical binding]; other site 101510018826 substrate binding site [chemical binding]; other site 101510018827 activation loop (A-loop); other site 101510018828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510018829 S-adenosylmethionine binding site [chemical binding]; other site 101510018830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510018831 Hemerythrin-like domain; Region: Hr-like; cd12108 101510018832 Fe binding site [ion binding]; other site 101510018833 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510018834 hydrophobic ligand binding site; other site 101510018835 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 101510018836 Domain of unknown function DUF77; Region: DUF77; pfam01910 101510018837 Predicted transcriptional regulator [Transcription]; Region: COG2378 101510018838 HTH domain; Region: HTH_11; pfam08279 101510018839 WYL domain; Region: WYL; pfam13280 101510018840 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510018841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510018842 active site 101510018843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 101510018844 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 101510018845 DinB superfamily; Region: DinB_2; pfam12867 101510018846 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510018847 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510018848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510018849 S-adenosylmethionine binding site [chemical binding]; other site 101510018850 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 101510018851 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 101510018852 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 101510018853 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 101510018854 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510018855 NAD(P) binding site [chemical binding]; other site 101510018856 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 101510018857 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 101510018858 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510018859 MarR family; Region: MarR_2; pfam12802 101510018860 TIGR03086 family protein; Region: TIGR03086 101510018861 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510018862 dihydrodipicolinate reductase; Provisional; Region: PRK00048 101510018863 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 101510018864 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 101510018865 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 101510018866 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 101510018867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 101510018868 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 101510018869 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 101510018870 putative hydrophobic ligand binding site [chemical binding]; other site 101510018871 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 101510018872 HicB family; Region: HicB; pfam05534 101510018873 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 101510018874 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 101510018875 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 101510018876 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 101510018877 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510018878 dimer interface [polypeptide binding]; other site 101510018879 active site 101510018880 catalytic residue [active] 101510018881 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 101510018882 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510018883 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 101510018884 TIGR03085 family protein; Region: TIGR03085 101510018885 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 101510018886 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 101510018887 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 101510018888 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 101510018889 YCII-related domain; Region: YCII; cl00999 101510018890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510018891 Coenzyme A binding pocket [chemical binding]; other site 101510018892 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 101510018893 Competence-damaged protein; Region: CinA; pfam02464 101510018894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510018895 non-specific DNA binding site [nucleotide binding]; other site 101510018896 salt bridge; other site 101510018897 sequence-specific DNA binding site [nucleotide binding]; other site 101510018898 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 101510018899 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 101510018900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510018901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510018902 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 101510018903 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 101510018904 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 101510018905 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 101510018906 recombinase A; Provisional; Region: recA; PRK09354 101510018907 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 101510018908 hexamer interface [polypeptide binding]; other site 101510018909 Walker A motif; other site 101510018910 ATP binding site [chemical binding]; other site 101510018911 Walker B motif; other site 101510018912 recombination regulator RecX; Reviewed; Region: recX; PRK00117 101510018913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510018914 dimer interface [polypeptide binding]; other site 101510018915 conserved gate region; other site 101510018916 putative PBP binding loops; other site 101510018917 ABC-ATPase subunit interface; other site 101510018918 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 101510018919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510018920 dimer interface [polypeptide binding]; other site 101510018921 conserved gate region; other site 101510018922 putative PBP binding loops; other site 101510018923 ABC-ATPase subunit interface; other site 101510018924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510018925 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510018926 substrate binding pocket [chemical binding]; other site 101510018927 membrane-bound complex binding site; other site 101510018928 hinge residues; other site 101510018929 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510018930 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510018931 Walker A/P-loop; other site 101510018932 ATP binding site [chemical binding]; other site 101510018933 Q-loop/lid; other site 101510018934 ABC transporter signature motif; other site 101510018935 Walker B; other site 101510018936 D-loop; other site 101510018937 H-loop/switch region; other site 101510018938 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 101510018939 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 101510018940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510018941 FeS/SAM binding site; other site 101510018942 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 101510018943 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 101510018944 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 101510018945 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 101510018946 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 101510018947 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 101510018948 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 101510018949 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 101510018950 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 101510018951 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 101510018952 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 101510018953 GTPases [General function prediction only]; Region: HflX; COG2262 101510018954 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 101510018955 HflX GTPase family; Region: HflX; cd01878 101510018956 G1 box; other site 101510018957 GTP/Mg2+ binding site [chemical binding]; other site 101510018958 Switch I region; other site 101510018959 G2 box; other site 101510018960 G3 box; other site 101510018961 Switch II region; other site 101510018962 G4 box; other site 101510018963 G5 box; other site 101510018964 Putative esterase; Region: Esterase; pfam00756 101510018965 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 101510018966 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 101510018967 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 101510018968 active site 101510018969 phosphorylation site [posttranslational modification] 101510018970 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 101510018971 active site 101510018972 P-loop; other site 101510018973 phosphorylation site [posttranslational modification] 101510018974 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 101510018975 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 101510018976 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 101510018977 putative substrate binding site [chemical binding]; other site 101510018978 putative ATP binding site [chemical binding]; other site 101510018979 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 101510018980 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 101510018981 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 101510018982 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 101510018983 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 101510018984 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 101510018985 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 101510018986 uracil transporter; Provisional; Region: PRK10720 101510018987 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 101510018988 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510018989 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510018990 active site 101510018991 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 101510018992 LexA repressor; Validated; Region: PRK00215 101510018993 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 101510018994 Catalytic site [active] 101510018995 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 101510018996 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 101510018997 ATP cone domain; Region: ATP-cone; pfam03477 101510018998 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 101510018999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510019000 ATP binding site [chemical binding]; other site 101510019001 putative Mg++ binding site [ion binding]; other site 101510019002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510019003 nucleotide binding region [chemical binding]; other site 101510019004 ATP-binding site [chemical binding]; other site 101510019005 Helicase associated domain (HA2); Region: HA2; pfam04408 101510019006 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 101510019007 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 101510019008 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510019009 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510019010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019011 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510019012 putative substrate translocation pore; other site 101510019013 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 101510019014 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510019015 inhibitor-cofactor binding pocket; inhibition site 101510019016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510019017 catalytic residue [active] 101510019018 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 101510019019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510019020 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 101510019021 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 101510019022 dimerization interface [polypeptide binding]; other site 101510019023 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510019024 dimerization interface [polypeptide binding]; other site 101510019025 substrate binding pocket [chemical binding]; other site 101510019026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510019027 ATP binding site [chemical binding]; other site 101510019028 putative Mg++ binding site [ion binding]; other site 101510019029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510019030 nucleotide binding region [chemical binding]; other site 101510019031 ATP-binding site [chemical binding]; other site 101510019032 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 101510019033 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510019034 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510019035 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510019036 PAC2 family; Region: PAC2; pfam09754 101510019037 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510019038 PknH-like extracellular domain; Region: PknH_C; pfam14032 101510019039 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 101510019040 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 101510019041 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 101510019042 NAD binding site [chemical binding]; other site 101510019043 homodimer interface [polypeptide binding]; other site 101510019044 active site 101510019045 substrate binding site [chemical binding]; other site 101510019046 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 101510019047 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 101510019048 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 101510019049 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 101510019050 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 101510019051 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 101510019052 active site 101510019053 Zn binding site [ion binding]; other site 101510019054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 101510019055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510019056 Coenzyme A binding pocket [chemical binding]; other site 101510019057 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 101510019058 CoA binding domain; Region: CoA_binding_2; pfam13380 101510019059 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 101510019060 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 101510019061 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 101510019062 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 101510019063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510019064 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 101510019065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510019066 DNA binding residues [nucleotide binding] 101510019067 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 101510019068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510019069 S-adenosylmethionine binding site [chemical binding]; other site 101510019070 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 101510019071 Membrane-associated tegument protein; Region: UL11; cl17374 101510019072 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 101510019073 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 101510019074 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 101510019075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510019076 ATP binding site [chemical binding]; other site 101510019077 putative Mg++ binding site [ion binding]; other site 101510019078 Protein of unknown function (DUF952); Region: DUF952; cl01393 101510019079 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 101510019080 TrkA-C domain; Region: TrkA_C; pfam02080 101510019081 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 101510019082 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 101510019083 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 101510019084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510019085 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 101510019086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510019087 DNA binding residues [nucleotide binding] 101510019088 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 101510019089 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510019090 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 101510019091 active site 101510019092 dimerization interface [polypeptide binding]; other site 101510019093 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 101510019094 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 101510019095 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 101510019096 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 101510019097 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 101510019098 trimer interface [polypeptide binding]; other site 101510019099 active site 101510019100 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 101510019101 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510019102 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 101510019103 generic binding surface II; other site 101510019104 ssDNA binding site; other site 101510019105 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 101510019106 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 101510019107 TrkA-N domain; Region: TrkA_N; pfam02254 101510019108 TrkA-C domain; Region: TrkA_C; pfam02080 101510019109 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 101510019110 TrkA-N domain; Region: TrkA_N; pfam02254 101510019111 TrkA-C domain; Region: TrkA_C; pfam02080 101510019112 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510019113 TRAM domain; Region: TRAM; pfam01938 101510019114 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 101510019115 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510019116 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510019117 putative DNA binding site [nucleotide binding]; other site 101510019118 putative Zn2+ binding site [ion binding]; other site 101510019119 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 101510019120 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510019121 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510019122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510019123 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 101510019124 Walker A/P-loop; other site 101510019125 ATP binding site [chemical binding]; other site 101510019126 Q-loop/lid; other site 101510019127 ABC transporter signature motif; other site 101510019128 Walker B; other site 101510019129 D-loop; other site 101510019130 H-loop/switch region; other site 101510019131 glutaminase; Provisional; Region: PRK00971 101510019132 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 101510019133 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 101510019134 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 101510019135 ligand binding site [chemical binding]; other site 101510019136 flexible hinge region; other site 101510019137 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 101510019138 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 101510019139 TPP-binding site; other site 101510019140 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 101510019141 PYR/PP interface [polypeptide binding]; other site 101510019142 dimer interface [polypeptide binding]; other site 101510019143 TPP binding site [chemical binding]; other site 101510019144 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510019145 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 101510019146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019147 putative substrate translocation pore; other site 101510019148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019149 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 101510019150 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 101510019151 siderophore binding site; other site 101510019152 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510019153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510019154 DNA-binding site [nucleotide binding]; DNA binding site 101510019155 UTRA domain; Region: UTRA; pfam07702 101510019156 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 101510019157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 101510019158 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 101510019159 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510019160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510019161 dimer interface [polypeptide binding]; other site 101510019162 conserved gate region; other site 101510019163 putative PBP binding loops; other site 101510019164 ABC-ATPase subunit interface; other site 101510019165 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510019166 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 101510019167 Walker A/P-loop; other site 101510019168 ATP binding site [chemical binding]; other site 101510019169 Q-loop/lid; other site 101510019170 ABC transporter signature motif; other site 101510019171 Walker B; other site 101510019172 D-loop; other site 101510019173 H-loop/switch region; other site 101510019174 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 101510019175 L-aspartate oxidase; Provisional; Region: PRK06175 101510019176 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 101510019177 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 101510019178 protein binding surface [polypeptide binding]; other site 101510019179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510019180 substrate binding site [chemical binding]; other site 101510019181 oxyanion hole (OAH) forming residues; other site 101510019182 trimer interface [polypeptide binding]; other site 101510019183 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 101510019184 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510019185 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510019186 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510019187 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 101510019188 dimer interface [polypeptide binding]; other site 101510019189 active site 101510019190 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 101510019191 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 101510019192 catalytic site [active] 101510019193 putative active site [active] 101510019194 putative substrate binding site [chemical binding]; other site 101510019195 Helicase and RNase D C-terminal; Region: HRDC; smart00341 101510019196 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510019197 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510019198 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510019199 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510019200 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 101510019201 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 101510019202 substrate binding site [chemical binding]; other site 101510019203 active site 101510019204 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 101510019205 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 101510019206 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 101510019207 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 101510019208 molybdopterin cofactor binding site [chemical binding]; other site 101510019209 substrate binding site [chemical binding]; other site 101510019210 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 101510019211 molybdopterin cofactor binding site; other site 101510019212 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 101510019213 SelR domain; Region: SelR; pfam01641 101510019214 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 101510019215 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510019216 TAP-like protein; Region: Abhydrolase_4; pfam08386 101510019217 hypothetical protein; Provisional; Region: PRK14059 101510019218 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 101510019219 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 101510019220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510019221 Walker A motif; other site 101510019222 ATP binding site [chemical binding]; other site 101510019223 Walker B motif; other site 101510019224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 101510019225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510019226 Coenzyme A binding pocket [chemical binding]; other site 101510019227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019228 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 101510019229 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 101510019230 hypothetical protein; Reviewed; Region: PRK09588 101510019231 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 101510019232 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 101510019233 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 101510019234 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 101510019235 active site 101510019236 dimer interface [polypeptide binding]; other site 101510019237 motif 1; other site 101510019238 motif 2; other site 101510019239 motif 3; other site 101510019240 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 101510019241 anticodon binding site; other site 101510019242 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 101510019243 nucleotide binding site/active site [active] 101510019244 HIT family signature motif; other site 101510019245 catalytic residue [active] 101510019246 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 101510019247 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 101510019248 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 101510019249 putative acyl-acceptor binding pocket; other site 101510019250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 101510019251 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 101510019252 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 101510019253 nudix motif; other site 101510019254 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 101510019255 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 101510019256 active site 101510019257 multimer interface [polypeptide binding]; other site 101510019258 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 101510019259 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 101510019260 active site 101510019261 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 101510019262 catalytic triad [active] 101510019263 dimer interface [polypeptide binding]; other site 101510019264 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 101510019265 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 101510019266 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 101510019267 active site 101510019268 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 101510019269 catalytic triad [active] 101510019270 dimer interface [polypeptide binding]; other site 101510019271 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 101510019272 predicted active site [active] 101510019273 catalytic triad [active] 101510019274 Predicted transcriptional regulators [Transcription]; Region: COG1725 101510019275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510019276 DNA-binding site [nucleotide binding]; DNA binding site 101510019277 hypothetical protein; Validated; Region: PRK00110 101510019278 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 101510019279 active site 101510019280 putative DNA-binding cleft [nucleotide binding]; other site 101510019281 dimer interface [polypeptide binding]; other site 101510019282 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 101510019283 RuvA N terminal domain; Region: RuvA_N; pfam01330 101510019284 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 101510019285 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 101510019286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510019287 Walker A motif; other site 101510019288 ATP binding site [chemical binding]; other site 101510019289 Walker B motif; other site 101510019290 arginine finger; other site 101510019291 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 101510019292 Preprotein translocase subunit; Region: YajC; cl00806 101510019293 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 101510019294 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 101510019295 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 101510019296 Protein export membrane protein; Region: SecD_SecF; pfam02355 101510019297 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 101510019298 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 101510019299 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 101510019300 active site 101510019301 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 101510019302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 101510019303 Zn2+ binding site [ion binding]; other site 101510019304 Mg2+ binding site [ion binding]; other site 101510019305 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 101510019306 synthetase active site [active] 101510019307 NTP binding site [chemical binding]; other site 101510019308 metal binding site [ion binding]; metal-binding site 101510019309 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 101510019310 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 101510019311 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 101510019312 active site 101510019313 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 101510019314 active site 101510019315 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 101510019316 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 101510019317 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 101510019318 dimer interface [polypeptide binding]; other site 101510019319 motif 1; other site 101510019320 active site 101510019321 motif 2; other site 101510019322 motif 3; other site 101510019323 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 101510019324 anticodon binding site; other site 101510019325 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 101510019326 putative transposase OrfB; Reviewed; Region: PHA02517 101510019327 HTH-like domain; Region: HTH_21; pfam13276 101510019328 Integrase core domain; Region: rve; pfam00665 101510019329 Integrase core domain; Region: rve_3; pfam13683 101510019330 Transposase; Region: HTH_Tnp_1; cl17663 101510019331 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 101510019332 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 101510019333 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510019334 active site 101510019335 catalytic residues [active] 101510019336 DNA binding site [nucleotide binding] 101510019337 Int/Topo IB signature motif; other site 101510019338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 101510019339 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510019340 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 101510019341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510019342 Walker A motif; other site 101510019343 ATP binding site [chemical binding]; other site 101510019344 Walker B motif; other site 101510019345 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510019346 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510019347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510019348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510019349 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 101510019350 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 101510019351 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 101510019352 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 101510019353 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 101510019354 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 101510019355 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 101510019356 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 101510019357 RibD C-terminal domain; Region: RibD_C; cl17279 101510019358 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 101510019359 putative hydrophobic ligand binding site [chemical binding]; other site 101510019360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510019361 dimerization interface [polypeptide binding]; other site 101510019362 putative DNA binding site [nucleotide binding]; other site 101510019363 putative Zn2+ binding site [ion binding]; other site 101510019364 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 101510019365 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 101510019366 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 101510019367 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 101510019368 Zn2+ binding site [ion binding]; other site 101510019369 Mg2+ binding site [ion binding]; other site 101510019370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510019371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510019372 DNA binding residues [nucleotide binding] 101510019373 dimerization interface [polypeptide binding]; other site 101510019374 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 101510019375 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 101510019376 Walker A/P-loop; other site 101510019377 ATP binding site [chemical binding]; other site 101510019378 Q-loop/lid; other site 101510019379 ABC transporter signature motif; other site 101510019380 Walker B; other site 101510019381 D-loop; other site 101510019382 H-loop/switch region; other site 101510019383 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510019384 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510019385 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510019386 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 101510019387 Transglycosylase; Region: Transgly; pfam00912 101510019388 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 101510019389 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 101510019390 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 101510019391 nucleotide binding site [chemical binding]; other site 101510019392 NEF interaction site [polypeptide binding]; other site 101510019393 SBD interface [polypeptide binding]; other site 101510019394 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 101510019395 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 101510019396 dimer interface [polypeptide binding]; other site 101510019397 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 101510019398 chaperone protein DnaJ; Provisional; Region: PRK14279 101510019399 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 101510019400 HSP70 interaction site [polypeptide binding]; other site 101510019401 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 101510019402 Zn binding sites [ion binding]; other site 101510019403 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 101510019404 dimer interface [polypeptide binding]; other site 101510019405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510019406 Predicted ATPase [General function prediction only]; Region: COG3903 101510019407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510019408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510019409 DNA binding residues [nucleotide binding] 101510019410 dimerization interface [polypeptide binding]; other site 101510019411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510019412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510019413 active site 101510019414 ATP binding site [chemical binding]; other site 101510019415 substrate binding site [chemical binding]; other site 101510019416 activation loop (A-loop); other site 101510019417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510019418 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510019419 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510019420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 101510019421 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510019422 active site residue [active] 101510019423 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510019424 active site residue [active] 101510019425 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 101510019426 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 101510019427 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 101510019428 dimer interface [polypeptide binding]; other site 101510019429 decamer (pentamer of dimers) interface [polypeptide binding]; other site 101510019430 catalytic triad [active] 101510019431 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 101510019432 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 101510019433 Walker A/P-loop; other site 101510019434 ATP binding site [chemical binding]; other site 101510019435 Q-loop/lid; other site 101510019436 ABC transporter signature motif; other site 101510019437 Walker B; other site 101510019438 D-loop; other site 101510019439 H-loop/switch region; other site 101510019440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510019441 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 101510019442 substrate binding pocket [chemical binding]; other site 101510019443 membrane-bound complex binding site; other site 101510019444 hinge residues; other site 101510019445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510019446 dimer interface [polypeptide binding]; other site 101510019447 conserved gate region; other site 101510019448 putative PBP binding loops; other site 101510019449 ABC-ATPase subunit interface; other site 101510019450 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 101510019451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510019452 dimer interface [polypeptide binding]; other site 101510019453 conserved gate region; other site 101510019454 putative PBP binding loops; other site 101510019455 ABC-ATPase subunit interface; other site 101510019456 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510019457 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510019458 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510019459 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510019460 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510019461 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 101510019462 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 101510019463 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 101510019464 active site 101510019465 citrylCoA binding site [chemical binding]; other site 101510019466 oxalacetate binding site [chemical binding]; other site 101510019467 coenzyme A binding site [chemical binding]; other site 101510019468 catalytic triad [active] 101510019469 Putative cyclase; Region: Cyclase; pfam04199 101510019470 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510019471 CoenzymeA binding site [chemical binding]; other site 101510019472 subunit interaction site [polypeptide binding]; other site 101510019473 PHB binding site; other site 101510019474 hypothetical protein; Validated; Region: PRK06201 101510019475 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 101510019476 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 101510019477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510019479 putative substrate translocation pore; other site 101510019480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019481 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 101510019482 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 101510019483 PhoU domain; Region: PhoU; pfam01895 101510019484 PhoU domain; Region: PhoU; pfam01895 101510019485 Short C-terminal domain; Region: SHOCT; pfam09851 101510019486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510019487 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510019488 active site 101510019489 DNA binding site [nucleotide binding] 101510019490 Int/Topo IB signature motif; other site 101510019491 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 101510019492 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 101510019493 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510019494 active site 101510019495 DNA binding site [nucleotide binding] 101510019496 Int/Topo IB signature motif; other site 101510019497 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 101510019498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510019499 ATP binding site [chemical binding]; other site 101510019500 Walker A motif; other site 101510019501 Walker B motif; other site 101510019502 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 101510019503 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 101510019504 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 101510019505 Prostaglandin dehydrogenases; Region: PGDH; cd05288 101510019506 NAD(P) binding site [chemical binding]; other site 101510019507 substrate binding site [chemical binding]; other site 101510019508 dimer interface [polypeptide binding]; other site 101510019509 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 101510019510 NodB motif; other site 101510019511 putative active site [active] 101510019512 putative catalytic site [active] 101510019513 putative Zn binding site [ion binding]; other site 101510019514 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 101510019515 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 101510019516 acyl-activating enzyme (AAE) consensus motif; other site 101510019517 putative AMP binding site [chemical binding]; other site 101510019518 putative active site [active] 101510019519 putative CoA binding site [chemical binding]; other site 101510019520 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510019521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510019522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510019523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510019524 NAD(P) binding site [chemical binding]; other site 101510019525 active site 101510019526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510019527 Cupin domain; Region: Cupin_2; pfam07883 101510019528 Secretory lipase; Region: LIP; pfam03583 101510019529 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 101510019530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510019531 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 101510019532 active site 101510019533 catalytic site [active] 101510019534 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510019535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510019536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510019537 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 101510019538 putative hydrophobic ligand binding site [chemical binding]; other site 101510019539 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 101510019540 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510019541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510019542 Homeodomain-like domain; Region: HTH_23; pfam13384 101510019543 Winged helix-turn helix; Region: HTH_29; pfam13551 101510019544 Homeodomain-like domain; Region: HTH_32; pfam13565 101510019545 Secretory lipase; Region: LIP; pfam03583 101510019546 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 101510019547 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510019548 TIGR03118 family protein; Region: PEPCTERM_chp_1 101510019549 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 101510019550 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 101510019551 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 101510019552 Walker A/P-loop; other site 101510019553 ATP binding site [chemical binding]; other site 101510019554 Q-loop/lid; other site 101510019555 ABC transporter signature motif; other site 101510019556 Walker B; other site 101510019557 D-loop; other site 101510019558 H-loop/switch region; other site 101510019559 TOBE domain; Region: TOBE_2; pfam08402 101510019560 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 101510019561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510019562 putative PBP binding loops; other site 101510019563 ABC-ATPase subunit interface; other site 101510019564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510019565 dimer interface [polypeptide binding]; other site 101510019566 conserved gate region; other site 101510019567 putative PBP binding loops; other site 101510019568 ABC-ATPase subunit interface; other site 101510019569 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 101510019570 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 101510019571 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 101510019572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510019573 active site 101510019574 CoA binding site [chemical binding]; other site 101510019575 AMP binding site [chemical binding]; other site 101510019576 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510019577 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 101510019578 putative active site [active] 101510019579 redox center [active] 101510019580 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 101510019581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 101510019582 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 101510019583 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 101510019584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510019585 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 101510019586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510019587 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 101510019588 Walker A/P-loop; other site 101510019589 ATP binding site [chemical binding]; other site 101510019590 Q-loop/lid; other site 101510019591 ABC transporter signature motif; other site 101510019592 Walker B; other site 101510019593 D-loop; other site 101510019594 H-loop/switch region; other site 101510019595 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510019596 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 101510019597 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 101510019598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 101510019599 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 101510019600 DNA binding residues [nucleotide binding] 101510019601 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 101510019602 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510019603 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510019604 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510019605 NMT1/THI5 like; Region: NMT1; pfam09084 101510019606 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510019607 substrate binding pocket [chemical binding]; other site 101510019608 membrane-bound complex binding site; other site 101510019609 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510019610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510019611 dimer interface [polypeptide binding]; other site 101510019612 conserved gate region; other site 101510019613 putative PBP binding loops; other site 101510019614 ABC-ATPase subunit interface; other site 101510019615 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510019616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510019617 Walker A/P-loop; other site 101510019618 ATP binding site [chemical binding]; other site 101510019619 Q-loop/lid; other site 101510019620 ABC transporter signature motif; other site 101510019621 Walker B; other site 101510019622 D-loop; other site 101510019623 H-loop/switch region; other site 101510019624 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 101510019625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 101510019626 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510019627 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 101510019628 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 101510019629 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510019630 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 101510019631 Zn2+ binding site [ion binding]; other site 101510019632 intersubunit interface [polypeptide binding]; other site 101510019633 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 101510019634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 101510019635 substrate binding pocket [chemical binding]; other site 101510019636 membrane-bound complex binding site; other site 101510019637 hinge residues; other site 101510019638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510019639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510019640 ATP binding site [chemical binding]; other site 101510019641 Mg2+ binding site [ion binding]; other site 101510019642 G-X-G motif; other site 101510019643 Lsr2; Region: Lsr2; pfam11774 101510019644 Lsr2; Region: Lsr2; pfam11774 101510019645 Lsr2; Region: Lsr2; pfam11774 101510019646 Lsr2; Region: Lsr2; pfam11774 101510019647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510019648 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510019649 active site 101510019650 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 101510019651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510019652 active site 101510019653 enoyl-CoA hydratase; Provisional; Region: PRK06495 101510019654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510019655 substrate binding site [chemical binding]; other site 101510019656 oxyanion hole (OAH) forming residues; other site 101510019657 trimer interface [polypeptide binding]; other site 101510019658 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 101510019659 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 101510019660 acyl-activating enzyme (AAE) consensus motif; other site 101510019661 putative AMP binding site [chemical binding]; other site 101510019662 putative active site [active] 101510019663 putative CoA binding site [chemical binding]; other site 101510019664 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510019665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510019666 DNA-binding site [nucleotide binding]; DNA binding site 101510019667 FCD domain; Region: FCD; pfam07729 101510019668 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510019669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019670 putative substrate translocation pore; other site 101510019671 enoyl-CoA hydratase; Provisional; Region: PRK05862 101510019672 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510019673 substrate binding site [chemical binding]; other site 101510019674 oxyanion hole (OAH) forming residues; other site 101510019675 trimer interface [polypeptide binding]; other site 101510019676 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 101510019677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510019678 substrate binding site [chemical binding]; other site 101510019679 oxyanion hole (OAH) forming residues; other site 101510019680 trimer interface [polypeptide binding]; other site 101510019681 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 101510019682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510019683 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 101510019684 substrate binding pocket [chemical binding]; other site 101510019685 FAD binding site [chemical binding]; other site 101510019686 catalytic base [active] 101510019687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510019688 MarR family; Region: MarR_2; pfam12802 101510019689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510019690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510019691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 101510019692 dimerization interface [polypeptide binding]; other site 101510019693 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510019694 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510019695 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510019696 Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108 101510019697 NAD(P) binding site [chemical binding]; other site 101510019698 catalytic residues [active] 101510019699 catalytic residues [active] 101510019700 adenylate kinase; Reviewed; Region: adk; PRK00279 101510019701 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 101510019702 AMP-binding site [chemical binding]; other site 101510019703 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 101510019704 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510019705 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 101510019706 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510019707 MULE transposase domain; Region: MULE; pfam10551 101510019708 Epoxide hydrolase N terminus; Region: EHN; pfam06441 101510019709 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510019710 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 101510019711 CGNR zinc finger; Region: zf-CGNR; pfam11706 101510019712 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 101510019713 Cupin domain; Region: Cupin_2; cl17218 101510019714 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510019715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510019716 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510019717 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 101510019718 inhibitor site; inhibition site 101510019719 active site 101510019720 dimer interface [polypeptide binding]; other site 101510019721 catalytic residue [active] 101510019722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019723 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510019724 putative substrate translocation pore; other site 101510019725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510019726 Coenzyme A binding pocket [chemical binding]; other site 101510019727 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 101510019728 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 101510019729 ferredoxin-NADP+ reductase; Region: PLN02852 101510019730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510019731 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 101510019732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510019733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510019734 Hemerythrin-like domain; Region: Hr-like; cd12108 101510019735 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 101510019736 active site 101510019737 Zn binding site [ion binding]; other site 101510019738 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510019739 active site 101510019740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510019741 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 101510019742 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 101510019743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510019744 putative substrate translocation pore; other site 101510019745 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 101510019746 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510019747 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510019748 Acyl CoA binding protein; Region: ACBP; pfam00887 101510019749 acyl-CoA binding pocket [chemical binding]; other site 101510019750 CoA binding site [chemical binding]; other site 101510019751 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 101510019752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510019753 S-adenosylmethionine binding site [chemical binding]; other site 101510019754 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510019755 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510019756 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 101510019757 putative hydrophobic ligand binding site [chemical binding]; other site 101510019758 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 101510019759 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 101510019760 conserved cys residue [active] 101510019761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510019762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 101510019763 Zn2+ binding site [ion binding]; other site 101510019764 Mg2+ binding site [ion binding]; other site 101510019765 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 101510019766 Uncharacterized conserved protein [Function unknown]; Region: COG2128 101510019767 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510019768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510019769 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 101510019770 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 101510019771 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510019772 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510019773 FMN-binding pocket [chemical binding]; other site 101510019774 flavin binding motif; other site 101510019775 phosphate binding motif [ion binding]; other site 101510019776 beta-alpha-beta structure motif; other site 101510019777 NAD binding pocket [chemical binding]; other site 101510019778 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510019779 catalytic loop [active] 101510019780 iron binding site [ion binding]; other site 101510019781 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 101510019782 putative hydrophobic ligand binding site [chemical binding]; other site 101510019783 protein interface [polypeptide binding]; other site 101510019784 gate; other site 101510019785 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510019786 short chain dehydrogenase; Provisional; Region: PRK05872 101510019787 classical (c) SDRs; Region: SDR_c; cd05233 101510019788 NAD(P) binding site [chemical binding]; other site 101510019789 active site 101510019790 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 101510019791 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 101510019792 acyl-activating enzyme (AAE) consensus motif; other site 101510019793 putative AMP binding site [chemical binding]; other site 101510019794 putative active site [active] 101510019795 putative CoA binding site [chemical binding]; other site 101510019796 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510019797 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510019798 active site 101510019799 Phosphotransferase enzyme family; Region: APH; pfam01636 101510019800 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 101510019801 homotrimer interaction site [polypeptide binding]; other site 101510019802 putative active site [active] 101510019803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510019804 Radical SAM superfamily; Region: Radical_SAM; pfam04055 101510019805 FeS/SAM binding site; other site 101510019806 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 101510019807 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 101510019808 hydrophobic ligand binding site; other site 101510019809 Helix-turn-helix domain; Region: HTH_20; pfam12840 101510019810 putative DNA binding site [nucleotide binding]; other site 101510019811 putative Zn2+ binding site [ion binding]; other site 101510019812 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 101510019813 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 101510019814 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 101510019815 dimer interface [polypeptide binding]; other site 101510019816 anticodon binding site; other site 101510019817 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 101510019818 homodimer interface [polypeptide binding]; other site 101510019819 motif 1; other site 101510019820 active site 101510019821 motif 2; other site 101510019822 GAD domain; Region: GAD; pfam02938 101510019823 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 101510019824 active site 101510019825 motif 3; other site 101510019826 Domain of unknown function (DUF389); Region: DUF389; cl00781 101510019827 Domain of unknown function (DUF389); Region: DUF389; pfam04087 101510019828 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 101510019829 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 101510019830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 101510019831 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 101510019832 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 101510019833 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 101510019834 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 101510019835 active site 101510019836 ATP binding site [chemical binding]; other site 101510019837 substrate binding site [chemical binding]; other site 101510019838 recombination factor protein RarA; Reviewed; Region: PRK13342 101510019839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510019840 Walker A motif; other site 101510019841 ATP binding site [chemical binding]; other site 101510019842 Walker B motif; other site 101510019843 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 101510019844 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 101510019845 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 101510019846 motif 1; other site 101510019847 active site 101510019848 motif 2; other site 101510019849 motif 3; other site 101510019850 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 101510019851 DHHA1 domain; Region: DHHA1; pfam02272 101510019852 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 101510019853 YceG-like family; Region: YceG; pfam02618 101510019854 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 101510019855 dimerization interface [polypeptide binding]; other site 101510019856 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 101510019857 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 101510019858 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 101510019859 NAD(P) binding site [chemical binding]; other site 101510019860 shikimate binding site; other site 101510019861 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 101510019862 chorismate synthase; Validated; Region: PRK05382 101510019863 Tetramer interface [polypeptide binding]; other site 101510019864 active site 101510019865 FMN-binding site [chemical binding]; other site 101510019866 shikimate kinase; Reviewed; Region: aroK; PRK00131 101510019867 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 101510019868 ADP binding site [chemical binding]; other site 101510019869 magnesium binding site [ion binding]; other site 101510019870 putative shikimate binding site; other site 101510019871 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 101510019872 active site 101510019873 dimer interface [polypeptide binding]; other site 101510019874 metal binding site [ion binding]; metal-binding site 101510019875 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 101510019876 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 101510019877 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 101510019878 active site 101510019879 elongation factor P; Validated; Region: PRK00529 101510019880 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 101510019881 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 101510019882 RNA binding site [nucleotide binding]; other site 101510019883 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 101510019884 RNA binding site [nucleotide binding]; other site 101510019885 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 101510019886 putative RNA binding site [nucleotide binding]; other site 101510019887 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 101510019888 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 101510019889 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 101510019890 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 101510019891 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 101510019892 dihydroorotase; Validated; Region: pyrC; PRK09357 101510019893 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510019894 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 101510019895 active site 101510019896 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 101510019897 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 101510019898 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 101510019899 catalytic site [active] 101510019900 subunit interface [polypeptide binding]; other site 101510019901 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 101510019902 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510019903 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510019904 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 101510019905 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510019906 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510019907 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 101510019908 IMP binding site; other site 101510019909 dimer interface [polypeptide binding]; other site 101510019910 interdomain contacts; other site 101510019911 partial ornithine binding site; other site 101510019912 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 101510019913 active site 101510019914 dimer interface [polypeptide binding]; other site 101510019915 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 101510019916 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 101510019917 catalytic site [active] 101510019918 G-X2-G-X-G-K; other site 101510019919 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 101510019920 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 101510019921 Flavoprotein; Region: Flavoprotein; pfam02441 101510019922 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 101510019923 S-adenosylmethionine synthetase; Validated; Region: PRK05250 101510019924 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 101510019925 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 101510019926 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 101510019927 primosome assembly protein PriA; Provisional; Region: PRK14873 101510019928 hypothetical protein; Provisional; Region: PRK06834 101510019929 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510019930 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510019931 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510019932 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 101510019933 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 101510019934 Lipase (class 2); Region: Lipase_2; pfam01674 101510019935 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 101510019936 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 101510019937 putative active site [active] 101510019938 substrate binding site [chemical binding]; other site 101510019939 putative cosubstrate binding site; other site 101510019940 catalytic site [active] 101510019941 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 101510019942 substrate binding site [chemical binding]; other site 101510019943 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 101510019944 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 101510019945 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 101510019946 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510019947 classical (c) SDRs; Region: SDR_c; cd05233 101510019948 NAD(P) binding site [chemical binding]; other site 101510019949 active site 101510019950 Protein of unknown function (DUF419); Region: DUF419; pfam04237 101510019951 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 101510019952 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 101510019953 substrate binding site [chemical binding]; other site 101510019954 hexamer interface [polypeptide binding]; other site 101510019955 metal binding site [ion binding]; metal-binding site 101510019956 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 101510019957 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 101510019958 catalytic motif [active] 101510019959 Zn binding site [ion binding]; other site 101510019960 RibD C-terminal domain; Region: RibD_C; pfam01872 101510019961 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 101510019962 Lumazine binding domain; Region: Lum_binding; pfam00677 101510019963 Lumazine binding domain; Region: Lum_binding; pfam00677 101510019964 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 101510019965 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 101510019966 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 101510019967 dimerization interface [polypeptide binding]; other site 101510019968 active site 101510019969 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 101510019970 homopentamer interface [polypeptide binding]; other site 101510019971 active site 101510019972 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 101510019973 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 101510019974 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 101510019975 GIY-YIG motif/motif A; other site 101510019976 active site 101510019977 catalytic site [active] 101510019978 putative DNA binding site [nucleotide binding]; other site 101510019979 metal binding site [ion binding]; metal-binding site 101510019980 UvrB/uvrC motif; Region: UVR; pfam02151 101510019981 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 101510019982 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 101510019983 minor groove reading motif; other site 101510019984 helix-hairpin-helix signature motif; other site 101510019985 active site 101510019986 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 101510019987 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 101510019988 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 101510019989 phosphate binding site [ion binding]; other site 101510019990 putative substrate binding pocket [chemical binding]; other site 101510019991 dimer interface [polypeptide binding]; other site 101510019992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 101510019993 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 101510019994 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 101510019995 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 101510019996 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 101510019997 Phosphoglycerate kinase; Region: PGK; pfam00162 101510019998 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 101510019999 substrate binding site [chemical binding]; other site 101510020000 hinge regions; other site 101510020001 ADP binding site [chemical binding]; other site 101510020002 catalytic site [active] 101510020003 triosephosphate isomerase; Provisional; Region: PRK14567 101510020004 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 101510020005 substrate binding site [chemical binding]; other site 101510020006 dimer interface [polypeptide binding]; other site 101510020007 catalytic triad [active] 101510020008 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 101510020009 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 101510020010 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 101510020011 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 101510020012 putative active site [active] 101510020013 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 101510020014 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 101510020015 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 101510020016 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 101510020017 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 101510020018 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 101510020019 putative active site [active] 101510020020 transaldolase; Provisional; Region: PRK03903 101510020021 catalytic residue [active] 101510020022 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 101510020023 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 101510020024 TPP-binding site [chemical binding]; other site 101510020025 dimer interface [polypeptide binding]; other site 101510020026 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 101510020027 PYR/PP interface [polypeptide binding]; other site 101510020028 dimer interface [polypeptide binding]; other site 101510020029 TPP binding site [chemical binding]; other site 101510020030 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510020031 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 101510020032 UbiA prenyltransferase family; Region: UbiA; pfam01040 101510020033 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 101510020034 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 101510020035 NADP binding site [chemical binding]; other site 101510020036 dimer interface [polypeptide binding]; other site 101510020037 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 101510020038 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 101510020039 ABC-2 type transporter; Region: ABC2_membrane; cl17235 101510020040 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 101510020041 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 101510020042 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 101510020043 Walker A/P-loop; other site 101510020044 ATP binding site [chemical binding]; other site 101510020045 Q-loop/lid; other site 101510020046 ABC transporter signature motif; other site 101510020047 Walker B; other site 101510020048 D-loop; other site 101510020049 H-loop/switch region; other site 101510020050 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 101510020051 Predicted transcriptional regulator [Transcription]; Region: COG2345 101510020052 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510020053 putative DNA binding site [nucleotide binding]; other site 101510020054 putative Zn2+ binding site [ion binding]; other site 101510020055 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 101510020056 FeS assembly protein SufB; Region: sufB; TIGR01980 101510020057 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 101510020058 FeS assembly protein SufD; Region: sufD; TIGR01981 101510020059 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 101510020060 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 101510020061 Walker A/P-loop; other site 101510020062 ATP binding site [chemical binding]; other site 101510020063 Q-loop/lid; other site 101510020064 ABC transporter signature motif; other site 101510020065 Walker B; other site 101510020066 D-loop; other site 101510020067 H-loop/switch region; other site 101510020068 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 101510020069 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 101510020070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510020071 catalytic residue [active] 101510020072 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 101510020073 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 101510020074 trimerization site [polypeptide binding]; other site 101510020075 active site 101510020076 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 101510020077 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 101510020078 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 101510020079 putative DNA binding site [nucleotide binding]; other site 101510020080 putative homodimer interface [polypeptide binding]; other site 101510020081 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 101510020082 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 101510020083 NAD binding site [chemical binding]; other site 101510020084 lycopene cyclase; Region: lycopene_cycl; TIGR01789 101510020085 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 101510020086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510020087 Walker A/P-loop; other site 101510020088 ATP binding site [chemical binding]; other site 101510020089 Q-loop/lid; other site 101510020090 ABC transporter signature motif; other site 101510020091 Walker B; other site 101510020092 D-loop; other site 101510020093 H-loop/switch region; other site 101510020094 ABC transporter; Region: ABC_tran_2; pfam12848 101510020095 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 101510020096 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 101510020097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510020098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510020099 aconitate hydratase; Validated; Region: PRK09277 101510020100 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 101510020101 substrate binding site [chemical binding]; other site 101510020102 ligand binding site [chemical binding]; other site 101510020103 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 101510020104 substrate binding site [chemical binding]; other site 101510020105 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510020106 NlpC/P60 family; Region: NLPC_P60; pfam00877 101510020107 MoxR-like ATPases [General function prediction only]; Region: COG0714 101510020108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510020109 Walker A motif; other site 101510020110 ATP binding site [chemical binding]; other site 101510020111 Walker B motif; other site 101510020112 arginine finger; other site 101510020113 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 101510020114 Protein of unknown function DUF58; Region: DUF58; pfam01882 101510020115 hypothetical protein; Provisional; Region: PRK13685 101510020116 Aerotolerance regulator N-terminal; Region: BatA; cl06567 101510020117 von Willebrand factor type A domain; Region: VWA_2; pfam13519 101510020118 metal ion-dependent adhesion site (MIDAS); other site 101510020119 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 101510020120 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 101510020121 NAD(P) binding site [chemical binding]; other site 101510020122 homotetramer interface [polypeptide binding]; other site 101510020123 homodimer interface [polypeptide binding]; other site 101510020124 active site 101510020125 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 101510020126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510020127 NAD(P) binding site [chemical binding]; other site 101510020128 active site 101510020129 ferrochelatase; Reviewed; Region: hemH; PRK00035 101510020130 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 101510020131 C-terminal domain interface [polypeptide binding]; other site 101510020132 active site 101510020133 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 101510020134 active site 101510020135 N-terminal domain interface [polypeptide binding]; other site 101510020136 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 101510020137 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 101510020138 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 101510020139 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 101510020140 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 101510020141 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510020142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510020143 catalytic residue [active] 101510020144 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510020145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510020146 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510020147 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 101510020148 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 101510020149 Uncharacterized conserved protein [Function unknown]; Region: COG0398 101510020150 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 101510020151 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 101510020152 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 101510020153 heterodimer interface [polypeptide binding]; other site 101510020154 substrate interaction site [chemical binding]; other site 101510020155 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 101510020156 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 101510020157 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 101510020158 active site 101510020159 substrate binding site [chemical binding]; other site 101510020160 coenzyme B12 binding site [chemical binding]; other site 101510020161 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 101510020162 B12 binding site [chemical binding]; other site 101510020163 cobalt ligand [ion binding]; other site 101510020164 membrane ATPase/protein kinase; Provisional; Region: PRK09435 101510020165 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 101510020166 GTP/Mg2+ binding site [chemical binding]; other site 101510020167 G5 box; other site 101510020168 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 101510020169 Walker A; other site 101510020170 G1 box; other site 101510020171 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 101510020172 active site 101510020173 OsmC-like protein; Region: OsmC; cl00767 101510020174 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 101510020175 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 101510020176 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510020177 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510020178 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 101510020179 Domain of unknown function DUF21; Region: DUF21; pfam01595 101510020180 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 101510020181 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 101510020182 Domain of unknown function DUF21; Region: DUF21; pfam01595 101510020183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 101510020184 Transporter associated domain; Region: CorC_HlyC; smart01091 101510020185 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 101510020186 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510020187 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 101510020188 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 101510020189 active site 101510020190 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 101510020191 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 101510020192 ATP binding site [chemical binding]; other site 101510020193 Mg++ binding site [ion binding]; other site 101510020194 motif III; other site 101510020195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510020196 nucleotide binding region [chemical binding]; other site 101510020197 ATP-binding site [chemical binding]; other site 101510020198 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510020199 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 101510020200 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 101510020201 helicase 45; Provisional; Region: PTZ00424 101510020202 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 101510020203 ATP binding site [chemical binding]; other site 101510020204 Mg++ binding site [ion binding]; other site 101510020205 motif III; other site 101510020206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 101510020207 nucleotide binding region [chemical binding]; other site 101510020208 ATP-binding site [chemical binding]; other site 101510020209 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 101510020210 Predicted transcriptional regulator [Transcription]; Region: COG3682 101510020211 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 101510020212 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 101510020213 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 101510020214 Walker A/P-loop; other site 101510020215 ATP binding site [chemical binding]; other site 101510020216 Q-loop/lid; other site 101510020217 ABC transporter signature motif; other site 101510020218 Walker B; other site 101510020219 D-loop; other site 101510020220 H-loop/switch region; other site 101510020221 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 101510020222 ABC-ATPase subunit interface; other site 101510020223 dimer interface [polypeptide binding]; other site 101510020224 putative PBP binding regions; other site 101510020225 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 101510020226 dimer interface [polypeptide binding]; other site 101510020227 putative PBP binding regions; other site 101510020228 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 101510020229 ABC-ATPase subunit interface; other site 101510020230 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510020231 CoenzymeA binding site [chemical binding]; other site 101510020232 subunit interaction site [polypeptide binding]; other site 101510020233 PHB binding site; other site 101510020234 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510020235 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510020236 Transposase IS200 like; Region: Y1_Tnp; pfam01797 101510020237 Probable transposase; Region: OrfB_IS605; pfam01385 101510020238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 101510020239 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 101510020240 AzlC protein; Region: AzlC; pfam03591 101510020241 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510020242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510020243 non-specific DNA binding site [nucleotide binding]; other site 101510020244 salt bridge; other site 101510020245 sequence-specific DNA binding site [nucleotide binding]; other site 101510020246 Cupin domain; Region: Cupin_2; cl17218 101510020247 YCII-related domain; Region: YCII; cl00999 101510020248 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 101510020249 Fic family protein [Function unknown]; Region: COG3177 101510020250 Fic/DOC family; Region: Fic; pfam02661 101510020251 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 101510020252 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 101510020253 ABC-ATPase subunit interface; other site 101510020254 dimer interface [polypeptide binding]; other site 101510020255 putative PBP binding regions; other site 101510020256 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 101510020257 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 101510020258 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 101510020259 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 101510020260 metal binding site [ion binding]; metal-binding site 101510020261 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 101510020262 hypothetical protein; Provisional; Region: PRK07236 101510020263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510020264 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510020265 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 101510020266 AsnC family; Region: AsnC_trans_reg; pfam01037 101510020267 AAA ATPase domain; Region: AAA_16; pfam13191 101510020268 AAA domain; Region: AAA_22; pfam13401 101510020269 Integrase core domain; Region: rve; pfam00665 101510020270 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 101510020271 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510020272 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510020273 classical (c) SDRs; Region: SDR_c; cd05233 101510020274 NAD(P) binding site [chemical binding]; other site 101510020275 active site 101510020276 Fic family protein [Function unknown]; Region: COG3177 101510020277 Fic/DOC family; Region: Fic; cl00960 101510020278 PemK-like protein; Region: PemK; pfam02452 101510020279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510020280 Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877 101510020281 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510020282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510020283 dimerization interface [polypeptide binding]; other site 101510020284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510020285 dimer interface [polypeptide binding]; other site 101510020286 phosphorylation site [posttranslational modification] 101510020287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510020288 ATP binding site [chemical binding]; other site 101510020289 Mg2+ binding site [ion binding]; other site 101510020290 G-X-G motif; other site 101510020291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510020292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510020293 active site 101510020294 phosphorylation site [posttranslational modification] 101510020295 intermolecular recognition site; other site 101510020296 dimerization interface [polypeptide binding]; other site 101510020297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510020298 DNA binding site [nucleotide binding] 101510020299 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510020300 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510020301 TIGR03118 family protein; Region: PEPCTERM_chp_1 101510020302 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510020303 AMP-binding enzyme; Region: AMP-binding; pfam00501 101510020304 acyl-activating enzyme (AAE) consensus motif; other site 101510020305 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510020306 CoA binding site [chemical binding]; other site 101510020307 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 101510020308 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510020309 NAD binding site [chemical binding]; other site 101510020310 catalytic residues [active] 101510020311 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510020312 Homeodomain-like domain; Region: HTH_23; cl17451 101510020313 Winged helix-turn helix; Region: HTH_29; pfam13551 101510020314 Homeodomain-like domain; Region: HTH_32; pfam13565 101510020315 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 101510020316 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 101510020317 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 101510020318 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 101510020319 putative active site [active] 101510020320 putative NTP binding site [chemical binding]; other site 101510020321 putative nucleic acid binding site [nucleotide binding]; other site 101510020322 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 101510020323 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 101510020324 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510020325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510020326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510020327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 101510020328 ATP binding site [chemical binding]; other site 101510020329 Walker A motif; other site 101510020330 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 101510020331 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510020332 putative active site [active] 101510020333 ATP binding site [chemical binding]; other site 101510020334 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510020335 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510020336 FMN-binding pocket [chemical binding]; other site 101510020337 flavin binding motif; other site 101510020338 phosphate binding motif [ion binding]; other site 101510020339 beta-alpha-beta structure motif; other site 101510020340 NAD binding pocket [chemical binding]; other site 101510020341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510020342 catalytic loop [active] 101510020343 iron binding site [ion binding]; other site 101510020344 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510020345 substrate binding site [chemical binding]; other site 101510020346 oxyanion hole (OAH) forming residues; other site 101510020347 trimer interface [polypeptide binding]; other site 101510020348 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 101510020349 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 101510020350 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 101510020351 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510020352 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510020353 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 101510020354 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510020355 NAD(P) binding site [chemical binding]; other site 101510020356 Domain of unknown function (DUF427); Region: DUF427; pfam04248 101510020357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 101510020358 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510020359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510020360 substrate binding site [chemical binding]; other site 101510020361 oxyanion hole (OAH) forming residues; other site 101510020362 trimer interface [polypeptide binding]; other site 101510020363 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510020364 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510020365 acyl-activating enzyme (AAE) consensus motif; other site 101510020366 AMP binding site [chemical binding]; other site 101510020367 active site 101510020368 CoA binding site [chemical binding]; other site 101510020369 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510020370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510020371 active site 101510020372 phosphorylation site [posttranslational modification] 101510020373 intermolecular recognition site; other site 101510020374 dimerization interface [polypeptide binding]; other site 101510020375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510020376 DNA binding residues [nucleotide binding] 101510020377 dimerization interface [polypeptide binding]; other site 101510020378 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 101510020379 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510020380 active site 101510020381 ATP binding site [chemical binding]; other site 101510020382 substrate binding site [chemical binding]; other site 101510020383 activation loop (A-loop); other site 101510020384 AAA ATPase domain; Region: AAA_16; pfam13191 101510020385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510020386 Histidine kinase; Region: HisKA_3; pfam07730 101510020387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510020388 ATP binding site [chemical binding]; other site 101510020389 Mg2+ binding site [ion binding]; other site 101510020390 G-X-G motif; other site 101510020391 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 101510020392 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 101510020393 NAD binding site [chemical binding]; other site 101510020394 active site 101510020395 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 101510020396 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 101510020397 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 101510020398 active site 101510020399 Fe binding site [ion binding]; other site 101510020400 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510020401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510020402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510020403 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 101510020404 [2Fe-2S] cluster binding site [ion binding]; other site 101510020405 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 101510020406 inter-subunit interface; other site 101510020407 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510020408 Rieske non-heme iron oxygenase (RO) family, Biphenyl dioxygenase (BPDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of BPDO and similar proteins including cumene dioxygenase (CumDO); Region: Rieske_RO_Alpha_BPDO_like; cd03472 101510020409 beta subunit interaction site [polypeptide binding]; other site 101510020410 alpha subunit interaction site [polypeptide binding]; other site 101510020411 iron-sulfur cluster [ion binding]; other site 101510020412 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 101510020413 beta subunit interface [polypeptide binding]; other site 101510020414 alpha subunit interface [polypeptide binding]; other site 101510020415 active site 101510020416 substrate binding site [chemical binding]; other site 101510020417 Fe binding site [ion binding]; other site 101510020418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510020419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510020420 ATP binding site [chemical binding]; other site 101510020421 Mg2+ binding site [ion binding]; other site 101510020422 G-X-G motif; other site 101510020423 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510020424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510020425 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 101510020426 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510020427 DNA binding residues [nucleotide binding] 101510020428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510020429 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510020430 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510020431 FMN-binding pocket [chemical binding]; other site 101510020432 flavin binding motif; other site 101510020433 phosphate binding motif [ion binding]; other site 101510020434 beta-alpha-beta structure motif; other site 101510020435 NAD binding pocket [chemical binding]; other site 101510020436 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510020437 catalytic loop [active] 101510020438 iron binding site [ion binding]; other site 101510020439 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510020440 Cytochrome P450; Region: p450; cl12078 101510020441 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 101510020442 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 101510020443 active site 101510020444 EthD domain; Region: EthD; cl17553 101510020445 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 101510020446 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510020447 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510020448 active site 101510020449 ATP binding site [chemical binding]; other site 101510020450 substrate binding site [chemical binding]; other site 101510020451 activation loop (A-loop); other site 101510020452 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510020453 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 101510020454 AAA ATPase domain; Region: AAA_16; pfam13191 101510020455 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510020456 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 101510020457 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 101510020458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510020459 catalytic loop [active] 101510020460 iron binding site [ion binding]; other site 101510020461 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 101510020462 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 101510020463 tetramer interface [polypeptide binding]; other site 101510020464 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 101510020465 tetramer interface [polypeptide binding]; other site 101510020466 active site 101510020467 Fe binding site [ion binding]; other site 101510020468 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 101510020469 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 101510020470 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510020471 Transcription factor WhiB; Region: Whib; pfam02467 101510020472 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 101510020473 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 101510020474 active site 101510020475 catalytic residues [active] 101510020476 metal binding site [ion binding]; metal-binding site 101510020477 DmpG-like communication domain; Region: DmpG_comm; pfam07836 101510020478 acetaldehyde dehydrogenase; Validated; Region: PRK08300 101510020479 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510020480 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 101510020481 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 101510020482 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510020483 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510020484 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510020485 GAF domain; Region: GAF; pfam01590 101510020486 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510020487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510020488 DNA binding residues [nucleotide binding] 101510020489 dimerization interface [polypeptide binding]; other site 101510020490 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510020491 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510020492 NAD(P) binding site [chemical binding]; other site 101510020493 catalytic residues [active] 101510020494 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 101510020495 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 101510020496 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 101510020497 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 101510020498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510020499 DNA-binding site [nucleotide binding]; DNA binding site 101510020500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510020501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510020502 homodimer interface [polypeptide binding]; other site 101510020503 catalytic residue [active] 101510020504 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 101510020505 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 101510020506 Cupin domain; Region: Cupin_2; cl17218 101510020507 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 101510020508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510020509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510020510 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 101510020511 Cellulose synthase-like protein; Region: PLN02893 101510020512 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 101510020513 homodimer interface [polypeptide binding]; other site 101510020514 putative active site [active] 101510020515 catalytic site [active] 101510020516 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510020517 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 101510020518 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 101510020519 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510020520 active site 101510020521 catalytic residues [active] 101510020522 DNA binding site [nucleotide binding] 101510020523 Int/Topo IB signature motif; other site 101510020524 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 101510020525 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510020526 DNA binding residues [nucleotide binding] 101510020527 Lsr2; Region: Lsr2; pfam11774 101510020528 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 101510020529 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510020530 Uncharacterized conserved protein [Function unknown]; Region: COG3268 101510020531 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 101510020532 catalytic residue [active] 101510020533 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 101510020534 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510020535 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510020536 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510020537 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 101510020538 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 101510020539 active site 101510020540 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 101510020541 active site 101510020542 catalytic triad [active] 101510020543 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 101510020544 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 101510020545 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 101510020546 active site 101510020547 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510020548 Secretory lipase; Region: LIP; pfam03583 101510020549 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 101510020550 Lipase (class 2); Region: Lipase_2; pfam01674 101510020551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510020552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510020553 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510020554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510020555 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510020556 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510020557 active site 101510020558 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510020559 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 101510020560 dimer interface [polypeptide binding]; other site 101510020561 acyl-activating enzyme (AAE) consensus motif; other site 101510020562 putative active site [active] 101510020563 AMP binding site [chemical binding]; other site 101510020564 putative CoA binding site [chemical binding]; other site 101510020565 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 101510020566 Strictosidine synthase; Region: Str_synth; pfam03088 101510020567 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 101510020568 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510020569 FMN binding site [chemical binding]; other site 101510020570 substrate binding site [chemical binding]; other site 101510020571 putative catalytic residue [active] 101510020572 enoyl-CoA hydratase; Provisional; Region: PRK08260 101510020573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510020574 substrate binding site [chemical binding]; other site 101510020575 oxyanion hole (OAH) forming residues; other site 101510020576 trimer interface [polypeptide binding]; other site 101510020577 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510020578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510020579 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 101510020580 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 101510020581 dimer interface [polypeptide binding]; other site 101510020582 NADP binding site [chemical binding]; other site 101510020583 catalytic residues [active] 101510020584 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510020585 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510020586 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510020587 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510020588 active site 101510020589 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510020590 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510020591 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 101510020592 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510020593 catalytic Zn binding site [ion binding]; other site 101510020594 structural Zn binding site [ion binding]; other site 101510020595 tetramer interface [polypeptide binding]; other site 101510020596 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 101510020597 Histidine kinase; Region: HisKA_3; pfam07730 101510020598 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510020599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510020600 active site 101510020601 phosphorylation site [posttranslational modification] 101510020602 intermolecular recognition site; other site 101510020603 dimerization interface [polypeptide binding]; other site 101510020604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510020605 DNA binding residues [nucleotide binding] 101510020606 dimerization interface [polypeptide binding]; other site 101510020607 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510020608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510020609 putative substrate translocation pore; other site 101510020610 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510020611 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 101510020612 intersubunit interface [polypeptide binding]; other site 101510020613 active site 101510020614 Zn2+ binding site [ion binding]; other site 101510020615 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510020616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510020617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510020618 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 101510020619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510020620 NAD(P) binding site [chemical binding]; other site 101510020621 active site 101510020622 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 101510020623 inter-subunit interface; other site 101510020624 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510020625 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 101510020626 alpha subunit interaction site [polypeptide binding]; other site 101510020627 beta subunit interaction site [polypeptide binding]; other site 101510020628 iron-sulfur cluster [ion binding]; other site 101510020629 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 101510020630 beta subunit interface [polypeptide binding]; other site 101510020631 alpha subunit interface [polypeptide binding]; other site 101510020632 active site 101510020633 substrate binding site [chemical binding]; other site 101510020634 Fe binding site [ion binding]; other site 101510020635 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510020636 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510020637 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510020638 Isochorismatase family; Region: Isochorismatase; pfam00857 101510020639 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 101510020640 catalytic triad [active] 101510020641 substrate binding site [chemical binding]; other site 101510020642 domain interfaces; other site 101510020643 conserved cis-peptide bond; other site 101510020644 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510020645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510020646 dimer interface [polypeptide binding]; other site 101510020647 conserved gate region; other site 101510020648 putative PBP binding loops; other site 101510020649 ABC-ATPase subunit interface; other site 101510020650 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510020651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510020652 dimer interface [polypeptide binding]; other site 101510020653 conserved gate region; other site 101510020654 putative PBP binding loops; other site 101510020655 ABC-ATPase subunit interface; other site 101510020656 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510020657 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 101510020658 Walker A/P-loop; other site 101510020659 ATP binding site [chemical binding]; other site 101510020660 Q-loop/lid; other site 101510020661 ABC transporter signature motif; other site 101510020662 Walker B; other site 101510020663 D-loop; other site 101510020664 H-loop/switch region; other site 101510020665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 101510020666 NMT1/THI5 like; Region: NMT1; pfam09084 101510020667 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 101510020668 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510020669 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510020670 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510020671 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510020672 iron-sulfur cluster [ion binding]; other site 101510020673 [2Fe-2S] cluster binding site [ion binding]; other site 101510020674 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 101510020675 putative alpha subunit interface [polypeptide binding]; other site 101510020676 putative active site [active] 101510020677 putative substrate binding site [chemical binding]; other site 101510020678 Fe binding site [ion binding]; other site 101510020679 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 101510020680 inter-subunit interface; other site 101510020681 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 101510020682 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 101510020683 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 101510020684 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510020685 catalytic loop [active] 101510020686 iron binding site [ion binding]; other site 101510020687 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 101510020688 FAD binding pocket [chemical binding]; other site 101510020689 FAD binding motif [chemical binding]; other site 101510020690 phosphate binding motif [ion binding]; other site 101510020691 beta-alpha-beta structure motif; other site 101510020692 NAD binding pocket [chemical binding]; other site 101510020693 benzoate transport; Region: 2A0115; TIGR00895 101510020694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510020695 putative substrate translocation pore; other site 101510020696 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510020697 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510020698 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510020699 Helix-turn-helix domain; Region: HTH_38; pfam13936 101510020700 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 101510020701 Integrase core domain; Region: rve; pfam00665 101510020702 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510020703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510020704 hypothetical protein; Validated; Region: PRK07581 101510020705 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 101510020706 EthD domain; Region: EthD; cl17553 101510020707 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510020708 AMP binding site [chemical binding]; other site 101510020709 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510020710 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510020711 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 101510020712 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 101510020713 active site 101510020714 NTP binding site [chemical binding]; other site 101510020715 metal binding triad [ion binding]; metal-binding site 101510020716 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510020717 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510020718 acyl-activating enzyme (AAE) consensus motif; other site 101510020719 AMP binding site [chemical binding]; other site 101510020720 active site 101510020721 CoA binding site [chemical binding]; other site 101510020722 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 101510020723 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 101510020724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510020725 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 101510020726 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510020727 Excalibur calcium-binding domain; Region: Excalibur; smart00894 101510020728 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 101510020729 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510020730 putative metal binding site [ion binding]; other site 101510020731 hypothetical protein; Provisional; Region: PRK14013 101510020732 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 101510020733 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510020734 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 101510020735 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510020736 putative metal binding site [ion binding]; other site 101510020737 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510020738 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510020739 TM-ABC transporter signature motif; other site 101510020740 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510020741 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510020742 Walker A/P-loop; other site 101510020743 ATP binding site [chemical binding]; other site 101510020744 Q-loop/lid; other site 101510020745 ABC transporter signature motif; other site 101510020746 Walker B; other site 101510020747 D-loop; other site 101510020748 H-loop/switch region; other site 101510020749 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510020750 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 101510020751 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510020752 putative ligand binding site [chemical binding]; other site 101510020753 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 101510020754 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510020755 NAD binding site [chemical binding]; other site 101510020756 catalytic residues [active] 101510020757 MarR family; Region: MarR_2; cl17246 101510020758 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 101510020759 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 101510020760 nucleotide binding site [chemical binding]; other site 101510020761 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510020762 classical (c) SDRs; Region: SDR_c; cd05233 101510020763 NAD(P) binding site [chemical binding]; other site 101510020764 active site 101510020765 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510020766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510020767 putative substrate translocation pore; other site 101510020768 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 101510020769 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 101510020770 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 101510020771 hypothetical protein; Provisional; Region: PRK02399 101510020772 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 101510020773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510020774 classical (c) SDRs; Region: SDR_c; cd05233 101510020775 NAD(P) binding site [chemical binding]; other site 101510020776 active site 101510020777 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 101510020778 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 101510020779 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 101510020780 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 101510020781 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 101510020782 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 101510020783 Ligand Binding Site [chemical binding]; other site 101510020784 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 101510020785 Lsr2; Region: Lsr2; pfam11774 101510020786 Lsr2; Region: Lsr2; pfam11774 101510020787 Lsr2; Region: Lsr2; pfam11774 101510020788 Lsr2; Region: Lsr2; pfam11774 101510020789 Transcription factor WhiB; Region: Whib; pfam02467 101510020790 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 101510020791 Transposase; Region: DDE_Tnp_ISL3; pfam01610 101510020792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510020793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510020794 putative substrate translocation pore; other site 101510020795 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510020796 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510020797 FOG: CBS domain [General function prediction only]; Region: COG0517 101510020798 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 101510020799 BON domain; Region: BON; cl02771 101510020800 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 101510020801 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 101510020802 dimerization interface [polypeptide binding]; other site 101510020803 DPS ferroxidase diiron center [ion binding]; other site 101510020804 ion pore; other site 101510020805 Transcription factor WhiB; Region: Whib; pfam02467 101510020806 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 101510020807 ligand binding site [chemical binding]; other site 101510020808 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510020809 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510020810 phosphopeptide binding site; other site 101510020811 Predicted transcriptional regulator [Transcription]; Region: COG2345 101510020812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510020813 putative DNA binding site [nucleotide binding]; other site 101510020814 putative Zn2+ binding site [ion binding]; other site 101510020815 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 101510020816 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 101510020817 tetramer interface [polypeptide binding]; other site 101510020818 heme binding pocket [chemical binding]; other site 101510020819 NADPH binding site [chemical binding]; other site 101510020820 YCII-related domain; Region: YCII; cl00999 101510020821 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510020822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510020823 active site 101510020824 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 101510020825 aconitate hydratase; Validated; Region: PRK09277 101510020826 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 101510020827 substrate binding site [chemical binding]; other site 101510020828 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 101510020829 ligand binding site [chemical binding]; other site 101510020830 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 101510020831 substrate binding site [chemical binding]; other site 101510020832 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 101510020833 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 101510020834 Protein of unknown function, DUF488; Region: DUF488; cl01246 101510020835 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 101510020836 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 101510020837 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 101510020838 Transcriptional regulators [Transcription]; Region: MarR; COG1846 101510020839 MarR family; Region: MarR_2; pfam12802 101510020840 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 101510020841 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 101510020842 active site 101510020843 FMN binding site [chemical binding]; other site 101510020844 substrate binding site [chemical binding]; other site 101510020845 3Fe-4S cluster binding site [ion binding]; other site 101510020846 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510020847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510020848 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 101510020849 putative active site [active] 101510020850 transaldolase; Provisional; Region: PRK03903 101510020851 catalytic residue [active] 101510020852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510020853 dimerization interface [polypeptide binding]; other site 101510020854 putative DNA binding site [nucleotide binding]; other site 101510020855 Predicted transcriptional regulator [Transcription]; Region: COG2345 101510020856 putative Zn2+ binding site [ion binding]; other site 101510020857 GTP cyclohydrolase I; Provisional; Region: PLN03044 101510020858 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 101510020859 active site 101510020860 Protein of unknown function, DUF488; Region: DUF488; pfam04343 101510020861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510020862 dimerization interface [polypeptide binding]; other site 101510020863 putative DNA binding site [nucleotide binding]; other site 101510020864 Predicted transcriptional regulator [Transcription]; Region: COG2345 101510020865 putative Zn2+ binding site [ion binding]; other site 101510020866 Ferredoxin [Energy production and conversion]; Region: COG1146 101510020867 4Fe-4S binding domain; Region: Fer4; pfam00037 101510020868 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 101510020869 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 101510020870 D-pathway; other site 101510020871 Putative ubiquinol binding site [chemical binding]; other site 101510020872 Low-spin heme (heme b) binding site [chemical binding]; other site 101510020873 Putative water exit pathway; other site 101510020874 Binuclear center (heme o3/CuB) [ion binding]; other site 101510020875 K-pathway; other site 101510020876 Putative proton exit pathway; other site 101510020877 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 101510020878 heme-binding site [chemical binding]; other site 101510020879 Protein of unknown function (DUF952); Region: DUF952; pfam06108 101510020880 Predicted transcriptional regulator [Transcription]; Region: COG2345 101510020881 HTH domain; Region: HTH_11; cl17392 101510020882 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 101510020883 synthetase active site [active] 101510020884 NTP binding site [chemical binding]; other site 101510020885 metal binding site [ion binding]; metal-binding site 101510020886 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510020887 MarR family; Region: MarR; pfam01047 101510020888 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 101510020889 active site clefts [active] 101510020890 zinc binding site [ion binding]; other site 101510020891 dimer interface [polypeptide binding]; other site 101510020892 Amidase; Region: Amidase; cl11426 101510020893 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510020894 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 101510020895 Helix-turn-helix domain; Region: HTH_38; pfam13936 101510020896 Integrase core domain; Region: rve; pfam00665 101510020897 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510020898 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510020899 active site 101510020900 catalytic residues [active] 101510020901 DNA binding site [nucleotide binding] 101510020902 Int/Topo IB signature motif; other site 101510020903 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 101510020904 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510020905 active site 101510020906 Int/Topo IB signature motif; other site 101510020907 DNA binding site [nucleotide binding] 101510020908 MULE transposase domain; Region: MULE; pfam10551 101510020909 YCII-related domain; Region: YCII; cl00999 101510020910 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 101510020911 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 101510020912 active site 101510020913 FMN binding site [chemical binding]; other site 101510020914 substrate binding site [chemical binding]; other site 101510020915 3Fe-4S cluster binding site [ion binding]; other site 101510020916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510020917 MarR family; Region: MarR; pfam01047 101510020918 short chain dehydrogenase; Provisional; Region: PRK07109 101510020919 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 101510020920 putative NAD(P) binding site [chemical binding]; other site 101510020921 active site 101510020922 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 101510020923 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 101510020924 thiamine pyrophosphate protein; Provisional; Region: PRK08273 101510020925 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 101510020926 PYR/PP interface [polypeptide binding]; other site 101510020927 dimer interface [polypeptide binding]; other site 101510020928 tetramer interface [polypeptide binding]; other site 101510020929 TPP binding site [chemical binding]; other site 101510020930 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 101510020931 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 101510020932 TPP-binding site [chemical binding]; other site 101510020933 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 101510020934 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 101510020935 putative active site pocket [active] 101510020936 putative metal binding site [ion binding]; other site 101510020937 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510020938 FAD binding domain; Region: FAD_binding_4; pfam01565 101510020939 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 101510020940 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 101510020941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510020942 Protein of unknown function (DUF998); Region: DUF998; pfam06197 101510020943 Homeodomain-like domain; Region: HTH_23; pfam13384 101510020944 Winged helix-turn helix; Region: HTH_29; pfam13551 101510020945 Homeodomain-like domain; Region: HTH_32; pfam13565 101510020946 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510020947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510020948 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 101510020949 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510020950 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510020951 catalytic residue [active] 101510020952 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 101510020953 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 101510020954 active site 101510020955 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 101510020956 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 101510020957 nucleophile elbow; other site 101510020958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510020959 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510020960 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510020961 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 101510020962 RibD C-terminal domain; Region: RibD_C; cl17279 101510020963 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 101510020964 PhoU domain; Region: PhoU; pfam01895 101510020965 PhoU domain; Region: PhoU; pfam01895 101510020966 Protein of unknown function, DUF488; Region: DUF488; pfam04343 101510020967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510020968 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 101510020969 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 101510020970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 101510020971 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 101510020972 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 101510020973 anti sigma factor interaction site; other site 101510020974 regulatory phosphorylation site [posttranslational modification]; other site 101510020975 GAF domain; Region: GAF; cl17456 101510020976 ANTAR domain; Region: ANTAR; pfam03861 101510020977 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 101510020978 HSP70 interaction site [polypeptide binding]; other site 101510020979 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 101510020980 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 101510020981 putative dimer interface [polypeptide binding]; other site 101510020982 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 101510020983 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 101510020984 DNA binding residues [nucleotide binding] 101510020985 putative dimer interface [polypeptide binding]; other site 101510020986 Transcription factor WhiB; Region: Whib; pfam02467 101510020987 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 101510020988 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 101510020989 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 101510020990 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 101510020991 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 101510020992 putative dimer interface [polypeptide binding]; other site 101510020993 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510020994 S-formylglutathione hydrolase; Region: PLN02442 101510020995 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 101510020996 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 101510020997 nucleotide binding site [chemical binding]; other site 101510020998 NEF interaction site [polypeptide binding]; other site 101510020999 SBD interface [polypeptide binding]; other site 101510021000 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 101510021001 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 101510021002 dimer interface [polypeptide binding]; other site 101510021003 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 101510021004 chaperone protein DnaJ; Provisional; Region: PRK14279 101510021005 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 101510021006 HSP70 interaction site [polypeptide binding]; other site 101510021007 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 101510021008 Zn binding sites [ion binding]; other site 101510021009 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 101510021010 dimer interface [polypeptide binding]; other site 101510021011 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510021012 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510021013 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 101510021014 carboxylate-amine ligase; Provisional; Region: PRK13517 101510021015 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 101510021016 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 101510021017 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 101510021018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510021019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510021020 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510021021 NmrA-like family; Region: NmrA; pfam05368 101510021022 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 101510021023 NAD(P) binding site [chemical binding]; other site 101510021024 putative active site [active] 101510021025 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 101510021026 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 101510021027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 101510021028 Integrase core domain; Region: rve; pfam00665 101510021029 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 101510021030 Leucine carboxyl methyltransferase; Region: LCM; cl01306 101510021031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 101510021032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 101510021033 Coenzyme A binding pocket [chemical binding]; other site 101510021034 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 101510021035 Winged helix-turn helix; Region: HTH_29; pfam13551 101510021036 Integrase core domain; Region: rve; pfam00665 101510021037 Integrase core domain; Region: rve_3; pfam13683 101510021038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510021039 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510021040 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510021041 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510021042 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510021043 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 101510021044 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 101510021045 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 101510021046 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 101510021047 DDE superfamily endonuclease; Region: DDE_5; cl17874 101510021048 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 101510021049 catalytic residue [active] 101510021050 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 101510021051 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510021052 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510021053 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 101510021054 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 101510021055 active site 101510021056 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 101510021057 active site 101510021058 catalytic triad [active] 101510021059 chaperone protein DnaJ; Provisional; Region: PRK14279 101510021060 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 101510021061 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 101510021062 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 101510021063 active site 101510021064 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510021065 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510021066 Secretory lipase; Region: LIP; pfam03583 101510021067 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 101510021068 Lipase (class 2); Region: Lipase_2; pfam01674 101510021069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510021070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510021071 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510021072 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 101510021073 catalytic core [active] 101510021074 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510021075 Predicted ATPase [General function prediction only]; Region: COG3903 101510021076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510021077 DNA binding residues [nucleotide binding] 101510021078 dimerization interface [polypeptide binding]; other site 101510021079 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510021080 MULE transposase domain; Region: MULE; pfam10551 101510021081 AAA ATPase domain; Region: AAA_16; pfam13191 101510021082 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510021083 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 101510021084 NAD(P) binding site [chemical binding]; other site 101510021085 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510021086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510021087 active site 101510021088 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 101510021089 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 101510021090 acyl-activating enzyme (AAE) consensus motif; other site 101510021091 putative AMP binding site [chemical binding]; other site 101510021092 putative active site [active] 101510021093 putative CoA binding site [chemical binding]; other site 101510021094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510021095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510021096 TM-ABC transporter signature motif; other site 101510021097 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510021098 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510021099 Walker A/P-loop; other site 101510021100 ATP binding site [chemical binding]; other site 101510021101 Q-loop/lid; other site 101510021102 ABC transporter signature motif; other site 101510021103 Walker B; other site 101510021104 D-loop; other site 101510021105 H-loop/switch region; other site 101510021106 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510021107 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510021108 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 101510021109 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 101510021110 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 101510021111 active site 101510021112 dimer interface [polypeptide binding]; other site 101510021113 metal binding site [ion binding]; metal-binding site 101510021114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510021115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510021116 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510021117 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 101510021118 NAD(P) binding site [chemical binding]; other site 101510021119 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510021120 putative active site [active] 101510021121 putative substrate binding site [chemical binding]; other site 101510021122 ATP binding site [chemical binding]; other site 101510021123 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510021124 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 101510021125 active site 101510021126 catalytic site [active] 101510021127 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510021128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510021129 NAD(P) binding site [chemical binding]; other site 101510021130 active site 101510021131 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 101510021132 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 101510021133 NAD binding site [chemical binding]; other site 101510021134 homodimer interface [polypeptide binding]; other site 101510021135 homotetramer interface [polypeptide binding]; other site 101510021136 active site 101510021137 citrate synthase 2; Provisional; Region: PRK12350 101510021138 Citrate synthase; Region: Citrate_synt; pfam00285 101510021139 oxalacetate binding site [chemical binding]; other site 101510021140 citrylCoA binding site [chemical binding]; other site 101510021141 coenzyme A binding site [chemical binding]; other site 101510021142 catalytic triad [active] 101510021143 RibD C-terminal domain; Region: RibD_C; cl17279 101510021144 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 101510021145 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 101510021146 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 101510021147 metal binding site [ion binding]; metal-binding site 101510021148 dimer interface [polypeptide binding]; other site 101510021149 acyl-CoA synthetase; Validated; Region: PRK08162 101510021150 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 101510021151 acyl-activating enzyme (AAE) consensus motif; other site 101510021152 putative active site [active] 101510021153 AMP binding site [chemical binding]; other site 101510021154 putative CoA binding site [chemical binding]; other site 101510021155 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 101510021156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510021157 catalytic residue [active] 101510021158 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 101510021159 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 101510021160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510021161 catalytic residue [active] 101510021162 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 101510021163 ATP-NAD kinase; Region: NAD_kinase; pfam01513 101510021164 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510021165 classical (c) SDRs; Region: SDR_c; cd05233 101510021166 NAD(P) binding site [chemical binding]; other site 101510021167 active site 101510021168 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510021169 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 101510021170 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510021171 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510021172 dimerization interface [polypeptide binding]; other site 101510021173 substrate binding pocket [chemical binding]; other site 101510021174 ethanolamine permease; Region: 2A0305; TIGR00908 101510021175 tyramine oxidase; Provisional; Region: tynA; PRK11504 101510021176 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 101510021177 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 101510021178 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 101510021179 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510021180 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510021181 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 101510021182 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510021183 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 101510021184 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 101510021185 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 101510021186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510021187 active site 101510021188 DNA binding site [nucleotide binding] 101510021189 Int/Topo IB signature motif; other site 101510021190 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510021191 active site 101510021192 DNA binding site [nucleotide binding] 101510021193 Int/Topo IB signature motif; other site 101510021194 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 101510021195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510021196 active site 101510021197 DNA binding site [nucleotide binding] 101510021198 Int/Topo IB signature motif; other site 101510021199 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510021200 MULE transposase domain; Region: MULE; pfam10551 101510021201 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 101510021202 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 101510021203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 101510021204 DNA binding residues [nucleotide binding] 101510021205 Helicase associated domain; Region: HA; pfam03457 101510021206 Helicase associated domain; Region: HA; pfam03457 101510021207 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 101510021208 Winged helix-turn helix; Region: HTH_29; pfam13551 101510021209 Homeodomain-like domain; Region: HTH_32; pfam13565 101510021210 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510021211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510021212 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 101510021213 Transposase domain (DUF772); Region: DUF772; pfam05598 101510021214 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 101510021215 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510021216 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 101510021217 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 101510021218 DNA binding site [nucleotide binding] 101510021219 Uncharacterized conserved protein [Function unknown]; Region: COG2135 101510021220 Lsr2; Region: Lsr2; pfam11774 101510021221 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510021222 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510021223 classical (c) SDRs; Region: SDR_c; cd05233 101510021224 NAD(P) binding site [chemical binding]; other site 101510021225 active site 101510021226 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317 101510021227 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510021228 putative ligand binding site [chemical binding]; other site 101510021229 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510021230 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510021231 TM-ABC transporter signature motif; other site 101510021232 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 101510021233 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510021234 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510021235 TM-ABC transporter signature motif; other site 101510021236 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510021237 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510021238 Walker A/P-loop; other site 101510021239 ATP binding site [chemical binding]; other site 101510021240 Q-loop/lid; other site 101510021241 ABC transporter signature motif; other site 101510021242 Walker B; other site 101510021243 D-loop; other site 101510021244 H-loop/switch region; other site 101510021245 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510021246 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510021247 classical (c) SDRs; Region: SDR_c; cd05233 101510021248 NAD(P) binding site [chemical binding]; other site 101510021249 active site 101510021250 SnoaL-like domain; Region: SnoaL_3; pfam13474 101510021251 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510021252 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 101510021253 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 101510021254 active site 101510021255 dimer interface [polypeptide binding]; other site 101510021256 metal binding site [ion binding]; metal-binding site 101510021257 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 101510021258 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 101510021259 dimer interface [polypeptide binding]; other site 101510021260 active site 101510021261 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 101510021262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510021263 NAD(P) binding site [chemical binding]; other site 101510021264 active site 101510021265 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 101510021266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510021267 non-specific DNA binding site [nucleotide binding]; other site 101510021268 salt bridge; other site 101510021269 sequence-specific DNA binding site [nucleotide binding]; other site 101510021270 Cupin domain; Region: Cupin_2; pfam07883 101510021271 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 101510021272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021273 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 101510021274 PemK-like protein; Region: PemK; pfam02452 101510021275 NmrA-like family; Region: NmrA; pfam05368 101510021276 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 101510021277 NAD(P) binding site [chemical binding]; other site 101510021278 putative active site [active] 101510021279 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510021280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510021281 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 101510021282 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510021283 catalytic residues [active] 101510021284 catalytic nucleophile [active] 101510021285 Presynaptic Site I dimer interface [polypeptide binding]; other site 101510021286 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 101510021287 Synaptic Flat tetramer interface [polypeptide binding]; other site 101510021288 Synaptic Site I dimer interface [polypeptide binding]; other site 101510021289 DNA binding site [nucleotide binding] 101510021290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 101510021291 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510021292 transposase; Provisional; Region: PRK06526 101510021293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510021294 Walker A motif; other site 101510021295 ATP binding site [chemical binding]; other site 101510021296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 101510021297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 101510021298 DNA-binding site [nucleotide binding]; DNA binding site 101510021299 Integrase core domain; Region: rve; pfam00665 101510021300 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 101510021301 Integrase core domain; Region: rve; pfam00665 101510021302 Helix-turn-helix domain; Region: HTH_38; pfam13936 101510021303 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 101510021304 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510021305 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 101510021306 active site 101510021307 FMN binding site [chemical binding]; other site 101510021308 substrate binding site [chemical binding]; other site 101510021309 putative catalytic residue [active] 101510021310 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 101510021311 active site 101510021312 catalytic site [active] 101510021313 NHL repeat; Region: NHL; pfam01436 101510021314 NHL repeat; Region: NHL; pfam01436 101510021315 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510021316 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510021317 phosphopeptide binding site; other site 101510021318 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510021319 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510021320 phosphopeptide binding site; other site 101510021321 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 101510021322 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 101510021323 Walker A/P-loop; other site 101510021324 ATP binding site [chemical binding]; other site 101510021325 Q-loop/lid; other site 101510021326 ABC transporter signature motif; other site 101510021327 Walker B; other site 101510021328 D-loop; other site 101510021329 H-loop/switch region; other site 101510021330 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 101510021331 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 101510021332 Acyl CoA binding protein; Region: ACBP; pfam00887 101510021333 acyl-CoA binding pocket [chemical binding]; other site 101510021334 CoA binding site [chemical binding]; other site 101510021335 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510021336 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510021337 active site 101510021338 ATP binding site [chemical binding]; other site 101510021339 substrate binding site [chemical binding]; other site 101510021340 activation loop (A-loop); other site 101510021341 NHL repeat; Region: NHL; pfam01436 101510021342 Uncharacterized conserved protein [Function unknown]; Region: COG3391 101510021343 NHL repeat; Region: NHL; pfam01436 101510021344 NHL repeat; Region: NHL; pfam01436 101510021345 NHL repeat; Region: NHL; pfam01436 101510021346 putative transposase OrfB; Reviewed; Region: PHA02517 101510021347 HTH-like domain; Region: HTH_21; pfam13276 101510021348 Integrase core domain; Region: rve; pfam00665 101510021349 Integrase core domain; Region: rve_3; pfam13683 101510021350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 101510021351 Transposase; Region: HTH_Tnp_1; cl17663 101510021352 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 101510021353 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 101510021354 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 101510021355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510021356 ABC-ATPase subunit interface; other site 101510021357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510021358 dimer interface [polypeptide binding]; other site 101510021359 conserved gate region; other site 101510021360 putative PBP binding loops; other site 101510021361 ABC-ATPase subunit interface; other site 101510021362 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 101510021363 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 101510021364 Walker A/P-loop; other site 101510021365 ATP binding site [chemical binding]; other site 101510021366 Q-loop/lid; other site 101510021367 ABC transporter signature motif; other site 101510021368 Walker B; other site 101510021369 D-loop; other site 101510021370 H-loop/switch region; other site 101510021371 TOBE domain; Region: TOBE_2; pfam08402 101510021372 putative methyltransferase; Provisional; Region: PRK14967 101510021373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510021374 S-adenosylmethionine binding site [chemical binding]; other site 101510021375 Condensation domain; Region: Condensation; pfam00668 101510021376 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 101510021377 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 101510021378 acyl-activating enzyme (AAE) consensus motif; other site 101510021379 AMP binding site [chemical binding]; other site 101510021380 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510021381 Condensation domain; Region: Condensation; pfam00668 101510021382 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 101510021383 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 101510021384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510021385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510021386 active site 101510021387 phosphorylation site [posttranslational modification] 101510021388 intermolecular recognition site; other site 101510021389 dimerization interface [polypeptide binding]; other site 101510021390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510021391 DNA binding site [nucleotide binding] 101510021392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510021393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 101510021394 dimerization interface [polypeptide binding]; other site 101510021395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510021396 dimer interface [polypeptide binding]; other site 101510021397 phosphorylation site [posttranslational modification] 101510021398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510021399 ATP binding site [chemical binding]; other site 101510021400 Mg2+ binding site [ion binding]; other site 101510021401 G-X-G motif; other site 101510021402 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 101510021403 active site 101510021404 catalytic triad [active] 101510021405 oxyanion hole [active] 101510021406 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 101510021407 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 101510021408 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 101510021409 active site 101510021410 Interferon-induced transmembrane protein; Region: CD225; pfam04505 101510021411 hypothetical protein; Provisional; Region: PRK13685 101510021412 Aerotolerance regulator N-terminal; Region: BatA; cl06567 101510021413 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 101510021414 metal ion-dependent adhesion site (MIDAS); other site 101510021415 Putative esterase; Region: Esterase; pfam00756 101510021416 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 101510021417 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 101510021418 NodB motif; other site 101510021419 active site 101510021420 catalytic site [active] 101510021421 metal binding site [ion binding]; metal-binding site 101510021422 MspA; Region: MspA; pfam09203 101510021423 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510021424 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 101510021425 Walker A/P-loop; other site 101510021426 ATP binding site [chemical binding]; other site 101510021427 Q-loop/lid; other site 101510021428 ABC transporter signature motif; other site 101510021429 Walker B; other site 101510021430 D-loop; other site 101510021431 H-loop/switch region; other site 101510021432 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510021433 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 101510021434 Walker A/P-loop; other site 101510021435 ATP binding site [chemical binding]; other site 101510021436 Q-loop/lid; other site 101510021437 ABC transporter signature motif; other site 101510021438 Walker B; other site 101510021439 D-loop; other site 101510021440 H-loop/switch region; other site 101510021441 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 101510021442 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510021443 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510021444 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510021445 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 101510021446 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 101510021447 Domain of unknown function DUF20; Region: UPF0118; pfam01594 101510021448 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 101510021449 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 101510021450 active site 101510021451 catalytic site [active] 101510021452 Protein of unknown function (DUF664); Region: DUF664; pfam04978 101510021453 DinB superfamily; Region: DinB_2; pfam12867 101510021454 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510021455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510021456 DNA binding residues [nucleotide binding] 101510021457 dimerization interface [polypeptide binding]; other site 101510021458 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 101510021459 RNB domain; Region: RNB; pfam00773 101510021460 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 101510021461 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 101510021462 RNA-binding motif; other site 101510021463 DNA-binding site [nucleotide binding]; DNA binding site 101510021464 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 101510021465 Transposase domain (DUF772); Region: DUF772; pfam05598 101510021466 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 101510021467 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510021468 Homeodomain-like domain; Region: HTH_23; pfam13384 101510021469 Winged helix-turn helix; Region: HTH_29; pfam13551 101510021470 Homeodomain-like domain; Region: HTH_32; pfam13565 101510021471 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510021472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510021473 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510021474 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510021475 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 101510021476 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510021477 MULE transposase domain; Region: MULE; pfam10551 101510021478 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 101510021479 Helix-turn-helix domain; Region: HTH_38; pfam13936 101510021480 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510021481 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510021482 Homeodomain-like domain; Region: HTH_23; pfam13384 101510021483 Winged helix-turn helix; Region: HTH_29; pfam13551 101510021484 Homeodomain-like domain; Region: HTH_32; pfam13565 101510021485 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510021486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510021487 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510021488 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510021489 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510021490 Magnesium ion binding site [ion binding]; other site 101510021491 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510021492 active site 101510021493 Int/Topo IB signature motif; other site 101510021494 DNA binding site [nucleotide binding] 101510021495 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510021496 Helicase associated domain; Region: HA; pfam03457 101510021497 Helicase associated domain; Region: HA; pfam03457 101510021498 Lsr2; Region: Lsr2; pfam11774 101510021499 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510021500 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510021501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510021502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510021503 RNB domain; Region: RNB; pfam00773 101510021504 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054 101510021505 dsRNA binding site [nucleotide binding]; other site 101510021506 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 101510021507 dsRNA binding site [nucleotide binding]; other site 101510021508 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 101510021509 nudix motif; other site 101510021510 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 101510021511 adenylosuccinate synthase; Region: purA; TIGR00184 101510021512 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 101510021513 DNA-binding site [nucleotide binding]; DNA binding site 101510021514 RNA-binding motif; other site 101510021515 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 101510021516 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510021517 inhibitor-cofactor binding pocket; inhibition site 101510021518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510021519 catalytic residue [active] 101510021520 acetylornithine deacetylase; Validated; Region: PRK06915 101510021521 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 101510021522 metal binding site [ion binding]; metal-binding site 101510021523 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510021524 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510021525 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510021526 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 101510021527 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 101510021528 tetramer interface [polypeptide binding]; other site 101510021529 TPP-binding site [chemical binding]; other site 101510021530 heterodimer interface [polypeptide binding]; other site 101510021531 phosphorylation loop region [posttranslational modification] 101510021532 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 101510021533 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 101510021534 alpha subunit interface [polypeptide binding]; other site 101510021535 TPP binding site [chemical binding]; other site 101510021536 heterodimer interface [polypeptide binding]; other site 101510021537 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510021538 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 101510021539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021540 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510021541 putative substrate translocation pore; other site 101510021542 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510021543 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510021544 NAD(P) binding site [chemical binding]; other site 101510021545 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 101510021546 homotrimer interaction site [polypeptide binding]; other site 101510021547 putative active site [active] 101510021548 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 101510021549 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 101510021550 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510021551 catalytic residue [active] 101510021552 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510021553 classical (c) SDRs; Region: SDR_c; cd05233 101510021554 NAD(P) binding site [chemical binding]; other site 101510021555 active site 101510021556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510021557 classical (c) SDRs; Region: SDR_c; cd05233 101510021558 NAD(P) binding site [chemical binding]; other site 101510021559 active site 101510021560 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510021561 classical (c) SDRs; Region: SDR_c; cd05233 101510021562 NAD(P) binding site [chemical binding]; other site 101510021563 active site 101510021564 Uncharacterized conserved protein [Function unknown]; Region: COG1359 101510021565 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510021566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510021567 putative DNA binding site [nucleotide binding]; other site 101510021568 putative Zn2+ binding site [ion binding]; other site 101510021569 AsnC family; Region: AsnC_trans_reg; pfam01037 101510021570 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510021571 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 101510021572 NAD binding site [chemical binding]; other site 101510021573 substrate binding site [chemical binding]; other site 101510021574 catalytic Zn binding site [ion binding]; other site 101510021575 structural Zn binding site [ion binding]; other site 101510021576 Amino acid permease; Region: AA_permease_2; pfam13520 101510021577 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510021578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510021579 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 101510021580 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 101510021581 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510021582 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 101510021583 [2Fe-2S] cluster binding site [ion binding]; other site 101510021584 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 101510021585 alpha subunit interface [polypeptide binding]; other site 101510021586 active site 101510021587 substrate binding site [chemical binding]; other site 101510021588 Fe binding site [ion binding]; other site 101510021589 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510021590 Lsr2; Region: Lsr2; pfam11774 101510021591 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510021592 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510021593 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510021594 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 101510021595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510021596 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 101510021597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510021598 acyl-activating enzyme (AAE) consensus motif; other site 101510021599 AMP binding site [chemical binding]; other site 101510021600 active site 101510021601 CoA binding site [chemical binding]; other site 101510021602 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 101510021603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 101510021604 Cupin domain; Region: Cupin_2; pfam07883 101510021605 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 101510021606 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510021607 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 101510021608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510021609 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 101510021610 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 101510021611 active site 101510021612 nucleotide binding site [chemical binding]; other site 101510021613 HIGH motif; other site 101510021614 KMSKS motif; other site 101510021615 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 101510021616 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 101510021617 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 101510021618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 101510021619 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 101510021620 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 101510021621 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510021622 hydrophobic ligand binding site; other site 101510021623 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 101510021624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510021625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021626 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 101510021627 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 101510021628 hypothetical protein; Provisional; Region: PRK12438 101510021629 hypothetical protein; Validated; Region: PRK00068 101510021630 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510021631 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 101510021632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510021633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510021634 active site 101510021635 type III secretion system ATPase; Validated; Region: PRK05922 101510021636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510021637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510021638 salt bridge; other site 101510021639 non-specific DNA binding site [nucleotide binding]; other site 101510021640 sequence-specific DNA binding site [nucleotide binding]; other site 101510021641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510021642 salt bridge; other site 101510021643 non-specific DNA binding site [nucleotide binding]; other site 101510021644 sequence-specific DNA binding site [nucleotide binding]; other site 101510021645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510021646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510021647 non-specific DNA binding site [nucleotide binding]; other site 101510021648 salt bridge; other site 101510021649 sequence-specific DNA binding site [nucleotide binding]; other site 101510021650 Domain of unknown function (DUF955); Region: DUF955; cl01076 101510021651 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510021652 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510021653 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 101510021654 N-acetyl-D-glucosamine binding site [chemical binding]; other site 101510021655 catalytic residue [active] 101510021656 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510021657 NlpC/P60 family; Region: NLPC_P60; cl17555 101510021658 AAA-like domain; Region: AAA_10; pfam12846 101510021659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510021660 Walker A motif; other site 101510021661 ATP binding site [chemical binding]; other site 101510021662 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510021663 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 101510021664 P-loop; other site 101510021665 Magnesium ion binding site [ion binding]; other site 101510021666 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 101510021667 Cutinase; Region: Cutinase; pfam01083 101510021668 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 101510021669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510021670 dimerization interface [polypeptide binding]; other site 101510021671 putative DNA binding site [nucleotide binding]; other site 101510021672 putative Zn2+ binding site [ion binding]; other site 101510021673 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 101510021674 putative hydrophobic ligand binding site [chemical binding]; other site 101510021675 RibD C-terminal domain; Region: RibD_C; cl17279 101510021676 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 101510021677 homodimer interface [polypeptide binding]; other site 101510021678 putative active site [active] 101510021679 catalytic site [active] 101510021680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510021681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510021682 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 101510021683 Ligand Binding Site [chemical binding]; other site 101510021684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510021685 ATP binding site [chemical binding]; other site 101510021686 Mg2+ binding site [ion binding]; other site 101510021687 G-X-G motif; other site 101510021688 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 101510021689 K+ potassium transporter; Region: K_trans; cl15781 101510021690 Predicted membrane protein [Function unknown]; Region: COG2261 101510021691 PQQ-like domain; Region: PQQ_2; pfam13360 101510021692 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 101510021693 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 101510021694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 101510021695 AAA domain; Region: AAA_33; pfam13671 101510021696 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 101510021697 PAS domain; Region: PAS_9; pfam13426 101510021698 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 101510021699 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 101510021700 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 101510021701 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 101510021702 metal binding site [ion binding]; metal-binding site 101510021703 active site 101510021704 I-site; other site 101510021705 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 101510021706 PLD-like domain; Region: PLDc_2; pfam13091 101510021707 homodimer interface [polypeptide binding]; other site 101510021708 putative active site [active] 101510021709 catalytic site [active] 101510021710 Cutinase; Region: Cutinase; pfam01083 101510021711 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 101510021712 Helix-turn-helix domain; Region: HTH_28; pfam13518 101510021713 Integrase core domain; Region: rve; pfam00665 101510021714 Integrase core domain; Region: rve_3; cl15866 101510021715 AAA domain; Region: AAA_22; pfam13401 101510021716 Bacterial TniB protein; Region: TniB; pfam05621 101510021717 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 101510021718 active site 101510021719 conformational flexibility of ligand binding pocket; other site 101510021720 ADP-ribosylating toxin turn-turn motif; other site 101510021721 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 101510021722 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 101510021723 Uncharacterized conserved protein [Function unknown]; Region: COG3422 101510021724 Lsr2; Region: Lsr2; pfam11774 101510021725 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 101510021726 active site 101510021727 Uncharacterized conserved protein [Function unknown]; Region: COG3268 101510021728 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 101510021729 Helix-turn-helix domain; Region: HTH_17; cl17695 101510021730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510021731 S-adenosylmethionine binding site [chemical binding]; other site 101510021732 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 101510021733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 101510021734 PAS fold; Region: PAS_3; pfam08447 101510021735 putative active site [active] 101510021736 heme pocket [chemical binding]; other site 101510021737 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 101510021738 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510021739 active site 101510021740 RES domain; Region: RES; pfam08808 101510021741 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 101510021742 RNB domain; Region: RNB; pfam00773 101510021743 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 101510021744 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 101510021745 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 101510021746 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510021747 active site 101510021748 DNA binding site [nucleotide binding] 101510021749 Int/Topo IB signature motif; other site 101510021750 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 101510021751 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 101510021752 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 101510021753 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 101510021754 NAD(P) binding site [chemical binding]; other site 101510021755 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 101510021756 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510021757 inhibitor-cofactor binding pocket; inhibition site 101510021758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510021759 catalytic residue [active] 101510021760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510021761 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510021762 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 101510021763 putative dimerization interface [polypeptide binding]; other site 101510021764 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510021765 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510021766 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510021767 DNA-binding site [nucleotide binding]; DNA binding site 101510021768 FCD domain; Region: FCD; pfam07729 101510021769 succinic semialdehyde dehydrogenase; Region: PLN02278 101510021770 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 101510021771 tetramerization interface [polypeptide binding]; other site 101510021772 NAD(P) binding site [chemical binding]; other site 101510021773 catalytic residues [active] 101510021774 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 101510021775 FAD binding domain; Region: FAD_binding_4; pfam01565 101510021776 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 101510021777 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510021778 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510021779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510021780 DNA-binding site [nucleotide binding]; DNA binding site 101510021781 FCD domain; Region: FCD; pfam07729 101510021782 amino acid transporter; Region: 2A0306; TIGR00909 101510021783 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 101510021784 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510021785 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 101510021786 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 101510021787 active site 101510021788 benzoate transport; Region: 2A0115; TIGR00895 101510021789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021790 putative substrate translocation pore; other site 101510021791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021792 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 101510021793 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 101510021794 putative active site [active] 101510021795 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 101510021796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 101510021797 motif II; other site 101510021798 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 101510021799 tartrate dehydrogenase; Provisional; Region: PRK08194 101510021800 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 101510021801 Nitronate monooxygenase; Region: NMO; pfam03060 101510021802 FMN binding site [chemical binding]; other site 101510021803 substrate binding site [chemical binding]; other site 101510021804 putative catalytic residue [active] 101510021805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510021806 dimerization interface [polypeptide binding]; other site 101510021807 putative DNA binding site [nucleotide binding]; other site 101510021808 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510021809 putative Zn2+ binding site [ion binding]; other site 101510021810 AsnC family; Region: AsnC_trans_reg; pfam01037 101510021811 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 101510021812 citrate synthase 2; Provisional; Region: PRK12350 101510021813 Citrate synthase; Region: Citrate_synt; pfam00285 101510021814 oxalacetate binding site [chemical binding]; other site 101510021815 citrylCoA binding site [chemical binding]; other site 101510021816 coenzyme A binding site [chemical binding]; other site 101510021817 catalytic triad [active] 101510021818 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 101510021819 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510021820 iron-sulfur cluster [ion binding]; other site 101510021821 [2Fe-2S] cluster binding site [ion binding]; other site 101510021822 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 101510021823 Ligand binding site [chemical binding]; other site 101510021824 Electron transfer flavoprotein domain; Region: ETF; pfam01012 101510021825 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 101510021826 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 101510021827 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 101510021828 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 101510021829 fumarate hydratase; Provisional; Region: PRK06246 101510021830 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 101510021831 Iron-sulfur protein interface; other site 101510021832 proximal heme binding site [chemical binding]; other site 101510021833 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 101510021834 Iron-sulfur protein interface; other site 101510021835 proximal heme binding site [chemical binding]; other site 101510021836 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 101510021837 L-aspartate oxidase; Provisional; Region: PRK06175 101510021838 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 101510021839 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 101510021840 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510021841 catalytic loop [active] 101510021842 iron binding site [ion binding]; other site 101510021843 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 101510021844 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510021845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021846 putative substrate translocation pore; other site 101510021847 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510021848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510021849 putative DNA binding site [nucleotide binding]; other site 101510021850 putative Zn2+ binding site [ion binding]; other site 101510021851 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510021852 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510021853 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 101510021854 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510021855 putative transposase OrfB; Reviewed; Region: PHA02517 101510021856 HTH-like domain; Region: HTH_21; pfam13276 101510021857 Integrase core domain; Region: rve; pfam00665 101510021858 Integrase core domain; Region: rve_3; pfam13683 101510021859 Transposase; Region: HTH_Tnp_1; cl17663 101510021860 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510021861 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510021862 NAD(P) binding site [chemical binding]; other site 101510021863 catalytic residues [active] 101510021864 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510021865 Transcription factor WhiB; Region: Whib; pfam02467 101510021866 NADH dehydrogenase-like protein; Provisional; Region: PTZ00318 101510021867 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 101510021868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510021869 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 101510021870 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 101510021871 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 101510021872 ligand binding site [chemical binding]; other site 101510021873 NAD binding site [chemical binding]; other site 101510021874 dimerization interface [polypeptide binding]; other site 101510021875 catalytic site [active] 101510021876 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 101510021877 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 101510021878 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 101510021879 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510021880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510021881 DNA-binding site [nucleotide binding]; DNA binding site 101510021882 FCD domain; Region: FCD; pfam07729 101510021883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510021884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510021885 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 101510021886 putative dimerization interface [polypeptide binding]; other site 101510021887 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 101510021888 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510021889 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510021890 active site 101510021891 ATP binding site [chemical binding]; other site 101510021892 substrate binding site [chemical binding]; other site 101510021893 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510021894 substrate binding site [chemical binding]; other site 101510021895 activation loop (A-loop); other site 101510021896 activation loop (A-loop); other site 101510021897 Predicted ATPase [General function prediction only]; Region: COG3903 101510021898 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510021899 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510021900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510021901 DNA binding residues [nucleotide binding] 101510021902 dimerization interface [polypeptide binding]; other site 101510021903 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510021904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510021905 DNA-binding site [nucleotide binding]; DNA binding site 101510021906 FCD domain; Region: FCD; pfam07729 101510021907 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 101510021908 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 101510021909 active site pocket [active] 101510021910 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 101510021911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021912 putative substrate translocation pore; other site 101510021913 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 101510021914 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 101510021915 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 101510021916 Transposase; Region: HTH_Tnp_1; cl17663 101510021917 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 101510021918 putative metal binding site [ion binding]; other site 101510021919 enoyl-CoA hydratase; Validated; Region: PRK08139 101510021920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510021921 substrate binding site [chemical binding]; other site 101510021922 oxyanion hole (OAH) forming residues; other site 101510021923 trimer interface [polypeptide binding]; other site 101510021924 putative acyltransferase; Provisional; Region: PRK05790 101510021925 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510021926 dimer interface [polypeptide binding]; other site 101510021927 active site 101510021928 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 101510021929 dimer interaction site [polypeptide binding]; other site 101510021930 substrate-binding tunnel; other site 101510021931 active site 101510021932 catalytic site [active] 101510021933 substrate binding site [chemical binding]; other site 101510021934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021935 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510021936 putative substrate translocation pore; other site 101510021937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510021938 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510021939 putative substrate translocation pore; other site 101510021940 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 101510021941 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510021942 thiolase; Provisional; Region: PRK06158 101510021943 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510021944 active site 101510021945 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 101510021946 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 101510021947 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 101510021948 acyl-activating enzyme (AAE) consensus motif; other site 101510021949 putative AMP binding site [chemical binding]; other site 101510021950 putative active site [active] 101510021951 putative CoA binding site [chemical binding]; other site 101510021952 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 101510021953 catalytic residues [active] 101510021954 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 101510021955 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510021956 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510021957 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510021958 OsmC-like protein; Region: OsmC; pfam02566 101510021959 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 101510021960 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510021961 Transcription factor WhiB; Region: Whib; pfam02467 101510021962 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 101510021963 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 101510021964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510021965 homodimer interface [polypeptide binding]; other site 101510021966 catalytic residue [active] 101510021967 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510021968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510021969 putative DNA binding site [nucleotide binding]; other site 101510021970 putative Zn2+ binding site [ion binding]; other site 101510021971 AsnC family; Region: AsnC_trans_reg; pfam01037 101510021972 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 101510021973 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 101510021974 homotrimer interaction site [polypeptide binding]; other site 101510021975 putative active site [active] 101510021976 YheO-like PAS domain; Region: PAS_6; pfam08348 101510021977 HTH domain; Region: HTH_22; pfam13309 101510021978 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 101510021979 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 101510021980 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 101510021981 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510021982 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510021983 active site 101510021984 ATP binding site [chemical binding]; other site 101510021985 substrate binding site [chemical binding]; other site 101510021986 activation loop (A-loop); other site 101510021987 AAA ATPase domain; Region: AAA_16; pfam13191 101510021988 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510021989 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 101510021990 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510021991 active site residue [active] 101510021992 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510021993 active site residue [active] 101510021994 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510021995 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 101510021996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510021997 DNA-binding site [nucleotide binding]; DNA binding site 101510021998 UTRA domain; Region: UTRA; pfam07702 101510021999 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510022000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510022001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510022002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510022003 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510022004 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510022005 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510022006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510022007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510022008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 101510022009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510022010 OsmC-like protein; Region: OsmC; pfam02566 101510022011 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 101510022012 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510022013 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 101510022014 active site 101510022015 FMN binding site [chemical binding]; other site 101510022016 substrate binding site [chemical binding]; other site 101510022017 putative catalytic residue [active] 101510022018 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 101510022019 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510022020 NAD(P) binding site [chemical binding]; other site 101510022021 catalytic residues [active] 101510022022 Protein of unknown function (DUF779); Region: DUF779; pfam05610 101510022023 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 101510022024 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 101510022025 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 101510022026 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 101510022027 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510022028 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 101510022029 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 101510022030 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510022031 carboxyltransferase (CT) interaction site; other site 101510022032 biotinylation site [posttranslational modification]; other site 101510022033 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 101510022034 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 101510022035 acyl-activating enzyme (AAE) consensus motif; other site 101510022036 putative AMP binding site [chemical binding]; other site 101510022037 putative active site [active] 101510022038 putative CoA binding site [chemical binding]; other site 101510022039 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 101510022040 hexamer interface [polypeptide binding]; other site 101510022041 active site 2 [active] 101510022042 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510022043 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 101510022044 Malic enzyme, N-terminal domain; Region: malic; pfam00390 101510022045 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 101510022046 putative NAD(P) binding site [chemical binding]; other site 101510022047 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 101510022048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 101510022049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510022050 OsmC-like protein; Region: OsmC; pfam02566 101510022051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510022052 putative substrate translocation pore; other site 101510022053 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510022054 enoyl-CoA hydratase; Validated; Region: PRK08139 101510022055 substrate binding site [chemical binding]; other site 101510022056 oxyanion hole (OAH) forming residues; other site 101510022057 trimer interface [polypeptide binding]; other site 101510022058 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 101510022059 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 101510022060 acyl-activating enzyme (AAE) consensus motif; other site 101510022061 putative AMP binding site [chemical binding]; other site 101510022062 putative active site [active] 101510022063 putative CoA binding site [chemical binding]; other site 101510022064 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 101510022065 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 101510022066 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 101510022067 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510022068 Integrase core domain; Region: rve; pfam00665 101510022069 Integrase core domain; Region: rve_3; cl15866 101510022070 Cupin domain; Region: Cupin_2; pfam07883 101510022071 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510022072 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 101510022073 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510022074 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510022075 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510022076 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 101510022077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022078 NAD(P) binding site [chemical binding]; other site 101510022079 active site 101510022080 hypothetical protein; Provisional; Region: PRK06208 101510022081 intersubunit interface [polypeptide binding]; other site 101510022082 active site 101510022083 Zn2+ binding site [ion binding]; other site 101510022084 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510022085 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510022086 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 101510022087 Domain of unknown function (DUF336); Region: DUF336; pfam03928 101510022088 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 101510022089 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 101510022090 NAD binding site [chemical binding]; other site 101510022091 substrate binding site [chemical binding]; other site 101510022092 catalytic Zn binding site [ion binding]; other site 101510022093 structural Zn binding site [ion binding]; other site 101510022094 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 101510022095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510022096 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 101510022097 dimerization interface [polypeptide binding]; other site 101510022098 substrate binding pocket [chemical binding]; other site 101510022099 choline dehydrogenase; Validated; Region: PRK02106 101510022100 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 101510022101 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 101510022102 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 101510022103 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 101510022104 inhibitor site; inhibition site 101510022105 active site 101510022106 dimer interface [polypeptide binding]; other site 101510022107 catalytic residue [active] 101510022108 4-coumarate--CoA ligase; Region: PLN02246 101510022109 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 101510022110 acyl-activating enzyme (AAE) consensus motif; other site 101510022111 active site 101510022112 putative CoA binding site [chemical binding]; other site 101510022113 AMP binding site [chemical binding]; other site 101510022114 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510022115 phosphate binding site [ion binding]; other site 101510022116 Transposase [DNA replication, recombination, and repair]; Region: COG5421 101510022117 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510022118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510022119 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510022120 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 101510022121 active site 101510022122 Zn2+ binding site [ion binding]; other site 101510022123 intersubunit interface [polypeptide binding]; other site 101510022124 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 101510022125 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 101510022126 ATP binding site [chemical binding]; other site 101510022127 substrate binding site [chemical binding]; other site 101510022128 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510022129 classical (c) SDRs; Region: SDR_c; cd05233 101510022130 NAD(P) binding site [chemical binding]; other site 101510022131 active site 101510022132 SnoaL-like domain; Region: SnoaL_4; pfam13577 101510022133 hypothetical protein; Provisional; Region: PRK06194 101510022134 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 101510022135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022136 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510022137 NAD(P) binding site [chemical binding]; other site 101510022138 active site 101510022139 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510022140 Cytochrome P450; Region: p450; cl12078 101510022141 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 101510022142 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510022143 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510022144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510022145 MarR family; Region: MarR_2; pfam12802 101510022146 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510022147 MarR family; Region: MarR; pfam01047 101510022148 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 101510022149 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 101510022150 putative ligand binding site [chemical binding]; other site 101510022151 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 101510022152 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 101510022153 Walker A/P-loop; other site 101510022154 ATP binding site [chemical binding]; other site 101510022155 Q-loop/lid; other site 101510022156 ABC transporter signature motif; other site 101510022157 Walker B; other site 101510022158 D-loop; other site 101510022159 H-loop/switch region; other site 101510022160 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 101510022161 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 101510022162 Walker A/P-loop; other site 101510022163 ATP binding site [chemical binding]; other site 101510022164 Q-loop/lid; other site 101510022165 ABC transporter signature motif; other site 101510022166 Walker B; other site 101510022167 D-loop; other site 101510022168 H-loop/switch region; other site 101510022169 hypothetical protein; Validated; Region: PRK07121 101510022170 hypothetical protein; Validated; Region: PRK07121 101510022171 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510022172 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 101510022173 active site 101510022174 FMN binding site [chemical binding]; other site 101510022175 substrate binding site [chemical binding]; other site 101510022176 putative catalytic residue [active] 101510022177 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 101510022178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510022179 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510022180 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510022181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510022182 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510022183 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510022184 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 101510022185 FAD binding pocket [chemical binding]; other site 101510022186 FAD binding motif [chemical binding]; other site 101510022187 phosphate binding motif [ion binding]; other site 101510022188 beta-alpha-beta structure motif; other site 101510022189 NAD(p) ribose binding residues [chemical binding]; other site 101510022190 NAD binding pocket [chemical binding]; other site 101510022191 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 101510022192 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510022193 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510022194 catalytic loop [active] 101510022195 iron binding site [ion binding]; other site 101510022196 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510022197 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 101510022198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510022199 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510022200 active site 101510022201 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 101510022202 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 101510022203 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 101510022204 active site 101510022205 Fe binding site [ion binding]; other site 101510022206 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510022207 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 101510022208 active site 101510022209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022210 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 101510022211 NAD(P) binding site [chemical binding]; other site 101510022212 active site 101510022213 Homeodomain-like domain; Region: HTH_23; pfam13384 101510022214 Winged helix-turn helix; Region: HTH_29; pfam13551 101510022215 Homeodomain-like domain; Region: HTH_32; pfam13565 101510022216 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510022217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510022218 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510022219 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510022220 substrate binding pocket [chemical binding]; other site 101510022221 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510022222 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 101510022223 PGAP1-like protein; Region: PGAP1; pfam07819 101510022224 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 101510022225 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510022226 Transcriptional regulator PadR-like family; Region: PadR; cl17335 101510022227 acetaldehyde dehydrogenase; Validated; Region: PRK08300 101510022228 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510022229 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 101510022230 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 101510022231 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 101510022232 active site 101510022233 catalytic residues [active] 101510022234 metal binding site [ion binding]; metal-binding site 101510022235 DmpG-like communication domain; Region: DmpG_comm; pfam07836 101510022236 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 101510022237 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510022238 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510022239 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510022240 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 101510022241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510022242 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 101510022243 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510022244 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510022245 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510022246 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510022247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510022248 DNA-binding site [nucleotide binding]; DNA binding site 101510022249 FCD domain; Region: FCD; pfam07729 101510022250 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510022251 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510022252 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510022253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510022254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510022255 active site 101510022256 enoyl-CoA hydratase; Provisional; Region: PRK05870 101510022257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510022258 substrate binding site [chemical binding]; other site 101510022259 oxyanion hole (OAH) forming residues; other site 101510022260 trimer interface [polypeptide binding]; other site 101510022261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510022262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022263 NAD(P) binding site [chemical binding]; other site 101510022264 active site 101510022265 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510022266 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510022267 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510022268 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510022269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510022270 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510022271 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510022272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022274 classical (c) SDRs; Region: SDR_c; cd05233 101510022275 hypothetical protein; Provisional; Region: PRK06194 101510022276 NAD(P) binding site [chemical binding]; other site 101510022277 active site 101510022278 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510022279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510022280 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 101510022281 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510022282 enoyl-CoA hydratase; Region: PLN02864 101510022283 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 101510022284 active site 2 [active] 101510022285 active site 1 [active] 101510022286 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 101510022287 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510022288 Walker A/P-loop; other site 101510022289 ATP binding site [chemical binding]; other site 101510022290 Q-loop/lid; other site 101510022291 ABC transporter signature motif; other site 101510022292 Walker B; other site 101510022293 D-loop; other site 101510022294 H-loop/switch region; other site 101510022295 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 101510022296 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 101510022297 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 101510022298 Walker A/P-loop; other site 101510022299 ATP binding site [chemical binding]; other site 101510022300 Q-loop/lid; other site 101510022301 ABC transporter signature motif; other site 101510022302 Walker B; other site 101510022303 D-loop; other site 101510022304 H-loop/switch region; other site 101510022305 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 101510022306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 101510022307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510022308 putative PBP binding loops; other site 101510022309 dimer interface [polypeptide binding]; other site 101510022310 ABC-ATPase subunit interface; other site 101510022311 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 101510022312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510022313 dimer interface [polypeptide binding]; other site 101510022314 conserved gate region; other site 101510022315 putative PBP binding loops; other site 101510022316 ABC-ATPase subunit interface; other site 101510022317 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 101510022318 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 101510022319 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510022320 EthD domain; Region: EthD; cl17553 101510022321 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 101510022322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510022323 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510022324 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510022325 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 101510022326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510022327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510022328 OsmC-like protein; Region: OsmC; pfam02566 101510022329 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 101510022330 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 101510022331 FMN binding site [chemical binding]; other site 101510022332 active site 101510022333 substrate binding site [chemical binding]; other site 101510022334 catalytic residue [active] 101510022335 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 101510022336 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 101510022337 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 101510022338 catalytic residues [active] 101510022339 classical (c) SDRs; Region: SDR_c; cd05233 101510022340 NAD(P) binding site [chemical binding]; other site 101510022341 active site 101510022342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510022343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510022344 Integrase core domain; Region: rve; pfam00665 101510022345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 101510022346 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 101510022347 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 101510022348 catalytic residues [active] 101510022349 catalytic nucleophile [active] 101510022350 Homeodomain-like domain; Region: HTH_23; cl17451 101510022351 Winged helix-turn helix; Region: HTH_29; pfam13551 101510022352 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 101510022353 classical (c) SDRs; Region: SDR_c; cd05233 101510022354 NAD(P) binding site [chemical binding]; other site 101510022355 active site 101510022356 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510022357 classical (c) SDRs; Region: SDR_c; cd05233 101510022358 NAD(P) binding site [chemical binding]; other site 101510022359 active site 101510022360 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510022361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510022362 TM-ABC transporter signature motif; other site 101510022363 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510022364 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 101510022365 Walker A/P-loop; other site 101510022366 ATP binding site [chemical binding]; other site 101510022367 Q-loop/lid; other site 101510022368 ABC transporter signature motif; other site 101510022369 Walker B; other site 101510022370 D-loop; other site 101510022371 H-loop/switch region; other site 101510022372 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510022373 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 101510022374 ligand binding site [chemical binding]; other site 101510022375 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510022376 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 101510022377 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 101510022378 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 101510022379 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510022380 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 101510022381 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510022382 Transmembrane secretion effector; Region: MFS_3; pfam05977 101510022383 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 101510022384 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 101510022385 Lipase (class 2); Region: Lipase_2; pfam01674 101510022386 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 101510022387 Secretory lipase; Region: LIP; pfam03583 101510022388 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 101510022389 Transcription factor WhiB; Region: Whib; pfam02467 101510022390 Lsr2; Region: Lsr2; pfam11774 101510022391 Lsr2; Region: Lsr2; pfam11774 101510022392 Lsr2; Region: Lsr2; pfam11774 101510022393 Lsr2; Region: Lsr2; pfam11774 101510022394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 101510022395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 101510022396 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 101510022397 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 101510022398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 101510022399 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 101510022400 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 101510022401 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 101510022402 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 101510022403 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 101510022404 TIR domain; Region: TIR_2; pfam13676 101510022405 TIR domain; Region: TIR_2; pfam13676 101510022406 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 101510022407 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 101510022408 putative metal binding site [ion binding]; other site 101510022409 TIR domain; Region: TIR_2; pfam13676 101510022410 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 101510022411 active site 101510022412 catalytic triad [active] 101510022413 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510022414 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510022415 putative transposase OrfB; Reviewed; Region: PHA02517 101510022416 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 101510022417 aromatic arch; other site 101510022418 DCoH dimer interaction site [polypeptide binding]; other site 101510022419 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 101510022420 DCoH tetramer interaction site [polypeptide binding]; other site 101510022421 substrate binding site [chemical binding]; other site 101510022422 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510022423 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510022424 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510022425 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 101510022426 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 101510022427 active site 101510022428 Integrase core domain; Region: rve_3; pfam13683 101510022429 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 101510022430 catalytic residue [active] 101510022431 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 101510022432 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 101510022433 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 101510022434 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 101510022435 active site 101510022436 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 101510022437 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 101510022438 PA14 domain; Region: PA14; cl08459 101510022439 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 101510022440 Family description; Region: VCBS; pfam13517 101510022441 Family description; Region: VCBS; pfam13517 101510022442 Family description; Region: VCBS; pfam13517 101510022443 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 101510022444 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 101510022445 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 101510022446 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 101510022447 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 101510022448 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 101510022449 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 101510022450 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 101510022451 active site 101510022452 metal binding site [ion binding]; metal-binding site 101510022453 interdomain interaction site; other site 101510022454 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510022455 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510022456 Magnesium ion binding site [ion binding]; other site 101510022457 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 101510022458 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 101510022459 Cutinase; Region: Cutinase; pfam01083 101510022460 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 101510022461 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 101510022462 AAA-like domain; Region: AAA_10; pfam12846 101510022463 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510022464 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510022465 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 101510022466 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 101510022467 N-acetyl-D-glucosamine binding site [chemical binding]; other site 101510022468 catalytic residue [active] 101510022469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510022470 Walker A motif; other site 101510022471 ATP binding site [chemical binding]; other site 101510022472 Walker B motif; other site 101510022473 arginine finger; other site 101510022474 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510022475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510022476 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510022477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510022478 non-specific DNA binding site [nucleotide binding]; other site 101510022479 salt bridge; other site 101510022480 sequence-specific DNA binding site [nucleotide binding]; other site 101510022481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510022482 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510022483 non-specific DNA binding site [nucleotide binding]; other site 101510022484 salt bridge; other site 101510022485 sequence-specific DNA binding site [nucleotide binding]; other site 101510022486 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510022487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510022488 sequence-specific DNA binding site [nucleotide binding]; other site 101510022489 salt bridge; other site 101510022490 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 101510022491 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 101510022492 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 101510022493 ATP binding site [chemical binding]; other site 101510022494 Walker B motif; other site 101510022495 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 101510022496 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 101510022497 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510022498 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510022499 NlpC/P60 family; Region: NLPC_P60; pfam00877 101510022500 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 101510022501 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 101510022502 active site 101510022503 catalytic site [active] 101510022504 substrate binding site [chemical binding]; other site 101510022505 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 101510022506 Active Sites [active] 101510022507 CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865 101510022508 Transcription factor WhiB; Region: Whib; pfam02467 101510022509 Homeodomain-like domain; Region: HTH_23; pfam13384 101510022510 Winged helix-turn helix; Region: HTH_29; pfam13551 101510022511 Homeodomain-like domain; Region: HTH_32; pfam13565 101510022512 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510022513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510022514 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510022515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510022516 non-specific DNA binding site [nucleotide binding]; other site 101510022517 salt bridge; other site 101510022518 sequence-specific DNA binding site [nucleotide binding]; other site 101510022519 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 101510022520 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 101510022521 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 101510022522 metal ion-dependent adhesion site (MIDAS); other site 101510022523 AAA domain; Region: AAA_12; pfam13087 101510022524 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510022525 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510022526 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510022527 Helicase associated domain; Region: HA; pfam03457 101510022528 Helicase associated domain; Region: HA; pfam03457 101510022529 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 101510022530 putative active site [active] 101510022531 catalytic site [active] 101510022532 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510022533 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 101510022534 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510022535 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510022536 DNA binding site [nucleotide binding] 101510022537 active site 101510022538 Int/Topo IB signature motif; other site 101510022539 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 101510022540 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 101510022541 active site 101510022542 catalytic residues [active] 101510022543 metal binding site [ion binding]; metal-binding site 101510022544 DmpG-like communication domain; Region: DmpG_comm; pfam07836 101510022545 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 101510022546 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510022547 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510022548 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510022549 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 101510022550 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 101510022551 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 101510022552 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 101510022553 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510022554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510022555 substrate binding site [chemical binding]; other site 101510022556 oxyanion hole (OAH) forming residues; other site 101510022557 trimer interface [polypeptide binding]; other site 101510022558 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510022559 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510022560 acyl-activating enzyme (AAE) consensus motif; other site 101510022561 AMP binding site [chemical binding]; other site 101510022562 active site 101510022563 CoA binding site [chemical binding]; other site 101510022564 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510022565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510022566 active site 101510022567 phosphorylation site [posttranslational modification] 101510022568 intermolecular recognition site; other site 101510022569 dimerization interface [polypeptide binding]; other site 101510022570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510022571 DNA binding residues [nucleotide binding] 101510022572 dimerization interface [polypeptide binding]; other site 101510022573 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 101510022574 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510022575 active site 101510022576 ATP binding site [chemical binding]; other site 101510022577 substrate binding site [chemical binding]; other site 101510022578 activation loop (A-loop); other site 101510022579 Predicted ATPase [General function prediction only]; Region: COG3899 101510022580 AAA ATPase domain; Region: AAA_16; pfam13191 101510022581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510022582 Histidine kinase; Region: HisKA_3; pfam07730 101510022583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510022584 ATP binding site [chemical binding]; other site 101510022585 Mg2+ binding site [ion binding]; other site 101510022586 G-X-G motif; other site 101510022587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 101510022588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510022589 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 101510022590 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 101510022591 NAD binding site [chemical binding]; other site 101510022592 active site 101510022593 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 101510022594 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 101510022595 NAD(P) binding site [chemical binding]; other site 101510022596 catalytic residues [active] 101510022597 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510022598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510022599 active site 101510022600 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510022601 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510022602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022603 active site 101510022604 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 101510022605 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510022606 iron-sulfur cluster [ion binding]; other site 101510022607 [2Fe-2S] cluster binding site [ion binding]; other site 101510022608 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 101510022609 beta subunit interface [polypeptide binding]; other site 101510022610 alpha subunit interface [polypeptide binding]; other site 101510022611 active site 101510022612 substrate binding site [chemical binding]; other site 101510022613 Fe binding site [ion binding]; other site 101510022614 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 101510022615 inter-subunit interface; other site 101510022616 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 101510022617 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 101510022618 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 101510022619 active site 101510022620 Fe binding site [ion binding]; other site 101510022621 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 101510022622 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510022623 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 101510022624 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510022625 SnoaL-like domain; Region: SnoaL_2; pfam12680 101510022626 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510022627 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510022628 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 101510022629 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510022630 iron-sulfur cluster [ion binding]; other site 101510022631 [2Fe-2S] cluster binding site [ion binding]; other site 101510022632 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 101510022633 beta subunit interface [polypeptide binding]; other site 101510022634 alpha subunit interface [polypeptide binding]; other site 101510022635 active site 101510022636 substrate binding site [chemical binding]; other site 101510022637 Fe binding site [ion binding]; other site 101510022638 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 101510022639 inter-subunit interface; other site 101510022640 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 101510022641 [2Fe-2S] cluster binding site [ion binding]; other site 101510022642 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 101510022643 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510022644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510022645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510022646 putative substrate translocation pore; other site 101510022647 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510022648 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 101510022649 active site 101510022650 ATP binding site [chemical binding]; other site 101510022651 substrate binding site [chemical binding]; other site 101510022652 activation loop (A-loop); other site 101510022653 Predicted ATPase [General function prediction only]; Region: COG3899 101510022654 AAA ATPase domain; Region: AAA_16; pfam13191 101510022655 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510022656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 101510022657 Histidine kinase; Region: HisKA_3; pfam07730 101510022658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510022659 ATP binding site [chemical binding]; other site 101510022660 Mg2+ binding site [ion binding]; other site 101510022661 G-X-G motif; other site 101510022662 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510022663 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510022664 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510022665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510022666 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510022667 SCP-2 sterol transfer family; Region: SCP2; pfam02036 101510022668 Coenzyme A transferase; Region: CoA_trans; cl17247 101510022669 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 101510022670 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 101510022671 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 101510022672 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 101510022673 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 101510022674 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 101510022675 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 101510022676 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 101510022677 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510022678 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 101510022679 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510022680 MarR family; Region: MarR_2; pfam12802 101510022681 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 101510022682 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 101510022683 putative ligand binding site [chemical binding]; other site 101510022684 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 101510022685 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 101510022686 multimer interface [polypeptide binding]; other site 101510022687 active site 101510022688 catalytic triad [active] 101510022689 dimer interface [polypeptide binding]; other site 101510022690 Tubulin like; Region: Tubulin_2; pfam13809 101510022691 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510022692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510022693 High-affinity nickel-transport protein; Region: NicO; cl00964 101510022694 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 101510022695 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 101510022696 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 101510022697 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510022698 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510022699 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510022700 classical (c) SDRs; Region: SDR_c; cd05233 101510022701 NAD(P) binding site [chemical binding]; other site 101510022702 active site 101510022703 short chain dehydrogenase; Provisional; Region: PRK06172 101510022704 classical (c) SDRs; Region: SDR_c; cd05233 101510022705 NAD(P) binding site [chemical binding]; other site 101510022706 active site 101510022707 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 101510022708 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510022709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510022710 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 101510022711 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 101510022712 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510022713 CoA binding site [chemical binding]; other site 101510022714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510022715 AMP binding site [chemical binding]; other site 101510022716 EthD domain; Region: EthD; cl17553 101510022717 hypothetical protein; Validated; Region: PRK07581 101510022718 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 101510022719 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 101510022720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 101510022721 Helix-turn-helix domain; Region: HTH_38; pfam13936 101510022722 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 101510022723 Integrase core domain; Region: rve; pfam00665 101510022724 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510022725 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510022726 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510022727 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 101510022728 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 101510022729 putative active site [active] 101510022730 putative NTP binding site [chemical binding]; other site 101510022731 putative nucleic acid binding site [nucleotide binding]; other site 101510022732 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 101510022733 benzoate transport; Region: 2A0115; TIGR00895 101510022734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510022735 putative substrate translocation pore; other site 101510022736 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 101510022737 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510022738 catalytic loop [active] 101510022739 iron binding site [ion binding]; other site 101510022740 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 101510022741 FAD binding pocket [chemical binding]; other site 101510022742 FAD binding motif [chemical binding]; other site 101510022743 phosphate binding motif [ion binding]; other site 101510022744 beta-alpha-beta structure motif; other site 101510022745 NAD binding pocket [chemical binding]; other site 101510022746 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 101510022747 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 101510022748 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 101510022749 inter-subunit interface; other site 101510022750 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510022751 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510022752 iron-sulfur cluster [ion binding]; other site 101510022753 [2Fe-2S] cluster binding site [ion binding]; other site 101510022754 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 101510022755 putative alpha subunit interface [polypeptide binding]; other site 101510022756 putative active site [active] 101510022757 putative substrate binding site [chemical binding]; other site 101510022758 Fe binding site [ion binding]; other site 101510022759 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 101510022760 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 101510022761 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510022762 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 101510022763 NMT1/THI5 like; Region: NMT1; pfam09084 101510022764 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 101510022765 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 101510022766 Walker A/P-loop; other site 101510022767 ATP binding site [chemical binding]; other site 101510022768 Q-loop/lid; other site 101510022769 ABC transporter signature motif; other site 101510022770 Walker B; other site 101510022771 D-loop; other site 101510022772 H-loop/switch region; other site 101510022773 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510022774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510022775 dimer interface [polypeptide binding]; other site 101510022776 conserved gate region; other site 101510022777 putative PBP binding loops; other site 101510022778 ABC-ATPase subunit interface; other site 101510022779 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 101510022780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 101510022781 dimer interface [polypeptide binding]; other site 101510022782 conserved gate region; other site 101510022783 putative PBP binding loops; other site 101510022784 ABC-ATPase subunit interface; other site 101510022785 Isochorismatase family; Region: Isochorismatase; pfam00857 101510022786 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 101510022787 catalytic triad [active] 101510022788 substrate binding site [chemical binding]; other site 101510022789 domain interfaces; other site 101510022790 conserved cis-peptide bond; other site 101510022791 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 101510022792 Transcriptional regulator [Transcription]; Region: IclR; COG1414 101510022793 Bacterial transcriptional regulator; Region: IclR; pfam01614 101510022794 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 101510022795 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 101510022796 alpha subunit interaction site [polypeptide binding]; other site 101510022797 beta subunit interaction site [polypeptide binding]; other site 101510022798 iron-sulfur cluster [ion binding]; other site 101510022799 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 101510022800 beta subunit interface [polypeptide binding]; other site 101510022801 alpha subunit interface [polypeptide binding]; other site 101510022802 active site 101510022803 substrate binding site [chemical binding]; other site 101510022804 Fe binding site [ion binding]; other site 101510022805 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 101510022806 inter-subunit interface; other site 101510022807 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 101510022808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022809 NAD(P) binding site [chemical binding]; other site 101510022810 active site 101510022811 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510022812 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510022813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510022814 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 101510022815 intersubunit interface [polypeptide binding]; other site 101510022816 active site 101510022817 Zn2+ binding site [ion binding]; other site 101510022818 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 101510022819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 101510022820 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 101510022821 Integrase core domain; Region: rve; pfam00665 101510022822 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 101510022823 Prostaglandin dehydrogenases; Region: PGDH; cd05288 101510022824 NAD(P) binding site [chemical binding]; other site 101510022825 substrate binding site [chemical binding]; other site 101510022826 dimer interface [polypeptide binding]; other site 101510022827 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 101510022828 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 101510022829 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 101510022830 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510022831 substrate binding pocket [chemical binding]; other site 101510022832 Cupin domain; Region: Cupin_2; pfam07883 101510022833 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 101510022834 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 101510022835 tetrameric interface [polypeptide binding]; other site 101510022836 NAD binding site [chemical binding]; other site 101510022837 catalytic residues [active] 101510022838 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510022839 active site 101510022840 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510022841 classical (c) SDRs; Region: SDR_c; cd05233 101510022842 NAD(P) binding site [chemical binding]; other site 101510022843 active site 101510022844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510022845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510022846 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 101510022847 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 101510022848 acyl-activating enzyme (AAE) consensus motif; other site 101510022849 putative AMP binding site [chemical binding]; other site 101510022850 putative active site [active] 101510022851 putative CoA binding site [chemical binding]; other site 101510022852 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510022853 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510022854 active site 101510022855 ATP binding site [chemical binding]; other site 101510022856 substrate binding site [chemical binding]; other site 101510022857 activation loop (A-loop); other site 101510022858 Predicted ATPase [General function prediction only]; Region: COG3903 101510022859 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510022860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510022861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510022862 DNA binding residues [nucleotide binding] 101510022863 dimerization interface [polypeptide binding]; other site 101510022864 Uncharacterized conserved protein [Function unknown]; Region: COG3268 101510022865 Uncharacterized conserved protein [Function unknown]; Region: COG3268 101510022866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510022867 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510022868 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510022869 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510022870 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510022871 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510022872 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 101510022873 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 101510022874 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 101510022875 Transposase domain (DUF772); Region: DUF772; pfam05598 101510022876 putative transposase OrfB; Reviewed; Region: PHA02517 101510022877 HTH-like domain; Region: HTH_21; pfam13276 101510022878 Integrase core domain; Region: rve; pfam00665 101510022879 Integrase core domain; Region: rve_3; pfam13683 101510022880 Transposase; Region: HTH_Tnp_1; cl17663 101510022881 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 101510022882 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510022883 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 101510022884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510022885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510022886 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510022887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510022888 putative substrate translocation pore; other site 101510022889 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 101510022890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022891 NAD(P) binding site [chemical binding]; other site 101510022892 active site 101510022893 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 101510022894 short chain dehydrogenase; Provisional; Region: PRK08303 101510022895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022896 NAD(P) binding site [chemical binding]; other site 101510022897 active site 101510022898 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 101510022899 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510022900 putative NAD(P) binding site [chemical binding]; other site 101510022901 catalytic Zn binding site [ion binding]; other site 101510022902 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510022903 MULE transposase domain; Region: MULE; pfam10551 101510022904 putative transposase OrfB; Reviewed; Region: PHA02517 101510022905 HTH-like domain; Region: HTH_21; pfam13276 101510022906 Integrase core domain; Region: rve; pfam00665 101510022907 Integrase core domain; Region: rve_3; pfam13683 101510022908 Transposase; Region: HTH_Tnp_1; cl17663 101510022909 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 101510022910 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 101510022911 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510022912 active site 101510022913 catalytic residues [active] 101510022914 DNA binding site [nucleotide binding] 101510022915 Int/Topo IB signature motif; other site 101510022916 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510022917 active site 101510022918 catalytic residues [active] 101510022919 DNA binding site [nucleotide binding] 101510022920 Int/Topo IB signature motif; other site 101510022921 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510022922 DoxX; Region: DoxX; pfam07681 101510022923 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510022924 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 101510022925 phosphate binding site [ion binding]; other site 101510022926 SnoaL-like domain; Region: SnoaL_3; pfam13474 101510022927 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 101510022928 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 101510022929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510022930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510022931 putative substrate translocation pore; other site 101510022932 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510022933 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510022934 FMN-binding pocket [chemical binding]; other site 101510022935 flavin binding motif; other site 101510022936 phosphate binding motif [ion binding]; other site 101510022937 beta-alpha-beta structure motif; other site 101510022938 NAD binding pocket [chemical binding]; other site 101510022939 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510022940 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510022941 catalytic loop [active] 101510022942 iron binding site [ion binding]; other site 101510022943 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 101510022944 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 101510022945 iron-sulfur cluster [ion binding]; other site 101510022946 [2Fe-2S] cluster binding site [ion binding]; other site 101510022947 Amidohydrolase; Region: Amidohydro_2; pfam04909 101510022948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510022949 transcriptional regulator NanR; Provisional; Region: PRK03837 101510022950 DNA-binding site [nucleotide binding]; DNA binding site 101510022951 FCD domain; Region: FCD; pfam07729 101510022952 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510022953 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 101510022954 FAD binding domain; Region: FAD_binding_4; pfam01565 101510022955 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 101510022956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510022957 NAD(P) binding site [chemical binding]; other site 101510022958 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510022959 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510022960 acyl-activating enzyme (AAE) consensus motif; other site 101510022961 AMP binding site [chemical binding]; other site 101510022962 active site 101510022963 CoA binding site [chemical binding]; other site 101510022964 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 101510022965 classical (c) SDRs; Region: SDR_c; cd05233 101510022966 NAD(P) binding site [chemical binding]; other site 101510022967 active site 101510022968 acyl-CoA synthetase; Validated; Region: PRK07798 101510022969 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510022970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510022971 acyl-activating enzyme (AAE) consensus motif; other site 101510022972 acyl-activating enzyme (AAE) consensus motif; other site 101510022973 AMP binding site [chemical binding]; other site 101510022974 active site 101510022975 CoA binding site [chemical binding]; other site 101510022976 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 101510022977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510022978 acyl-activating enzyme (AAE) consensus motif; other site 101510022979 AMP binding site [chemical binding]; other site 101510022980 active site 101510022981 CoA binding site [chemical binding]; other site 101510022982 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510022983 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510022984 NAD(P) binding site [chemical binding]; other site 101510022985 catalytic residues [active] 101510022986 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 101510022987 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510022988 MULE transposase domain; Region: MULE; pfam10551 101510022989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510022990 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 101510022991 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 101510022992 active site 101510022993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510022994 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 101510022995 active site 101510022996 Amidohydrolase; Region: Amidohydro_2; pfam04909 101510022997 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 101510022998 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510022999 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 101510023000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510023001 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 101510023002 Beta-lactamase; Region: Beta-lactamase; pfam00144 101510023003 enoyl-CoA hydratase; Provisional; Region: PRK08290 101510023004 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510023005 substrate binding site [chemical binding]; other site 101510023006 oxyanion hole (OAH) forming residues; other site 101510023007 trimer interface [polypeptide binding]; other site 101510023008 FAD binding domain; Region: FAD_binding_3; pfam01494 101510023009 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510023010 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 101510023011 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 101510023012 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 101510023013 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 101510023014 active site 101510023015 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 101510023016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 101510023017 putative active site [active] 101510023018 putative metal binding site [ion binding]; other site 101510023019 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510023020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510023021 substrate binding site [chemical binding]; other site 101510023022 oxyanion hole (OAH) forming residues; other site 101510023023 trimer interface [polypeptide binding]; other site 101510023024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 101510023025 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510023026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510023027 NAD(P) binding site [chemical binding]; other site 101510023028 active site 101510023029 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 101510023030 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 101510023031 dimer interface [polypeptide binding]; other site 101510023032 active site 101510023033 enoyl-CoA hydratase; Provisional; Region: PRK08252 101510023034 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510023035 substrate binding site [chemical binding]; other site 101510023036 oxyanion hole (OAH) forming residues; other site 101510023037 trimer interface [polypeptide binding]; other site 101510023038 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510023039 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 101510023040 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 101510023041 putative ligand binding site [chemical binding]; other site 101510023042 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510023043 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 101510023044 TM-ABC transporter signature motif; other site 101510023045 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 101510023046 TM-ABC transporter signature motif; other site 101510023047 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 101510023048 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 101510023049 Walker A/P-loop; other site 101510023050 ATP binding site [chemical binding]; other site 101510023051 Q-loop/lid; other site 101510023052 ABC transporter signature motif; other site 101510023053 Walker B; other site 101510023054 D-loop; other site 101510023055 H-loop/switch region; other site 101510023056 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 101510023057 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 101510023058 Walker A/P-loop; other site 101510023059 ATP binding site [chemical binding]; other site 101510023060 Q-loop/lid; other site 101510023061 ABC transporter signature motif; other site 101510023062 Walker B; other site 101510023063 D-loop; other site 101510023064 H-loop/switch region; other site 101510023065 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 101510023066 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 101510023067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510023068 NAD(P) binding site [chemical binding]; other site 101510023069 active site 101510023070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510023071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510023072 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 101510023073 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510023074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510023075 DNA-binding site [nucleotide binding]; DNA binding site 101510023076 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 101510023077 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510023078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510023079 DNA-binding site [nucleotide binding]; DNA binding site 101510023080 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510023081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510023082 active site 101510023083 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510023084 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510023085 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510023086 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 101510023087 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510023088 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 101510023089 CoenzymeA binding site [chemical binding]; other site 101510023090 subunit interaction site [polypeptide binding]; other site 101510023091 PHB binding site; other site 101510023092 Amidohydrolase; Region: Amidohydro_2; pfam04909 101510023093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510023094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510023095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510023096 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 101510023097 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 101510023098 putative active site [active] 101510023099 putative CoA binding site [chemical binding]; other site 101510023100 nudix motif; other site 101510023101 metal binding site [ion binding]; metal-binding site 101510023102 lipid-transfer protein; Provisional; Region: PRK07855 101510023103 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510023104 active site 101510023105 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510023106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510023107 DNA-binding site [nucleotide binding]; DNA binding site 101510023108 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 101510023109 Transcriptional regulators [Transcription]; Region: FadR; COG2186 101510023110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510023111 DNA-binding site [nucleotide binding]; DNA binding site 101510023112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510023113 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 101510023114 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 101510023115 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 101510023116 GTP cyclohydrolase I; Provisional; Region: PLN03044 101510023117 homodecamer interface [polypeptide binding]; other site 101510023118 active site 101510023119 putative catalytic site residues [active] 101510023120 zinc binding site [ion binding]; other site 101510023121 GTP-CH-I/GFRP interaction surface; other site 101510023122 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 101510023123 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510023124 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510023125 DoxX; Region: DoxX; cl17842 101510023126 classical (c) SDRs; Region: SDR_c; cd05233 101510023127 NAD(P) binding site [chemical binding]; other site 101510023128 active site 101510023129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510023130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510023131 active site 101510023132 short chain dehydrogenase; Provisional; Region: PRK07035 101510023133 classical (c) SDRs; Region: SDR_c; cd05233 101510023134 NAD(P) binding site [chemical binding]; other site 101510023135 active site 101510023136 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 101510023137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510023138 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 101510023139 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 101510023140 Phosphotransferase enzyme family; Region: APH; pfam01636 101510023141 putative active site [active] 101510023142 putative substrate binding site [chemical binding]; other site 101510023143 ATP binding site [chemical binding]; other site 101510023144 putative transposase OrfB; Reviewed; Region: PHA02517 101510023145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510023146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510023147 active site 101510023148 ATP binding site [chemical binding]; other site 101510023149 substrate binding site [chemical binding]; other site 101510023150 activation loop (A-loop); other site 101510023151 AAA ATPase domain; Region: AAA_16; pfam13191 101510023152 Predicted ATPase [General function prediction only]; Region: COG3903 101510023153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510023154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510023155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510023156 DNA binding residues [nucleotide binding] 101510023157 dimerization interface [polypeptide binding]; other site 101510023158 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510023159 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 101510023160 putative NAD(P) binding site [chemical binding]; other site 101510023161 catalytic Zn binding site [ion binding]; other site 101510023162 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510023163 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 101510023164 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 101510023165 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 101510023166 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 101510023167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510023168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510023169 putative substrate translocation pore; other site 101510023170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510023171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510023172 Helix-turn-helix domain; Region: HTH_17; pfam12728 101510023173 PIN domain; Region: PIN_3; pfam13470 101510023174 Lsr2; Region: Lsr2; pfam11774 101510023175 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 101510023176 homodimer interface [polypeptide binding]; other site 101510023177 putative active site [active] 101510023178 catalytic site [active] 101510023179 DDE superfamily endonuclease; Region: DDE_5; pfam13546 101510023180 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510023181 MULE transposase domain; Region: MULE; pfam10551 101510023182 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510023183 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510023184 active site 101510023185 ATP binding site [chemical binding]; other site 101510023186 substrate binding site [chemical binding]; other site 101510023187 activation loop (A-loop); other site 101510023188 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 101510023189 AAA ATPase domain; Region: AAA_16; pfam13191 101510023190 Predicted ATPase [General function prediction only]; Region: COG3903 101510023191 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510023192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510023193 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510023194 DNA binding residues [nucleotide binding] 101510023195 dimerization interface [polypeptide binding]; other site 101510023196 Helix-turn-helix domain; Region: HTH_17; cl17695 101510023197 RES domain; Region: RES; pfam08808 101510023198 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 101510023199 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 101510023200 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 101510023201 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 101510023202 ATP-grasp domain; Region: ATP-grasp_4; cl17255 101510023203 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 101510023204 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 101510023205 carboxyltransferase (CT) interaction site; other site 101510023206 biotinylation site [posttranslational modification]; other site 101510023207 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 101510023208 putative active site [active] 101510023209 acyl-CoA synthetase; Validated; Region: PRK08162 101510023210 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 101510023211 acyl-activating enzyme (AAE) consensus motif; other site 101510023212 putative active site [active] 101510023213 AMP binding site [chemical binding]; other site 101510023214 putative CoA binding site [chemical binding]; other site 101510023215 Putative cyclase; Region: Cyclase; pfam04199 101510023216 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510023217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510023218 DNA-binding site [nucleotide binding]; DNA binding site 101510023219 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 101510023220 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 101510023221 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 101510023222 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 101510023223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 101510023224 PAS domain; Region: PAS_9; pfam13426 101510023225 putative active site [active] 101510023226 heme pocket [chemical binding]; other site 101510023227 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 101510023228 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 101510023229 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 101510023230 active site 101510023231 ATP binding site [chemical binding]; other site 101510023232 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 101510023233 substrate binding site [chemical binding]; other site 101510023234 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 101510023235 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 101510023236 putative catalytic cysteine [active] 101510023237 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 101510023238 Hexamer interface [polypeptide binding]; other site 101510023239 Hexagonal pore residue; other site 101510023240 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 101510023241 putative hexamer interface [polypeptide binding]; other site 101510023242 putative hexagonal pore; other site 101510023243 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 101510023244 Hexamer/Pentamer interface [polypeptide binding]; other site 101510023245 central pore; other site 101510023246 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 101510023247 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 101510023248 Hexamer interface [polypeptide binding]; other site 101510023249 Hexagonal pore residue; other site 101510023250 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 101510023251 putative hexamer interface [polypeptide binding]; other site 101510023252 putative hexagonal pore; other site 101510023253 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 101510023254 putative hexamer interface [polypeptide binding]; other site 101510023255 putative hexagonal pore; other site 101510023256 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 101510023257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 101510023258 inhibitor-cofactor binding pocket; inhibition site 101510023259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 101510023260 catalytic residue [active] 101510023261 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 101510023262 Hexamer interface [polypeptide binding]; other site 101510023263 Hexagonal pore residue; other site 101510023264 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 101510023265 putative hexamer interface [polypeptide binding]; other site 101510023266 putative hexagonal pore; other site 101510023267 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 101510023268 Hexamer/Pentamer interface [polypeptide binding]; other site 101510023269 central pore; other site 101510023270 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 101510023271 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 101510023272 Hexamer interface [polypeptide binding]; other site 101510023273 Hexagonal pore residue; other site 101510023274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510023275 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 101510023276 DNA-binding site [nucleotide binding]; DNA binding site 101510023277 UTRA domain; Region: UTRA; pfam07702 101510023278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510023279 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 101510023280 substrate binding site [chemical binding]; other site 101510023281 oxyanion hole (OAH) forming residues; other site 101510023282 trimer interface [polypeptide binding]; other site 101510023283 ethanolamine permease; Region: 2A0305; TIGR00908 101510023284 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 101510023285 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 101510023286 conserved cys residue [active] 101510023287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510023288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510023289 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 101510023290 Isochorismatase family; Region: Isochorismatase; pfam00857 101510023291 catalytic triad [active] 101510023292 conserved cis-peptide bond; other site 101510023293 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 101510023294 conserved cis-peptide bond; other site 101510023295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510023296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510023297 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 101510023298 putative dimerization interface [polypeptide binding]; other site 101510023299 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 101510023300 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 101510023301 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 101510023302 active site 101510023303 Creatinine amidohydrolase; Region: Creatininase; pfam02633 101510023304 metabolite-proton symporter; Region: 2A0106; TIGR00883 101510023305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510023306 putative substrate translocation pore; other site 101510023307 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 101510023308 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 101510023309 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 101510023310 catalytic residue [active] 101510023311 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 101510023312 homotrimer interaction site [polypeptide binding]; other site 101510023313 putative active site [active] 101510023314 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510023315 DNA binding site [nucleotide binding] 101510023316 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 101510023317 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 101510023318 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 101510023319 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 101510023320 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 101510023321 Active Sites [active] 101510023322 Helix-turn-helix domain; Region: HTH_36; pfam13730 101510023323 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 101510023324 CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865 101510023325 CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cl11864 101510023326 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 101510023327 Active Sites [active] 101510023328 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 101510023329 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 101510023330 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 101510023331 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 101510023332 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 101510023333 AsnC family; Region: AsnC_trans_reg; pfam01037 101510023334 LysE type translocator; Region: LysE; cl00565 101510023335 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 101510023336 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510023337 acyl-activating enzyme (AAE) consensus motif; other site 101510023338 AMP binding site [chemical binding]; other site 101510023339 active site 101510023340 CoA binding site [chemical binding]; other site 101510023341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510023342 active site 101510023343 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 101510023344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 101510023345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510023346 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 101510023347 putative transposase OrfB; Reviewed; Region: PHA02517 101510023348 HTH-like domain; Region: HTH_21; pfam13276 101510023349 Integrase core domain; Region: rve; pfam00665 101510023350 Integrase core domain; Region: rve_3; pfam13683 101510023351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 101510023352 Transposase; Region: HTH_Tnp_1; cl17663 101510023353 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 101510023354 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 101510023355 NAD(P) binding site [chemical binding]; other site 101510023356 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 101510023357 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 101510023358 E3 interaction surface; other site 101510023359 lipoyl attachment site [posttranslational modification]; other site 101510023360 e3 binding domain; Region: E3_binding; pfam02817 101510023361 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 101510023362 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 101510023363 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 101510023364 alpha subunit interface [polypeptide binding]; other site 101510023365 TPP binding site [chemical binding]; other site 101510023366 heterodimer interface [polypeptide binding]; other site 101510023367 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 101510023368 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 101510023369 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 101510023370 tetramer interface [polypeptide binding]; other site 101510023371 TPP-binding site [chemical binding]; other site 101510023372 heterodimer interface [polypeptide binding]; other site 101510023373 phosphorylation loop region [posttranslational modification] 101510023374 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510023375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510023376 active site 101510023377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510023378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510023379 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 101510023380 GAF domain; Region: GAF; pfam01590 101510023381 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 101510023382 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510023383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510023384 substrate binding site [chemical binding]; other site 101510023385 oxyanion hole (OAH) forming residues; other site 101510023386 trimer interface [polypeptide binding]; other site 101510023387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 101510023388 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 101510023389 NAD(P) binding site [chemical binding]; other site 101510023390 homodimer interface [polypeptide binding]; other site 101510023391 active site 101510023392 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510023393 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 101510023394 FO synthase; Reviewed; Region: fbiC; PRK09234 101510023395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510023396 FeS/SAM binding site; other site 101510023397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 101510023398 FeS/SAM binding site; other site 101510023399 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510023400 classical (c) SDRs; Region: SDR_c; cd05233 101510023401 NAD(P) binding site [chemical binding]; other site 101510023402 active site 101510023403 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 101510023404 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 101510023405 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510023406 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 101510023407 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 101510023408 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 101510023409 dimerization interface [polypeptide binding]; other site 101510023410 Domain of unknown function (DUF385); Region: DUF385; pfam04075 101510023411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510023412 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 101510023413 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 101510023414 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510023415 NAD(P) binding site [chemical binding]; other site 101510023416 catalytic residues [active] 101510023417 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510023418 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510023419 active site 101510023420 ATP binding site [chemical binding]; other site 101510023421 substrate binding site [chemical binding]; other site 101510023422 activation loop (A-loop); other site 101510023423 AAA ATPase domain; Region: AAA_16; pfam13191 101510023424 Predicted ATPase [General function prediction only]; Region: COG3903 101510023425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 101510023426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510023427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510023428 DNA binding residues [nucleotide binding] 101510023429 dimerization interface [polypeptide binding]; other site 101510023430 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 101510023431 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 101510023432 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 101510023433 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510023434 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 101510023435 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 101510023436 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510023437 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 101510023438 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 101510023439 active site 101510023440 dimer interface [polypeptide binding]; other site 101510023441 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 101510023442 dimer interface [polypeptide binding]; other site 101510023443 active site 101510023444 Transcription factor WhiB; Region: Whib; pfam02467 101510023445 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 101510023446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 101510023447 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 101510023448 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510023449 catalytic loop [active] 101510023450 iron binding site [ion binding]; other site 101510023451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510023452 Cytochrome P450; Region: p450; cl12078 101510023453 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 101510023454 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 101510023455 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 101510023456 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 101510023457 active site 101510023458 catalytic triad [active] 101510023459 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 101510023460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510023461 Walker A motif; other site 101510023462 ATP binding site [chemical binding]; other site 101510023463 Walker B motif; other site 101510023464 arginine finger; other site 101510023465 acyl carrier protein; Provisional; Region: acpP; PRK00982 101510023466 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 101510023467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 101510023468 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 101510023469 homodimer interface [polypeptide binding]; other site 101510023470 putative active site [active] 101510023471 catalytic site [active] 101510023472 Lsr2; Region: Lsr2; pfam11774 101510023473 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 101510023474 Lsr2; Region: Lsr2; pfam11774 101510023475 Lsr2; Region: Lsr2; pfam11774 101510023476 Lsr2; Region: Lsr2; pfam11774 101510023477 glycoprotein BALF4; Provisional; Region: PHA03231 101510023478 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 101510023479 nucleophile elbow; other site 101510023480 MULE transposase domain; Region: MULE; pfam10551 101510023481 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 101510023482 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 101510023483 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510023484 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510023485 phosphopeptide binding site; other site 101510023486 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 101510023487 putative active site [active] 101510023488 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510023489 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510023490 phosphopeptide binding site; other site 101510023491 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 101510023492 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510023493 Walker A/P-loop; other site 101510023494 ATP binding site [chemical binding]; other site 101510023495 Q-loop/lid; other site 101510023496 ABC transporter signature motif; other site 101510023497 Walker B; other site 101510023498 D-loop; other site 101510023499 H-loop/switch region; other site 101510023500 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 101510023501 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 101510023502 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510023503 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510023504 active site 101510023505 ATP binding site [chemical binding]; other site 101510023506 substrate binding site [chemical binding]; other site 101510023507 activation loop (A-loop); other site 101510023508 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 101510023509 MarR family; Region: MarR; pfam01047 101510023510 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 101510023511 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510023512 active site 101510023513 ATP binding site [chemical binding]; other site 101510023514 substrate binding site [chemical binding]; other site 101510023515 activation loop (A-loop); other site 101510023516 Uncharacterized conserved protein [Function unknown]; Region: COG3391 101510023517 NHL repeat; Region: NHL; pfam01436 101510023518 NHL repeat; Region: NHL; pfam01436 101510023519 NHL repeat; Region: NHL; pfam01436 101510023520 Protein of unknown function (DUF732); Region: DUF732; pfam05305 101510023521 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510023522 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 101510023523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 101510023524 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 101510023525 PIN domain; Region: PIN_3; pfam13470 101510023526 Helix-turn-helix domain; Region: HTH_17; pfam12728 101510023527 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 101510023528 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 101510023529 AAA ATPase domain; Region: AAA_16; pfam13191 101510023530 Winged helix-turn helix; Region: HTH_29; pfam13551 101510023531 Helix-turn-helix domain; Region: HTH_28; pfam13518 101510023532 Homeodomain-like domain; Region: HTH_32; pfam13565 101510023533 Integrase core domain; Region: rve; pfam00665 101510023534 Integrase core domain; Region: rve_3; cl15866 101510023535 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 101510023536 Homeodomain-like domain; Region: HTH_23; pfam13384 101510023537 Winged helix-turn helix; Region: HTH_29; pfam13551 101510023538 Homeodomain-like domain; Region: HTH_32; pfam13565 101510023539 DDE superfamily endonuclease; Region: DDE_3; pfam13358 101510023540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 101510023541 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 101510023542 active site 101510023543 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 101510023544 DNA binding site [nucleotide binding] 101510023545 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 101510023546 Transposase; Region: DEDD_Tnp_IS110; pfam01548 101510023547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 101510023548 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 101510023549 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 101510023550 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 101510023551 ParB-like nuclease domain; Region: ParBc; cl02129 101510023552 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 101510023553 LGFP repeat; Region: LGFP; pfam08310 101510023554 LGFP repeat; Region: LGFP; pfam08310 101510023555 LGFP repeat; Region: LGFP; pfam08310 101510023556 LGFP repeat; Region: LGFP; pfam08310 101510023557 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 101510023558 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 101510023559 active site 101510023560 catalytic residues [active] 101510023561 DNA binding site [nucleotide binding] 101510023562 Int/Topo IB signature motif; other site 101510023563 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 101510023564 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 101510023565 active site 101510023566 DNA binding site [nucleotide binding] 101510023567 Int/Topo IB signature motif; other site 101510023568 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 101510023569 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 101510023570 active site 101510023571 DNA binding site [nucleotide binding] 101510023572 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 101510023573 DNA binding site [nucleotide binding] 101510023574 HsdM N-terminal domain; Region: HsdM_N; pfam12161 101510023575 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 101510023576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510023577 S-adenosylmethionine binding site [chemical binding]; other site 101510023578 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 101510023579 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 101510023580 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 101510023581 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 101510023582 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 101510023583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 101510023584 ATP binding site [chemical binding]; other site 101510023585 putative Mg++ binding site [ion binding]; other site 101510023586 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 101510023587 AAA domain; Region: AAA_21; pfam13304 101510023588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510023589 ABC transporter signature motif; other site 101510023590 Walker B; other site 101510023591 D-loop; other site 101510023592 H-loop/switch region; other site 101510023593 Transposase; Region: HTH_Tnp_1; cl17663 101510023594 HTH-like domain; Region: HTH_21; pfam13276 101510023595 Integrase core domain; Region: rve_3; cl15866 101510023596 Transcription factor WhiB; Region: Whib; pfam02467 101510023597 acyl-CoA synthetase; Validated; Region: PRK08162 101510023598 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 101510023599 acyl-activating enzyme (AAE) consensus motif; other site 101510023600 putative active site [active] 101510023601 AMP binding site [chemical binding]; other site 101510023602 putative CoA binding site [chemical binding]; other site 101510023603 YCII-related domain; Region: YCII; cl00999 101510023604 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 101510023605 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 101510023606 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510023607 classical (c) SDRs; Region: SDR_c; cd05233 101510023608 NAD(P) binding site [chemical binding]; other site 101510023609 active site 101510023610 Cupin domain; Region: Cupin_2; pfam07883 101510023611 Cupin domain; Region: Cupin_2; cl17218 101510023612 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 101510023613 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 101510023614 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 101510023615 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 101510023616 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 101510023617 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 101510023618 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 101510023619 active site 101510023620 dimer interface [polypeptide binding]; other site 101510023621 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 101510023622 dimer interface [polypeptide binding]; other site 101510023623 active site 101510023624 acyl-CoA synthetase; Validated; Region: PRK07470 101510023625 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 101510023626 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 101510023627 acyl-activating enzyme (AAE) consensus motif; other site 101510023628 putative AMP binding site [chemical binding]; other site 101510023629 putative active site [active] 101510023630 putative CoA binding site [chemical binding]; other site 101510023631 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 101510023632 classical (c) SDRs; Region: SDR_c; cd05233 101510023633 NAD(P) binding site [chemical binding]; other site 101510023634 active site 101510023635 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 101510023636 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 101510023637 NAD binding site [chemical binding]; other site 101510023638 catalytic Zn binding site [ion binding]; other site 101510023639 substrate binding site [chemical binding]; other site 101510023640 structural Zn binding site [ion binding]; other site 101510023641 hypothetical protein; Provisional; Region: PRK06126 101510023642 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510023643 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 101510023644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510023645 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 101510023646 putative substrate translocation pore; other site 101510023647 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 101510023648 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 101510023649 TM-ABC transporter signature motif; other site 101510023650 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 101510023651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 101510023652 Walker A/P-loop; other site 101510023653 ATP binding site [chemical binding]; other site 101510023654 Q-loop/lid; other site 101510023655 ABC transporter signature motif; other site 101510023656 Walker B; other site 101510023657 D-loop; other site 101510023658 H-loop/switch region; other site 101510023659 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 101510023660 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 101510023661 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 101510023662 ligand binding site [chemical binding]; other site 101510023663 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 101510023664 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 101510023665 NAD binding site [chemical binding]; other site 101510023666 catalytic residues [active] 101510023667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510023668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510023669 Coenzyme A transferase; Region: CoA_trans; cl17247 101510023670 Coenzyme A transferase; Region: CoA_trans; cl17247 101510023671 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 101510023672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 101510023673 NAD(P) binding site [chemical binding]; other site 101510023674 active site 101510023675 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510023676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510023677 substrate binding site [chemical binding]; other site 101510023678 oxyanion hole (OAH) forming residues; other site 101510023679 trimer interface [polypeptide binding]; other site 101510023680 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 101510023681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 101510023682 substrate binding site [chemical binding]; other site 101510023683 oxyanion hole (OAH) forming residues; other site 101510023684 trimer interface [polypeptide binding]; other site 101510023685 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510023686 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510023687 active site 101510023688 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 101510023689 DUF35 OB-fold domain; Region: DUF35; pfam01796 101510023690 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 101510023691 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 101510023692 active site 101510023693 Transcriptional regulators [Transcription]; Region: GntR; COG1802 101510023694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 101510023695 DNA-binding site [nucleotide binding]; DNA binding site 101510023696 FCD domain; Region: FCD; pfam07729 101510023697 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 101510023698 CoA-transferase family III; Region: CoA_transf_3; pfam02515 101510023699 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 101510023700 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 101510023701 acyl-activating enzyme (AAE) consensus motif; other site 101510023702 putative AMP binding site [chemical binding]; other site 101510023703 putative active site [active] 101510023704 putative CoA binding site [chemical binding]; other site 101510023705 acetyl-CoA synthetase; Provisional; Region: PRK00174 101510023706 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 101510023707 active site 101510023708 CoA binding site [chemical binding]; other site 101510023709 acyl-activating enzyme (AAE) consensus motif; other site 101510023710 AMP binding site [chemical binding]; other site 101510023711 acetate binding site [chemical binding]; other site 101510023712 multiple promoter invertase; Provisional; Region: mpi; PRK13413 101510023713 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 101510023714 catalytic residues [active] 101510023715 catalytic nucleophile [active] 101510023716 Presynaptic Site I dimer interface [polypeptide binding]; other site 101510023717 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 101510023718 Synaptic Flat tetramer interface [polypeptide binding]; other site 101510023719 Synaptic Site I dimer interface [polypeptide binding]; other site 101510023720 DNA binding site [nucleotide binding] 101510023721 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 101510023722 DNA-binding interface [nucleotide binding]; DNA binding site 101510023723 Clp amino terminal domain; Region: Clp_N; pfam02861 101510023724 Clp amino terminal domain; Region: Clp_N; pfam02861 101510023725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 101510023726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 101510023727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 101510023728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 101510023729 S-adenosylmethionine binding site [chemical binding]; other site 101510023730 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 101510023731 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 101510023732 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 101510023733 Multicopper oxidase; Region: Cu-oxidase; pfam00394 101510023734 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 101510023735 Predicted membrane protein [Function unknown]; Region: COG3462 101510023736 Short C-terminal domain; Region: SHOCT; pfam09851 101510023737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 101510023738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 101510023739 active site 101510023740 phosphorylation site [posttranslational modification] 101510023741 intermolecular recognition site; other site 101510023742 dimerization interface [polypeptide binding]; other site 101510023743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 101510023744 DNA binding site [nucleotide binding] 101510023745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 101510023746 dimer interface [polypeptide binding]; other site 101510023747 phosphorylation site [posttranslational modification] 101510023748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 101510023749 ATP binding site [chemical binding]; other site 101510023750 Mg2+ binding site [ion binding]; other site 101510023751 G-X-G motif; other site 101510023752 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 101510023753 metal-binding site [ion binding] 101510023754 Domain of unknown function (DUF305); Region: DUF305; pfam03713 101510023755 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 101510023756 putative homodimer interface [polypeptide binding]; other site 101510023757 putative homotetramer interface [polypeptide binding]; other site 101510023758 putative allosteric switch controlling residues; other site 101510023759 putative metal binding site [ion binding]; other site 101510023760 putative homodimer-homodimer interface [polypeptide binding]; other site 101510023761 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 101510023762 metal-binding site [ion binding] 101510023763 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 101510023764 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510023765 Soluble P-type ATPase [General function prediction only]; Region: COG4087 101510023766 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 101510023767 metal-binding site [ion binding] 101510023768 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 101510023769 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 101510023770 metal-binding site [ion binding] 101510023771 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 101510023772 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 101510023773 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 101510023774 Walker A/P-loop; other site 101510023775 ATP binding site [chemical binding]; other site 101510023776 Q-loop/lid; other site 101510023777 ABC transporter signature motif; other site 101510023778 Walker B; other site 101510023779 D-loop; other site 101510023780 H-loop/switch region; other site 101510023781 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 101510023782 hydrophobic ligand binding site; other site 101510023783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 101510023784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 101510023785 putative substrate translocation pore; other site 101510023786 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 101510023787 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510023788 active site residue [active] 101510023789 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510023790 active site residue [active] 101510023791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510023792 dimerization interface [polypeptide binding]; other site 101510023793 putative DNA binding site [nucleotide binding]; other site 101510023794 putative Zn2+ binding site [ion binding]; other site 101510023795 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510023796 active site residue [active] 101510023797 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 101510023798 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 101510023799 phosphopeptide binding site; other site 101510023800 Domain of unknown function DUF59; Region: DUF59; pfam01883 101510023801 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 101510023802 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 101510023803 Walker A motif; other site 101510023804 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 101510023805 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 101510023806 molybdopterin cofactor binding site; other site 101510023807 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 101510023808 putative molybdopterin cofactor binding site; other site 101510023809 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 101510023810 4Fe-4S binding domain; Region: Fer4; pfam00037 101510023811 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 101510023812 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 101510023813 CPxP motif; other site 101510023814 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 101510023815 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 101510023816 active site residue [active] 101510023817 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 101510023818 Domain of unknown function (DUF202); Region: DUF202; cl09954 101510023819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 101510023820 dimerization interface [polypeptide binding]; other site 101510023821 putative DNA binding site [nucleotide binding]; other site 101510023822 putative Zn2+ binding site [ion binding]; other site 101510023823 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 101510023824 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510023825 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510023826 active site residue [active] 101510023827 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 101510023828 catalytic residues [active] 101510023829 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 101510023830 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510023831 active site residue [active] 101510023832 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 101510023833 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 101510023834 putative homotetramer interface [polypeptide binding]; other site 101510023835 putative homodimer interface [polypeptide binding]; other site 101510023836 putative allosteric switch controlling residues; other site 101510023837 putative metal binding site [ion binding]; other site 101510023838 putative homodimer-homodimer interface [polypeptide binding]; other site 101510023839 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 101510023840 Domain of unknown function DUF302; Region: DUF302; pfam03625 101510023841 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 101510023842 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 101510023843 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 101510023844 active site residue [active] 101510023845 putative transporter; Provisional; Region: PRK11660 101510023846 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 101510023847 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 101510023848 putative NAD(P) binding site [chemical binding]; other site 101510023849 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 101510023850 PLD-like domain; Region: PLDc_2; pfam13091 101510023851 homodimer interface [polypeptide binding]; other site 101510023852 putative active site [active] 101510023853 catalytic site [active] 101510023854 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 101510023855 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 101510023856 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510023857 P-loop; other site 101510023858 Magnesium ion binding site [ion binding]; other site 101510023859 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 101510023860 Magnesium ion binding site [ion binding]; other site 101510023861 Transposase, Mutator family; Region: Transposase_mut; pfam00872 101510023862 MULE transposase domain; Region: MULE; pfam10551 101510023863 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 101510023864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510023865 non-specific DNA binding site [nucleotide binding]; other site 101510023866 salt bridge; other site 101510023867 sequence-specific DNA binding site [nucleotide binding]; other site 101510023868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 101510023869 salt bridge; other site 101510023870 non-specific DNA binding site [nucleotide binding]; other site 101510023871 sequence-specific DNA binding site [nucleotide binding]; other site 101510023872 Intracellular septation protein A; Region: IspA; pfam04279 101510023873 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510023874 Cytochrome P450; Region: p450; cl12078 101510023875 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 101510023876 TniQ; Region: TniQ; pfam06527 101510023877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 101510023878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 101510023879 Predicted transcriptional regulators [Transcription]; Region: COG1695 101510023880 Transcriptional regulator PadR-like family; Region: PadR; cl17335 101510023881 AAA domain; Region: AAA_22; pfam13401 101510023882 Bacterial TniB protein; Region: TniB; pfam05621 101510023883 Winged helix-turn helix; Region: HTH_29; pfam13551 101510023884 Helix-turn-helix domain; Region: HTH_28; pfam13518 101510023885 Integrase core domain; Region: rve; pfam00665 101510023886 Integrase core domain; Region: rve_3; cl15866 101510023887 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 101510023888 Peptidase family M23; Region: Peptidase_M23; pfam01551 101510023889 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 101510023890 N-acetyl-D-glucosamine binding site [chemical binding]; other site 101510023891 catalytic residue [active] 101510023892 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 101510023893 NlpC/P60 family; Region: NLPC_P60; pfam00877 101510023894 AAA-like domain; Region: AAA_10; pfam12846 101510023895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 101510023896 Walker A motif; other site 101510023897 ATP binding site [chemical binding]; other site 101510023898 AAA domain; Region: AAA_31; pfam13614 101510023899 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 101510023900 Cutinase; Region: Cutinase; pfam01083 101510023901 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 101510023902 ATP-dependent helicase HepA; Validated; Region: PRK04914 101510023903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 101510023904 ATP binding site [chemical binding]; other site 101510023905 Catalytic domain of Protein Kinases; Region: PKc; cd00180 101510023906 active site 101510023907 ATP binding site [chemical binding]; other site 101510023908 substrate binding site [chemical binding]; other site 101510023909 activation loop (A-loop); other site 101510023910 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 101510023911 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 101510023912 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 101510023913 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 101510023914 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 101510023915 active site 101510023916 dimer interface [polypeptide binding]; other site 101510023917 metal binding site [ion binding]; metal-binding site 101510023918 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 101510023919 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 101510023920 active site 101510023921 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 101510023922 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 101510023923 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 101510023924 active site 101510023925 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 101510023926 Transcription factor WhiB; Region: Whib; pfam02467 101510023927 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 101510023928 Malic enzyme, N-terminal domain; Region: malic; pfam00390 101510023929 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 101510023930 putative NAD(P) binding site [chemical binding]; other site 101510023931 Helix-turn-helix domain; Region: HTH_18; pfam12833 101510023932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 101510023933 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 101510023934 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 101510023935 FMN-binding pocket [chemical binding]; other site 101510023936 flavin binding motif; other site 101510023937 phosphate binding motif [ion binding]; other site 101510023938 beta-alpha-beta structure motif; other site 101510023939 NAD binding pocket [chemical binding]; other site 101510023940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 101510023941 catalytic loop [active] 101510023942 iron binding site [ion binding]; other site 101510023943 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 101510023944 Cytochrome P450; Region: p450; cl12078 101510023945 EthD domain; Region: EthD; cl17553 101510023946 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 101510023947 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 101510023948 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 101510023949 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 101510023950 active site 101510023951 dimer interface [polypeptide binding]; other site 101510023952 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 101510023953 dimer interface [polypeptide binding]; other site 101510023954 active site 101510023955 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 101510023956 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 101510023957 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 101510023958 phosphate binding site [ion binding]; other site 101510023959 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 101510023960 tetramer interface [polypeptide binding]; other site 101510023961 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 101510023962 active site 101510023963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 101510023964 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 101510023965 ATP binding site [chemical binding]; other site 101510023966 G-X-G motif; other site 101510023967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 101510023968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 101510023969 DNA binding residues [nucleotide binding] 101510023970 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 101510023971 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 101510023972 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 101510023973 PhoU domain; Region: PhoU; pfam01895 101510023974 Clp protease ATP binding subunit; Region: clpC; CHL00095