-- dump date 20140620_024920 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698761000001 PEP synthetase regulatory protein; Provisional; Region: PRK05339 698761000002 Maf-like protein; Region: Maf; pfam02545 698761000003 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698761000004 active site 698761000005 dimer interface [polypeptide binding]; other site 698761000006 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698761000007 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698761000008 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698761000009 shikimate binding site; other site 698761000010 NAD(P) binding site [chemical binding]; other site 698761000011 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698761000012 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698761000013 CoA-binding site [chemical binding]; other site 698761000014 ATP-binding [chemical binding]; other site 698761000015 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 698761000016 active site 698761000017 catalytic site [active] 698761000018 substrate binding site [chemical binding]; other site 698761000019 preprotein translocase subunit SecB; Validated; Region: PRK05751 698761000020 SecA binding site; other site 698761000021 Preprotein binding site; other site 698761000022 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 698761000023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 698761000024 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 698761000025 MltA specific insert domain; Region: MltA; smart00925 698761000026 3D domain; Region: 3D; pfam06725 698761000027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 698761000028 Smr domain; Region: Smr; pfam01713 698761000029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761000030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761000031 non-specific DNA binding site [nucleotide binding]; other site 698761000032 salt bridge; other site 698761000033 sequence-specific DNA binding site [nucleotide binding]; other site 698761000034 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 698761000035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761000036 Mg2+ binding site [ion binding]; other site 698761000037 G-X-G motif; other site 698761000038 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698761000039 anchoring element; other site 698761000040 dimer interface [polypeptide binding]; other site 698761000041 ATP binding site [chemical binding]; other site 698761000042 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698761000043 active site 698761000044 putative metal-binding site [ion binding]; other site 698761000045 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698761000046 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 698761000047 putative FMN binding site [chemical binding]; other site 698761000048 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 698761000049 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698761000050 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698761000051 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698761000052 putative dimer interface [polypeptide binding]; other site 698761000053 N-terminal domain interface [polypeptide binding]; other site 698761000054 putative substrate binding pocket (H-site) [chemical binding]; other site 698761000055 tyrosine decarboxylase; Region: PLN02880 698761000056 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 698761000057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761000058 catalytic residue [active] 698761000059 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698761000060 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698761000061 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 698761000062 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 698761000063 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 698761000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 698761000065 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761000066 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698761000067 short chain dehydrogenase; Provisional; Region: PRK06179 698761000068 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761000069 NADP binding site [chemical binding]; other site 698761000070 active site 698761000071 steroid binding site; other site 698761000072 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698761000073 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 698761000074 putative NAD(P) binding site [chemical binding]; other site 698761000075 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698761000076 active site 698761000077 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698761000078 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698761000079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761000080 catalytic residue [active] 698761000081 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698761000082 substrate binding site [chemical binding]; other site 698761000083 active site 698761000084 catalytic residues [active] 698761000085 heterodimer interface [polypeptide binding]; other site 698761000086 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 698761000087 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698761000088 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698761000089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698761000090 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698761000091 catalytic residues [active] 698761000092 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 698761000093 Part of AAA domain; Region: AAA_19; pfam13245 698761000094 Family description; Region: UvrD_C_2; pfam13538 698761000095 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698761000096 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 698761000097 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 698761000098 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698761000099 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 698761000100 Substrate binding site; other site 698761000101 metal-binding site 698761000102 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698761000103 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 698761000104 Phosphotransferase enzyme family; Region: APH; pfam01636 698761000105 PAS fold; Region: PAS_7; pfam12860 698761000106 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698761000107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761000108 dimer interface [polypeptide binding]; other site 698761000109 phosphorylation site [posttranslational modification] 698761000110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761000111 ATP binding site [chemical binding]; other site 698761000112 Mg2+ binding site [ion binding]; other site 698761000113 G-X-G motif; other site 698761000114 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698761000115 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 698761000116 homotetramer interface [polypeptide binding]; other site 698761000117 ligand binding site [chemical binding]; other site 698761000118 catalytic site [active] 698761000119 NAD binding site [chemical binding]; other site 698761000120 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698761000121 dimerization domain swap beta strand [polypeptide binding]; other site 698761000122 regulatory protein interface [polypeptide binding]; other site 698761000123 active site 698761000124 regulatory phosphorylation site [posttranslational modification]; other site 698761000125 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 698761000126 active pocket/dimerization site; other site 698761000127 active site 698761000128 phosphorylation site [posttranslational modification] 698761000129 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 698761000130 Hpr binding site; other site 698761000131 active site 698761000132 homohexamer subunit interaction site [polypeptide binding]; other site 698761000133 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 698761000134 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 698761000135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698761000136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761000137 dimerization interface [polypeptide binding]; other site 698761000138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761000139 dimer interface [polypeptide binding]; other site 698761000140 phosphorylation site [posttranslational modification] 698761000141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761000142 ATP binding site [chemical binding]; other site 698761000143 Mg2+ binding site [ion binding]; other site 698761000144 G-X-G motif; other site 698761000145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761000146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761000147 active site 698761000148 phosphorylation site [posttranslational modification] 698761000149 intermolecular recognition site; other site 698761000150 dimerization interface [polypeptide binding]; other site 698761000151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761000152 DNA binding site [nucleotide binding] 698761000153 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 698761000154 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 698761000155 active site 698761000156 substrate-binding site [chemical binding]; other site 698761000157 metal-binding site [ion binding] 698761000158 ATP binding site [chemical binding]; other site 698761000159 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 698761000160 hypothetical protein; Provisional; Region: PRK09256 698761000161 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 698761000162 pantothenate kinase; Provisional; Region: PRK05439 698761000163 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 698761000164 ATP-binding site [chemical binding]; other site 698761000165 CoA-binding site [chemical binding]; other site 698761000166 Mg2+-binding site [ion binding]; other site 698761000167 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 698761000168 metal binding site [ion binding]; metal-binding site 698761000169 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698761000170 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698761000171 substrate binding site [chemical binding]; other site 698761000172 glutamase interaction surface [polypeptide binding]; other site 698761000173 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698761000174 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698761000175 catalytic residues [active] 698761000176 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698761000177 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698761000178 putative active site [active] 698761000179 oxyanion strand; other site 698761000180 catalytic triad [active] 698761000181 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698761000182 putative active site pocket [active] 698761000183 4-fold oligomerization interface [polypeptide binding]; other site 698761000184 metal binding residues [ion binding]; metal-binding site 698761000185 3-fold/trimer interface [polypeptide binding]; other site 698761000186 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 698761000187 active site 698761000188 HslU subunit interaction site [polypeptide binding]; other site 698761000189 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 698761000190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761000191 Walker A motif; other site 698761000192 ATP binding site [chemical binding]; other site 698761000193 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 698761000194 Walker B motif; other site 698761000195 arginine finger; other site 698761000196 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698761000197 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 698761000198 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698761000199 Cytochrome P450; Region: p450; cl12078 698761000200 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 698761000201 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 698761000202 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 698761000203 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 698761000204 active site 698761000205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698761000206 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761000207 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 698761000208 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 698761000209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761000210 active site 698761000211 phosphorylation site [posttranslational modification] 698761000212 intermolecular recognition site; other site 698761000213 dimerization interface [polypeptide binding]; other site 698761000214 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 698761000215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761000216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761000217 dimer interface [polypeptide binding]; other site 698761000218 phosphorylation site [posttranslational modification] 698761000219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761000220 ATP binding site [chemical binding]; other site 698761000221 Mg2+ binding site [ion binding]; other site 698761000222 G-X-G motif; other site 698761000223 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 698761000224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698761000225 ATP binding site [chemical binding]; other site 698761000226 putative Mg++ binding site [ion binding]; other site 698761000227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761000228 nucleotide binding region [chemical binding]; other site 698761000229 ATP-binding site [chemical binding]; other site 698761000230 Helicase associated domain (HA2); Region: HA2; pfam04408 698761000231 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698761000232 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698761000233 H+ Antiporter protein; Region: 2A0121; TIGR00900 698761000234 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761000235 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761000236 Walker A/P-loop; other site 698761000237 ATP binding site [chemical binding]; other site 698761000238 Q-loop/lid; other site 698761000239 ABC transporter signature motif; other site 698761000240 Walker B; other site 698761000241 D-loop; other site 698761000242 H-loop/switch region; other site 698761000243 TOBE domain; Region: TOBE_2; pfam08402 698761000244 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761000245 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 698761000246 substrate binding site [chemical binding]; other site 698761000247 ATP binding site [chemical binding]; other site 698761000248 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 698761000249 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 698761000250 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 698761000251 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761000252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000253 dimer interface [polypeptide binding]; other site 698761000254 conserved gate region; other site 698761000255 putative PBP binding loops; other site 698761000256 ABC-ATPase subunit interface; other site 698761000257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000258 dimer interface [polypeptide binding]; other site 698761000259 conserved gate region; other site 698761000260 putative PBP binding loops; other site 698761000261 ABC-ATPase subunit interface; other site 698761000262 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761000263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761000264 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698761000265 non-specific DNA interactions [nucleotide binding]; other site 698761000266 DNA binding site [nucleotide binding] 698761000267 sequence specific DNA binding site [nucleotide binding]; other site 698761000268 putative cAMP binding site [chemical binding]; other site 698761000269 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761000270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761000271 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 698761000272 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 698761000273 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698761000274 DNA binding site [nucleotide binding] 698761000275 active site 698761000276 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761000277 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761000278 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761000279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761000280 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761000281 active site 698761000282 catalytic tetrad [active] 698761000283 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 698761000284 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761000285 Walker A/P-loop; other site 698761000286 ATP binding site [chemical binding]; other site 698761000287 Q-loop/lid; other site 698761000288 ABC transporter signature motif; other site 698761000289 Walker B; other site 698761000290 D-loop; other site 698761000291 H-loop/switch region; other site 698761000292 TOBE domain; Region: TOBE_2; pfam08402 698761000293 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761000294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000295 dimer interface [polypeptide binding]; other site 698761000296 conserved gate region; other site 698761000297 putative PBP binding loops; other site 698761000298 ABC-ATPase subunit interface; other site 698761000299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000300 dimer interface [polypeptide binding]; other site 698761000301 conserved gate region; other site 698761000302 putative PBP binding loops; other site 698761000303 ABC-ATPase subunit interface; other site 698761000304 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761000305 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761000306 Cupin domain; Region: Cupin_2; pfam07883 698761000307 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761000308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761000309 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 698761000310 Copper resistance protein D; Region: CopD; pfam05425 698761000311 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761000312 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 698761000313 active site 698761000314 metal binding site [ion binding]; metal-binding site 698761000315 succinic semialdehyde dehydrogenase; Region: PLN02278 698761000316 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698761000317 tetramerization interface [polypeptide binding]; other site 698761000318 NAD(P) binding site [chemical binding]; other site 698761000319 catalytic residues [active] 698761000320 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 698761000321 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761000322 inhibitor-cofactor binding pocket; inhibition site 698761000323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761000324 catalytic residue [active] 698761000325 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698761000326 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698761000327 DNA binding residues [nucleotide binding] 698761000328 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 698761000329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761000330 non-specific DNA binding site [nucleotide binding]; other site 698761000331 salt bridge; other site 698761000332 sequence-specific DNA binding site [nucleotide binding]; other site 698761000333 Cupin domain; Region: Cupin_2; pfam07883 698761000334 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698761000335 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698761000336 catalytic site [active] 698761000337 putative active site [active] 698761000338 putative substrate binding site [chemical binding]; other site 698761000339 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 698761000340 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698761000341 RNA binding site [nucleotide binding]; other site 698761000342 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698761000343 RNA binding site [nucleotide binding]; other site 698761000344 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 698761000345 RNA binding site [nucleotide binding]; other site 698761000346 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698761000347 RNA binding site [nucleotide binding]; other site 698761000348 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698761000349 RNA binding site [nucleotide binding]; other site 698761000350 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 698761000351 RNA binding site [nucleotide binding]; other site 698761000352 cytidylate kinase; Provisional; Region: cmk; PRK00023 698761000353 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698761000354 CMP-binding site; other site 698761000355 The sites determining sugar specificity; other site 698761000356 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 698761000357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 698761000358 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 698761000359 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 698761000360 GIY-YIG motif/motif A; other site 698761000361 putative active site [active] 698761000362 putative metal binding site [ion binding]; other site 698761000363 Predicted membrane protein [Function unknown]; Region: COG3619 698761000364 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698761000365 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698761000366 putative active site [active] 698761000367 Predicted membrane protein [Function unknown]; Region: COG2860 698761000368 UPF0126 domain; Region: UPF0126; pfam03458 698761000369 UPF0126 domain; Region: UPF0126; pfam03458 698761000370 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698761000371 metal binding site 2 [ion binding]; metal-binding site 698761000372 putative DNA binding helix; other site 698761000373 metal binding site 1 [ion binding]; metal-binding site 698761000374 dimer interface [polypeptide binding]; other site 698761000375 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 698761000376 active site 1 [active] 698761000377 dimer interface [polypeptide binding]; other site 698761000378 active site 2 [active] 698761000379 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 698761000380 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698761000381 dimer interface [polypeptide binding]; other site 698761000382 active site 698761000383 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 698761000384 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 698761000385 NAD binding site [chemical binding]; other site 698761000386 homotetramer interface [polypeptide binding]; other site 698761000387 homodimer interface [polypeptide binding]; other site 698761000388 substrate binding site [chemical binding]; other site 698761000389 active site 698761000390 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698761000391 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761000392 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761000393 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 698761000394 Methyltransferase small domain; Region: MTS; pfam05175 698761000395 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 698761000396 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 698761000397 RNase E interface [polypeptide binding]; other site 698761000398 trimer interface [polypeptide binding]; other site 698761000399 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698761000400 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698761000401 RNase E interface [polypeptide binding]; other site 698761000402 trimer interface [polypeptide binding]; other site 698761000403 active site 698761000404 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698761000405 putative nucleic acid binding region [nucleotide binding]; other site 698761000406 G-X-X-G motif; other site 698761000407 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698761000408 RNA binding site [nucleotide binding]; other site 698761000409 domain interface; other site 698761000410 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698761000411 16S/18S rRNA binding site [nucleotide binding]; other site 698761000412 S13e-L30e interaction site [polypeptide binding]; other site 698761000413 25S rRNA binding site [nucleotide binding]; other site 698761000414 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761000415 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 698761000416 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 698761000417 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698761000418 RNA binding site [nucleotide binding]; other site 698761000419 active site 698761000420 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 698761000421 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698761000422 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 698761000423 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698761000424 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 698761000425 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698761000426 G1 box; other site 698761000427 putative GEF interaction site [polypeptide binding]; other site 698761000428 GTP/Mg2+ binding site [chemical binding]; other site 698761000429 Switch I region; other site 698761000430 G2 box; other site 698761000431 G3 box; other site 698761000432 Switch II region; other site 698761000433 G4 box; other site 698761000434 G5 box; other site 698761000435 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698761000436 Translation-initiation factor 2; Region: IF-2; pfam11987 698761000437 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698761000438 hypothetical protein; Provisional; Region: PRK09190 698761000439 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 698761000440 putative RNA binding cleft [nucleotide binding]; other site 698761000441 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 698761000442 NusA N-terminal domain; Region: NusA_N; pfam08529 698761000443 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698761000444 RNA binding site [nucleotide binding]; other site 698761000445 homodimer interface [polypeptide binding]; other site 698761000446 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698761000447 G-X-X-G motif; other site 698761000448 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698761000449 G-X-X-G motif; other site 698761000450 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 698761000451 ribosome maturation protein RimP; Reviewed; Region: PRK00092 698761000452 Sm and related proteins; Region: Sm_like; cl00259 698761000453 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 698761000454 putative oligomer interface [polypeptide binding]; other site 698761000455 putative RNA binding site [nucleotide binding]; other site 698761000456 lytic murein transglycosylase; Region: MltB_2; TIGR02283 698761000457 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698761000458 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698761000459 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761000460 recombination protein RecR; Reviewed; Region: recR; PRK00076 698761000461 RecR protein; Region: RecR; pfam02132 698761000462 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698761000463 putative active site [active] 698761000464 putative metal-binding site [ion binding]; other site 698761000465 tetramer interface [polypeptide binding]; other site 698761000466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 698761000467 MOSC domain; Region: MOSC; pfam03473 698761000468 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761000469 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 698761000470 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761000471 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 698761000472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761000473 putative DNA binding site [nucleotide binding]; other site 698761000474 putative Zn2+ binding site [ion binding]; other site 698761000475 AsnC family; Region: AsnC_trans_reg; pfam01037 698761000476 hypothetical protein; Validated; Region: PRK00153 698761000477 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 698761000478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761000479 Walker A motif; other site 698761000480 ATP binding site [chemical binding]; other site 698761000481 Walker B motif; other site 698761000482 arginine finger; other site 698761000483 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698761000484 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 698761000485 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 698761000486 nucleotide binding site/active site [active] 698761000487 HIT family signature motif; other site 698761000488 catalytic residue [active] 698761000489 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 698761000490 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 698761000491 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 698761000492 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698761000493 putative NADH binding site [chemical binding]; other site 698761000494 putative active site [active] 698761000495 nudix motif; other site 698761000496 putative metal binding site [ion binding]; other site 698761000497 HTH domain; Region: HTH_11; pfam08279 698761000498 Predicted transcriptional regulator [Transcription]; Region: COG2378 698761000499 WYL domain; Region: WYL; pfam13280 698761000500 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 698761000501 putative dimer interface [polypeptide binding]; other site 698761000502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761000503 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 698761000504 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761000505 prephenate dehydratase; Provisional; Region: PRK11899 698761000506 Prephenate dehydratase; Region: PDT; pfam00800 698761000507 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698761000508 putative L-Phe binding site [chemical binding]; other site 698761000509 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 698761000510 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 698761000511 Ligand binding site; other site 698761000512 oligomer interface; other site 698761000513 Cytochrome c2 [Energy production and conversion]; Region: COG3474 698761000514 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 698761000515 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698761000516 active site 698761000517 nucleophile elbow; other site 698761000518 Patatin phospholipase; Region: DUF3734; pfam12536 698761000519 Predicted permeases [General function prediction only]; Region: COG0679 698761000520 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 698761000521 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761000522 substrate binding site [chemical binding]; other site 698761000523 ATP binding site [chemical binding]; other site 698761000524 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698761000525 Cadmium resistance transporter; Region: Cad; pfam03596 698761000526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 698761000527 Bacterial SH3 domain; Region: SH3_4; pfam06347 698761000528 Bacterial SH3 domain; Region: SH3_4; pfam06347 698761000529 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698761000530 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 698761000531 dimerization interface [polypeptide binding]; other site 698761000532 ligand binding site [chemical binding]; other site 698761000533 NADP binding site [chemical binding]; other site 698761000534 catalytic site [active] 698761000535 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698761000536 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698761000537 hinge; other site 698761000538 active site 698761000539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761000540 Coenzyme A binding pocket [chemical binding]; other site 698761000541 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 698761000542 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698761000543 ATP binding site [chemical binding]; other site 698761000544 substrate interface [chemical binding]; other site 698761000545 recombination protein F; Reviewed; Region: recF; PRK00064 698761000546 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698761000547 Walker A/P-loop; other site 698761000548 ATP binding site [chemical binding]; other site 698761000549 Q-loop/lid; other site 698761000550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761000551 ABC transporter signature motif; other site 698761000552 Walker B; other site 698761000553 D-loop; other site 698761000554 H-loop/switch region; other site 698761000555 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 698761000556 Phosphotransferase enzyme family; Region: APH; pfam01636 698761000557 active site 698761000558 ATP binding site [chemical binding]; other site 698761000559 antibiotic binding site [chemical binding]; other site 698761000560 chaperone protein DnaJ; Provisional; Region: PRK14301 698761000561 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698761000562 HSP70 interaction site [polypeptide binding]; other site 698761000563 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 698761000564 substrate binding site [polypeptide binding]; other site 698761000565 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698761000566 Zn binding sites [ion binding]; other site 698761000567 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698761000568 dimer interface [polypeptide binding]; other site 698761000569 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698761000570 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 698761000571 nucleotide binding site [chemical binding]; other site 698761000572 NEF interaction site [polypeptide binding]; other site 698761000573 SBD interface [polypeptide binding]; other site 698761000574 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698761000575 Transglycosylase; Region: Transgly; pfam00912 698761000576 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698761000577 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761000578 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 698761000579 Bacterial SH3 domain; Region: SH3_3; pfam08239 698761000580 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 698761000581 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698761000582 ATP binding site [chemical binding]; other site 698761000583 active site 698761000584 substrate binding site [chemical binding]; other site 698761000585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761000586 active site 698761000587 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698761000588 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698761000589 RNA binding surface [nucleotide binding]; other site 698761000590 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698761000591 active site 698761000592 osmolarity response regulator; Provisional; Region: ompR; PRK09468 698761000593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761000594 active site 698761000595 phosphorylation site [posttranslational modification] 698761000596 intermolecular recognition site; other site 698761000597 dimerization interface [polypeptide binding]; other site 698761000598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761000599 DNA binding site [nucleotide binding] 698761000600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761000601 dimerization interface [polypeptide binding]; other site 698761000602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761000603 dimer interface [polypeptide binding]; other site 698761000604 phosphorylation site [posttranslational modification] 698761000605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761000606 ATP binding site [chemical binding]; other site 698761000607 Mg2+ binding site [ion binding]; other site 698761000608 G-X-G motif; other site 698761000609 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761000610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761000611 Walker A/P-loop; other site 698761000612 ATP binding site [chemical binding]; other site 698761000613 Q-loop/lid; other site 698761000614 ABC transporter signature motif; other site 698761000615 Walker B; other site 698761000616 D-loop; other site 698761000617 H-loop/switch region; other site 698761000618 TOBE domain; Region: TOBE_2; pfam08402 698761000619 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000621 dimer interface [polypeptide binding]; other site 698761000622 conserved gate region; other site 698761000623 putative PBP binding loops; other site 698761000624 ABC-ATPase subunit interface; other site 698761000625 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761000626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000627 dimer interface [polypeptide binding]; other site 698761000628 conserved gate region; other site 698761000629 putative PBP binding loops; other site 698761000630 ABC-ATPase subunit interface; other site 698761000631 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698761000632 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761000633 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 698761000634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761000635 active site 698761000636 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 698761000637 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698761000638 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698761000639 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761000640 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698761000641 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 698761000642 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698761000643 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698761000644 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 698761000645 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 698761000646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698761000647 catalytic core [active] 698761000648 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698761000649 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 698761000650 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 698761000651 Subunit I/III interface [polypeptide binding]; other site 698761000652 Subunit III/IV interface [polypeptide binding]; other site 698761000653 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698761000654 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698761000655 D-pathway; other site 698761000656 Putative ubiquinol binding site [chemical binding]; other site 698761000657 Low-spin heme (heme b) binding site [chemical binding]; other site 698761000658 Putative water exit pathway; other site 698761000659 Binuclear center (heme o3/CuB) [ion binding]; other site 698761000660 K-pathway; other site 698761000661 Putative proton exit pathway; other site 698761000662 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 698761000663 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698761000664 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 698761000665 metabolite-proton symporter; Region: 2A0106; TIGR00883 698761000666 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698761000667 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698761000668 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698761000669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000670 dimer interface [polypeptide binding]; other site 698761000671 conserved gate region; other site 698761000672 putative PBP binding loops; other site 698761000673 ABC-ATPase subunit interface; other site 698761000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000675 dimer interface [polypeptide binding]; other site 698761000676 conserved gate region; other site 698761000677 putative PBP binding loops; other site 698761000678 ABC-ATPase subunit interface; other site 698761000679 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761000680 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698761000681 Walker A/P-loop; other site 698761000682 ATP binding site [chemical binding]; other site 698761000683 Q-loop/lid; other site 698761000684 ABC transporter signature motif; other site 698761000685 Walker B; other site 698761000686 D-loop; other site 698761000687 H-loop/switch region; other site 698761000688 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698761000689 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 698761000690 metal binding site [ion binding]; metal-binding site 698761000691 putative dimer interface [polypeptide binding]; other site 698761000692 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 698761000693 active site 698761000694 hypothetical protein; Validated; Region: PRK09104 698761000695 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 698761000696 metal binding site [ion binding]; metal-binding site 698761000697 putative dimer interface [polypeptide binding]; other site 698761000698 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 698761000699 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 698761000700 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 698761000701 PAS domain S-box; Region: sensory_box; TIGR00229 698761000702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761000703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761000704 metal binding site [ion binding]; metal-binding site 698761000705 active site 698761000706 I-site; other site 698761000707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761000708 MarR family; Region: MarR; pfam01047 698761000709 DNA polymerase I; Region: pola; TIGR00593 698761000710 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698761000711 active site 698761000712 metal binding site 1 [ion binding]; metal-binding site 698761000713 putative 5' ssDNA interaction site; other site 698761000714 metal binding site 3; metal-binding site 698761000715 metal binding site 2 [ion binding]; metal-binding site 698761000716 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698761000717 putative DNA binding site [nucleotide binding]; other site 698761000718 putative metal binding site [ion binding]; other site 698761000719 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 698761000720 active site 698761000721 catalytic site [active] 698761000722 substrate binding site [chemical binding]; other site 698761000723 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698761000724 active site 698761000725 DNA binding site [nucleotide binding] 698761000726 catalytic site [active] 698761000727 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 698761000728 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698761000729 active site 698761000730 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 698761000731 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761000732 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 698761000733 active site 698761000734 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 698761000735 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 698761000736 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 698761000737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000738 dimer interface [polypeptide binding]; other site 698761000739 conserved gate region; other site 698761000740 ABC-ATPase subunit interface; other site 698761000741 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 698761000742 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 698761000743 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 698761000744 Walker A/P-loop; other site 698761000745 ATP binding site [chemical binding]; other site 698761000746 Q-loop/lid; other site 698761000747 ABC transporter signature motif; other site 698761000748 Walker B; other site 698761000749 D-loop; other site 698761000750 H-loop/switch region; other site 698761000751 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 698761000752 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 698761000753 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 698761000754 trimer interface [polypeptide binding]; other site 698761000755 active site 698761000756 substrate binding site [chemical binding]; other site 698761000757 CoA binding site [chemical binding]; other site 698761000758 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 698761000759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761000760 Walker A/P-loop; other site 698761000761 ATP binding site [chemical binding]; other site 698761000762 Q-loop/lid; other site 698761000763 ABC transporter signature motif; other site 698761000764 Walker B; other site 698761000765 D-loop; other site 698761000766 H-loop/switch region; other site 698761000767 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 698761000768 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761000769 Walker A/P-loop; other site 698761000770 ATP binding site [chemical binding]; other site 698761000771 Q-loop/lid; other site 698761000772 ABC transporter signature motif; other site 698761000773 Walker B; other site 698761000774 D-loop; other site 698761000775 H-loop/switch region; other site 698761000776 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761000777 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 698761000778 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 698761000779 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 698761000780 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 698761000781 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 698761000782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761000783 DNA-binding site [nucleotide binding]; DNA binding site 698761000784 UTRA domain; Region: UTRA; pfam07702 698761000785 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698761000786 catalytic core [active] 698761000787 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 698761000788 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698761000789 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698761000790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761000791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761000792 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 698761000793 Walker A/P-loop; other site 698761000794 ATP binding site [chemical binding]; other site 698761000795 Q-loop/lid; other site 698761000796 ABC transporter signature motif; other site 698761000797 Walker B; other site 698761000798 D-loop; other site 698761000799 H-loop/switch region; other site 698761000800 glucokinase; Provisional; Region: glk; PRK00292 698761000801 glucokinase, proteobacterial type; Region: glk; TIGR00749 698761000802 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 698761000803 active site 698761000804 dimer interfaces [polypeptide binding]; other site 698761000805 catalytic residues [active] 698761000806 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 698761000807 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 698761000808 Isochorismatase family; Region: Isochorismatase; pfam00857 698761000809 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698761000810 catalytic triad [active] 698761000811 conserved cis-peptide bond; other site 698761000812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761000813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761000814 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698761000815 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 698761000816 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 698761000817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000818 dimer interface [polypeptide binding]; other site 698761000819 conserved gate region; other site 698761000820 putative PBP binding loops; other site 698761000821 ABC-ATPase subunit interface; other site 698761000822 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 698761000823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761000824 dimer interface [polypeptide binding]; other site 698761000825 conserved gate region; other site 698761000826 putative PBP binding loops; other site 698761000827 ABC-ATPase subunit interface; other site 698761000828 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698761000829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761000830 Walker A/P-loop; other site 698761000831 ATP binding site [chemical binding]; other site 698761000832 Q-loop/lid; other site 698761000833 ABC transporter signature motif; other site 698761000834 Walker B; other site 698761000835 D-loop; other site 698761000836 H-loop/switch region; other site 698761000837 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698761000838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761000839 Walker A/P-loop; other site 698761000840 ATP binding site [chemical binding]; other site 698761000841 Q-loop/lid; other site 698761000842 ABC transporter signature motif; other site 698761000843 Walker B; other site 698761000844 D-loop; other site 698761000845 H-loop/switch region; other site 698761000846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761000847 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698761000848 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 698761000849 putative ligand binding site [chemical binding]; other site 698761000850 NAD binding site [chemical binding]; other site 698761000851 dimerization interface [polypeptide binding]; other site 698761000852 catalytic site [active] 698761000853 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 698761000854 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 698761000855 active site 698761000856 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698761000857 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698761000858 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761000859 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761000860 DNA binding site [nucleotide binding] 698761000861 domain linker motif; other site 698761000862 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698761000863 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698761000864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761000865 NAD(P) binding site [chemical binding]; other site 698761000866 active site 698761000867 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698761000868 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698761000869 FMN binding site [chemical binding]; other site 698761000870 active site 698761000871 substrate binding site [chemical binding]; other site 698761000872 catalytic residue [active] 698761000873 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761000874 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761000875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761000876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761000877 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 698761000878 putative dimerization interface [polypeptide binding]; other site 698761000879 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698761000880 Isochorismatase family; Region: Isochorismatase; pfam00857 698761000881 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 698761000882 catalytic triad [active] 698761000883 conserved cis-peptide bond; other site 698761000884 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761000885 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698761000886 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761000887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761000888 putative substrate translocation pore; other site 698761000889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761000890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761000891 salt bridge; other site 698761000892 non-specific DNA binding site [nucleotide binding]; other site 698761000893 sequence-specific DNA binding site [nucleotide binding]; other site 698761000894 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 698761000895 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761000896 putative NAD(P) binding site [chemical binding]; other site 698761000897 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 698761000898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761000899 hypothetical protein; Provisional; Region: PRK06834 698761000900 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761000901 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761000902 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698761000903 RibD C-terminal domain; Region: RibD_C; cl17279 698761000904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761000905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761000906 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 698761000907 ligand binding site [chemical binding]; other site 698761000908 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761000909 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698761000910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761000911 Walker A/P-loop; other site 698761000912 ATP binding site [chemical binding]; other site 698761000913 Q-loop/lid; other site 698761000914 ABC transporter signature motif; other site 698761000915 Walker B; other site 698761000916 D-loop; other site 698761000917 H-loop/switch region; other site 698761000918 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761000919 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761000920 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761000921 TM-ABC transporter signature motif; other site 698761000922 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761000923 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761000924 TM-ABC transporter signature motif; other site 698761000925 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698761000926 active site 698761000927 catalytic motif [active] 698761000928 Zn binding site [ion binding]; other site 698761000929 purine nucleoside phosphorylase; Provisional; Region: PRK08202 698761000930 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698761000931 intersubunit interface [polypeptide binding]; other site 698761000932 active site 698761000933 catalytic residue [active] 698761000934 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 698761000935 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698761000936 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698761000937 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 698761000938 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 698761000939 catalytic motif [active] 698761000940 Catalytic residue [active] 698761000941 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761000942 active site 698761000943 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 698761000944 adenosine deaminase; Provisional; Region: PRK09358 698761000945 active site 698761000946 phosphopentomutase; Provisional; Region: PRK05362 698761000947 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 698761000948 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698761000949 TadE-like protein; Region: TadE; pfam07811 698761000950 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698761000951 TadE-like protein; Region: TadE; pfam07811 698761000952 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 698761000953 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 698761000954 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 698761000955 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 698761000956 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 698761000957 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 698761000958 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 698761000959 BON domain; Region: BON; pfam04972 698761000960 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 698761000961 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 698761000962 Type IV pili component [Cell motility and secretion]; Region: COG5461 698761000963 AAA domain; Region: AAA_31; pfam13614 698761000964 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 698761000965 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 698761000966 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 698761000967 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698761000968 ATP binding site [chemical binding]; other site 698761000969 Walker A motif; other site 698761000970 hexamer interface [polypeptide binding]; other site 698761000971 Walker B motif; other site 698761000972 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698761000973 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698761000974 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 698761000975 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698761000976 LysE type translocator; Region: LysE; cl00565 698761000977 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 698761000978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761000979 TPR motif; other site 698761000980 binding surface 698761000981 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 698761000982 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698761000983 interface (dimer of trimers) [polypeptide binding]; other site 698761000984 Substrate-binding/catalytic site; other site 698761000985 Zn-binding sites [ion binding]; other site 698761000986 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761000987 MarR family; Region: MarR_2; cl17246 698761000988 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 698761000989 NlpC/P60 family; Region: NLPC_P60; cl17555 698761000990 EamA-like transporter family; Region: EamA; pfam00892 698761000991 EamA-like transporter family; Region: EamA; pfam00892 698761000992 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761000993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761000994 putative DNA binding site [nucleotide binding]; other site 698761000995 putative Zn2+ binding site [ion binding]; other site 698761000996 AsnC family; Region: AsnC_trans_reg; pfam01037 698761000997 amidase; Provisional; Region: PRK07042 698761000998 Amidase; Region: Amidase; pfam01425 698761000999 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761001000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761001001 dimer interface [polypeptide binding]; other site 698761001002 conserved gate region; other site 698761001003 putative PBP binding loops; other site 698761001004 ABC-ATPase subunit interface; other site 698761001005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761001006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761001007 dimer interface [polypeptide binding]; other site 698761001008 ABC-ATPase subunit interface; other site 698761001009 putative PBP binding loops; other site 698761001010 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761001011 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698761001012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761001013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761001015 dimerization interface [polypeptide binding]; other site 698761001016 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698761001017 putative active site pocket [active] 698761001018 cleavage site 698761001019 hypothetical protein; Provisional; Region: PRK06149 698761001020 active site 698761001021 ATP binding site [chemical binding]; other site 698761001022 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698761001023 substrate binding site [chemical binding]; other site 698761001024 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761001025 inhibitor-cofactor binding pocket; inhibition site 698761001026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761001027 catalytic residue [active] 698761001028 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 698761001029 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 698761001030 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 698761001031 putative active site [active] 698761001032 putative substrate binding site [chemical binding]; other site 698761001033 putative cosubstrate binding site; other site 698761001034 catalytic site [active] 698761001035 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 698761001036 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 698761001037 Chain length determinant protein; Region: Wzz; pfam02706 698761001038 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 698761001039 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 698761001040 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698761001041 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 698761001042 NAD(P) binding site [chemical binding]; other site 698761001043 homodimer interface [polypeptide binding]; other site 698761001044 substrate binding site [chemical binding]; other site 698761001045 active site 698761001046 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 698761001047 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761001048 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761001049 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761001050 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 698761001051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761001052 dimer interface [polypeptide binding]; other site 698761001053 conserved gate region; other site 698761001054 putative PBP binding loops; other site 698761001055 ABC-ATPase subunit interface; other site 698761001056 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761001057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761001058 dimer interface [polypeptide binding]; other site 698761001059 conserved gate region; other site 698761001060 ABC-ATPase subunit interface; other site 698761001061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761001062 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761001063 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761001064 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761001065 Walker A/P-loop; other site 698761001066 ATP binding site [chemical binding]; other site 698761001067 Q-loop/lid; other site 698761001068 ABC transporter signature motif; other site 698761001069 Walker B; other site 698761001070 D-loop; other site 698761001071 H-loop/switch region; other site 698761001072 TOBE domain; Region: TOBE_2; pfam08402 698761001073 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 698761001074 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 698761001075 dimer interface [polypeptide binding]; other site 698761001076 active site 698761001077 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698761001078 substrate binding site [chemical binding]; other site 698761001079 catalytic residue [active] 698761001080 Uncharacterized conserved protein [Function unknown]; Region: COG5476 698761001081 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 698761001082 MlrC C-terminus; Region: MlrC_C; pfam07171 698761001083 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698761001084 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698761001085 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698761001086 putative active site [active] 698761001087 short chain dehydrogenase; Provisional; Region: PRK07074 698761001088 classical (c) SDRs; Region: SDR_c; cd05233 698761001089 NAD(P) binding site [chemical binding]; other site 698761001090 active site 698761001091 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 698761001092 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 698761001093 active site 698761001094 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761001095 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 698761001096 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 698761001097 active site 698761001098 substrate binding site [chemical binding]; other site 698761001099 metal binding site [ion binding]; metal-binding site 698761001100 BA14K-like protein; Region: BA14K; pfam07886 698761001101 Rdx family; Region: Rdx; cl01407 698761001102 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698761001103 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698761001104 catalytic triad [active] 698761001105 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761001106 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 698761001107 GTP-binding protein LepA; Provisional; Region: PRK05433 698761001108 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698761001109 G1 box; other site 698761001110 putative GEF interaction site [polypeptide binding]; other site 698761001111 GTP/Mg2+ binding site [chemical binding]; other site 698761001112 Switch I region; other site 698761001113 G2 box; other site 698761001114 G3 box; other site 698761001115 Switch II region; other site 698761001116 G4 box; other site 698761001117 G5 box; other site 698761001118 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698761001119 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698761001120 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698761001121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761001122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761001123 non-specific DNA binding site [nucleotide binding]; other site 698761001124 salt bridge; other site 698761001125 sequence-specific DNA binding site [nucleotide binding]; other site 698761001126 Cupin domain; Region: Cupin_2; cl17218 698761001127 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 698761001128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761001129 motif II; other site 698761001130 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 698761001131 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 698761001132 active site 698761001133 Zn binding site [ion binding]; other site 698761001134 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698761001135 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698761001136 apolar tunnel; other site 698761001137 heme binding site [chemical binding]; other site 698761001138 dimerization interface [polypeptide binding]; other site 698761001139 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 698761001140 diiron binding motif [ion binding]; other site 698761001141 Uncharacterized conserved protein [Function unknown]; Region: COG1633 698761001142 CCC1-related protein family; Region: CCC1_like_1; cd02437 698761001143 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 698761001144 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761001145 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698761001146 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698761001147 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698761001148 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698761001149 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698761001150 23S rRNA binding site [nucleotide binding]; other site 698761001151 L21 binding site [polypeptide binding]; other site 698761001152 L13 binding site [polypeptide binding]; other site 698761001153 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698761001154 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698761001155 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698761001156 dimer interface [polypeptide binding]; other site 698761001157 motif 1; other site 698761001158 active site 698761001159 motif 2; other site 698761001160 motif 3; other site 698761001161 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698761001162 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698761001163 putative tRNA-binding site [nucleotide binding]; other site 698761001164 B3/4 domain; Region: B3_4; pfam03483 698761001165 tRNA synthetase B5 domain; Region: B5; smart00874 698761001166 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698761001167 dimer interface [polypeptide binding]; other site 698761001168 motif 1; other site 698761001169 motif 3; other site 698761001170 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 698761001171 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 698761001172 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 698761001173 Transglycosylase; Region: Transgly; pfam00912 698761001174 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698761001175 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 698761001176 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 698761001177 putative binding site; other site 698761001178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761001179 binding surface 698761001180 TPR motif; other site 698761001181 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 698761001182 MG2 domain; Region: A2M_N; pfam01835 698761001183 Alpha-2-macroglobulin family; Region: A2M; pfam00207 698761001184 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 698761001185 surface patch; other site 698761001186 thioester region; other site 698761001187 specificity defining residues; other site 698761001188 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761001189 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761001190 active site 698761001191 catalytic tetrad [active] 698761001192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761001193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001194 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698761001195 putative effector binding pocket; other site 698761001196 putative dimerization interface [polypeptide binding]; other site 698761001197 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698761001198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761001199 Coenzyme A binding pocket [chemical binding]; other site 698761001200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761001201 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761001202 active site 698761001203 catalytic tetrad [active] 698761001204 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761001205 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761001206 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761001207 GtrA-like protein; Region: GtrA; pfam04138 698761001208 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 698761001209 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 698761001210 Ligand binding site; other site 698761001211 Putative Catalytic site; other site 698761001212 DXD motif; other site 698761001213 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698761001214 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698761001215 generic binding surface II; other site 698761001216 generic binding surface I; other site 698761001217 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 698761001218 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761001219 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 698761001220 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 698761001221 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698761001222 putative deacylase active site [active] 698761001223 HicB family; Region: HicB; pfam05534 698761001224 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 698761001225 ArsC family; Region: ArsC; pfam03960 698761001226 putative catalytic residues [active] 698761001227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761001228 MarR family; Region: MarR_2; pfam12802 698761001229 MarR family; Region: MarR_2; cl17246 698761001230 Predicted deacylase [General function prediction only]; Region: COG3608 698761001231 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 698761001232 active site 698761001233 Zn binding site [ion binding]; other site 698761001234 major facilitator superfamily transporter; Provisional; Region: PRK05122 698761001235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761001236 putative substrate translocation pore; other site 698761001237 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 698761001238 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698761001239 NADP binding site [chemical binding]; other site 698761001240 dimer interface [polypeptide binding]; other site 698761001241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761001242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001243 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698761001244 dimerization interface [polypeptide binding]; other site 698761001245 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 698761001246 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 698761001247 Sulfate transporter family; Region: Sulfate_transp; pfam00916 698761001248 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 698761001249 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 698761001250 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 698761001251 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698761001252 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698761001253 DNA binding site [nucleotide binding] 698761001254 active site 698761001255 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698761001256 active site 698761001257 SUMO-1 interface [polypeptide binding]; other site 698761001258 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761001259 hypothetical protein; Provisional; Region: PRK06834 698761001260 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 698761001261 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 698761001262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761001263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761001264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761001265 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 698761001266 GMP synthase; Reviewed; Region: guaA; PRK00074 698761001267 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698761001268 AMP/PPi binding site [chemical binding]; other site 698761001269 candidate oxyanion hole; other site 698761001270 catalytic triad [active] 698761001271 potential glutamine specificity residues [chemical binding]; other site 698761001272 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698761001273 ATP Binding subdomain [chemical binding]; other site 698761001274 Ligand Binding sites [chemical binding]; other site 698761001275 Dimerization subdomain; other site 698761001276 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 698761001277 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 698761001278 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698761001279 CoenzymeA binding site [chemical binding]; other site 698761001280 subunit interaction site [polypeptide binding]; other site 698761001281 PHB binding site; other site 698761001282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761001283 Serine hydrolase; Region: Ser_hydrolase; cl17834 698761001284 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761001285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761001286 DNA-binding site [nucleotide binding]; DNA binding site 698761001287 FCD domain; Region: FCD; pfam07729 698761001288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 698761001289 Imelysin; Region: Peptidase_M75; cl09159 698761001290 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 698761001291 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 698761001292 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 698761001293 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 698761001294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761001295 S-adenosylmethionine binding site [chemical binding]; other site 698761001296 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 698761001297 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 698761001298 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761001299 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 698761001300 putative NAD(P) binding site [chemical binding]; other site 698761001301 Domain of unknown function (DUF1731); Region: DUF1731; pfam08338 698761001302 epoxyqueuosine reductase; Region: TIGR00276 698761001303 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 698761001304 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761001305 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 698761001306 C-terminal domain interface [polypeptide binding]; other site 698761001307 GSH binding site (G-site) [chemical binding]; other site 698761001308 dimer interface [polypeptide binding]; other site 698761001309 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 698761001310 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698761001311 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 698761001312 putative NAD(P) binding site [chemical binding]; other site 698761001313 active site 698761001314 Uncharacterized conserved protein [Function unknown]; Region: COG5470 698761001315 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698761001316 active site 698761001317 dimer interface [polypeptide binding]; other site 698761001318 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 698761001319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761001320 S-adenosylmethionine binding site [chemical binding]; other site 698761001321 DNA polymerase III subunit beta; Validated; Region: PRK05643 698761001322 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698761001323 putative DNA binding surface [nucleotide binding]; other site 698761001324 dimer interface [polypeptide binding]; other site 698761001325 beta-clamp/clamp loader binding surface; other site 698761001326 beta-clamp/translesion DNA polymerase binding surface; other site 698761001327 Predicted methyltransferases [General function prediction only]; Region: COG0313 698761001328 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698761001329 putative SAM binding site [chemical binding]; other site 698761001330 putative homodimer interface [polypeptide binding]; other site 698761001331 hypothetical protein; Reviewed; Region: PRK12497 698761001332 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698761001333 putative catalytic site [active] 698761001334 putative phosphate binding site [ion binding]; other site 698761001335 putative metal binding site [ion binding]; other site 698761001336 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 698761001337 glutathione synthetase; Provisional; Region: PRK05246 698761001338 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 698761001339 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 698761001340 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698761001341 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698761001342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761001343 Walker A motif; other site 698761001344 ATP binding site [chemical binding]; other site 698761001345 Walker B motif; other site 698761001346 arginine finger; other site 698761001347 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698761001348 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698761001349 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698761001350 dimer interface [polypeptide binding]; other site 698761001351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761001352 catalytic residue [active] 698761001353 Isochorismatase family; Region: Isochorismatase; pfam00857 698761001354 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 698761001355 catalytic triad [active] 698761001356 conserved cis-peptide bond; other site 698761001357 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761001358 NIPSNAP; Region: NIPSNAP; pfam07978 698761001359 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761001360 EamA-like transporter family; Region: EamA; pfam00892 698761001361 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761001362 AsnC family; Region: AsnC_trans_reg; pfam01037 698761001363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 698761001364 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698761001365 trimer interface [polypeptide binding]; other site 698761001366 active site 698761001367 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698761001368 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698761001369 G1 box; other site 698761001370 putative GEF interaction site [polypeptide binding]; other site 698761001371 GTP/Mg2+ binding site [chemical binding]; other site 698761001372 Switch I region; other site 698761001373 G2 box; other site 698761001374 G3 box; other site 698761001375 Switch II region; other site 698761001376 G4 box; other site 698761001377 G5 box; other site 698761001378 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 698761001379 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761001380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761001381 non-specific DNA binding site [nucleotide binding]; other site 698761001382 salt bridge; other site 698761001383 sequence-specific DNA binding site [nucleotide binding]; other site 698761001384 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 698761001385 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 698761001386 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698761001387 putative metal binding site [ion binding]; other site 698761001388 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 698761001389 homodimer interaction site [polypeptide binding]; other site 698761001390 cofactor binding site; other site 698761001391 Sulfatase; Region: Sulfatase; cl17466 698761001392 choline-sulfatase; Region: chol_sulfatase; TIGR03417 698761001393 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 698761001394 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 698761001395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761001397 dimerization interface [polypeptide binding]; other site 698761001398 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 698761001399 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698761001400 active site 698761001401 homotetramer interface [polypeptide binding]; other site 698761001402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761001403 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 698761001404 active site 698761001405 motif I; other site 698761001406 motif II; other site 698761001407 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 698761001408 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 698761001409 putative active site [active] 698761001410 putative dimer interface [polypeptide binding]; other site 698761001411 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698761001412 Flavoprotein; Region: Flavoprotein; pfam02441 698761001413 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698761001414 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 698761001415 short chain dehydrogenase; Provisional; Region: PRK07478 698761001416 classical (c) SDRs; Region: SDR_c; cd05233 698761001417 NAD(P) binding site [chemical binding]; other site 698761001418 active site 698761001419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761001420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001421 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761001422 putative effector binding pocket; other site 698761001423 dimerization interface [polypeptide binding]; other site 698761001424 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 698761001425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001426 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 698761001427 putative dimerization interface [polypeptide binding]; other site 698761001428 putative substrate binding pocket [chemical binding]; other site 698761001429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761001430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761001431 putative substrate translocation pore; other site 698761001432 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 698761001433 dimer interface [polypeptide binding]; other site 698761001434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761001435 metal binding site [ion binding]; metal-binding site 698761001436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761001437 dimerization interface [polypeptide binding]; other site 698761001438 putative DNA binding site [nucleotide binding]; other site 698761001439 putative Zn2+ binding site [ion binding]; other site 698761001440 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698761001441 hydrophobic ligand binding site; other site 698761001442 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761001443 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698761001444 oligomeric interface; other site 698761001445 putative active site [active] 698761001446 homodimer interface [polypeptide binding]; other site 698761001447 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 698761001448 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 698761001449 urocanate hydratase; Provisional; Region: PRK05414 698761001450 Protein of unknown function (DUF917); Region: DUF917; pfam06032 698761001451 allantoate amidohydrolase; Reviewed; Region: PRK12893 698761001452 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 698761001453 active site 698761001454 metal binding site [ion binding]; metal-binding site 698761001455 dimer interface [polypeptide binding]; other site 698761001456 allantoinase; Region: allantoinase; TIGR03178 698761001457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761001458 active site 698761001459 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 698761001460 active sites [active] 698761001461 tetramer interface [polypeptide binding]; other site 698761001462 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 698761001463 ABC1 family; Region: ABC1; pfam03109 698761001464 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 698761001465 active site 698761001466 ATP binding site [chemical binding]; other site 698761001467 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698761001468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761001469 S-adenosylmethionine binding site [chemical binding]; other site 698761001470 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698761001471 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698761001472 DNA binding site [nucleotide binding] 698761001473 catalytic residue [active] 698761001474 H2TH interface [polypeptide binding]; other site 698761001475 putative catalytic residues [active] 698761001476 turnover-facilitating residue; other site 698761001477 intercalation triad [nucleotide binding]; other site 698761001478 8OG recognition residue [nucleotide binding]; other site 698761001479 putative reading head residues; other site 698761001480 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698761001481 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698761001482 enoyl-CoA hydratase; Provisional; Region: PRK05862 698761001483 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761001484 substrate binding site [chemical binding]; other site 698761001485 oxyanion hole (OAH) forming residues; other site 698761001486 trimer interface [polypeptide binding]; other site 698761001487 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698761001488 DnaA N-terminal domain; Region: DnaA_N; pfam11638 698761001489 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 698761001490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761001491 Walker A motif; other site 698761001492 ATP binding site [chemical binding]; other site 698761001493 Walker B motif; other site 698761001494 arginine finger; other site 698761001495 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698761001496 DnaA box-binding interface [nucleotide binding]; other site 698761001497 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761001498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001499 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698761001500 dimerization interface [polypeptide binding]; other site 698761001501 substrate binding pocket [chemical binding]; other site 698761001502 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 698761001503 EamA-like transporter family; Region: EamA; pfam00892 698761001504 EamA-like transporter family; Region: EamA; pfam00892 698761001505 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 698761001506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761001507 FeS/SAM binding site; other site 698761001508 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698761001509 active site 698761001510 dimerization interface [polypeptide binding]; other site 698761001511 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 698761001512 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761001513 ribonuclease PH; Reviewed; Region: rph; PRK00173 698761001514 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698761001515 hexamer interface [polypeptide binding]; other site 698761001516 active site 698761001517 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698761001518 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761001519 heat shock protein GrpE; Provisional; Region: PRK14141 698761001520 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698761001521 dimer interface [polypeptide binding]; other site 698761001522 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698761001523 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698761001524 active site 698761001525 phosphorylation site [posttranslational modification] 698761001526 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698761001527 30S subunit binding site; other site 698761001528 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 698761001529 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 698761001530 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 698761001531 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 698761001532 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 698761001533 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 698761001534 Walker A/P-loop; other site 698761001535 ATP binding site [chemical binding]; other site 698761001536 Q-loop/lid; other site 698761001537 ABC transporter signature motif; other site 698761001538 Walker B; other site 698761001539 D-loop; other site 698761001540 H-loop/switch region; other site 698761001541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 698761001542 OstA-like protein; Region: OstA; pfam03968 698761001543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 698761001544 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 698761001545 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 698761001546 tandem repeat interface [polypeptide binding]; other site 698761001547 oligomer interface [polypeptide binding]; other site 698761001548 active site residues [active] 698761001549 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698761001550 IHF dimer interface [polypeptide binding]; other site 698761001551 IHF - DNA interface [nucleotide binding]; other site 698761001552 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 698761001553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761001554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761001555 Coenzyme A binding pocket [chemical binding]; other site 698761001556 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 698761001557 putative hydrophobic ligand binding site [chemical binding]; other site 698761001558 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 698761001559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761001560 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698761001561 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698761001562 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698761001563 lipoprotein signal peptidase; Provisional; Region: PRK14795 698761001564 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698761001565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761001566 dimer interface [polypeptide binding]; other site 698761001567 phosphorylation site [posttranslational modification] 698761001568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761001569 ATP binding site [chemical binding]; other site 698761001570 Mg2+ binding site [ion binding]; other site 698761001571 G-X-G motif; other site 698761001572 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698761001573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761001574 active site 698761001575 phosphorylation site [posttranslational modification] 698761001576 intermolecular recognition site; other site 698761001577 dimerization interface [polypeptide binding]; other site 698761001578 Putative hemolysin [General function prediction only]; Region: COG3176 698761001579 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761001580 cyclase homology domain; Region: CHD; cd07302 698761001581 nucleotidyl binding site; other site 698761001582 metal binding site [ion binding]; metal-binding site 698761001583 dimer interface [polypeptide binding]; other site 698761001584 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 698761001585 Malic enzyme, N-terminal domain; Region: malic; pfam00390 698761001586 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 698761001587 putative NAD(P) binding site [chemical binding]; other site 698761001588 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 698761001589 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 698761001590 MutS domain I; Region: MutS_I; pfam01624 698761001591 MutS domain II; Region: MutS_II; pfam05188 698761001592 MutS domain III; Region: MutS_III; pfam05192 698761001593 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 698761001594 Walker A/P-loop; other site 698761001595 ATP binding site [chemical binding]; other site 698761001596 Q-loop/lid; other site 698761001597 ABC transporter signature motif; other site 698761001598 Walker B; other site 698761001599 D-loop; other site 698761001600 H-loop/switch region; other site 698761001601 PII uridylyl-transferase; Provisional; Region: PRK05092 698761001602 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698761001603 metal binding triad; other site 698761001604 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698761001605 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698761001606 Zn2+ binding site [ion binding]; other site 698761001607 Mg2+ binding site [ion binding]; other site 698761001608 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 698761001609 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 698761001610 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698761001611 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 698761001612 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 698761001613 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761001614 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698761001615 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698761001616 active site 698761001617 HIGH motif; other site 698761001618 dimer interface [polypeptide binding]; other site 698761001619 KMSKS motif; other site 698761001620 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698761001621 Ligand Binding Site [chemical binding]; other site 698761001622 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 698761001623 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 698761001624 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698761001625 Glycoprotease family; Region: Peptidase_M22; pfam00814 698761001626 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698761001627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761001628 Coenzyme A binding pocket [chemical binding]; other site 698761001629 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698761001630 metal binding site 2 [ion binding]; metal-binding site 698761001631 putative DNA binding helix; other site 698761001632 metal binding site 1 [ion binding]; metal-binding site 698761001633 dimer interface [polypeptide binding]; other site 698761001634 structural Zn2+ binding site [ion binding]; other site 698761001635 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698761001636 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698761001637 putative acyl-acceptor binding pocket; other site 698761001638 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 698761001639 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698761001640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761001641 FeS/SAM binding site; other site 698761001642 TRAM domain; Region: TRAM; pfam01938 698761001643 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698761001644 PhoH-like protein; Region: PhoH; pfam02562 698761001645 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 698761001646 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698761001647 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698761001648 Transporter associated domain; Region: CorC_HlyC; smart01091 698761001649 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 698761001650 Protein of unknown function (DUF989); Region: DUF989; pfam06181 698761001651 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698761001652 putative active site [active] 698761001653 catalytic triad [active] 698761001654 putative dimer interface [polypeptide binding]; other site 698761001655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761001656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761001657 non-specific DNA binding site [nucleotide binding]; other site 698761001658 salt bridge; other site 698761001659 sequence-specific DNA binding site [nucleotide binding]; other site 698761001660 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698761001661 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698761001662 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698761001663 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698761001664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761001665 S-adenosylmethionine binding site [chemical binding]; other site 698761001666 Uncharacterized small protein [Function unknown]; Region: COG5568 698761001667 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698761001668 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 698761001669 putative dimer interface [polypeptide binding]; other site 698761001670 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698761001671 active site 698761001672 tetramer interface [polypeptide binding]; other site 698761001673 Cache domain; Region: Cache_1; pfam02743 698761001674 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 698761001675 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761001676 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761001677 dimer interface [polypeptide binding]; other site 698761001678 putative CheW interface [polypeptide binding]; other site 698761001679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761001680 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698761001681 substrate binding site [chemical binding]; other site 698761001682 dimer interface [polypeptide binding]; other site 698761001683 ATP binding site [chemical binding]; other site 698761001684 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 698761001685 RmuC family; Region: RmuC; pfam02646 698761001686 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698761001687 active site 698761001688 catalytic residues [active] 698761001689 metal binding site [ion binding]; metal-binding site 698761001690 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 698761001691 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698761001692 oligomeric interface; other site 698761001693 putative active site [active] 698761001694 homodimer interface [polypeptide binding]; other site 698761001695 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698761001696 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698761001697 putative active site [active] 698761001698 substrate binding site [chemical binding]; other site 698761001699 putative cosubstrate binding site; other site 698761001700 catalytic site [active] 698761001701 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698761001702 substrate binding site [chemical binding]; other site 698761001703 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698761001704 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698761001705 dimerization interface 3.5A [polypeptide binding]; other site 698761001706 active site 698761001707 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 698761001708 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 698761001709 metal binding site [ion binding]; metal-binding site 698761001710 dimer interface [polypeptide binding]; other site 698761001711 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 698761001712 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 698761001713 trimer interface [polypeptide binding]; other site 698761001714 active site 698761001715 substrate binding site [chemical binding]; other site 698761001716 CoA binding site [chemical binding]; other site 698761001717 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698761001718 S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100...; Region: S-100; cl08302 698761001719 Ca2+ binding site [ion binding]; other site 698761001720 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 698761001721 Ca2+ binding site [ion binding]; other site 698761001722 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 698761001723 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 698761001724 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 698761001725 tetramer interface [polypeptide binding]; other site 698761001726 active site 698761001727 Mg2+/Mn2+ binding site [ion binding]; other site 698761001728 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698761001729 homohexameric interface [polypeptide binding]; other site 698761001730 feedback inhibition sensing region; other site 698761001731 carbamate kinase; Reviewed; Region: PRK12686 698761001732 nucleotide binding site [chemical binding]; other site 698761001733 N-acetyl-L-glutamate binding site [chemical binding]; other site 698761001734 RNA polymerase sigma factor; Provisional; Region: PRK12514 698761001735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761001736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761001737 DNA binding residues [nucleotide binding] 698761001738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 698761001739 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698761001740 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 698761001741 Fasciclin domain; Region: Fasciclin; pfam02469 698761001742 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 698761001743 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 698761001744 G1 box; other site 698761001745 GTP/Mg2+ binding site [chemical binding]; other site 698761001746 Switch I region; other site 698761001747 G2 box; other site 698761001748 G3 box; other site 698761001749 Switch II region; other site 698761001750 G4 box; other site 698761001751 G5 box; other site 698761001752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761001753 putative DNA binding site [nucleotide binding]; other site 698761001754 putative Zn2+ binding site [ion binding]; other site 698761001755 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 698761001756 amphipathic channel; other site 698761001757 Asn-Pro-Ala signature motifs; other site 698761001758 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698761001759 ArsC family; Region: ArsC; pfam03960 698761001760 catalytic residues [active] 698761001761 membrane protein insertase; Provisional; Region: PRK01318 698761001762 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 698761001763 ribonuclease P; Reviewed; Region: rnpA; PRK01313 698761001764 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698761001765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761001766 dimerization interface [polypeptide binding]; other site 698761001767 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761001768 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761001769 dimer interface [polypeptide binding]; other site 698761001770 putative CheW interface [polypeptide binding]; other site 698761001771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761001772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698761001773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761001774 ATP binding site [chemical binding]; other site 698761001775 Mg2+ binding site [ion binding]; other site 698761001776 G-X-G motif; other site 698761001777 GSCFA family; Region: GSCFA; pfam08885 698761001778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761001779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761001780 putative substrate translocation pore; other site 698761001781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761001782 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761001783 MarR family; Region: MarR; pfam01047 698761001784 BA14K-like protein; Region: BA14K; pfam07886 698761001785 short chain dehydrogenase; Provisional; Region: PRK06197 698761001786 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 698761001787 putative NAD(P) binding site [chemical binding]; other site 698761001788 active site 698761001789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761001790 S-adenosylmethionine binding site [chemical binding]; other site 698761001791 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 698761001792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761001793 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761001794 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761001795 active site 698761001796 catalytic tetrad [active] 698761001797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 698761001798 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 698761001799 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 698761001800 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 698761001801 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698761001802 non-specific DNA interactions [nucleotide binding]; other site 698761001803 DNA binding site [nucleotide binding] 698761001804 sequence specific DNA binding site [nucleotide binding]; other site 698761001805 putative cAMP binding site [chemical binding]; other site 698761001806 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761001807 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761001808 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698761001809 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761001810 ligand binding site [chemical binding]; other site 698761001811 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761001812 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761001813 TM-ABC transporter signature motif; other site 698761001814 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761001815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761001816 Walker A/P-loop; other site 698761001817 ATP binding site [chemical binding]; other site 698761001818 Q-loop/lid; other site 698761001819 ABC transporter signature motif; other site 698761001820 Walker B; other site 698761001821 D-loop; other site 698761001822 H-loop/switch region; other site 698761001823 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 698761001824 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 698761001825 active site 698761001826 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 698761001827 active site 698761001828 substrate binding pocket [chemical binding]; other site 698761001829 dimer interface [polypeptide binding]; other site 698761001830 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761001831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761001832 metal binding site [ion binding]; metal-binding site 698761001833 active site 698761001834 I-site; other site 698761001835 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 698761001836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761001837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761001838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761001839 active site 698761001840 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761001841 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 698761001842 putative substrate binding site [chemical binding]; other site 698761001843 putative ATP binding site [chemical binding]; other site 698761001844 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698761001845 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698761001846 active site 698761001847 dimer interface [polypeptide binding]; other site 698761001848 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698761001849 dimer interface [polypeptide binding]; other site 698761001850 active site 698761001851 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 698761001852 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 698761001853 acyl-activating enzyme (AAE) consensus motif; other site 698761001854 putative AMP binding site [chemical binding]; other site 698761001855 putative active site [active] 698761001856 putative CoA binding site [chemical binding]; other site 698761001857 PRC-barrel domain; Region: PRC; pfam05239 698761001858 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761001859 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 698761001860 dimer interface [polypeptide binding]; other site 698761001861 active site 698761001862 metal binding site [ion binding]; metal-binding site 698761001863 glutathione binding site [chemical binding]; other site 698761001864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 698761001865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761001866 dimer interface [polypeptide binding]; other site 698761001867 conserved gate region; other site 698761001868 putative PBP binding loops; other site 698761001869 ABC-ATPase subunit interface; other site 698761001870 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 698761001871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761001872 Walker A/P-loop; other site 698761001873 ATP binding site [chemical binding]; other site 698761001874 Q-loop/lid; other site 698761001875 ABC transporter signature motif; other site 698761001876 Walker B; other site 698761001877 D-loop; other site 698761001878 H-loop/switch region; other site 698761001879 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 698761001880 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698761001881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761001882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761001884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698761001886 dimerization interface [polypeptide binding]; other site 698761001887 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698761001888 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698761001889 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 698761001890 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698761001891 FMN binding site [chemical binding]; other site 698761001892 substrate binding site [chemical binding]; other site 698761001893 putative catalytic residue [active] 698761001894 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 698761001895 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698761001896 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698761001897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761001898 dimer interface [polypeptide binding]; other site 698761001899 phosphorylation site [posttranslational modification] 698761001900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761001901 ATP binding site [chemical binding]; other site 698761001902 Mg2+ binding site [ion binding]; other site 698761001903 G-X-G motif; other site 698761001904 PBP superfamily domain; Region: PBP_like_2; pfam12849 698761001905 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 698761001906 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 698761001907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761001908 dimer interface [polypeptide binding]; other site 698761001909 conserved gate region; other site 698761001910 putative PBP binding loops; other site 698761001911 ABC-ATPase subunit interface; other site 698761001912 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 698761001913 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 698761001914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761001915 dimer interface [polypeptide binding]; other site 698761001916 conserved gate region; other site 698761001917 putative PBP binding loops; other site 698761001918 ABC-ATPase subunit interface; other site 698761001919 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 698761001920 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698761001921 Walker A/P-loop; other site 698761001922 ATP binding site [chemical binding]; other site 698761001923 Q-loop/lid; other site 698761001924 ABC transporter signature motif; other site 698761001925 Walker B; other site 698761001926 D-loop; other site 698761001927 H-loop/switch region; other site 698761001928 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698761001929 PhoU domain; Region: PhoU; pfam01895 698761001930 PhoU domain; Region: PhoU; pfam01895 698761001931 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 698761001932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761001933 active site 698761001934 phosphorylation site [posttranslational modification] 698761001935 intermolecular recognition site; other site 698761001936 dimerization interface [polypeptide binding]; other site 698761001937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761001938 DNA binding site [nucleotide binding] 698761001939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 698761001940 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 698761001941 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761001942 inhibitor-cofactor binding pocket; inhibition site 698761001943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761001944 catalytic residue [active] 698761001945 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698761001946 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698761001947 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698761001948 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 698761001949 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 698761001950 dimerization interface [polypeptide binding]; other site 698761001951 domain crossover interface; other site 698761001952 redox-dependent activation switch; other site 698761001953 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 698761001954 replicative DNA helicase; Provisional; Region: PRK05973 698761001955 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 698761001956 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 698761001957 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698761001958 homodimer interface [polypeptide binding]; other site 698761001959 substrate-cofactor binding pocket; other site 698761001960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761001961 catalytic residue [active] 698761001962 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 698761001963 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 698761001964 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698761001965 trimer interface [polypeptide binding]; other site 698761001966 active site 698761001967 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 698761001968 trimer interface [polypeptide binding]; other site 698761001969 active site 698761001970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761001971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761001972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698761001973 dimerization interface [polypeptide binding]; other site 698761001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761001975 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761001976 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698761001977 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 698761001978 trimer interface [polypeptide binding]; other site 698761001979 active site 698761001980 substrate binding site [chemical binding]; other site 698761001981 CoA binding site [chemical binding]; other site 698761001982 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761001983 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761001984 substrate binding pocket [chemical binding]; other site 698761001985 membrane-bound complex binding site; other site 698761001986 hinge residues; other site 698761001987 tellurite resistance protein terB; Region: terB; cd07176 698761001988 putative metal binding site [ion binding]; other site 698761001989 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698761001990 Predicted transcriptional regulator [Transcription]; Region: COG2932 698761001991 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698761001992 Catalytic site [active] 698761001993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 698761001994 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698761001995 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698761001996 quinone interaction residues [chemical binding]; other site 698761001997 active site 698761001998 catalytic residues [active] 698761001999 FMN binding site [chemical binding]; other site 698761002000 substrate binding site [chemical binding]; other site 698761002001 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 698761002002 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 698761002003 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 698761002004 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 698761002005 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 698761002006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761002007 TPR motif; other site 698761002008 binding surface 698761002009 Methyltransferase domain; Region: Methyltransf_12; pfam08242 698761002010 S-adenosylmethionine binding site [chemical binding]; other site 698761002011 Uncharacterized conserved protein [Function unknown]; Region: COG1284 698761002012 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698761002013 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 698761002014 glutamine synthetase; Region: PLN02284 698761002015 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698761002016 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698761002017 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698761002018 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698761002019 Rrf2 family protein; Region: rrf2_super; TIGR00738 698761002020 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761002021 dimerization interface [polypeptide binding]; other site 698761002022 putative Zn2+ binding site [ion binding]; other site 698761002023 putative DNA binding site [nucleotide binding]; other site 698761002024 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 698761002025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698761002026 ATP binding site [chemical binding]; other site 698761002027 putative Mg++ binding site [ion binding]; other site 698761002028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761002029 nucleotide binding region [chemical binding]; other site 698761002030 ATP-binding site [chemical binding]; other site 698761002031 DEAD/H associated; Region: DEAD_assoc; pfam08494 698761002032 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761002033 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 698761002034 putative active site [active] 698761002035 putative metal binding site [ion binding]; other site 698761002036 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698761002037 RibD C-terminal domain; Region: RibD_C; cl17279 698761002038 RibD C-terminal domain; Region: RibD_C; cl17279 698761002039 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761002040 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698761002041 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 698761002042 Predicted permeases [General function prediction only]; Region: COG0730 698761002043 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698761002044 Sel1-like repeats; Region: SEL1; smart00671 698761002045 Sel1-like repeats; Region: SEL1; smart00671 698761002046 Sel1-like repeats; Region: SEL1; smart00671 698761002047 Sel1-like repeats; Region: SEL1; smart00671 698761002048 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 698761002049 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761002050 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 698761002051 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 698761002052 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 698761002053 FAD binding site [chemical binding]; other site 698761002054 substrate binding site [chemical binding]; other site 698761002055 catalytic residues [active] 698761002056 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 698761002057 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 698761002058 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698761002059 dimer interface [polypeptide binding]; other site 698761002060 active site 698761002061 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 698761002062 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761002063 substrate binding site [chemical binding]; other site 698761002064 oxyanion hole (OAH) forming residues; other site 698761002065 trimer interface [polypeptide binding]; other site 698761002066 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698761002067 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698761002068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761002069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761002070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761002071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761002072 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 698761002073 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698761002074 aspartate aminotransferase; Provisional; Region: PRK06108 698761002075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761002076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761002077 homodimer interface [polypeptide binding]; other site 698761002078 catalytic residue [active] 698761002079 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698761002080 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698761002081 NAD binding site [chemical binding]; other site 698761002082 homodimer interface [polypeptide binding]; other site 698761002083 active site 698761002084 substrate binding site [chemical binding]; other site 698761002085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761002086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761002087 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698761002088 dimerization interface [polypeptide binding]; other site 698761002089 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 698761002090 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 698761002091 putative ligand binding site [chemical binding]; other site 698761002092 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761002093 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698761002094 Walker A/P-loop; other site 698761002095 ATP binding site [chemical binding]; other site 698761002096 Q-loop/lid; other site 698761002097 ABC transporter signature motif; other site 698761002098 Walker B; other site 698761002099 D-loop; other site 698761002100 H-loop/switch region; other site 698761002101 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698761002102 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698761002103 Walker A/P-loop; other site 698761002104 ATP binding site [chemical binding]; other site 698761002105 Q-loop/lid; other site 698761002106 ABC transporter signature motif; other site 698761002107 Walker B; other site 698761002108 D-loop; other site 698761002109 H-loop/switch region; other site 698761002110 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698761002111 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761002112 TM-ABC transporter signature motif; other site 698761002113 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698761002114 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698761002115 TM-ABC transporter signature motif; other site 698761002116 choline dehydrogenase; Validated; Region: PRK02106 698761002117 Predicted oxidoreductase [General function prediction only]; Region: COG3573 698761002118 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698761002119 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698761002120 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761002121 substrate binding site [chemical binding]; other site 698761002122 oxyanion hole (OAH) forming residues; other site 698761002123 trimer interface [polypeptide binding]; other site 698761002124 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 698761002125 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761002126 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 698761002127 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698761002128 Part of AAA domain; Region: AAA_19; pfam13245 698761002129 Family description; Region: UvrD_C_2; pfam13538 698761002130 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698761002131 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 698761002132 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 698761002133 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 698761002134 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 698761002135 Protein export membrane protein; Region: SecD_SecF; pfam02355 698761002136 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698761002137 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698761002138 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 698761002139 heme-binding site [chemical binding]; other site 698761002140 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761002141 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761002142 dimer interface [polypeptide binding]; other site 698761002143 putative CheW interface [polypeptide binding]; other site 698761002144 STAS domain; Region: STAS_2; pfam13466 698761002145 Response regulator receiver domain; Region: Response_reg; pfam00072 698761002146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761002147 active site 698761002148 phosphorylation site [posttranslational modification] 698761002149 intermolecular recognition site; other site 698761002150 dimerization interface [polypeptide binding]; other site 698761002151 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 698761002152 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 698761002153 putative binding surface; other site 698761002154 active site 698761002155 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 698761002156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761002157 ATP binding site [chemical binding]; other site 698761002158 Mg2+ binding site [ion binding]; other site 698761002159 G-X-G motif; other site 698761002160 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 698761002161 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 698761002162 putative CheA interaction surface; other site 698761002163 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 698761002164 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 698761002165 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 698761002166 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 698761002167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761002168 active site 698761002169 phosphorylation site [posttranslational modification] 698761002170 intermolecular recognition site; other site 698761002171 dimerization interface [polypeptide binding]; other site 698761002172 CheB methylesterase; Region: CheB_methylest; pfam01339 698761002173 Response regulator receiver domain; Region: Response_reg; pfam00072 698761002174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761002175 active site 698761002176 phosphorylation site [posttranslational modification] 698761002177 intermolecular recognition site; other site 698761002178 dimerization interface [polypeptide binding]; other site 698761002179 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497 698761002180 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 698761002181 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 698761002182 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 698761002183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761002184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761002185 DNA binding residues [nucleotide binding] 698761002186 dimerization interface [polypeptide binding]; other site 698761002187 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761002188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761002189 DNA binding residues [nucleotide binding] 698761002190 dimerization interface [polypeptide binding]; other site 698761002191 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 698761002192 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 698761002193 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 698761002194 MgtE intracellular N domain; Region: MgtE_N; smart00924 698761002195 FliG C-terminal domain; Region: FliG_C; pfam01706 698761002196 flagellar motor switch protein FliN; Region: fliN; TIGR02480 698761002197 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 698761002198 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 698761002199 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 698761002200 flagellar motor protein MotA; Validated; Region: PRK09110 698761002201 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 698761002202 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698761002203 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 698761002204 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 698761002205 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698761002206 Walker A motif; other site 698761002207 ATP binding site [chemical binding]; other site 698761002208 Walker B motif; other site 698761002209 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 698761002210 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 698761002211 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698761002212 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698761002213 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 698761002214 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 698761002215 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698761002216 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 698761002217 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 698761002218 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 698761002219 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 698761002220 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 698761002221 Uncharacterized conserved protein [Function unknown]; Region: COG3334 698761002222 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 698761002223 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 698761002224 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 698761002225 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 698761002226 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 698761002227 flagellin; Reviewed; Region: PRK12687 698761002228 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698761002229 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698761002230 flagellin; Reviewed; Region: PRK12687 698761002231 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698761002232 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698761002233 tyrosine decarboxylase; Region: PLN02880 698761002234 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698761002235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761002236 catalytic residue [active] 698761002237 flagellin; Reviewed; Region: PRK12687 698761002238 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698761002239 flagellin; Reviewed; Region: PRK12687 698761002240 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698761002241 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698761002242 flagellar motor protein MotB; Validated; Region: motB; PRK05996 698761002243 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 698761002244 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698761002245 ligand binding site [chemical binding]; other site 698761002246 chemotaxis protein; Reviewed; Region: PRK12798 698761002247 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 698761002248 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698761002249 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698761002250 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698761002251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761002252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761002253 DNA binding site [nucleotide binding] 698761002254 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 698761002255 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698761002256 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 698761002257 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698761002258 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 698761002259 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 698761002260 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 698761002261 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 698761002262 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 698761002263 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 698761002264 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 698761002265 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 698761002266 FHIPEP family; Region: FHIPEP; pfam00771 698761002267 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 698761002268 Rod binding protein; Region: Rod-binding; pfam10135 698761002269 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 698761002270 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 698761002271 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 698761002272 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 698761002273 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698761002274 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698761002275 homodimer interface [polypeptide binding]; other site 698761002276 NADP binding site [chemical binding]; other site 698761002277 substrate binding site [chemical binding]; other site 698761002278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761002279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761002280 DNA binding site [nucleotide binding] 698761002281 domain linker motif; other site 698761002282 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698761002283 ligand binding site [chemical binding]; other site 698761002284 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761002285 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761002286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698761002287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761002288 dimer interface [polypeptide binding]; other site 698761002289 putative PBP binding loops; other site 698761002290 ABC-ATPase subunit interface; other site 698761002291 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761002292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761002293 dimer interface [polypeptide binding]; other site 698761002294 conserved gate region; other site 698761002295 putative PBP binding loops; other site 698761002296 ABC-ATPase subunit interface; other site 698761002297 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 698761002298 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698761002299 active site 698761002300 catalytic site [active] 698761002301 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 698761002302 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761002303 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761002304 Walker A/P-loop; other site 698761002305 ATP binding site [chemical binding]; other site 698761002306 Q-loop/lid; other site 698761002307 ABC transporter signature motif; other site 698761002308 Walker B; other site 698761002309 D-loop; other site 698761002310 H-loop/switch region; other site 698761002311 TOBE domain; Region: TOBE_2; pfam08402 698761002312 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 698761002313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761002314 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 698761002315 6-phosphogluconate dehydratase; Region: edd; TIGR01196 698761002316 phosphogluconate dehydratase; Validated; Region: PRK09054 698761002317 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698761002318 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698761002319 putative active site [active] 698761002320 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698761002321 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698761002322 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698761002323 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698761002324 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761002325 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698761002326 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698761002327 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698761002328 Predicted flavoproteins [General function prediction only]; Region: COG2081 698761002329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761002330 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 698761002331 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 698761002332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761002333 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 698761002334 dimerization interface [polypeptide binding]; other site 698761002335 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761002336 dimer interface [polypeptide binding]; other site 698761002337 putative CheW interface [polypeptide binding]; other site 698761002338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761002339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761002340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761002341 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 698761002342 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761002343 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761002344 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 698761002345 Walker A/P-loop; other site 698761002346 ATP binding site [chemical binding]; other site 698761002347 Q-loop/lid; other site 698761002348 ABC transporter signature motif; other site 698761002349 Walker B; other site 698761002350 D-loop; other site 698761002351 H-loop/switch region; other site 698761002352 TOBE domain; Region: TOBE_2; pfam08402 698761002353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761002354 dimer interface [polypeptide binding]; other site 698761002355 conserved gate region; other site 698761002356 putative PBP binding loops; other site 698761002357 ABC-ATPase subunit interface; other site 698761002358 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761002359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761002360 dimer interface [polypeptide binding]; other site 698761002361 conserved gate region; other site 698761002362 putative PBP binding loops; other site 698761002363 ABC-ATPase subunit interface; other site 698761002364 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 698761002365 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 698761002366 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 698761002367 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 698761002368 acyl-activating enzyme (AAE) consensus motif; other site 698761002369 putative AMP binding site [chemical binding]; other site 698761002370 putative active site [active] 698761002371 putative CoA binding site [chemical binding]; other site 698761002372 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698761002373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698761002374 ATP binding site [chemical binding]; other site 698761002375 putative Mg++ binding site [ion binding]; other site 698761002376 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761002377 nucleotide binding region [chemical binding]; other site 698761002378 ATP-binding site [chemical binding]; other site 698761002379 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 698761002380 RNA binding site [nucleotide binding]; other site 698761002381 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761002382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761002383 S-adenosylmethionine binding site [chemical binding]; other site 698761002384 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 698761002385 active site residue [active] 698761002386 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 698761002387 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 698761002388 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 698761002389 Chromate transporter; Region: Chromate_transp; pfam02417 698761002390 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761002391 PAS domain; Region: PAS_8; pfam13188 698761002392 PAS domain; Region: PAS_9; pfam13426 698761002393 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698761002394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761002395 putative active site [active] 698761002396 heme pocket [chemical binding]; other site 698761002397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761002398 dimer interface [polypeptide binding]; other site 698761002399 phosphorylation site [posttranslational modification] 698761002400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761002401 ATP binding site [chemical binding]; other site 698761002402 Mg2+ binding site [ion binding]; other site 698761002403 G-X-G motif; other site 698761002404 Phasin protein; Region: Phasin_2; cl11491 698761002405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761002406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761002407 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698761002408 dimerization interface [polypeptide binding]; other site 698761002409 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 698761002410 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 698761002411 tetrameric interface [polypeptide binding]; other site 698761002412 NAD binding site [chemical binding]; other site 698761002413 catalytic residues [active] 698761002414 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698761002415 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 698761002416 Rrf2 family protein; Region: rrf2_super; TIGR00738 698761002417 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761002418 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 698761002419 peptide binding site [polypeptide binding]; other site 698761002420 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761002421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761002422 dimer interface [polypeptide binding]; other site 698761002423 conserved gate region; other site 698761002424 putative PBP binding loops; other site 698761002425 ABC-ATPase subunit interface; other site 698761002426 dipeptide transporter; Provisional; Region: PRK10913 698761002427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761002428 dimer interface [polypeptide binding]; other site 698761002429 conserved gate region; other site 698761002430 putative PBP binding loops; other site 698761002431 ABC-ATPase subunit interface; other site 698761002432 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698761002433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761002434 Walker A/P-loop; other site 698761002435 ATP binding site [chemical binding]; other site 698761002436 Q-loop/lid; other site 698761002437 ABC transporter signature motif; other site 698761002438 Walker B; other site 698761002439 D-loop; other site 698761002440 H-loop/switch region; other site 698761002441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761002442 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 698761002443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761002444 Walker A/P-loop; other site 698761002445 ATP binding site [chemical binding]; other site 698761002446 Q-loop/lid; other site 698761002447 ABC transporter signature motif; other site 698761002448 Walker B; other site 698761002449 D-loop; other site 698761002450 H-loop/switch region; other site 698761002451 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698761002452 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698761002453 AAA domain; Region: AAA_33; pfam13671 698761002454 ATP-binding site [chemical binding]; other site 698761002455 Gluconate-6-phosphate binding site [chemical binding]; other site 698761002456 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761002457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761002458 Phospholipid methyltransferase; Region: PEMT; cl17370 698761002459 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 698761002460 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 698761002461 malonyl-CoA binding site [chemical binding]; other site 698761002462 dimer interface [polypeptide binding]; other site 698761002463 active site 698761002464 product binding site; other site 698761002465 Tetratricopeptide repeat; Region: TPR_16; pfam13432 698761002466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761002467 TPR motif; other site 698761002468 binding surface 698761002469 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698761002470 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761002471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761002472 DNA binding residues [nucleotide binding] 698761002473 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698761002474 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698761002475 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761002476 nucleotide binding site [chemical binding]; other site 698761002477 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 698761002478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761002479 S-adenosylmethionine binding site [chemical binding]; other site 698761002480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761002481 putative substrate translocation pore; other site 698761002482 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698761002483 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698761002484 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698761002485 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698761002486 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698761002487 active site 698761002488 MAPEG family; Region: MAPEG; cl09190 698761002489 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 698761002490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761002491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761002492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761002493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761002494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761002495 dimerization interface [polypeptide binding]; other site 698761002496 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 698761002497 Dienelactone hydrolase family; Region: DLH; pfam01738 698761002498 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698761002499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761002500 Walker A/P-loop; other site 698761002501 ATP binding site [chemical binding]; other site 698761002502 ABC transporter signature motif; other site 698761002503 Walker B; other site 698761002504 D-loop; other site 698761002505 H-loop/switch region; other site 698761002506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761002507 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761002508 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761002509 active site 698761002510 catalytic tetrad [active] 698761002511 Uncharacterized conserved protein [Function unknown]; Region: COG5403 698761002512 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 698761002513 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761002514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 698761002515 RNA methyltransferase, RsmE family; Region: TIGR00046 698761002516 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698761002517 Phosphate transporter family; Region: PHO4; pfam01384 698761002518 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 698761002519 nudix motif; other site 698761002520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761002521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761002522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761002523 dimerization interface [polypeptide binding]; other site 698761002524 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 698761002525 NAD binding site [chemical binding]; other site 698761002526 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 698761002527 putative ADP-ribose binding site [chemical binding]; other site 698761002528 putative active site [active] 698761002529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761002530 transcriptional activator TtdR; Provisional; Region: PRK09801 698761002531 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761002532 putative effector binding pocket; other site 698761002533 dimerization interface [polypeptide binding]; other site 698761002534 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 698761002535 FAD binding domain; Region: FAD_binding_4; pfam01565 698761002536 FAD binding domain; Region: FAD_binding_4; pfam01565 698761002537 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 698761002538 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698761002539 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 698761002540 Cysteine-rich domain; Region: CCG; pfam02754 698761002541 Cysteine-rich domain; Region: CCG; pfam02754 698761002542 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 698761002543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698761002544 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761002545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698761002546 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761002547 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698761002548 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 698761002549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761002550 motif II; other site 698761002551 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761002552 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761002553 active site 698761002554 catalytic tetrad [active] 698761002555 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 698761002556 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698761002557 putative NAD(P) binding site [chemical binding]; other site 698761002558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761002559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761002560 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 698761002561 putative effector binding pocket; other site 698761002562 putative dimerization interface [polypeptide binding]; other site 698761002563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 698761002564 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 698761002565 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 698761002566 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698761002567 dimer interface [polypeptide binding]; other site 698761002568 motif 1; other site 698761002569 active site 698761002570 motif 2; other site 698761002571 motif 3; other site 698761002572 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698761002573 anticodon binding site; other site 698761002574 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 698761002575 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698761002576 motif 1; other site 698761002577 dimer interface [polypeptide binding]; other site 698761002578 active site 698761002579 motif 2; other site 698761002580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698761002581 motif 3; other site 698761002582 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 698761002583 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 698761002584 Predicted membrane protein [Function unknown]; Region: COG2259 698761002585 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 698761002586 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 698761002587 C-terminal domain interface [polypeptide binding]; other site 698761002588 GSH binding site (G-site) [chemical binding]; other site 698761002589 dimer interface [polypeptide binding]; other site 698761002590 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 698761002591 dimer interface [polypeptide binding]; other site 698761002592 N-terminal domain interface [polypeptide binding]; other site 698761002593 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698761002594 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698761002595 ring oligomerisation interface [polypeptide binding]; other site 698761002596 ATP/Mg binding site [chemical binding]; other site 698761002597 stacking interactions; other site 698761002598 hinge regions; other site 698761002599 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698761002600 oligomerisation interface [polypeptide binding]; other site 698761002601 mobile loop; other site 698761002602 roof hairpin; other site 698761002603 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698761002604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761002605 active site 698761002606 motif I; other site 698761002607 motif II; other site 698761002608 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 698761002609 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698761002610 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698761002611 active site 698761002612 Riboflavin kinase; Region: Flavokinase; smart00904 698761002613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 698761002614 Cache domain; Region: Cache_2; pfam08269 698761002615 Histidine kinase; Region: HisKA_3; pfam07730 698761002616 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698761002617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761002618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761002619 active site 698761002620 phosphorylation site [posttranslational modification] 698761002621 intermolecular recognition site; other site 698761002622 dimerization interface [polypeptide binding]; other site 698761002623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761002624 DNA binding residues [nucleotide binding] 698761002625 dimerization interface [polypeptide binding]; other site 698761002626 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 698761002627 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 698761002628 Na binding site [ion binding]; other site 698761002629 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 698761002630 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698761002631 active site 698761002632 HIGH motif; other site 698761002633 nucleotide binding site [chemical binding]; other site 698761002634 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698761002635 active site 698761002636 KMSKS motif; other site 698761002637 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 698761002638 tRNA binding surface [nucleotide binding]; other site 698761002639 anticodon binding site; other site 698761002640 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698761002641 nucleoside/Zn binding site; other site 698761002642 dimer interface [polypeptide binding]; other site 698761002643 catalytic motif [active] 698761002644 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698761002645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698761002646 RNA binding surface [nucleotide binding]; other site 698761002647 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698761002648 active site 698761002649 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 698761002650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761002651 S-adenosylmethionine binding site [chemical binding]; other site 698761002652 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698761002653 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 698761002654 active site 698761002655 nucleophile elbow; other site 698761002656 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698761002657 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698761002658 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 698761002659 TrkA-N domain; Region: TrkA_N; pfam02254 698761002660 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 698761002661 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698761002662 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698761002663 active site 698761002664 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 698761002665 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 698761002666 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 698761002667 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698761002668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761002669 motif II; other site 698761002670 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 698761002671 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 698761002672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 698761002673 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 698761002674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761002675 ATP binding site [chemical binding]; other site 698761002676 Mg2+ binding site [ion binding]; other site 698761002677 G-X-G motif; other site 698761002678 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 698761002679 ATP binding site [chemical binding]; other site 698761002680 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 698761002681 PAS fold; Region: PAS_7; pfam12860 698761002682 PAS fold; Region: PAS_4; pfam08448 698761002683 Response regulator receiver domain; Region: Response_reg; pfam00072 698761002684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761002685 active site 698761002686 phosphorylation site [posttranslational modification] 698761002687 intermolecular recognition site; other site 698761002688 dimerization interface [polypeptide binding]; other site 698761002689 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761002690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761002691 metal binding site [ion binding]; metal-binding site 698761002692 active site 698761002693 I-site; other site 698761002694 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761002695 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698761002696 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 698761002697 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 698761002698 active site 698761002699 intersubunit interface [polypeptide binding]; other site 698761002700 catalytic residue [active] 698761002701 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 698761002702 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 698761002703 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698761002704 classical (c) SDRs; Region: SDR_c; cd05233 698761002705 NAD(P) binding site [chemical binding]; other site 698761002706 active site 698761002707 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698761002708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761002709 putative DNA binding site [nucleotide binding]; other site 698761002710 putative Zn2+ binding site [ion binding]; other site 698761002711 Bacterial transcriptional regulator; Region: IclR; pfam01614 698761002712 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698761002713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761002714 DNA binding residues [nucleotide binding] 698761002715 dimerization interface [polypeptide binding]; other site 698761002716 antiporter inner membrane protein; Provisional; Region: PRK11670 698761002717 Domain of unknown function DUF59; Region: DUF59; pfam01883 698761002718 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698761002719 Walker A motif; other site 698761002720 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698761002721 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 698761002722 Cl binding site [ion binding]; other site 698761002723 oligomer interface [polypeptide binding]; other site 698761002724 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 698761002725 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 698761002726 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 698761002727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 698761002728 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698761002729 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698761002730 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 698761002731 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698761002732 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698761002733 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 698761002734 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 698761002735 Phosphotransferase enzyme family; Region: APH; pfam01636 698761002736 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 698761002737 active site 698761002738 ATP binding site [chemical binding]; other site 698761002739 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698761002740 substrate binding site [chemical binding]; other site 698761002741 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698761002742 RNA/DNA hybrid binding site [nucleotide binding]; other site 698761002743 active site 698761002744 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 698761002745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761002746 FeS/SAM binding site; other site 698761002747 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 698761002748 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698761002749 MPT binding site; other site 698761002750 trimer interface [polypeptide binding]; other site 698761002751 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 698761002752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761002753 TPR motif; other site 698761002754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761002755 TPR motif; other site 698761002756 binding surface 698761002757 TPR repeat; Region: TPR_11; pfam13414 698761002758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761002759 binding surface 698761002760 TPR motif; other site 698761002761 TPR repeat; Region: TPR_11; pfam13414 698761002762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761002763 binding surface 698761002764 TPR motif; other site 698761002765 TPR repeat; Region: TPR_11; pfam13414 698761002766 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698761002767 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698761002768 substrate binding pocket [chemical binding]; other site 698761002769 chain length determination region; other site 698761002770 substrate-Mg2+ binding site; other site 698761002771 catalytic residues [active] 698761002772 aspartate-rich region 1; other site 698761002773 active site lid residues [active] 698761002774 aspartate-rich region 2; other site 698761002775 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 698761002776 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 698761002777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761002778 S-adenosylmethionine binding site [chemical binding]; other site 698761002779 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 698761002780 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 698761002781 tandem repeat interface [polypeptide binding]; other site 698761002782 oligomer interface [polypeptide binding]; other site 698761002783 active site residues [active] 698761002784 Virus attachment protein p12 family; Region: P12; pfam12669 698761002785 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 698761002786 dimer interface [polypeptide binding]; other site 698761002787 motif 1; other site 698761002788 active site 698761002789 motif 2; other site 698761002790 motif 3; other site 698761002791 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 698761002792 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698761002793 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698761002794 hinge; other site 698761002795 active site 698761002796 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 698761002797 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 698761002798 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 698761002799 Uncharacterized conserved protein [Function unknown]; Region: COG1683 698761002800 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 698761002801 HAMP domain; Region: HAMP; pfam00672 698761002802 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 698761002803 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761002804 dimer interface [polypeptide binding]; other site 698761002805 putative CheW interface [polypeptide binding]; other site 698761002806 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698761002807 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698761002808 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698761002809 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698761002810 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698761002811 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698761002812 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698761002813 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 698761002814 RNA binding site [nucleotide binding]; other site 698761002815 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698761002816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698761002817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761002818 S-adenosylmethionine binding site [chemical binding]; other site 698761002819 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 698761002820 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 698761002821 UbiA prenyltransferase family; Region: UbiA; pfam01040 698761002822 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761002823 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761002824 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761002825 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761002826 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761002827 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761002828 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761002829 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698761002830 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698761002831 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698761002832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 698761002833 MOSC domain; Region: MOSC; pfam03473 698761002834 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698761002835 FAD binding domain; Region: FAD_binding_4; pfam01565 698761002836 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698761002837 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 698761002838 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698761002839 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 698761002840 [2Fe-2S] cluster binding site [ion binding]; other site 698761002841 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 698761002842 putative alpha subunit interface [polypeptide binding]; other site 698761002843 putative active site [active] 698761002844 putative substrate binding site [chemical binding]; other site 698761002845 Fe binding site [ion binding]; other site 698761002846 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698761002847 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 698761002848 FAD binding pocket [chemical binding]; other site 698761002849 FAD binding motif [chemical binding]; other site 698761002850 phosphate binding motif [ion binding]; other site 698761002851 beta-alpha-beta structure motif; other site 698761002852 NAD binding pocket [chemical binding]; other site 698761002853 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761002854 catalytic loop [active] 698761002855 iron binding site [ion binding]; other site 698761002856 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698761002857 active site 698761002858 BA14K-like protein; Region: BA14K; pfam07886 698761002859 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698761002860 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 698761002861 Cl binding site [ion binding]; other site 698761002862 oligomer interface [polypeptide binding]; other site 698761002863 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761002864 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761002865 active site 698761002866 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 698761002867 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761002868 substrate binding site [chemical binding]; other site 698761002869 oxyanion hole (OAH) forming residues; other site 698761002870 trimer interface [polypeptide binding]; other site 698761002871 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698761002872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761002873 S-adenosylmethionine binding site [chemical binding]; other site 698761002874 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698761002875 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698761002876 RNA binding surface [nucleotide binding]; other site 698761002877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761002878 S-adenosylmethionine binding site [chemical binding]; other site 698761002879 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 698761002880 CHASE3 domain; Region: CHASE3; cl05000 698761002881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698761002882 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761002883 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761002884 dimer interface [polypeptide binding]; other site 698761002885 putative CheW interface [polypeptide binding]; other site 698761002886 GAF domain; Region: GAF; pfam01590 698761002887 GAF domain; Region: GAF_2; pfam13185 698761002888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761002889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761002890 metal binding site [ion binding]; metal-binding site 698761002891 active site 698761002892 I-site; other site 698761002893 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 698761002894 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698761002895 TPP-binding site; other site 698761002896 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698761002897 PYR/PP interface [polypeptide binding]; other site 698761002898 dimer interface [polypeptide binding]; other site 698761002899 TPP binding site [chemical binding]; other site 698761002900 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698761002901 Pirin-related protein [General function prediction only]; Region: COG1741 698761002902 Pirin; Region: Pirin; pfam02678 698761002903 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 698761002904 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 698761002905 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 698761002906 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 698761002907 putative active site [active] 698761002908 Zn binding site [ion binding]; other site 698761002909 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698761002910 active site 2 [active] 698761002911 active site 1 [active] 698761002912 BioY family; Region: BioY; pfam02632 698761002913 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698761002914 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698761002915 Walker A/P-loop; other site 698761002916 ATP binding site [chemical binding]; other site 698761002917 Q-loop/lid; other site 698761002918 ABC transporter signature motif; other site 698761002919 Walker B; other site 698761002920 D-loop; other site 698761002921 H-loop/switch region; other site 698761002922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 698761002923 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 698761002924 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 698761002925 active site 698761002926 dimer interface [polypeptide binding]; other site 698761002927 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 698761002928 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698761002929 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761002930 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 698761002931 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698761002932 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 698761002933 dimerization interface [polypeptide binding]; other site 698761002934 active site 698761002935 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698761002936 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698761002937 Tetramer interface [polypeptide binding]; other site 698761002938 active site 698761002939 FMN-binding site [chemical binding]; other site 698761002940 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 698761002941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761002942 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761002943 putative transposase OrfB; Reviewed; Region: PHA02517 698761002944 HTH-like domain; Region: HTH_21; pfam13276 698761002945 Integrase core domain; Region: rve; pfam00665 698761002946 Integrase core domain; Region: rve_2; pfam13333 698761002947 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698761002948 catalytic core [active] 698761002949 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 698761002950 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 698761002951 NAD binding site [chemical binding]; other site 698761002952 homotetramer interface [polypeptide binding]; other site 698761002953 homodimer interface [polypeptide binding]; other site 698761002954 substrate binding site [chemical binding]; other site 698761002955 active site 698761002956 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 698761002957 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698761002958 HSP70 interaction site [polypeptide binding]; other site 698761002959 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698761002960 dimer interface [polypeptide binding]; other site 698761002961 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 698761002962 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 698761002963 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 698761002964 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698761002965 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698761002966 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 698761002967 putative active site [active] 698761002968 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698761002969 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698761002970 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 698761002971 metal binding site [ion binding]; metal-binding site 698761002972 protease TldD; Provisional; Region: tldD; PRK10735 698761002973 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 698761002974 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698761002975 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 698761002976 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698761002977 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 698761002978 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 698761002979 Subunit I/III interface [polypeptide binding]; other site 698761002980 D-pathway; other site 698761002981 Subunit I/VIIc interface [polypeptide binding]; other site 698761002982 Subunit I/IV interface [polypeptide binding]; other site 698761002983 Subunit I/II interface [polypeptide binding]; other site 698761002984 Low-spin heme (heme a) binding site [chemical binding]; other site 698761002985 Subunit I/VIIa interface [polypeptide binding]; other site 698761002986 Subunit I/VIa interface [polypeptide binding]; other site 698761002987 Dimer interface; other site 698761002988 Putative water exit pathway; other site 698761002989 Binuclear center (heme a3/CuB) [ion binding]; other site 698761002990 K-pathway; other site 698761002991 Subunit I/Vb interface [polypeptide binding]; other site 698761002992 Putative proton exit pathway; other site 698761002993 Subunit I/VIb interface; other site 698761002994 Subunit I/VIc interface [polypeptide binding]; other site 698761002995 Electron transfer pathway; other site 698761002996 Subunit I/VIIIb interface [polypeptide binding]; other site 698761002997 Subunit I/VIIb interface [polypeptide binding]; other site 698761002998 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698761002999 UbiA prenyltransferase family; Region: UbiA; pfam01040 698761003000 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 698761003001 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 698761003002 Subunit III/VIIa interface [polypeptide binding]; other site 698761003003 Phospholipid binding site [chemical binding]; other site 698761003004 Subunit I/III interface [polypeptide binding]; other site 698761003005 Subunit III/VIb interface [polypeptide binding]; other site 698761003006 Subunit III/VIa interface; other site 698761003007 Subunit III/Vb interface [polypeptide binding]; other site 698761003008 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761003009 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761003010 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698761003011 active site 698761003012 metal binding site [ion binding]; metal-binding site 698761003013 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 698761003014 P-loop motif; other site 698761003015 ATP binding site [chemical binding]; other site 698761003016 Chloramphenicol (Cm) binding site [chemical binding]; other site 698761003017 catalytic residue [active] 698761003018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 698761003019 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698761003020 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 698761003021 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 698761003022 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 698761003023 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 698761003024 putative active site [active] 698761003025 putative substrate binding site [chemical binding]; other site 698761003026 ATP binding site [chemical binding]; other site 698761003027 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 698761003028 RNA/DNA hybrid binding site [nucleotide binding]; other site 698761003029 active site 698761003030 putative acetyltransferase; Provisional; Region: PRK03624 698761003031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761003032 Coenzyme A binding pocket [chemical binding]; other site 698761003033 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 698761003034 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698761003035 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698761003036 inhibitor site; inhibition site 698761003037 active site 698761003038 dimer interface [polypeptide binding]; other site 698761003039 catalytic residue [active] 698761003040 Lysine efflux permease [General function prediction only]; Region: COG1279 698761003041 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698761003042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761003043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761003044 dimerization interface [polypeptide binding]; other site 698761003045 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 698761003046 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698761003047 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698761003048 intersubunit interface [polypeptide binding]; other site 698761003049 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698761003050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698761003051 ABC-ATPase subunit interface; other site 698761003052 dimer interface [polypeptide binding]; other site 698761003053 putative PBP binding regions; other site 698761003054 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698761003055 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698761003056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761003057 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698761003058 active site 698761003059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761003060 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761003061 Integrase core domain; Region: rve; pfam00665 698761003062 Integrase core domain; Region: rve_2; pfam13333 698761003063 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 698761003064 catalytic triad [active] 698761003065 dimer interface [polypeptide binding]; other site 698761003066 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 698761003067 hypothetical protein; Validated; Region: PRK00228 698761003068 CsbD-like; Region: CsbD; pfam05532 698761003069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 698761003070 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 698761003071 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 698761003072 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 698761003073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761003074 PAS fold; Region: PAS_3; pfam08447 698761003075 putative active site [active] 698761003076 heme pocket [chemical binding]; other site 698761003077 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761003078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761003079 metal binding site [ion binding]; metal-binding site 698761003080 active site 698761003081 I-site; other site 698761003082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761003083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761003084 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698761003085 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698761003086 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 698761003087 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698761003088 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698761003089 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 698761003090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761003091 catalytic residue [active] 698761003092 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 698761003093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761003094 motif II; other site 698761003095 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698761003096 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761003097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761003098 DNA-binding site [nucleotide binding]; DNA binding site 698761003099 FCD domain; Region: FCD; pfam07729 698761003100 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 698761003101 Uncharacterized conserved protein [Function unknown]; Region: COG3543 698761003102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761003103 dimerization interface [polypeptide binding]; other site 698761003104 putative DNA binding site [nucleotide binding]; other site 698761003105 putative Zn2+ binding site [ion binding]; other site 698761003106 NIPSNAP; Region: NIPSNAP; pfam07978 698761003107 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698761003108 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 698761003109 DNA methylase; Region: N6_N4_Mtase; pfam01555 698761003110 SnoaL-like domain; Region: SnoaL_2; pfam12680 698761003111 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 698761003112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761003113 motif II; other site 698761003114 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 698761003115 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698761003116 minor groove reading motif; other site 698761003117 helix-hairpin-helix signature motif; other site 698761003118 substrate binding pocket [chemical binding]; other site 698761003119 active site 698761003120 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698761003121 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 698761003122 DNA binding and oxoG recognition site [nucleotide binding] 698761003123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 698761003124 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698761003125 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698761003126 catalytic residues [active] 698761003127 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 698761003128 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698761003129 Walker A/P-loop; other site 698761003130 ATP binding site [chemical binding]; other site 698761003131 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698761003132 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 698761003133 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698761003134 ABC transporter signature motif; other site 698761003135 Walker B; other site 698761003136 D-loop; other site 698761003137 H-loop/switch region; other site 698761003138 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698761003139 Domain of unknown function DUF21; Region: DUF21; pfam01595 698761003140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698761003141 Transporter associated domain; Region: CorC_HlyC; smart01091 698761003142 pyruvate phosphate dikinase; Provisional; Region: PRK09279 698761003143 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 698761003144 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698761003145 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698761003146 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 698761003147 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698761003148 Cupin domain; Region: Cupin_2; cl17218 698761003149 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 698761003150 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 698761003151 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 698761003152 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 698761003153 GAF domain; Region: GAF_2; pfam13185 698761003154 methionine sulfoxide reductase B; Provisional; Region: PRK00222 698761003155 SelR domain; Region: SelR; pfam01641 698761003156 methionine sulfoxide reductase A; Provisional; Region: PRK14054 698761003157 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 698761003158 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 698761003159 Porin subfamily; Region: Porin_2; pfam02530 698761003160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761003161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761003162 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 698761003163 putative effector binding pocket; other site 698761003164 putative dimerization interface [polypeptide binding]; other site 698761003165 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 698761003166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761003167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761003168 homodimer interface [polypeptide binding]; other site 698761003169 catalytic residue [active] 698761003170 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 698761003171 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 698761003172 CysD dimerization site [polypeptide binding]; other site 698761003173 G1 box; other site 698761003174 putative GEF interaction site [polypeptide binding]; other site 698761003175 GTP/Mg2+ binding site [chemical binding]; other site 698761003176 Switch I region; other site 698761003177 G2 box; other site 698761003178 G3 box; other site 698761003179 Switch II region; other site 698761003180 G4 box; other site 698761003181 G5 box; other site 698761003182 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 698761003183 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 698761003184 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 698761003185 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698761003186 Active Sites [active] 698761003187 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 698761003188 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698761003189 Active Sites [active] 698761003190 Predicted transcriptional regulator [Transcription]; Region: COG1959 698761003191 Transcriptional regulator; Region: Rrf2; pfam02082 698761003192 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 698761003193 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 698761003194 putative ion selectivity filter; other site 698761003195 putative pore gating glutamate residue; other site 698761003196 putative H+/Cl- coupling transport residue; other site 698761003197 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 698761003198 choline dehydrogenase; Validated; Region: PRK02106 698761003199 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698761003200 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 698761003201 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 698761003202 tetrameric interface [polypeptide binding]; other site 698761003203 NAD binding site [chemical binding]; other site 698761003204 catalytic residues [active] 698761003205 transcriptional regulator BetI; Validated; Region: PRK00767 698761003206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761003207 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 698761003208 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 698761003209 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 698761003210 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761003211 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698761003212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761003213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761003214 metal binding site [ion binding]; metal-binding site 698761003215 active site 698761003216 I-site; other site 698761003217 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698761003218 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698761003219 NAD(P) binding site [chemical binding]; other site 698761003220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761003221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761003222 putative substrate translocation pore; other site 698761003223 Predicted transcriptional regulator [Transcription]; Region: COG2345 698761003224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 698761003225 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 698761003226 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 698761003227 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761003228 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698761003229 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761003230 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 698761003231 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 698761003232 glutathionine S-transferase; Provisional; Region: PRK10542 698761003233 C-terminal domain interface [polypeptide binding]; other site 698761003234 GSH binding site (G-site) [chemical binding]; other site 698761003235 dimer interface [polypeptide binding]; other site 698761003236 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 698761003237 dimer interface [polypeptide binding]; other site 698761003238 N-terminal domain interface [polypeptide binding]; other site 698761003239 substrate binding pocket (H-site) [chemical binding]; other site 698761003240 Protein of unknown function (DUF419); Region: DUF419; cl15265 698761003241 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761003242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761003243 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698761003244 dimerization interface [polypeptide binding]; other site 698761003245 substrate binding pocket [chemical binding]; other site 698761003246 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761003247 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 698761003248 putative C-terminal domain interface [polypeptide binding]; other site 698761003249 putative GSH binding site (G-site) [chemical binding]; other site 698761003250 putative dimer interface [polypeptide binding]; other site 698761003251 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 698761003252 dimer interface [polypeptide binding]; other site 698761003253 N-terminal domain interface [polypeptide binding]; other site 698761003254 putative substrate binding pocket (H-site) [chemical binding]; other site 698761003255 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 698761003256 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 698761003257 dimer interface [polypeptide binding]; other site 698761003258 PYR/PP interface [polypeptide binding]; other site 698761003259 TPP binding site [chemical binding]; other site 698761003260 substrate binding site [chemical binding]; other site 698761003261 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 698761003262 TPP-binding site [chemical binding]; other site 698761003263 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 698761003264 isovaleryl-CoA dehydrogenase; Region: PLN02519 698761003265 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 698761003266 substrate binding site [chemical binding]; other site 698761003267 FAD binding site [chemical binding]; other site 698761003268 catalytic base [active] 698761003269 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 698761003270 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698761003271 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698761003272 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698761003273 homotrimer interaction site [polypeptide binding]; other site 698761003274 putative active site [active] 698761003275 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698761003276 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698761003277 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698761003278 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698761003279 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698761003280 carboxyltransferase (CT) interaction site; other site 698761003281 biotinylation site [posttranslational modification]; other site 698761003282 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 698761003283 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 698761003284 active site 698761003285 catalytic residues [active] 698761003286 metal binding site [ion binding]; metal-binding site 698761003287 enoyl-CoA hydratase; Provisional; Region: PRK07468 698761003288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761003289 substrate binding site [chemical binding]; other site 698761003290 oxyanion hole (OAH) forming residues; other site 698761003291 trimer interface [polypeptide binding]; other site 698761003292 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 698761003293 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 698761003294 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698761003295 ATP-dependent DNA ligase; Validated; Region: PRK09247 698761003296 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 698761003297 active site 698761003298 DNA binding site [nucleotide binding] 698761003299 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 698761003300 DNA binding site [nucleotide binding] 698761003301 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 698761003302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761003303 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698761003304 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698761003305 active site 698761003306 substrate binding site [chemical binding]; other site 698761003307 coenzyme B12 binding site [chemical binding]; other site 698761003308 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698761003309 B12 binding site [chemical binding]; other site 698761003310 cobalt ligand [ion binding]; other site 698761003311 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698761003312 heterodimer interface [polypeptide binding]; other site 698761003313 substrate interaction site [chemical binding]; other site 698761003314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698761003315 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761003316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698761003317 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761003318 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 698761003319 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 698761003320 RES domain; Region: RES; smart00953 698761003321 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761003322 MarR family; Region: MarR_2; cl17246 698761003323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 698761003324 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698761003325 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761003326 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698761003327 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761003328 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 698761003329 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 698761003330 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698761003331 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698761003332 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 698761003333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761003334 S-adenosylmethionine binding site [chemical binding]; other site 698761003335 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698761003336 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 698761003337 putative NAD(P) binding site [chemical binding]; other site 698761003338 catalytic Zn binding site [ion binding]; other site 698761003339 structural Zn binding site [ion binding]; other site 698761003340 aminotransferase; Provisional; Region: PRK13356 698761003341 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698761003342 homodimer interface [polypeptide binding]; other site 698761003343 substrate-cofactor binding pocket; other site 698761003344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761003345 catalytic residue [active] 698761003346 glutathionine S-transferase; Provisional; Region: PRK10542 698761003347 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 698761003348 C-terminal domain interface [polypeptide binding]; other site 698761003349 GSH binding site (G-site) [chemical binding]; other site 698761003350 dimer interface [polypeptide binding]; other site 698761003351 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 698761003352 N-terminal domain interface [polypeptide binding]; other site 698761003353 dimer interface [polypeptide binding]; other site 698761003354 substrate binding pocket (H-site) [chemical binding]; other site 698761003355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761003356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761003357 drug efflux system protein MdtG; Provisional; Region: PRK09874 698761003358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761003359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761003360 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698761003361 substrate binding site [chemical binding]; other site 698761003362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761003363 SnoaL-like domain; Region: SnoaL_2; pfam12680 698761003364 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698761003365 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698761003366 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698761003367 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698761003368 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761003369 active site 698761003370 metal binding site [ion binding]; metal-binding site 698761003371 Predicted transcriptional regulator [Transcription]; Region: COG2378 698761003372 HTH domain; Region: HTH_11; pfam08279 698761003373 WYL domain; Region: WYL; pfam13280 698761003374 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761003375 Cytochrome C' Region: Cytochrom_C_2; cl01610 698761003376 Cytochrome c; Region: Cytochrom_C; pfam00034 698761003377 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698761003378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761003379 S-adenosylmethionine binding site [chemical binding]; other site 698761003380 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 698761003381 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698761003382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761003383 Coenzyme A binding pocket [chemical binding]; other site 698761003384 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 698761003385 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 698761003386 DNA binding residues [nucleotide binding] 698761003387 dimer interface [polypeptide binding]; other site 698761003388 putative metal binding site [ion binding]; other site 698761003389 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 698761003390 putative metal binding site [ion binding]; other site 698761003391 putative homodimer interface [polypeptide binding]; other site 698761003392 putative homotetramer interface [polypeptide binding]; other site 698761003393 putative homodimer-homodimer interface [polypeptide binding]; other site 698761003394 putative allosteric switch controlling residues; other site 698761003395 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698761003396 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698761003397 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 698761003398 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 698761003399 Uncharacterized conserved protein [Function unknown]; Region: COG0397 698761003400 hypothetical protein; Validated; Region: PRK00029 698761003401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 698761003402 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698761003403 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761003404 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 698761003405 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 698761003406 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698761003407 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 698761003408 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698761003409 HSP70 interaction site [polypeptide binding]; other site 698761003410 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698761003411 substrate binding site [polypeptide binding]; other site 698761003412 dimer interface [polypeptide binding]; other site 698761003413 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 698761003414 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 698761003415 NodB motif; other site 698761003416 putative active site [active] 698761003417 putative catalytic site [active] 698761003418 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698761003419 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698761003420 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 698761003421 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 698761003422 putative metal binding site [ion binding]; other site 698761003423 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698761003424 active site 698761003425 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698761003426 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698761003427 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 698761003428 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698761003429 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698761003430 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698761003431 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 698761003432 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 698761003433 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 698761003434 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698761003435 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 698761003436 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 698761003437 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 698761003438 Predicted transcriptional regulator [Transcription]; Region: COG4957 698761003439 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 698761003440 PAS fold; Region: PAS; pfam00989 698761003441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761003442 dimer interface [polypeptide binding]; other site 698761003443 phosphorylation site [posttranslational modification] 698761003444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761003445 ATP binding site [chemical binding]; other site 698761003446 Mg2+ binding site [ion binding]; other site 698761003447 G-X-G motif; other site 698761003448 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761003449 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761003450 Uncharacterized conserved protein [Function unknown]; Region: COG5447 698761003451 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 698761003452 Predicted integral membrane protein [Function unknown]; Region: COG5436 698761003453 Uncharacterized conserved protein [Function unknown]; Region: COG5402 698761003454 Transglycosylase; Region: Transgly; pfam00912 698761003455 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 698761003456 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698761003457 hypothetical protein; Provisional; Region: PRK05170 698761003458 Protein of unknown function (DUF419); Region: DUF419; pfam04237 698761003459 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 698761003460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761003461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761003462 active site 698761003463 phosphorylation site [posttranslational modification] 698761003464 intermolecular recognition site; other site 698761003465 dimerization interface [polypeptide binding]; other site 698761003466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761003467 DNA binding site [nucleotide binding] 698761003468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761003469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761003470 ATP binding site [chemical binding]; other site 698761003471 Mg2+ binding site [ion binding]; other site 698761003472 G-X-G motif; other site 698761003473 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 698761003474 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 698761003475 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 698761003476 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 698761003477 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 698761003478 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 698761003479 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698761003480 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761003481 protein binding site [polypeptide binding]; other site 698761003482 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761003483 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761003484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761003485 active site 698761003486 phosphorylation site [posttranslational modification] 698761003487 intermolecular recognition site; other site 698761003488 dimerization interface [polypeptide binding]; other site 698761003489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761003490 DNA binding site [nucleotide binding] 698761003491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761003492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761003493 dimerization interface [polypeptide binding]; other site 698761003494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761003495 dimer interface [polypeptide binding]; other site 698761003496 phosphorylation site [posttranslational modification] 698761003497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761003498 ATP binding site [chemical binding]; other site 698761003499 Mg2+ binding site [ion binding]; other site 698761003500 G-X-G motif; other site 698761003501 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 698761003502 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698761003503 metal binding triad; other site 698761003504 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698761003505 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698761003506 metal binding triad; other site 698761003507 PAS fold; Region: PAS_3; pfam08447 698761003508 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 698761003509 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698761003510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761003511 dimer interface [polypeptide binding]; other site 698761003512 phosphorylation site [posttranslational modification] 698761003513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761003514 ATP binding site [chemical binding]; other site 698761003515 Mg2+ binding site [ion binding]; other site 698761003516 G-X-G motif; other site 698761003517 aminopeptidase N; Provisional; Region: pepN; PRK14015 698761003518 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 698761003519 active site 698761003520 Zn binding site [ion binding]; other site 698761003521 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 698761003522 Fe-S cluster binding site [ion binding]; other site 698761003523 active site 698761003524 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 698761003525 putative chaperone; Provisional; Region: PRK11678 698761003526 nucleotide binding site [chemical binding]; other site 698761003527 putative NEF/HSP70 interaction site [polypeptide binding]; other site 698761003528 SBD interface [polypeptide binding]; other site 698761003529 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698761003530 Protein export membrane protein; Region: SecD_SecF; cl14618 698761003531 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761003532 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761003533 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761003534 short chain dehydrogenase; Provisional; Region: PRK08339 698761003535 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 698761003536 putative NAD(P) binding site [chemical binding]; other site 698761003537 putative active site [active] 698761003538 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 698761003539 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761003540 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 698761003541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761003542 Coenzyme A binding pocket [chemical binding]; other site 698761003543 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761003544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761003545 dimerization interface [polypeptide binding]; other site 698761003546 putative DNA binding site [nucleotide binding]; other site 698761003547 putative Zn2+ binding site [ion binding]; other site 698761003548 AsnC family; Region: AsnC_trans_reg; pfam01037 698761003549 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698761003550 MgtE intracellular N domain; Region: MgtE_N; pfam03448 698761003551 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698761003552 Divalent cation transporter; Region: MgtE; pfam01769 698761003553 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 698761003554 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 698761003555 putative NAD(P) binding site [chemical binding]; other site 698761003556 dimer interface [polypeptide binding]; other site 698761003557 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761003558 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698761003559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761003560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761003561 putative substrate translocation pore; other site 698761003562 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698761003563 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698761003564 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698761003565 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698761003566 putative aminotransferase; Validated; Region: PRK07480 698761003567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761003568 inhibitor-cofactor binding pocket; inhibition site 698761003569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761003570 catalytic residue [active] 698761003571 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698761003572 dimer interface [polypeptide binding]; other site 698761003573 ADP-ribose binding site [chemical binding]; other site 698761003574 active site 698761003575 nudix motif; other site 698761003576 metal binding site [ion binding]; metal-binding site 698761003577 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 698761003578 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 698761003579 Ligand binding site; other site 698761003580 Putative Catalytic site; other site 698761003581 DXD motif; other site 698761003582 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 698761003583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761003584 DNA binding residues [nucleotide binding] 698761003585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 698761003586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 698761003587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 698761003588 AMP nucleosidase; Provisional; Region: PRK08292 698761003589 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 698761003590 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 698761003591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 698761003592 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698761003593 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 698761003594 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761003595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761003596 homodimer interface [polypeptide binding]; other site 698761003597 catalytic residue [active] 698761003598 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698761003599 active site 698761003600 substrate binding site [chemical binding]; other site 698761003601 cosubstrate binding site; other site 698761003602 catalytic site [active] 698761003603 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698761003604 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761003605 NADP binding site [chemical binding]; other site 698761003606 active site 698761003607 steroid binding site; other site 698761003608 Cupin; Region: Cupin_6; pfam12852 698761003609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761003610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761003611 PilZ domain; Region: PilZ; cl01260 698761003612 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 698761003613 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698761003614 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 698761003615 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761003616 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 698761003617 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698761003618 PYR/PP interface [polypeptide binding]; other site 698761003619 dimer interface [polypeptide binding]; other site 698761003620 TPP binding site [chemical binding]; other site 698761003621 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698761003622 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 698761003623 TPP-binding site; other site 698761003624 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761003625 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698761003626 substrate binding site [chemical binding]; other site 698761003627 ATP binding site [chemical binding]; other site 698761003628 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 698761003629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 698761003630 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698761003631 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698761003632 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698761003633 putative active site [active] 698761003634 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761003635 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761003636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761003637 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 698761003638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761003639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761003640 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761003641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761003642 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698761003643 putative effector binding pocket; other site 698761003644 putative dimerization interface [polypeptide binding]; other site 698761003645 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698761003646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761003647 NAD(P) binding site [chemical binding]; other site 698761003648 active site 698761003649 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 698761003650 Porin subfamily; Region: Porin_2; pfam02530 698761003651 Porin subfamily; Region: Porin_2; pfam02530 698761003652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761003653 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698761003654 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698761003655 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698761003656 catalytic residue [active] 698761003657 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698761003658 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698761003659 dimer interface [polypeptide binding]; other site 698761003660 active site 698761003661 catalytic residue [active] 698761003662 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698761003663 SmpB-tmRNA interface; other site 698761003664 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698761003665 LabA_like proteins; Region: LabA; cd10911 698761003666 putative metal binding site [ion binding]; other site 698761003667 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 698761003668 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698761003669 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698761003670 Zn2+ binding site [ion binding]; other site 698761003671 Mg2+ binding site [ion binding]; other site 698761003672 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698761003673 synthetase active site [active] 698761003674 NTP binding site [chemical binding]; other site 698761003675 metal binding site [ion binding]; metal-binding site 698761003676 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698761003677 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698761003678 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 698761003679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 698761003680 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698761003681 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698761003682 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698761003683 Catalytic site [active] 698761003684 ribonuclease III; Reviewed; Region: PRK12371 698761003685 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698761003686 dimerization interface [polypeptide binding]; other site 698761003687 active site 698761003688 metal binding site [ion binding]; metal-binding site 698761003689 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698761003690 dsRNA binding site [nucleotide binding]; other site 698761003691 GTPase Era; Reviewed; Region: era; PRK00089 698761003692 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698761003693 G1 box; other site 698761003694 GTP/Mg2+ binding site [chemical binding]; other site 698761003695 Switch I region; other site 698761003696 G2 box; other site 698761003697 Switch II region; other site 698761003698 G3 box; other site 698761003699 G4 box; other site 698761003700 G5 box; other site 698761003701 KH domain; Region: KH_2; pfam07650 698761003702 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698761003703 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761003704 ligand binding site [chemical binding]; other site 698761003705 flexible hinge region; other site 698761003706 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698761003707 putative switch regulator; other site 698761003708 non-specific DNA interactions [nucleotide binding]; other site 698761003709 DNA binding site [nucleotide binding] 698761003710 sequence specific DNA binding site [nucleotide binding]; other site 698761003711 putative cAMP binding site [chemical binding]; other site 698761003712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761003713 active site 698761003714 phosphorylation site [posttranslational modification] 698761003715 intermolecular recognition site; other site 698761003716 dimerization interface [polypeptide binding]; other site 698761003717 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698761003718 Recombination protein O N terminal; Region: RecO_N; pfam11967 698761003719 Recombination protein O C terminal; Region: RecO_C; pfam02565 698761003720 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 698761003721 putative catalytic residues [active] 698761003722 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 698761003723 Double zinc ribbon; Region: DZR; pfam12773 698761003724 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 698761003725 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761003726 cyclase homology domain; Region: CHD; cd07302 698761003727 nucleotidyl binding site; other site 698761003728 metal binding site [ion binding]; metal-binding site 698761003729 dimer interface [polypeptide binding]; other site 698761003730 AAA ATPase domain; Region: AAA_16; pfam13191 698761003731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761003732 TPR motif; other site 698761003733 Tetratricopeptide repeat; Region: TPR_12; pfam13424 698761003734 binding surface 698761003735 Tetratricopeptide repeat; Region: TPR_12; pfam13424 698761003736 Tetratricopeptide repeat; Region: TPR_12; pfam13424 698761003737 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 698761003738 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 698761003739 MOSC domain; Region: MOSC; pfam03473 698761003740 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 698761003741 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698761003742 Zn2+ binding site [ion binding]; other site 698761003743 Mg2+ binding site [ion binding]; other site 698761003744 Predicted membrane protein [Function unknown]; Region: COG5373 698761003745 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698761003746 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698761003747 E-class dimer interface [polypeptide binding]; other site 698761003748 P-class dimer interface [polypeptide binding]; other site 698761003749 active site 698761003750 Cu2+ binding site [ion binding]; other site 698761003751 Zn2+ binding site [ion binding]; other site 698761003752 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 698761003753 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 698761003754 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698761003755 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698761003756 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761003757 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 698761003758 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 698761003759 nudix motif; other site 698761003760 hypothetical protein; Provisional; Region: PRK02237 698761003761 Uncharacterized conserved protein [Function unknown]; Region: COG2135 698761003762 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 698761003763 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 698761003764 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 698761003765 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 698761003766 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 698761003767 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698761003768 active site 698761003769 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761003770 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 698761003771 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 698761003772 Walker A/P-loop; other site 698761003773 ATP binding site [chemical binding]; other site 698761003774 Q-loop/lid; other site 698761003775 ABC transporter signature motif; other site 698761003776 Walker B; other site 698761003777 D-loop; other site 698761003778 H-loop/switch region; other site 698761003779 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 698761003780 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698761003781 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698761003782 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698761003783 EamA-like transporter family; Region: EamA; pfam00892 698761003784 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 698761003785 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 698761003786 active site 698761003787 catalytic residues [active] 698761003788 metal binding site [ion binding]; metal-binding site 698761003789 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698761003790 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698761003791 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761003792 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761003793 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761003794 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 698761003795 putative active site [active] 698761003796 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698761003797 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698761003798 active site 698761003799 HIGH motif; other site 698761003800 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698761003801 KMSKS motif; other site 698761003802 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698761003803 anticodon binding site; other site 698761003804 tRNA binding surface [nucleotide binding]; other site 698761003805 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761003806 classical (c) SDRs; Region: SDR_c; cd05233 698761003807 NAD(P) binding site [chemical binding]; other site 698761003808 active site 698761003809 amidophosphoribosyltransferase; Provisional; Region: PRK09123 698761003810 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698761003811 active site 698761003812 tetramer interface [polypeptide binding]; other site 698761003813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761003814 active site 698761003815 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 698761003816 Colicin V production protein; Region: Colicin_V; pfam02674 698761003817 DNA repair protein RadA; Provisional; Region: PRK11823 698761003818 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 698761003819 Walker A motif/ATP binding site; other site 698761003820 ATP binding site [chemical binding]; other site 698761003821 Walker B motif; other site 698761003822 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698761003823 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761003824 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 698761003825 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698761003826 active site 698761003827 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698761003828 dimer interface [polypeptide binding]; other site 698761003829 substrate binding site [chemical binding]; other site 698761003830 catalytic residues [active] 698761003831 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761003832 RibD C-terminal domain; Region: RibD_C; cl17279 698761003833 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761003834 dimerization interface [polypeptide binding]; other site 698761003835 putative DNA binding site [nucleotide binding]; other site 698761003836 putative Zn2+ binding site [ion binding]; other site 698761003837 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 698761003838 putative hydrophobic ligand binding site [chemical binding]; other site 698761003839 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761003840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761003841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761003842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761003843 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698761003844 Predicted membrane protein [Function unknown]; Region: COG4541 698761003845 replicative DNA helicase; Provisional; Region: PRK09165 698761003846 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698761003847 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698761003848 Walker A motif; other site 698761003849 ATP binding site [chemical binding]; other site 698761003850 Walker B motif; other site 698761003851 DNA binding loops [nucleotide binding] 698761003852 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761003853 MarR family; Region: MarR; pfam01047 698761003854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761003855 putative substrate translocation pore; other site 698761003856 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698761003857 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 698761003858 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761003859 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761003860 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698761003861 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698761003862 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698761003863 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 698761003864 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698761003865 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698761003866 catalytic core [active] 698761003867 Predicted periplasmic protein [Function unknown]; Region: COG3904 698761003868 Bacterial SH3 domain; Region: SH3_3; cl17532 698761003869 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761003870 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761003871 active site 698761003872 catalytic tetrad [active] 698761003873 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698761003874 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698761003875 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 698761003876 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 698761003877 NAD(P) binding site [chemical binding]; other site 698761003878 homotetramer interface [polypeptide binding]; other site 698761003879 homodimer interface [polypeptide binding]; other site 698761003880 active site 698761003881 acyl carrier protein; Provisional; Region: acpP; PRK00982 698761003882 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 698761003883 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698761003884 dimer interface [polypeptide binding]; other site 698761003885 active site 698761003886 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 698761003887 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698761003888 dimerization interface [polypeptide binding]; other site 698761003889 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 698761003890 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 698761003891 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 698761003892 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698761003893 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698761003894 catalytic site [active] 698761003895 G-X2-G-X-G-K; other site 698761003896 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698761003897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761003898 S-adenosylmethionine binding site [chemical binding]; other site 698761003899 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 698761003900 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 698761003901 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 698761003902 SurA N-terminal domain; Region: SurA_N; pfam09312 698761003903 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 698761003904 Organic solvent tolerance protein; Region: OstA_C; pfam04453 698761003905 Predicted permeases [General function prediction only]; Region: COG0795 698761003906 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 698761003907 Predicted permeases [General function prediction only]; Region: COG0795 698761003908 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 698761003909 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 698761003910 active site 698761003911 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698761003912 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698761003913 interface (dimer of trimers) [polypeptide binding]; other site 698761003914 Substrate-binding/catalytic site; other site 698761003915 Zn-binding sites [ion binding]; other site 698761003916 DNA polymerase III subunit chi; Validated; Region: PRK05728 698761003917 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 698761003918 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761003919 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761003920 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 698761003921 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 698761003922 DctM-like transporters; Region: DctM; pfam06808 698761003923 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 698761003924 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 698761003925 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 698761003926 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698761003927 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761003928 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698761003929 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 698761003930 NodB motif; other site 698761003931 active site 698761003932 catalytic site [active] 698761003933 metal binding site [ion binding]; metal-binding site 698761003934 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698761003935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761003936 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761003937 ABC transporter; Region: ABC_tran_2; pfam12848 698761003938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761003939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 698761003940 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698761003941 active site 698761003942 multimer interface [polypeptide binding]; other site 698761003943 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 698761003944 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 698761003945 CGNR zinc finger; Region: zf-CGNR; pfam11706 698761003946 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698761003947 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761003948 TM-ABC transporter signature motif; other site 698761003949 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698761003950 MoaE homodimer interface [polypeptide binding]; other site 698761003951 MoaD interaction [polypeptide binding]; other site 698761003952 active site residues [active] 698761003953 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 698761003954 MoaE interaction surface [polypeptide binding]; other site 698761003955 MoeB interaction surface [polypeptide binding]; other site 698761003956 thiocarboxylated glycine; other site 698761003957 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698761003958 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698761003959 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698761003960 GIY-YIG motif/motif A; other site 698761003961 active site 698761003962 catalytic site [active] 698761003963 putative DNA binding site [nucleotide binding]; other site 698761003964 metal binding site [ion binding]; metal-binding site 698761003965 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698761003966 short chain dehydrogenase; Provisional; Region: PRK09134 698761003967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761003968 NAD(P) binding site [chemical binding]; other site 698761003969 active site 698761003970 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698761003971 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761003972 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 698761003973 putative C-terminal domain interface [polypeptide binding]; other site 698761003974 putative GSH binding site (G-site) [chemical binding]; other site 698761003975 putative dimer interface [polypeptide binding]; other site 698761003976 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 698761003977 N-terminal domain interface [polypeptide binding]; other site 698761003978 dimer interface [polypeptide binding]; other site 698761003979 putative substrate binding pocket (H-site) [chemical binding]; other site 698761003980 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 698761003981 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 698761003982 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 698761003983 putative [4Fe-4S] binding site [ion binding]; other site 698761003984 putative molybdopterin cofactor binding site [chemical binding]; other site 698761003985 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 698761003986 putative molybdopterin cofactor binding site; other site 698761003987 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 698761003988 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698761003989 dimer interface [polypeptide binding]; other site 698761003990 ADP-ribose binding site [chemical binding]; other site 698761003991 active site 698761003992 nudix motif; other site 698761003993 metal binding site [ion binding]; metal-binding site 698761003994 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 698761003995 Amidohydrolase; Region: Amidohydro_5; pfam13594 698761003996 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761003997 active site 698761003998 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698761003999 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698761004000 active site 698761004001 substrate binding site [chemical binding]; other site 698761004002 cosubstrate binding site; other site 698761004003 catalytic site [active] 698761004004 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698761004005 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698761004006 dimerization interface [polypeptide binding]; other site 698761004007 putative ATP binding site [chemical binding]; other site 698761004008 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698761004009 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698761004010 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 698761004011 hypothetical protein; Validated; Region: PRK09087 698761004012 polyphosphate kinase; Provisional; Region: PRK05443 698761004013 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 698761004014 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 698761004015 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 698761004016 putative domain interface [polypeptide binding]; other site 698761004017 putative active site [active] 698761004018 catalytic site [active] 698761004019 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 698761004020 putative domain interface [polypeptide binding]; other site 698761004021 putative active site [active] 698761004022 catalytic site [active] 698761004023 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 698761004024 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 698761004025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 698761004026 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 698761004027 cyclase homology domain; Region: CHD; cd07302 698761004028 nucleotidyl binding site; other site 698761004029 metal binding site [ion binding]; metal-binding site 698761004030 dimer interface [polypeptide binding]; other site 698761004031 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698761004032 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698761004033 catalytic site [active] 698761004034 putative active site [active] 698761004035 putative substrate binding site [chemical binding]; other site 698761004036 HRDC domain; Region: HRDC; pfam00570 698761004037 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698761004038 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698761004039 Multicopper oxidase; Region: Cu-oxidase; pfam00394 698761004040 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 698761004041 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698761004042 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698761004043 dimer interface [polypeptide binding]; other site 698761004044 anticodon binding site; other site 698761004045 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698761004046 homodimer interface [polypeptide binding]; other site 698761004047 motif 1; other site 698761004048 active site 698761004049 motif 2; other site 698761004050 GAD domain; Region: GAD; pfam02938 698761004051 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698761004052 active site 698761004053 motif 3; other site 698761004054 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698761004055 Beta-lactamase; Region: Beta-lactamase; pfam00144 698761004056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761004057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761004058 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 698761004059 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698761004060 CAP-like domain; other site 698761004061 active site 698761004062 primary dimer interface [polypeptide binding]; other site 698761004063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698761004064 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 698761004065 putative addiction module antidote; Region: doc_partner; TIGR02609 698761004066 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761004067 EamA-like transporter family; Region: EamA; pfam00892 698761004068 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 698761004069 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 698761004070 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 698761004071 Predicted membrane protein/domain [Function unknown]; Region: COG1714 698761004072 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 698761004073 dimer interface [polypeptide binding]; other site 698761004074 allosteric magnesium binding site [ion binding]; other site 698761004075 active site 698761004076 aspartate-rich active site metal binding site; other site 698761004077 Schiff base residues; other site 698761004078 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761004079 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 698761004080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 698761004081 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761004082 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761004083 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698761004084 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698761004085 dimer interface [polypeptide binding]; other site 698761004086 active site 698761004087 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698761004088 folate binding site [chemical binding]; other site 698761004089 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698761004090 ATP cone domain; Region: ATP-cone; pfam03477 698761004091 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698761004092 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698761004093 catalytic motif [active] 698761004094 Zn binding site [ion binding]; other site 698761004095 RibD C-terminal domain; Region: RibD_C; cl17279 698761004096 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698761004097 Lumazine binding domain; Region: Lum_binding; pfam00677 698761004098 Lumazine binding domain; Region: Lum_binding; pfam00677 698761004099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761004100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761004101 Coenzyme A binding pocket [chemical binding]; other site 698761004102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761004103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761004104 Coenzyme A binding pocket [chemical binding]; other site 698761004105 Cupin domain; Region: Cupin_2; cl17218 698761004106 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698761004107 homopentamer interface [polypeptide binding]; other site 698761004108 active site 698761004109 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698761004110 putative RNA binding site [nucleotide binding]; other site 698761004111 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 698761004112 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 698761004113 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 698761004114 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 698761004115 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 698761004116 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 698761004117 putative phosphate acyltransferase; Provisional; Region: PRK05331 698761004118 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 698761004119 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698761004120 dimer interface [polypeptide binding]; other site 698761004121 active site 698761004122 CoA binding pocket [chemical binding]; other site 698761004123 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698761004124 IHF dimer interface [polypeptide binding]; other site 698761004125 IHF - DNA interface [nucleotide binding]; other site 698761004126 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 698761004127 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698761004128 DNA binding residues [nucleotide binding] 698761004129 Porin subfamily; Region: Porin_2; pfam02530 698761004130 BA14K-like protein; Region: BA14K; pfam07886 698761004131 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698761004132 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 698761004133 Helix-turn-helix domain; Region: HTH_25; pfam13413 698761004134 non-specific DNA binding site [nucleotide binding]; other site 698761004135 salt bridge; other site 698761004136 sequence-specific DNA binding site [nucleotide binding]; other site 698761004137 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698761004138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761004139 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 698761004140 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 698761004141 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 698761004142 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698761004143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761004144 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698761004145 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 698761004146 SLBB domain; Region: SLBB; pfam10531 698761004147 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 698761004148 Chain length determinant protein; Region: Wzz; pfam02706 698761004149 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 698761004150 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 698761004151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 698761004152 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 698761004153 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698761004154 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 698761004155 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 698761004156 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 698761004157 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698761004158 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 698761004159 agmatinase; Region: agmatinase; TIGR01230 698761004160 oligomer interface [polypeptide binding]; other site 698761004161 putative active site [active] 698761004162 Mn binding site [ion binding]; other site 698761004163 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698761004164 Transposase IS200 like; Region: Y1_Tnp; pfam01797 698761004165 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698761004166 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698761004167 23S rRNA interface [nucleotide binding]; other site 698761004168 L3 interface [polypeptide binding]; other site 698761004169 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 698761004170 EamA-like transporter family; Region: EamA; cl17759 698761004171 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 698761004172 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 698761004173 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698761004174 homodimer interface [polypeptide binding]; other site 698761004175 substrate-cofactor binding pocket; other site 698761004176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761004177 catalytic residue [active] 698761004178 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 698761004179 PBP superfamily domain; Region: PBP_like_2; cl17296 698761004180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761004181 dimer interface [polypeptide binding]; other site 698761004182 conserved gate region; other site 698761004183 putative PBP binding loops; other site 698761004184 ABC-ATPase subunit interface; other site 698761004185 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 698761004186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761004187 dimer interface [polypeptide binding]; other site 698761004188 conserved gate region; other site 698761004189 putative PBP binding loops; other site 698761004190 ABC-ATPase subunit interface; other site 698761004191 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 698761004192 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698761004193 Walker A/P-loop; other site 698761004194 ATP binding site [chemical binding]; other site 698761004195 Q-loop/lid; other site 698761004196 ABC transporter signature motif; other site 698761004197 Walker B; other site 698761004198 D-loop; other site 698761004199 H-loop/switch region; other site 698761004200 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761004201 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761004202 metal binding site [ion binding]; metal-binding site 698761004203 active site 698761004204 I-site; other site 698761004205 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 698761004206 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698761004207 oligomer interface [polypeptide binding]; other site 698761004208 active site residues [active] 698761004209 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698761004210 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 698761004211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761004212 Walker A motif; other site 698761004213 ATP binding site [chemical binding]; other site 698761004214 Walker B motif; other site 698761004215 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698761004216 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 698761004217 Found in ATP-dependent protease La (LON); Region: LON; smart00464 698761004218 Found in ATP-dependent protease La (LON); Region: LON; smart00464 698761004219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761004220 Walker A motif; other site 698761004221 ATP binding site [chemical binding]; other site 698761004222 Walker B motif; other site 698761004223 arginine finger; other site 698761004224 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 698761004225 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698761004226 IHF dimer interface [polypeptide binding]; other site 698761004227 IHF - DNA interface [nucleotide binding]; other site 698761004228 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761004229 classical (c) SDRs; Region: SDR_c; cd05233 698761004230 NAD(P) binding site [chemical binding]; other site 698761004231 active site 698761004232 DoxX-like family; Region: DoxX_2; pfam13564 698761004233 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761004234 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698761004235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761004236 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698761004237 NAD(P) binding site [chemical binding]; other site 698761004238 active site 698761004239 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761004240 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761004241 active site 698761004242 catalytic tetrad [active] 698761004243 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698761004244 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761004245 active site 698761004246 metal binding site [ion binding]; metal-binding site 698761004247 DNA binding site [nucleotide binding] 698761004248 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 698761004249 P-loop containing region of AAA domain; Region: AAA_29; cl17516 698761004250 AAA domain; Region: AAA_23; pfam13476 698761004251 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761004252 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761004253 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761004254 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698761004255 active site 698761004256 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698761004257 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 698761004258 Probable Catalytic site; other site 698761004259 metal-binding site 698761004260 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 698761004261 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698761004262 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698761004263 Walker A/P-loop; other site 698761004264 ATP binding site [chemical binding]; other site 698761004265 Q-loop/lid; other site 698761004266 ABC transporter signature motif; other site 698761004267 Walker B; other site 698761004268 D-loop; other site 698761004269 H-loop/switch region; other site 698761004270 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 698761004271 Chain length determinant protein; Region: Wzz; cl15801 698761004272 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761004273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761004274 S-adenosylmethionine binding site [chemical binding]; other site 698761004275 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698761004276 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698761004277 SLBB domain; Region: SLBB; pfam10531 698761004278 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698761004279 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698761004280 active site 698761004281 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698761004282 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 698761004283 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 698761004284 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 698761004285 Enoylreductase; Region: PKS_ER; smart00829 698761004286 NAD(P) binding site [chemical binding]; other site 698761004287 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 698761004288 KR domain; Region: KR; pfam08659 698761004289 NADP binding site [chemical binding]; other site 698761004290 active site 698761004291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698761004292 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 698761004293 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 698761004294 substrate-cofactor binding pocket; other site 698761004295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761004296 catalytic residue [active] 698761004297 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698761004298 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 698761004299 putative NAD(P) binding site [chemical binding]; other site 698761004300 homotetramer interface [polypeptide binding]; other site 698761004301 active site 698761004302 homodimer interface [polypeptide binding]; other site 698761004303 Sulfatase; Region: Sulfatase; cl17466 698761004304 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 698761004305 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 698761004306 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 698761004307 NADH dehydrogenase subunit B; Validated; Region: PRK06411 698761004308 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 698761004309 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 698761004310 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 698761004311 NADH dehydrogenase subunit D; Validated; Region: PRK06075 698761004312 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 698761004313 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 698761004314 putative dimer interface [polypeptide binding]; other site 698761004315 [2Fe-2S] cluster binding site [ion binding]; other site 698761004316 Uncharacterized conserved protein [Function unknown]; Region: COG3743 698761004317 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 698761004318 SLBB domain; Region: SLBB; pfam10531 698761004319 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 698761004320 Uncharacterized conserved protein [Function unknown]; Region: COG3743 698761004321 NADH dehydrogenase subunit G; Validated; Region: PRK09130 698761004322 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761004323 catalytic loop [active] 698761004324 iron binding site [ion binding]; other site 698761004325 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 698761004326 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 698761004327 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 698761004328 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 698761004329 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 698761004330 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 698761004331 4Fe-4S binding domain; Region: Fer4; pfam00037 698761004332 4Fe-4S binding domain; Region: Fer4; pfam00037 698761004333 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 698761004334 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 698761004335 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 698761004336 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 698761004337 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698761004338 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698761004339 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 698761004340 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 698761004341 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698761004342 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 698761004343 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698761004344 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698761004345 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 698761004346 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 698761004347 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698761004348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698761004349 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698761004350 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761004351 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698761004352 dimer interface [polypeptide binding]; other site 698761004353 substrate binding site [chemical binding]; other site 698761004354 metal binding site [ion binding]; metal-binding site 698761004355 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698761004356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698761004357 Homeodomain-like domain; Region: HTH_23; pfam13384 698761004358 Winged helix-turn helix; Region: HTH_29; pfam13551 698761004359 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 698761004360 prolyl-tRNA synthetase; Provisional; Region: PRK12325 698761004361 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698761004362 dimer interface [polypeptide binding]; other site 698761004363 motif 1; other site 698761004364 active site 698761004365 motif 2; other site 698761004366 motif 3; other site 698761004367 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698761004368 anticodon binding site; other site 698761004369 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 698761004370 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698761004371 FtsX-like permease family; Region: FtsX; pfam02687 698761004372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761004373 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698761004374 Walker A/P-loop; other site 698761004375 ATP binding site [chemical binding]; other site 698761004376 Q-loop/lid; other site 698761004377 ABC transporter signature motif; other site 698761004378 Walker B; other site 698761004379 D-loop; other site 698761004380 H-loop/switch region; other site 698761004381 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 698761004382 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698761004383 putative active site [active] 698761004384 putative PHP Thumb interface [polypeptide binding]; other site 698761004385 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698761004386 generic binding surface II; other site 698761004387 generic binding surface I; other site 698761004388 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761004389 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 698761004390 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761004391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761004392 Transposase; Region: HTH_Tnp_1; pfam01527 698761004393 putative transposase OrfB; Reviewed; Region: PHA02517 698761004394 HTH-like domain; Region: HTH_21; pfam13276 698761004395 Integrase core domain; Region: rve; pfam00665 698761004396 Integrase core domain; Region: rve_2; pfam13333 698761004397 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 698761004398 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698761004399 active site 698761004400 DNA polymerase IV; Provisional; Region: PRK02794 698761004401 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698761004402 active site 698761004403 DNA binding site [nucleotide binding] 698761004404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761004405 Coenzyme A binding pocket [chemical binding]; other site 698761004406 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 698761004407 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698761004408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761004409 active site 698761004410 phosphorylation site [posttranslational modification] 698761004411 intermolecular recognition site; other site 698761004412 dimerization interface [polypeptide binding]; other site 698761004413 response regulator PleD; Reviewed; Region: pleD; PRK09581 698761004414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761004415 active site 698761004416 phosphorylation site [posttranslational modification] 698761004417 intermolecular recognition site; other site 698761004418 dimerization interface [polypeptide binding]; other site 698761004419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761004420 active site 698761004421 phosphorylation site [posttranslational modification] 698761004422 intermolecular recognition site; other site 698761004423 dimerization interface [polypeptide binding]; other site 698761004424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761004425 metal binding site [ion binding]; metal-binding site 698761004426 active site 698761004427 I-site; other site 698761004428 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698761004429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761004430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761004431 putative substrate translocation pore; other site 698761004432 Protein of unknown function (DUF983); Region: DUF983; cl02211 698761004433 ribonuclease R; Region: RNase_R; TIGR02063 698761004434 RNB domain; Region: RNB; pfam00773 698761004435 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 698761004436 RNA binding site [nucleotide binding]; other site 698761004437 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 698761004438 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698761004439 active site 698761004440 interdomain interaction site; other site 698761004441 putative metal-binding site [ion binding]; other site 698761004442 nucleotide binding site [chemical binding]; other site 698761004443 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698761004444 domain I; other site 698761004445 DNA binding groove [nucleotide binding] 698761004446 phosphate binding site [ion binding]; other site 698761004447 domain II; other site 698761004448 domain III; other site 698761004449 nucleotide binding site [chemical binding]; other site 698761004450 catalytic site [active] 698761004451 domain IV; other site 698761004452 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 698761004453 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698761004454 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698761004455 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698761004456 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 698761004457 DNA protecting protein DprA; Region: dprA; TIGR00732 698761004458 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 698761004459 dihydroorotase; Validated; Region: PRK09059 698761004460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761004461 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698761004462 active site 698761004463 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698761004464 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698761004465 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698761004466 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761004467 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761004468 active site 698761004469 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 698761004470 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698761004471 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 698761004472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761004473 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698761004474 metal-dependent hydrolase; Provisional; Region: PRK00685 698761004475 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698761004476 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698761004477 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698761004478 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698761004479 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 698761004480 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 698761004481 hypothetical protein; Provisional; Region: PRK13687 698761004482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761004483 Coenzyme A binding pocket [chemical binding]; other site 698761004484 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698761004485 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698761004486 GatB domain; Region: GatB_Yqey; smart00845 698761004487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761004488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761004489 Coenzyme A binding pocket [chemical binding]; other site 698761004490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761004491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761004492 Coenzyme A binding pocket [chemical binding]; other site 698761004493 NADH dehydrogenase; Validated; Region: PRK08183 698761004494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 698761004495 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 698761004496 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 698761004497 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 698761004498 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698761004499 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698761004500 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698761004501 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 698761004502 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698761004503 carboxyltransferase (CT) interaction site; other site 698761004504 biotinylation site [posttranslational modification]; other site 698761004505 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698761004506 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698761004507 trimer interface [polypeptide binding]; other site 698761004508 active site 698761004509 dimer interface [polypeptide binding]; other site 698761004510 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698761004511 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 698761004512 catalytic residues [active] 698761004513 aspartate aminotransferase; Provisional; Region: PRK05764 698761004514 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761004515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761004516 homodimer interface [polypeptide binding]; other site 698761004517 catalytic residue [active] 698761004518 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698761004519 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698761004520 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 698761004521 AMIN domain; Region: AMIN; pfam11741 698761004522 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698761004523 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698761004524 active site 698761004525 metal binding site [ion binding]; metal-binding site 698761004526 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 698761004527 Transglycosylase; Region: Transgly; pfam00912 698761004528 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698761004529 peptide chain release factor 2; Provisional; Region: PRK07342 698761004530 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698761004531 RF-1 domain; Region: RF-1; pfam00472 698761004532 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 698761004533 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698761004534 Protease inhibitor Inh; Region: Inh; pfam02974 698761004535 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698761004536 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 698761004537 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698761004538 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 698761004539 elongation factor Tu; Reviewed; Region: PRK00049 698761004540 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698761004541 G1 box; other site 698761004542 GEF interaction site [polypeptide binding]; other site 698761004543 GTP/Mg2+ binding site [chemical binding]; other site 698761004544 Switch I region; other site 698761004545 G2 box; other site 698761004546 G3 box; other site 698761004547 Switch II region; other site 698761004548 G4 box; other site 698761004549 G5 box; other site 698761004550 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698761004551 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698761004552 Antibiotic Binding Site [chemical binding]; other site 698761004553 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 698761004554 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761004555 extended (e) SDRs; Region: SDR_e; cd08946 698761004556 NAD(P) binding site [chemical binding]; other site 698761004557 active site 698761004558 substrate binding site [chemical binding]; other site 698761004559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698761004560 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 698761004561 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698761004562 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698761004563 putative homodimer interface [polypeptide binding]; other site 698761004564 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698761004565 heterodimer interface [polypeptide binding]; other site 698761004566 homodimer interface [polypeptide binding]; other site 698761004567 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698761004568 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698761004569 23S rRNA interface [nucleotide binding]; other site 698761004570 L7/L12 interface [polypeptide binding]; other site 698761004571 putative thiostrepton binding site; other site 698761004572 L25 interface [polypeptide binding]; other site 698761004573 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698761004574 mRNA/rRNA interface [nucleotide binding]; other site 698761004575 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698761004576 23S rRNA interface [nucleotide binding]; other site 698761004577 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698761004578 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 698761004579 L11 interface [polypeptide binding]; other site 698761004580 putative EF-Tu interaction site [polypeptide binding]; other site 698761004581 putative EF-G interaction site [polypeptide binding]; other site 698761004582 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698761004583 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698761004584 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698761004585 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698761004586 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 698761004587 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698761004588 RPB1 interaction site [polypeptide binding]; other site 698761004589 RPB11 interaction site [polypeptide binding]; other site 698761004590 RPB10 interaction site [polypeptide binding]; other site 698761004591 RPB3 interaction site [polypeptide binding]; other site 698761004592 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698761004593 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 698761004594 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698761004595 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698761004596 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698761004597 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 698761004598 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 698761004599 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 698761004600 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698761004601 DNA binding site [nucleotide binding] 698761004602 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698761004603 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698761004604 S17 interaction site [polypeptide binding]; other site 698761004605 S8 interaction site; other site 698761004606 16S rRNA interaction site [nucleotide binding]; other site 698761004607 streptomycin interaction site [chemical binding]; other site 698761004608 23S rRNA interaction site [nucleotide binding]; other site 698761004609 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698761004610 30S ribosomal protein S7; Validated; Region: PRK05302 698761004611 elongation factor G; Reviewed; Region: PRK00007 698761004612 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698761004613 G1 box; other site 698761004614 putative GEF interaction site [polypeptide binding]; other site 698761004615 GTP/Mg2+ binding site [chemical binding]; other site 698761004616 Switch I region; other site 698761004617 G2 box; other site 698761004618 G3 box; other site 698761004619 Switch II region; other site 698761004620 G4 box; other site 698761004621 G5 box; other site 698761004622 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698761004623 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698761004624 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698761004625 elongation factor Tu; Reviewed; Region: PRK00049 698761004626 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698761004627 G1 box; other site 698761004628 GEF interaction site [polypeptide binding]; other site 698761004629 GTP/Mg2+ binding site [chemical binding]; other site 698761004630 Switch I region; other site 698761004631 G2 box; other site 698761004632 G3 box; other site 698761004633 Switch II region; other site 698761004634 G4 box; other site 698761004635 G5 box; other site 698761004636 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698761004637 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698761004638 Antibiotic Binding Site [chemical binding]; other site 698761004639 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698761004640 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698761004641 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698761004642 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698761004643 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698761004644 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698761004645 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698761004646 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698761004647 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698761004648 putative translocon binding site; other site 698761004649 protein-rRNA interface [nucleotide binding]; other site 698761004650 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698761004651 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698761004652 G-X-X-G motif; other site 698761004653 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698761004654 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698761004655 23S rRNA interface [nucleotide binding]; other site 698761004656 5S rRNA interface [nucleotide binding]; other site 698761004657 putative antibiotic binding site [chemical binding]; other site 698761004658 L25 interface [polypeptide binding]; other site 698761004659 L27 interface [polypeptide binding]; other site 698761004660 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698761004661 23S rRNA interface [nucleotide binding]; other site 698761004662 putative translocon interaction site; other site 698761004663 signal recognition particle (SRP54) interaction site; other site 698761004664 L23 interface [polypeptide binding]; other site 698761004665 trigger factor interaction site; other site 698761004666 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698761004667 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698761004668 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698761004669 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698761004670 RNA binding site [nucleotide binding]; other site 698761004671 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698761004672 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698761004673 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698761004674 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698761004675 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698761004676 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698761004677 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698761004678 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698761004679 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698761004680 23S rRNA interface [nucleotide binding]; other site 698761004681 L21e interface [polypeptide binding]; other site 698761004682 5S rRNA interface [nucleotide binding]; other site 698761004683 L27 interface [polypeptide binding]; other site 698761004684 L5 interface [polypeptide binding]; other site 698761004685 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698761004686 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698761004687 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698761004688 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698761004689 23S rRNA binding site [nucleotide binding]; other site 698761004690 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698761004691 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698761004692 SecY translocase; Region: SecY; pfam00344 698761004693 adenylate kinase; Reviewed; Region: adk; PRK00279 698761004694 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698761004695 AMP-binding site [chemical binding]; other site 698761004696 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698761004697 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698761004698 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698761004699 30S ribosomal protein S11; Validated; Region: PRK05309 698761004700 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698761004701 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698761004702 alphaNTD homodimer interface [polypeptide binding]; other site 698761004703 alphaNTD - beta interaction site [polypeptide binding]; other site 698761004704 alphaNTD - beta' interaction site [polypeptide binding]; other site 698761004705 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698761004706 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698761004707 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 698761004708 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761004709 MarR family; Region: MarR_2; cl17246 698761004710 Fusaric acid resistance protein family; Region: FUSC; pfam04632 698761004711 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698761004712 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 698761004713 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 698761004714 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761004715 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761004716 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 698761004717 TMAO/DMSO reductase; Reviewed; Region: PRK05363 698761004718 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 698761004719 Moco binding site; other site 698761004720 metal coordination site [ion binding]; other site 698761004721 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 698761004722 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 698761004723 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 698761004724 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698761004725 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761004726 protein binding site [polypeptide binding]; other site 698761004727 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761004728 protein binding site [polypeptide binding]; other site 698761004729 recombination factor protein RarA; Reviewed; Region: PRK13342 698761004730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761004731 Walker A motif; other site 698761004732 ATP binding site [chemical binding]; other site 698761004733 Walker B motif; other site 698761004734 arginine finger; other site 698761004735 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698761004736 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 698761004737 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698761004738 dihydrodipicolinate synthase; Region: dapA; TIGR00674 698761004739 dimer interface [polypeptide binding]; other site 698761004740 active site 698761004741 catalytic residue [active] 698761004742 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 698761004743 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698761004744 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698761004745 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 698761004746 ligand binding site [chemical binding]; other site 698761004747 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698761004748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761004749 Walker A/P-loop; other site 698761004750 ATP binding site [chemical binding]; other site 698761004751 Q-loop/lid; other site 698761004752 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761004753 ABC transporter signature motif; other site 698761004754 Walker B; other site 698761004755 D-loop; other site 698761004756 ABC transporter; Region: ABC_tran_2; pfam12848 698761004757 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761004758 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761004759 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 698761004760 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 698761004761 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698761004762 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 698761004763 active site 698761004764 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698761004765 TSCPD domain; Region: TSCPD; pfam12637 698761004766 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761004767 active site 698761004768 Universal stress protein family; Region: Usp; pfam00582 698761004769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698761004770 Ligand Binding Site [chemical binding]; other site 698761004771 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 698761004772 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 698761004773 putative MPT binding site; other site 698761004774 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 698761004775 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761004776 threonine dehydratase; Validated; Region: PRK08639 698761004777 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698761004778 tetramer interface [polypeptide binding]; other site 698761004779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761004780 catalytic residue [active] 698761004781 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698761004782 Transcriptional activator HlyU; Region: HlyU; pfam10115 698761004783 short chain dehydrogenase; Provisional; Region: PRK06500 698761004784 classical (c) SDRs; Region: SDR_c; cd05233 698761004785 NAD(P) binding site [chemical binding]; other site 698761004786 active site 698761004787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761004788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761004789 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 698761004790 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761004791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761004792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761004793 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698761004794 dimerization interface [polypeptide binding]; other site 698761004795 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 698761004796 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 698761004797 active site 698761004798 metal binding site [ion binding]; metal-binding site 698761004799 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698761004800 PilZ domain; Region: PilZ; pfam07238 698761004801 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698761004802 putative catalytic site [active] 698761004803 putative metal binding site [ion binding]; other site 698761004804 putative phosphate binding site [ion binding]; other site 698761004805 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761004806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761004807 putative DNA binding site [nucleotide binding]; other site 698761004808 putative Zn2+ binding site [ion binding]; other site 698761004809 AsnC family; Region: AsnC_trans_reg; pfam01037 698761004810 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 698761004811 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 698761004812 hexamer interface [polypeptide binding]; other site 698761004813 ligand binding site [chemical binding]; other site 698761004814 putative active site [active] 698761004815 NAD(P) binding site [chemical binding]; other site 698761004816 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 698761004817 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698761004818 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698761004819 active site residue [active] 698761004820 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698761004821 active site residue [active] 698761004822 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 698761004823 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698761004824 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698761004825 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698761004826 dimer interface [polypeptide binding]; other site 698761004827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761004828 catalytic residue [active] 698761004829 short chain dehydrogenase; Provisional; Region: PRK07024 698761004830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761004831 NAD(P) binding site [chemical binding]; other site 698761004832 active site 698761004833 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698761004834 DNA photolyase; Region: DNA_photolyase; pfam00875 698761004835 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761004836 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761004837 Walker A/P-loop; other site 698761004838 ATP binding site [chemical binding]; other site 698761004839 Q-loop/lid; other site 698761004840 ABC transporter signature motif; other site 698761004841 Walker B; other site 698761004842 D-loop; other site 698761004843 H-loop/switch region; other site 698761004844 TOBE domain; Region: TOBE_2; pfam08402 698761004845 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761004846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761004847 dimer interface [polypeptide binding]; other site 698761004848 conserved gate region; other site 698761004849 putative PBP binding loops; other site 698761004850 ABC-ATPase subunit interface; other site 698761004851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698761004852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761004853 putative PBP binding loops; other site 698761004854 ABC-ATPase subunit interface; other site 698761004855 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761004856 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761004857 maltose O-acetyltransferase; Provisional; Region: PRK10092 698761004858 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698761004859 active site 698761004860 substrate binding site [chemical binding]; other site 698761004861 trimer interface [polypeptide binding]; other site 698761004862 CoA binding site [chemical binding]; other site 698761004863 Porin subfamily; Region: Porin_2; pfam02530 698761004864 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 698761004865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761004866 S-adenosylmethionine binding site [chemical binding]; other site 698761004867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 698761004868 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698761004869 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698761004870 HIGH motif; other site 698761004871 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698761004872 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698761004873 active site 698761004874 KMSKS motif; other site 698761004875 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698761004876 tRNA binding surface [nucleotide binding]; other site 698761004877 anticodon binding site; other site 698761004878 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698761004879 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 698761004880 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698761004881 Sel1-like repeats; Region: SEL1; smart00671 698761004882 Sel1-like repeats; Region: SEL1; smart00671 698761004883 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 698761004884 putative catalytic site [active] 698761004885 putative phosphate binding site [ion binding]; other site 698761004886 active site 698761004887 metal binding site A [ion binding]; metal-binding site 698761004888 DNA binding site [nucleotide binding] 698761004889 putative AP binding site [nucleotide binding]; other site 698761004890 putative metal binding site B [ion binding]; other site 698761004891 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698761004892 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 698761004893 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698761004894 Zn2+ binding site [ion binding]; other site 698761004895 Mg2+ binding site [ion binding]; other site 698761004896 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698761004897 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 698761004898 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 698761004899 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698761004900 active site 698761004901 HIGH motif; other site 698761004902 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698761004903 KMSK motif region; other site 698761004904 tRNA binding surface [nucleotide binding]; other site 698761004905 DALR anticodon binding domain; Region: DALR_1; smart00836 698761004906 anticodon binding site; other site 698761004907 Sporulation related domain; Region: SPOR; pfam05036 698761004908 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698761004909 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698761004910 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 698761004911 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 698761004912 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 698761004913 sec-independent translocase; Provisional; Region: PRK00708 698761004914 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 698761004915 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698761004916 seryl-tRNA synthetase; Provisional; Region: PRK05431 698761004917 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698761004918 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698761004919 dimer interface [polypeptide binding]; other site 698761004920 active site 698761004921 motif 1; other site 698761004922 motif 2; other site 698761004923 motif 3; other site 698761004924 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 698761004925 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 698761004926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761004927 S-adenosylmethionine binding site [chemical binding]; other site 698761004928 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698761004929 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698761004930 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698761004931 Peptidase family M23; Region: Peptidase_M23; pfam01551 698761004932 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 698761004933 Protein of unknown function (DUF815); Region: DUF815; pfam05673 698761004934 Walker A motif; other site 698761004935 ATP binding site [chemical binding]; other site 698761004936 Walker B motif; other site 698761004937 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 698761004938 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 698761004939 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 698761004940 Protein export membrane protein; Region: SecD_SecF; cl14618 698761004941 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 698761004942 Protein export membrane protein; Region: SecD_SecF; pfam02355 698761004943 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 698761004944 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 698761004945 substrate binding pocket [chemical binding]; other site 698761004946 substrate-Mg2+ binding site; other site 698761004947 aspartate-rich region 1; other site 698761004948 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 698761004949 Glucose inhibited division protein A; Region: GIDA; pfam01134 698761004950 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698761004951 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698761004952 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 698761004953 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 698761004954 trigger factor; Provisional; Region: tig; PRK01490 698761004955 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698761004956 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698761004957 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 698761004958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761004959 motif I; other site 698761004960 motif II; other site 698761004961 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 698761004962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761004963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761004964 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698761004965 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 698761004966 hypothetical protein; Reviewed; Region: PRK00024 698761004967 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 698761004968 MPN+ (JAMM) motif; other site 698761004969 Zinc-binding site [ion binding]; other site 698761004970 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698761004971 active site 698761004972 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 698761004973 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 698761004974 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 698761004975 aminotransferase; Validated; Region: PRK09148 698761004976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761004977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761004978 homodimer interface [polypeptide binding]; other site 698761004979 catalytic residue [active] 698761004980 homoserine dehydrogenase; Provisional; Region: PRK06349 698761004981 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698761004982 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698761004983 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698761004984 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 698761004985 DHH family; Region: DHH; pfam01368 698761004986 DHHA1 domain; Region: DHHA1; pfam02272 698761004987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761004988 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 698761004989 dimer interface [polypeptide binding]; other site 698761004990 active site 698761004991 metal binding site [ion binding]; metal-binding site 698761004992 glutathione binding site [chemical binding]; other site 698761004993 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698761004994 DNA-binding site [nucleotide binding]; DNA binding site 698761004995 RNA-binding motif; other site 698761004996 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698761004997 DNA-binding site [nucleotide binding]; DNA binding site 698761004998 RNA-binding motif; other site 698761004999 integrase; Provisional; Region: PRK09692 698761005000 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 698761005001 active site 698761005002 Int/Topo IB signature motif; other site 698761005003 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761005004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761005005 non-specific DNA binding site [nucleotide binding]; other site 698761005006 sequence-specific DNA binding site [nucleotide binding]; other site 698761005007 salt bridge; other site 698761005008 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 698761005009 AAA domain; Region: AAA_25; pfam13481 698761005010 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698761005011 Walker A motif; other site 698761005012 ATP binding site [chemical binding]; other site 698761005013 Walker B motif; other site 698761005014 Phage Terminase; Region: Terminase_1; pfam03354 698761005015 Phage-related protein [Function unknown]; Region: COG4695; cl01923 698761005016 Phage portal protein; Region: Phage_portal; pfam04860 698761005017 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 698761005018 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 698761005019 Phage capsid family; Region: Phage_capsid; pfam05065 698761005020 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 698761005021 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 698761005022 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 698761005023 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 698761005024 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 698761005025 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 698761005026 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 698761005027 tape measure domain; Region: tape_meas_nterm; TIGR02675 698761005028 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 698761005029 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 698761005030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761005031 Walker A/P-loop; other site 698761005032 ATP binding site [chemical binding]; other site 698761005033 AAA domain; Region: AAA_21; pfam13304 698761005034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761005035 ABC transporter signature motif; other site 698761005036 Walker B; other site 698761005037 D-loop; other site 698761005038 H-loop/switch region; other site 698761005039 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698761005040 catalytic residue [active] 698761005041 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 698761005042 PLD-like domain; Region: PLDc_2; pfam13091 698761005043 putative active site [active] 698761005044 catalytic site [active] 698761005045 Helix-turn-helix domain; Region: HTH_17; pfam12728 698761005046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 698761005047 sequence-specific DNA binding site [nucleotide binding]; other site 698761005048 salt bridge; other site 698761005049 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698761005050 active site 698761005051 Divergent AAA domain; Region: AAA_4; pfam04326 698761005052 Uncharacterized conserved protein [Function unknown]; Region: COG1430 698761005053 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 698761005054 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761005055 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761005056 Walker A/P-loop; other site 698761005057 ATP binding site [chemical binding]; other site 698761005058 Q-loop/lid; other site 698761005059 ABC transporter signature motif; other site 698761005060 Walker B; other site 698761005061 D-loop; other site 698761005062 H-loop/switch region; other site 698761005063 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761005064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761005065 dimer interface [polypeptide binding]; other site 698761005066 conserved gate region; other site 698761005067 putative PBP binding loops; other site 698761005068 ABC-ATPase subunit interface; other site 698761005069 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 698761005070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761005071 conserved gate region; other site 698761005072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761005073 dimer interface [polypeptide binding]; other site 698761005074 ABC-ATPase subunit interface; other site 698761005075 putative PBP binding loops; other site 698761005076 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698761005077 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761005078 substrate binding pocket [chemical binding]; other site 698761005079 membrane-bound complex binding site; other site 698761005080 hinge residues; other site 698761005081 cystathionine beta-lyase; Provisional; Region: PRK05967 698761005082 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698761005083 homodimer interface [polypeptide binding]; other site 698761005084 substrate-cofactor binding pocket; other site 698761005085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761005086 catalytic residue [active] 698761005087 salicylate hydroxylase; Provisional; Region: PRK08163 698761005088 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761005089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 698761005090 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761005091 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761005092 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 698761005093 enoyl-CoA hydratase; Provisional; Region: PRK06127 698761005094 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761005095 substrate binding site [chemical binding]; other site 698761005096 oxyanion hole (OAH) forming residues; other site 698761005097 trimer interface [polypeptide binding]; other site 698761005098 serine acetyltransferase; Provisional; Region: cysE; PRK11132 698761005099 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 698761005100 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698761005101 trimer interface [polypeptide binding]; other site 698761005102 active site 698761005103 substrate binding site [chemical binding]; other site 698761005104 CoA binding site [chemical binding]; other site 698761005105 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 698761005106 Phasin protein; Region: Phasin_2; pfam09361 698761005107 Uncharacterized conserved protein [Function unknown]; Region: COG2127 698761005108 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 698761005109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761005110 Walker A motif; other site 698761005111 ATP binding site [chemical binding]; other site 698761005112 Walker B motif; other site 698761005113 arginine finger; other site 698761005114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761005115 Walker A motif; other site 698761005116 ATP binding site [chemical binding]; other site 698761005117 Walker B motif; other site 698761005118 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698761005119 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 698761005120 HIT family signature motif; other site 698761005121 catalytic residue [active] 698761005122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 698761005123 Protein of unknown function, DUF482; Region: DUF482; pfam04339 698761005124 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 698761005125 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698761005126 putative active site [active] 698761005127 catalytic site [active] 698761005128 putative metal binding site [ion binding]; other site 698761005129 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698761005130 homotrimer interaction site [polypeptide binding]; other site 698761005131 putative active site [active] 698761005132 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 698761005133 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698761005134 rRNA interaction site [nucleotide binding]; other site 698761005135 S8 interaction site; other site 698761005136 putative laminin-1 binding site; other site 698761005137 elongation factor Ts; Provisional; Region: tsf; PRK09377 698761005138 UBA/TS-N domain; Region: UBA; pfam00627 698761005139 Elongation factor TS; Region: EF_TS; pfam00889 698761005140 Elongation factor TS; Region: EF_TS; pfam00889 698761005141 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698761005142 putative nucleotide binding site [chemical binding]; other site 698761005143 uridine monophosphate binding site [chemical binding]; other site 698761005144 homohexameric interface [polypeptide binding]; other site 698761005145 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698761005146 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698761005147 hinge region; other site 698761005148 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 698761005149 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698761005150 catalytic residue [active] 698761005151 putative FPP diphosphate binding site; other site 698761005152 putative FPP binding hydrophobic cleft; other site 698761005153 dimer interface [polypeptide binding]; other site 698761005154 putative IPP diphosphate binding site; other site 698761005155 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698761005156 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698761005157 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698761005158 active site 698761005159 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698761005160 protein binding site [polypeptide binding]; other site 698761005161 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698761005162 protein binding site [polypeptide binding]; other site 698761005163 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698761005164 protein binding site [polypeptide binding]; other site 698761005165 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698761005166 putative substrate binding region [chemical binding]; other site 698761005167 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 698761005168 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698761005169 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698761005170 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698761005171 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698761005172 Surface antigen; Region: Bac_surface_Ag; pfam01103 698761005173 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 698761005174 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 698761005175 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 698761005176 trimer interface [polypeptide binding]; other site 698761005177 active site 698761005178 UDP-GlcNAc binding site [chemical binding]; other site 698761005179 lipid binding site [chemical binding]; lipid-binding site 698761005180 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 698761005181 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 698761005182 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 698761005183 active site 698761005184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 698761005185 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 698761005186 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 698761005187 Transposase IS200 like; Region: Y1_Tnp; pfam01797 698761005188 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698761005189 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698761005190 dimer interface [polypeptide binding]; other site 698761005191 active site 698761005192 citrylCoA binding site [chemical binding]; other site 698761005193 NADH binding [chemical binding]; other site 698761005194 cationic pore residues; other site 698761005195 oxalacetate/citrate binding site [chemical binding]; other site 698761005196 coenzyme A binding site [chemical binding]; other site 698761005197 catalytic triad [active] 698761005198 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 698761005199 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 698761005200 Competence protein; Region: Competence; pfam03772 698761005201 LexA repressor; Validated; Region: PRK00215 698761005202 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 698761005203 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698761005204 Catalytic site [active] 698761005205 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 698761005206 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 698761005207 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 698761005208 enolase; Provisional; Region: eno; PRK00077 698761005209 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698761005210 dimer interface [polypeptide binding]; other site 698761005211 metal binding site [ion binding]; metal-binding site 698761005212 substrate binding pocket [chemical binding]; other site 698761005213 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698761005214 Septum formation initiator; Region: DivIC; pfam04977 698761005215 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 698761005216 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698761005217 tetramer interface [polypeptide binding]; other site 698761005218 TPP-binding site [chemical binding]; other site 698761005219 heterodimer interface [polypeptide binding]; other site 698761005220 phosphorylation loop region [posttranslational modification] 698761005221 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 698761005222 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698761005223 E3 interaction surface; other site 698761005224 lipoyl attachment site [posttranslational modification]; other site 698761005225 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698761005226 alpha subunit interface [polypeptide binding]; other site 698761005227 TPP binding site [chemical binding]; other site 698761005228 heterodimer interface [polypeptide binding]; other site 698761005229 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698761005230 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698761005231 E3 interaction surface; other site 698761005232 lipoyl attachment site [posttranslational modification]; other site 698761005233 e3 binding domain; Region: E3_binding; pfam02817 698761005234 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 698761005235 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698761005236 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 698761005237 active site 698761005238 catalytic triad [active] 698761005239 oxyanion hole [active] 698761005240 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 698761005241 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698761005242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761005243 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698761005244 lipoyl synthase; Provisional; Region: PRK05481 698761005245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761005246 FeS/SAM binding site; other site 698761005247 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698761005248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761005249 active site 698761005250 topology modulation protein; Reviewed; Region: PRK08118 698761005251 AAA domain; Region: AAA_17; pfam13207 698761005252 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 698761005253 putative coenzyme Q binding site [chemical binding]; other site 698761005254 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 698761005255 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 698761005256 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698761005257 substrate binding site; other site 698761005258 dimer interface; other site 698761005259 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698761005260 homotrimer interaction site [polypeptide binding]; other site 698761005261 zinc binding site [ion binding]; other site 698761005262 CDP-binding sites; other site 698761005263 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698761005264 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 698761005265 FMN binding site [chemical binding]; other site 698761005266 active site 698761005267 catalytic residues [active] 698761005268 substrate binding site [chemical binding]; other site 698761005269 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 698761005270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761005271 dimer interface [polypeptide binding]; other site 698761005272 phosphorylation site [posttranslational modification] 698761005273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761005274 ATP binding site [chemical binding]; other site 698761005275 Mg2+ binding site [ion binding]; other site 698761005276 G-X-G motif; other site 698761005277 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 698761005278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761005279 active site 698761005280 phosphorylation site [posttranslational modification] 698761005281 intermolecular recognition site; other site 698761005282 dimerization interface [polypeptide binding]; other site 698761005283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761005284 Walker A motif; other site 698761005285 ATP binding site [chemical binding]; other site 698761005286 Walker B motif; other site 698761005287 arginine finger; other site 698761005288 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 698761005289 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 698761005290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761005291 dimerization interface [polypeptide binding]; other site 698761005292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761005293 putative active site [active] 698761005294 heme pocket [chemical binding]; other site 698761005295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761005296 dimer interface [polypeptide binding]; other site 698761005297 phosphorylation site [posttranslational modification] 698761005298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761005299 ATP binding site [chemical binding]; other site 698761005300 Mg2+ binding site [ion binding]; other site 698761005301 G-X-G motif; other site 698761005302 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 698761005303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761005304 active site 698761005305 phosphorylation site [posttranslational modification] 698761005306 intermolecular recognition site; other site 698761005307 dimerization interface [polypeptide binding]; other site 698761005308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761005309 Walker A motif; other site 698761005310 ATP binding site [chemical binding]; other site 698761005311 Walker B motif; other site 698761005312 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698761005313 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698761005314 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 698761005315 homodimer interface [polypeptide binding]; other site 698761005316 substrate-cofactor binding pocket; other site 698761005317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761005318 catalytic residue [active] 698761005319 bacterial Hfq-like; Region: Hfq; cd01716 698761005320 hexamer interface [polypeptide binding]; other site 698761005321 Sm1 motif; other site 698761005322 RNA binding site [nucleotide binding]; other site 698761005323 Sm2 motif; other site 698761005324 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 698761005325 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698761005326 HflX GTPase family; Region: HflX; cd01878 698761005327 G1 box; other site 698761005328 GTP/Mg2+ binding site [chemical binding]; other site 698761005329 Switch I region; other site 698761005330 G2 box; other site 698761005331 G3 box; other site 698761005332 Switch II region; other site 698761005333 G4 box; other site 698761005334 G5 box; other site 698761005335 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 698761005336 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698761005337 homodimer interface [polypeptide binding]; other site 698761005338 metal binding site [ion binding]; metal-binding site 698761005339 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 698761005340 homodimer interface [polypeptide binding]; other site 698761005341 active site 698761005342 putative chemical substrate binding site [chemical binding]; other site 698761005343 metal binding site [ion binding]; metal-binding site 698761005344 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698761005345 nucleoside/Zn binding site; other site 698761005346 dimer interface [polypeptide binding]; other site 698761005347 catalytic motif [active] 698761005348 siroheme synthase; Provisional; Region: cysG; PRK10637 698761005349 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 698761005350 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 698761005351 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698761005352 active site 698761005353 SAM binding site [chemical binding]; other site 698761005354 homodimer interface [polypeptide binding]; other site 698761005355 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 698761005356 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 698761005357 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698761005358 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698761005359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 698761005360 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698761005361 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 698761005362 FAD binding pocket [chemical binding]; other site 698761005363 FAD binding motif [chemical binding]; other site 698761005364 phosphate binding motif [ion binding]; other site 698761005365 beta-alpha-beta structure motif; other site 698761005366 NAD binding pocket [chemical binding]; other site 698761005367 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 698761005368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761005369 DNA-binding site [nucleotide binding]; DNA binding site 698761005370 FCD domain; Region: FCD; pfam07729 698761005371 Predicted membrane protein [Function unknown]; Region: COG2261 698761005372 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698761005373 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 698761005374 Predicted permeases [General function prediction only]; Region: COG0679 698761005375 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 698761005376 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761005377 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 698761005378 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 698761005379 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 698761005380 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 698761005381 NADP binding site [chemical binding]; other site 698761005382 dimer interface [polypeptide binding]; other site 698761005383 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698761005384 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761005385 Walker A/P-loop; other site 698761005386 ATP binding site [chemical binding]; other site 698761005387 Q-loop/lid; other site 698761005388 ABC transporter signature motif; other site 698761005389 Walker B; other site 698761005390 D-loop; other site 698761005391 H-loop/switch region; other site 698761005392 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761005393 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761005394 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761005395 TM-ABC transporter signature motif; other site 698761005396 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761005397 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761005398 TM-ABC transporter signature motif; other site 698761005399 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698761005400 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 698761005401 putative ligand binding site [chemical binding]; other site 698761005402 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761005403 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 698761005404 putative ligand binding site [chemical binding]; other site 698761005405 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761005406 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761005407 Walker A/P-loop; other site 698761005408 ATP binding site [chemical binding]; other site 698761005409 Q-loop/lid; other site 698761005410 ABC transporter signature motif; other site 698761005411 Walker B; other site 698761005412 D-loop; other site 698761005413 H-loop/switch region; other site 698761005414 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761005415 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761005416 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761005417 TM-ABC transporter signature motif; other site 698761005418 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761005419 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761005420 TM-ABC transporter signature motif; other site 698761005421 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761005422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761005423 DNA-binding site [nucleotide binding]; DNA binding site 698761005424 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698761005425 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 698761005426 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698761005427 Substrate binding site; other site 698761005428 Mg++ binding site; other site 698761005429 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698761005430 active site 698761005431 substrate binding site [chemical binding]; other site 698761005432 CoA binding site [chemical binding]; other site 698761005433 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698761005434 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698761005435 glutaminase active site [active] 698761005436 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698761005437 dimer interface [polypeptide binding]; other site 698761005438 active site 698761005439 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698761005440 dimer interface [polypeptide binding]; other site 698761005441 active site 698761005442 Uncharacterized conserved protein [Function unknown]; Region: COG2928 698761005443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 698761005444 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698761005445 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698761005446 generic binding surface II; other site 698761005447 ssDNA binding site; other site 698761005448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698761005449 ATP binding site [chemical binding]; other site 698761005450 putative Mg++ binding site [ion binding]; other site 698761005451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761005452 nucleotide binding region [chemical binding]; other site 698761005453 ATP-binding site [chemical binding]; other site 698761005454 Uncharacterized conserved protein [Function unknown]; Region: COG2938 698761005455 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698761005456 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 698761005457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698761005458 ATP binding site [chemical binding]; other site 698761005459 putative Mg++ binding site [ion binding]; other site 698761005460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761005461 nucleotide binding region [chemical binding]; other site 698761005462 ATP-binding site [chemical binding]; other site 698761005463 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 698761005464 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 698761005465 UbiA prenyltransferase family; Region: UbiA; pfam01040 698761005466 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 698761005467 homotrimer interaction site [polypeptide binding]; other site 698761005468 putative active site [active] 698761005469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761005470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761005471 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 698761005472 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 698761005473 catalytic residues [active] 698761005474 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698761005475 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 698761005476 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 698761005477 Uncharacterized conserved protein [Function unknown]; Region: COG3785 698761005478 glutamine synthetase; Provisional; Region: glnA; PRK09469 698761005479 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698761005480 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698761005481 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698761005482 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698761005483 Uncharacterized conserved protein [Function unknown]; Region: COG0062 698761005484 putative carbohydrate kinase; Provisional; Region: PRK10565 698761005485 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698761005486 putative substrate binding site [chemical binding]; other site 698761005487 putative ATP binding site [chemical binding]; other site 698761005488 Protein of unknown function DUF72; Region: DUF72; pfam01904 698761005489 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698761005490 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698761005491 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698761005492 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698761005493 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698761005494 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698761005495 dimer interface [polypeptide binding]; other site 698761005496 ssDNA binding site [nucleotide binding]; other site 698761005497 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698761005498 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761005499 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761005500 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761005501 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 698761005502 DNA gyrase subunit A; Validated; Region: PRK05560 698761005503 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698761005504 CAP-like domain; other site 698761005505 active site 698761005506 primary dimer interface [polypeptide binding]; other site 698761005507 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698761005508 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698761005509 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698761005510 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698761005511 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698761005512 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761005513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761005514 NAD(P) binding site [chemical binding]; other site 698761005515 active site 698761005516 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698761005517 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698761005518 active site 698761005519 (T/H)XGH motif; other site 698761005520 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698761005521 active site 698761005522 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698761005523 active site 698761005524 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 698761005525 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 698761005526 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 698761005527 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698761005528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761005529 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698761005530 active site 698761005531 metal binding site [ion binding]; metal-binding site 698761005532 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 698761005533 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 698761005534 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698761005535 dimer interface [polypeptide binding]; other site 698761005536 active site 698761005537 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761005538 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698761005539 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761005540 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761005541 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 698761005542 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761005543 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761005544 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761005545 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 698761005546 Walker A/P-loop; other site 698761005547 ATP binding site [chemical binding]; other site 698761005548 Q-loop/lid; other site 698761005549 ABC transporter signature motif; other site 698761005550 Walker B; other site 698761005551 D-loop; other site 698761005552 H-loop/switch region; other site 698761005553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761005554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761005555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761005556 Walker A/P-loop; other site 698761005557 ATP binding site [chemical binding]; other site 698761005558 Q-loop/lid; other site 698761005559 ABC transporter signature motif; other site 698761005560 Walker B; other site 698761005561 D-loop; other site 698761005562 H-loop/switch region; other site 698761005563 RibD C-terminal domain; Region: RibD_C; cl17279 698761005564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761005565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761005566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698761005567 dimerization interface [polypeptide binding]; other site 698761005568 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698761005569 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698761005570 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698761005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761005572 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761005573 S-adenosylmethionine binding site [chemical binding]; other site 698761005574 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 698761005575 putative hydrophobic ligand binding site [chemical binding]; other site 698761005576 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 698761005577 putative deacylase active site [active] 698761005578 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 698761005579 putative hydrolase; Provisional; Region: PRK02113 698761005580 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 698761005581 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698761005582 active site 698761005583 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 698761005584 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698761005585 active site 698761005586 HIGH motif; other site 698761005587 KMSKS motif; other site 698761005588 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698761005589 tRNA binding surface [nucleotide binding]; other site 698761005590 anticodon binding site; other site 698761005591 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698761005592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761005593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761005594 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761005595 putative effector binding pocket; other site 698761005596 dimerization interface [polypeptide binding]; other site 698761005597 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 698761005598 NmrA-like family; Region: NmrA; pfam05368 698761005599 NADP binding site [chemical binding]; other site 698761005600 active site 698761005601 regulatory binding site [polypeptide binding]; other site 698761005602 DNA polymerase III subunit delta'; Validated; Region: PRK09112 698761005603 AAA ATPase domain; Region: AAA_16; pfam13191 698761005604 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698761005605 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698761005606 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698761005607 TMP-binding site; other site 698761005608 ATP-binding site [chemical binding]; other site 698761005609 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698761005610 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 698761005611 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 698761005612 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 698761005613 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 698761005614 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 698761005615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761005616 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698761005617 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 698761005618 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761005619 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761005620 Winged helix-turn helix; Region: HTH_29; pfam13551 698761005621 Homeodomain-like domain; Region: HTH_32; pfam13565 698761005622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698761005623 Integrase core domain; Region: rve; pfam00665 698761005624 Integrase core domain; Region: rve_3; pfam13683 698761005625 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 698761005626 active site 698761005627 DNA binding site [nucleotide binding] 698761005628 Transposase IS200 like; Region: Y1_Tnp; pfam01797 698761005629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761005630 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698761005631 putative substrate translocation pore; other site 698761005632 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 698761005633 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761005634 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761005635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761005636 MarR family; Region: MarR; pfam01047 698761005637 SurA N-terminal domain; Region: SurA_N_3; cl07813 698761005638 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 698761005639 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 698761005640 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698761005641 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698761005642 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698761005643 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698761005644 active site 698761005645 ribulose/triose binding site [chemical binding]; other site 698761005646 phosphate binding site [ion binding]; other site 698761005647 substrate (anthranilate) binding pocket [chemical binding]; other site 698761005648 product (indole) binding pocket [chemical binding]; other site 698761005649 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698761005650 trimer interface [polypeptide binding]; other site 698761005651 dimer interface [polypeptide binding]; other site 698761005652 putative active site [active] 698761005653 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698761005654 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698761005655 dimer interface [polypeptide binding]; other site 698761005656 putative functional site; other site 698761005657 putative MPT binding site; other site 698761005658 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761005659 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 698761005660 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 698761005661 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 698761005662 gating phenylalanine in ion channel; other site 698761005663 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 698761005664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761005665 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 698761005666 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 698761005667 dimer interface [polypeptide binding]; other site 698761005668 active site 698761005669 coenzyme A binding site [chemical binding]; other site 698761005670 citrylCoA binding site [chemical binding]; other site 698761005671 Citrate synthase; Region: Citrate_synt; pfam00285 698761005672 oxalacetate/citrate binding site [chemical binding]; other site 698761005673 catalytic triad [active] 698761005674 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 698761005675 dimer interface [polypeptide binding]; other site 698761005676 Citrate synthase; Region: Citrate_synt; pfam00285 698761005677 active site 698761005678 citrylCoA binding site [chemical binding]; other site 698761005679 oxalacetate/citrate binding site [chemical binding]; other site 698761005680 coenzyme A binding site [chemical binding]; other site 698761005681 catalytic triad [active] 698761005682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761005683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761005684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761005685 dimerization interface [polypeptide binding]; other site 698761005686 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761005687 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 698761005688 CHASE2 domain; Region: CHASE2; pfam05226 698761005689 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761005690 cyclase homology domain; Region: CHD; cd07302 698761005691 nucleotidyl binding site; other site 698761005692 metal binding site [ion binding]; metal-binding site 698761005693 dimer interface [polypeptide binding]; other site 698761005694 FecR protein; Region: FecR; pfam04773 698761005695 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 698761005696 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 698761005697 active site residue [active] 698761005698 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 698761005699 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 698761005700 conserved cys residue [active] 698761005701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761005702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761005703 CTP synthetase; Validated; Region: pyrG; PRK05380 698761005704 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 698761005705 Catalytic site [active] 698761005706 active site 698761005707 UTP binding site [chemical binding]; other site 698761005708 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 698761005709 active site 698761005710 putative oxyanion hole; other site 698761005711 catalytic triad [active] 698761005712 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 698761005713 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698761005714 triosephosphate isomerase; Provisional; Region: PRK14565 698761005715 substrate binding site [chemical binding]; other site 698761005716 dimer interface [polypeptide binding]; other site 698761005717 catalytic triad [active] 698761005718 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698761005719 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 698761005720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761005721 Mg2+ binding site [ion binding]; other site 698761005722 G-X-G motif; other site 698761005723 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698761005724 anchoring element; other site 698761005725 dimer interface [polypeptide binding]; other site 698761005726 ATP binding site [chemical binding]; other site 698761005727 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 698761005728 active site 698761005729 metal binding site [ion binding]; metal-binding site 698761005730 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698761005731 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698761005732 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698761005733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761005734 Coenzyme A binding pocket [chemical binding]; other site 698761005735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 698761005736 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 698761005737 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 698761005738 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 698761005739 putative FMN binding site [chemical binding]; other site 698761005740 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 698761005741 putative acyl-acceptor binding pocket; other site 698761005742 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 698761005743 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 698761005744 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698761005745 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698761005746 active site 698761005747 dimer interface [polypeptide binding]; other site 698761005748 motif 1; other site 698761005749 motif 2; other site 698761005750 motif 3; other site 698761005751 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698761005752 anticodon binding site; other site 698761005753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 698761005754 hypothetical protein; Validated; Region: PRK00041 698761005755 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698761005756 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698761005757 trimerization site [polypeptide binding]; other site 698761005758 active site 698761005759 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698761005760 homodecamer interface [polypeptide binding]; other site 698761005761 GTP cyclohydrolase I; Provisional; Region: PLN03044 698761005762 active site 698761005763 putative catalytic site residues [active] 698761005764 zinc binding site [ion binding]; other site 698761005765 GTP-CH-I/GFRP interaction surface; other site 698761005766 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 698761005767 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698761005768 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 698761005769 nucleophile elbow; other site 698761005770 FOG: CBS domain [General function prediction only]; Region: COG0517 698761005771 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 698761005772 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 698761005773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 698761005774 PAS domain; Region: PAS_5; pfam07310 698761005775 PilZ domain; Region: PilZ; pfam07238 698761005776 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698761005777 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 698761005778 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698761005779 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698761005780 Sporulation related domain; Region: SPOR; pfam05036 698761005781 Uncharacterized conserved protein [Function unknown]; Region: COG5458 698761005782 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698761005783 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698761005784 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 698761005785 Predicted membrane protein [Function unknown]; Region: COG3821 698761005786 Predicted membrane protein [Function unknown]; Region: COG3503 698761005787 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 698761005788 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 698761005789 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 698761005790 DNA binding residues [nucleotide binding] 698761005791 putative dimer interface [polypeptide binding]; other site 698761005792 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698761005793 active site 698761005794 catalytic residues [active] 698761005795 metal binding site [ion binding]; metal-binding site 698761005796 lipoate-protein ligase B; Provisional; Region: PRK14341 698761005797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761005798 non-specific DNA binding site [nucleotide binding]; other site 698761005799 salt bridge; other site 698761005800 sequence-specific DNA binding site [nucleotide binding]; other site 698761005801 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761005802 EamA-like transporter family; Region: EamA; pfam00892 698761005803 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698761005804 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698761005805 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698761005806 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698761005807 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698761005808 carboxyltransferase (CT) interaction site; other site 698761005809 biotinylation site [posttranslational modification]; other site 698761005810 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 698761005811 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 698761005812 substrate binding site [chemical binding]; other site 698761005813 catalytic Zn binding site [ion binding]; other site 698761005814 NAD binding site [chemical binding]; other site 698761005815 structural Zn binding site [ion binding]; other site 698761005816 dimer interface [polypeptide binding]; other site 698761005817 hypothetical protein; Validated; Region: PRK00124 698761005818 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 698761005819 S-formylglutathione hydrolase; Region: PLN02442 698761005820 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698761005821 Predicted membrane protein [Function unknown]; Region: COG2259 698761005822 Predicted membrane protein [Function unknown]; Region: COG2259 698761005823 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698761005824 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698761005825 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 698761005826 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 698761005827 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698761005828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761005829 motif II; other site 698761005830 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698761005831 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698761005832 active site 698761005833 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698761005834 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 698761005835 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761005836 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 698761005837 lipoyl attachment site [posttranslational modification]; other site 698761005838 glycine dehydrogenase; Provisional; Region: PRK05367 698761005839 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 698761005840 tetramer interface [polypeptide binding]; other site 698761005841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761005842 catalytic residue [active] 698761005843 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 698761005844 tetramer interface [polypeptide binding]; other site 698761005845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761005846 catalytic residue [active] 698761005847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761005848 non-specific DNA binding site [nucleotide binding]; other site 698761005849 salt bridge; other site 698761005850 sequence-specific DNA binding site [nucleotide binding]; other site 698761005851 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 698761005852 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 698761005853 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698761005854 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698761005855 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761005856 catalytic residue [active] 698761005857 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698761005858 FeS assembly protein SufD; Region: sufD; TIGR01981 698761005859 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698761005860 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698761005861 Walker A/P-loop; other site 698761005862 ATP binding site [chemical binding]; other site 698761005863 Q-loop/lid; other site 698761005864 ABC transporter signature motif; other site 698761005865 Walker B; other site 698761005866 D-loop; other site 698761005867 H-loop/switch region; other site 698761005868 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 698761005869 putative ABC transporter; Region: ycf24; CHL00085 698761005870 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698761005871 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698761005872 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761005873 catalytic residue [active] 698761005874 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 698761005875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761005876 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761005877 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 698761005878 Caspase domain; Region: Peptidase_C14; pfam00656 698761005879 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698761005880 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698761005881 active site 698761005882 HIGH motif; other site 698761005883 dimer interface [polypeptide binding]; other site 698761005884 KMSKS motif; other site 698761005885 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698761005886 RNA binding surface [nucleotide binding]; other site 698761005887 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 698761005888 Protein of unknown function; Region: DUF3971; pfam13116 698761005889 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 698761005890 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698761005891 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698761005892 catalytic triad [active] 698761005893 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 698761005894 dinuclear metal binding motif [ion binding]; other site 698761005895 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698761005896 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698761005897 ATP binding site [chemical binding]; other site 698761005898 Mg++ binding site [ion binding]; other site 698761005899 motif III; other site 698761005900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761005901 nucleotide binding region [chemical binding]; other site 698761005902 ATP-binding site [chemical binding]; other site 698761005903 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698761005904 nudix motif; other site 698761005905 TfoX N-terminal domain; Region: TfoX_N; pfam04993 698761005906 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 698761005907 putative MPT binding site; other site 698761005908 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 698761005909 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 698761005910 Ligand binding site; other site 698761005911 metal-binding site 698761005912 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 698761005913 XdhC Rossmann domain; Region: XdhC_C; pfam13478 698761005914 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 698761005915 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 698761005916 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698761005917 metal ion-dependent adhesion site (MIDAS); other site 698761005918 MoxR-like ATPases [General function prediction only]; Region: COG0714 698761005919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761005920 Walker A motif; other site 698761005921 ATP binding site [chemical binding]; other site 698761005922 Walker B motif; other site 698761005923 arginine finger; other site 698761005924 Flavin Reductases; Region: FlaRed; cl00801 698761005925 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698761005926 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 698761005927 ligand binding site [chemical binding]; other site 698761005928 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698761005929 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698761005930 substrate binding site [chemical binding]; other site 698761005931 hexamer interface [polypeptide binding]; other site 698761005932 metal binding site [ion binding]; metal-binding site 698761005933 adenylosuccinate lyase; Provisional; Region: PRK07492 698761005934 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 698761005935 tetramer interface [polypeptide binding]; other site 698761005936 active site 698761005937 Low affinity iron permease; Region: Iron_permease; pfam04120 698761005938 Predicted integral membrane protein [Function unknown]; Region: COG5473 698761005939 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 698761005940 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761005941 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698761005942 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 698761005943 ATP binding site [chemical binding]; other site 698761005944 active site 698761005945 substrate binding site [chemical binding]; other site 698761005946 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 698761005947 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 698761005948 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698761005949 putative active site [active] 698761005950 catalytic triad [active] 698761005951 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698761005952 tetramer interface [polypeptide binding]; other site 698761005953 hypothetical protein; Provisional; Region: PRK06815 698761005954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761005955 catalytic residue [active] 698761005956 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698761005957 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698761005958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761005959 DNA-binding site [nucleotide binding]; DNA binding site 698761005960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761005961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761005962 homodimer interface [polypeptide binding]; other site 698761005963 catalytic residue [active] 698761005964 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 698761005965 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 698761005966 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698761005967 dimerization interface [polypeptide binding]; other site 698761005968 ATP binding site [chemical binding]; other site 698761005969 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698761005970 dimerization interface [polypeptide binding]; other site 698761005971 ATP binding site [chemical binding]; other site 698761005972 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 698761005973 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 698761005974 putative GSH binding site [chemical binding]; other site 698761005975 catalytic residues [active] 698761005976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761005977 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 698761005978 putative substrate translocation pore; other site 698761005979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761005980 putative substrate translocation pore; other site 698761005981 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761005982 cyclase homology domain; Region: CHD; cd07302 698761005983 nucleotidyl binding site; other site 698761005984 metal binding site [ion binding]; metal-binding site 698761005985 dimer interface [polypeptide binding]; other site 698761005986 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 698761005987 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698761005988 active site 698761005989 putative lithium-binding site [ion binding]; other site 698761005990 substrate binding site [chemical binding]; other site 698761005991 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 698761005992 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698761005993 active site 698761005994 putative lithium-binding site [ion binding]; other site 698761005995 substrate binding site [chemical binding]; other site 698761005996 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 698761005997 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 698761005998 Ligand Binding Site [chemical binding]; other site 698761005999 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 698761006000 glutaminase; Provisional; Region: PRK00971 698761006001 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698761006002 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698761006003 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698761006004 RNA binding surface [nucleotide binding]; other site 698761006005 Domain of unknown function DUF87; Region: DUF87; pfam01935 698761006006 HerA helicase [Replication, recombination, and repair]; Region: COG0433 698761006007 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 698761006008 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698761006009 phosphate binding site [ion binding]; other site 698761006010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761006011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761006012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761006013 Coenzyme A binding pocket [chemical binding]; other site 698761006014 glutamate racemase; Provisional; Region: PRK00865 698761006015 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 698761006016 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 698761006017 isocitrate dehydrogenase; Validated; Region: PRK08299 698761006018 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761006019 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 698761006020 putative C-terminal domain interface [polypeptide binding]; other site 698761006021 putative GSH binding site (G-site) [chemical binding]; other site 698761006022 putative dimer interface [polypeptide binding]; other site 698761006023 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 698761006024 dimer interface [polypeptide binding]; other site 698761006025 N-terminal domain interface [polypeptide binding]; other site 698761006026 putative substrate binding pocket (H-site) [chemical binding]; other site 698761006027 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761006028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761006029 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 698761006030 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698761006031 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698761006032 motif 1; other site 698761006033 active site 698761006034 motif 2; other site 698761006035 motif 3; other site 698761006036 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698761006037 recombinase A; Provisional; Region: recA; PRK09354 698761006038 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698761006039 hexamer interface [polypeptide binding]; other site 698761006040 Walker A motif; other site 698761006041 ATP binding site [chemical binding]; other site 698761006042 Walker B motif; other site 698761006043 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761006044 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 698761006045 substrate binding site [chemical binding]; other site 698761006046 ATP binding site [chemical binding]; other site 698761006047 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 698761006048 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698761006049 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698761006050 active site 698761006051 HIGH motif; other site 698761006052 dimer interface [polypeptide binding]; other site 698761006053 KMSKS motif; other site 698761006054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761006055 PAS domain; Region: PAS_9; pfam13426 698761006056 putative active site [active] 698761006057 heme pocket [chemical binding]; other site 698761006058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 698761006059 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698761006060 putative active site [active] 698761006061 heme pocket [chemical binding]; other site 698761006062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761006063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761006064 dimer interface [polypeptide binding]; other site 698761006065 phosphorylation site [posttranslational modification] 698761006066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761006067 ATP binding site [chemical binding]; other site 698761006068 Mg2+ binding site [ion binding]; other site 698761006069 G-X-G motif; other site 698761006070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761006071 Response regulator receiver domain; Region: Response_reg; pfam00072 698761006072 active site 698761006073 phosphorylation site [posttranslational modification] 698761006074 intermolecular recognition site; other site 698761006075 dimerization interface [polypeptide binding]; other site 698761006076 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 698761006077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698761006078 catalytic core [active] 698761006079 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698761006080 YcjX-like family, DUF463; Region: DUF463; pfam04317 698761006081 Predicted membrane protein [Function unknown]; Region: COG3768 698761006082 Domain of unknown function (DUF697); Region: DUF697; cl12064 698761006083 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698761006084 catalytic center binding site [active] 698761006085 ATP binding site [chemical binding]; other site 698761006086 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698761006087 homooctamer interface [polypeptide binding]; other site 698761006088 active site 698761006089 dihydropteroate synthase; Region: DHPS; TIGR01496 698761006090 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698761006091 substrate binding pocket [chemical binding]; other site 698761006092 dimer interface [polypeptide binding]; other site 698761006093 inhibitor binding site; inhibition site 698761006094 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 698761006095 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698761006096 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761006097 catalytic loop [active] 698761006098 iron binding site [ion binding]; other site 698761006099 Hpt domain; Region: Hpt; pfam01627 698761006100 putative binding surface; other site 698761006101 active site 698761006102 Predicted membrane protein [Function unknown]; Region: COG1511 698761006103 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 698761006104 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 698761006105 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 698761006106 inhibitor binding site; inhibition site 698761006107 active site 698761006108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761006109 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761006110 active site 698761006111 catalytic tetrad [active] 698761006112 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761006113 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761006114 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761006115 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 698761006116 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698761006117 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 698761006118 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761006119 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761006120 Walker A/P-loop; other site 698761006121 ATP binding site [chemical binding]; other site 698761006122 Q-loop/lid; other site 698761006123 ABC transporter signature motif; other site 698761006124 Walker B; other site 698761006125 D-loop; other site 698761006126 H-loop/switch region; other site 698761006127 TOBE domain; Region: TOBE_2; pfam08402 698761006128 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761006129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006130 dimer interface [polypeptide binding]; other site 698761006131 conserved gate region; other site 698761006132 putative PBP binding loops; other site 698761006133 ABC-ATPase subunit interface; other site 698761006134 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761006135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006136 dimer interface [polypeptide binding]; other site 698761006137 conserved gate region; other site 698761006138 putative PBP binding loops; other site 698761006139 ABC-ATPase subunit interface; other site 698761006140 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761006141 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761006142 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761006143 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761006144 DNA binding site [nucleotide binding] 698761006145 domain linker motif; other site 698761006146 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698761006147 ligand binding site [chemical binding]; other site 698761006148 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 698761006149 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761006150 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698761006151 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 698761006152 hydrophobic ligand binding site; other site 698761006153 Protein of unknown function (DUF330); Region: DUF330; cl01135 698761006154 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 698761006155 mce related protein; Region: MCE; pfam02470 698761006156 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 698761006157 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 698761006158 Walker A/P-loop; other site 698761006159 ATP binding site [chemical binding]; other site 698761006160 Q-loop/lid; other site 698761006161 ABC transporter signature motif; other site 698761006162 Walker B; other site 698761006163 D-loop; other site 698761006164 H-loop/switch region; other site 698761006165 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 698761006166 anti sigma factor interaction site; other site 698761006167 regulatory phosphorylation site [posttranslational modification]; other site 698761006168 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 698761006169 Permease; Region: Permease; pfam02405 698761006170 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 698761006171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761006172 putative substrate translocation pore; other site 698761006173 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761006174 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 698761006175 putative active site [active] 698761006176 putative metal binding site [ion binding]; other site 698761006177 malic enzyme; Reviewed; Region: PRK12862 698761006178 Malic enzyme, N-terminal domain; Region: malic; pfam00390 698761006179 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 698761006180 putative NAD(P) binding site [chemical binding]; other site 698761006181 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 698761006182 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 698761006183 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 698761006184 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 698761006185 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 698761006186 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 698761006187 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 698761006188 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698761006189 NAD synthetase; Provisional; Region: PRK13981 698761006190 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 698761006191 multimer interface [polypeptide binding]; other site 698761006192 active site 698761006193 catalytic triad [active] 698761006194 protein interface 1 [polypeptide binding]; other site 698761006195 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698761006196 homodimer interface [polypeptide binding]; other site 698761006197 NAD binding pocket [chemical binding]; other site 698761006198 ATP binding pocket [chemical binding]; other site 698761006199 Mg binding site [ion binding]; other site 698761006200 active-site loop [active] 698761006201 Predicted membrane protein [Function unknown]; Region: COG4420 698761006202 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761006203 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 698761006204 glutathione reductase; Validated; Region: PRK06116 698761006205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761006206 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698761006207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 698761006208 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 698761006209 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698761006210 active site 698761006211 dimer interface [polypeptide binding]; other site 698761006212 phosphoglycolate phosphatase; Provisional; Region: PRK13222 698761006213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761006214 motif II; other site 698761006215 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 698761006216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761006217 binding surface 698761006218 TPR motif; other site 698761006219 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 698761006220 catalytic motif [active] 698761006221 Catalytic residue [active] 698761006222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 698761006223 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761006224 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761006225 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761006226 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698761006227 Class II fumarases; Region: Fumarase_classII; cd01362 698761006228 active site 698761006229 tetramer interface [polypeptide binding]; other site 698761006230 fumarate hydratase; Provisional; Region: PRK15389 698761006231 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 698761006232 Fumarase C-terminus; Region: Fumerase_C; pfam05683 698761006233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761006234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761006235 metal binding site [ion binding]; metal-binding site 698761006236 active site 698761006237 I-site; other site 698761006238 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 698761006239 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761006240 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761006241 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761006242 MarR family; Region: MarR_2; pfam12802 698761006243 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 698761006244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 698761006245 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 698761006246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761006247 FeS/SAM binding site; other site 698761006248 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698761006249 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698761006250 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 698761006251 HAMP domain; Region: HAMP; pfam00672 698761006252 dimerization interface [polypeptide binding]; other site 698761006253 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761006254 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761006255 dimer interface [polypeptide binding]; other site 698761006256 putative CheW interface [polypeptide binding]; other site 698761006257 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761006258 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 698761006259 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698761006260 GTP binding site; other site 698761006261 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 698761006262 Walker A motif; other site 698761006263 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 698761006264 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698761006265 ligand binding site [chemical binding]; other site 698761006266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761006267 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761006268 substrate binding pocket [chemical binding]; other site 698761006269 membrane-bound complex binding site; other site 698761006270 hinge residues; other site 698761006271 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761006272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006273 dimer interface [polypeptide binding]; other site 698761006274 conserved gate region; other site 698761006275 putative PBP binding loops; other site 698761006276 ABC-ATPase subunit interface; other site 698761006277 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761006278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006279 dimer interface [polypeptide binding]; other site 698761006280 conserved gate region; other site 698761006281 putative PBP binding loops; other site 698761006282 ABC-ATPase subunit interface; other site 698761006283 Usg-like family; Region: Usg; cl11567 698761006284 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 698761006285 Tetratricopeptide repeats; Region: TPR; smart00028 698761006286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761006287 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761006288 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 698761006289 C-terminal domain interface [polypeptide binding]; other site 698761006290 GSH binding site (G-site) [chemical binding]; other site 698761006291 dimer interface [polypeptide binding]; other site 698761006292 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 698761006293 N-terminal domain interface [polypeptide binding]; other site 698761006294 dimer interface [polypeptide binding]; other site 698761006295 substrate binding pocket (H-site) [chemical binding]; other site 698761006296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761006297 dimerization interface [polypeptide binding]; other site 698761006298 putative DNA binding site [nucleotide binding]; other site 698761006299 putative Zn2+ binding site [ion binding]; other site 698761006300 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 698761006301 putative hydrophobic ligand binding site [chemical binding]; other site 698761006302 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761006303 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761006304 Walker A/P-loop; other site 698761006305 ATP binding site [chemical binding]; other site 698761006306 Q-loop/lid; other site 698761006307 ABC transporter signature motif; other site 698761006308 Walker B; other site 698761006309 D-loop; other site 698761006310 H-loop/switch region; other site 698761006311 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761006312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006313 dimer interface [polypeptide binding]; other site 698761006314 conserved gate region; other site 698761006315 putative PBP binding loops; other site 698761006316 ABC-ATPase subunit interface; other site 698761006317 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 698761006318 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 698761006319 active site 698761006320 dimer interface [polypeptide binding]; other site 698761006321 non-prolyl cis peptide bond; other site 698761006322 insertion regions; other site 698761006323 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 698761006324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761006325 membrane-bound complex binding site; other site 698761006326 hinge residues; other site 698761006327 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761006328 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761006329 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761006330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761006331 putative DNA binding site [nucleotide binding]; other site 698761006332 putative Zn2+ binding site [ion binding]; other site 698761006333 AsnC family; Region: AsnC_trans_reg; pfam01037 698761006334 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 698761006335 putative uracil binding site [chemical binding]; other site 698761006336 putative active site [active] 698761006337 Staphylococcal nuclease homologues; Region: SNc; smart00318 698761006338 Catalytic site; other site 698761006339 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 698761006340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761006341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761006342 dimer interface [polypeptide binding]; other site 698761006343 phosphorylation site [posttranslational modification] 698761006344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761006345 ATP binding site [chemical binding]; other site 698761006346 Mg2+ binding site [ion binding]; other site 698761006347 G-X-G motif; other site 698761006348 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 698761006349 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698761006350 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698761006351 putative dimer interface [polypeptide binding]; other site 698761006352 active site pocket [active] 698761006353 putative cataytic base [active] 698761006354 cobalamin synthase; Reviewed; Region: cobS; PRK00235 698761006355 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 698761006356 Predicted aspartyl protease [General function prediction only]; Region: COG3577 698761006357 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 698761006358 catalytic motif [active] 698761006359 Catalytic residue [active] 698761006360 EamA-like transporter family; Region: EamA; pfam00892 698761006361 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 698761006362 EamA-like transporter family; Region: EamA; cl17759 698761006363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761006364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761006365 Coenzyme A binding pocket [chemical binding]; other site 698761006366 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698761006367 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698761006368 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698761006369 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698761006370 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698761006371 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698761006372 Walker A/P-loop; other site 698761006373 ATP binding site [chemical binding]; other site 698761006374 Q-loop/lid; other site 698761006375 ABC transporter signature motif; other site 698761006376 Walker B; other site 698761006377 D-loop; other site 698761006378 H-loop/switch region; other site 698761006379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 698761006380 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 698761006381 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 698761006382 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698761006383 Sel1-like repeats; Region: SEL1; smart00671 698761006384 Sel1-like repeats; Region: SEL1; smart00671 698761006385 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698761006386 Sel1-like repeats; Region: SEL1; smart00671 698761006387 Sel1-like repeats; Region: SEL1; smart00671 698761006388 Sel1-like repeats; Region: SEL1; smart00671 698761006389 Sel1-like repeats; Region: SEL1; smart00671 698761006390 Sel1-like repeats; Region: SEL1; smart00671 698761006391 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698761006392 Sel1-like repeats; Region: SEL1; smart00671 698761006393 Sel1-like repeats; Region: SEL1; smart00671 698761006394 Sel1-like repeats; Region: SEL1; smart00671 698761006395 Sel1-like repeats; Region: SEL1; smart00671 698761006396 Sel1-like repeats; Region: SEL1; smart00671 698761006397 Sel1-like repeats; Region: SEL1; smart00671 698761006398 Sel1-like repeats; Region: SEL1; smart00671 698761006399 putative sialic acid transporter; Region: 2A0112; TIGR00891 698761006400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761006401 putative substrate translocation pore; other site 698761006402 excinuclease ABC subunit B; Provisional; Region: PRK05298 698761006403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698761006404 ATP binding site [chemical binding]; other site 698761006405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761006406 nucleotide binding region [chemical binding]; other site 698761006407 ATP-binding site [chemical binding]; other site 698761006408 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698761006409 UvrB/uvrC motif; Region: UVR; pfam02151 698761006410 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698761006411 putative hydrophobic ligand binding site [chemical binding]; other site 698761006412 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761006413 cyclase homology domain; Region: CHD; cd07302 698761006414 nucleotidyl binding site; other site 698761006415 metal binding site [ion binding]; metal-binding site 698761006416 dimer interface [polypeptide binding]; other site 698761006417 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698761006418 DNA-binding site [nucleotide binding]; DNA binding site 698761006419 RNA-binding motif; other site 698761006420 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 698761006421 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698761006422 FMN binding site [chemical binding]; other site 698761006423 active site 698761006424 catalytic residues [active] 698761006425 substrate binding site [chemical binding]; other site 698761006426 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698761006427 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698761006428 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698761006429 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698761006430 trimer interface [polypeptide binding]; other site 698761006431 putative metal binding site [ion binding]; other site 698761006432 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698761006433 metal binding site 2 [ion binding]; metal-binding site 698761006434 putative DNA binding helix; other site 698761006435 metal binding site 1 [ion binding]; metal-binding site 698761006436 dimer interface [polypeptide binding]; other site 698761006437 structural Zn2+ binding site [ion binding]; other site 698761006438 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698761006439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698761006440 ABC-ATPase subunit interface; other site 698761006441 dimer interface [polypeptide binding]; other site 698761006442 putative PBP binding regions; other site 698761006443 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 698761006444 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698761006445 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 698761006446 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 698761006447 metal binding site [ion binding]; metal-binding site 698761006448 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698761006449 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698761006450 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698761006451 PAS fold; Region: PAS_4; pfam08448 698761006452 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698761006453 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698761006454 putative acyl-acceptor binding pocket; other site 698761006455 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698761006456 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698761006457 NAD(P) binding site [chemical binding]; other site 698761006458 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 698761006459 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698761006460 dimer interface [polypeptide binding]; other site 698761006461 active site 698761006462 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 698761006463 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 698761006464 active site 698761006465 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 698761006466 acyl carrier protein; Provisional; Region: PRK06508 698761006467 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761006468 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 698761006469 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 698761006470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761006471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761006472 homodimer interface [polypeptide binding]; other site 698761006473 catalytic residue [active] 698761006474 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698761006475 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698761006476 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698761006477 active site 698761006478 SAM binding site [chemical binding]; other site 698761006479 homodimer interface [polypeptide binding]; other site 698761006480 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698761006481 active site 698761006482 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 698761006483 hypothetical protein; Provisional; Region: PRK10621 698761006484 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698761006485 SnoaL-like domain; Region: SnoaL_2; pfam12680 698761006486 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761006487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761006488 non-specific DNA binding site [nucleotide binding]; other site 698761006489 salt bridge; other site 698761006490 sequence-specific DNA binding site [nucleotide binding]; other site 698761006491 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698761006492 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 698761006493 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698761006494 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698761006495 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698761006496 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698761006497 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 698761006498 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698761006499 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698761006500 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698761006501 homotrimer interface [polypeptide binding]; other site 698761006502 Walker A motif; other site 698761006503 GTP binding site [chemical binding]; other site 698761006504 Walker B motif; other site 698761006505 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 698761006506 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 698761006507 Cl- selectivity filter; other site 698761006508 Cl- binding residues [ion binding]; other site 698761006509 pore gating glutamate residue; other site 698761006510 dimer interface [polypeptide binding]; other site 698761006511 FOG: CBS domain [General function prediction only]; Region: COG0517 698761006512 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698761006513 cobyric acid synthase; Provisional; Region: PRK00784 698761006514 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 698761006515 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698761006516 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698761006517 catalytic triad [active] 698761006518 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698761006519 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698761006520 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 698761006521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006522 dimer interface [polypeptide binding]; other site 698761006523 conserved gate region; other site 698761006524 ABC-ATPase subunit interface; other site 698761006525 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 698761006526 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 698761006527 Walker A/P-loop; other site 698761006528 ATP binding site [chemical binding]; other site 698761006529 Q-loop/lid; other site 698761006530 ABC transporter signature motif; other site 698761006531 Walker B; other site 698761006532 D-loop; other site 698761006533 H-loop/switch region; other site 698761006534 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 698761006535 methionine synthase I; Validated; Region: PRK07534 698761006536 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 698761006537 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698761006538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761006539 UDP-galactopyranose mutase; Region: GLF; pfam03275 698761006540 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698761006541 Predicted periplasmic protein [Function unknown]; Region: COG3698 698761006542 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 698761006543 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 698761006544 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 698761006545 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 698761006546 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 698761006547 B12 binding site [chemical binding]; other site 698761006548 cobalt ligand [ion binding]; other site 698761006549 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 698761006550 Virulence factor; Region: Virulence_fact; pfam13769 698761006551 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 698761006552 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698761006553 FAD binding site [chemical binding]; other site 698761006554 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 698761006555 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 698761006556 substrate binding pocket [chemical binding]; other site 698761006557 dimer interface [polypeptide binding]; other site 698761006558 inhibitor binding site; inhibition site 698761006559 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 698761006560 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761006561 catalytic loop [active] 698761006562 iron binding site [ion binding]; other site 698761006563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761006564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761006565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761006566 dimerization interface [polypeptide binding]; other site 698761006567 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 698761006568 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698761006569 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 698761006570 conserved cys residue [active] 698761006571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761006572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761006573 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698761006574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761006575 active site 698761006576 phosphorylation site [posttranslational modification] 698761006577 intermolecular recognition site; other site 698761006578 dimerization interface [polypeptide binding]; other site 698761006579 Response regulator receiver domain; Region: Response_reg; pfam00072 698761006580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761006581 active site 698761006582 phosphorylation site [posttranslational modification] 698761006583 intermolecular recognition site; other site 698761006584 dimerization interface [polypeptide binding]; other site 698761006585 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761006586 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761006587 metal binding site [ion binding]; metal-binding site 698761006588 active site 698761006589 I-site; other site 698761006590 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698761006591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 698761006592 active site 698761006593 phosphorylation site [posttranslational modification] 698761006594 intermolecular recognition site; other site 698761006595 dimerization interface [polypeptide binding]; other site 698761006596 Response regulator receiver domain; Region: Response_reg; pfam00072 698761006597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761006598 active site 698761006599 phosphorylation site [posttranslational modification] 698761006600 intermolecular recognition site; other site 698761006601 dimerization interface [polypeptide binding]; other site 698761006602 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 698761006603 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698761006604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 698761006605 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698761006606 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761006607 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761006608 active site 698761006609 Predicted transcriptional regulator [Transcription]; Region: COG1959 698761006610 Transcriptional regulator; Region: Rrf2; pfam02082 698761006611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 698761006612 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698761006613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761006614 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698761006615 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698761006616 putative metal binding site [ion binding]; other site 698761006617 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 698761006618 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 698761006619 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 698761006620 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761006621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761006622 Walker A/P-loop; other site 698761006623 ATP binding site [chemical binding]; other site 698761006624 Q-loop/lid; other site 698761006625 ABC transporter signature motif; other site 698761006626 Walker B; other site 698761006627 D-loop; other site 698761006628 H-loop/switch region; other site 698761006629 TOBE domain; Region: TOBE_2; pfam08402 698761006630 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698761006631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006632 dimer interface [polypeptide binding]; other site 698761006633 conserved gate region; other site 698761006634 putative PBP binding loops; other site 698761006635 ABC-ATPase subunit interface; other site 698761006636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006637 dimer interface [polypeptide binding]; other site 698761006638 conserved gate region; other site 698761006639 putative PBP binding loops; other site 698761006640 ABC-ATPase subunit interface; other site 698761006641 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698761006642 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698761006643 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761006644 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761006645 active site 698761006646 catalytic tetrad [active] 698761006647 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 698761006648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761006649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761006650 homodimer interface [polypeptide binding]; other site 698761006651 catalytic residue [active] 698761006652 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 698761006653 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 698761006654 putative active site [active] 698761006655 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698761006656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761006657 S-adenosylmethionine binding site [chemical binding]; other site 698761006658 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698761006659 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698761006660 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698761006661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761006662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761006663 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698761006664 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761006665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761006666 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698761006667 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 698761006668 putative NAD(P) binding site [chemical binding]; other site 698761006669 putative substrate binding site [chemical binding]; other site 698761006670 catalytic Zn binding site [ion binding]; other site 698761006671 structural Zn binding site [ion binding]; other site 698761006672 dimer interface [polypeptide binding]; other site 698761006673 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698761006674 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761006675 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761006676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761006677 putative DNA binding site [nucleotide binding]; other site 698761006678 putative Zn2+ binding site [ion binding]; other site 698761006679 AsnC family; Region: AsnC_trans_reg; pfam01037 698761006680 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 698761006681 aspartate racemase; Region: asp_race; TIGR00035 698761006682 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761006683 MarR family; Region: MarR_2; pfam12802 698761006684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761006685 Coenzyme A binding pocket [chemical binding]; other site 698761006686 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698761006687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761006688 Coenzyme A binding pocket [chemical binding]; other site 698761006689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761006690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761006691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761006692 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761006693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761006694 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761006695 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 698761006696 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761006697 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698761006698 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698761006699 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 698761006700 NADP binding site [chemical binding]; other site 698761006701 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 698761006702 active site 698761006703 hydrophilic channel; other site 698761006704 dimerization interface [polypeptide binding]; other site 698761006705 catalytic residues [active] 698761006706 active site lid [active] 698761006707 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 698761006708 AAA domain; Region: AAA_30; pfam13604 698761006709 Family description; Region: UvrD_C_2; pfam13538 698761006710 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 698761006711 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 698761006712 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698761006713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761006714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761006715 DNA binding residues [nucleotide binding] 698761006716 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698761006717 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 698761006718 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 698761006719 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 698761006720 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 698761006721 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 698761006722 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761006723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761006724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761006725 active site 698761006726 catalytic tetrad [active] 698761006727 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 698761006728 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698761006729 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698761006730 putative valine binding site [chemical binding]; other site 698761006731 dimer interface [polypeptide binding]; other site 698761006732 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698761006733 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 698761006734 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698761006735 PYR/PP interface [polypeptide binding]; other site 698761006736 dimer interface [polypeptide binding]; other site 698761006737 TPP binding site [chemical binding]; other site 698761006738 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698761006739 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698761006740 TPP-binding site [chemical binding]; other site 698761006741 dimer interface [polypeptide binding]; other site 698761006742 HerA helicase [Replication, recombination, and repair]; Region: COG0433 698761006743 Domain of unknown function DUF87; Region: DUF87; pfam01935 698761006744 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698761006745 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698761006746 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698761006747 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761006748 motif II; other site 698761006749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761006750 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 698761006751 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698761006752 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761006753 protein binding site [polypeptide binding]; other site 698761006754 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761006755 protein binding site [polypeptide binding]; other site 698761006756 HflC protein; Region: hflC; TIGR01932 698761006757 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 698761006758 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 698761006759 HflK protein; Region: hflK; TIGR01933 698761006760 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698761006761 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698761006762 folate binding site [chemical binding]; other site 698761006763 NADP+ binding site [chemical binding]; other site 698761006764 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761006765 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761006766 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 698761006767 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761006768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761006769 non-specific DNA binding site [nucleotide binding]; other site 698761006770 salt bridge; other site 698761006771 sequence-specific DNA binding site [nucleotide binding]; other site 698761006772 Cupin domain; Region: Cupin_2; cl17218 698761006773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 698761006774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761006775 Coenzyme A binding pocket [chemical binding]; other site 698761006776 thymidylate synthase; Reviewed; Region: thyA; PRK01827 698761006777 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698761006778 dimerization interface [polypeptide binding]; other site 698761006779 active site 698761006780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 698761006781 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 698761006782 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 698761006783 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 698761006784 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698761006785 FAD binding domain; Region: FAD_binding_4; pfam01565 698761006786 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761006787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761006788 substrate binding pocket [chemical binding]; other site 698761006789 membrane-bound complex binding site; other site 698761006790 hinge residues; other site 698761006791 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 698761006792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006793 dimer interface [polypeptide binding]; other site 698761006794 ABC-ATPase subunit interface; other site 698761006795 putative PBP binding loops; other site 698761006796 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 698761006797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761006798 putative PBP binding loops; other site 698761006799 dimer interface [polypeptide binding]; other site 698761006800 ABC-ATPase subunit interface; other site 698761006801 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761006802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761006803 Walker A/P-loop; other site 698761006804 ATP binding site [chemical binding]; other site 698761006805 Q-loop/lid; other site 698761006806 ABC transporter signature motif; other site 698761006807 Walker B; other site 698761006808 D-loop; other site 698761006809 H-loop/switch region; other site 698761006810 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761006811 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761006812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761006813 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 698761006814 putative outer membrane lipoprotein; Provisional; Region: PRK10510 698761006815 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698761006816 ligand binding site [chemical binding]; other site 698761006817 flagellin; Reviewed; Region: PRK12687 698761006818 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 698761006819 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698761006820 Part of AAA domain; Region: AAA_19; pfam13245 698761006821 Family description; Region: UvrD_C_2; pfam13538 698761006822 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 698761006823 GIY-YIG motif/motif A; other site 698761006824 putative active site [active] 698761006825 putative metal binding site [ion binding]; other site 698761006826 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761006827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761006828 dimerization interface [polypeptide binding]; other site 698761006829 putative DNA binding site [nucleotide binding]; other site 698761006830 putative Zn2+ binding site [ion binding]; other site 698761006831 glutathionine S-transferase; Provisional; Region: PRK10542 698761006832 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 698761006833 C-terminal domain interface [polypeptide binding]; other site 698761006834 GSH binding site (G-site) [chemical binding]; other site 698761006835 dimer interface [polypeptide binding]; other site 698761006836 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 698761006837 dimer interface [polypeptide binding]; other site 698761006838 N-terminal domain interface [polypeptide binding]; other site 698761006839 substrate binding pocket (H-site) [chemical binding]; other site 698761006840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761006841 short chain dehydrogenase; Provisional; Region: PRK12937 698761006842 NAD(P) binding site [chemical binding]; other site 698761006843 active site 698761006844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761006845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761006846 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 698761006847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761006848 putative substrate translocation pore; other site 698761006849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 698761006850 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 698761006851 Isochorismatase family; Region: Isochorismatase; pfam00857 698761006852 catalytic triad [active] 698761006853 metal binding site [ion binding]; metal-binding site 698761006854 conserved cis-peptide bond; other site 698761006855 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 698761006856 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761006857 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761006858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761006859 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698761006860 dimerization interface [polypeptide binding]; other site 698761006861 substrate binding pocket [chemical binding]; other site 698761006862 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 698761006863 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 698761006864 putative NAD(P) binding site [chemical binding]; other site 698761006865 putative active site [active] 698761006866 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698761006867 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698761006868 active site 698761006869 ATP-binding site [chemical binding]; other site 698761006870 pantoate-binding site; other site 698761006871 HXXH motif; other site 698761006872 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698761006873 active site 698761006874 oligomerization interface [polypeptide binding]; other site 698761006875 metal binding site [ion binding]; metal-binding site 698761006876 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 698761006877 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698761006878 Predicted membrane protein [Function unknown]; Region: COG4541 698761006879 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761006880 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698761006881 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761006882 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 698761006883 active site 698761006884 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 698761006885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761006886 S-adenosylmethionine binding site [chemical binding]; other site 698761006887 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 698761006888 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761006889 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 698761006890 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 698761006891 Cu(I) binding site [ion binding]; other site 698761006892 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 698761006893 putative CheA interaction surface; other site 698761006894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 698761006895 CreA protein; Region: CreA; pfam05981 698761006896 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 698761006897 putative hydrophobic ligand binding site [chemical binding]; other site 698761006898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761006899 dimerization interface [polypeptide binding]; other site 698761006900 putative DNA binding site [nucleotide binding]; other site 698761006901 putative Zn2+ binding site [ion binding]; other site 698761006902 putative acetyltransferase YhhY; Provisional; Region: PRK10140 698761006903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761006904 Coenzyme A binding pocket [chemical binding]; other site 698761006905 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698761006906 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698761006907 nucleotide binding pocket [chemical binding]; other site 698761006908 K-X-D-G motif; other site 698761006909 catalytic site [active] 698761006910 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698761006911 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698761006912 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698761006913 Dimer interface [polypeptide binding]; other site 698761006914 BRCT sequence motif; other site 698761006915 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 698761006916 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 698761006917 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 698761006918 trimer interface [polypeptide binding]; other site 698761006919 active site 698761006920 substrate binding site [chemical binding]; other site 698761006921 CoA binding site [chemical binding]; other site 698761006922 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698761006923 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698761006924 Walker A/P-loop; other site 698761006925 ATP binding site [chemical binding]; other site 698761006926 Q-loop/lid; other site 698761006927 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698761006928 ABC transporter signature motif; other site 698761006929 Walker B; other site 698761006930 D-loop; other site 698761006931 H-loop/switch region; other site 698761006932 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 698761006933 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 698761006934 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 698761006935 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698761006936 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698761006937 nucleotide binding site [chemical binding]; other site 698761006938 SulA interaction site; other site 698761006939 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 698761006940 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 698761006941 Cell division protein FtsA; Region: FtsA; smart00842 698761006942 Cell division protein FtsA; Region: FtsA; pfam14450 698761006943 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 698761006944 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698761006945 Cell division protein FtsQ; Region: FtsQ; pfam03799 698761006946 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 698761006947 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698761006948 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698761006949 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 698761006950 amphipathic channel; other site 698761006951 Asn-Pro-Ala signature motifs; other site 698761006952 metabolite-proton symporter; Region: 2A0106; TIGR00883 698761006953 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 698761006954 FAD binding domain; Region: FAD_binding_4; pfam01565 698761006955 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698761006956 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698761006957 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698761006958 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698761006959 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698761006960 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698761006961 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698761006962 active site 698761006963 homodimer interface [polypeptide binding]; other site 698761006964 cell division protein FtsW; Region: ftsW; TIGR02614 698761006965 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 698761006966 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 698761006967 NAD(P) binding pocket [chemical binding]; other site 698761006968 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698761006969 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698761006970 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698761006971 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698761006972 Mg++ binding site [ion binding]; other site 698761006973 putative catalytic motif [active] 698761006974 putative substrate binding site [chemical binding]; other site 698761006975 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 698761006976 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698761006977 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698761006978 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698761006979 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698761006980 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698761006981 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698761006982 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698761006983 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698761006984 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698761006985 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 698761006986 MraW methylase family; Region: Methyltransf_5; cl17771 698761006987 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 698761006988 cell division protein MraZ; Reviewed; Region: PRK00326 698761006989 MraZ protein; Region: MraZ; pfam02381 698761006990 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761006991 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698761006992 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698761006993 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698761006994 catalytic residue [active] 698761006995 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 698761006996 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698761006997 amidase catalytic site [active] 698761006998 Zn binding residues [ion binding]; other site 698761006999 substrate binding site [chemical binding]; other site 698761007000 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761007001 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 698761007002 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 698761007003 putative metal binding site [ion binding]; other site 698761007004 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698761007005 HSP70 interaction site [polypeptide binding]; other site 698761007006 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 698761007007 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 698761007008 active site 698761007009 ADP/pyrophosphate binding site [chemical binding]; other site 698761007010 dimerization interface [polypeptide binding]; other site 698761007011 allosteric effector site; other site 698761007012 fructose-1,6-bisphosphate binding site; other site 698761007013 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761007014 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 698761007015 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698761007016 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698761007017 catalytic residue [active] 698761007018 Beta-lactamase; Region: Beta-lactamase; pfam00144 698761007019 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698761007020 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 698761007021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761007022 S-adenosylmethionine binding site [chemical binding]; other site 698761007023 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 698761007024 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698761007025 active site 698761007026 lytic murein transglycosylase; Region: MltB_2; TIGR02283 698761007027 murein hydrolase B; Provisional; Region: PRK10760; cl17906 698761007028 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761007029 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 698761007030 EamA-like transporter family; Region: EamA; pfam00892 698761007031 EamA-like transporter family; Region: EamA; pfam00892 698761007032 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698761007033 FAD binding site [chemical binding]; other site 698761007034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761007035 putative DNA binding site [nucleotide binding]; other site 698761007036 dimerization interface [polypeptide binding]; other site 698761007037 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698761007038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761007039 S-adenosylmethionine binding site [chemical binding]; other site 698761007040 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698761007041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761007042 Walker A/P-loop; other site 698761007043 ATP binding site [chemical binding]; other site 698761007044 Q-loop/lid; other site 698761007045 ABC transporter signature motif; other site 698761007046 Walker B; other site 698761007047 D-loop; other site 698761007048 H-loop/switch region; other site 698761007049 ABC transporter; Region: ABC_tran_2; pfam12848 698761007050 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761007051 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 698761007052 B1 nucleotide binding pocket [chemical binding]; other site 698761007053 B2 nucleotide binding pocket [chemical binding]; other site 698761007054 CAS motifs; other site 698761007055 active site 698761007056 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698761007057 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761007058 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 698761007059 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761007060 EamA-like transporter family; Region: EamA; pfam00892 698761007061 EamA-like transporter family; Region: EamA; cl17759 698761007062 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 698761007063 CoA-transferase family III; Region: CoA_transf_3; pfam02515 698761007064 thiamine pyrophosphate protein; Validated; Region: PRK08199 698761007065 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698761007066 PYR/PP interface [polypeptide binding]; other site 698761007067 dimer interface [polypeptide binding]; other site 698761007068 TPP binding site [chemical binding]; other site 698761007069 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698761007070 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 698761007071 TPP-binding site [chemical binding]; other site 698761007072 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 698761007073 homotrimer interaction site [polypeptide binding]; other site 698761007074 putative active site [active] 698761007075 Putative phosphatase (DUF442); Region: DUF442; cl17385 698761007076 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698761007077 active site 698761007078 catalytic residues [active] 698761007079 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761007080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698761007081 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761007082 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 698761007083 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 698761007084 putative active site [active] 698761007085 metal binding site [ion binding]; metal-binding site 698761007086 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 698761007087 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 698761007088 NAD(P) binding site [chemical binding]; other site 698761007089 catalytic residues [active] 698761007090 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698761007091 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698761007092 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698761007093 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 698761007094 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 698761007095 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698761007096 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698761007097 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698761007098 putative active site [active] 698761007099 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698761007100 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698761007101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007102 dimer interface [polypeptide binding]; other site 698761007103 conserved gate region; other site 698761007104 putative PBP binding loops; other site 698761007105 ABC-ATPase subunit interface; other site 698761007106 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761007107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007108 dimer interface [polypeptide binding]; other site 698761007109 conserved gate region; other site 698761007110 putative PBP binding loops; other site 698761007111 ABC-ATPase subunit interface; other site 698761007112 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761007113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761007114 Walker A/P-loop; other site 698761007115 ATP binding site [chemical binding]; other site 698761007116 Q-loop/lid; other site 698761007117 ABC transporter signature motif; other site 698761007118 Walker B; other site 698761007119 D-loop; other site 698761007120 H-loop/switch region; other site 698761007121 TOBE domain; Region: TOBE_2; pfam08402 698761007122 riboflavin synthase subunit beta; Provisional; Region: PRK12419 698761007123 active site 698761007124 homopentamer interface [polypeptide binding]; other site 698761007125 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 698761007126 dimer interface [polypeptide binding]; other site 698761007127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761007128 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 698761007129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761007130 DNA-binding site [nucleotide binding]; DNA binding site 698761007131 UTRA domain; Region: UTRA; pfam07702 698761007132 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761007133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761007134 S-adenosylmethionine binding site [chemical binding]; other site 698761007135 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761007136 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 698761007137 dimer interface [polypeptide binding]; other site 698761007138 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 698761007139 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761007140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761007141 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761007142 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761007143 Walker A/P-loop; other site 698761007144 ATP binding site [chemical binding]; other site 698761007145 Q-loop/lid; other site 698761007146 ABC transporter signature motif; other site 698761007147 Walker B; other site 698761007148 D-loop; other site 698761007149 H-loop/switch region; other site 698761007150 TOBE domain; Region: TOBE_2; pfam08402 698761007151 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761007152 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761007153 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761007154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007155 dimer interface [polypeptide binding]; other site 698761007156 conserved gate region; other site 698761007157 putative PBP binding loops; other site 698761007158 ABC-ATPase subunit interface; other site 698761007159 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698761007160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007161 dimer interface [polypeptide binding]; other site 698761007162 conserved gate region; other site 698761007163 putative PBP binding loops; other site 698761007164 ABC-ATPase subunit interface; other site 698761007165 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761007166 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761007167 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 698761007168 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698761007169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761007170 DNA-binding site [nucleotide binding]; DNA binding site 698761007171 UTRA domain; Region: UTRA; pfam07702 698761007172 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 698761007173 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698761007174 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698761007175 substrate binding pocket [chemical binding]; other site 698761007176 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698761007177 B12 binding site [chemical binding]; other site 698761007178 cobalt ligand [ion binding]; other site 698761007179 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698761007180 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 698761007181 dimerization interface [polypeptide binding]; other site 698761007182 putative active cleft [active] 698761007183 hypothetical protein; Provisional; Region: PRK02487 698761007184 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 698761007185 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761007186 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698761007187 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 698761007188 Putative phage tail protein; Region: Phage-tail_3; pfam13550 698761007189 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 698761007190 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 698761007191 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761007192 MULE transposase domain; Region: MULE; pfam10551 698761007193 putative transposase OrfB; Reviewed; Region: PHA02517 698761007194 HTH-like domain; Region: HTH_21; pfam13276 698761007195 Integrase core domain; Region: rve; pfam00665 698761007196 Integrase core domain; Region: rve_2; pfam13333 698761007197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761007198 Transposase; Region: HTH_Tnp_1; pfam01527 698761007199 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761007200 MULE transposase domain; Region: MULE; pfam10551 698761007201 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 698761007202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 698761007203 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 698761007204 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 698761007205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 698761007206 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 698761007207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 698761007208 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 698761007209 Predicted methyltransferase [General function prediction only]; Region: COG3897 698761007210 Predicted transcriptional regulator [Transcription]; Region: COG2932 698761007211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761007212 non-specific DNA binding site [nucleotide binding]; other site 698761007213 salt bridge; other site 698761007214 sequence-specific DNA binding site [nucleotide binding]; other site 698761007215 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698761007216 Catalytic site [active] 698761007217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 698761007218 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 698761007219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761007220 active site 698761007221 phosphorylation site [posttranslational modification] 698761007222 intermolecular recognition site; other site 698761007223 dimerization interface [polypeptide binding]; other site 698761007224 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761007225 DNA binding residues [nucleotide binding] 698761007226 dimerization interface [polypeptide binding]; other site 698761007227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761007228 ATP binding site [chemical binding]; other site 698761007229 Mg2+ binding site [ion binding]; other site 698761007230 G-X-G motif; other site 698761007231 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761007232 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761007233 Walker A/P-loop; other site 698761007234 ATP binding site [chemical binding]; other site 698761007235 Q-loop/lid; other site 698761007236 ABC transporter signature motif; other site 698761007237 Walker B; other site 698761007238 D-loop; other site 698761007239 H-loop/switch region; other site 698761007240 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 698761007241 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 698761007242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007243 dimer interface [polypeptide binding]; other site 698761007244 conserved gate region; other site 698761007245 putative PBP binding loops; other site 698761007246 ABC-ATPase subunit interface; other site 698761007247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007248 dimer interface [polypeptide binding]; other site 698761007249 conserved gate region; other site 698761007250 putative PBP binding loops; other site 698761007251 ABC-ATPase subunit interface; other site 698761007252 Predicted integral membrane protein [Function unknown]; Region: COG5616 698761007253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761007254 binding surface 698761007255 TPR motif; other site 698761007256 RNA polymerase sigma factor; Provisional; Region: PRK12547 698761007257 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761007258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761007259 DNA binding residues [nucleotide binding] 698761007260 cheY-homologous receiver domain; Region: REC; smart00448 698761007261 active site 698761007262 phosphorylation site [posttranslational modification] 698761007263 intermolecular recognition site; other site 698761007264 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761007265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698761007266 ligand binding site [chemical binding]; other site 698761007267 flexible hinge region; other site 698761007268 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 698761007269 HD domain; Region: HD_4; pfam13328 698761007270 short chain dehydrogenase; Provisional; Region: PRK06701 698761007271 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 698761007272 NAD binding site [chemical binding]; other site 698761007273 metal binding site [ion binding]; metal-binding site 698761007274 active site 698761007275 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 698761007276 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 698761007277 active site 698761007278 DNA binding site [nucleotide binding] 698761007279 Int/Topo IB signature motif; other site 698761007280 catalytic residues [active] 698761007281 thiamine pyrophosphate protein; Provisional; Region: PRK08273 698761007282 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698761007283 PYR/PP interface [polypeptide binding]; other site 698761007284 dimer interface [polypeptide binding]; other site 698761007285 tetramer interface [polypeptide binding]; other site 698761007286 TPP binding site [chemical binding]; other site 698761007287 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698761007288 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698761007289 TPP-binding site [chemical binding]; other site 698761007290 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 698761007291 trehalose synthase; Region: treS_nterm; TIGR02456 698761007292 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 698761007293 active site 698761007294 catalytic site [active] 698761007295 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761007296 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 698761007297 dimerization interface [polypeptide binding]; other site 698761007298 metal binding site [ion binding]; metal-binding site 698761007299 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 698761007300 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 698761007301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761007302 Transposase; Region: HTH_Tnp_1; pfam01527 698761007303 putative transposase OrfB; Reviewed; Region: PHA02517 698761007304 HTH-like domain; Region: HTH_21; pfam13276 698761007305 Integrase core domain; Region: rve; pfam00665 698761007306 Integrase core domain; Region: rve_2; pfam13333 698761007307 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698761007308 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 698761007309 Phage protein D [General function prediction only]; Region: COG3500 698761007310 Phage protein U [General function prediction only]; Region: COG3499 698761007311 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 698761007312 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 698761007313 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 698761007314 Phage tail tube protein FII; Region: Phage_tube; pfam04985 698761007315 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 698761007316 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 698761007317 Phage tail repeat like; Region: PTR; pfam12789 698761007318 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 698761007319 Baseplate J-like protein; Region: Baseplate_J; cl01294 698761007320 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 698761007321 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 698761007322 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 698761007323 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 698761007324 Clp protease; Region: CLP_protease; pfam00574 698761007325 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 698761007326 oligomer interface [polypeptide binding]; other site 698761007327 active site residues [active] 698761007328 3-oxoacyl-acyl-carrier-protein synthase 3; Provisional; Region: fabH; CHL00203 698761007329 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 698761007330 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 698761007331 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 698761007332 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 698761007333 Transcription antiterminator [Transcription]; Region: NusG; COG0250 698761007334 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 698761007335 Helix-turn-helix domain; Region: HTH_36; pfam13730 698761007336 Methyltransferase domain; Region: Methyltransf_26; pfam13659 698761007337 conjugal transfer protein TrbA; Provisional; Region: PRK13890 698761007338 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 698761007339 active site 698761007340 catalytic residues [active] 698761007341 DNA binding site [nucleotide binding] 698761007342 Int/Topo IB signature motif; other site 698761007343 Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]; Region: CDC39; COG5103 698761007344 Uncharacterized conserved protein [Function unknown]; Region: COG2968 698761007345 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 698761007346 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 698761007347 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 698761007348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761007349 Coenzyme A binding pocket [chemical binding]; other site 698761007350 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761007351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761007352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761007353 dimerization interface [polypeptide binding]; other site 698761007354 H+ Antiporter protein; Region: 2A0121; TIGR00900 698761007355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761007356 putative substrate translocation pore; other site 698761007357 B3/4 domain; Region: B3_4; pfam03483 698761007358 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761007359 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761007360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761007361 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761007362 EamA-like transporter family; Region: EamA; cl17759 698761007363 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 698761007364 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 698761007365 active site 698761007366 ATP binding site [chemical binding]; other site 698761007367 Phosphotransferase enzyme family; Region: APH; pfam01636 698761007368 antibiotic binding site [chemical binding]; other site 698761007369 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 698761007370 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 698761007371 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698761007372 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 698761007373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761007374 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698761007375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761007376 DNA binding residues [nucleotide binding] 698761007377 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 698761007378 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698761007379 NAD(P) binding site [chemical binding]; other site 698761007380 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698761007381 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 698761007382 substrate-cofactor binding pocket; other site 698761007383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761007384 catalytic residue [active] 698761007385 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 698761007386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761007387 NAD(P) binding site [chemical binding]; other site 698761007388 active site 698761007389 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 698761007390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698761007391 ATP binding site [chemical binding]; other site 698761007392 putative Mg++ binding site [ion binding]; other site 698761007393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761007394 nucleotide binding region [chemical binding]; other site 698761007395 ATP-binding site [chemical binding]; other site 698761007396 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 698761007397 HRDC domain; Region: HRDC; pfam00570 698761007398 DNA primase; Validated; Region: dnaG; PRK05667 698761007399 CHC2 zinc finger; Region: zf-CHC2; cl17510 698761007400 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698761007401 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698761007402 active site 698761007403 metal binding site [ion binding]; metal-binding site 698761007404 interdomain interaction site; other site 698761007405 Uncharacterized conserved protein [Function unknown]; Region: COG1610 698761007406 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698761007407 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 698761007408 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698761007409 catalytic site [active] 698761007410 subunit interface [polypeptide binding]; other site 698761007411 EVE domain; Region: EVE; cl00728 698761007412 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 698761007413 putative efflux protein, MATE family; Region: matE; TIGR00797 698761007414 cation binding site [ion binding]; other site 698761007415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761007416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761007417 putative substrate translocation pore; other site 698761007418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761007419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761007420 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698761007421 putative effector binding pocket; other site 698761007422 putative dimerization interface [polypeptide binding]; other site 698761007423 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761007424 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761007425 active site 698761007426 catalytic tetrad [active] 698761007427 Predicted metalloprotease [General function prediction only]; Region: COG2321 698761007428 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 698761007429 Predicted membrane protein [Function unknown]; Region: COG5395 698761007430 LytTr DNA-binding domain; Region: LytTR; smart00850 698761007431 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698761007432 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698761007433 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698761007434 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698761007435 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698761007436 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698761007437 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698761007438 IMP binding site; other site 698761007439 dimer interface [polypeptide binding]; other site 698761007440 partial ornithine binding site; other site 698761007441 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698761007442 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698761007443 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698761007444 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698761007445 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761007446 Glycosyltransferase family 92; Region: Glyco_transf_92; pfam01697 698761007447 active site 698761007448 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761007449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761007450 putative DNA binding site [nucleotide binding]; other site 698761007451 putative Zn2+ binding site [ion binding]; other site 698761007452 AsnC family; Region: AsnC_trans_reg; pfam01037 698761007453 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698761007454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761007455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761007456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761007457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761007458 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761007459 putative effector binding pocket; other site 698761007460 dimerization interface [polypeptide binding]; other site 698761007461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761007462 dimerization interface [polypeptide binding]; other site 698761007463 putative DNA binding site [nucleotide binding]; other site 698761007464 putative Zn2+ binding site [ion binding]; other site 698761007465 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698761007466 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698761007467 FMN binding site [chemical binding]; other site 698761007468 active site 698761007469 substrate binding site [chemical binding]; other site 698761007470 catalytic residue [active] 698761007471 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761007472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761007473 NAD(P) binding site [chemical binding]; other site 698761007474 active site 698761007475 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761007476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761007477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761007478 dimerization interface [polypeptide binding]; other site 698761007479 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 698761007480 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 698761007481 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 698761007482 aspartate aminotransferase; Provisional; Region: PRK05764 698761007483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761007484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761007485 homodimer interface [polypeptide binding]; other site 698761007486 catalytic residue [active] 698761007487 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 698761007488 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 698761007489 EamA-like transporter family; Region: EamA; pfam00892 698761007490 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698761007491 DNA-binding site [nucleotide binding]; DNA binding site 698761007492 RNA-binding motif; other site 698761007493 BA14K-like protein; Region: BA14K; pfam07886 698761007494 AAA domain; Region: AAA_17; pfam13207 698761007495 AAA domain; Region: AAA_33; pfam13671 698761007496 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698761007497 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 698761007498 Bacterial SH3 domain; Region: SH3_3; pfam08239 698761007499 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698761007500 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761007501 MarR family; Region: MarR_2; pfam12802 698761007502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761007503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761007504 active site 698761007505 phosphorylation site [posttranslational modification] 698761007506 intermolecular recognition site; other site 698761007507 dimerization interface [polypeptide binding]; other site 698761007508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761007509 DNA binding site [nucleotide binding] 698761007510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761007511 HAMP domain; Region: HAMP; pfam00672 698761007512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761007513 ATP binding site [chemical binding]; other site 698761007514 Mg2+ binding site [ion binding]; other site 698761007515 G-X-G motif; other site 698761007516 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 698761007517 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 698761007518 dimer interface [polypeptide binding]; other site 698761007519 putative tRNA-binding site [nucleotide binding]; other site 698761007520 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698761007521 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698761007522 Uncharacterized conserved protein [Function unknown]; Region: COG5465 698761007523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 698761007524 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 698761007525 Uncharacterized conserved protein [Function unknown]; Region: COG1565 698761007526 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698761007527 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698761007528 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698761007529 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761007530 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698761007531 active site 698761007532 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 698761007533 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698761007534 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761007535 active site 698761007536 H+ Antiporter protein; Region: 2A0121; TIGR00900 698761007537 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698761007538 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698761007539 5S rRNA interface [nucleotide binding]; other site 698761007540 CTC domain interface [polypeptide binding]; other site 698761007541 L16 interface [polypeptide binding]; other site 698761007542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761007543 dimerization interface [polypeptide binding]; other site 698761007544 PAS domain S-box; Region: sensory_box; TIGR00229 698761007545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761007546 putative active site [active] 698761007547 heme pocket [chemical binding]; other site 698761007548 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761007549 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761007550 metal binding site [ion binding]; metal-binding site 698761007551 active site 698761007552 I-site; other site 698761007553 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761007554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761007555 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761007556 substrate binding pocket [chemical binding]; other site 698761007557 membrane-bound complex binding site; other site 698761007558 hinge residues; other site 698761007559 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698761007560 putative active site [active] 698761007561 catalytic residue [active] 698761007562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761007563 Coenzyme A binding pocket [chemical binding]; other site 698761007564 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 698761007565 GTP-binding protein YchF; Reviewed; Region: PRK09601 698761007566 YchF GTPase; Region: YchF; cd01900 698761007567 G1 box; other site 698761007568 GTP/Mg2+ binding site [chemical binding]; other site 698761007569 Switch I region; other site 698761007570 G2 box; other site 698761007571 Switch II region; other site 698761007572 G3 box; other site 698761007573 G4 box; other site 698761007574 G5 box; other site 698761007575 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698761007576 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 698761007577 putative active site [active] 698761007578 putative catalytic site [active] 698761007579 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 698761007580 putative active site [active] 698761007581 putative catalytic site [active] 698761007582 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761007583 active site 698761007584 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 698761007585 cytochrome b; Provisional; Region: CYTB; MTH00119 698761007586 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 698761007587 Qi binding site; other site 698761007588 intrachain domain interface; other site 698761007589 interchain domain interface [polypeptide binding]; other site 698761007590 heme bH binding site [chemical binding]; other site 698761007591 heme bL binding site [chemical binding]; other site 698761007592 Qo binding site; other site 698761007593 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 698761007594 interchain domain interface [polypeptide binding]; other site 698761007595 intrachain domain interface; other site 698761007596 Qi binding site; other site 698761007597 Qo binding site; other site 698761007598 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 698761007599 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 698761007600 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 698761007601 [2Fe-2S] cluster binding site [ion binding]; other site 698761007602 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761007603 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761007604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761007605 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 698761007606 Walker A/P-loop; other site 698761007607 ATP binding site [chemical binding]; other site 698761007608 Q-loop/lid; other site 698761007609 ABC transporter signature motif; other site 698761007610 Walker B; other site 698761007611 D-loop; other site 698761007612 H-loop/switch region; other site 698761007613 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698761007614 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 698761007615 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 698761007616 Predicted small metal-binding protein [Function unknown]; Region: COG5466 698761007617 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 698761007618 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698761007619 active site 698761007620 NTP binding site [chemical binding]; other site 698761007621 metal binding triad [ion binding]; metal-binding site 698761007622 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698761007623 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698761007624 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698761007625 putative active site [active] 698761007626 putative CoA binding site [chemical binding]; other site 698761007627 nudix motif; other site 698761007628 metal binding site [ion binding]; metal-binding site 698761007629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 698761007630 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 698761007631 MoxR-like ATPases [General function prediction only]; Region: COG0714 698761007632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 698761007633 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 698761007634 Protein of unknown function DUF58; Region: DUF58; pfam01882 698761007635 Aerotolerance regulator N-terminal; Region: BatA; cl06567 698761007636 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 698761007637 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 698761007638 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 698761007639 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761007640 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698761007641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761007642 Coenzyme A binding pocket [chemical binding]; other site 698761007643 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698761007644 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 698761007645 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698761007646 putative dimer interface [polypeptide binding]; other site 698761007647 N-terminal domain interface [polypeptide binding]; other site 698761007648 putative substrate binding pocket (H-site) [chemical binding]; other site 698761007649 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 698761007650 nudix motif; other site 698761007651 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761007652 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 698761007653 putative active site [active] 698761007654 putative metal binding site [ion binding]; other site 698761007655 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698761007656 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698761007657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761007658 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698761007659 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698761007660 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761007661 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761007662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761007663 Walker A/P-loop; other site 698761007664 ATP binding site [chemical binding]; other site 698761007665 Q-loop/lid; other site 698761007666 ABC transporter signature motif; other site 698761007667 Walker B; other site 698761007668 D-loop; other site 698761007669 H-loop/switch region; other site 698761007670 2-isopropylmalate synthase; Validated; Region: PRK03739 698761007671 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698761007672 active site 698761007673 catalytic residues [active] 698761007674 metal binding site [ion binding]; metal-binding site 698761007675 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 698761007676 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 698761007677 benzoate transporter; Region: benE; TIGR00843 698761007678 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761007679 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761007680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761007681 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761007682 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698761007683 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761007684 active site 698761007685 metal binding site [ion binding]; metal-binding site 698761007686 Clp protease; Region: CLP_protease; pfam00574 698761007687 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698761007688 oligomer interface [polypeptide binding]; other site 698761007689 active site residues [active] 698761007690 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 698761007691 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 698761007692 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698761007693 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 698761007694 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 698761007695 putative FMN binding site [chemical binding]; other site 698761007696 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 698761007697 dimer interface [polypeptide binding]; other site 698761007698 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761007699 ligand binding site [chemical binding]; other site 698761007700 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 698761007701 anthranilate synthase; Provisional; Region: PRK13566 698761007702 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698761007703 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698761007704 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698761007705 glutamine binding [chemical binding]; other site 698761007706 catalytic triad [active] 698761007707 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698761007708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761007709 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761007710 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 698761007711 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698761007712 N-terminal plug; other site 698761007713 ligand-binding site [chemical binding]; other site 698761007714 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 698761007715 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 698761007716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761007717 S-adenosylmethionine binding site [chemical binding]; other site 698761007718 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698761007719 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698761007720 Potassium binding sites [ion binding]; other site 698761007721 Cesium cation binding sites [ion binding]; other site 698761007722 hypothetical protein; Provisional; Region: PRK05208 698761007723 Predicted periplasmic protein [Function unknown]; Region: COG3904 698761007724 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698761007725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761007726 DNA binding residues [nucleotide binding] 698761007727 dimerization interface [polypeptide binding]; other site 698761007728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 698761007729 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 698761007730 Cytochrome c2 [Energy production and conversion]; Region: COG3474 698761007731 thymidine kinase; Provisional; Region: PRK04296 698761007732 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 698761007733 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 698761007734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007735 dimer interface [polypeptide binding]; other site 698761007736 conserved gate region; other site 698761007737 putative PBP binding loops; other site 698761007738 ABC-ATPase subunit interface; other site 698761007739 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 698761007740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761007741 Walker A/P-loop; other site 698761007742 ATP binding site [chemical binding]; other site 698761007743 Q-loop/lid; other site 698761007744 ABC transporter signature motif; other site 698761007745 Walker B; other site 698761007746 D-loop; other site 698761007747 H-loop/switch region; other site 698761007748 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 698761007749 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 698761007750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761007751 dimerization interface [polypeptide binding]; other site 698761007752 putative DNA binding site [nucleotide binding]; other site 698761007753 putative Zn2+ binding site [ion binding]; other site 698761007754 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 698761007755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761007756 inhibitor-cofactor binding pocket; inhibition site 698761007757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761007758 catalytic residue [active] 698761007759 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 698761007760 putative active site [active] 698761007761 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 698761007762 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761007763 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 698761007764 active site 698761007765 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 698761007766 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 698761007767 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698761007768 active site 698761007769 catalytic site [active] 698761007770 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 698761007771 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 698761007772 peptide binding site [polypeptide binding]; other site 698761007773 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 698761007774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007775 dimer interface [polypeptide binding]; other site 698761007776 conserved gate region; other site 698761007777 putative PBP binding loops; other site 698761007778 ABC-ATPase subunit interface; other site 698761007779 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 698761007780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761007781 dimer interface [polypeptide binding]; other site 698761007782 conserved gate region; other site 698761007783 putative PBP binding loops; other site 698761007784 ABC-ATPase subunit interface; other site 698761007785 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698761007786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761007787 Walker A/P-loop; other site 698761007788 ATP binding site [chemical binding]; other site 698761007789 Q-loop/lid; other site 698761007790 ABC transporter signature motif; other site 698761007791 Walker B; other site 698761007792 D-loop; other site 698761007793 H-loop/switch region; other site 698761007794 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761007795 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 698761007796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761007797 Walker A/P-loop; other site 698761007798 ATP binding site [chemical binding]; other site 698761007799 Q-loop/lid; other site 698761007800 ABC transporter signature motif; other site 698761007801 Walker B; other site 698761007802 D-loop; other site 698761007803 H-loop/switch region; other site 698761007804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761007805 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761007806 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698761007807 substrate binding site [chemical binding]; other site 698761007808 ATP binding site [chemical binding]; other site 698761007809 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698761007810 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761007811 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 698761007812 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761007813 MarR family; Region: MarR; pfam01047 698761007814 GTP-binding protein Der; Reviewed; Region: PRK00093 698761007815 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698761007816 G1 box; other site 698761007817 GTP/Mg2+ binding site [chemical binding]; other site 698761007818 Switch I region; other site 698761007819 G2 box; other site 698761007820 Switch II region; other site 698761007821 G3 box; other site 698761007822 G4 box; other site 698761007823 G5 box; other site 698761007824 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698761007825 G1 box; other site 698761007826 GTP/Mg2+ binding site [chemical binding]; other site 698761007827 Switch I region; other site 698761007828 G2 box; other site 698761007829 G3 box; other site 698761007830 Switch II region; other site 698761007831 G4 box; other site 698761007832 G5 box; other site 698761007833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 698761007834 NnrU protein; Region: NnrU; pfam07298 698761007835 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 698761007836 NodB motif; other site 698761007837 putative active site [active] 698761007838 putative catalytic site [active] 698761007839 microcin B17 transporter; Reviewed; Region: PRK11098 698761007840 Predicted transcriptional regulators [Transcription]; Region: COG1695 698761007841 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 698761007842 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698761007843 active site 698761007844 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761007845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761007846 DoxX-like family; Region: DoxX_2; pfam13564 698761007847 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 698761007848 putative hydrophobic ligand binding site [chemical binding]; other site 698761007849 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 698761007850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761007851 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698761007852 DNA binding residues [nucleotide binding] 698761007853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 698761007854 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 698761007855 dimer interface [polypeptide binding]; other site 698761007856 catalytic triad [active] 698761007857 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 698761007858 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 698761007859 N- and C-terminal domain interface [polypeptide binding]; other site 698761007860 active site 698761007861 MgATP binding site [chemical binding]; other site 698761007862 catalytic site [active] 698761007863 metal binding site [ion binding]; metal-binding site 698761007864 glycerol binding site [chemical binding]; other site 698761007865 homotetramer interface [polypeptide binding]; other site 698761007866 homodimer interface [polypeptide binding]; other site 698761007867 FBP binding site [chemical binding]; other site 698761007868 protein IIAGlc interface [polypeptide binding]; other site 698761007869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761007870 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 698761007871 NAD(P) binding site [chemical binding]; other site 698761007872 active site 698761007873 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 698761007874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761007875 catalytic loop [active] 698761007876 iron binding site [ion binding]; other site 698761007877 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698761007878 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 698761007879 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 698761007880 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698761007881 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761007882 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761007883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761007884 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698761007885 dimerization interface [polypeptide binding]; other site 698761007886 substrate binding pocket [chemical binding]; other site 698761007887 Predicted membrane protein [Function unknown]; Region: COG3748 698761007888 Protein of unknown function (DUF989); Region: DUF989; pfam06181 698761007889 Cytochrome c; Region: Cytochrom_C; pfam00034 698761007890 guanine deaminase; Provisional; Region: PRK09228 698761007891 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 698761007892 active site 698761007893 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698761007894 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 698761007895 phosphate binding site [ion binding]; other site 698761007896 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 698761007897 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 698761007898 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 698761007899 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761007900 active site 698761007901 metal binding site [ion binding]; metal-binding site 698761007902 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 698761007903 active site 698761007904 homotetramer interface [polypeptide binding]; other site 698761007905 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 698761007906 ureidoglycolate hydrolase; Provisional; Region: PRK03606 698761007907 Protein of unknown function DUF86; Region: DUF86; cl01031 698761007908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 698761007909 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 698761007910 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 698761007911 active site 698761007912 catalytic site [active] 698761007913 tetramer interface [polypeptide binding]; other site 698761007914 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 698761007915 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761007916 Uncharacterized conserved protein [Function unknown]; Region: COG4121 698761007917 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698761007918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761007919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761007920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761007921 short chain dehydrogenase; Provisional; Region: PRK06180 698761007922 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761007923 NADP binding site [chemical binding]; other site 698761007924 active site 698761007925 steroid binding site; other site 698761007926 PAS domain; Region: PAS; smart00091 698761007927 PAS fold; Region: PAS_7; pfam12860 698761007928 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698761007929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761007930 dimer interface [polypeptide binding]; other site 698761007931 phosphorylation site [posttranslational modification] 698761007932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761007933 ATP binding site [chemical binding]; other site 698761007934 Mg2+ binding site [ion binding]; other site 698761007935 G-X-G motif; other site 698761007936 Response regulator receiver domain; Region: Response_reg; pfam00072 698761007937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761007938 active site 698761007939 phosphorylation site [posttranslational modification] 698761007940 intermolecular recognition site; other site 698761007941 dimerization interface [polypeptide binding]; other site 698761007942 Response regulator receiver domain; Region: Response_reg; pfam00072 698761007943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761007944 active site 698761007945 phosphorylation site [posttranslational modification] 698761007946 intermolecular recognition site; other site 698761007947 dimerization interface [polypeptide binding]; other site 698761007948 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 698761007949 helicase 45; Provisional; Region: PTZ00424 698761007950 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698761007951 ATP binding site [chemical binding]; other site 698761007952 Mg++ binding site [ion binding]; other site 698761007953 motif III; other site 698761007954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761007955 nucleotide binding region [chemical binding]; other site 698761007956 ATP-binding site [chemical binding]; other site 698761007957 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 698761007958 EamA-like transporter family; Region: EamA; pfam00892 698761007959 EamA-like transporter family; Region: EamA; pfam00892 698761007960 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761007961 EamA-like transporter family; Region: EamA; pfam00892 698761007962 EamA-like transporter family; Region: EamA; pfam00892 698761007963 Uncharacterized conserved protein [Function unknown]; Region: COG2308 698761007964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 698761007965 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 698761007966 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 698761007967 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 698761007968 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 698761007969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761007970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761007971 short chain dehydrogenase; Provisional; Region: PRK06500 698761007972 classical (c) SDRs; Region: SDR_c; cd05233 698761007973 NAD(P) binding site [chemical binding]; other site 698761007974 active site 698761007975 dihydroxy-acid dehydratase; Validated; Region: PRK06131 698761007976 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 698761007977 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761007978 NAD(P) binding site [chemical binding]; other site 698761007979 catalytic residues [active] 698761007980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 698761007981 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 698761007982 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761007983 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761007984 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761007985 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761007986 TM-ABC transporter signature motif; other site 698761007987 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761007988 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761007989 Walker A/P-loop; other site 698761007990 ATP binding site [chemical binding]; other site 698761007991 Q-loop/lid; other site 698761007992 ABC transporter signature motif; other site 698761007993 Walker B; other site 698761007994 D-loop; other site 698761007995 H-loop/switch region; other site 698761007996 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761007997 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 698761007998 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 698761007999 putative ligand binding site [chemical binding]; other site 698761008000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761008001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761008002 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 698761008003 putative dimerization interface [polypeptide binding]; other site 698761008004 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761008005 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761008006 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761008007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761008008 dimerization interface [polypeptide binding]; other site 698761008009 putative DNA binding site [nucleotide binding]; other site 698761008010 putative Zn2+ binding site [ion binding]; other site 698761008011 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698761008012 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 698761008013 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698761008014 oligomer interface [polypeptide binding]; other site 698761008015 active site residues [active] 698761008016 MarR family; Region: MarR_2; pfam12802 698761008017 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761008018 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761008019 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 698761008020 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 698761008021 putative ligand binding site [chemical binding]; other site 698761008022 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761008023 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761008024 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761008025 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761008026 TM-ABC transporter signature motif; other site 698761008027 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761008028 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761008029 Walker A/P-loop; other site 698761008030 ATP binding site [chemical binding]; other site 698761008031 Q-loop/lid; other site 698761008032 ABC transporter signature motif; other site 698761008033 Walker B; other site 698761008034 D-loop; other site 698761008035 H-loop/switch region; other site 698761008036 Porin subfamily; Region: Porin_2; pfam02530 698761008037 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 698761008038 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761008039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761008040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761008041 Coenzyme A binding pocket [chemical binding]; other site 698761008042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761008043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761008044 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 698761008045 putative substrate binding pocket [chemical binding]; other site 698761008046 putative dimerization interface [polypeptide binding]; other site 698761008047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761008048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761008049 putative substrate translocation pore; other site 698761008050 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 698761008051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761008052 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698761008053 DNA binding residues [nucleotide binding] 698761008054 Tetratricopeptide repeat; Region: TPR_2; pfam07719 698761008055 YCII-related domain; Region: YCII; cl00999 698761008056 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 698761008057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761008058 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 698761008059 active site 698761008060 Response regulator receiver domain; Region: Response_reg; pfam00072 698761008061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761008062 active site 698761008063 phosphorylation site [posttranslational modification] 698761008064 intermolecular recognition site; other site 698761008065 dimerization interface [polypeptide binding]; other site 698761008066 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 698761008067 putative metal dependent hydrolase; Provisional; Region: PRK11598 698761008068 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 698761008069 Sulfatase; Region: Sulfatase; pfam00884 698761008070 Cupin domain; Region: Cupin_2; cl17218 698761008071 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698761008072 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 698761008073 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698761008074 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698761008075 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698761008076 putative active site [active] 698761008077 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 698761008078 Predicted membrane protein [Function unknown]; Region: COG4280 698761008079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698761008080 catalytic core [active] 698761008081 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 698761008082 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761008083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761008084 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698761008085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761008086 DNA-binding site [nucleotide binding]; DNA binding site 698761008087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761008088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761008089 homodimer interface [polypeptide binding]; other site 698761008090 catalytic residue [active] 698761008091 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 698761008092 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698761008093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761008094 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 698761008095 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 698761008096 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698761008097 tetramer interface [polypeptide binding]; other site 698761008098 TPP-binding site [chemical binding]; other site 698761008099 heterodimer interface [polypeptide binding]; other site 698761008100 phosphorylation loop region [posttranslational modification] 698761008101 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698761008102 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698761008103 alpha subunit interface [polypeptide binding]; other site 698761008104 TPP binding site [chemical binding]; other site 698761008105 heterodimer interface [polypeptide binding]; other site 698761008106 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698761008107 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698761008108 carboxyltransferase (CT) interaction site; other site 698761008109 biotinylation site [posttranslational modification]; other site 698761008110 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 698761008111 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698761008112 dimer interface [polypeptide binding]; other site 698761008113 active site 698761008114 CoA binding pocket [chemical binding]; other site 698761008115 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 698761008116 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 698761008117 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 698761008118 putative Cl- selectivity filter; other site 698761008119 putative pore gating glutamate residue; other site 698761008120 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698761008121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761008122 S-adenosylmethionine binding site [chemical binding]; other site 698761008123 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761008124 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761008125 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761008126 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 698761008127 conserved cys residue [active] 698761008128 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698761008129 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 698761008130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761008131 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761008132 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761008133 Walker A/P-loop; other site 698761008134 ATP binding site [chemical binding]; other site 698761008135 Q-loop/lid; other site 698761008136 ABC transporter signature motif; other site 698761008137 Walker B; other site 698761008138 D-loop; other site 698761008139 H-loop/switch region; other site 698761008140 TOBE domain; Region: TOBE_2; pfam08402 698761008141 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761008142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761008143 dimer interface [polypeptide binding]; other site 698761008144 conserved gate region; other site 698761008145 putative PBP binding loops; other site 698761008146 ABC-ATPase subunit interface; other site 698761008147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761008148 dimer interface [polypeptide binding]; other site 698761008149 conserved gate region; other site 698761008150 putative PBP binding loops; other site 698761008151 ABC-ATPase subunit interface; other site 698761008152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761008153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761008154 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761008155 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761008156 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761008157 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761008158 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761008159 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761008160 DNA binding site [nucleotide binding] 698761008161 domain linker motif; other site 698761008162 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698761008163 ligand binding site [chemical binding]; other site 698761008164 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698761008165 apolar tunnel; other site 698761008166 heme binding site [chemical binding]; other site 698761008167 dimerization interface [polypeptide binding]; other site 698761008168 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698761008169 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 698761008170 TolA protein; Region: tolA_full; TIGR02794 698761008171 TonB C terminal; Region: TonB_2; pfam13103 698761008172 Hemin uptake protein hemP; Region: hemP; cl10043 698761008173 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 698761008174 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 698761008175 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 698761008176 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 698761008177 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 698761008178 putative hemin binding site; other site 698761008179 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698761008180 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698761008181 ABC-ATPase subunit interface; other site 698761008182 dimer interface [polypeptide binding]; other site 698761008183 putative PBP binding regions; other site 698761008184 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 698761008185 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698761008186 Walker A/P-loop; other site 698761008187 ATP binding site [chemical binding]; other site 698761008188 Q-loop/lid; other site 698761008189 ABC transporter signature motif; other site 698761008190 Walker B; other site 698761008191 D-loop; other site 698761008192 H-loop/switch region; other site 698761008193 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 698761008194 RNA polymerase sigma factor; Provisional; Region: PRK12516 698761008195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761008196 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761008197 DNA binding residues [nucleotide binding] 698761008198 two-component response regulator; Provisional; Region: PRK09191 698761008199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 698761008200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761008201 active site 698761008202 phosphorylation site [posttranslational modification] 698761008203 intermolecular recognition site; other site 698761008204 dimerization interface [polypeptide binding]; other site 698761008205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698761008206 HWE histidine kinase; Region: HWE_HK; pfam07536 698761008207 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 698761008208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761008209 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 698761008210 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 698761008211 homodimer interface [polypeptide binding]; other site 698761008212 active site 698761008213 FMN binding site [chemical binding]; other site 698761008214 substrate binding site [chemical binding]; other site 698761008215 4Fe-4S binding domain; Region: Fer4_6; pfam12837 698761008216 4Fe-4S binding domain; Region: Fer4; pfam00037 698761008217 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 698761008218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761008219 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 698761008220 allantoate amidohydrolase; Reviewed; Region: PRK12893 698761008221 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 698761008222 active site 698761008223 metal binding site [ion binding]; metal-binding site 698761008224 dimer interface [polypeptide binding]; other site 698761008225 phenylhydantoinase; Validated; Region: PRK08323 698761008226 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 698761008227 tetramer interface [polypeptide binding]; other site 698761008228 active site 698761008229 Predicted mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: COG4101 698761008230 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761008231 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761008232 Walker A/P-loop; other site 698761008233 ATP binding site [chemical binding]; other site 698761008234 Q-loop/lid; other site 698761008235 ABC transporter signature motif; other site 698761008236 Walker B; other site 698761008237 D-loop; other site 698761008238 H-loop/switch region; other site 698761008239 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761008240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761008241 dimer interface [polypeptide binding]; other site 698761008242 conserved gate region; other site 698761008243 putative PBP binding loops; other site 698761008244 ABC-ATPase subunit interface; other site 698761008245 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761008246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761008247 dimer interface [polypeptide binding]; other site 698761008248 conserved gate region; other site 698761008249 putative PBP binding loops; other site 698761008250 ABC-ATPase subunit interface; other site 698761008251 NMT1/THI5 like; Region: NMT1; pfam09084 698761008252 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761008253 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761008254 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761008255 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698761008256 Protein export membrane protein; Region: SecD_SecF; cl14618 698761008257 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698761008258 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 698761008259 UreF; Region: UreF; pfam01730 698761008260 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 698761008261 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 698761008262 dimer interface [polypeptide binding]; other site 698761008263 catalytic residues [active] 698761008264 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761008265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761008266 metal binding site [ion binding]; metal-binding site 698761008267 active site 698761008268 I-site; other site 698761008269 urease subunit alpha; Reviewed; Region: ureC; PRK13207 698761008270 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 698761008271 subunit interactions [polypeptide binding]; other site 698761008272 active site 698761008273 flap region; other site 698761008274 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 698761008275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 698761008276 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 698761008277 gamma-beta subunit interface [polypeptide binding]; other site 698761008278 alpha-beta subunit interface [polypeptide binding]; other site 698761008279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 698761008280 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 698761008281 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 698761008282 alpha-gamma subunit interface [polypeptide binding]; other site 698761008283 beta-gamma subunit interface [polypeptide binding]; other site 698761008284 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 698761008285 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698761008286 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 698761008287 dimerization interface [polypeptide binding]; other site 698761008288 ligand binding site [chemical binding]; other site 698761008289 NADP binding site [chemical binding]; other site 698761008290 catalytic site [active] 698761008291 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698761008292 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 698761008293 dimerization interface [polypeptide binding]; other site 698761008294 ligand binding site [chemical binding]; other site 698761008295 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698761008296 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698761008297 Walker A/P-loop; other site 698761008298 ATP binding site [chemical binding]; other site 698761008299 Q-loop/lid; other site 698761008300 ABC transporter signature motif; other site 698761008301 Walker B; other site 698761008302 D-loop; other site 698761008303 H-loop/switch region; other site 698761008304 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761008305 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698761008306 Walker A/P-loop; other site 698761008307 ATP binding site [chemical binding]; other site 698761008308 Q-loop/lid; other site 698761008309 ABC transporter signature motif; other site 698761008310 Walker B; other site 698761008311 D-loop; other site 698761008312 H-loop/switch region; other site 698761008313 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 698761008314 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698761008315 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698761008316 TM-ABC transporter signature motif; other site 698761008317 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761008318 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698761008319 TM-ABC transporter signature motif; other site 698761008320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761008321 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761008322 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761008323 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761008324 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761008325 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698761008326 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698761008327 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 698761008328 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761008329 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 698761008330 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 698761008331 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698761008332 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761008333 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 698761008334 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 698761008335 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761008336 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 698761008337 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698761008338 active site 698761008339 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 698761008340 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698761008341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761008342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761008343 active site 698761008344 phosphorylation site [posttranslational modification] 698761008345 intermolecular recognition site; other site 698761008346 dimerization interface [polypeptide binding]; other site 698761008347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761008348 DNA binding site [nucleotide binding] 698761008349 Transposase IS200 like; Region: Y1_Tnp; pfam01797 698761008350 Response regulator receiver domain; Region: Response_reg; pfam00072 698761008351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761008352 active site 698761008353 phosphorylation site [posttranslational modification] 698761008354 intermolecular recognition site; other site 698761008355 dimerization interface [polypeptide binding]; other site 698761008356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 698761008357 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 698761008358 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698761008359 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698761008360 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698761008361 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698761008362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698761008363 RNA binding surface [nucleotide binding]; other site 698761008364 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698761008365 active site 698761008366 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 698761008367 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698761008368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761008369 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761008370 DNA binding residues [nucleotide binding] 698761008371 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698761008372 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698761008373 GDP-binding site [chemical binding]; other site 698761008374 ACT binding site; other site 698761008375 IMP binding site; other site 698761008376 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761008377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761008378 Coenzyme A binding pocket [chemical binding]; other site 698761008379 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698761008380 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698761008381 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698761008382 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698761008383 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761008384 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 698761008385 putative NAD(P) binding site [chemical binding]; other site 698761008386 active site 698761008387 putative substrate binding site [chemical binding]; other site 698761008388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761008389 Flavin Reductases; Region: FlaRed; cl00801 698761008390 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 698761008391 putative metal binding site [ion binding]; other site 698761008392 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761008393 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698761008394 homotrimer interaction site [polypeptide binding]; other site 698761008395 putative active site [active] 698761008396 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761008397 EamA-like transporter family; Region: EamA; pfam00892 698761008398 EamA-like transporter family; Region: EamA; pfam00892 698761008399 Predicted esterase [General function prediction only]; Region: COG0400 698761008400 Serine hydrolase (FSH1); Region: FSH1; pfam03959 698761008401 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698761008402 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761008403 Zn binding site [ion binding]; other site 698761008404 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698761008405 Zn binding site [ion binding]; other site 698761008406 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 698761008407 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698761008408 oligomeric interface; other site 698761008409 putative active site [active] 698761008410 homodimer interface [polypeptide binding]; other site 698761008411 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698761008412 ligand binding site [chemical binding]; other site 698761008413 active site 698761008414 UGI interface [polypeptide binding]; other site 698761008415 catalytic site [active] 698761008416 topology modulation protein; Provisional; Region: PRK07261 698761008417 AAA domain; Region: AAA_17; pfam13207 698761008418 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761008419 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761008420 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698761008421 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 698761008422 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761008423 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 698761008424 Phosphotransferase enzyme family; Region: APH; pfam01636 698761008425 active site 698761008426 ATP binding site [chemical binding]; other site 698761008427 substrate binding site [chemical binding]; other site 698761008428 dimer interface [polypeptide binding]; other site 698761008429 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761008430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761008431 DNA-binding site [nucleotide binding]; DNA binding site 698761008432 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761008433 Hint domain; Region: Hint_2; pfam13403 698761008434 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 698761008435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761008436 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698761008437 putative dimerization interface [polypeptide binding]; other site 698761008438 Predicted membrane protein [Function unknown]; Region: COG2855 698761008439 PAS fold; Region: PAS_3; pfam08447 698761008440 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761008441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761008442 metal binding site [ion binding]; metal-binding site 698761008443 active site 698761008444 I-site; other site 698761008445 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761008446 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 698761008447 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761008448 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761008449 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 698761008450 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761008451 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761008452 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761008453 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698761008454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761008455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761008456 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 698761008457 putative effector binding pocket; other site 698761008458 putative dimerization interface [polypeptide binding]; other site 698761008459 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698761008460 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698761008461 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 698761008462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761008463 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698761008464 DNA binding residues [nucleotide binding] 698761008465 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761008466 Helix-turn-helix domain; Region: HTH_18; pfam12833 698761008467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761008468 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761008469 EamA-like transporter family; Region: EamA; pfam00892 698761008470 EamA-like transporter family; Region: EamA; pfam00892 698761008471 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761008472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698761008473 FCD domain; Region: FCD; pfam07729 698761008474 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698761008475 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 698761008476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761008477 catalytic residue [active] 698761008478 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 698761008479 aspartate aminotransferase; Provisional; Region: PRK06108 698761008480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761008481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761008482 homodimer interface [polypeptide binding]; other site 698761008483 catalytic residue [active] 698761008484 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761008485 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761008486 substrate binding pocket [chemical binding]; other site 698761008487 membrane-bound complex binding site; other site 698761008488 hinge residues; other site 698761008489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761008490 dimer interface [polypeptide binding]; other site 698761008491 conserved gate region; other site 698761008492 putative PBP binding loops; other site 698761008493 ABC-ATPase subunit interface; other site 698761008494 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761008495 MarR family; Region: MarR; pfam01047 698761008496 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 698761008497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761008498 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 698761008499 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 698761008500 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761008501 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761008502 MarR family; Region: MarR_2; pfam12802 698761008503 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 698761008504 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 698761008505 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 698761008506 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 698761008507 PYR/PP interface [polypeptide binding]; other site 698761008508 dimer interface [polypeptide binding]; other site 698761008509 TPP binding site [chemical binding]; other site 698761008510 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 698761008511 TPP-binding site; other site 698761008512 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761008513 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698761008514 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761008515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698761008516 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698761008517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761008518 dimer interface [polypeptide binding]; other site 698761008519 conserved gate region; other site 698761008520 putative PBP binding loops; other site 698761008521 ABC-ATPase subunit interface; other site 698761008522 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761008523 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698761008524 Walker A/P-loop; other site 698761008525 ATP binding site [chemical binding]; other site 698761008526 Q-loop/lid; other site 698761008527 ABC transporter signature motif; other site 698761008528 Walker B; other site 698761008529 D-loop; other site 698761008530 H-loop/switch region; other site 698761008531 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761008532 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698761008533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761008534 Walker A/P-loop; other site 698761008535 ATP binding site [chemical binding]; other site 698761008536 Q-loop/lid; other site 698761008537 ABC transporter signature motif; other site 698761008538 Walker B; other site 698761008539 D-loop; other site 698761008540 H-loop/switch region; other site 698761008541 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761008542 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761008543 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698761008544 active site 698761008545 metal binding site [ion binding]; metal-binding site 698761008546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698761008547 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 698761008548 acyl-activating enzyme (AAE) consensus motif; other site 698761008549 AMP binding site [chemical binding]; other site 698761008550 active site 698761008551 CoA binding site [chemical binding]; other site 698761008552 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 698761008553 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761008554 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 698761008555 active site 698761008556 FMN binding site [chemical binding]; other site 698761008557 substrate binding site [chemical binding]; other site 698761008558 homotetramer interface [polypeptide binding]; other site 698761008559 catalytic residue [active] 698761008560 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761008561 classical (c) SDRs; Region: SDR_c; cd05233 698761008562 NAD(P) binding site [chemical binding]; other site 698761008563 active site 698761008564 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698761008565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761008566 substrate binding site [chemical binding]; other site 698761008567 oxyanion hole (OAH) forming residues; other site 698761008568 trimer interface [polypeptide binding]; other site 698761008569 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761008570 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761008571 active site 698761008572 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 698761008573 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761008574 FAD binding site [chemical binding]; other site 698761008575 substrate binding pocket [chemical binding]; other site 698761008576 catalytic base [active] 698761008577 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698761008578 active site 698761008579 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698761008580 homotrimer interaction site [polypeptide binding]; other site 698761008581 putative active site [active] 698761008582 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 698761008583 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761008584 substrate binding site [chemical binding]; other site 698761008585 oxyanion hole (OAH) forming residues; other site 698761008586 trimer interface [polypeptide binding]; other site 698761008587 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698761008588 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698761008589 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698761008590 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761008591 cyclase homology domain; Region: CHD; cd07302 698761008592 nucleotidyl binding site; other site 698761008593 metal binding site [ion binding]; metal-binding site 698761008594 dimer interface [polypeptide binding]; other site 698761008595 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761008596 NADP binding site [chemical binding]; other site 698761008597 active site 698761008598 steroid binding site; other site 698761008599 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 698761008600 short chain dehydrogenase; Provisional; Region: PRK12937 698761008601 NADP binding site [chemical binding]; other site 698761008602 homodimer interface [polypeptide binding]; other site 698761008603 active site 698761008604 substrate binding site [chemical binding]; other site 698761008605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761008606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761008607 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 698761008608 putative effector binding pocket; other site 698761008609 putative dimerization interface [polypeptide binding]; other site 698761008610 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698761008611 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698761008612 active site 698761008613 non-prolyl cis peptide bond; other site 698761008614 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 698761008615 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 698761008616 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 698761008617 MOFRL family; Region: MOFRL; pfam05161 698761008618 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 698761008619 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 698761008620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761008621 putative transporter; Provisional; Region: PRK10504 698761008622 putative substrate translocation pore; other site 698761008623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761008624 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698761008625 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761008626 Zn binding site [ion binding]; other site 698761008627 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698761008628 Zn binding site [ion binding]; other site 698761008629 Predicted esterase [General function prediction only]; Region: COG0400 698761008630 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698761008631 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 698761008632 putative active site pocket [active] 698761008633 metal binding site [ion binding]; metal-binding site 698761008634 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698761008635 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698761008636 Cupin domain; Region: Cupin_2; cl17218 698761008637 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698761008638 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698761008639 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698761008640 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698761008641 Walker A/P-loop; other site 698761008642 ATP binding site [chemical binding]; other site 698761008643 Q-loop/lid; other site 698761008644 ABC transporter signature motif; other site 698761008645 Walker B; other site 698761008646 D-loop; other site 698761008647 H-loop/switch region; other site 698761008648 NIL domain; Region: NIL; pfam09383 698761008649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761008650 dimer interface [polypeptide binding]; other site 698761008651 conserved gate region; other site 698761008652 ABC-ATPase subunit interface; other site 698761008653 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698761008654 SPFH domain / Band 7 family; Region: Band_7; pfam01145 698761008655 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 698761008656 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 698761008657 putative ligand binding site [chemical binding]; other site 698761008658 putative NAD binding site [chemical binding]; other site 698761008659 catalytic site [active] 698761008660 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 698761008661 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761008662 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761008663 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761008664 PilZ domain; Region: PilZ; pfam07238 698761008665 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761008666 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761008667 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761008668 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761008669 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761008670 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761008671 Transposase; Region: HTH_Tnp_1; pfam01527 698761008672 putative transposase OrfB; Reviewed; Region: PHA02517 698761008673 HTH-like domain; Region: HTH_21; pfam13276 698761008674 Integrase core domain; Region: rve; pfam00665 698761008675 Integrase core domain; Region: rve_3; pfam13683 698761008676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761008677 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761008678 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761008679 putative transposase OrfB; Reviewed; Region: PHA02517 698761008680 HTH-like domain; Region: HTH_21; pfam13276 698761008681 Integrase core domain; Region: rve; pfam00665 698761008682 Integrase core domain; Region: rve_2; pfam13333 698761008683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761008684 Transposase; Region: HTH_Tnp_1; pfam01527 698761008685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 698761008686 Paired Box domain; Region: PAX; cd00131 698761008687 DNA binding site [nucleotide binding] 698761008688 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698761008689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698761008690 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761008691 Winged helix-turn helix; Region: HTH_29; pfam13551 698761008692 Homeodomain-like domain; Region: HTH_32; pfam13565 698761008693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698761008694 Integrase core domain; Region: rve; pfam00665 698761008695 Integrase core domain; Region: rve_3; pfam13683 698761008696 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698761008697 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698761008698 Ligand Binding Site [chemical binding]; other site 698761008699 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 698761008700 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 698761008701 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698761008702 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698761008703 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698761008704 putative acyl-acceptor binding pocket; other site 698761008705 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698761008706 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698761008707 ligand binding site [chemical binding]; other site 698761008708 NAD binding site [chemical binding]; other site 698761008709 dimerization interface [polypeptide binding]; other site 698761008710 catalytic site [active] 698761008711 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698761008712 putative L-serine binding site [chemical binding]; other site 698761008713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 698761008714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761008715 catalytic residue [active] 698761008716 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 698761008717 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698761008718 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698761008719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 698761008720 Bacterial SH3 domain; Region: SH3_4; pfam06347 698761008721 Bacterial SH3 domain; Region: SH3_4; pfam06347 698761008722 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 698761008723 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698761008724 active site 698761008725 substrate binding site [chemical binding]; other site 698761008726 metal binding site [ion binding]; metal-binding site 698761008727 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 698761008728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761008729 Walker A motif; other site 698761008730 ATP binding site [chemical binding]; other site 698761008731 Walker B motif; other site 698761008732 arginine finger; other site 698761008733 Peptidase family M41; Region: Peptidase_M41; pfam01434 698761008734 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698761008735 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698761008736 Ligand Binding Site [chemical binding]; other site 698761008737 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 698761008738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761008739 TPR motif; other site 698761008740 binding surface 698761008741 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 698761008742 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698761008743 ligand binding site [chemical binding]; other site 698761008744 translocation protein TolB; Provisional; Region: tolB; PRK05137 698761008745 TolB amino-terminal domain; Region: TolB_N; pfam04052 698761008746 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698761008747 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698761008748 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698761008749 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 698761008750 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 698761008751 TolR protein; Region: tolR; TIGR02801 698761008752 TolQ protein; Region: tolQ; TIGR02796 698761008753 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698761008754 active site 698761008755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761008756 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761008757 NAD(P) binding site [chemical binding]; other site 698761008758 active site 698761008759 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 698761008760 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 698761008761 substrate binding site; other site 698761008762 Manganese binding site; other site 698761008763 dimer interface; other site 698761008764 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761008765 extended (e) SDRs; Region: SDR_e; cd08946 698761008766 NAD(P) binding site [chemical binding]; other site 698761008767 active site 698761008768 substrate binding site [chemical binding]; other site 698761008769 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 698761008770 nudix motif; other site 698761008771 phosphodiesterase YaeI; Provisional; Region: PRK11340 698761008772 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698761008773 putative active site [active] 698761008774 putative metal binding site [ion binding]; other site 698761008775 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698761008776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761008777 Walker A motif; other site 698761008778 ATP binding site [chemical binding]; other site 698761008779 Walker B motif; other site 698761008780 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698761008781 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698761008782 RuvA N terminal domain; Region: RuvA_N; pfam01330 698761008783 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 698761008784 putative active site [active] 698761008785 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 698761008786 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 698761008787 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 698761008788 active site 698761008789 putative DNA-binding cleft [nucleotide binding]; other site 698761008790 dimer interface [polypeptide binding]; other site 698761008791 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698761008792 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 698761008793 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 698761008794 Predicted membrane protein [Function unknown]; Region: COG2259 698761008795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761008796 TPR motif; other site 698761008797 TPR repeat; Region: TPR_11; pfam13414 698761008798 binding surface 698761008799 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698761008800 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698761008801 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761008802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761008803 DNA binding residues [nucleotide binding] 698761008804 Putative zinc-finger; Region: zf-HC2; pfam13490 698761008805 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698761008806 hypothetical protein; Validated; Region: PRK00110 698761008807 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698761008808 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 698761008809 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 698761008810 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761008811 putative active site [active] 698761008812 metal binding site [ion binding]; metal-binding site 698761008813 homodimer binding site [polypeptide binding]; other site 698761008814 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698761008815 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698761008816 putative phosphatase; Provisional; Region: PRK11587 698761008817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761008818 motif II; other site 698761008819 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 698761008820 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 698761008821 Predicted integral membrane protein [Function unknown]; Region: COG0392 698761008822 Uncharacterized conserved protein [Function unknown]; Region: COG2898 698761008823 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698761008824 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698761008825 hydrophobic ligand binding site; other site 698761008826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761008827 dimerization interface [polypeptide binding]; other site 698761008828 putative DNA binding site [nucleotide binding]; other site 698761008829 putative Zn2+ binding site [ion binding]; other site 698761008830 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761008831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761008832 salt bridge; other site 698761008833 non-specific DNA binding site [nucleotide binding]; other site 698761008834 sequence-specific DNA binding site [nucleotide binding]; other site 698761008835 short chain dehydrogenase; Provisional; Region: PRK06197 698761008836 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 698761008837 putative NAD(P) binding site [chemical binding]; other site 698761008838 active site 698761008839 short chain dehydrogenase; Provisional; Region: PRK07041 698761008840 classical (c) SDRs; Region: SDR_c; cd05233 698761008841 NAD(P) binding site [chemical binding]; other site 698761008842 active site 698761008843 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761008844 MarR family; Region: MarR_2; pfam12802 698761008845 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 698761008846 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 698761008847 Cl- selectivity filter; other site 698761008848 Cl- binding residues [ion binding]; other site 698761008849 pore gating glutamate residue; other site 698761008850 dimer interface [polypeptide binding]; other site 698761008851 FOG: CBS domain [General function prediction only]; Region: COG0517 698761008852 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 698761008853 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 698761008854 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 698761008855 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698761008856 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698761008857 TPP-binding site [chemical binding]; other site 698761008858 dimer interface [polypeptide binding]; other site 698761008859 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698761008860 PYR/PP interface [polypeptide binding]; other site 698761008861 dimer interface [polypeptide binding]; other site 698761008862 TPP binding site [chemical binding]; other site 698761008863 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698761008864 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 698761008865 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698761008866 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698761008867 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 698761008868 Transporter associated domain; Region: CorC_HlyC; smart01091 698761008869 Phosphoglycerate kinase; Region: PGK; pfam00162 698761008870 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698761008871 substrate binding site [chemical binding]; other site 698761008872 hinge regions; other site 698761008873 ADP binding site [chemical binding]; other site 698761008874 catalytic site [active] 698761008875 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698761008876 Beta-lactamase; Region: Beta-lactamase; pfam00144 698761008877 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698761008878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761008879 putative substrate translocation pore; other site 698761008880 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 698761008881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 698761008882 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 698761008883 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698761008884 G1 box; other site 698761008885 GTP/Mg2+ binding site [chemical binding]; other site 698761008886 G2 box; other site 698761008887 Switch I region; other site 698761008888 G3 box; other site 698761008889 Switch II region; other site 698761008890 G4 box; other site 698761008891 G5 box; other site 698761008892 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 698761008893 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 698761008894 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 698761008895 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 698761008896 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 698761008897 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761008898 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 698761008899 Walker A/P-loop; other site 698761008900 ATP binding site [chemical binding]; other site 698761008901 Q-loop/lid; other site 698761008902 ABC transporter signature motif; other site 698761008903 Walker B; other site 698761008904 D-loop; other site 698761008905 H-loop/switch region; other site 698761008906 Uncharacterized conserved protein [Function unknown]; Region: COG3422 698761008907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 698761008908 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 698761008909 hypothetical protein; Validated; Region: PRK09039 698761008910 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 698761008911 ligand binding site [chemical binding]; other site 698761008912 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698761008913 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698761008914 active site 698761008915 dimerization interface [polypeptide binding]; other site 698761008916 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698761008917 Sel1-like repeats; Region: SEL1; smart00671 698761008918 Sel1-like repeats; Region: SEL1; smart00671 698761008919 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698761008920 thiamine phosphate binding site [chemical binding]; other site 698761008921 active site 698761008922 pyrophosphate binding site [ion binding]; other site 698761008923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761008924 dimerization interface [polypeptide binding]; other site 698761008925 putative DNA binding site [nucleotide binding]; other site 698761008926 putative Zn2+ binding site [ion binding]; other site 698761008927 Uncharacterized small protein [Function unknown]; Region: COG5570 698761008928 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 698761008929 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698761008930 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698761008931 ATP-grasp domain; Region: ATP-grasp; pfam02222 698761008932 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 698761008933 TPR repeat; Region: TPR_11; pfam13414 698761008934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761008935 binding surface 698761008936 TPR motif; other site 698761008937 TPR repeat; Region: TPR_11; pfam13414 698761008938 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761008939 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 698761008940 catalytic site [active] 698761008941 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 698761008942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761008943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761008944 dimerization interface [polypeptide binding]; other site 698761008945 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 698761008946 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698761008947 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 698761008948 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698761008949 tetramer interface [polypeptide binding]; other site 698761008950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761008951 catalytic residue [active] 698761008952 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761008953 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761008954 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761008955 pyruvate kinase; Provisional; Region: PRK06247 698761008956 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698761008957 domain interfaces; other site 698761008958 active site 698761008959 Predicted integral membrane protein [Function unknown]; Region: COG5480 698761008960 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 698761008961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 698761008962 hypothetical protein; Provisional; Region: PRK13694 698761008963 Nitronate monooxygenase; Region: NMO; pfam03060 698761008964 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698761008965 FMN binding site [chemical binding]; other site 698761008966 substrate binding site [chemical binding]; other site 698761008967 putative catalytic residue [active] 698761008968 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761008969 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761008970 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698761008971 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698761008972 homodimer interface [polypeptide binding]; other site 698761008973 substrate-cofactor binding pocket; other site 698761008974 catalytic residue [active] 698761008975 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 698761008976 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698761008977 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 698761008978 putative active site [active] 698761008979 putative metal binding site [ion binding]; other site 698761008980 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 698761008981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 698761008982 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 698761008983 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 698761008984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761008985 active site 698761008986 phosphorylation site [posttranslational modification] 698761008987 intermolecular recognition site; other site 698761008988 dimerization interface [polypeptide binding]; other site 698761008989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761008990 Walker A motif; other site 698761008991 ATP binding site [chemical binding]; other site 698761008992 Walker B motif; other site 698761008993 arginine finger; other site 698761008994 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698761008995 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 698761008996 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 698761008997 active site 698761008998 Zn binding site [ion binding]; other site 698761008999 aminodeoxychorismate synthase; Provisional; Region: PRK07508 698761009000 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698761009001 hypothetical protein; Provisional; Region: PRK07546 698761009002 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698761009003 substrate-cofactor binding pocket; other site 698761009004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761009005 homodimer interface [polypeptide binding]; other site 698761009006 catalytic residue [active] 698761009007 YCII-related domain; Region: YCII; cl00999 698761009008 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 698761009009 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 698761009010 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 698761009011 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 698761009012 active site 698761009013 metal binding site [ion binding]; metal-binding site 698761009014 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698761009015 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 698761009016 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698761009017 ferrochelatase; Reviewed; Region: hemH; PRK00035 698761009018 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698761009019 C-terminal domain interface [polypeptide binding]; other site 698761009020 active site 698761009021 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698761009022 active site 698761009023 N-terminal domain interface [polypeptide binding]; other site 698761009024 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698761009025 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698761009026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761009027 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 698761009028 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698761009029 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 698761009030 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 698761009031 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 698761009032 putative active site [active] 698761009033 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 698761009034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 698761009035 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 698761009036 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698761009037 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698761009038 active site 698761009039 tetramer interface; other site 698761009040 Transglycosylase SLT domain; Region: SLT_2; pfam13406 698761009041 murein hydrolase B; Provisional; Region: PRK10760; cl17906 698761009042 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761009043 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 698761009044 active site 698761009045 catalytic triad [active] 698761009046 oxyanion hole [active] 698761009047 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698761009048 active site 698761009049 dimer interface [polypeptide binding]; other site 698761009050 motif 2; other site 698761009051 motif 3; other site 698761009052 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761009053 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 698761009054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761009055 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 698761009056 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 698761009057 active site 698761009058 dimer interface [polypeptide binding]; other site 698761009059 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 698761009060 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 698761009061 active site 698761009062 FMN binding site [chemical binding]; other site 698761009063 substrate binding site [chemical binding]; other site 698761009064 3Fe-4S cluster binding site [ion binding]; other site 698761009065 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 698761009066 domain interface; other site 698761009067 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 698761009068 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 698761009069 tetramer interface [polypeptide binding]; other site 698761009070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761009071 catalytic residue [active] 698761009072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761009073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761009074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761009075 dimerization interface [polypeptide binding]; other site 698761009076 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698761009077 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 698761009078 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698761009079 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 698761009080 putative dimer interface [polypeptide binding]; other site 698761009081 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 698761009082 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761009083 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761009084 putative DNA binding site [nucleotide binding]; other site 698761009085 putative Zn2+ binding site [ion binding]; other site 698761009086 AsnC family; Region: AsnC_trans_reg; pfam01037 698761009087 Ion transport protein; Region: Ion_trans; pfam00520 698761009088 Ion channel; Region: Ion_trans_2; pfam07885 698761009089 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698761009090 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761009091 ligand binding site [chemical binding]; other site 698761009092 flexible hinge region; other site 698761009093 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698761009094 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761009095 TAP-like protein; Region: Abhydrolase_4; pfam08386 698761009096 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698761009097 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698761009098 active site 698761009099 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 698761009100 Response regulator receiver domain; Region: Response_reg; pfam00072 698761009101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761009102 active site 698761009103 phosphorylation site [posttranslational modification] 698761009104 intermolecular recognition site; other site 698761009105 dimerization interface [polypeptide binding]; other site 698761009106 hypothetical protein; Provisional; Region: PRK14013 698761009107 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 698761009108 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 698761009109 Substrate binding site; other site 698761009110 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 698761009111 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 698761009112 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 698761009113 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 698761009114 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 698761009115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 698761009116 Uncharacterized conserved protein [Function unknown]; Region: COG2308 698761009117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 698761009118 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 698761009119 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 698761009120 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 698761009121 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 698761009122 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698761009123 metal ion-dependent adhesion site (MIDAS); other site 698761009124 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698761009125 homodimer interface [polypeptide binding]; other site 698761009126 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698761009127 active site pocket [active] 698761009128 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761009129 MULE transposase domain; Region: MULE; pfam10551 698761009130 glycogen branching enzyme; Provisional; Region: PRK05402 698761009131 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698761009132 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698761009133 active site 698761009134 catalytic site [active] 698761009135 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 698761009136 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 698761009137 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698761009138 ligand binding site; other site 698761009139 oligomer interface; other site 698761009140 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698761009141 dimer interface [polypeptide binding]; other site 698761009142 N-terminal domain interface [polypeptide binding]; other site 698761009143 sulfate 1 binding site; other site 698761009144 glycogen synthase; Provisional; Region: glgA; PRK00654 698761009145 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 698761009146 ADP-binding pocket [chemical binding]; other site 698761009147 homodimer interface [polypeptide binding]; other site 698761009148 phosphoglucomutase; Region: PLN02307 698761009149 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 698761009150 substrate binding site [chemical binding]; other site 698761009151 dimer interface [polypeptide binding]; other site 698761009152 active site 698761009153 metal binding site [ion binding]; metal-binding site 698761009154 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698761009155 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698761009156 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698761009157 active site 698761009158 catalytic site [active] 698761009159 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 698761009160 putative active site [active] 698761009161 putative catalytic site [active] 698761009162 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 698761009163 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 698761009164 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698761009165 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761009166 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 698761009167 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 698761009168 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761009169 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 698761009170 TPR repeat; Region: TPR_11; pfam13414 698761009171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761009172 TPR motif; other site 698761009173 binding surface 698761009174 TPR repeat; Region: TPR_11; pfam13414 698761009175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761009176 binding surface 698761009177 TPR motif; other site 698761009178 TPR repeat; Region: TPR_11; pfam13414 698761009179 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761009180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698761009181 HWE histidine kinase; Region: HWE_HK; smart00911 698761009182 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 698761009183 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 698761009184 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 698761009185 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 698761009186 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 698761009187 ligand binding site [chemical binding]; other site 698761009188 homodimer interface [polypeptide binding]; other site 698761009189 NAD(P) binding site [chemical binding]; other site 698761009190 trimer interface B [polypeptide binding]; other site 698761009191 trimer interface A [polypeptide binding]; other site 698761009192 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 698761009193 PAS domain; Region: PAS; smart00091 698761009194 PAS fold; Region: PAS_7; pfam12860 698761009195 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761009196 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761009197 metal binding site [ion binding]; metal-binding site 698761009198 active site 698761009199 I-site; other site 698761009200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761009201 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 698761009202 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 698761009203 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 698761009204 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 698761009205 catalytic triad [active] 698761009206 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698761009207 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 698761009208 putative ligand binding site [chemical binding]; other site 698761009209 NAD binding site [chemical binding]; other site 698761009210 catalytic site [active] 698761009211 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761009212 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761009213 DNA binding site [nucleotide binding] 698761009214 domain linker motif; other site 698761009215 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 698761009216 putative dimerization interface [polypeptide binding]; other site 698761009217 putative ligand binding site [chemical binding]; other site 698761009218 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761009219 MarR family; Region: MarR_2; pfam12802 698761009220 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 698761009221 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698761009222 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 698761009223 P-loop, Walker A motif; other site 698761009224 Base recognition motif; other site 698761009225 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698761009226 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 698761009227 FOG: WD40 repeat [General function prediction only]; Region: COG2319 698761009228 structural tetrad; other site 698761009229 serine acetyltransferase; Provisional; Region: cysE; PRK11132 698761009230 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 698761009231 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698761009232 trimer interface [polypeptide binding]; other site 698761009233 active site 698761009234 substrate binding site [chemical binding]; other site 698761009235 CoA binding site [chemical binding]; other site 698761009236 Phosphoesterase family; Region: Phosphoesterase; pfam04185 698761009237 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 698761009238 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 698761009239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761009240 Coenzyme A binding pocket [chemical binding]; other site 698761009241 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 698761009242 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 698761009243 active site 698761009244 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698761009245 dimer interface [polypeptide binding]; other site 698761009246 catalytic residues [active] 698761009247 substrate binding site [chemical binding]; other site 698761009248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761009249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761009250 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761009251 putative effector binding pocket; other site 698761009252 dimerization interface [polypeptide binding]; other site 698761009253 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 698761009254 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 698761009255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 698761009256 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 698761009257 putative metal binding site [ion binding]; other site 698761009258 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 698761009259 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 698761009260 active site 698761009261 intersubunit interface [polypeptide binding]; other site 698761009262 catalytic residue [active] 698761009263 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 698761009264 putative active site [active] 698761009265 putative metal binding residues [ion binding]; other site 698761009266 signature motif; other site 698761009267 putative dimer interface [polypeptide binding]; other site 698761009268 putative phosphate binding site [ion binding]; other site 698761009269 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 698761009270 hypothetical protein; Provisional; Region: PRK06184 698761009271 hypothetical protein; Provisional; Region: PRK07236 698761009272 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761009273 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761009274 MarR family; Region: MarR; pfam01047 698761009275 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 698761009276 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698761009277 active site residue [active] 698761009278 CHASE4 domain; Region: CHASE4; pfam05228 698761009279 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761009280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761009281 metal binding site [ion binding]; metal-binding site 698761009282 active site 698761009283 I-site; other site 698761009284 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761009285 Predicted flavoprotein [General function prediction only]; Region: COG0431 698761009286 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761009287 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 698761009288 beta-galactosidase; Region: BGL; TIGR03356 698761009289 Predicted membrane protein [Function unknown]; Region: COG2259 698761009290 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761009291 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761009292 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761009293 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761009294 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698761009295 AP (apurinic/apyrimidinic) site pocket; other site 698761009296 DNA interaction; other site 698761009297 Metal-binding active site; metal-binding site 698761009298 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 698761009299 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761009300 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 698761009301 putative ligand binding site [chemical binding]; other site 698761009302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761009303 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761009304 TM-ABC transporter signature motif; other site 698761009305 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761009306 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761009307 Walker A/P-loop; other site 698761009308 ATP binding site [chemical binding]; other site 698761009309 Q-loop/lid; other site 698761009310 ABC transporter signature motif; other site 698761009311 Walker B; other site 698761009312 D-loop; other site 698761009313 H-loop/switch region; other site 698761009314 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761009315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761009316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761009317 DNA binding site [nucleotide binding] 698761009318 domain linker motif; other site 698761009319 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 698761009320 dimerization interface [polypeptide binding]; other site 698761009321 ligand binding site [chemical binding]; other site 698761009322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761009323 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698761009324 active site 698761009325 xylose isomerase; Provisional; Region: PRK05474 698761009326 xylose isomerase; Region: xylose_isom_A; TIGR02630 698761009327 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 698761009328 N- and C-terminal domain interface [polypeptide binding]; other site 698761009329 L-fuculokinase; Region: fuculo_kin_coli; TIGR02628 698761009330 active site 698761009331 MgATP binding site [chemical binding]; other site 698761009332 catalytic site [active] 698761009333 metal binding site [ion binding]; metal-binding site 698761009334 xylulose binding site [chemical binding]; other site 698761009335 homodimer interface [polypeptide binding]; other site 698761009336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761009337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761009338 DNA binding site [nucleotide binding] 698761009339 domain linker motif; other site 698761009340 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 698761009341 putative ligand binding site [chemical binding]; other site 698761009342 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698761009343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761009344 putative substrate translocation pore; other site 698761009345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761009346 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 698761009347 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761009348 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761009349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761009350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761009351 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 698761009352 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761009353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761009354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 698761009355 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 698761009356 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698761009357 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698761009358 HIGH motif; other site 698761009359 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698761009360 active site 698761009361 KMSKS motif; other site 698761009362 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698761009363 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698761009364 dimer interface [polypeptide binding]; other site 698761009365 putative anticodon binding site; other site 698761009366 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 698761009367 motif 1; other site 698761009368 active site 698761009369 motif 2; other site 698761009370 motif 3; other site 698761009371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761009372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761009373 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 698761009374 putative substrate binding pocket [chemical binding]; other site 698761009375 dimerization interface [polypeptide binding]; other site 698761009376 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698761009377 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698761009378 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761009379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761009380 Walker A/P-loop; other site 698761009381 ATP binding site [chemical binding]; other site 698761009382 Q-loop/lid; other site 698761009383 ABC transporter signature motif; other site 698761009384 Walker B; other site 698761009385 D-loop; other site 698761009386 H-loop/switch region; other site 698761009387 TOBE domain; Region: TOBE_2; pfam08402 698761009388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761009389 dimer interface [polypeptide binding]; other site 698761009390 conserved gate region; other site 698761009391 putative PBP binding loops; other site 698761009392 ABC-ATPase subunit interface; other site 698761009393 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761009394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761009395 dimer interface [polypeptide binding]; other site 698761009396 conserved gate region; other site 698761009397 putative PBP binding loops; other site 698761009398 ABC-ATPase subunit interface; other site 698761009399 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 698761009400 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 698761009401 tetrameric interface [polypeptide binding]; other site 698761009402 NAD binding site [chemical binding]; other site 698761009403 catalytic residues [active] 698761009404 substrate binding site [chemical binding]; other site 698761009405 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761009406 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761009407 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761009408 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 698761009409 short chain dehydrogenase; Provisional; Region: PRK06138 698761009410 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 698761009411 NAD binding site [chemical binding]; other site 698761009412 homotetramer interface [polypeptide binding]; other site 698761009413 homodimer interface [polypeptide binding]; other site 698761009414 active site 698761009415 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698761009416 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761009417 putative DNA binding site [nucleotide binding]; other site 698761009418 putative Zn2+ binding site [ion binding]; other site 698761009419 Bacterial transcriptional regulator; Region: IclR; pfam01614 698761009420 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 698761009421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 698761009422 active site 698761009423 transaldolase-like protein; Provisional; Region: PTZ00411 698761009424 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 698761009425 active site 698761009426 dimer interface [polypeptide binding]; other site 698761009427 catalytic residue [active] 698761009428 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698761009429 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 698761009430 DNA binding residues [nucleotide binding] 698761009431 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698761009432 Helix-turn-helix domain; Region: HTH_18; pfam12833 698761009433 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698761009434 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698761009435 DNA binding site [nucleotide binding] 698761009436 active site 698761009437 Integral membrane protein [Function unknown]; Region: COG5488 698761009438 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698761009439 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698761009440 minor groove reading motif; other site 698761009441 helix-hairpin-helix signature motif; other site 698761009442 substrate binding pocket [chemical binding]; other site 698761009443 active site 698761009444 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 698761009445 CysZ-like protein; Reviewed; Region: PRK12768 698761009446 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698761009447 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698761009448 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 698761009449 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 698761009450 N- and C-terminal domain interface [polypeptide binding]; other site 698761009451 active site 698761009452 MgATP binding site [chemical binding]; other site 698761009453 catalytic site [active] 698761009454 metal binding site [ion binding]; metal-binding site 698761009455 carbohydrate binding site [chemical binding]; other site 698761009456 putative homodimer interface [polypeptide binding]; other site 698761009457 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 698761009458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761009459 active site 698761009460 motif II; other site 698761009461 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 698761009462 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 698761009463 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 698761009464 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761009465 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761009466 Walker A/P-loop; other site 698761009467 ATP binding site [chemical binding]; other site 698761009468 Q-loop/lid; other site 698761009469 ABC transporter signature motif; other site 698761009470 Walker B; other site 698761009471 D-loop; other site 698761009472 H-loop/switch region; other site 698761009473 TOBE domain; Region: TOBE_2; pfam08402 698761009474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761009475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761009476 dimer interface [polypeptide binding]; other site 698761009477 conserved gate region; other site 698761009478 putative PBP binding loops; other site 698761009479 ABC-ATPase subunit interface; other site 698761009480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761009481 dimer interface [polypeptide binding]; other site 698761009482 conserved gate region; other site 698761009483 putative PBP binding loops; other site 698761009484 ABC-ATPase subunit interface; other site 698761009485 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761009486 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761009487 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698761009488 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698761009489 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 698761009490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761009491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761009492 active site 698761009493 phosphorylation site [posttranslational modification] 698761009494 intermolecular recognition site; other site 698761009495 dimerization interface [polypeptide binding]; other site 698761009496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761009497 DNA binding site [nucleotide binding] 698761009498 sensor protein QseC; Provisional; Region: PRK10337 698761009499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761009500 dimer interface [polypeptide binding]; other site 698761009501 phosphorylation site [posttranslational modification] 698761009502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761009503 ATP binding site [chemical binding]; other site 698761009504 Mg2+ binding site [ion binding]; other site 698761009505 G-X-G motif; other site 698761009506 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761009507 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761009508 nucleotide binding site [chemical binding]; other site 698761009509 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 698761009510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761009511 putative transporter; Provisional; Region: PRK10504 698761009512 putative substrate translocation pore; other site 698761009513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761009514 SpoVR family protein; Provisional; Region: PRK11767 698761009515 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 698761009516 hypothetical protein; Provisional; Region: PRK05325 698761009517 PrkA family serine protein kinase; Provisional; Region: PRK15455 698761009518 AAA ATPase domain; Region: AAA_16; pfam13191 698761009519 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 698761009520 zinc-binding protein; Provisional; Region: PRK01343 698761009521 Maf-like protein; Region: Maf; pfam02545 698761009522 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698761009523 active site 698761009524 dimer interface [polypeptide binding]; other site 698761009525 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698761009526 rRNA binding site [nucleotide binding]; other site 698761009527 predicted 30S ribosome binding site; other site 698761009528 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698761009529 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698761009530 active site 698761009531 hypothetical protein; Provisional; Region: PRK02853 698761009532 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 698761009533 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698761009534 NAD binding site [chemical binding]; other site 698761009535 dimerization interface [polypeptide binding]; other site 698761009536 product binding site; other site 698761009537 substrate binding site [chemical binding]; other site 698761009538 zinc binding site [ion binding]; other site 698761009539 catalytic residues [active] 698761009540 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 698761009541 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698761009542 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698761009543 hinge; other site 698761009544 active site 698761009545 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 698761009546 Family description; Region: UvrD_C_2; pfam13538 698761009547 Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396 698761009548 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698761009549 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698761009550 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698761009551 CAP-Gly domain; Region: CAP_GLY; cl08315 698761009552 Protein of unknown function, DUF1537; Region: DUF1537; pfam07005 698761009553 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 698761009554 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 698761009555 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 698761009556 dimer interface [polypeptide binding]; other site 698761009557 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761009558 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 698761009559 active site 698761009560 metal binding site [ion binding]; metal-binding site 698761009561 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698761009562 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761009563 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761009564 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761009565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761009566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761009567 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 698761009568 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761009569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761009570 DNA-binding site [nucleotide binding]; DNA binding site 698761009571 FCD domain; Region: FCD; pfam07729 698761009572 galactonate dehydratase; Provisional; Region: PRK14017 698761009573 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 698761009574 putative active site pocket [active] 698761009575 putative metal binding site [ion binding]; other site 698761009576 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 698761009577 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 698761009578 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 698761009579 RNA polymerase sigma factor; Provisional; Region: PRK12511 698761009580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761009581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761009582 DNA binding residues [nucleotide binding] 698761009583 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 698761009584 methionine sulfoxide reductase A; Provisional; Region: PRK13014 698761009585 hypothetical protein; Provisional; Region: PRK00736 698761009586 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698761009587 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698761009588 active site 698761009589 metal binding site [ion binding]; metal-binding site 698761009590 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761009591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761009592 Walker A/P-loop; other site 698761009593 ATP binding site [chemical binding]; other site 698761009594 Q-loop/lid; other site 698761009595 ABC transporter signature motif; other site 698761009596 Walker B; other site 698761009597 D-loop; other site 698761009598 H-loop/switch region; other site 698761009599 TOBE domain; Region: TOBE_2; pfam08402 698761009600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761009601 dimer interface [polypeptide binding]; other site 698761009602 conserved gate region; other site 698761009603 putative PBP binding loops; other site 698761009604 ABC-ATPase subunit interface; other site 698761009605 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761009606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761009607 dimer interface [polypeptide binding]; other site 698761009608 conserved gate region; other site 698761009609 putative PBP binding loops; other site 698761009610 ABC-ATPase subunit interface; other site 698761009611 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761009612 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761009613 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761009614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761009615 DNA binding site [nucleotide binding] 698761009616 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698761009617 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 698761009618 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 698761009619 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 698761009620 dimer interface [polypeptide binding]; other site 698761009621 NADP binding site [chemical binding]; other site 698761009622 catalytic residues [active] 698761009623 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698761009624 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698761009625 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698761009626 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761009627 ligand binding site [chemical binding]; other site 698761009628 flexible hinge region; other site 698761009629 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 698761009630 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761009631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761009632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761009633 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 698761009634 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 698761009635 Isochorismatase family; Region: Isochorismatase; pfam00857 698761009636 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698761009637 catalytic triad [active] 698761009638 conserved cis-peptide bond; other site 698761009639 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761009640 MarR family; Region: MarR_2; cl17246 698761009641 haloalkane dehalogenase; Provisional; Region: PRK03592 698761009642 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698761009643 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761009644 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761009645 substrate binding pocket [chemical binding]; other site 698761009646 membrane-bound complex binding site; other site 698761009647 hinge residues; other site 698761009648 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761009649 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761009650 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698761009651 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761009652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761009653 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 698761009654 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 698761009655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761009656 S-adenosylmethionine binding site [chemical binding]; other site 698761009657 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698761009658 Peptidase family M23; Region: Peptidase_M23; pfam01551 698761009659 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698761009660 Clp amino terminal domain; Region: Clp_N; pfam02861 698761009661 Clp amino terminal domain; Region: Clp_N; pfam02861 698761009662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761009663 Walker A motif; other site 698761009664 ATP binding site [chemical binding]; other site 698761009665 Walker B motif; other site 698761009666 arginine finger; other site 698761009667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761009668 Walker A motif; other site 698761009669 ATP binding site [chemical binding]; other site 698761009670 Walker B motif; other site 698761009671 arginine finger; other site 698761009672 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698761009673 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 698761009674 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698761009675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761009676 S-adenosylmethionine binding site [chemical binding]; other site 698761009677 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698761009678 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698761009679 RF-1 domain; Region: RF-1; pfam00472 698761009680 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 698761009681 GAF domain; Region: GAF; pfam01590 698761009682 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698761009683 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698761009684 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698761009685 aspartate kinase; Reviewed; Region: PRK06635 698761009686 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698761009687 putative nucleotide binding site [chemical binding]; other site 698761009688 putative catalytic residues [active] 698761009689 putative Mg ion binding site [ion binding]; other site 698761009690 putative aspartate binding site [chemical binding]; other site 698761009691 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698761009692 putative allosteric regulatory site; other site 698761009693 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698761009694 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 698761009695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761009696 S-adenosylmethionine binding site [chemical binding]; other site 698761009697 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 698761009698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 698761009699 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698761009700 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 698761009701 putative active site [active] 698761009702 catalytic triad [active] 698761009703 dimer interface [polypeptide binding]; other site 698761009704 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 698761009705 GSH binding site [chemical binding]; other site 698761009706 catalytic residues [active] 698761009707 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698761009708 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 698761009709 Flp/Fap pilin component; Region: Flp_Fap; cl01585 698761009710 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698761009711 active site 698761009712 8-oxo-dGMP binding site [chemical binding]; other site 698761009713 nudix motif; other site 698761009714 metal binding site [ion binding]; metal-binding site 698761009715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761009716 Coenzyme A binding pocket [chemical binding]; other site 698761009717 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698761009718 heterotetramer interface [polypeptide binding]; other site 698761009719 active site pocket [active] 698761009720 cleavage site 698761009721 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 698761009722 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698761009723 DEAD/DEAH box helicase; Region: DEAD; pfam00270 698761009724 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 698761009725 SEC-C motif; Region: SEC-C; pfam02810 698761009726 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761009727 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 698761009728 putative C-terminal domain interface [polypeptide binding]; other site 698761009729 putative GSH binding site (G-site) [chemical binding]; other site 698761009730 putative dimer interface [polypeptide binding]; other site 698761009731 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 698761009732 N-terminal domain interface [polypeptide binding]; other site 698761009733 dimer interface [polypeptide binding]; other site 698761009734 substrate binding pocket (H-site) [chemical binding]; other site 698761009735 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698761009736 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 698761009737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 698761009738 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 698761009739 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 698761009740 active site 698761009741 acyl-activating enzyme (AAE) consensus motif; other site 698761009742 putative CoA binding site [chemical binding]; other site 698761009743 AMP binding site [chemical binding]; other site 698761009744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761009745 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761009746 active site 698761009747 catalytic tetrad [active] 698761009748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761009749 S-adenosylmethionine binding site [chemical binding]; other site 698761009750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761009751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761009752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761009753 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761009754 putative substrate translocation pore; other site 698761009755 Protein of unknown function DUF262; Region: DUF262; pfam03235 698761009756 Uncharacterized conserved protein [Function unknown]; Region: COG1479 698761009757 Predicted membrane protein [Function unknown]; Region: COG1238 698761009758 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 698761009759 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 698761009760 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698761009761 active site 698761009762 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 698761009763 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698761009764 minor groove reading motif; other site 698761009765 helix-hairpin-helix signature motif; other site 698761009766 substrate binding pocket [chemical binding]; other site 698761009767 active site 698761009768 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 698761009769 active site 698761009770 HIGH motif; other site 698761009771 nucleotide binding site [chemical binding]; other site 698761009772 active site 698761009773 KMSKS motif; other site 698761009774 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 698761009775 short chain dehydrogenase; Provisional; Region: PRK05993 698761009776 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761009777 NADP binding site [chemical binding]; other site 698761009778 active site 698761009779 steroid binding site; other site 698761009780 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 698761009781 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 698761009782 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698761009783 Ligand binding site [chemical binding]; other site 698761009784 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698761009785 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698761009786 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698761009787 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698761009788 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 698761009789 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698761009790 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698761009791 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698761009792 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698761009793 catalytic residues [active] 698761009794 argininosuccinate lyase; Provisional; Region: PRK00855 698761009795 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698761009796 active sites [active] 698761009797 tetramer interface [polypeptide binding]; other site 698761009798 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698761009799 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698761009800 active site 698761009801 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698761009802 substrate binding site [chemical binding]; other site 698761009803 catalytic residues [active] 698761009804 dimer interface [polypeptide binding]; other site 698761009805 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 698761009806 CHASE3 domain; Region: CHASE3; cl05000 698761009807 Cupin domain; Region: Cupin_2; cl17218 698761009808 Response regulator receiver domain; Region: Response_reg; pfam00072 698761009809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761009810 active site 698761009811 phosphorylation site [posttranslational modification] 698761009812 intermolecular recognition site; other site 698761009813 dimerization interface [polypeptide binding]; other site 698761009814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761009815 active site 698761009816 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 698761009817 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698761009818 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698761009819 Walker A/P-loop; other site 698761009820 ATP binding site [chemical binding]; other site 698761009821 Q-loop/lid; other site 698761009822 ABC transporter signature motif; other site 698761009823 Walker B; other site 698761009824 D-loop; other site 698761009825 H-loop/switch region; other site 698761009826 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698761009827 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698761009828 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698761009829 putative active site [active] 698761009830 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698761009831 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698761009832 putative acyl-acceptor binding pocket; other site 698761009833 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 698761009834 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 698761009835 putative active site pocket [active] 698761009836 dimerization interface [polypeptide binding]; other site 698761009837 putative catalytic residue [active] 698761009838 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 698761009839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761009840 Coenzyme A binding pocket [chemical binding]; other site 698761009841 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 698761009842 prephenate dehydrogenase; Validated; Region: PRK08507 698761009843 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698761009844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761009845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761009846 homodimer interface [polypeptide binding]; other site 698761009847 catalytic residue [active] 698761009848 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698761009849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761009850 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 698761009851 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 698761009852 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 698761009853 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 698761009854 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 698761009855 aromatic amino acid exporter; Provisional; Region: PRK11689 698761009856 EamA-like transporter family; Region: EamA; pfam00892 698761009857 EamA-like transporter family; Region: EamA; pfam00892 698761009858 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 698761009859 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698761009860 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 698761009861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 698761009862 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 698761009863 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 698761009864 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 698761009865 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 698761009866 metal ion-dependent adhesion site (MIDAS); other site 698761009867 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 698761009868 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 698761009869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 698761009870 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 698761009871 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698761009872 HSP70 interaction site [polypeptide binding]; other site 698761009873 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 698761009874 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 698761009875 Domain of unknown function DUF21; Region: DUF21; pfam01595 698761009876 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698761009877 Transporter associated domain; Region: CorC_HlyC; smart01091 698761009878 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698761009879 active site 698761009880 dimer interface [polypeptide binding]; other site 698761009881 metal binding site [ion binding]; metal-binding site 698761009882 shikimate kinase; Provisional; Region: PRK13946 698761009883 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698761009884 ADP binding site [chemical binding]; other site 698761009885 magnesium binding site [ion binding]; other site 698761009886 putative shikimate binding site; other site 698761009887 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698761009888 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698761009889 active site 698761009890 DNA binding site [nucleotide binding] 698761009891 Int/Topo IB signature motif; other site 698761009892 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 698761009893 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 698761009894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 698761009895 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 698761009896 CPxP motif; other site 698761009897 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698761009898 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698761009899 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698761009900 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698761009901 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698761009902 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698761009903 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 698761009904 metal binding site [ion binding]; metal-binding site 698761009905 putative dimer interface [polypeptide binding]; other site 698761009906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761009907 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698761009908 Walker A/P-loop; other site 698761009909 ATP binding site [chemical binding]; other site 698761009910 BON domain; Region: BON; pfam04972 698761009911 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698761009912 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698761009913 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698761009914 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698761009915 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698761009916 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 698761009917 substrate-cofactor binding pocket; other site 698761009918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761009919 catalytic residue [active] 698761009920 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698761009921 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698761009922 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698761009923 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698761009924 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761009925 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698761009926 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698761009927 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 698761009928 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 698761009929 Surface antigen; Region: Bac_surface_Ag; pfam01103 698761009930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 698761009931 Family of unknown function (DUF490); Region: DUF490; pfam04357 698761009932 Arginase family; Region: Arginase; cd09989 698761009933 active site 698761009934 Mn binding site [ion binding]; other site 698761009935 oligomer interface [polypeptide binding]; other site 698761009936 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 698761009937 putative CheA interaction surface; other site 698761009938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761009939 PAS domain; Region: PAS_9; pfam13426 698761009940 putative active site [active] 698761009941 heme pocket [chemical binding]; other site 698761009942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761009943 PAS domain; Region: PAS_9; pfam13426 698761009944 putative active site [active] 698761009945 heme pocket [chemical binding]; other site 698761009946 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761009947 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761009948 dimer interface [polypeptide binding]; other site 698761009949 putative CheW interface [polypeptide binding]; other site 698761009950 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 698761009951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761009952 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 698761009953 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 698761009954 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 698761009955 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761009956 catalytic loop [active] 698761009957 iron binding site [ion binding]; other site 698761009958 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 698761009959 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 698761009960 [4Fe-4S] binding site [ion binding]; other site 698761009961 molybdopterin cofactor binding site; other site 698761009962 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 698761009963 molybdopterin cofactor binding site; other site 698761009964 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 698761009965 putative dimer interface [polypeptide binding]; other site 698761009966 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 698761009967 SLBB domain; Region: SLBB; pfam10531 698761009968 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 698761009969 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 698761009970 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 698761009971 putative dimer interface [polypeptide binding]; other site 698761009972 [2Fe-2S] cluster binding site [ion binding]; other site 698761009973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761009974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761009975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698761009976 dimerization interface [polypeptide binding]; other site 698761009977 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761009978 dimerization interface [polypeptide binding]; other site 698761009979 putative DNA binding site [nucleotide binding]; other site 698761009980 putative Zn2+ binding site [ion binding]; other site 698761009981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761009982 classical (c) SDRs; Region: SDR_c; cd05233 698761009983 NAD(P) binding site [chemical binding]; other site 698761009984 active site 698761009985 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761009986 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698761009987 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761009988 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 698761009989 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 698761009990 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 698761009991 DNA binding residues [nucleotide binding] 698761009992 dimer interface [polypeptide binding]; other site 698761009993 [2Fe-2S] cluster binding site [ion binding]; other site 698761009994 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761009995 Predicted flavoprotein [General function prediction only]; Region: COG0431 698761009996 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761009997 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698761009998 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 698761009999 active site pocket [active] 698761010000 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761010001 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 698761010002 NAD(P) binding site [chemical binding]; other site 698761010003 catalytic residues [active] 698761010004 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 698761010005 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 698761010006 active site 698761010007 NAD binding site [chemical binding]; other site 698761010008 metal binding site [ion binding]; metal-binding site 698761010009 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761010010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761010011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761010012 dimerization interface [polypeptide binding]; other site 698761010013 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698761010014 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698761010015 gamma subunit interface [polypeptide binding]; other site 698761010016 epsilon subunit interface [polypeptide binding]; other site 698761010017 LBP interface [polypeptide binding]; other site 698761010018 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698761010019 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698761010020 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698761010021 alpha subunit interaction interface [polypeptide binding]; other site 698761010022 Walker A motif; other site 698761010023 ATP binding site [chemical binding]; other site 698761010024 Walker B motif; other site 698761010025 inhibitor binding site; inhibition site 698761010026 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698761010027 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698761010028 core domain interface [polypeptide binding]; other site 698761010029 delta subunit interface [polypeptide binding]; other site 698761010030 epsilon subunit interface [polypeptide binding]; other site 698761010031 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698761010032 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698761010033 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698761010034 beta subunit interaction interface [polypeptide binding]; other site 698761010035 Walker A motif; other site 698761010036 ATP binding site [chemical binding]; other site 698761010037 Walker B motif; other site 698761010038 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698761010039 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 698761010040 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698761010041 primosome assembly protein PriA; Validated; Region: PRK05580 698761010042 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698761010043 ATP binding site [chemical binding]; other site 698761010044 putative Mg++ binding site [ion binding]; other site 698761010045 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698761010046 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 698761010047 protein binding site [polypeptide binding]; other site 698761010048 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 698761010049 Active site serine [active] 698761010050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761010051 NAD(P) binding site [chemical binding]; other site 698761010052 active site 698761010053 Predicted ATPase [General function prediction only]; Region: COG4637 698761010054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761010055 Walker A/P-loop; other site 698761010056 ATP binding site [chemical binding]; other site 698761010057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761010058 Q-loop/lid; other site 698761010059 ABC transporter signature motif; other site 698761010060 Walker B; other site 698761010061 D-loop; other site 698761010062 H-loop/switch region; other site 698761010063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 698761010064 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698761010065 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698761010066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698761010067 active site 698761010068 DNA binding site [nucleotide binding] 698761010069 Int/Topo IB signature motif; other site 698761010070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 698761010071 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698761010072 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698761010073 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 698761010074 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698761010075 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698761010076 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 698761010077 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 698761010078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761010079 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698761010080 LysE type translocator; Region: LysE; cl00565 698761010081 short chain dehydrogenase; Provisional; Region: PRK06123 698761010082 classical (c) SDRs; Region: SDR_c; cd05233 698761010083 NAD(P) binding site [chemical binding]; other site 698761010084 active site 698761010085 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 698761010086 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 698761010087 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698761010088 E3 interaction surface; other site 698761010089 lipoyl attachment site [posttranslational modification]; other site 698761010090 e3 binding domain; Region: E3_binding; pfam02817 698761010091 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698761010092 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 698761010093 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698761010094 TPP-binding site [chemical binding]; other site 698761010095 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698761010096 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 698761010097 CoA binding domain; Region: CoA_binding; smart00881 698761010098 CoA-ligase; Region: Ligase_CoA; pfam00549 698761010099 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 698761010100 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 698761010101 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 698761010102 CoA-ligase; Region: Ligase_CoA; pfam00549 698761010103 malate dehydrogenase; Reviewed; Region: PRK06223 698761010104 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 698761010105 NAD(P) binding site [chemical binding]; other site 698761010106 dimer interface [polypeptide binding]; other site 698761010107 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698761010108 substrate binding site [chemical binding]; other site 698761010109 Predicted ATPase [General function prediction only]; Region: COG1485 698761010110 Protease inhibitor Inh; Region: Inh; pfam02974 698761010111 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 698761010112 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 698761010113 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698761010114 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 698761010115 L-aspartate oxidase; Provisional; Region: PRK06175 698761010116 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698761010117 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 698761010118 putative SdhC subunit interface [polypeptide binding]; other site 698761010119 putative proximal heme binding site [chemical binding]; other site 698761010120 putative Iron-sulfur protein interface [polypeptide binding]; other site 698761010121 putative proximal quinone binding site; other site 698761010122 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 698761010123 Iron-sulfur protein interface; other site 698761010124 proximal quinone binding site [chemical binding]; other site 698761010125 SdhD (CybS) interface [polypeptide binding]; other site 698761010126 proximal heme binding site [chemical binding]; other site 698761010127 Predicted methyltransferase [General function prediction only]; Region: COG3897 698761010128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761010129 S-adenosylmethionine binding site [chemical binding]; other site 698761010130 EVE domain; Region: EVE; cl00728 698761010131 YciI-like protein; Reviewed; Region: PRK12865 698761010132 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698761010133 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698761010134 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698761010135 UGMP family protein; Validated; Region: PRK09604 698761010136 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 698761010137 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698761010138 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 698761010139 domain interfaces; other site 698761010140 active site 698761010141 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698761010142 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698761010143 active site 698761010144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 698761010145 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 698761010146 HemY protein N-terminus; Region: HemY_N; pfam07219 698761010147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 698761010148 binding surface 698761010149 TPR motif; other site 698761010150 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 698761010151 putative metal binding site [ion binding]; other site 698761010152 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698761010153 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698761010154 catalytic triad [active] 698761010155 Protein of unknown function (DUF867); Region: DUF867; pfam05908 698761010156 H+ Antiporter protein; Region: 2A0121; TIGR00900 698761010157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761010158 putative substrate translocation pore; other site 698761010159 YGGT family; Region: YGGT; pfam02325 698761010160 hypothetical protein; Validated; Region: PRK01310 698761010161 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698761010162 dimer interface [polypeptide binding]; other site 698761010163 substrate binding site [chemical binding]; other site 698761010164 metal binding sites [ion binding]; metal-binding site 698761010165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761010166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761010167 Coenzyme A binding pocket [chemical binding]; other site 698761010168 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698761010169 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 698761010170 G1 box; other site 698761010171 putative GEF interaction site [polypeptide binding]; other site 698761010172 GTP/Mg2+ binding site [chemical binding]; other site 698761010173 Switch I region; other site 698761010174 G2 box; other site 698761010175 G3 box; other site 698761010176 Switch II region; other site 698761010177 G4 box; other site 698761010178 G5 box; other site 698761010179 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698761010180 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698761010181 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761010182 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 698761010183 C-terminal domain interface [polypeptide binding]; other site 698761010184 GSH binding site (G-site) [chemical binding]; other site 698761010185 dimer interface [polypeptide binding]; other site 698761010186 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 698761010187 N-terminal domain interface [polypeptide binding]; other site 698761010188 dimer interface [polypeptide binding]; other site 698761010189 substrate binding pocket (H-site) [chemical binding]; other site 698761010190 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761010191 MarR family; Region: MarR_2; pfam12802 698761010192 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698761010193 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698761010194 active site 698761010195 Zn binding site [ion binding]; other site 698761010196 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761010197 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761010198 MarR family; Region: MarR_2; pfam12802 698761010199 argininosuccinate synthase; Provisional; Region: PRK13820 698761010200 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698761010201 ANP binding site [chemical binding]; other site 698761010202 Substrate Binding Site II [chemical binding]; other site 698761010203 Substrate Binding Site I [chemical binding]; other site 698761010204 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 698761010205 classical (c) SDRs; Region: SDR_c; cd05233 698761010206 NAD(P) binding site [chemical binding]; other site 698761010207 active site 698761010208 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761010209 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 698761010210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761010211 FeS/SAM binding site; other site 698761010212 Uncharacterized conserved protein [Function unknown]; Region: COG3339 698761010213 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 698761010214 aromatic arch; other site 698761010215 DCoH dimer interaction site [polypeptide binding]; other site 698761010216 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 698761010217 DCoH tetramer interaction site [polypeptide binding]; other site 698761010218 substrate binding site [chemical binding]; other site 698761010219 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 698761010220 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 698761010221 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 698761010222 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 698761010223 active site 698761010224 catalytic triad [active] 698761010225 oxyanion hole [active] 698761010226 switch loop; other site 698761010227 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 698761010228 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698761010229 Walker A/P-loop; other site 698761010230 ATP binding site [chemical binding]; other site 698761010231 Q-loop/lid; other site 698761010232 ABC transporter signature motif; other site 698761010233 Walker B; other site 698761010234 D-loop; other site 698761010235 H-loop/switch region; other site 698761010236 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 698761010237 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698761010238 FtsX-like permease family; Region: FtsX; pfam02687 698761010239 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 698761010240 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 698761010241 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698761010242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761010243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761010244 Coenzyme A binding pocket [chemical binding]; other site 698761010245 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 698761010246 Uncharacterized secreted protein [Function unknown]; Region: COG5429 698761010247 aconitate hydratase; Validated; Region: PRK09277 698761010248 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 698761010249 substrate binding site [chemical binding]; other site 698761010250 ligand binding site [chemical binding]; other site 698761010251 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698761010252 substrate binding site [chemical binding]; other site 698761010253 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 698761010254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761010255 Walker A/P-loop; other site 698761010256 ATP binding site [chemical binding]; other site 698761010257 Q-loop/lid; other site 698761010258 ABC transporter signature motif; other site 698761010259 Walker B; other site 698761010260 D-loop; other site 698761010261 H-loop/switch region; other site 698761010262 heme exporter protein CcmB; Region: ccmB; TIGR01190 698761010263 heme exporter protein CcmC; Region: ccmC; TIGR01191 698761010264 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 698761010265 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 698761010266 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 698761010267 catalytic residues [active] 698761010268 central insert; other site 698761010269 hypothetical protein; Provisional; Region: PRK00944 698761010270 intracellular septation protein A; Reviewed; Region: PRK00259 698761010271 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698761010272 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698761010273 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698761010274 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 698761010275 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698761010276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761010277 FeS/SAM binding site; other site 698761010278 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 698761010279 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698761010280 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698761010281 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 698761010282 putative hydrophobic ligand binding site [chemical binding]; other site 698761010283 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698761010284 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 698761010285 signal recognition particle protein; Provisional; Region: PRK10867 698761010286 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698761010287 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698761010288 P loop; other site 698761010289 GTP binding site [chemical binding]; other site 698761010290 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698761010291 chorismate mutase; Provisional; Region: PRK09239 698761010292 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 698761010293 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698761010294 RimM N-terminal domain; Region: RimM; pfam01782 698761010295 PRC-barrel domain; Region: PRC; pfam05239 698761010296 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698761010297 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 698761010298 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698761010299 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698761010300 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698761010301 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761010302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761010303 substrate binding pocket [chemical binding]; other site 698761010304 membrane-bound complex binding site; other site 698761010305 hinge residues; other site 698761010306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010307 dimer interface [polypeptide binding]; other site 698761010308 conserved gate region; other site 698761010309 putative PBP binding loops; other site 698761010310 ABC-ATPase subunit interface; other site 698761010311 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698761010312 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698761010313 substrate binding site [chemical binding]; other site 698761010314 ligand binding site [chemical binding]; other site 698761010315 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 698761010316 EamA-like transporter family; Region: EamA; cl17759 698761010317 EamA-like transporter family; Region: EamA; pfam00892 698761010318 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761010319 MarR family; Region: MarR; pfam01047 698761010320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761010321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761010322 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 698761010323 putative substrate binding pocket [chemical binding]; other site 698761010324 putative dimerization interface [polypeptide binding]; other site 698761010325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761010326 putative substrate translocation pore; other site 698761010327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761010328 transcriptional regulator; Provisional; Region: PRK10632 698761010329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761010330 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 698761010331 putative effector binding pocket; other site 698761010332 putative dimerization interface [polypeptide binding]; other site 698761010333 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 698761010334 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698761010335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761010336 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761010337 active site 698761010338 catalytic tetrad [active] 698761010339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 698761010340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761010341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761010342 active site 698761010343 phosphorylation site [posttranslational modification] 698761010344 intermolecular recognition site; other site 698761010345 dimerization interface [polypeptide binding]; other site 698761010346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761010347 DNA binding site [nucleotide binding] 698761010348 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698761010349 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761010350 ligand binding site [chemical binding]; other site 698761010351 flexible hinge region; other site 698761010352 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 698761010353 putative catalytic site [active] 698761010354 putative phosphate binding site [ion binding]; other site 698761010355 active site 698761010356 metal binding site A [ion binding]; metal-binding site 698761010357 DNA binding site [nucleotide binding] 698761010358 putative AP binding site [nucleotide binding]; other site 698761010359 putative metal binding site B [ion binding]; other site 698761010360 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 698761010361 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 698761010362 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 698761010363 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698761010364 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698761010365 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698761010366 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 698761010367 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 698761010368 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698761010369 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698761010370 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698761010371 active site 698761010372 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698761010373 catalytic triad [active] 698761010374 dimer interface [polypeptide binding]; other site 698761010375 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 698761010376 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761010377 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761010378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761010379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761010380 dimerization interface [polypeptide binding]; other site 698761010381 Uncharacterized conserved protein [Function unknown]; Region: COG2835 698761010382 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 698761010383 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698761010384 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698761010385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761010386 TPR motif; other site 698761010387 binding surface 698761010388 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 698761010389 putative deacylase active site [active] 698761010390 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 698761010391 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698761010392 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698761010393 active site 698761010394 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 698761010395 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698761010396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698761010397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761010398 S-adenosylmethionine binding site [chemical binding]; other site 698761010399 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 698761010400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 698761010401 Esterase/lipase [General function prediction only]; Region: COG1647 698761010402 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 698761010403 Fatty acid desaturase; Region: FA_desaturase; pfam00487 698761010404 putative di-iron ligands [ion binding]; other site 698761010405 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 698761010406 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 698761010407 active site 698761010408 metal binding site [ion binding]; metal-binding site 698761010409 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761010410 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 698761010411 inhibitor-cofactor binding pocket; inhibition site 698761010412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761010413 catalytic residue [active] 698761010414 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698761010415 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 698761010416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761010417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761010418 dimer interface [polypeptide binding]; other site 698761010419 phosphorylation site [posttranslational modification] 698761010420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761010421 ATP binding site [chemical binding]; other site 698761010422 Mg2+ binding site [ion binding]; other site 698761010423 G-X-G motif; other site 698761010424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761010425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761010426 active site 698761010427 phosphorylation site [posttranslational modification] 698761010428 intermolecular recognition site; other site 698761010429 dimerization interface [polypeptide binding]; other site 698761010430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761010431 DNA binding site [nucleotide binding] 698761010432 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761010433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761010434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761010435 dimerization interface [polypeptide binding]; other site 698761010436 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 698761010437 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761010438 putative metal binding site [ion binding]; other site 698761010439 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698761010440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761010441 DNA-binding site [nucleotide binding]; DNA binding site 698761010442 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761010443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761010444 homodimer interface [polypeptide binding]; other site 698761010445 catalytic residue [active] 698761010446 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761010447 EamA-like transporter family; Region: EamA; pfam00892 698761010448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 698761010449 SnoaL-like domain; Region: SnoaL_2; pfam12680 698761010450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761010451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761010452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 698761010453 Putative glucoamylase; Region: Glycoamylase; pfam10091 698761010454 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 698761010455 aldehyde dehydrogenase family 7 member; Region: PLN02315 698761010456 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 698761010457 tetrameric interface [polypeptide binding]; other site 698761010458 NAD binding site [chemical binding]; other site 698761010459 catalytic residues [active] 698761010460 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698761010461 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761010462 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761010463 AsnC family; Region: AsnC_trans_reg; pfam01037 698761010464 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761010465 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698761010466 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698761010467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698761010468 active site 698761010469 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 698761010470 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698761010471 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698761010472 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 698761010473 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 698761010474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761010475 active site 698761010476 phosphorylation site [posttranslational modification] 698761010477 intermolecular recognition site; other site 698761010478 dimerization interface [polypeptide binding]; other site 698761010479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761010480 DNA binding site [nucleotide binding] 698761010481 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 698761010482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761010483 HAMP domain; Region: HAMP; pfam00672 698761010484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761010485 dimer interface [polypeptide binding]; other site 698761010486 phosphorylation site [posttranslational modification] 698761010487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761010488 ATP binding site [chemical binding]; other site 698761010489 Mg2+ binding site [ion binding]; other site 698761010490 G-X-G motif; other site 698761010491 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761010492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010493 dimer interface [polypeptide binding]; other site 698761010494 conserved gate region; other site 698761010495 putative PBP binding loops; other site 698761010496 ABC-ATPase subunit interface; other site 698761010497 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761010498 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761010499 Walker A/P-loop; other site 698761010500 ATP binding site [chemical binding]; other site 698761010501 Q-loop/lid; other site 698761010502 ABC transporter signature motif; other site 698761010503 Walker B; other site 698761010504 D-loop; other site 698761010505 H-loop/switch region; other site 698761010506 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 698761010507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 698761010508 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 698761010509 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 698761010510 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761010511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761010512 non-specific DNA binding site [nucleotide binding]; other site 698761010513 salt bridge; other site 698761010514 sequence-specific DNA binding site [nucleotide binding]; other site 698761010515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761010516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761010517 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 698761010518 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761010519 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761010520 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 698761010521 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 698761010522 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698761010523 oligomeric interface; other site 698761010524 putative active site [active] 698761010525 homodimer interface [polypeptide binding]; other site 698761010526 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 698761010527 Protein export membrane protein; Region: SecD_SecF; cl14618 698761010528 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 698761010529 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761010530 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698761010531 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761010532 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 698761010533 HTH DNA binding domain; Region: HTH_13; pfam11972 698761010534 YHS domain; Region: YHS; pfam04945 698761010535 YHS domain; Region: YHS; pfam04945 698761010536 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 698761010537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698761010538 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698761010539 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 698761010540 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698761010541 dimer interface [polypeptide binding]; other site 698761010542 active site 698761010543 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 698761010544 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 698761010545 putative active site [active] 698761010546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761010547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761010548 putative substrate translocation pore; other site 698761010549 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 698761010550 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 698761010551 Moco binding site; other site 698761010552 metal coordination site [ion binding]; other site 698761010553 HutD; Region: HutD; pfam05962 698761010554 urocanate hydratase; Provisional; Region: PRK05414 698761010555 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 698761010556 active sites [active] 698761010557 tetramer interface [polypeptide binding]; other site 698761010558 imidazolonepropionase; Validated; Region: PRK09356 698761010559 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 698761010560 active site 698761010561 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 698761010562 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 698761010563 active site 698761010564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761010565 DNA-binding site [nucleotide binding]; DNA binding site 698761010566 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 698761010567 UTRA domain; Region: UTRA; pfam07702 698761010568 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 698761010569 generic binding surface I; other site 698761010570 manganese transport protein MntH; Reviewed; Region: PRK00701 698761010571 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 698761010572 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 698761010573 Peptidase family M23; Region: Peptidase_M23; pfam01551 698761010574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761010575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761010576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 698761010577 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761010578 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761010579 Walker A/P-loop; other site 698761010580 ATP binding site [chemical binding]; other site 698761010581 Q-loop/lid; other site 698761010582 ABC transporter signature motif; other site 698761010583 Walker B; other site 698761010584 D-loop; other site 698761010585 H-loop/switch region; other site 698761010586 TOBE domain; Region: TOBE_2; pfam08402 698761010587 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761010588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010589 dimer interface [polypeptide binding]; other site 698761010590 conserved gate region; other site 698761010591 putative PBP binding loops; other site 698761010592 ABC-ATPase subunit interface; other site 698761010593 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761010594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010595 dimer interface [polypeptide binding]; other site 698761010596 conserved gate region; other site 698761010597 putative PBP binding loops; other site 698761010598 ABC-ATPase subunit interface; other site 698761010599 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761010600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761010601 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698761010602 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761010603 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761010604 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761010605 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761010606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 698761010607 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 698761010608 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 698761010609 Cl binding site [ion binding]; other site 698761010610 oligomer interface [polypeptide binding]; other site 698761010611 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761010612 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698761010613 Walker A/P-loop; other site 698761010614 ATP binding site [chemical binding]; other site 698761010615 Q-loop/lid; other site 698761010616 ABC transporter signature motif; other site 698761010617 Walker B; other site 698761010618 D-loop; other site 698761010619 H-loop/switch region; other site 698761010620 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761010621 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 698761010622 Walker A/P-loop; other site 698761010623 ATP binding site [chemical binding]; other site 698761010624 Q-loop/lid; other site 698761010625 ABC transporter signature motif; other site 698761010626 Walker B; other site 698761010627 D-loop; other site 698761010628 H-loop/switch region; other site 698761010629 TOBE domain; Region: TOBE_2; pfam08402 698761010630 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698761010631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010632 dimer interface [polypeptide binding]; other site 698761010633 conserved gate region; other site 698761010634 putative PBP binding loops; other site 698761010635 ABC-ATPase subunit interface; other site 698761010636 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761010637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010638 dimer interface [polypeptide binding]; other site 698761010639 conserved gate region; other site 698761010640 putative PBP binding loops; other site 698761010641 ABC-ATPase subunit interface; other site 698761010642 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 698761010643 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761010644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761010645 active site 698761010646 motif I; other site 698761010647 motif II; other site 698761010648 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761010649 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761010650 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761010651 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698761010652 ligand binding site [chemical binding]; other site 698761010653 dimerization interface [polypeptide binding]; other site 698761010654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 698761010655 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 698761010656 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698761010657 putative ligand binding site [chemical binding]; other site 698761010658 putative NAD binding site [chemical binding]; other site 698761010659 catalytic site [active] 698761010660 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698761010661 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698761010662 catalytic residue [active] 698761010663 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761010664 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761010665 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761010666 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 698761010667 metal binding site [ion binding]; metal-binding site 698761010668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761010669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761010670 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761010671 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761010672 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698761010673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010674 putative PBP binding loops; other site 698761010675 ABC-ATPase subunit interface; other site 698761010676 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761010677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010678 dimer interface [polypeptide binding]; other site 698761010679 conserved gate region; other site 698761010680 putative PBP binding loops; other site 698761010681 ABC-ATPase subunit interface; other site 698761010682 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761010683 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761010684 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761010685 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761010686 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761010687 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761010688 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761010689 Walker A/P-loop; other site 698761010690 ATP binding site [chemical binding]; other site 698761010691 Q-loop/lid; other site 698761010692 ABC transporter signature motif; other site 698761010693 Walker B; other site 698761010694 D-loop; other site 698761010695 H-loop/switch region; other site 698761010696 TOBE domain; Region: TOBE_2; pfam08402 698761010697 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 698761010698 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698761010699 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 698761010700 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 698761010701 dimer interface [polypeptide binding]; other site 698761010702 motif 1; other site 698761010703 active site 698761010704 motif 2; other site 698761010705 motif 3; other site 698761010706 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761010707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761010708 active site 698761010709 acyl carrier protein; Provisional; Region: PRK07081 698761010710 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 698761010711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761010712 FeS/SAM binding site; other site 698761010713 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 698761010714 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698761010715 motif 1; other site 698761010716 dimer interface [polypeptide binding]; other site 698761010717 active site 698761010718 motif 2; other site 698761010719 motif 3; other site 698761010720 elongation factor P; Validated; Region: PRK00529 698761010721 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698761010722 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698761010723 RNA binding site [nucleotide binding]; other site 698761010724 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698761010725 RNA binding site [nucleotide binding]; other site 698761010726 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 698761010727 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 698761010728 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 698761010729 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698761010730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761010731 Walker A motif; other site 698761010732 ATP binding site [chemical binding]; other site 698761010733 Walker B motif; other site 698761010734 arginine finger; other site 698761010735 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698761010736 nudix motif; other site 698761010737 homoserine O-succinyltransferase; Provisional; Region: PRK05368 698761010738 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 698761010739 proposed active site lysine [active] 698761010740 conserved cys residue [active] 698761010741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 698761010742 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 698761010743 active site 698761010744 catalytic residues [active] 698761010745 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698761010746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761010747 DNA-binding site [nucleotide binding]; DNA binding site 698761010748 UTRA domain; Region: UTRA; pfam07702 698761010749 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 698761010750 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698761010751 dimer interface [polypeptide binding]; other site 698761010752 active site 698761010753 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698761010754 dimer interface [polypeptide binding]; other site 698761010755 active site 698761010756 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698761010757 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698761010758 active site 698761010759 dimer interface [polypeptide binding]; other site 698761010760 hypothetical protein; Provisional; Region: PRK02947 698761010761 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698761010762 putative active site [active] 698761010763 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698761010764 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761010765 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761010766 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761010767 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698761010768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761010769 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698761010770 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 698761010771 Thiamine pyrophosphokinase; Region: TPK; cd07995 698761010772 active site 698761010773 dimerization interface [polypeptide binding]; other site 698761010774 thiamine binding site [chemical binding]; other site 698761010775 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761010776 MarR family; Region: MarR_2; pfam12802 698761010777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761010778 putative substrate translocation pore; other site 698761010779 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 698761010780 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 698761010781 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 698761010782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010783 dimer interface [polypeptide binding]; other site 698761010784 conserved gate region; other site 698761010785 putative PBP binding loops; other site 698761010786 ABC-ATPase subunit interface; other site 698761010787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010788 dimer interface [polypeptide binding]; other site 698761010789 conserved gate region; other site 698761010790 putative PBP binding loops; other site 698761010791 ABC-ATPase subunit interface; other site 698761010792 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 698761010793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761010794 Walker A/P-loop; other site 698761010795 ATP binding site [chemical binding]; other site 698761010796 Q-loop/lid; other site 698761010797 ABC transporter signature motif; other site 698761010798 Walker B; other site 698761010799 D-loop; other site 698761010800 H-loop/switch region; other site 698761010801 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 698761010802 Peptidase family M48; Region: Peptidase_M48; pfam01435 698761010803 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698761010804 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 698761010805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761010806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761010807 DNA binding residues [nucleotide binding] 698761010808 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 698761010809 Ferredoxin [Energy production and conversion]; Region: COG1146 698761010810 4Fe-4S binding domain; Region: Fer4; cl02805 698761010811 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 698761010812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698761010813 RNA binding surface [nucleotide binding]; other site 698761010814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698761010815 ATP binding site [chemical binding]; other site 698761010816 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698761010817 putative Mg++ binding site [ion binding]; other site 698761010818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698761010819 nucleotide binding region [chemical binding]; other site 698761010820 ATP-binding site [chemical binding]; other site 698761010821 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 698761010822 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 698761010823 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 698761010824 NAD(P) binding site [chemical binding]; other site 698761010825 homotetramer interface [polypeptide binding]; other site 698761010826 homodimer interface [polypeptide binding]; other site 698761010827 active site 698761010828 putative acyltransferase; Provisional; Region: PRK05790 698761010829 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698761010830 dimer interface [polypeptide binding]; other site 698761010831 active site 698761010832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 698761010833 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 698761010834 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 698761010835 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 698761010836 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761010837 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 698761010838 putative C-terminal domain interface [polypeptide binding]; other site 698761010839 putative GSH binding site (G-site) [chemical binding]; other site 698761010840 putative dimer interface [polypeptide binding]; other site 698761010841 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 698761010842 putative N-terminal domain interface [polypeptide binding]; other site 698761010843 putative dimer interface [polypeptide binding]; other site 698761010844 putative substrate binding pocket (H-site) [chemical binding]; other site 698761010845 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 698761010846 Transglycosylase; Region: Transgly; cl17702 698761010847 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698761010848 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698761010849 substrate binding pocket [chemical binding]; other site 698761010850 chain length determination region; other site 698761010851 substrate-Mg2+ binding site; other site 698761010852 catalytic residues [active] 698761010853 aspartate-rich region 1; other site 698761010854 active site lid residues [active] 698761010855 aspartate-rich region 2; other site 698761010856 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761010857 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698761010858 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698761010859 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698761010860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761010861 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761010862 putative substrate translocation pore; other site 698761010863 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761010864 EamA-like transporter family; Region: EamA; pfam00892 698761010865 EamA-like transporter family; Region: EamA; cl17759 698761010866 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698761010867 Beta-lactamase; Region: Beta-lactamase; pfam00144 698761010868 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 698761010869 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761010870 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 698761010871 active site 698761010872 catalytic triad [active] 698761010873 oxyanion hole [active] 698761010874 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761010875 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761010876 substrate binding pocket [chemical binding]; other site 698761010877 membrane-bound complex binding site; other site 698761010878 hinge residues; other site 698761010879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010880 dimer interface [polypeptide binding]; other site 698761010881 conserved gate region; other site 698761010882 putative PBP binding loops; other site 698761010883 ABC-ATPase subunit interface; other site 698761010884 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761010885 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761010886 Walker A/P-loop; other site 698761010887 ATP binding site [chemical binding]; other site 698761010888 Q-loop/lid; other site 698761010889 ABC transporter signature motif; other site 698761010890 Walker B; other site 698761010891 D-loop; other site 698761010892 H-loop/switch region; other site 698761010893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761010894 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761010895 putative substrate translocation pore; other site 698761010896 pyruvate carboxylase; Reviewed; Region: PRK12999 698761010897 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698761010898 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698761010899 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698761010900 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698761010901 active site 698761010902 catalytic residues [active] 698761010903 metal binding site [ion binding]; metal-binding site 698761010904 homodimer binding site [polypeptide binding]; other site 698761010905 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698761010906 carboxyltransferase (CT) interaction site; other site 698761010907 biotinylation site [posttranslational modification]; other site 698761010908 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 698761010909 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698761010910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761010911 DNA binding residues [nucleotide binding] 698761010912 dimerization interface [polypeptide binding]; other site 698761010913 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 698761010914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761010915 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 698761010916 Walker A/P-loop; other site 698761010917 ATP binding site [chemical binding]; other site 698761010918 Q-loop/lid; other site 698761010919 ABC transporter signature motif; other site 698761010920 Walker B; other site 698761010921 D-loop; other site 698761010922 H-loop/switch region; other site 698761010923 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698761010924 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761010925 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698761010926 OpgC protein; Region: OpgC_C; cl17858 698761010927 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698761010928 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 698761010929 Putative glucoamylase; Region: Glycoamylase; pfam10091 698761010930 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 698761010931 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 698761010932 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 698761010933 Protein of unknown function, DUF608; Region: DUF608; pfam04685 698761010934 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698761010935 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761010936 Walker A/P-loop; other site 698761010937 ATP binding site [chemical binding]; other site 698761010938 Q-loop/lid; other site 698761010939 ABC transporter signature motif; other site 698761010940 Walker B; other site 698761010941 D-loop; other site 698761010942 H-loop/switch region; other site 698761010943 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698761010944 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761010945 Walker A/P-loop; other site 698761010946 ATP binding site [chemical binding]; other site 698761010947 Q-loop/lid; other site 698761010948 ABC transporter signature motif; other site 698761010949 Walker B; other site 698761010950 D-loop; other site 698761010951 H-loop/switch region; other site 698761010952 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761010953 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698761010954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010955 dimer interface [polypeptide binding]; other site 698761010956 conserved gate region; other site 698761010957 ABC-ATPase subunit interface; other site 698761010958 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761010959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761010960 dimer interface [polypeptide binding]; other site 698761010961 conserved gate region; other site 698761010962 putative PBP binding loops; other site 698761010963 ABC-ATPase subunit interface; other site 698761010964 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761010965 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 698761010966 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 698761010967 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 698761010968 active site 698761010969 dimer interface [polypeptide binding]; other site 698761010970 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761010971 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761010972 TM-ABC transporter signature motif; other site 698761010973 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761010974 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761010975 Walker A/P-loop; other site 698761010976 ATP binding site [chemical binding]; other site 698761010977 Q-loop/lid; other site 698761010978 ABC transporter signature motif; other site 698761010979 Walker B; other site 698761010980 D-loop; other site 698761010981 H-loop/switch region; other site 698761010982 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761010983 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761010984 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 698761010985 putative ligand binding site [chemical binding]; other site 698761010986 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 698761010987 Sulfatase; Region: Sulfatase; cl17466 698761010988 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 698761010989 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698761010990 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698761010991 NAD binding site [chemical binding]; other site 698761010992 homodimer interface [polypeptide binding]; other site 698761010993 active site 698761010994 substrate binding site [chemical binding]; other site 698761010995 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 698761010996 Predicted periplasmic protein [Function unknown]; Region: COG3904 698761010997 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 698761010998 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698761010999 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698761011000 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 698761011001 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761011002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761011003 NAD(P) binding site [chemical binding]; other site 698761011004 active site 698761011005 Bacterial sugar transferase; Region: Bac_transf; pfam02397 698761011006 O-Antigen ligase; Region: Wzy_C; pfam04932 698761011007 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 698761011008 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 698761011009 metal-binding site 698761011010 putative glycosyl transferase; Provisional; Region: PRK10018 698761011011 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 698761011012 metal-binding site 698761011013 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698761011014 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698761011015 Walker A/P-loop; other site 698761011016 ATP binding site [chemical binding]; other site 698761011017 Q-loop/lid; other site 698761011018 ABC transporter signature motif; other site 698761011019 Walker B; other site 698761011020 D-loop; other site 698761011021 H-loop/switch region; other site 698761011022 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 698761011023 putative carbohydrate binding site [chemical binding]; other site 698761011024 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698761011025 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698761011026 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761011027 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698761011028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761011029 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698761011030 NAD(P) binding site [chemical binding]; other site 698761011031 active site 698761011032 putative glycosyl transferase; Provisional; Region: PRK10073 698761011033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698761011034 active site 698761011035 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698761011036 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 698761011037 trimer interface [polypeptide binding]; other site 698761011038 active site 698761011039 substrate binding site [chemical binding]; other site 698761011040 CoA binding site [chemical binding]; other site 698761011041 Methyltransferase domain; Region: Methyltransf_23; pfam13489 698761011042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761011043 S-adenosylmethionine binding site [chemical binding]; other site 698761011044 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 698761011045 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698761011046 metal-binding site 698761011047 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 698761011048 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 698761011049 NADP binding site [chemical binding]; other site 698761011050 active site 698761011051 putative substrate binding site [chemical binding]; other site 698761011052 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 698761011053 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 698761011054 NADP-binding site; other site 698761011055 homotetramer interface [polypeptide binding]; other site 698761011056 substrate binding site [chemical binding]; other site 698761011057 homodimer interface [polypeptide binding]; other site 698761011058 active site 698761011059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761011060 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 698761011061 putative ADP-binding pocket [chemical binding]; other site 698761011062 Cupin domain; Region: Cupin_2; cl17218 698761011063 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 698761011064 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698761011065 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698761011066 substrate binding site; other site 698761011067 tetramer interface; other site 698761011068 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 698761011069 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698761011070 NADP binding site [chemical binding]; other site 698761011071 active site 698761011072 putative substrate binding site [chemical binding]; other site 698761011073 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698761011074 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698761011075 NAD binding site [chemical binding]; other site 698761011076 substrate binding site [chemical binding]; other site 698761011077 homodimer interface [polypeptide binding]; other site 698761011078 active site 698761011079 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 698761011080 RNA polymerase sigma factor; Provisional; Region: PRK12512 698761011081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761011082 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 698761011083 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 698761011084 hypothetical protein; Provisional; Region: PRK05409 698761011085 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 698761011086 Predicted membrane protein [Function unknown]; Region: COG2259 698761011087 Predicted membrane protein [Function unknown]; Region: COG4420 698761011088 haemagglutination activity domain; Region: Haemagg_act; pfam05860 698761011089 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 698761011090 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 698761011091 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 698761011092 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 698761011093 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 698761011094 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 698761011095 Cupin domain; Region: Cupin_2; pfam07883 698761011096 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698761011097 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698761011098 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698761011099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761011100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761011101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761011102 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761011103 GTPase CgtA; Reviewed; Region: obgE; PRK12299 698761011104 GTP1/OBG; Region: GTP1_OBG; pfam01018 698761011105 Obg GTPase; Region: Obg; cd01898 698761011106 G1 box; other site 698761011107 GTP/Mg2+ binding site [chemical binding]; other site 698761011108 Switch I region; other site 698761011109 G2 box; other site 698761011110 G3 box; other site 698761011111 Switch II region; other site 698761011112 G4 box; other site 698761011113 G5 box; other site 698761011114 gamma-glutamyl kinase; Provisional; Region: PRK05429 698761011115 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698761011116 nucleotide binding site [chemical binding]; other site 698761011117 homotetrameric interface [polypeptide binding]; other site 698761011118 putative phosphate binding site [ion binding]; other site 698761011119 putative allosteric binding site; other site 698761011120 PUA domain; Region: PUA; pfam01472 698761011121 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698761011122 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698761011123 putative catalytic cysteine [active] 698761011124 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698761011125 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 698761011126 active site 698761011127 (T/H)XGH motif; other site 698761011128 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 698761011129 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761011130 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698761011131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761011132 dimer interface [polypeptide binding]; other site 698761011133 conserved gate region; other site 698761011134 putative PBP binding loops; other site 698761011135 ABC-ATPase subunit interface; other site 698761011136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761011137 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698761011138 Walker A/P-loop; other site 698761011139 ATP binding site [chemical binding]; other site 698761011140 Q-loop/lid; other site 698761011141 ABC transporter signature motif; other site 698761011142 Walker B; other site 698761011143 D-loop; other site 698761011144 H-loop/switch region; other site 698761011145 TOBE domain; Region: TOBE; cl01440 698761011146 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 698761011147 Uncharacterized conserved protein [Function unknown]; Region: COG5470 698761011148 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 698761011149 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 698761011150 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 698761011151 Peptidase family M23; Region: Peptidase_M23; pfam01551 698761011152 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 698761011153 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 698761011154 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 698761011155 protein binding site [polypeptide binding]; other site 698761011156 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 698761011157 Catalytic dyad [active] 698761011158 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 698761011159 NodB motif; other site 698761011160 putative active site [active] 698761011161 putative catalytic site [active] 698761011162 Zn binding site [ion binding]; other site 698761011163 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 698761011164 putative active site [active] 698761011165 Ap4A binding site [chemical binding]; other site 698761011166 nudix motif; other site 698761011167 putative metal binding site [ion binding]; other site 698761011168 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 698761011169 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 698761011170 heme binding site [chemical binding]; other site 698761011171 ferroxidase pore; other site 698761011172 ferroxidase diiron center [ion binding]; other site 698761011173 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698761011174 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 698761011175 putative active site [active] 698761011176 putative PHP Thumb interface [polypeptide binding]; other site 698761011177 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698761011178 generic binding surface II; other site 698761011179 generic binding surface I; other site 698761011180 DNA Polymerase Y-family; Region: PolY_like; cd03468 698761011181 active site 698761011182 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 698761011183 DNA binding site [nucleotide binding] 698761011184 Uncharacterized conserved protein [Function unknown]; Region: COG4544 698761011185 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 698761011186 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 698761011187 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 698761011188 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698761011189 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698761011190 substrate binding site [chemical binding]; other site 698761011191 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698761011192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761011193 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698761011194 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698761011195 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698761011196 Metal-binding active site; metal-binding site 698761011197 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 698761011198 tartrate dehydrogenase; Region: TTC; TIGR02089 698761011199 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 698761011200 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698761011201 active site 698761011202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761011203 putative DNA binding site [nucleotide binding]; other site 698761011204 putative Zn2+ binding site [ion binding]; other site 698761011205 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698761011206 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 698761011207 NADP binding site [chemical binding]; other site 698761011208 homodimer interface [polypeptide binding]; other site 698761011209 active site 698761011210 substrate binding site [chemical binding]; other site 698761011211 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698761011212 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698761011213 dimerization interface [polypeptide binding]; other site 698761011214 DPS ferroxidase diiron center [ion binding]; other site 698761011215 ion pore; other site 698761011216 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698761011217 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698761011218 Transglycosylase SLT domain; Region: SLT_2; pfam13406 698761011219 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698761011220 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698761011221 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 698761011222 active site clefts [active] 698761011223 zinc binding site [ion binding]; other site 698761011224 dimer interface [polypeptide binding]; other site 698761011225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 698761011226 acetyl-CoA synthetase; Provisional; Region: PRK00174 698761011227 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 698761011228 active site 698761011229 CoA binding site [chemical binding]; other site 698761011230 acyl-activating enzyme (AAE) consensus motif; other site 698761011231 AMP binding site [chemical binding]; other site 698761011232 acetate binding site [chemical binding]; other site 698761011233 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 698761011234 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 698761011235 heat shock protein HtpX; Provisional; Region: PRK01345 698761011236 NusB family; Region: NusB; pfam01029 698761011237 putative RNA binding site [nucleotide binding]; other site 698761011238 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 698761011239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761011240 S-adenosylmethionine binding site [chemical binding]; other site 698761011241 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 698761011242 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698761011243 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698761011244 purine monophosphate binding site [chemical binding]; other site 698761011245 dimer interface [polypeptide binding]; other site 698761011246 putative catalytic residues [active] 698761011247 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698761011248 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 698761011249 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 698761011250 pyridoxamine kinase; Validated; Region: PRK05756 698761011251 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698761011252 pyridoxal binding site [chemical binding]; other site 698761011253 dimer interface [polypeptide binding]; other site 698761011254 ATP binding site [chemical binding]; other site 698761011255 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698761011256 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698761011257 catalytic residue [active] 698761011258 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698761011259 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 698761011260 HIGH motif; other site 698761011261 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698761011262 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698761011263 active site 698761011264 KMSKS motif; other site 698761011265 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698761011266 tRNA binding surface [nucleotide binding]; other site 698761011267 Lipopolysaccharide-assembly; Region: LptE; cl01125 698761011268 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 698761011269 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698761011270 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 698761011271 ParB-like nuclease domain; Region: ParBc; pfam02195 698761011272 KorB domain; Region: KorB; pfam08535 698761011273 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698761011274 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698761011275 P-loop; other site 698761011276 Magnesium ion binding site [ion binding]; other site 698761011277 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698761011278 Magnesium ion binding site [ion binding]; other site 698761011279 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698761011280 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 698761011281 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 698761011282 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 698761011283 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 698761011284 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 698761011285 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 698761011286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761011287 ABC transporter signature motif; other site 698761011288 Walker B; other site 698761011289 trmE is a tRNA modification GTPase; Region: trmE; cd04164 698761011290 G1 box; other site 698761011291 GTP/Mg2+ binding site [chemical binding]; other site 698761011292 Switch I region; other site 698761011293 G2 box; other site 698761011294 Switch II region; other site 698761011295 G3 box; other site 698761011296 G4 box; other site 698761011297 G5 box; other site 698761011298 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 698761011299 transcription termination factor Rho; Provisional; Region: rho; PRK09376 698761011300 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 698761011301 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 698761011302 RNA binding site [nucleotide binding]; other site 698761011303 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698761011304 multimer interface [polypeptide binding]; other site 698761011305 Walker A motif; other site 698761011306 ATP binding site [chemical binding]; other site 698761011307 Walker B motif; other site 698761011308 Predicted membrane protein [Function unknown]; Region: COG1981 698761011309 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698761011310 substrate binding site [chemical binding]; other site 698761011311 active site 698761011312 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698761011313 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698761011314 catalytic residues [active] 698761011315 catalytic nucleophile [active] 698761011316 Presynaptic Site I dimer interface [polypeptide binding]; other site 698761011317 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698761011318 Synaptic Flat tetramer interface [polypeptide binding]; other site 698761011319 Synaptic Site I dimer interface [polypeptide binding]; other site 698761011320 DNA binding site [nucleotide binding] 698761011321 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 698761011322 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 698761011323 DNA binding site [nucleotide binding] 698761011324 dimer interface [polypeptide binding]; other site 698761011325 Int/Topo IB signature motif; other site 698761011326 active site 698761011327 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 698761011328 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 698761011329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761011330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761011331 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761011332 putative effector binding pocket; other site 698761011333 dimerization interface [polypeptide binding]; other site 698761011334 SnoaL-like domain; Region: SnoaL_2; pfam12680 698761011335 short chain dehydrogenase; Provisional; Region: PRK12937 698761011336 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 698761011337 NADP binding site [chemical binding]; other site 698761011338 homodimer interface [polypeptide binding]; other site 698761011339 active site 698761011340 substrate binding site [chemical binding]; other site 698761011341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761011342 NAD(P) binding site [chemical binding]; other site 698761011343 active site 698761011344 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761011345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761011346 putative substrate translocation pore; other site 698761011347 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698761011348 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698761011349 substrate binding pocket [chemical binding]; other site 698761011350 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761011351 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761011352 active site 698761011353 catalytic tetrad [active] 698761011354 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698761011355 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698761011356 putative active site [active] 698761011357 putative FMN binding site [chemical binding]; other site 698761011358 putative substrate binding site [chemical binding]; other site 698761011359 putative catalytic residue [active] 698761011360 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761011361 short chain dehydrogenase; Provisional; Region: PRK06180 698761011362 NADP binding site [chemical binding]; other site 698761011363 active site 698761011364 steroid binding site; other site 698761011365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761011366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761011367 WHG domain; Region: WHG; pfam13305 698761011368 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 698761011369 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698761011370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761011371 NAD(P) binding site [chemical binding]; other site 698761011372 active site 698761011373 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761011374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761011375 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 698761011376 metal-binding site 698761011377 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 698761011378 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698761011379 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761011380 catalytic loop [active] 698761011381 iron binding site [ion binding]; other site 698761011382 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698761011383 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698761011384 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698761011385 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698761011386 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698761011387 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761011388 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 698761011389 XdhC Rossmann domain; Region: XdhC_C; pfam13478 698761011390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761011391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761011392 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698761011393 putative effector binding pocket; other site 698761011394 putative dimerization interface [polypeptide binding]; other site 698761011395 TniQ; Region: TniQ; pfam06527 698761011396 Bacterial TniB protein; Region: TniB; pfam05621 698761011397 AAA domain; Region: AAA_22; pfam13401 698761011398 Integrase core domain; Region: rve; pfam00665 698761011399 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 698761011400 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 698761011401 HTH DNA binding domain; Region: HTH_13; pfam11972 698761011402 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698761011403 AAA domain; Region: AAA_23; pfam13476 698761011404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761011405 Walker A/P-loop; other site 698761011406 ATP binding site [chemical binding]; other site 698761011407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 698761011408 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 698761011409 Restriction endonuclease; Region: Mrr_cat; pfam04471 698761011410 Predicted ATPase [General function prediction only]; Region: COG4637 698761011411 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 698761011412 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 698761011413 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 698761011414 putative active site [active] 698761011415 putative metal-binding site [ion binding]; other site 698761011416 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698761011417 Part of AAA domain; Region: AAA_19; pfam13245 698761011418 Family description; Region: UvrD_C_2; pfam13538 698761011419 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698761011420 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698761011421 FMN binding site [chemical binding]; other site 698761011422 active site 698761011423 substrate binding site [chemical binding]; other site 698761011424 catalytic residue [active] 698761011425 short chain dehydrogenase; Validated; Region: PRK08264 698761011426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761011427 NAD(P) binding site [chemical binding]; other site 698761011428 active site 698761011429 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698761011430 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 698761011431 putative NAD(P) binding site [chemical binding]; other site 698761011432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761011433 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698761011434 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 698761011435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761011436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761011437 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698761011438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761011439 putative substrate translocation pore; other site 698761011440 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698761011441 classical (c) SDRs; Region: SDR_c; cd05233 698761011442 NAD(P) binding site [chemical binding]; other site 698761011443 active site 698761011444 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 698761011445 aspartate racemase; Region: asp_race; TIGR00035 698761011446 short chain dehydrogenase; Provisional; Region: PRK06180 698761011447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761011448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761011449 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 698761011450 Chorismate mutase type II; Region: CM_2; cl00693 698761011451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761011452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761011453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698761011454 dimerization interface [polypeptide binding]; other site 698761011455 short chain dehydrogenase; Provisional; Region: PRK06180 698761011456 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761011457 NADP binding site [chemical binding]; other site 698761011458 active site 698761011459 steroid binding site; other site 698761011460 Epoxide hydrolase N terminus; Region: EHN; pfam06441 698761011461 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761011462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761011463 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698761011464 active site 698761011465 metal binding site [ion binding]; metal-binding site 698761011466 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761011467 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761011468 MULE transposase domain; Region: MULE; pfam10551 698761011469 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698761011470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761011471 S-adenosylmethionine binding site [chemical binding]; other site 698761011472 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 698761011473 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 698761011474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761011475 Uncharacterized conserved protein [Function unknown]; Region: COG3496 698761011476 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698761011477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761011478 S-adenosylmethionine binding site [chemical binding]; other site 698761011479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 698761011480 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 698761011481 TspO/MBR family; Region: TspO_MBR; pfam03073 698761011482 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698761011483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761011484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761011485 DNA binding residues [nucleotide binding] 698761011486 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 698761011487 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 698761011488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761011489 PAS domain; Region: PAS_9; pfam13426 698761011490 putative active site [active] 698761011491 heme pocket [chemical binding]; other site 698761011492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698761011493 Histidine kinase; Region: HisKA_2; pfam07568 698761011494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761011495 Response regulator receiver domain; Region: Response_reg; pfam00072 698761011496 active site 698761011497 phosphorylation site [posttranslational modification] 698761011498 intermolecular recognition site; other site 698761011499 dimerization interface [polypeptide binding]; other site 698761011500 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 698761011501 Protein export membrane protein; Region: SecD_SecF; cl14618 698761011502 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761011503 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761011504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761011505 NAD(P) binding site [chemical binding]; other site 698761011506 active site 698761011507 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 698761011508 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 698761011509 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 698761011510 GTP cyclohydrolase I; Provisional; Region: PLN03044 698761011511 active site 698761011512 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761011513 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761011514 metal binding site [ion binding]; metal-binding site 698761011515 active site 698761011516 I-site; other site 698761011517 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 698761011518 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698761011519 oligomeric interface; other site 698761011520 putative active site [active] 698761011521 homodimer interface [polypeptide binding]; other site 698761011522 sensor protein QseC; Provisional; Region: PRK10337 698761011523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761011524 dimer interface [polypeptide binding]; other site 698761011525 phosphorylation site [posttranslational modification] 698761011526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761011527 ATP binding site [chemical binding]; other site 698761011528 Mg2+ binding site [ion binding]; other site 698761011529 G-X-G motif; other site 698761011530 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761011531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761011532 active site 698761011533 phosphorylation site [posttranslational modification] 698761011534 intermolecular recognition site; other site 698761011535 dimerization interface [polypeptide binding]; other site 698761011536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761011537 DNA binding site [nucleotide binding] 698761011538 PsbP; Region: PsbP; cl03356 698761011539 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761011540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761011541 Walker A/P-loop; other site 698761011542 ATP binding site [chemical binding]; other site 698761011543 Q-loop/lid; other site 698761011544 ABC transporter signature motif; other site 698761011545 Walker B; other site 698761011546 D-loop; other site 698761011547 H-loop/switch region; other site 698761011548 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761011549 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698761011550 Walker A/P-loop; other site 698761011551 ATP binding site [chemical binding]; other site 698761011552 Q-loop/lid; other site 698761011553 ABC transporter signature motif; other site 698761011554 Walker B; other site 698761011555 D-loop; other site 698761011556 H-loop/switch region; other site 698761011557 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 698761011558 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 698761011559 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 698761011560 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 698761011561 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 698761011562 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 698761011563 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 698761011564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761011565 dimerization interface [polypeptide binding]; other site 698761011566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761011567 dimer interface [polypeptide binding]; other site 698761011568 phosphorylation site [posttranslational modification] 698761011569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761011570 ATP binding site [chemical binding]; other site 698761011571 Mg2+ binding site [ion binding]; other site 698761011572 G-X-G motif; other site 698761011573 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761011574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761011575 active site 698761011576 phosphorylation site [posttranslational modification] 698761011577 intermolecular recognition site; other site 698761011578 dimerization interface [polypeptide binding]; other site 698761011579 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761011580 DNA binding site [nucleotide binding] 698761011581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698761011582 Integrase core domain; Region: rve; pfam00665 698761011583 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698761011584 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 698761011585 Int/Topo IB signature motif; other site 698761011586 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698761011587 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 698761011588 active site 698761011589 DNA binding site [nucleotide binding] 698761011590 Int/Topo IB signature motif; other site 698761011591 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698761011592 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 698761011593 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 698761011594 Int/Topo IB signature motif; other site 698761011595 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 698761011596 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698761011597 putative NAD(P) binding site [chemical binding]; other site 698761011598 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 698761011599 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 698761011600 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761011601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761011602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761011603 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698761011604 putative effector binding pocket; other site 698761011605 putative dimerization interface [polypeptide binding]; other site 698761011606 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 698761011607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761011608 Walker A motif; other site 698761011609 ATP binding site [chemical binding]; other site 698761011610 Walker B motif; other site 698761011611 arginine finger; other site 698761011612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698761011613 Integrase core domain; Region: rve; pfam00665 698761011614 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761011615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761011616 DNA-binding site [nucleotide binding]; DNA binding site 698761011617 FCD domain; Region: FCD; pfam07729 698761011618 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761011619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761011620 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698761011621 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761011622 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 698761011623 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761011624 putative ligand binding site [chemical binding]; other site 698761011625 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761011626 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698761011627 Walker A/P-loop; other site 698761011628 ATP binding site [chemical binding]; other site 698761011629 Q-loop/lid; other site 698761011630 ABC transporter signature motif; other site 698761011631 Walker B; other site 698761011632 D-loop; other site 698761011633 H-loop/switch region; other site 698761011634 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761011635 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761011636 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761011637 TM-ABC transporter signature motif; other site 698761011638 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761011639 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761011640 TM-ABC transporter signature motif; other site 698761011641 succinic semialdehyde dehydrogenase; Region: PLN02278 698761011642 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698761011643 tetramerization interface [polypeptide binding]; other site 698761011644 NAD(P) binding site [chemical binding]; other site 698761011645 catalytic residues [active] 698761011646 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 698761011647 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 698761011648 catalytic Zn binding site [ion binding]; other site 698761011649 NAD binding site [chemical binding]; other site 698761011650 structural Zn binding site [ion binding]; other site 698761011651 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 698761011652 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761011653 putative ligand binding site [chemical binding]; other site 698761011654 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761011655 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761011656 Walker A/P-loop; other site 698761011657 ATP binding site [chemical binding]; other site 698761011658 Q-loop/lid; other site 698761011659 ABC transporter signature motif; other site 698761011660 Walker B; other site 698761011661 D-loop; other site 698761011662 H-loop/switch region; other site 698761011663 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761011664 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761011665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761011666 TM-ABC transporter signature motif; other site 698761011667 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761011668 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761011669 TM-ABC transporter signature motif; other site 698761011670 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 698761011671 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 698761011672 catalytic Zn binding site [ion binding]; other site 698761011673 NAD binding site [chemical binding]; other site 698761011674 structural Zn binding site [ion binding]; other site 698761011675 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698761011676 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698761011677 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761011678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761011679 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 698761011680 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698761011681 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761011682 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 698761011683 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761011684 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761011685 TM-ABC transporter signature motif; other site 698761011686 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761011687 TM-ABC transporter signature motif; other site 698761011688 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761011689 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761011690 Walker A/P-loop; other site 698761011691 ATP binding site [chemical binding]; other site 698761011692 Q-loop/lid; other site 698761011693 ABC transporter signature motif; other site 698761011694 Walker B; other site 698761011695 D-loop; other site 698761011696 H-loop/switch region; other site 698761011697 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761011698 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 698761011699 aminotransferase; Validated; Region: PRK09148 698761011700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761011701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761011702 homodimer interface [polypeptide binding]; other site 698761011703 catalytic residue [active] 698761011704 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 698761011705 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761011706 putative ligand binding site [chemical binding]; other site 698761011707 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 698761011708 active site 698761011709 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698761011710 dimer interface [polypeptide binding]; other site 698761011711 non-prolyl cis peptide bond; other site 698761011712 insertion regions; other site 698761011713 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698761011714 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 698761011715 short chain dehydrogenase; Provisional; Region: PRK06138 698761011716 classical (c) SDRs; Region: SDR_c; cd05233 698761011717 NAD(P) binding site [chemical binding]; other site 698761011718 active site 698761011719 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 698761011720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761011721 catalytic site [active] 698761011722 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761011723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761011724 DNA-binding site [nucleotide binding]; DNA binding site 698761011725 FCD domain; Region: FCD; pfam07729 698761011726 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698761011727 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 698761011728 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 698761011729 NAD binding site [chemical binding]; other site 698761011730 catalytic Zn binding site [ion binding]; other site 698761011731 substrate binding site [chemical binding]; other site 698761011732 structural Zn binding site [ion binding]; other site 698761011733 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698761011734 HAMP domain; Region: HAMP; pfam00672 698761011735 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761011736 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761011737 dimer interface [polypeptide binding]; other site 698761011738 putative CheW interface [polypeptide binding]; other site 698761011739 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698761011740 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 698761011741 PA14 domain; Region: PA14; cl08459 698761011742 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 698761011743 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 698761011744 Protein of unknown function (DUF968); Region: DUF968; pfam06147 698761011745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698761011746 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 698761011747 DctM-like transporters; Region: DctM; pfam06808 698761011748 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 698761011749 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 698761011750 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 698761011751 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761011752 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761011753 haloalkane dehalogenase; Provisional; Region: PRK03592 698761011754 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761011755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761011756 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698761011757 dimerization interface [polypeptide binding]; other site 698761011758 substrate binding pocket [chemical binding]; other site 698761011759 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761011760 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 698761011761 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698761011762 DAK2 domain; Region: Dak2; pfam02734 698761011763 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 698761011764 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 698761011765 active site 698761011766 metal binding site [ion binding]; metal-binding site 698761011767 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 698761011768 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 698761011769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761011770 S-adenosylmethionine binding site [chemical binding]; other site 698761011771 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 698761011772 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698761011773 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 698761011774 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698761011775 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698761011776 plasmid partitioning protein; Provisional; Region: PRK13832 698761011777 ParB-like nuclease domain; Region: ParB; smart00470 698761011778 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 698761011779 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 698761011780 Uncharacterized conserved protein [Function unknown]; Region: COG5489 698761011781 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 698761011782 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698761011783 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 698761011784 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698761011785 Walker A motif; other site 698761011786 ATP binding site [chemical binding]; other site 698761011787 Walker B motif; other site 698761011788 Conjugal transfer protein TraD; Region: TraD; cl05753 698761011789 conjugal transfer protein TraC; Provisional; Region: PRK13848 698761011790 Dtr system oriT relaxase; Provisional; Region: PRK13826 698761011791 MobA/MobL family; Region: MobA_MobL; pfam03389 698761011792 AAA domain; Region: AAA_30; pfam13604 698761011793 Family description; Region: UvrD_C_2; pfam13538 698761011794 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 698761011795 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 698761011796 conjugal transfer protein TraB; Provisional; Region: PRK13825 698761011797 active site 698761011798 catalytic triad [active] 698761011799 dimer interface [polypeptide binding]; other site 698761011800 conjugal transfer protein TraH; Provisional; Region: PRK13843 698761011801 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 698761011802 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761011803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761011804 non-specific DNA binding site [nucleotide binding]; other site 698761011805 salt bridge; other site 698761011806 sequence-specific DNA binding site [nucleotide binding]; other site 698761011807 Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228 698761011808 transcriptional regulator TraR; Provisional; Region: PRK13870 698761011809 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698761011810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761011811 DNA binding residues [nucleotide binding] 698761011812 dimerization interface [polypeptide binding]; other site 698761011813 conjugal transfer protein TrbI; Provisional; Region: PRK13831 698761011814 conjugal transfer protein TrbH; Provisional; Region: PRK13835 698761011815 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 698761011816 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 698761011817 VirB7 interaction site; other site 698761011818 conjugal transfer protein TrbF; Provisional; Region: PRK13836 698761011819 conjugal transfer protein TrbL; Provisional; Region: PRK13841 698761011820 entry exclusion protein TrbK, Ti-type; Region: TrbK_Ti; TIGR04361 698761011821 conjugal transfer protein TrbJ; Provisional; Region: PRK13842 698761011822 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 698761011823 conjugal transfer protein TrbE; Provisional; Region: PRK13830 698761011824 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 698761011825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761011826 Walker A/P-loop; other site 698761011827 ATP binding site [chemical binding]; other site 698761011828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761011829 Walker B; other site 698761011830 D-loop; other site 698761011831 H-loop/switch region; other site 698761011832 conjugal transfer protein TrbD; Provisional; Region: PRK13823 698761011833 conjugal transfer protein TrbC; Provisional; Region: PRK13871 698761011834 conjugal transfer protein TrbB; Provisional; Region: PRK13833 698761011835 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698761011836 ATP binding site [chemical binding]; other site 698761011837 Walker A motif; other site 698761011838 hexamer interface [polypeptide binding]; other site 698761011839 Walker B motif; other site 698761011840 Autoinducer synthetase; Region: Autoind_synth; cl17404 698761011841 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 698761011842 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698761011843 DNA binding residues [nucleotide binding] 698761011844 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698761011845 P-loop; other site 698761011846 Magnesium ion binding site [ion binding]; other site 698761011847 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698761011848 Magnesium ion binding site [ion binding]; other site 698761011849 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 698761011850 ParB-like nuclease domain; Region: ParBc; pfam02195 698761011851 replication initiation protein RepC; Provisional; Region: PRK13824 698761011852 Replication protein C N-terminal domain; Region: RP-C; pfam03428 698761011853 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 698761011854 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698761011855 DNA-binding site [nucleotide binding]; DNA binding site 698761011856 RNA-binding motif; other site 698761011857 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698761011858 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698761011859 catalytic residues [active] 698761011860 catalytic nucleophile [active] 698761011861 Presynaptic Site I dimer interface [polypeptide binding]; other site 698761011862 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698761011863 Synaptic Flat tetramer interface [polypeptide binding]; other site 698761011864 Synaptic Site I dimer interface [polypeptide binding]; other site 698761011865 DNA binding site [nucleotide binding] 698761011866 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 698761011867 HTH DNA binding domain; Region: HTH_13; pfam11972 698761011868 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761011869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761011870 non-specific DNA binding site [nucleotide binding]; other site 698761011871 salt bridge; other site 698761011872 sequence-specific DNA binding site [nucleotide binding]; other site 698761011873 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 698761011874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761011875 non-specific DNA binding site [nucleotide binding]; other site 698761011876 salt bridge; other site 698761011877 sequence-specific DNA binding site [nucleotide binding]; other site 698761011878 HipA N-terminal domain; Region: Couple_hipA; pfam13657 698761011879 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 698761011880 HipA-like N-terminal domain; Region: HipA_N; pfam07805 698761011881 HipA-like C-terminal domain; Region: HipA_C; pfam07804 698761011882 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698761011883 Family description; Region: UvrD_C_2; pfam13538 698761011884 AAA ATPase domain; Region: AAA_15; pfam13175 698761011885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761011886 Walker A/P-loop; other site 698761011887 ATP binding site [chemical binding]; other site 698761011888 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 698761011889 putative active site [active] 698761011890 putative metal-binding site [ion binding]; other site 698761011891 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 698761011892 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 698761011893 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 698761011894 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698761011895 active site 698761011896 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 698761011897 Protein of unknown function (DUF968); Region: DUF968; pfam06147 698761011898 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761011899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761011900 S-adenosylmethionine binding site [chemical binding]; other site 698761011901 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761011902 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 698761011903 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 698761011904 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 698761011905 active site 698761011906 dimer interface [polypeptide binding]; other site 698761011907 non-prolyl cis peptide bond; other site 698761011908 insertion regions; other site 698761011909 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761011910 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698761011911 Walker A/P-loop; other site 698761011912 ATP binding site [chemical binding]; other site 698761011913 Q-loop/lid; other site 698761011914 ABC transporter signature motif; other site 698761011915 Walker B; other site 698761011916 D-loop; other site 698761011917 H-loop/switch region; other site 698761011918 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698761011919 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698761011920 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698761011921 TM-ABC transporter signature motif; other site 698761011922 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 698761011923 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 698761011924 putative ligand binding site [chemical binding]; other site 698761011925 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698761011926 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698761011927 Walker A/P-loop; other site 698761011928 ATP binding site [chemical binding]; other site 698761011929 Q-loop/lid; other site 698761011930 ABC transporter signature motif; other site 698761011931 Walker B; other site 698761011932 D-loop; other site 698761011933 H-loop/switch region; other site 698761011934 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761011935 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 698761011936 Flavin binding site [chemical binding]; other site 698761011937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761011938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761011939 DNA binding residues [nucleotide binding] 698761011940 dimerization interface [polypeptide binding]; other site 698761011941 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761011942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698761011943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761011944 dimer interface [polypeptide binding]; other site 698761011945 conserved gate region; other site 698761011946 putative PBP binding loops; other site 698761011947 ABC-ATPase subunit interface; other site 698761011948 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761011949 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698761011950 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698761011951 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698761011952 active site 698761011953 non-prolyl cis peptide bond; other site 698761011954 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761011955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761011956 active site 698761011957 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761011958 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 698761011959 Flavin binding site [chemical binding]; other site 698761011960 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 698761011961 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 698761011962 active site 698761011963 dimer interface [polypeptide binding]; other site 698761011964 non-prolyl cis peptide bond; other site 698761011965 insertion regions; other site 698761011966 Homeodomain-like domain; Region: HTH_23; pfam13384 698761011967 Winged helix-turn helix; Region: HTH_29; pfam13551 698761011968 Homeodomain-like domain; Region: HTH_32; pfam13565 698761011969 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698761011970 MarR family; Region: MarR_2; pfam12802 698761011971 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761011972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761011973 Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186 698761011974 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761011975 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698761011976 IHF - DNA interface [nucleotide binding]; other site 698761011977 IHF dimer interface [polypeptide binding]; other site 698761011978 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761011979 MULE transposase domain; Region: MULE; pfam10551 698761011980 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 698761011981 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761011982 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 698761011983 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 698761011984 active site 698761011985 DNA binding site [nucleotide binding] 698761011986 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 698761011987 DNA binding site [nucleotide binding] 698761011988 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 698761011989 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 698761011990 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761011991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761011992 non-specific DNA binding site [nucleotide binding]; other site 698761011993 salt bridge; other site 698761011994 sequence-specific DNA binding site [nucleotide binding]; other site 698761011995 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 698761011996 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 698761011997 substrate binding pocket [chemical binding]; other site 698761011998 substrate-Mg2+ binding site; other site 698761011999 aspartate-rich region 1; other site 698761012000 aspartate-rich region 2; other site 698761012001 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 698761012002 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698761012003 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698761012004 substrate binding pocket [chemical binding]; other site 698761012005 chain length determination region; other site 698761012006 substrate-Mg2+ binding site; other site 698761012007 catalytic residues [active] 698761012008 aspartate-rich region 1; other site 698761012009 active site lid residues [active] 698761012010 aspartate-rich region 2; other site 698761012011 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698761012012 Cytochrome P450; Region: p450; cl12078 698761012013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761012014 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 698761012015 NAD(P) binding site [chemical binding]; other site 698761012016 active site 698761012017 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 698761012018 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 698761012019 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698761012020 Cytochrome P450; Region: p450; cl12078 698761012021 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698761012022 Cytochrome P450; Region: p450; cl12078 698761012023 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 698761012024 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 698761012025 active site 698761012026 TDP-binding site; other site 698761012027 acceptor substrate-binding pocket; other site 698761012028 homodimer interface [polypeptide binding]; other site 698761012029 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761012030 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698761012031 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761012032 Predicted membrane protein [Function unknown]; Region: COG2259 698761012033 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761012034 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761012035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761012036 Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186 698761012037 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761012038 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761012039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761012040 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 698761012041 putative substrate binding pocket [chemical binding]; other site 698761012042 putative dimerization interface [polypeptide binding]; other site 698761012043 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 698761012044 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698761012045 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698761012046 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 698761012047 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761012048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761012049 homodimer interface [polypeptide binding]; other site 698761012050 catalytic residue [active] 698761012051 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 698761012052 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698761012053 putative active site [active] 698761012054 putative NTP binding site [chemical binding]; other site 698761012055 putative nucleic acid binding site [nucleotide binding]; other site 698761012056 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698761012057 Winged helix-turn helix; Region: HTH_29; pfam13551 698761012058 Homeodomain-like domain; Region: HTH_23; cl17451 698761012059 Homeodomain-like domain; Region: HTH_32; pfam13565 698761012060 Winged helix-turn helix; Region: HTH_33; pfam13592 698761012061 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698761012062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698761012063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761012064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761012065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761012066 dimerization interface [polypeptide binding]; other site 698761012067 Nodulation protein A (NodA); Region: NodA; pfam02474 698761012068 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 698761012069 amphipathic channel; other site 698761012070 Asn-Pro-Ala signature motifs; other site 698761012071 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761012072 MULE transposase domain; Region: MULE; pfam10551 698761012073 Phasin protein; Region: Phasin_2; cl11491 698761012074 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761012075 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761012076 MarR family; Region: MarR_2; pfam12802 698761012077 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761012078 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761012079 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761012080 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761012081 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761012082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761012083 dimer interface [polypeptide binding]; other site 698761012084 conserved gate region; other site 698761012085 putative PBP binding loops; other site 698761012086 ABC-ATPase subunit interface; other site 698761012087 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761012088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761012089 dimer interface [polypeptide binding]; other site 698761012090 conserved gate region; other site 698761012091 putative PBP binding loops; other site 698761012092 ABC-ATPase subunit interface; other site 698761012093 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761012094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761012095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761012096 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761012097 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761012098 Walker A/P-loop; other site 698761012099 ATP binding site [chemical binding]; other site 698761012100 Q-loop/lid; other site 698761012101 ABC transporter signature motif; other site 698761012102 Walker B; other site 698761012103 D-loop; other site 698761012104 H-loop/switch region; other site 698761012105 TOBE domain; Region: TOBE; pfam03459 698761012106 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 698761012107 DNA binding residues [nucleotide binding] 698761012108 dimerization interface [polypeptide binding]; other site 698761012109 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 698761012110 AIR carboxylase; Region: AIRC; smart01001 698761012111 Protein of unknown function DUF111; Region: DUF111; cl03398 698761012112 Protein of unknown function DUF111; Region: DUF111; cl03398 698761012113 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698761012114 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698761012115 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698761012116 Transposase [DNA replication, recombination, and repair]; Region: COG5433 698761012117 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761012118 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761012119 Walker A/P-loop; other site 698761012120 ATP binding site [chemical binding]; other site 698761012121 Q-loop/lid; other site 698761012122 ABC transporter signature motif; other site 698761012123 Walker B; other site 698761012124 D-loop; other site 698761012125 H-loop/switch region; other site 698761012126 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 698761012127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761012128 substrate binding pocket [chemical binding]; other site 698761012129 membrane-bound complex binding site; other site 698761012130 hinge residues; other site 698761012131 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698761012132 homotrimer interaction site [polypeptide binding]; other site 698761012133 putative active site [active] 698761012134 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698761012135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761012136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761012137 homodimer interface [polypeptide binding]; other site 698761012138 catalytic residue [active] 698761012139 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 698761012140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761012141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761012142 dimerization interface [polypeptide binding]; other site 698761012143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 698761012144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761012145 putative substrate translocation pore; other site 698761012146 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 698761012147 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698761012148 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 698761012149 putative NAD(P) binding site [chemical binding]; other site 698761012150 putative substrate binding site [chemical binding]; other site 698761012151 catalytic Zn binding site [ion binding]; other site 698761012152 structural Zn binding site [ion binding]; other site 698761012153 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761012154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761012155 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698761012156 dimerization interface [polypeptide binding]; other site 698761012157 substrate binding pocket [chemical binding]; other site 698761012158 Predicted transcriptional regulators [Transcription]; Region: COG1733 698761012159 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698761012160 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698761012161 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761012162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761012163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761012164 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761012165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761012166 DNA-binding site [nucleotide binding]; DNA binding site 698761012167 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761012168 MULE transposase domain; Region: MULE; pfam10551 698761012169 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 698761012170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761012171 motif II; other site 698761012172 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 698761012173 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698761012174 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761012175 catalytic residue [active] 698761012176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761012177 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761012178 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698761012179 dimerization interface [polypeptide binding]; other site 698761012180 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698761012181 ATP binding site [chemical binding]; other site 698761012182 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 698761012183 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 698761012184 HupF/HypC family; Region: HupF_HypC; pfam01455 698761012185 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698761012186 Acylphosphatase; Region: Acylphosphatase; pfam00708 698761012187 HypF finger; Region: zf-HYPF; pfam07503 698761012188 HypF finger; Region: zf-HYPF; pfam07503 698761012189 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 698761012190 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698761012191 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 698761012192 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698761012193 coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295 698761012194 hydrogenase assembly chaperone HypC/HupF; Region: hypC_hupF; TIGR00074 698761012195 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698761012196 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 698761012197 putative substrate-binding site; other site 698761012198 nickel binding site [ion binding]; other site 698761012199 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698761012200 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 698761012201 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 698761012202 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698761012203 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 698761012204 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 698761012205 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698761012206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 698761012207 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 698761012208 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698761012209 Cytochrome P450; Region: p450; cl12078 698761012210 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 698761012211 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 698761012212 Transposase; Region: HTH_Tnp_1; pfam01527 698761012213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012214 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698761012215 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 698761012216 catalytic residues [active] 698761012217 catalytic nucleophile [active] 698761012218 Recombinase; Region: Recombinase; pfam07508 698761012219 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698761012220 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761012221 Winged helix-turn helix; Region: HTH_29; pfam13551 698761012222 Homeodomain-like domain; Region: HTH_32; pfam13565 698761012223 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698761012224 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 698761012225 catalytic residues [active] 698761012226 catalytic nucleophile [active] 698761012227 Recombinase; Region: Recombinase; pfam07508 698761012228 Helix-turn-helix domain; Region: HTH_17; pfam12728 698761012229 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698761012230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761012231 FeS/SAM binding site; other site 698761012232 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 698761012233 SnoaL-like domain; Region: SnoaL_3; pfam13474 698761012234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761012235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761012236 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 698761012237 putative substrate binding pocket [chemical binding]; other site 698761012238 putative dimerization interface [polypeptide binding]; other site 698761012239 Helix-turn-helix domain; Region: HTH_18; pfam12833 698761012240 Nodulation protein A (NodA); Region: NodA; pfam02474 698761012241 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761012242 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 698761012243 catalytic triad [active] 698761012244 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 698761012245 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698761012246 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698761012247 dimer interface [polypeptide binding]; other site 698761012248 active site 698761012249 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 698761012250 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 698761012251 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 698761012252 Sulfate transporter family; Region: Sulfate_transp; pfam00916 698761012253 STAS domain; Region: STAS_2; pfam13466 698761012254 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 698761012255 active site clefts [active] 698761012256 zinc binding site [ion binding]; other site 698761012257 dimer interface [polypeptide binding]; other site 698761012258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761012259 S-adenosylmethionine binding site [chemical binding]; other site 698761012260 coproporphyrinogen III oxidase; Validated; Region: PRK08208 698761012261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761012262 FeS/SAM binding site; other site 698761012263 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 698761012264 pseudoazurin; Region: pseudoazurin; TIGR02375 698761012265 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 698761012266 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 698761012267 Low-spin heme binding site [chemical binding]; other site 698761012268 Putative water exit pathway; other site 698761012269 Binuclear center (active site) [active] 698761012270 Putative proton exit pathway; other site 698761012271 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 698761012272 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 698761012273 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 698761012274 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 698761012275 Cytochrome c; Region: Cytochrom_C; pfam00034 698761012276 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698761012277 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 698761012278 4Fe-4S binding domain; Region: Fer4_5; pfam12801 698761012279 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 698761012280 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 698761012281 FixH; Region: FixH; pfam05751 698761012282 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698761012283 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698761012284 metal-binding site [ion binding] 698761012285 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698761012286 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698761012287 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 698761012288 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 698761012289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761012290 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698761012291 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698761012292 thiS-thiF/thiG interaction site; other site 698761012293 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761012294 MULE transposase domain; Region: MULE; pfam10551 698761012295 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 698761012296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761012297 FeS/SAM binding site; other site 698761012298 HemN C-terminal domain; Region: HemN_C; pfam06969 698761012299 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 698761012300 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 698761012301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761012302 putative active site [active] 698761012303 heme pocket [chemical binding]; other site 698761012304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761012305 dimer interface [polypeptide binding]; other site 698761012306 phosphorylation site [posttranslational modification] 698761012307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761012308 ATP binding site [chemical binding]; other site 698761012309 Mg2+ binding site [ion binding]; other site 698761012310 G-X-G motif; other site 698761012311 response regulator FixJ; Provisional; Region: fixJ; PRK09390 698761012312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761012313 active site 698761012314 phosphorylation site [posttranslational modification] 698761012315 intermolecular recognition site; other site 698761012316 dimerization interface [polypeptide binding]; other site 698761012317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761012318 DNA binding residues [nucleotide binding] 698761012319 dimerization interface [polypeptide binding]; other site 698761012320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698761012321 Integrase core domain; Region: rve; pfam00665 698761012322 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 698761012323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761012324 Walker A motif; other site 698761012325 ATP binding site [chemical binding]; other site 698761012326 Walker B motif; other site 698761012327 arginine finger; other site 698761012328 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 698761012329 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761012330 ligand binding site [chemical binding]; other site 698761012331 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 698761012332 putative switch regulator; other site 698761012333 non-specific DNA interactions [nucleotide binding]; other site 698761012334 DNA binding site [nucleotide binding] 698761012335 sequence specific DNA binding site [nucleotide binding]; other site 698761012336 putative cAMP binding site [chemical binding]; other site 698761012337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761012338 non-specific DNA binding site [nucleotide binding]; other site 698761012339 salt bridge; other site 698761012340 sequence-specific DNA binding site [nucleotide binding]; other site 698761012341 Replication protein C N-terminal domain; Region: RP-C; pfam03428 698761012342 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 698761012343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761012344 non-specific DNA binding site [nucleotide binding]; other site 698761012345 salt bridge; other site 698761012346 sequence-specific DNA binding site [nucleotide binding]; other site 698761012347 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761012348 MULE transposase domain; Region: MULE; pfam10551 698761012349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761012350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761012351 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 698761012352 putative substrate binding pocket [chemical binding]; other site 698761012353 putative dimerization interface [polypeptide binding]; other site 698761012354 Nodulation protein A (NodA); Region: NodA; pfam02474 698761012355 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698761012356 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698761012357 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 698761012358 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 698761012359 DXD motif; other site 698761012360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761012361 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761012362 S-adenosylmethionine binding site [chemical binding]; other site 698761012363 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 698761012364 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698761012365 ATP-binding ABC transporter family nodulation protein NodI; Region: nodI; TIGR01288 698761012366 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 698761012367 Walker A/P-loop; other site 698761012368 ATP binding site [chemical binding]; other site 698761012369 Q-loop/lid; other site 698761012370 ABC transporter signature motif; other site 698761012371 Walker B; other site 698761012372 D-loop; other site 698761012373 H-loop/switch region; other site 698761012374 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698761012375 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698761012376 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 698761012377 catalytic tetrad [active] 698761012378 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 698761012379 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 698761012380 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698761012381 Active Sites [active] 698761012382 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 698761012383 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 698761012384 CysD dimerization site [polypeptide binding]; other site 698761012385 G1 box; other site 698761012386 putative GEF interaction site [polypeptide binding]; other site 698761012387 GTP/Mg2+ binding site [chemical binding]; other site 698761012388 Switch I region; other site 698761012389 G2 box; other site 698761012390 G3 box; other site 698761012391 Switch II region; other site 698761012392 G4 box; other site 698761012393 G5 box; other site 698761012394 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698761012395 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698761012396 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 698761012397 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 698761012398 ligand-binding site [chemical binding]; other site 698761012399 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761012400 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698761012401 Transposase domain (DUF772); Region: DUF772; pfam05598 698761012402 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 698761012403 SIR2-like domain; Region: SIR2_2; pfam13289 698761012404 Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554 698761012405 NifZ domain; Region: NifZ; pfam04319 698761012406 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 698761012407 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 698761012408 Cell-cell adhesion domain; Region: Dicty_CAD; pfam05720 698761012409 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 698761012410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761012411 FeS/SAM binding site; other site 698761012412 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 698761012413 Nif-specific regulatory protein; Region: nifA; TIGR01817 698761012414 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 698761012415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761012416 Walker A motif; other site 698761012417 ATP binding site [chemical binding]; other site 698761012418 Walker B motif; other site 698761012419 arginine finger; other site 698761012420 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698761012421 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 698761012422 oxidoreductase; Provisional; Region: PRK10015 698761012423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761012424 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698761012425 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698761012426 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698761012427 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698761012428 Ligand binding site [chemical binding]; other site 698761012429 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698761012430 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 698761012431 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698761012432 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698761012433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761012434 catalytic residue [active] 698761012435 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 698761012436 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 698761012437 NifQ; Region: NifQ; pfam04891 698761012438 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 698761012439 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 698761012440 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 698761012441 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 698761012442 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 698761012443 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698761012444 catalytic triad [active] 698761012445 dimer interface [polypeptide binding]; other site 698761012446 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 698761012447 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 698761012448 tetramer interface [polypeptide binding]; other site 698761012449 active site 698761012450 Mg2+/Mn2+ binding site [ion binding]; other site 698761012451 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 698761012452 nucleotide binding site [chemical binding]; other site 698761012453 substrate binding site [chemical binding]; other site 698761012454 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 698761012455 short chain dehydrogenase; Validated; Region: PRK06484 698761012456 classical (c) SDRs; Region: SDR_c; cd05233 698761012457 NAD(P) binding site [chemical binding]; other site 698761012458 active site 698761012459 classical (c) SDRs; Region: SDR_c; cd05233 698761012460 NAD(P) binding site [chemical binding]; other site 698761012461 active site 698761012462 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698761012463 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698761012464 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 698761012465 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761012466 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761012467 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 698761012468 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761012469 DDE superfamily endonuclease; Region: DDE_5; cl17874 698761012470 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698761012471 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761012472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761012473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761012474 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 698761012475 putative substrate binding pocket [chemical binding]; other site 698761012476 putative dimerization interface [polypeptide binding]; other site 698761012477 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 698761012478 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 698761012479 Nucleotide-binding sites [chemical binding]; other site 698761012480 Walker A motif; other site 698761012481 Switch I region of nucleotide binding site; other site 698761012482 Fe4S4 binding sites [ion binding]; other site 698761012483 Switch II region of nucleotide binding site; other site 698761012484 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 698761012485 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 698761012486 MoFe protein alpha/beta subunit interactions; other site 698761012487 Alpha subunit P cluster binding residues; other site 698761012488 FeMoco binding residues [chemical binding]; other site 698761012489 MoFe protein alpha subunit/Fe protein contacts; other site 698761012490 MoFe protein dimer/ dimer interactions; other site 698761012491 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 698761012492 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 698761012493 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 698761012494 MoFe protein beta/alpha subunit interactions; other site 698761012495 Beta subunit P cluster binding residues; other site 698761012496 MoFe protein beta subunit/Fe protein contacts; other site 698761012497 MoFe protein dimer/ dimer interactions; other site 698761012498 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 698761012499 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 698761012500 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 698761012501 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 698761012502 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 698761012503 probable nitrogen fixation protein; Region: TIGR02935 698761012504 Rop-like; Region: Rop-like; pfam05082 698761012505 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 698761012506 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 698761012507 Exopolysaccharide production repressor; Region: SyrA; pfam11089 698761012508 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 698761012509 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 698761012510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761012511 catalytic residue [active] 698761012512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761012513 DNA binding site [nucleotide binding] 698761012514 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761012515 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761012516 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 698761012517 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761012518 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698761012519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761012520 DNA binding residues [nucleotide binding] 698761012521 dimerization interface [polypeptide binding]; other site 698761012522 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761012523 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 698761012524 inhibitor-cofactor binding pocket; inhibition site 698761012525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761012526 catalytic residue [active] 698761012527 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 698761012528 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 698761012529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012530 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698761012531 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 698761012532 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 698761012533 Int/Topo IB signature motif; other site 698761012534 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 698761012535 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 698761012536 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698761012537 active site 698761012538 DNA binding site [nucleotide binding] 698761012539 Int/Topo IB signature motif; other site 698761012540 Transposase; Region: HTH_Tnp_1; pfam01527 698761012541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012542 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698761012543 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698761012544 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698761012545 putative active site [active] 698761012546 transposase; Provisional; Region: PRK06526 698761012547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761012548 Walker A motif; other site 698761012549 ATP binding site [chemical binding]; other site 698761012550 Walker B motif; other site 698761012551 Cupin-like domain; Region: Cupin_8; pfam13621 698761012552 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761012553 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761012554 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 698761012555 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761012556 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698761012557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012559 Transposase; Region: HTH_Tnp_1; pfam01527 698761012560 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 698761012561 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 698761012562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012563 Transposase; Region: HTH_Tnp_1; pfam01527 698761012564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012565 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698761012566 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761012567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761012568 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761012569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761012570 FeS/SAM binding site; other site 698761012571 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 698761012572 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698761012573 nucleotide binding site [chemical binding]; other site 698761012574 homotetrameric interface [polypeptide binding]; other site 698761012575 putative phosphate binding site [ion binding]; other site 698761012576 putative allosteric binding site; other site 698761012577 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 698761012578 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 698761012579 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 698761012580 Predicted acyl esterases [General function prediction only]; Region: COG2936 698761012581 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 698761012582 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698761012583 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761012584 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698761012585 active site 698761012586 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698761012587 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698761012588 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761012589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761012590 Walker A/P-loop; other site 698761012591 ATP binding site [chemical binding]; other site 698761012592 Q-loop/lid; other site 698761012593 ABC transporter signature motif; other site 698761012594 Walker B; other site 698761012595 D-loop; other site 698761012596 H-loop/switch region; other site 698761012597 TOBE domain; Region: TOBE_2; pfam08402 698761012598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761012599 dimer interface [polypeptide binding]; other site 698761012600 conserved gate region; other site 698761012601 putative PBP binding loops; other site 698761012602 ABC-ATPase subunit interface; other site 698761012603 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761012604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761012605 dimer interface [polypeptide binding]; other site 698761012606 conserved gate region; other site 698761012607 putative PBP binding loops; other site 698761012608 ABC-ATPase subunit interface; other site 698761012609 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698761012610 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698761012611 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698761012612 putative active site [active] 698761012613 hypothetical protein; Provisional; Region: PRK07483 698761012614 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761012615 inhibitor-cofactor binding pocket; inhibition site 698761012616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761012617 catalytic residue [active] 698761012618 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698761012619 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 698761012620 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 698761012621 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761012622 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698761012623 active site 698761012624 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761012625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761012626 putative DNA binding site [nucleotide binding]; other site 698761012627 putative Zn2+ binding site [ion binding]; other site 698761012628 AsnC family; Region: AsnC_trans_reg; pfam01037 698761012629 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698761012630 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698761012631 metal binding site [ion binding]; metal-binding site 698761012632 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 698761012633 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698761012634 tetramer interface [polypeptide binding]; other site 698761012635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761012636 catalytic residue [active] 698761012637 ectoine utilization protein EutC; Validated; Region: PRK08291 698761012638 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698761012639 hypothetical protein; Provisional; Region: PRK07475 698761012640 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 698761012641 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761012642 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698761012643 active site 698761012644 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 698761012645 hypothetical protein; Provisional; Region: PRK07482 698761012646 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761012647 inhibitor-cofactor binding pocket; inhibition site 698761012648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761012649 catalytic residue [active] 698761012650 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761012651 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 698761012652 NAD(P) binding site [chemical binding]; other site 698761012653 catalytic residues [active] 698761012654 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 698761012655 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 698761012656 putative acyltransferase; Provisional; Region: PRK05790 698761012657 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698761012658 dimer interface [polypeptide binding]; other site 698761012659 active site 698761012660 hypothetical protein; Provisional; Region: PRK02853 698761012661 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 698761012662 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698761012663 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 698761012664 NAD(P) binding site [chemical binding]; other site 698761012665 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698761012666 MarR family; Region: MarR_2; cl17246 698761012667 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 698761012668 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698761012669 Cytochrome c; Region: Cytochrom_C; pfam00034 698761012670 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698761012671 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698761012672 putative active site [active] 698761012673 putative NTP binding site [chemical binding]; other site 698761012674 putative nucleic acid binding site [nucleotide binding]; other site 698761012675 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698761012676 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 698761012677 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 698761012678 Transposase; Region: HTH_Tnp_1; pfam01527 698761012679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012680 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 698761012681 Int/Topo IB signature motif; other site 698761012682 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 698761012683 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 698761012684 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698761012685 active site 698761012686 DNA binding site [nucleotide binding] 698761012687 Int/Topo IB signature motif; other site 698761012688 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 698761012689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012690 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 698761012691 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698761012692 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 698761012693 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 698761012694 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 698761012695 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 698761012696 Transposase [DNA replication, recombination, and repair]; Region: COG5433 698761012697 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698761012698 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698761012699 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698761012700 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698761012701 Ligand binding site [chemical binding]; other site 698761012702 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698761012703 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 698761012704 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698761012705 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698761012706 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 698761012707 CoA-transferase family III; Region: CoA_transf_3; pfam02515 698761012708 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 698761012709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761012710 FAD binding site [chemical binding]; other site 698761012711 substrate binding pocket [chemical binding]; other site 698761012712 catalytic base [active] 698761012713 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761012714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761012715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761012716 dimerization interface [polypeptide binding]; other site 698761012717 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 698761012718 active site 698761012719 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698761012720 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761012721 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698761012722 active site 698761012723 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 698761012724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012725 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 698761012726 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698761012727 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 698761012728 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698761012729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012731 Transposase; Region: HTH_Tnp_1; pfam01527 698761012732 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761012733 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761012734 Walker A/P-loop; other site 698761012735 ATP binding site [chemical binding]; other site 698761012736 Q-loop/lid; other site 698761012737 ABC transporter signature motif; other site 698761012738 Walker B; other site 698761012739 D-loop; other site 698761012740 H-loop/switch region; other site 698761012741 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761012742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761012743 dimer interface [polypeptide binding]; other site 698761012744 conserved gate region; other site 698761012745 putative PBP binding loops; other site 698761012746 ABC-ATPase subunit interface; other site 698761012747 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761012748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761012749 substrate binding pocket [chemical binding]; other site 698761012750 membrane-bound complex binding site; other site 698761012751 hinge residues; other site 698761012752 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698761012753 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 698761012754 dimer interface [polypeptide binding]; other site 698761012755 active site 698761012756 citrylCoA binding site [chemical binding]; other site 698761012757 NADH binding [chemical binding]; other site 698761012758 cationic pore residues; other site 698761012759 oxalacetate/citrate binding site [chemical binding]; other site 698761012760 coenzyme A binding site [chemical binding]; other site 698761012761 catalytic triad [active] 698761012762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012763 Transposase; Region: HTH_Tnp_1; cl17663 698761012764 putative transposase OrfB; Reviewed; Region: PHA02517 698761012765 HTH-like domain; Region: HTH_21; pfam13276 698761012766 Integrase core domain; Region: rve; pfam00665 698761012767 Integrase core domain; Region: rve_3; pfam13683 698761012768 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 698761012769 tetramer interface [polypeptide binding]; other site 698761012770 active site 698761012771 Mg2+/Mn2+ binding site [ion binding]; other site 698761012772 isocitrate lyase; Region: PLN02892 698761012773 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761012774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761012775 non-specific DNA binding site [nucleotide binding]; other site 698761012776 salt bridge; other site 698761012777 sequence-specific DNA binding site [nucleotide binding]; other site 698761012778 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698761012779 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698761012780 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698761012781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761012782 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 698761012783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761012784 FeS/SAM binding site; other site 698761012785 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 698761012786 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 698761012787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698761012788 FeS/SAM binding site; other site 698761012789 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 698761012790 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698761012791 Predicted periplasmic protein [Function unknown]; Region: COG3904 698761012792 Bacterial SH3 domain; Region: SH3_3; pfam08239 698761012793 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 698761012794 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698761012795 active site 698761012796 ATP binding site [chemical binding]; other site 698761012797 substrate binding site [chemical binding]; other site 698761012798 activation loop (A-loop); other site 698761012799 Protein phosphatase 2C; Region: PP2C_2; pfam13672 698761012800 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 698761012801 metal ion-dependent adhesion site (MIDAS); other site 698761012802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761012803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761012804 Coenzyme A binding pocket [chemical binding]; other site 698761012805 HemN C-terminal domain; Region: HemN_C; pfam06969 698761012806 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 698761012807 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698761012808 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 698761012809 putative active site [active] 698761012810 putative NTP binding site [chemical binding]; other site 698761012811 putative nucleic acid binding site [nucleotide binding]; other site 698761012812 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761012813 Winged helix-turn helix; Region: HTH_29; pfam13551 698761012814 Homeodomain-like domain; Region: HTH_32; pfam13565 698761012815 Integrase core domain; Region: rve; pfam00665 698761012816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761012817 non-specific DNA binding site [nucleotide binding]; other site 698761012818 salt bridge; other site 698761012819 sequence-specific DNA binding site [nucleotide binding]; other site 698761012820 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 698761012821 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698761012822 putative active site [active] 698761012823 putative NTP binding site [chemical binding]; other site 698761012824 putative nucleic acid binding site [nucleotide binding]; other site 698761012825 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698761012826 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698761012827 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 698761012828 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 698761012829 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698761012830 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 698761012831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761012832 Walker A motif; other site 698761012833 ATP binding site [chemical binding]; other site 698761012834 Walker B motif; other site 698761012835 arginine finger; other site 698761012836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761012837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698761012838 non-specific DNA binding site [nucleotide binding]; other site 698761012839 salt bridge; other site 698761012840 sequence-specific DNA binding site [nucleotide binding]; other site 698761012841 Integrase core domain; Region: rve; pfam00665 698761012842 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761012843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761012844 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761012845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012846 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698761012847 Transposase; Region: HTH_Tnp_1; pfam01527 698761012848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012849 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761012850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761012851 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761012852 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 698761012853 Protein of unknown function (DUF433); Region: DUF433; pfam04255 698761012854 HipA N-terminal domain; Region: Couple_hipA; pfam13657 698761012855 HipA-like N-terminal domain; Region: HipA_N; pfam07805 698761012856 HipA-like C-terminal domain; Region: HipA_C; pfam07804 698761012857 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761012858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761012859 non-specific DNA binding site [nucleotide binding]; other site 698761012860 salt bridge; other site 698761012861 sequence-specific DNA binding site [nucleotide binding]; other site 698761012862 Protein of unknown function (DUF433); Region: DUF433; pfam04255 698761012863 Transmembrane secretion effector; Region: MFS_3; pfam05977 698761012864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761012865 Transmembrane secretion effector; Region: MFS_3; pfam05977 698761012866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761012867 putative substrate translocation pore; other site 698761012868 putative transposase OrfB; Reviewed; Region: PHA02517 698761012869 HTH-like domain; Region: HTH_21; pfam13276 698761012870 Integrase core domain; Region: rve; pfam00665 698761012871 Integrase core domain; Region: rve_3; pfam13683 698761012872 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698761012873 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 698761012874 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 698761012875 Int/Topo IB signature motif; other site 698761012876 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698761012877 active site 698761012878 DNA binding site [nucleotide binding] 698761012879 Int/Topo IB signature motif; other site 698761012880 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 698761012881 Int/Topo IB signature motif; other site 698761012882 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 698761012883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761012884 Walker A motif; other site 698761012885 ATP binding site [chemical binding]; other site 698761012886 Walker B motif; other site 698761012887 Protein of unknown function (DUF812); Region: DUF812; pfam05667 698761012888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012889 Transposase; Region: HTH_Tnp_1; pfam01527 698761012890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012891 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698761012892 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761012893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761012894 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761012895 MarR family; Region: MarR_2; pfam12802 698761012896 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 698761012897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012898 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 698761012899 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698761012900 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 698761012901 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698761012902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761012903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761012904 Transposase; Region: HTH_Tnp_1; pfam01527 698761012905 drug efflux system protein MdtG; Provisional; Region: PRK09874 698761012906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761012907 putative substrate translocation pore; other site 698761012908 Bacterial SH3 domain; Region: SH3_3; cl17532 698761012909 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 698761012910 PemK-like protein; Region: PemK; pfam02452 698761012911 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698761012912 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698761012913 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761012914 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761012915 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761012916 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 698761012917 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698761012918 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698761012919 glutaminase active site [active] 698761012920 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698761012921 dimer interface [polypeptide binding]; other site 698761012922 active site 698761012923 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698761012924 dimer interface [polypeptide binding]; other site 698761012925 active site 698761012926 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698761012927 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 698761012928 putative dimer interface [polypeptide binding]; other site 698761012929 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 698761012930 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 698761012931 putative dimer interface [polypeptide binding]; other site 698761012932 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 698761012933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761012934 S-adenosylmethionine binding site [chemical binding]; other site 698761012935 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 698761012936 Toprim-like; Region: Toprim_2; pfam13155 698761012937 active site 698761012938 metal binding site [ion binding]; metal-binding site 698761012939 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 698761012940 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 698761012941 putative metal binding site [ion binding]; other site 698761012942 Uncharacterized conserved protein [Function unknown]; Region: COG1432 698761012943 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 698761012944 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 698761012945 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 698761012946 Uncharacterized conserved protein [Function unknown]; Region: COG5489 698761012947 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 698761012948 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 698761012949 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 698761012950 putative active site [active] 698761012951 putative NTP binding site [chemical binding]; other site 698761012952 putative nucleic acid binding site [nucleotide binding]; other site 698761012953 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 698761012954 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 698761012955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 698761012956 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 698761012957 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 698761012958 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 698761012959 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 698761012960 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698761012961 Walker A motif; other site 698761012962 ATP binding site [chemical binding]; other site 698761012963 Walker B motif; other site 698761012964 Conjugal transfer protein TraD; Region: TraD; cl05753 698761012965 conjugal transfer protein TraC; Provisional; Region: PRK13848 698761012966 Dtr system oriT relaxase; Provisional; Region: PRK13826 698761012967 MobA/MobL family; Region: MobA_MobL; pfam03389 698761012968 AAA domain; Region: AAA_30; pfam13604 698761012969 Family description; Region: UvrD_C_2; pfam13538 698761012970 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 698761012971 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 698761012972 conjugal transfer protein TraB; Provisional; Region: PRK13825 698761012973 active site 698761012974 catalytic triad [active] 698761012975 dimer interface [polypeptide binding]; other site 698761012976 conjugal transfer protein TraH; Provisional; Region: PRK13843 698761012977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761012978 non-specific DNA binding site [nucleotide binding]; other site 698761012979 salt bridge; other site 698761012980 sequence-specific DNA binding site [nucleotide binding]; other site 698761012981 Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228 698761012982 transcriptional regulator TraR; Provisional; Region: PRK13870 698761012983 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698761012984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761012985 DNA binding residues [nucleotide binding] 698761012986 dimerization interface [polypeptide binding]; other site 698761012987 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761012988 MULE transposase domain; Region: MULE; pfam10551 698761012989 conjugal transfer protein TrbI; Provisional; Region: PRK13831 698761012990 conjugal transfer protein TrbI; Provisional; Region: PRK13881 698761012991 conjugal transfer protein TrbH; Provisional; Region: PRK13835 698761012992 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 698761012993 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 698761012994 VirB7 interaction site; other site 698761012995 conjugal transfer protein TrbF; Provisional; Region: PRK13836 698761012996 conjugal transfer protein TrbL; Provisional; Region: PRK13841 698761012997 conjugal transfer protein TrbJ; Provisional; Region: PRK13842 698761012998 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 698761012999 conjugal transfer protein TrbE; Provisional; Region: PRK13830 698761013000 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 698761013001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761013002 Walker A/P-loop; other site 698761013003 ATP binding site [chemical binding]; other site 698761013004 conjugal transfer protein TrbD; Provisional; Region: PRK13823 698761013005 conjugal transfer protein TrbC; Provisional; Region: PRK13871 698761013006 conjugal transfer protein TrbB; Provisional; Region: PRK13833 698761013007 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698761013008 ATP binding site [chemical binding]; other site 698761013009 Walker A motif; other site 698761013010 hexamer interface [polypeptide binding]; other site 698761013011 Walker B motif; other site 698761013012 Autoinducer synthetase; Region: Autoind_synth; cl17404 698761013013 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 698761013014 MerR family regulatory protein; Region: MerR; pfam00376 698761013015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698761013016 P-loop; other site 698761013017 Magnesium ion binding site [ion binding]; other site 698761013018 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 698761013019 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 698761013020 ParB-like nuclease domain; Region: ParBc; pfam02195 698761013021 replication initiation protein RepC; Provisional; Region: PRK13824 698761013022 Replication protein C N-terminal domain; Region: RP-C; pfam03428 698761013023 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 698761013024 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698761013025 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698761013026 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698761013027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761013028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013029 active site 698761013030 phosphorylation site [posttranslational modification] 698761013031 intermolecular recognition site; other site 698761013032 dimerization interface [polypeptide binding]; other site 698761013033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761013034 DNA binding site [nucleotide binding] 698761013035 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 698761013036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761013037 ATP binding site [chemical binding]; other site 698761013038 Mg2+ binding site [ion binding]; other site 698761013039 G-X-G motif; other site 698761013040 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761013041 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761013042 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761013043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761013044 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761013045 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761013046 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 698761013047 mercuric reductase; Validated; Region: PRK06370 698761013048 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761013049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761013050 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698761013051 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698761013052 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 698761013053 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761013054 NAD binding site [chemical binding]; other site 698761013055 catalytic residues [active] 698761013056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761013057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013058 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698761013059 putative effector binding pocket; other site 698761013060 putative dimerization interface [polypeptide binding]; other site 698761013061 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761013062 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 698761013063 putative C-terminal domain interface [polypeptide binding]; other site 698761013064 putative GSH binding site (G-site) [chemical binding]; other site 698761013065 putative dimer interface [polypeptide binding]; other site 698761013066 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 698761013067 putative N-terminal domain interface [polypeptide binding]; other site 698761013068 putative dimer interface [polypeptide binding]; other site 698761013069 putative substrate binding pocket (H-site) [chemical binding]; other site 698761013070 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 698761013071 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 698761013072 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 698761013073 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 698761013074 FAD binding pocket [chemical binding]; other site 698761013075 FAD binding motif [chemical binding]; other site 698761013076 phosphate binding motif [ion binding]; other site 698761013077 beta-alpha-beta structure motif; other site 698761013078 NAD binding pocket [chemical binding]; other site 698761013079 Heme binding pocket [chemical binding]; other site 698761013080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761013081 catalytic loop [active] 698761013082 iron binding site [ion binding]; other site 698761013083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 698761013084 SnoaL-like domain; Region: SnoaL_2; pfam12680 698761013085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761013086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013087 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 698761013088 putative effector binding pocket; other site 698761013089 putative dimerization interface [polypeptide binding]; other site 698761013090 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761013091 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761013092 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 698761013093 putative active site [active] 698761013094 catalytic site [active] 698761013095 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 698761013096 ligand binding site [chemical binding]; other site 698761013097 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 698761013098 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698761013099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 698761013100 Predicted integral membrane protein [Function unknown]; Region: COG5473 698761013101 Cytochrome c2 [Energy production and conversion]; Region: COG3474 698761013102 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 698761013103 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698761013104 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698761013105 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 698761013106 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 698761013107 Subunit I/III interface [polypeptide binding]; other site 698761013108 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 698761013109 Subunit I/III interface [polypeptide binding]; other site 698761013110 Predicted small integral membrane protein [Function unknown]; Region: COG5605 698761013111 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 698761013112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761013113 DNA-binding site [nucleotide binding]; DNA binding site 698761013114 FCD domain; Region: FCD; pfam07729 698761013115 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761013116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698761013117 DNA-binding site [nucleotide binding]; DNA binding site 698761013118 FCD domain; Region: FCD; pfam07729 698761013119 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761013120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761013121 substrate binding pocket [chemical binding]; other site 698761013122 membrane-bound complex binding site; other site 698761013123 hinge residues; other site 698761013124 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761013125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013126 dimer interface [polypeptide binding]; other site 698761013127 conserved gate region; other site 698761013128 putative PBP binding loops; other site 698761013129 ABC-ATPase subunit interface; other site 698761013130 N-acetylneuraminate lyase; Provisional; Region: PRK04147 698761013131 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698761013132 inhibitor site; inhibition site 698761013133 active site 698761013134 dimer interface [polypeptide binding]; other site 698761013135 catalytic residue [active] 698761013136 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761013137 catalytic loop [active] 698761013138 iron binding site [ion binding]; other site 698761013139 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698761013140 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761013141 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761013142 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761013143 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761013144 Walker A/P-loop; other site 698761013145 ATP binding site [chemical binding]; other site 698761013146 Q-loop/lid; other site 698761013147 ABC transporter signature motif; other site 698761013148 Walker B; other site 698761013149 D-loop; other site 698761013150 H-loop/switch region; other site 698761013151 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 698761013152 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 698761013153 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698761013154 Amidase; Region: Amidase; pfam01425 698761013155 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 698761013156 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 698761013157 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761013158 Walker A/P-loop; other site 698761013159 ATP binding site [chemical binding]; other site 698761013160 Q-loop/lid; other site 698761013161 ABC transporter signature motif; other site 698761013162 Walker B; other site 698761013163 D-loop; other site 698761013164 H-loop/switch region; other site 698761013165 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761013166 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698761013167 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761013168 Walker A/P-loop; other site 698761013169 ATP binding site [chemical binding]; other site 698761013170 Q-loop/lid; other site 698761013171 ABC transporter signature motif; other site 698761013172 Walker B; other site 698761013173 D-loop; other site 698761013174 H-loop/switch region; other site 698761013175 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761013176 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698761013177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013178 dimer interface [polypeptide binding]; other site 698761013179 conserved gate region; other site 698761013180 putative PBP binding loops; other site 698761013181 ABC-ATPase subunit interface; other site 698761013182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761013183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013184 dimer interface [polypeptide binding]; other site 698761013185 conserved gate region; other site 698761013186 putative PBP binding loops; other site 698761013187 ABC-ATPase subunit interface; other site 698761013188 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761013189 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 698761013190 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 698761013191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761013192 DNA-binding site [nucleotide binding]; DNA binding site 698761013193 FCD domain; Region: FCD; pfam07729 698761013194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761013195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761013196 WHG domain; Region: WHG; pfam13305 698761013197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761013198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013199 putative substrate translocation pore; other site 698761013200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761013202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761013203 Cupin; Region: Cupin_6; pfam12852 698761013204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761013205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761013206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761013207 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761013208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013209 putative substrate translocation pore; other site 698761013210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698761013211 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698761013212 Integrase core domain; Region: rve; pfam00665 698761013213 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698761013214 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761013215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761013216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761013217 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698761013218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761013219 NAD(P) binding site [chemical binding]; other site 698761013220 active site 698761013221 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 698761013222 active site 698761013223 catalytic triad [active] 698761013224 oxyanion hole [active] 698761013225 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 698761013226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013227 active site 698761013228 phosphorylation site [posttranslational modification] 698761013229 intermolecular recognition site; other site 698761013230 dimerization interface [polypeptide binding]; other site 698761013231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761013232 DNA binding residues [nucleotide binding] 698761013233 dimerization interface [polypeptide binding]; other site 698761013234 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 698761013235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013236 active site 698761013237 phosphorylation site [posttranslational modification] 698761013238 intermolecular recognition site; other site 698761013239 dimerization interface [polypeptide binding]; other site 698761013240 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 698761013241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013242 active site 698761013243 phosphorylation site [posttranslational modification] 698761013244 intermolecular recognition site; other site 698761013245 dimerization interface [polypeptide binding]; other site 698761013246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761013247 DNA binding residues [nucleotide binding] 698761013248 dimerization interface [polypeptide binding]; other site 698761013249 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 698761013250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761013251 PAS fold; Region: PAS_3; pfam08447 698761013252 putative active site [active] 698761013253 heme pocket [chemical binding]; other site 698761013254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761013255 PAS fold; Region: PAS_3; pfam08447 698761013256 putative active site [active] 698761013257 heme pocket [chemical binding]; other site 698761013258 PAS domain; Region: PAS_9; pfam13426 698761013259 PAS fold; Region: PAS_3; pfam08447 698761013260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761013261 putative active site [active] 698761013262 heme pocket [chemical binding]; other site 698761013263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761013264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761013265 ATP binding site [chemical binding]; other site 698761013266 Mg2+ binding site [ion binding]; other site 698761013267 G-X-G motif; other site 698761013268 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761013269 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761013270 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761013271 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698761013272 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698761013273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761013274 NAD(P) binding site [chemical binding]; other site 698761013275 active site 698761013276 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698761013277 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698761013278 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698761013279 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 698761013280 GAF domain; Region: GAF; pfam01590 698761013281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761013282 dimer interface [polypeptide binding]; other site 698761013283 phosphorylation site [posttranslational modification] 698761013284 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761013285 cyclase homology domain; Region: CHD; cd07302 698761013286 nucleotidyl binding site; other site 698761013287 metal binding site [ion binding]; metal-binding site 698761013288 dimer interface [polypeptide binding]; other site 698761013289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761013290 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698761013291 ligand binding site [chemical binding]; other site 698761013292 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761013293 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761013294 Walker A/P-loop; other site 698761013295 ATP binding site [chemical binding]; other site 698761013296 Q-loop/lid; other site 698761013297 ABC transporter signature motif; other site 698761013298 Walker B; other site 698761013299 D-loop; other site 698761013300 H-loop/switch region; other site 698761013301 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761013302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761013303 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761013304 TM-ABC transporter signature motif; other site 698761013305 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698761013306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761013307 DNA binding residues [nucleotide binding] 698761013308 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698761013309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761013310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761013311 active site 698761013312 catalytic tetrad [active] 698761013313 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698761013314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761013315 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 698761013316 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 698761013317 putative active site; other site 698761013318 catalytic residue [active] 698761013319 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698761013320 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 698761013321 putative N- and C-terminal domain interface [polypeptide binding]; other site 698761013322 putative active site [active] 698761013323 MgATP binding site [chemical binding]; other site 698761013324 catalytic site [active] 698761013325 metal binding site [ion binding]; metal-binding site 698761013326 putative xylulose binding site [chemical binding]; other site 698761013327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013328 active site 698761013329 phosphorylation site [posttranslational modification] 698761013330 intermolecular recognition site; other site 698761013331 dimerization interface [polypeptide binding]; other site 698761013332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761013333 dimer interface [polypeptide binding]; other site 698761013334 phosphorylation site [posttranslational modification] 698761013335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761013336 ATP binding site [chemical binding]; other site 698761013337 Mg2+ binding site [ion binding]; other site 698761013338 G-X-G motif; other site 698761013339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761013340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013341 active site 698761013342 phosphorylation site [posttranslational modification] 698761013343 intermolecular recognition site; other site 698761013344 dimerization interface [polypeptide binding]; other site 698761013345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761013346 DNA binding site [nucleotide binding] 698761013347 PsbP; Region: PsbP; cl03356 698761013348 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761013349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761013350 Walker A/P-loop; other site 698761013351 ATP binding site [chemical binding]; other site 698761013352 Q-loop/lid; other site 698761013353 ABC transporter signature motif; other site 698761013354 Walker B; other site 698761013355 D-loop; other site 698761013356 H-loop/switch region; other site 698761013357 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761013358 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698761013359 Walker A/P-loop; other site 698761013360 ATP binding site [chemical binding]; other site 698761013361 Q-loop/lid; other site 698761013362 ABC transporter signature motif; other site 698761013363 Walker B; other site 698761013364 D-loop; other site 698761013365 H-loop/switch region; other site 698761013366 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698761013367 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 698761013368 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 698761013369 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 698761013370 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 698761013371 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 698761013372 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 698761013373 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 698761013374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761013375 dimerization interface [polypeptide binding]; other site 698761013376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761013377 dimer interface [polypeptide binding]; other site 698761013378 phosphorylation site [posttranslational modification] 698761013379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761013380 ATP binding site [chemical binding]; other site 698761013381 Mg2+ binding site [ion binding]; other site 698761013382 G-X-G motif; other site 698761013383 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761013384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013385 active site 698761013386 phosphorylation site [posttranslational modification] 698761013387 intermolecular recognition site; other site 698761013388 dimerization interface [polypeptide binding]; other site 698761013389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761013390 DNA binding site [nucleotide binding] 698761013391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761013392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013393 active site 698761013394 phosphorylation site [posttranslational modification] 698761013395 intermolecular recognition site; other site 698761013396 dimerization interface [polypeptide binding]; other site 698761013397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761013398 DNA binding site [nucleotide binding] 698761013399 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761013400 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761013401 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761013402 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 698761013403 Protein export membrane protein; Region: SecD_SecF; cl14618 698761013404 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 698761013405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 698761013406 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 698761013407 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 698761013408 Cupin domain; Region: Cupin_2; pfam07883 698761013409 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761013410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013411 putative substrate translocation pore; other site 698761013412 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 698761013413 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761013414 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 698761013415 dimer interface [polypeptide binding]; other site 698761013416 putative metal binding site [ion binding]; other site 698761013417 short chain dehydrogenase; Provisional; Region: PRK07041 698761013418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761013419 NAD(P) binding site [chemical binding]; other site 698761013420 active site 698761013421 transcriptional activator TtdR; Provisional; Region: PRK09801 698761013422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013423 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761013424 putative effector binding pocket; other site 698761013425 dimerization interface [polypeptide binding]; other site 698761013426 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698761013427 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 698761013428 homodimer interface [polypeptide binding]; other site 698761013429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761013430 catalytic residue [active] 698761013431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 698761013432 YheO-like PAS domain; Region: PAS_6; pfam08348 698761013433 HTH domain; Region: HTH_22; pfam13309 698761013434 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 698761013435 active site 698761013436 homodimer interface [polypeptide binding]; other site 698761013437 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 698761013438 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698761013439 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698761013440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761013441 substrate binding pocket [chemical binding]; other site 698761013442 membrane-bound complex binding site; other site 698761013443 hinge residues; other site 698761013444 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 698761013445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013446 conserved gate region; other site 698761013447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013448 putative PBP binding loops; other site 698761013449 dimer interface [polypeptide binding]; other site 698761013450 ABC-ATPase subunit interface; other site 698761013451 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761013452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013453 dimer interface [polypeptide binding]; other site 698761013454 conserved gate region; other site 698761013455 putative PBP binding loops; other site 698761013456 ABC-ATPase subunit interface; other site 698761013457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761013458 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761013459 putative transposase OrfB; Reviewed; Region: PHA02517 698761013460 HTH-like domain; Region: HTH_21; pfam13276 698761013461 Integrase core domain; Region: rve; pfam00665 698761013462 Integrase core domain; Region: rve_2; pfam13333 698761013463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698761013464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761013465 Coenzyme A binding pocket [chemical binding]; other site 698761013466 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698761013467 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698761013468 motif 1; other site 698761013469 dimer interface [polypeptide binding]; other site 698761013470 active site 698761013471 motif 2; other site 698761013472 motif 3; other site 698761013473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761013474 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698761013475 active site 698761013476 metal binding site [ion binding]; metal-binding site 698761013477 Protein of unknown function (DUF2026); Region: DUF2026; pfam09641 698761013478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761013479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761013480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013481 D-galactonate transporter; Region: 2A0114; TIGR00893 698761013482 putative substrate translocation pore; other site 698761013483 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 698761013484 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 698761013485 haemagglutination activity domain; Region: Haemagg_act; pfam05860 698761013486 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 698761013487 YtkA-like; Region: YtkA; pfam13115 698761013488 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 698761013489 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761013490 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 698761013491 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761013492 EamA-like transporter family; Region: EamA; pfam00892 698761013493 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 698761013494 putative active site [active] 698761013495 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 698761013496 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 698761013497 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 698761013498 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698761013499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761013500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761013501 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698761013502 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 698761013503 E3 interaction surface; other site 698761013504 lipoyl attachment site [posttranslational modification]; other site 698761013505 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761013506 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698761013507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013508 putative substrate translocation pore; other site 698761013509 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698761013510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761013511 NAD(P) binding site [chemical binding]; other site 698761013512 active site 698761013513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761013514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761013516 dimerization interface [polypeptide binding]; other site 698761013517 Epoxide hydrolase N terminus; Region: EHN; pfam06441 698761013518 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761013519 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 698761013520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761013521 TPR motif; other site 698761013522 binding surface 698761013523 TPR repeat; Region: TPR_11; pfam13414 698761013524 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 698761013525 putative active site [active] 698761013526 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 698761013527 short chain dehydrogenase; Validated; Region: PRK08264 698761013528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761013529 NAD(P) binding site [chemical binding]; other site 698761013530 active site 698761013531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761013532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761013534 dimerization interface [polypeptide binding]; other site 698761013535 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698761013536 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698761013537 NAD(P) binding site [chemical binding]; other site 698761013538 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698761013539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013540 short chain dehydrogenase; Provisional; Region: PRK06179 698761013541 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761013542 NADP binding site [chemical binding]; other site 698761013543 active site 698761013544 steroid binding site; other site 698761013545 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698761013546 CoenzymeA binding site [chemical binding]; other site 698761013547 subunit interaction site [polypeptide binding]; other site 698761013548 PHB binding site; other site 698761013549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761013550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761013551 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698761013552 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761013553 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761013554 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761013555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761013556 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 698761013557 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698761013558 dimer interface [polypeptide binding]; other site 698761013559 active site 698761013560 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698761013561 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698761013562 active site 698761013563 non-prolyl cis peptide bond; other site 698761013564 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 698761013565 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761013566 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761013567 Walker A/P-loop; other site 698761013568 ATP binding site [chemical binding]; other site 698761013569 Q-loop/lid; other site 698761013570 ABC transporter signature motif; other site 698761013571 Walker B; other site 698761013572 D-loop; other site 698761013573 H-loop/switch region; other site 698761013574 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761013575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013576 dimer interface [polypeptide binding]; other site 698761013577 conserved gate region; other site 698761013578 putative PBP binding loops; other site 698761013579 ABC-ATPase subunit interface; other site 698761013580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013581 dimer interface [polypeptide binding]; other site 698761013582 conserved gate region; other site 698761013583 putative PBP binding loops; other site 698761013584 ABC-ATPase subunit interface; other site 698761013585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761013586 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761013587 substrate binding pocket [chemical binding]; other site 698761013588 membrane-bound complex binding site; other site 698761013589 hinge residues; other site 698761013590 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 698761013591 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761013592 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761013593 Walker A/P-loop; other site 698761013594 ATP binding site [chemical binding]; other site 698761013595 Q-loop/lid; other site 698761013596 ABC transporter signature motif; other site 698761013597 Walker B; other site 698761013598 D-loop; other site 698761013599 H-loop/switch region; other site 698761013600 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761013601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013602 dimer interface [polypeptide binding]; other site 698761013603 conserved gate region; other site 698761013604 putative PBP binding loops; other site 698761013605 ABC-ATPase subunit interface; other site 698761013606 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761013607 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761013608 substrate binding pocket [chemical binding]; other site 698761013609 membrane-bound complex binding site; other site 698761013610 hinge residues; other site 698761013611 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761013612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761013613 DNA-binding site [nucleotide binding]; DNA binding site 698761013614 FCD domain; Region: FCD; pfam07729 698761013615 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 698761013616 Predicted transcriptional regulator [Transcription]; Region: COG3905 698761013617 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698761013618 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698761013619 active site 698761013620 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698761013621 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698761013622 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 698761013623 putative active site [active] 698761013624 putative metal binding site [ion binding]; other site 698761013625 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 698761013626 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 698761013627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761013628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013629 active site 698761013630 phosphorylation site [posttranslational modification] 698761013631 intermolecular recognition site; other site 698761013632 dimerization interface [polypeptide binding]; other site 698761013633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761013634 DNA binding site [nucleotide binding] 698761013635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761013636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761013637 ATP binding site [chemical binding]; other site 698761013638 Mg2+ binding site [ion binding]; other site 698761013639 G-X-G motif; other site 698761013640 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 698761013641 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761013642 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761013643 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761013644 Walker A/P-loop; other site 698761013645 ATP binding site [chemical binding]; other site 698761013646 Q-loop/lid; other site 698761013647 ABC transporter signature motif; other site 698761013648 Walker B; other site 698761013649 D-loop; other site 698761013650 H-loop/switch region; other site 698761013651 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761013652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013653 dimer interface [polypeptide binding]; other site 698761013654 conserved gate region; other site 698761013655 putative PBP binding loops; other site 698761013656 ABC-ATPase subunit interface; other site 698761013657 hypothetical protein; Provisional; Region: PRK07475 698761013658 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761013659 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761013660 substrate binding pocket [chemical binding]; other site 698761013661 membrane-bound complex binding site; other site 698761013662 hinge residues; other site 698761013663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761013664 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 698761013665 putative DNA binding site [nucleotide binding]; other site 698761013666 putative Zn2+ binding site [ion binding]; other site 698761013667 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761013668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761013670 dimerization interface [polypeptide binding]; other site 698761013671 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 698761013672 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698761013673 PYR/PP interface [polypeptide binding]; other site 698761013674 dimer interface [polypeptide binding]; other site 698761013675 TPP binding site [chemical binding]; other site 698761013676 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698761013677 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 698761013678 TPP-binding site [chemical binding]; other site 698761013679 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 698761013680 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698761013681 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 698761013682 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 698761013683 Moco binding site; other site 698761013684 metal coordination site [ion binding]; other site 698761013685 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698761013686 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 698761013687 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 698761013688 RNA polymerase sigma factor; Provisional; Region: PRK12539 698761013689 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761013690 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 698761013691 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 698761013692 ParB-like nuclease domain; Region: ParBc; pfam02195 698761013693 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 698761013694 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 698761013695 dimer interface [polypeptide binding]; other site 698761013696 active site 698761013697 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698761013698 catalytic residues [active] 698761013699 substrate binding site [chemical binding]; other site 698761013700 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698761013701 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698761013702 dimer interface [polypeptide binding]; other site 698761013703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761013704 catalytic residue [active] 698761013705 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698761013706 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 698761013707 IucA / IucC family; Region: IucA_IucC; pfam04183 698761013708 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698761013709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013710 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761013711 putative substrate translocation pore; other site 698761013712 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698761013713 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698761013714 putative ligand binding residues [chemical binding]; other site 698761013715 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698761013716 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698761013717 ABC-ATPase subunit interface; other site 698761013718 dimer interface [polypeptide binding]; other site 698761013719 putative PBP binding regions; other site 698761013720 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698761013721 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698761013722 Walker A/P-loop; other site 698761013723 ATP binding site [chemical binding]; other site 698761013724 Q-loop/lid; other site 698761013725 ABC transporter signature motif; other site 698761013726 Walker B; other site 698761013727 D-loop; other site 698761013728 H-loop/switch region; other site 698761013729 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 698761013730 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698761013731 N-terminal plug; other site 698761013732 ligand-binding site [chemical binding]; other site 698761013733 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698761013734 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698761013735 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698761013736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761013737 NAD(P) binding site [chemical binding]; other site 698761013738 active site 698761013739 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761013740 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698761013741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761013742 dimerization interface [polypeptide binding]; other site 698761013743 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761013744 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761013745 dimer interface [polypeptide binding]; other site 698761013746 putative CheW interface [polypeptide binding]; other site 698761013747 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 698761013748 putative CheA interaction surface; other site 698761013749 hypothetical protein; Provisional; Region: PRK07036 698761013750 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761013751 inhibitor-cofactor binding pocket; inhibition site 698761013752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761013753 catalytic residue [active] 698761013754 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698761013755 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698761013756 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761013757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761013758 Walker A/P-loop; other site 698761013759 ATP binding site [chemical binding]; other site 698761013760 Q-loop/lid; other site 698761013761 ABC transporter signature motif; other site 698761013762 Walker B; other site 698761013763 D-loop; other site 698761013764 H-loop/switch region; other site 698761013765 TOBE domain; Region: TOBE_2; pfam08402 698761013766 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761013767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013768 putative PBP binding loops; other site 698761013769 dimer interface [polypeptide binding]; other site 698761013770 ABC-ATPase subunit interface; other site 698761013771 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761013772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013773 dimer interface [polypeptide binding]; other site 698761013774 conserved gate region; other site 698761013775 putative PBP binding loops; other site 698761013776 ABC-ATPase subunit interface; other site 698761013777 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 698761013778 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 698761013779 active site 698761013780 Zn binding site [ion binding]; other site 698761013781 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 698761013782 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761013783 NAD binding site [chemical binding]; other site 698761013784 catalytic residues [active] 698761013785 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761013786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761013787 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698761013788 Amidase; Region: Amidase; cl11426 698761013789 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 698761013790 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 698761013791 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761013792 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761013793 Walker A/P-loop; other site 698761013794 ATP binding site [chemical binding]; other site 698761013795 Q-loop/lid; other site 698761013796 ABC transporter signature motif; other site 698761013797 Walker B; other site 698761013798 D-loop; other site 698761013799 H-loop/switch region; other site 698761013800 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761013801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013802 dimer interface [polypeptide binding]; other site 698761013803 conserved gate region; other site 698761013804 putative PBP binding loops; other site 698761013805 ABC-ATPase subunit interface; other site 698761013806 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761013807 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761013808 substrate binding pocket [chemical binding]; other site 698761013809 membrane-bound complex binding site; other site 698761013810 hinge residues; other site 698761013811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761013812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698761013814 dimerization interface [polypeptide binding]; other site 698761013815 choline dehydrogenase; Validated; Region: PRK02106 698761013816 lycopene cyclase; Region: lycopene_cycl; TIGR01789 698761013817 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698761013818 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 698761013819 CoA-transferase family III; Region: CoA_transf_3; pfam02515 698761013820 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 698761013821 CoA-transferase family III; Region: CoA_transf_3; pfam02515 698761013822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761013823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013824 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 698761013825 putative dimerization interface [polypeptide binding]; other site 698761013826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 698761013827 NMT1-like family; Region: NMT1_2; pfam13379 698761013828 NMT1/THI5 like; Region: NMT1; pfam09084 698761013829 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761013830 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761013831 Walker A/P-loop; other site 698761013832 ATP binding site [chemical binding]; other site 698761013833 Q-loop/lid; other site 698761013834 ABC transporter signature motif; other site 698761013835 Walker B; other site 698761013836 D-loop; other site 698761013837 H-loop/switch region; other site 698761013838 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761013839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013840 dimer interface [polypeptide binding]; other site 698761013841 conserved gate region; other site 698761013842 putative PBP binding loops; other site 698761013843 ABC-ATPase subunit interface; other site 698761013844 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761013845 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761013846 TM-ABC transporter signature motif; other site 698761013847 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761013848 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761013849 TM-ABC transporter signature motif; other site 698761013850 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698761013851 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761013852 Walker A/P-loop; other site 698761013853 ATP binding site [chemical binding]; other site 698761013854 Q-loop/lid; other site 698761013855 ABC transporter signature motif; other site 698761013856 Walker B; other site 698761013857 D-loop; other site 698761013858 H-loop/switch region; other site 698761013859 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761013860 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698761013861 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 698761013862 putative ligand binding site [chemical binding]; other site 698761013863 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 698761013864 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 698761013865 active site 698761013866 putative substrate binding pocket [chemical binding]; other site 698761013867 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761013868 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 698761013869 putative C-terminal domain interface [polypeptide binding]; other site 698761013870 putative GSH binding site (G-site) [chemical binding]; other site 698761013871 putative dimer interface [polypeptide binding]; other site 698761013872 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 698761013873 N-terminal domain interface [polypeptide binding]; other site 698761013874 dimer interface [polypeptide binding]; other site 698761013875 substrate binding pocket (H-site) [chemical binding]; other site 698761013876 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 698761013877 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698761013878 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698761013879 hydrophobic ligand binding site; other site 698761013880 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 698761013881 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 698761013882 iron-sulfur cluster [ion binding]; other site 698761013883 [2Fe-2S] cluster binding site [ion binding]; other site 698761013884 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761013885 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698761013886 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761013887 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761013888 Walker A/P-loop; other site 698761013889 ATP binding site [chemical binding]; other site 698761013890 Q-loop/lid; other site 698761013891 ABC transporter signature motif; other site 698761013892 Walker B; other site 698761013893 D-loop; other site 698761013894 H-loop/switch region; other site 698761013895 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761013896 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761013897 Walker A/P-loop; other site 698761013898 ATP binding site [chemical binding]; other site 698761013899 Q-loop/lid; other site 698761013900 ABC transporter signature motif; other site 698761013901 Walker B; other site 698761013902 D-loop; other site 698761013903 H-loop/switch region; other site 698761013904 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761013905 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698761013906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013907 dimer interface [polypeptide binding]; other site 698761013908 conserved gate region; other site 698761013909 putative PBP binding loops; other site 698761013910 ABC-ATPase subunit interface; other site 698761013911 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761013912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761013913 dimer interface [polypeptide binding]; other site 698761013914 conserved gate region; other site 698761013915 putative PBP binding loops; other site 698761013916 ABC-ATPase subunit interface; other site 698761013917 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 698761013918 Autoinducer binding domain; Region: Autoind_bind; pfam03472 698761013919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761013920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761013921 DNA binding residues [nucleotide binding] 698761013922 dimerization interface [polypeptide binding]; other site 698761013923 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 698761013924 cytosine deaminase; Provisional; Region: PRK05985 698761013925 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 698761013926 active site 698761013927 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 698761013928 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 698761013929 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 698761013930 Protein export membrane protein; Region: SecD_SecF; cl14618 698761013931 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761013932 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761013933 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761013934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761013935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761013936 active site 698761013937 phosphorylation site [posttranslational modification] 698761013938 intermolecular recognition site; other site 698761013939 dimerization interface [polypeptide binding]; other site 698761013940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761013941 DNA binding site [nucleotide binding] 698761013942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761013943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761013944 dimerization interface [polypeptide binding]; other site 698761013945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761013946 dimer interface [polypeptide binding]; other site 698761013947 phosphorylation site [posttranslational modification] 698761013948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761013949 ATP binding site [chemical binding]; other site 698761013950 Mg2+ binding site [ion binding]; other site 698761013951 G-X-G motif; other site 698761013952 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698761013953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761013954 NAD(P) binding site [chemical binding]; other site 698761013955 active site 698761013956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761013957 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761013958 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761013959 Transmembrane secretion effector; Region: MFS_3; pfam05977 698761013960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761013961 putative substrate translocation pore; other site 698761013962 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 698761013963 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 698761013964 MOFRL family; Region: MOFRL; pfam05161 698761013965 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761013966 tartronate semialdehyde reductase; Provisional; Region: PRK15059 698761013967 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 698761013968 glyoxylate carboligase; Provisional; Region: PRK11269 698761013969 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698761013970 PYR/PP interface [polypeptide binding]; other site 698761013971 dimer interface [polypeptide binding]; other site 698761013972 TPP binding site [chemical binding]; other site 698761013973 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698761013974 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 698761013975 TPP-binding site [chemical binding]; other site 698761013976 transcriptional repressor IclR; Provisional; Region: PRK11569 698761013977 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 698761013978 Bacterial transcriptional regulator; Region: IclR; pfam01614 698761013979 guanine deaminase; Provisional; Region: PRK09228 698761013980 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 698761013981 active site 698761013982 Predicted membrane protein [Function unknown]; Region: COG3748 698761013983 Protein of unknown function (DUF989); Region: DUF989; pfam06181 698761013984 Cytochrome c; Region: Cytochrom_C; pfam00034 698761013985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761013986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761013987 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761013988 putative effector binding pocket; other site 698761013989 dimerization interface [polypeptide binding]; other site 698761013990 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 698761013991 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 698761013992 XdhC Rossmann domain; Region: XdhC_C; pfam13478 698761013993 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 698761013994 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698761013995 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761013996 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 698761013997 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761013998 catalytic loop [active] 698761013999 iron binding site [ion binding]; other site 698761014000 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698761014001 FAD binding domain; Region: FAD_binding_4; pfam01565 698761014002 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 698761014003 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 698761014004 active site 698761014005 homotetramer interface [polypeptide binding]; other site 698761014006 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 698761014007 ureidoglycolate hydrolase; Provisional; Region: PRK03606 698761014008 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698761014009 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 698761014010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761014011 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698761014012 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761014013 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761014014 Walker A/P-loop; other site 698761014015 ATP binding site [chemical binding]; other site 698761014016 Q-loop/lid; other site 698761014017 ABC transporter signature motif; other site 698761014018 Walker B; other site 698761014019 D-loop; other site 698761014020 H-loop/switch region; other site 698761014021 TOBE domain; Region: TOBE_2; pfam08402 698761014022 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761014023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014024 dimer interface [polypeptide binding]; other site 698761014025 conserved gate region; other site 698761014026 putative PBP binding loops; other site 698761014027 ABC-ATPase subunit interface; other site 698761014028 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761014029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014030 dimer interface [polypeptide binding]; other site 698761014031 conserved gate region; other site 698761014032 putative PBP binding loops; other site 698761014033 ABC-ATPase subunit interface; other site 698761014034 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761014035 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761014036 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761014037 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761014038 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761014039 DNA binding site [nucleotide binding] 698761014040 domain linker motif; other site 698761014041 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698761014042 ligand binding site [chemical binding]; other site 698761014043 dimerization interface [polypeptide binding]; other site 698761014044 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 698761014045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761014046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761014047 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698761014048 dimerization interface [polypeptide binding]; other site 698761014049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761014050 active site 698761014051 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761014052 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698761014053 Walker A/P-loop; other site 698761014054 ATP binding site [chemical binding]; other site 698761014055 Q-loop/lid; other site 698761014056 ABC transporter signature motif; other site 698761014057 Walker B; other site 698761014058 D-loop; other site 698761014059 H-loop/switch region; other site 698761014060 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698761014061 Walker A/P-loop; other site 698761014062 ATP binding site [chemical binding]; other site 698761014063 Q-loop/lid; other site 698761014064 ABC transporter signature motif; other site 698761014065 Walker B; other site 698761014066 D-loop; other site 698761014067 H-loop/switch region; other site 698761014068 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698761014069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698761014070 active site 698761014071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 698761014072 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 698761014073 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 698761014074 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 698761014075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761014076 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761014077 putative substrate translocation pore; other site 698761014078 Uncharacterized conserved protein [Function unknown]; Region: COG1739 698761014079 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698761014080 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 698761014081 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 698761014082 protein binding site [polypeptide binding]; other site 698761014083 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 698761014084 Catalytic dyad [active] 698761014085 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 698761014086 Porin subfamily; Region: Porin_2; pfam02530 698761014087 xanthine permease; Region: pbuX; TIGR03173 698761014088 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 698761014089 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698761014090 PYR/PP interface [polypeptide binding]; other site 698761014091 dimer interface [polypeptide binding]; other site 698761014092 TPP binding site [chemical binding]; other site 698761014093 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698761014094 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 698761014095 TPP-binding site [chemical binding]; other site 698761014096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761014097 putative substrate translocation pore; other site 698761014098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761014099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761014100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761014101 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698761014102 NMT1-like family; Region: NMT1_2; pfam13379 698761014103 substrate binding pocket [chemical binding]; other site 698761014104 membrane-bound complex binding site; other site 698761014105 hinge residues; other site 698761014106 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761014107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014108 dimer interface [polypeptide binding]; other site 698761014109 conserved gate region; other site 698761014110 putative PBP binding loops; other site 698761014111 ABC-ATPase subunit interface; other site 698761014112 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761014113 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761014114 Walker A/P-loop; other site 698761014115 ATP binding site [chemical binding]; other site 698761014116 Q-loop/lid; other site 698761014117 ABC transporter signature motif; other site 698761014118 Walker B; other site 698761014119 D-loop; other site 698761014120 H-loop/switch region; other site 698761014121 intracellular protease, PfpI family; Region: PfpI; TIGR01382 698761014122 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 698761014123 proposed catalytic triad [active] 698761014124 conserved cys residue [active] 698761014125 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 698761014126 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 698761014127 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698761014128 Sodium Bile acid symporter family; Region: SBF; pfam01758 698761014129 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698761014130 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 698761014131 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698761014132 acyl-activating enzyme (AAE) consensus motif; other site 698761014133 AMP binding site [chemical binding]; other site 698761014134 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698761014135 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698761014136 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698761014137 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698761014138 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698761014139 putative trimer interface [polypeptide binding]; other site 698761014140 putative CoA binding site [chemical binding]; other site 698761014141 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 698761014142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761014143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761014144 active site 698761014145 phosphorylation site [posttranslational modification] 698761014146 intermolecular recognition site; other site 698761014147 dimerization interface [polypeptide binding]; other site 698761014148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761014149 DNA binding site [nucleotide binding] 698761014150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761014151 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 698761014152 dimer interface [polypeptide binding]; other site 698761014153 phosphorylation site [posttranslational modification] 698761014154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761014155 ATP binding site [chemical binding]; other site 698761014156 Mg2+ binding site [ion binding]; other site 698761014157 G-X-G motif; other site 698761014158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698761014159 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 698761014160 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 698761014161 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 698761014162 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 698761014163 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 698761014164 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761014165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014166 dimer interface [polypeptide binding]; other site 698761014167 conserved gate region; other site 698761014168 putative PBP binding loops; other site 698761014169 ABC-ATPase subunit interface; other site 698761014170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014171 dimer interface [polypeptide binding]; other site 698761014172 conserved gate region; other site 698761014173 putative PBP binding loops; other site 698761014174 ABC-ATPase subunit interface; other site 698761014175 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698761014176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761014177 substrate binding pocket [chemical binding]; other site 698761014178 membrane-bound complex binding site; other site 698761014179 hinge residues; other site 698761014180 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 698761014181 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761014182 Walker A/P-loop; other site 698761014183 ATP binding site [chemical binding]; other site 698761014184 Q-loop/lid; other site 698761014185 ABC transporter signature motif; other site 698761014186 Walker B; other site 698761014187 D-loop; other site 698761014188 H-loop/switch region; other site 698761014189 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761014190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761014191 putative DNA binding site [nucleotide binding]; other site 698761014192 putative Zn2+ binding site [ion binding]; other site 698761014193 AsnC family; Region: AsnC_trans_reg; pfam01037 698761014194 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 698761014195 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 698761014196 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 698761014197 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 698761014198 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761014199 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761014200 Walker A/P-loop; other site 698761014201 ATP binding site [chemical binding]; other site 698761014202 Q-loop/lid; other site 698761014203 ABC transporter signature motif; other site 698761014204 Walker B; other site 698761014205 D-loop; other site 698761014206 H-loop/switch region; other site 698761014207 TOBE domain; Region: TOBE_2; pfam08402 698761014208 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761014209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014210 dimer interface [polypeptide binding]; other site 698761014211 conserved gate region; other site 698761014212 putative PBP binding loops; other site 698761014213 ABC-ATPase subunit interface; other site 698761014214 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698761014215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014216 putative PBP binding loops; other site 698761014217 dimer interface [polypeptide binding]; other site 698761014218 ABC-ATPase subunit interface; other site 698761014219 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761014220 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761014221 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761014222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761014223 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698761014224 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698761014225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761014226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761014227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761014228 dimerization interface [polypeptide binding]; other site 698761014229 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 698761014230 HPP family; Region: HPP; pfam04982 698761014231 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 698761014232 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698761014233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761014234 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761014235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761014236 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 698761014237 trimer interface [polypeptide binding]; other site 698761014238 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 698761014239 trimer interface [polypeptide binding]; other site 698761014240 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 698761014241 trimer interface [polypeptide binding]; other site 698761014242 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 698761014243 trimer interface [polypeptide binding]; other site 698761014244 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 698761014245 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 698761014246 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 698761014247 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 698761014248 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 698761014249 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761014250 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761014251 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761014252 nucleotide binding site [chemical binding]; other site 698761014253 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761014254 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698761014255 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698761014256 substrate binding site [chemical binding]; other site 698761014257 hexamer interface [polypeptide binding]; other site 698761014258 metal binding site [ion binding]; metal-binding site 698761014259 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761014260 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761014261 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761014262 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761014263 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698761014264 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761014265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014266 dimer interface [polypeptide binding]; other site 698761014267 conserved gate region; other site 698761014268 putative PBP binding loops; other site 698761014269 ABC-ATPase subunit interface; other site 698761014270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014271 dimer interface [polypeptide binding]; other site 698761014272 conserved gate region; other site 698761014273 putative PBP binding loops; other site 698761014274 ABC-ATPase subunit interface; other site 698761014275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761014276 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761014277 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761014278 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761014279 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698761014280 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761014281 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761014282 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761014283 DNA binding site [nucleotide binding] 698761014284 domain linker motif; other site 698761014285 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698761014286 dimerization interface [polypeptide binding]; other site 698761014287 ligand binding site [chemical binding]; other site 698761014288 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698761014289 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761014290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761014291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761014292 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761014293 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761014294 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761014295 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761014296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761014297 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761014298 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698761014299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 698761014300 Protein of unknown function (DUF805); Region: DUF805; pfam05656 698761014301 MoxR-like ATPases [General function prediction only]; Region: COG0714 698761014302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761014303 Walker A motif; other site 698761014304 ATP binding site [chemical binding]; other site 698761014305 Walker B motif; other site 698761014306 arginine finger; other site 698761014307 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 698761014308 Protein of unknown function DUF58; Region: DUF58; pfam01882 698761014309 Integral membrane protein DUF95; Region: DUF95; pfam01944 698761014310 RDD family; Region: RDD; pfam06271 698761014311 FOG: CBS domain [General function prediction only]; Region: COG0517 698761014312 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 698761014313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 698761014314 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698761014315 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 698761014316 Prostaglandin dehydrogenases; Region: PGDH; cd05288 698761014317 NAD(P) binding site [chemical binding]; other site 698761014318 substrate binding site [chemical binding]; other site 698761014319 dimer interface [polypeptide binding]; other site 698761014320 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 698761014321 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761014322 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 698761014323 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761014324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014325 dimer interface [polypeptide binding]; other site 698761014326 conserved gate region; other site 698761014327 putative PBP binding loops; other site 698761014328 ABC-ATPase subunit interface; other site 698761014329 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761014330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014331 putative PBP binding loops; other site 698761014332 dimer interface [polypeptide binding]; other site 698761014333 ABC-ATPase subunit interface; other site 698761014334 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761014335 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761014336 Walker A/P-loop; other site 698761014337 ATP binding site [chemical binding]; other site 698761014338 Q-loop/lid; other site 698761014339 ABC transporter signature motif; other site 698761014340 Walker B; other site 698761014341 D-loop; other site 698761014342 H-loop/switch region; other site 698761014343 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761014344 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761014345 Walker A/P-loop; other site 698761014346 ATP binding site [chemical binding]; other site 698761014347 Q-loop/lid; other site 698761014348 ABC transporter signature motif; other site 698761014349 Walker B; other site 698761014350 D-loop; other site 698761014351 H-loop/switch region; other site 698761014352 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761014353 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 698761014354 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698761014355 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 698761014356 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 698761014357 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 698761014358 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 698761014359 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761014360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761014361 Walker A/P-loop; other site 698761014362 ATP binding site [chemical binding]; other site 698761014363 Q-loop/lid; other site 698761014364 ABC transporter signature motif; other site 698761014365 Walker B; other site 698761014366 D-loop; other site 698761014367 H-loop/switch region; other site 698761014368 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761014369 Walker A/P-loop; other site 698761014370 ATP binding site [chemical binding]; other site 698761014371 Q-loop/lid; other site 698761014372 ABC transporter signature motif; other site 698761014373 Walker B; other site 698761014374 D-loop; other site 698761014375 H-loop/switch region; other site 698761014376 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761014377 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761014378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014379 dimer interface [polypeptide binding]; other site 698761014380 conserved gate region; other site 698761014381 putative PBP binding loops; other site 698761014382 ABC-ATPase subunit interface; other site 698761014383 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761014384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698761014385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014386 dimer interface [polypeptide binding]; other site 698761014387 conserved gate region; other site 698761014388 putative PBP binding loops; other site 698761014389 ABC-ATPase subunit interface; other site 698761014390 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761014391 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 698761014392 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698761014393 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761014394 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 698761014395 active site 698761014396 catalytic residues [active] 698761014397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761014398 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698761014399 hypothetical protein; Provisional; Region: PRK07208 698761014400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761014401 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 698761014402 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 698761014403 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 698761014404 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698761014405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698761014406 active site 698761014407 Chain length determinant protein; Region: Wzz; pfam02706 698761014408 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 698761014409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761014410 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761014411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761014412 S-adenosylmethionine binding site [chemical binding]; other site 698761014413 Bacterial sugar transferase; Region: Bac_transf; pfam02397 698761014414 Homeodomain-like domain; Region: HTH_23; pfam13384 698761014415 Winged helix-turn helix; Region: HTH_29; pfam13551 698761014416 Homeodomain-like domain; Region: HTH_32; pfam13565 698761014417 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698761014418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761014419 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 698761014420 putative ADP-binding pocket [chemical binding]; other site 698761014421 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698761014422 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698761014423 SLBB domain; Region: SLBB; pfam10531 698761014424 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 698761014425 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 698761014426 Predicted membrane protein [Function unknown]; Region: COG2259 698761014427 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761014428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761014429 DNA-binding site [nucleotide binding]; DNA binding site 698761014430 FCD domain; Region: FCD; pfam07729 698761014431 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698761014432 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698761014433 inhibitor site; inhibition site 698761014434 active site 698761014435 dimer interface [polypeptide binding]; other site 698761014436 catalytic residue [active] 698761014437 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 698761014438 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761014439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761014440 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761014441 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 698761014442 FOG: WD40-like repeat [Function unknown]; Region: COG1520 698761014443 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 698761014444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761014445 putative substrate translocation pore; other site 698761014446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761014447 ATP binding site [chemical binding]; other site 698761014448 Mg2+ binding site [ion binding]; other site 698761014449 G-X-G motif; other site 698761014450 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 698761014451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761014452 active site 698761014453 phosphorylation site [posttranslational modification] 698761014454 intermolecular recognition site; other site 698761014455 dimerization interface [polypeptide binding]; other site 698761014456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761014457 Walker A motif; other site 698761014458 ATP binding site [chemical binding]; other site 698761014459 Walker B motif; other site 698761014460 arginine finger; other site 698761014461 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698761014462 CopC domain; Region: CopC; pfam04234 698761014463 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 698761014464 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 698761014465 Cu(I) binding site [ion binding]; other site 698761014466 Protein of unknown function (DUF461); Region: DUF461; pfam04314 698761014467 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698761014468 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 698761014469 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 698761014470 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 698761014471 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 698761014472 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761014473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761014474 metal binding site [ion binding]; metal-binding site 698761014475 active site 698761014476 I-site; other site 698761014477 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698761014478 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698761014479 putative ligand binding residues [chemical binding]; other site 698761014480 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698761014481 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698761014482 ABC-ATPase subunit interface; other site 698761014483 dimer interface [polypeptide binding]; other site 698761014484 putative PBP binding regions; other site 698761014485 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698761014486 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698761014487 Walker A/P-loop; other site 698761014488 ATP binding site [chemical binding]; other site 698761014489 Q-loop/lid; other site 698761014490 ABC transporter signature motif; other site 698761014491 Walker B; other site 698761014492 D-loop; other site 698761014493 H-loop/switch region; other site 698761014494 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 698761014495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 698761014496 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761014497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761014498 DNA binding residues [nucleotide binding] 698761014499 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 698761014500 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 698761014501 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 698761014502 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 698761014503 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 698761014504 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761014505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761014506 Walker A/P-loop; other site 698761014507 ATP binding site [chemical binding]; other site 698761014508 Q-loop/lid; other site 698761014509 ABC transporter signature motif; other site 698761014510 Walker B; other site 698761014511 D-loop; other site 698761014512 H-loop/switch region; other site 698761014513 TOBE domain; Region: TOBE_2; pfam08402 698761014514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761014515 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698761014516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014517 dimer interface [polypeptide binding]; other site 698761014518 conserved gate region; other site 698761014519 putative PBP binding loops; other site 698761014520 ABC-ATPase subunit interface; other site 698761014521 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761014522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014523 dimer interface [polypeptide binding]; other site 698761014524 conserved gate region; other site 698761014525 putative PBP binding loops; other site 698761014526 ABC-ATPase subunit interface; other site 698761014527 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698761014528 Predicted membrane protein [Function unknown]; Region: COG4655 698761014529 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 698761014530 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 698761014531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761014532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761014533 homodimer interface [polypeptide binding]; other site 698761014534 catalytic residue [active] 698761014535 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 698761014536 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698761014537 E3 interaction surface; other site 698761014538 lipoyl attachment site [posttranslational modification]; other site 698761014539 e3 binding domain; Region: E3_binding; pfam02817 698761014540 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698761014541 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 698761014542 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698761014543 tetramer interface [polypeptide binding]; other site 698761014544 TPP-binding site [chemical binding]; other site 698761014545 heterodimer interface [polypeptide binding]; other site 698761014546 phosphorylation loop region [posttranslational modification] 698761014547 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698761014548 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698761014549 alpha subunit interface [polypeptide binding]; other site 698761014550 TPP binding site [chemical binding]; other site 698761014551 heterodimer interface [polypeptide binding]; other site 698761014552 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698761014553 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761014554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761014555 putative DNA binding site [nucleotide binding]; other site 698761014556 putative Zn2+ binding site [ion binding]; other site 698761014557 AsnC family; Region: AsnC_trans_reg; pfam01037 698761014558 PaaX-like protein; Region: PaaX; pfam07848 698761014559 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 698761014560 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 698761014561 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 698761014562 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 698761014563 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 698761014564 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 698761014565 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698761014566 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 698761014567 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 698761014568 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 698761014569 FAD binding pocket [chemical binding]; other site 698761014570 FAD binding motif [chemical binding]; other site 698761014571 phosphate binding motif [ion binding]; other site 698761014572 beta-alpha-beta structure motif; other site 698761014573 NAD(p) ribose binding residues [chemical binding]; other site 698761014574 NAD binding pocket [chemical binding]; other site 698761014575 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 698761014576 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761014577 catalytic loop [active] 698761014578 iron binding site [ion binding]; other site 698761014579 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 698761014580 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 698761014581 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 698761014582 substrate binding site [chemical binding]; other site 698761014583 dimer interface [polypeptide binding]; other site 698761014584 NADP binding site [chemical binding]; other site 698761014585 catalytic residues [active] 698761014586 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 698761014587 substrate binding site [chemical binding]; other site 698761014588 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 698761014589 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 698761014590 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698761014591 putative trimer interface [polypeptide binding]; other site 698761014592 putative CoA binding site [chemical binding]; other site 698761014593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761014594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761014595 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 698761014596 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 698761014597 active site 698761014598 AMP binding site [chemical binding]; other site 698761014599 homodimer interface [polypeptide binding]; other site 698761014600 acyl-activating enzyme (AAE) consensus motif; other site 698761014601 CoA binding site [chemical binding]; other site 698761014602 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698761014603 CoenzymeA binding site [chemical binding]; other site 698761014604 subunit interaction site [polypeptide binding]; other site 698761014605 PHB binding site; other site 698761014606 enoyl-CoA hydratase; Provisional; Region: PRK08140 698761014607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761014608 substrate binding site [chemical binding]; other site 698761014609 oxyanion hole (OAH) forming residues; other site 698761014610 trimer interface [polypeptide binding]; other site 698761014611 MEKHLA domain; Region: MEKHLA; pfam08670 698761014612 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 698761014613 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761014614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761014615 active site 698761014616 phosphorylation site [posttranslational modification] 698761014617 intermolecular recognition site; other site 698761014618 dimerization interface [polypeptide binding]; other site 698761014619 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761014620 DNA binding residues [nucleotide binding] 698761014621 dimerization interface [polypeptide binding]; other site 698761014622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698761014623 Histidine kinase; Region: HisKA_3; pfam07730 698761014624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761014625 ATP binding site [chemical binding]; other site 698761014626 Mg2+ binding site [ion binding]; other site 698761014627 G-X-G motif; other site 698761014628 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698761014629 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761014630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761014631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761014632 dimerization interface [polypeptide binding]; other site 698761014633 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 698761014634 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698761014635 DNA-binding site [nucleotide binding]; DNA binding site 698761014636 RNA-binding motif; other site 698761014637 CheW-like domain; Region: CheW; pfam01584 698761014638 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 698761014639 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 698761014640 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698761014641 FtsX-like permease family; Region: FtsX; pfam02687 698761014642 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698761014643 FtsX-like permease family; Region: FtsX; pfam02687 698761014644 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761014645 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698761014646 Walker A/P-loop; other site 698761014647 ATP binding site [chemical binding]; other site 698761014648 Q-loop/lid; other site 698761014649 ABC transporter signature motif; other site 698761014650 Walker B; other site 698761014651 D-loop; other site 698761014652 H-loop/switch region; other site 698761014653 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761014654 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761014655 Helix-turn-helix domain; Region: HTH_18; pfam12833 698761014656 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 698761014657 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 698761014658 [4Fe-4S] binding site [ion binding]; other site 698761014659 molybdopterin cofactor binding site; other site 698761014660 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 698761014661 molybdopterin cofactor binding site; other site 698761014662 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698761014663 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 698761014664 [2Fe-2S] cluster binding site [ion binding]; other site 698761014665 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 698761014666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761014667 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698761014668 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698761014669 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698761014670 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761014671 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761014672 Walker A/P-loop; other site 698761014673 ATP binding site [chemical binding]; other site 698761014674 Q-loop/lid; other site 698761014675 ABC transporter signature motif; other site 698761014676 Walker B; other site 698761014677 D-loop; other site 698761014678 H-loop/switch region; other site 698761014679 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761014680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014681 putative PBP binding loops; other site 698761014682 dimer interface [polypeptide binding]; other site 698761014683 ABC-ATPase subunit interface; other site 698761014684 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698761014685 NMT1-like family; Region: NMT1_2; pfam13379 698761014686 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698761014687 NMT1-like family; Region: NMT1_2; pfam13379 698761014688 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 698761014689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761014690 active site 698761014691 phosphorylation site [posttranslational modification] 698761014692 intermolecular recognition site; other site 698761014693 ANTAR domain; Region: ANTAR; pfam03861 698761014694 Isochorismatase family; Region: Isochorismatase; pfam00857 698761014695 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698761014696 catalytic triad [active] 698761014697 conserved cis-peptide bond; other site 698761014698 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761014699 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698761014700 substrate binding site [chemical binding]; other site 698761014701 ATP binding site [chemical binding]; other site 698761014702 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 698761014703 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698761014704 classical (c) SDRs; Region: SDR_c; cd05233 698761014705 NAD(P) binding site [chemical binding]; other site 698761014706 active site 698761014707 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698761014708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698761014709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761014710 S-adenosylmethionine binding site [chemical binding]; other site 698761014711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698761014712 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761014713 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 698761014714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761014715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761014716 active site 698761014717 phosphorylation site [posttranslational modification] 698761014718 intermolecular recognition site; other site 698761014719 dimerization interface [polypeptide binding]; other site 698761014720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761014721 DNA binding site [nucleotide binding] 698761014722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761014723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761014724 dimer interface [polypeptide binding]; other site 698761014725 phosphorylation site [posttranslational modification] 698761014726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761014727 ATP binding site [chemical binding]; other site 698761014728 Mg2+ binding site [ion binding]; other site 698761014729 G-X-G motif; other site 698761014730 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 698761014731 hypothetical protein; Provisional; Region: PRK11171 698761014732 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 698761014733 Cupin domain; Region: Cupin_2; pfam07883 698761014734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761014735 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761014736 DNA binding site [nucleotide binding] 698761014737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761014738 TPR motif; other site 698761014739 binding surface 698761014740 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761014741 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698761014742 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 698761014743 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 698761014744 Chain length determinant protein; Region: Wzz; pfam02706 698761014745 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 698761014746 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 698761014747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761014748 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 698761014749 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 698761014750 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761014751 transcription elongation factor regulatory protein; Validated; Region: PRK06342 698761014752 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698761014753 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761014754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761014755 S-adenosylmethionine binding site [chemical binding]; other site 698761014756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698761014757 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761014758 Cation efflux family; Region: Cation_efflux; cl00316 698761014759 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761014760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761014761 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761014762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761014763 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698761014764 Cytochrome P450; Region: p450; cl12078 698761014765 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698761014766 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761014767 catalytic loop [active] 698761014768 iron binding site [ion binding]; other site 698761014769 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 698761014770 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 698761014771 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 698761014772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761014773 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761014774 NAD(P) binding site [chemical binding]; other site 698761014775 active site 698761014776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761014777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761014778 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 698761014779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761014780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761014781 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761014782 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761014783 Protein of unknown function (DUF993); Region: DUF993; pfam06187 698761014784 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761014785 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698761014786 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 698761014787 dimerization interface [polypeptide binding]; other site 698761014788 ligand binding site [chemical binding]; other site 698761014789 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 698761014790 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 698761014791 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698761014792 N- and C-terminal domain interface [polypeptide binding]; other site 698761014793 putative active site [active] 698761014794 putative MgATP binding site [chemical binding]; other site 698761014795 putative catalytic site [active] 698761014796 metal binding site [ion binding]; metal-binding site 698761014797 putative carbohydrate binding site [chemical binding]; other site 698761014798 Domain of unknown function (DUF718); Region: DUF718; pfam05336 698761014799 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761014800 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761014801 TM-ABC transporter signature motif; other site 698761014802 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761014803 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761014804 TM-ABC transporter signature motif; other site 698761014805 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761014806 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761014807 Walker A/P-loop; other site 698761014808 ATP binding site [chemical binding]; other site 698761014809 Q-loop/lid; other site 698761014810 ABC transporter signature motif; other site 698761014811 Walker B; other site 698761014812 D-loop; other site 698761014813 H-loop/switch region; other site 698761014814 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761014815 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 698761014816 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 698761014817 ligand binding site [chemical binding]; other site 698761014818 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761014819 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698761014820 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761014821 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 698761014822 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 698761014823 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 698761014824 putative NAD(P) binding site [chemical binding]; other site 698761014825 active site 698761014826 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 698761014827 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 698761014828 Predicted transcriptional regulator [Transcription]; Region: COG2378 698761014829 HTH domain; Region: HTH_11; pfam08279 698761014830 WYL domain; Region: WYL; pfam13280 698761014831 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761014832 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698761014833 active site 698761014834 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 698761014835 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 698761014836 catalytic residue [active] 698761014837 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761014838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761014839 S-adenosylmethionine binding site [chemical binding]; other site 698761014840 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698761014841 catalytic residues [active] 698761014842 dimer interface [polypeptide binding]; other site 698761014843 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698761014844 active site 698761014845 Int/Topo IB signature motif; other site 698761014846 DNA binding site [nucleotide binding] 698761014847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698761014848 Integrase core domain; Region: rve; pfam00665 698761014849 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 698761014850 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 698761014851 acyl-activating enzyme (AAE) consensus motif; other site 698761014852 putative AMP binding site [chemical binding]; other site 698761014853 putative active site [active] 698761014854 putative CoA binding site [chemical binding]; other site 698761014855 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698761014856 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698761014857 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698761014858 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698761014859 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 698761014860 putative hydrophobic ligand binding site [chemical binding]; other site 698761014861 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698761014862 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698761014863 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761014864 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 698761014865 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761014866 hypothetical protein; Provisional; Region: PRK06847 698761014867 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761014868 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 698761014869 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 698761014870 active site 698761014871 Fe(II) binding site [ion binding]; other site 698761014872 dimer interface [polypeptide binding]; other site 698761014873 tetramer interface [polypeptide binding]; other site 698761014874 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 698761014875 dimer interface [polypeptide binding]; other site 698761014876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761014877 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 698761014878 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761014879 classical (c) SDRs; Region: SDR_c; cd05233 698761014880 NAD(P) binding site [chemical binding]; other site 698761014881 active site 698761014882 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698761014883 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698761014884 TM-ABC transporter signature motif; other site 698761014885 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698761014886 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761014887 TM-ABC transporter signature motif; other site 698761014888 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698761014889 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698761014890 Walker A/P-loop; other site 698761014891 ATP binding site [chemical binding]; other site 698761014892 Q-loop/lid; other site 698761014893 ABC transporter signature motif; other site 698761014894 Walker B; other site 698761014895 D-loop; other site 698761014896 H-loop/switch region; other site 698761014897 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761014898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761014899 Walker A/P-loop; other site 698761014900 ATP binding site [chemical binding]; other site 698761014901 Q-loop/lid; other site 698761014902 ABC transporter signature motif; other site 698761014903 Walker B; other site 698761014904 D-loop; other site 698761014905 H-loop/switch region; other site 698761014906 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 698761014907 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 698761014908 putative ligand binding site [chemical binding]; other site 698761014909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761014910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761014911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761014912 Transposase; Region: HTH_Tnp_1; pfam01527 698761014913 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761014914 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761014915 Walker A/P-loop; other site 698761014916 ATP binding site [chemical binding]; other site 698761014917 Q-loop/lid; other site 698761014918 ABC transporter signature motif; other site 698761014919 Walker B; other site 698761014920 D-loop; other site 698761014921 H-loop/switch region; other site 698761014922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698761014923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761014924 Walker A/P-loop; other site 698761014925 ATP binding site [chemical binding]; other site 698761014926 Q-loop/lid; other site 698761014927 ABC transporter signature motif; other site 698761014928 Walker B; other site 698761014929 D-loop; other site 698761014930 H-loop/switch region; other site 698761014931 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698761014932 Uncharacterized conserved protein [Function unknown]; Region: COG3342 698761014933 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 698761014934 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 698761014935 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 698761014936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761014937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014938 dimer interface [polypeptide binding]; other site 698761014939 conserved gate region; other site 698761014940 putative PBP binding loops; other site 698761014941 ABC-ATPase subunit interface; other site 698761014942 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761014943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761014944 dimer interface [polypeptide binding]; other site 698761014945 conserved gate region; other site 698761014946 putative PBP binding loops; other site 698761014947 ABC-ATPase subunit interface; other site 698761014948 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 698761014949 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698761014950 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761014951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761014952 DNA-binding site [nucleotide binding]; DNA binding site 698761014953 FCD domain; Region: FCD; pfam07729 698761014954 Uncharacterized conserved protein [Function unknown]; Region: COG5476 698761014955 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 698761014956 MlrC C-terminus; Region: MlrC_C; pfam07171 698761014957 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 698761014958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761014959 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 698761014960 DNA-binding site [nucleotide binding]; DNA binding site 698761014961 FCD domain; Region: FCD; pfam07729 698761014962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761014963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761014964 putative substrate translocation pore; other site 698761014965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761014966 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698761014967 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 698761014968 inhibitor binding site; inhibition site 698761014969 catalytic Zn binding site [ion binding]; other site 698761014970 structural Zn binding site [ion binding]; other site 698761014971 NADP binding site [chemical binding]; other site 698761014972 tetramer interface [polypeptide binding]; other site 698761014973 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698761014974 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698761014975 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761014976 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698761014977 ligand binding site [chemical binding]; other site 698761014978 flexible hinge region; other site 698761014979 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 698761014980 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698761014981 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 698761014982 conserved cys residue [active] 698761014983 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 698761014984 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 698761014985 conserved cys residue [active] 698761014986 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698761014987 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 698761014988 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761014989 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761014990 heat shock protein 90; Provisional; Region: PRK05218 698761014991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761014992 ATP binding site [chemical binding]; other site 698761014993 Mg2+ binding site [ion binding]; other site 698761014994 G-X-G motif; other site 698761014995 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 698761014996 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 698761014997 FAD binding pocket [chemical binding]; other site 698761014998 FAD binding motif [chemical binding]; other site 698761014999 phosphate binding motif [ion binding]; other site 698761015000 NAD binding pocket [chemical binding]; other site 698761015001 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 698761015002 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761015003 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 698761015004 Walker A/P-loop; other site 698761015005 ATP binding site [chemical binding]; other site 698761015006 Q-loop/lid; other site 698761015007 ABC transporter signature motif; other site 698761015008 Walker B; other site 698761015009 D-loop; other site 698761015010 H-loop/switch region; other site 698761015011 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698761015012 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 698761015013 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761015014 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 698761015015 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 698761015016 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 698761015017 active site 698761015018 catalytic residues [active] 698761015019 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 698761015020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698761015021 DNA-binding site [nucleotide binding]; DNA binding site 698761015022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698761015023 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 698761015024 FCD domain; Region: FCD; pfam07729 698761015025 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698761015026 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 698761015027 putative NAD(P) binding site [chemical binding]; other site 698761015028 catalytic Zn binding site [ion binding]; other site 698761015029 structural Zn binding site [ion binding]; other site 698761015030 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761015031 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 698761015032 Serine hydrolase; Region: Ser_hydrolase; pfam06821 698761015033 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698761015034 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 698761015035 dimer interface [polypeptide binding]; other site 698761015036 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698761015037 catalytic triad [active] 698761015038 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761015039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761015040 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761015041 dimerization interface [polypeptide binding]; other site 698761015042 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761015043 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761015044 active site 698761015045 catalytic tetrad [active] 698761015046 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761015047 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761015048 active site 698761015049 catalytic tetrad [active] 698761015050 recombination regulator RecX; Reviewed; Region: recX; PRK00117 698761015051 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 698761015052 hypothetical protein; Validated; Region: PRK08245 698761015053 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 698761015054 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761015055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015056 putative PBP binding loops; other site 698761015057 dimer interface [polypeptide binding]; other site 698761015058 ABC-ATPase subunit interface; other site 698761015059 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761015060 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761015061 Walker A/P-loop; other site 698761015062 ATP binding site [chemical binding]; other site 698761015063 Q-loop/lid; other site 698761015064 ABC transporter signature motif; other site 698761015065 Walker B; other site 698761015066 D-loop; other site 698761015067 H-loop/switch region; other site 698761015068 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 698761015069 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761015070 substrate binding pocket [chemical binding]; other site 698761015071 membrane-bound complex binding site; other site 698761015072 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761015073 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761015074 DNA-binding site [nucleotide binding]; DNA binding site 698761015075 FCD domain; Region: FCD; pfam07729 698761015076 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 698761015077 quinolinate synthetase; Provisional; Region: PRK09375 698761015078 L-aspartate oxidase; Provisional; Region: PRK07512 698761015079 L-aspartate oxidase; Provisional; Region: PRK06175 698761015080 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698761015081 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 698761015082 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698761015083 dimerization interface [polypeptide binding]; other site 698761015084 active site 698761015085 short chain dehydrogenase; Provisional; Region: PRK06125 698761015086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761015087 NAD(P) binding site [chemical binding]; other site 698761015088 active site 698761015089 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698761015090 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698761015091 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698761015092 putative active site [active] 698761015093 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698761015094 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698761015095 hinge; other site 698761015096 active site 698761015097 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 698761015098 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 698761015099 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 698761015100 putative active site [active] 698761015101 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761015102 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 698761015103 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761015104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015105 dimer interface [polypeptide binding]; other site 698761015106 conserved gate region; other site 698761015107 putative PBP binding loops; other site 698761015108 ABC-ATPase subunit interface; other site 698761015109 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698761015110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015111 dimer interface [polypeptide binding]; other site 698761015112 conserved gate region; other site 698761015113 putative PBP binding loops; other site 698761015114 ABC-ATPase subunit interface; other site 698761015115 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761015116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015117 Walker A/P-loop; other site 698761015118 ATP binding site [chemical binding]; other site 698761015119 Q-loop/lid; other site 698761015120 ABC transporter signature motif; other site 698761015121 Walker B; other site 698761015122 D-loop; other site 698761015123 H-loop/switch region; other site 698761015124 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761015125 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015126 Walker A/P-loop; other site 698761015127 ATP binding site [chemical binding]; other site 698761015128 Q-loop/lid; other site 698761015129 ABC transporter signature motif; other site 698761015130 Walker B; other site 698761015131 D-loop; other site 698761015132 H-loop/switch region; other site 698761015133 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761015134 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698761015135 Beta-lactamase; Region: Beta-lactamase; pfam00144 698761015136 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 698761015137 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698761015138 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698761015139 catalytic residue [active] 698761015140 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 698761015141 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 698761015142 putative molybdopterin cofactor binding site [chemical binding]; other site 698761015143 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 698761015144 putative molybdopterin cofactor binding site; other site 698761015145 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761015146 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761015147 Walker A/P-loop; other site 698761015148 ATP binding site [chemical binding]; other site 698761015149 Q-loop/lid; other site 698761015150 ABC transporter signature motif; other site 698761015151 Walker B; other site 698761015152 D-loop; other site 698761015153 H-loop/switch region; other site 698761015154 TOBE domain; Region: TOBE_2; pfam08402 698761015155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 698761015156 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 698761015157 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761015158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015159 dimer interface [polypeptide binding]; other site 698761015160 conserved gate region; other site 698761015161 putative PBP binding loops; other site 698761015162 ABC-ATPase subunit interface; other site 698761015163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015164 dimer interface [polypeptide binding]; other site 698761015165 conserved gate region; other site 698761015166 putative PBP binding loops; other site 698761015167 ABC-ATPase subunit interface; other site 698761015168 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761015169 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761015170 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761015171 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761015172 DNA binding site [nucleotide binding] 698761015173 domain linker motif; other site 698761015174 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698761015175 dimerization interface [polypeptide binding]; other site 698761015176 ligand binding site [chemical binding]; other site 698761015177 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 698761015178 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 698761015179 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 698761015180 Glutamate binding site [chemical binding]; other site 698761015181 NAD binding site [chemical binding]; other site 698761015182 catalytic residues [active] 698761015183 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 698761015184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761015185 dimerization interface [polypeptide binding]; other site 698761015186 putative Zn2+ binding site [ion binding]; other site 698761015187 putative DNA binding site [nucleotide binding]; other site 698761015188 AsnC family; Region: AsnC_trans_reg; pfam01037 698761015189 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 698761015190 active site 1 [active] 698761015191 dimer interface [polypeptide binding]; other site 698761015192 hexamer interface [polypeptide binding]; other site 698761015193 active site 2 [active] 698761015194 LysR family transcriptional regulator; Provisional; Region: PRK14997 698761015195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761015196 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 698761015197 putative effector binding pocket; other site 698761015198 putative dimerization interface [polypeptide binding]; other site 698761015199 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761015200 domain linker motif; other site 698761015201 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 698761015202 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761015203 putative ligand binding site [chemical binding]; other site 698761015204 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761015205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761015206 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 698761015207 dimerization interface [polypeptide binding]; other site 698761015208 substrate binding pocket [chemical binding]; other site 698761015209 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 698761015210 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698761015211 thiamine phosphate binding site [chemical binding]; other site 698761015212 active site 698761015213 pyrophosphate binding site [ion binding]; other site 698761015214 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698761015215 ThiS interaction site; other site 698761015216 putative active site [active] 698761015217 tetramer interface [polypeptide binding]; other site 698761015218 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698761015219 thiS-thiF/thiG interaction site; other site 698761015220 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698761015221 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698761015222 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698761015223 ThiC-associated domain; Region: ThiC-associated; pfam13667 698761015224 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 698761015225 Porin subfamily; Region: Porin_2; pfam02530 698761015226 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 698761015227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761015228 RNA polymerase sigma factor; Reviewed; Region: PRK05602 698761015229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761015230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761015231 DNA binding residues [nucleotide binding] 698761015232 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 698761015233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 698761015234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 698761015235 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761015236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761015237 putative substrate translocation pore; other site 698761015238 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761015239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761015240 DNA-binding site [nucleotide binding]; DNA binding site 698761015241 FCD domain; Region: FCD; pfam07729 698761015242 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698761015243 Aspartase; Region: Aspartase; cd01357 698761015244 active sites [active] 698761015245 tetramer interface [polypeptide binding]; other site 698761015246 L-asparagine permease; Provisional; Region: PRK15049 698761015247 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698761015248 active site 698761015249 homotetramer interface [polypeptide binding]; other site 698761015250 homodimer interface [polypeptide binding]; other site 698761015251 isocitrate lyase; Provisional; Region: PRK15063 698761015252 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 698761015253 tetramer interface [polypeptide binding]; other site 698761015254 active site 698761015255 Mg2+/Mn2+ binding site [ion binding]; other site 698761015256 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761015257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761015258 non-specific DNA binding site [nucleotide binding]; other site 698761015259 salt bridge; other site 698761015260 sequence-specific DNA binding site [nucleotide binding]; other site 698761015261 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698761015262 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698761015263 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698761015264 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 698761015265 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698761015266 substrate binding site [chemical binding]; other site 698761015267 ATP binding site [chemical binding]; other site 698761015268 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761015269 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761015270 Walker A/P-loop; other site 698761015271 ATP binding site [chemical binding]; other site 698761015272 Q-loop/lid; other site 698761015273 ABC transporter signature motif; other site 698761015274 Walker B; other site 698761015275 D-loop; other site 698761015276 H-loop/switch region; other site 698761015277 TOBE domain; Region: TOBE_2; pfam08402 698761015278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761015279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015280 putative PBP binding loops; other site 698761015281 dimer interface [polypeptide binding]; other site 698761015282 ABC-ATPase subunit interface; other site 698761015283 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698761015284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015285 dimer interface [polypeptide binding]; other site 698761015286 conserved gate region; other site 698761015287 putative PBP binding loops; other site 698761015288 ABC-ATPase subunit interface; other site 698761015289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761015290 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761015291 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761015292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698761015293 DNA-binding site [nucleotide binding]; DNA binding site 698761015294 FCD domain; Region: FCD; pfam07729 698761015295 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698761015296 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698761015297 inhibitor site; inhibition site 698761015298 active site 698761015299 dimer interface [polypeptide binding]; other site 698761015300 catalytic residue [active] 698761015301 cytosine deaminase; Validated; Region: PRK07572 698761015302 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 698761015303 active site 698761015304 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761015305 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761015306 TM-ABC transporter signature motif; other site 698761015307 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761015308 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761015309 TM-ABC transporter signature motif; other site 698761015310 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698761015311 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761015312 Walker A/P-loop; other site 698761015313 ATP binding site [chemical binding]; other site 698761015314 Q-loop/lid; other site 698761015315 ABC transporter signature motif; other site 698761015316 Walker B; other site 698761015317 D-loop; other site 698761015318 H-loop/switch region; other site 698761015319 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761015320 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698761015321 Amidase; Region: Amidase; cl11426 698761015322 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 698761015323 putative ligand binding site [chemical binding]; other site 698761015324 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698761015325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761015326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761015327 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 698761015328 putative dimer interface [polypeptide binding]; other site 698761015329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761015330 KTSC domain; Region: KTSC; pfam13619 698761015331 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 698761015332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761015333 putative substrate translocation pore; other site 698761015334 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 698761015335 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 698761015336 active site pocket [active] 698761015337 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761015338 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015339 Walker A/P-loop; other site 698761015340 ATP binding site [chemical binding]; other site 698761015341 Q-loop/lid; other site 698761015342 ABC transporter signature motif; other site 698761015343 Walker B; other site 698761015344 D-loop; other site 698761015345 H-loop/switch region; other site 698761015346 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761015347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015348 Walker A/P-loop; other site 698761015349 ATP binding site [chemical binding]; other site 698761015350 Q-loop/lid; other site 698761015351 ABC transporter signature motif; other site 698761015352 Walker B; other site 698761015353 D-loop; other site 698761015354 H-loop/switch region; other site 698761015355 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761015356 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761015357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015358 dimer interface [polypeptide binding]; other site 698761015359 conserved gate region; other site 698761015360 putative PBP binding loops; other site 698761015361 ABC-ATPase subunit interface; other site 698761015362 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761015363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015364 ABC-ATPase subunit interface; other site 698761015365 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 698761015366 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698761015367 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761015368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761015369 DNA-binding site [nucleotide binding]; DNA binding site 698761015370 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698761015371 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698761015372 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698761015373 inhibitor site; inhibition site 698761015374 active site 698761015375 dimer interface [polypeptide binding]; other site 698761015376 catalytic residue [active] 698761015377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698761015378 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 698761015379 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 698761015380 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761015381 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761015382 active site 698761015383 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761015384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761015385 non-specific DNA binding site [nucleotide binding]; other site 698761015386 salt bridge; other site 698761015387 sequence-specific DNA binding site [nucleotide binding]; other site 698761015388 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 698761015389 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698761015390 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698761015391 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698761015392 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 698761015393 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 698761015394 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 698761015395 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698761015396 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 698761015397 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 698761015398 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 698761015399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761015400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761015401 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698761015402 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698761015403 active site 698761015404 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 698761015405 SnoaL-like domain; Region: SnoaL_3; pfam13474 698761015406 SnoaL-like domain; Region: SnoaL_2; pfam12680 698761015407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761015408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761015409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761015410 dimerization interface [polypeptide binding]; other site 698761015411 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232 698761015412 putative active site [active] 698761015413 Zn binding site [ion binding]; other site 698761015414 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761015415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015416 dimer interface [polypeptide binding]; other site 698761015417 conserved gate region; other site 698761015418 putative PBP binding loops; other site 698761015419 ABC-ATPase subunit interface; other site 698761015420 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761015421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015422 dimer interface [polypeptide binding]; other site 698761015423 conserved gate region; other site 698761015424 ABC-ATPase subunit interface; other site 698761015425 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761015426 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698761015427 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761015428 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015429 Walker A/P-loop; other site 698761015430 ATP binding site [chemical binding]; other site 698761015431 Q-loop/lid; other site 698761015432 ABC transporter signature motif; other site 698761015433 Walker B; other site 698761015434 D-loop; other site 698761015435 H-loop/switch region; other site 698761015436 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698761015437 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015438 Walker A/P-loop; other site 698761015439 ATP binding site [chemical binding]; other site 698761015440 Q-loop/lid; other site 698761015441 ABC transporter signature motif; other site 698761015442 Walker B; other site 698761015443 D-loop; other site 698761015444 H-loop/switch region; other site 698761015445 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698761015446 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761015447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761015448 DNA-binding site [nucleotide binding]; DNA binding site 698761015449 FCD domain; Region: FCD; pfam07729 698761015450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761015451 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761015452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761015453 DNA-binding site [nucleotide binding]; DNA binding site 698761015454 FCD domain; Region: FCD; pfam07729 698761015455 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 698761015456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761015457 putative substrate translocation pore; other site 698761015458 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 698761015459 Predicted transcriptional regulators [Transcription]; Region: COG1695 698761015460 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 698761015461 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 698761015462 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 698761015463 MarR family; Region: MarR_2; cl17246 698761015464 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761015465 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 698761015466 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 698761015467 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698761015468 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698761015469 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 698761015470 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698761015471 tetramerization interface [polypeptide binding]; other site 698761015472 NAD(P) binding site [chemical binding]; other site 698761015473 catalytic residues [active] 698761015474 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 698761015475 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 698761015476 tetramer interface [polypeptide binding]; other site 698761015477 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 698761015478 tetramer interface [polypeptide binding]; other site 698761015479 active site 698761015480 metal binding site [ion binding]; metal-binding site 698761015481 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 698761015482 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 698761015483 NAD binding site [chemical binding]; other site 698761015484 catalytic residues [active] 698761015485 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 698761015486 putative substrate binding pocket [chemical binding]; other site 698761015487 trimer interface [polypeptide binding]; other site 698761015488 Phosphotransferase enzyme family; Region: APH; pfam01636 698761015489 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698761015490 active site 698761015491 ATP binding site [chemical binding]; other site 698761015492 substrate binding site [chemical binding]; other site 698761015493 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 698761015494 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761015495 inhibitor-cofactor binding pocket; inhibition site 698761015496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761015497 catalytic residue [active] 698761015498 hypothetical protein; Provisional; Region: PRK07481 698761015499 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761015500 inhibitor-cofactor binding pocket; inhibition site 698761015501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761015502 catalytic residue [active] 698761015503 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 698761015504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761015505 motif II; other site 698761015506 hypothetical protein; Provisional; Region: PRK02399 698761015507 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 698761015508 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 698761015509 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698761015510 Bacterial transcriptional regulator; Region: IclR; pfam01614 698761015511 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 698761015512 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761015513 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 698761015514 NAD(P) binding site [chemical binding]; other site 698761015515 catalytic residues [active] 698761015516 Flavin Reductases; Region: FlaRed; cl00801 698761015517 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 698761015518 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 698761015519 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 698761015520 Cupin domain; Region: Cupin_2; cl17218 698761015521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761015522 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761015523 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761015524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761015525 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 698761015526 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 698761015527 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 698761015528 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 698761015529 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 698761015530 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761015531 MULE transposase domain; Region: MULE; pfam10551 698761015532 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698761015533 catalytic residues [active] 698761015534 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698761015535 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698761015536 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698761015537 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698761015538 active site 698761015539 dimer interface [polypeptide binding]; other site 698761015540 catalytic residues [active] 698761015541 effector binding site; other site 698761015542 R2 peptide binding site; other site 698761015543 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698761015544 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698761015545 dimer interface [polypeptide binding]; other site 698761015546 putative radical transfer pathway; other site 698761015547 diiron center [ion binding]; other site 698761015548 tyrosyl radical; other site 698761015549 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698761015550 IHF dimer interface [polypeptide binding]; other site 698761015551 IHF - DNA interface [nucleotide binding]; other site 698761015552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 698761015553 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698761015554 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 698761015555 putative NAD(P) binding site [chemical binding]; other site 698761015556 catalytic Zn binding site [ion binding]; other site 698761015557 potassium-transporting ATPase subunit F; Provisional; Region: PRK14759 698761015558 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 698761015559 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 698761015560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698761015561 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698761015562 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 698761015563 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 698761015564 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 698761015565 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 698761015566 Ligand Binding Site [chemical binding]; other site 698761015567 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 698761015568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761015569 dimer interface [polypeptide binding]; other site 698761015570 phosphorylation site [posttranslational modification] 698761015571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761015572 ATP binding site [chemical binding]; other site 698761015573 Mg2+ binding site [ion binding]; other site 698761015574 G-X-G motif; other site 698761015575 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761015576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761015577 active site 698761015578 phosphorylation site [posttranslational modification] 698761015579 intermolecular recognition site; other site 698761015580 dimerization interface [polypeptide binding]; other site 698761015581 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761015582 DNA binding site [nucleotide binding] 698761015583 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698761015584 active site 698761015585 phosphorylation site [posttranslational modification] 698761015586 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698761015587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761015588 substrate binding pocket [chemical binding]; other site 698761015589 membrane-bound complex binding site; other site 698761015590 hinge residues; other site 698761015591 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698761015592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015593 dimer interface [polypeptide binding]; other site 698761015594 conserved gate region; other site 698761015595 putative PBP binding loops; other site 698761015596 ABC-ATPase subunit interface; other site 698761015597 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698761015598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015599 dimer interface [polypeptide binding]; other site 698761015600 conserved gate region; other site 698761015601 putative PBP binding loops; other site 698761015602 ABC-ATPase subunit interface; other site 698761015603 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 698761015604 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 698761015605 Walker A/P-loop; other site 698761015606 ATP binding site [chemical binding]; other site 698761015607 Q-loop/lid; other site 698761015608 ABC transporter signature motif; other site 698761015609 Walker B; other site 698761015610 D-loop; other site 698761015611 H-loop/switch region; other site 698761015612 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698761015613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761015614 NAD(P) binding site [chemical binding]; other site 698761015615 active site 698761015616 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 698761015617 putative catalytic site [active] 698761015618 putative metal binding site [ion binding]; other site 698761015619 putative phosphate binding site [ion binding]; other site 698761015620 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 698761015621 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 698761015622 putative active site [active] 698761015623 catalytic site [active] 698761015624 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 698761015625 putative active site [active] 698761015626 catalytic site [active] 698761015627 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 698761015628 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 698761015629 glutathione s-transferase; Provisional; Region: PTZ00057 698761015630 GSH binding site (G-site) [chemical binding]; other site 698761015631 C-terminal domain interface [polypeptide binding]; other site 698761015632 dimer interface [polypeptide binding]; other site 698761015633 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 698761015634 dimer interface [polypeptide binding]; other site 698761015635 N-terminal domain interface [polypeptide binding]; other site 698761015636 substrate binding pocket (H-site) [chemical binding]; other site 698761015637 Phospholipid methyltransferase; Region: PEMT; cl17370 698761015638 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 698761015639 nucleotide binding site [chemical binding]; other site 698761015640 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 698761015641 classical (c) SDRs; Region: SDR_c; cd05233 698761015642 NAD(P) binding site [chemical binding]; other site 698761015643 active site 698761015644 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698761015645 homotrimer interaction site [polypeptide binding]; other site 698761015646 putative active site [active] 698761015647 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 698761015648 substrate binding site [chemical binding]; other site 698761015649 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761015650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761015651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015652 dimer interface [polypeptide binding]; other site 698761015653 conserved gate region; other site 698761015654 putative PBP binding loops; other site 698761015655 ABC-ATPase subunit interface; other site 698761015656 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761015657 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 698761015658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015659 dimer interface [polypeptide binding]; other site 698761015660 conserved gate region; other site 698761015661 putative PBP binding loops; other site 698761015662 ABC-ATPase subunit interface; other site 698761015663 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698761015664 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015665 Walker A/P-loop; other site 698761015666 ATP binding site [chemical binding]; other site 698761015667 Q-loop/lid; other site 698761015668 ABC transporter signature motif; other site 698761015669 Walker B; other site 698761015670 D-loop; other site 698761015671 H-loop/switch region; other site 698761015672 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761015673 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698761015674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015675 Walker A/P-loop; other site 698761015676 ATP binding site [chemical binding]; other site 698761015677 Q-loop/lid; other site 698761015678 ABC transporter signature motif; other site 698761015679 Walker B; other site 698761015680 D-loop; other site 698761015681 H-loop/switch region; other site 698761015682 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698761015683 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698761015684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761015685 Coenzyme A binding pocket [chemical binding]; other site 698761015686 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 698761015687 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 698761015688 active site 698761015689 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 698761015690 non-specific DNA interactions [nucleotide binding]; other site 698761015691 DNA binding site [nucleotide binding] 698761015692 sequence specific DNA binding site [nucleotide binding]; other site 698761015693 putative cAMP binding site [chemical binding]; other site 698761015694 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761015695 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761015696 nucleotide binding site [chemical binding]; other site 698761015697 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 698761015698 hypothetical protein; Provisional; Region: PRK06753 698761015699 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761015700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761015701 MarR family; Region: MarR_2; pfam12802 698761015702 MarR family; Region: MarR_2; cl17246 698761015703 PAS fold; Region: PAS_7; pfam12860 698761015704 PAS domain S-box; Region: sensory_box; TIGR00229 698761015705 PAS domain; Region: PAS_8; pfam13188 698761015706 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761015707 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761015708 metal binding site [ion binding]; metal-binding site 698761015709 active site 698761015710 I-site; other site 698761015711 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698761015712 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761015713 protein binding site [polypeptide binding]; other site 698761015714 classical (c) SDRs; Region: SDR_c; cd05233 698761015715 NAD(P) binding site [chemical binding]; other site 698761015716 active site 698761015717 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761015718 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 698761015719 putative NAD(P) binding site [chemical binding]; other site 698761015720 active site 698761015721 putative substrate binding site [chemical binding]; other site 698761015722 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 698761015723 putative aldolase; Validated; Region: PRK08130 698761015724 intersubunit interface [polypeptide binding]; other site 698761015725 active site 698761015726 Zn2+ binding site [ion binding]; other site 698761015727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698761015728 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761015729 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761015730 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761015731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761015732 DNA binding site [nucleotide binding] 698761015733 domain linker motif; other site 698761015734 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 698761015735 putative dimerization interface [polypeptide binding]; other site 698761015736 putative ligand binding site [chemical binding]; other site 698761015737 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698761015738 active site 698761015739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761015740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761015741 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 698761015742 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 698761015743 active site 698761015744 dimer interface [polypeptide binding]; other site 698761015745 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698761015746 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698761015747 active site 698761015748 non-prolyl cis peptide bond; other site 698761015749 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761015750 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761015751 TM-ABC transporter signature motif; other site 698761015752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761015753 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761015754 TM-ABC transporter signature motif; other site 698761015755 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761015756 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761015757 Walker A/P-loop; other site 698761015758 ATP binding site [chemical binding]; other site 698761015759 Q-loop/lid; other site 698761015760 ABC transporter signature motif; other site 698761015761 Walker B; other site 698761015762 D-loop; other site 698761015763 H-loop/switch region; other site 698761015764 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761015765 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 698761015766 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761015767 putative ligand binding site [chemical binding]; other site 698761015768 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 698761015769 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761015770 putative ligand binding site [chemical binding]; other site 698761015771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761015772 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761015773 active site 698761015774 cell division protein FtsZ; Validated; Region: PRK09330 698761015775 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698761015776 nucleotide binding site [chemical binding]; other site 698761015777 SulA interaction site; other site 698761015778 Integrase core domain; Region: rve; pfam00665 698761015779 Integrase core domain; Region: rve_2; pfam13333 698761015780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761015781 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761015782 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761015783 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 698761015784 Flavin binding site [chemical binding]; other site 698761015785 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 698761015786 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698761015787 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 698761015788 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761015789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761015790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761015791 dimerization interface [polypeptide binding]; other site 698761015792 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 698761015793 heme-binding site [chemical binding]; other site 698761015794 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761015795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761015796 dimer interface [polypeptide binding]; other site 698761015797 putative CheW interface [polypeptide binding]; other site 698761015798 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698761015799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761015800 putative substrate translocation pore; other site 698761015801 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 698761015802 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698761015803 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 698761015804 Predicted transcriptional regulator [Transcription]; Region: COG4189 698761015805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761015806 dimerization interface [polypeptide binding]; other site 698761015807 putative DNA binding site [nucleotide binding]; other site 698761015808 putative Zn2+ binding site [ion binding]; other site 698761015809 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 698761015810 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 698761015811 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761015812 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 698761015813 substrate binding site [chemical binding]; other site 698761015814 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761015815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015816 dimer interface [polypeptide binding]; other site 698761015817 conserved gate region; other site 698761015818 putative PBP binding loops; other site 698761015819 ABC-ATPase subunit interface; other site 698761015820 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761015821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015822 dimer interface [polypeptide binding]; other site 698761015823 conserved gate region; other site 698761015824 putative PBP binding loops; other site 698761015825 ABC-ATPase subunit interface; other site 698761015826 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698761015827 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015828 Walker A/P-loop; other site 698761015829 ATP binding site [chemical binding]; other site 698761015830 Q-loop/lid; other site 698761015831 ABC transporter signature motif; other site 698761015832 Walker B; other site 698761015833 D-loop; other site 698761015834 H-loop/switch region; other site 698761015835 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698761015836 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698761015837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761015838 Walker A/P-loop; other site 698761015839 ATP binding site [chemical binding]; other site 698761015840 Q-loop/lid; other site 698761015841 ABC transporter signature motif; other site 698761015842 Walker B; other site 698761015843 D-loop; other site 698761015844 H-loop/switch region; other site 698761015845 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761015846 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 698761015847 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 698761015848 AsnC family; Region: AsnC_trans_reg; pfam01037 698761015849 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 698761015850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761015851 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698761015852 FAD binding domain; Region: FAD_binding_4; pfam01565 698761015853 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698761015854 aspartate aminotransferase; Provisional; Region: PRK05764 698761015855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761015856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761015857 homodimer interface [polypeptide binding]; other site 698761015858 catalytic residue [active] 698761015859 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 698761015860 aldehyde dehydrogenase family 7 member; Region: PLN02315 698761015861 tetrameric interface [polypeptide binding]; other site 698761015862 NAD binding site [chemical binding]; other site 698761015863 catalytic residues [active] 698761015864 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 698761015865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 698761015866 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761015867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761015868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761015869 dimerization interface [polypeptide binding]; other site 698761015870 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 698761015871 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698761015872 argininosuccinate synthase; Provisional; Region: PRK13820 698761015873 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698761015874 ANP binding site [chemical binding]; other site 698761015875 Substrate Binding Site II [chemical binding]; other site 698761015876 Substrate Binding Site I [chemical binding]; other site 698761015877 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761015878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761015879 putative DNA binding site [nucleotide binding]; other site 698761015880 putative Zn2+ binding site [ion binding]; other site 698761015881 AsnC family; Region: AsnC_trans_reg; pfam01037 698761015882 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 698761015883 active site 698761015884 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698761015885 dimer interface [polypeptide binding]; other site 698761015886 non-prolyl cis peptide bond; other site 698761015887 insertion regions; other site 698761015888 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698761015889 PAS domain; Region: PAS_9; pfam13426 698761015890 PAS domain; Region: PAS_9; pfam13426 698761015891 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761015892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761015893 metal binding site [ion binding]; metal-binding site 698761015894 active site 698761015895 I-site; other site 698761015896 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698761015897 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698761015898 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698761015899 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 698761015900 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 698761015901 active site 698761015902 dimer interface [polypeptide binding]; other site 698761015903 non-prolyl cis peptide bond; other site 698761015904 insertion regions; other site 698761015905 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761015906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015907 putative PBP binding loops; other site 698761015908 dimer interface [polypeptide binding]; other site 698761015909 ABC-ATPase subunit interface; other site 698761015910 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 698761015911 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761015912 Walker A/P-loop; other site 698761015913 ATP binding site [chemical binding]; other site 698761015914 Q-loop/lid; other site 698761015915 ABC transporter signature motif; other site 698761015916 Walker B; other site 698761015917 D-loop; other site 698761015918 H-loop/switch region; other site 698761015919 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 698761015920 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761015921 substrate binding pocket [chemical binding]; other site 698761015922 membrane-bound complex binding site; other site 698761015923 hinge residues; other site 698761015924 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698761015925 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698761015926 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698761015927 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698761015928 active site 698761015929 non-prolyl cis peptide bond; other site 698761015930 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698761015931 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 698761015932 metal binding site [ion binding]; metal-binding site 698761015933 putative dimer interface [polypeptide binding]; other site 698761015934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761015935 Coenzyme A binding pocket [chemical binding]; other site 698761015936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761015937 dimer interface [polypeptide binding]; other site 698761015938 conserved gate region; other site 698761015939 putative PBP binding loops; other site 698761015940 ABC-ATPase subunit interface; other site 698761015941 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761015942 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761015943 Walker A/P-loop; other site 698761015944 ATP binding site [chemical binding]; other site 698761015945 Q-loop/lid; other site 698761015946 ABC transporter signature motif; other site 698761015947 Walker B; other site 698761015948 D-loop; other site 698761015949 H-loop/switch region; other site 698761015950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761015951 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761015952 substrate binding pocket [chemical binding]; other site 698761015953 membrane-bound complex binding site; other site 698761015954 hinge residues; other site 698761015955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761015956 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761015957 substrate binding pocket [chemical binding]; other site 698761015958 membrane-bound complex binding site; other site 698761015959 hinge residues; other site 698761015960 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698761015961 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698761015962 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 698761015963 hypothetical protein; Provisional; Region: PRK07236 698761015964 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761015965 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761015966 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761015967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761015968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761015969 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698761015970 metal-binding site [ion binding] 698761015971 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 698761015972 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698761015973 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698761015974 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 698761015975 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 698761015976 putative NAD(P) binding site [chemical binding]; other site 698761015977 putative dimer interface [polypeptide binding]; other site 698761015978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761015979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761015980 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 698761015981 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 698761015982 transmembrane helices; other site 698761015983 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698761015984 Ligand Binding Site [chemical binding]; other site 698761015985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 698761015986 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761015987 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761015988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761015989 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 698761015990 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 698761015991 putative ligand binding site [chemical binding]; other site 698761015992 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761015993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761015994 Walker A/P-loop; other site 698761015995 ATP binding site [chemical binding]; other site 698761015996 Q-loop/lid; other site 698761015997 ABC transporter signature motif; other site 698761015998 Walker B; other site 698761015999 D-loop; other site 698761016000 H-loop/switch region; other site 698761016001 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 698761016002 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761016003 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016004 TM-ABC transporter signature motif; other site 698761016005 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698761016006 classical (c) SDRs; Region: SDR_c; cd05233 698761016007 NAD(P) binding site [chemical binding]; other site 698761016008 active site 698761016009 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 698761016010 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 698761016011 N- and C-terminal domain interface [polypeptide binding]; other site 698761016012 active site 698761016013 MgATP binding site [chemical binding]; other site 698761016014 catalytic site [active] 698761016015 metal binding site [ion binding]; metal-binding site 698761016016 carbohydrate binding site [chemical binding]; other site 698761016017 putative homodimer interface [polypeptide binding]; other site 698761016018 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698761016019 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698761016020 Predicted acyl esterases [General function prediction only]; Region: COG2936 698761016021 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761016022 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 698761016023 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698761016024 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761016025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761016026 non-specific DNA binding site [nucleotide binding]; other site 698761016027 salt bridge; other site 698761016028 sequence-specific DNA binding site [nucleotide binding]; other site 698761016029 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698761016030 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761016031 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761016032 Walker A/P-loop; other site 698761016033 ATP binding site [chemical binding]; other site 698761016034 Q-loop/lid; other site 698761016035 ABC transporter signature motif; other site 698761016036 Walker B; other site 698761016037 D-loop; other site 698761016038 H-loop/switch region; other site 698761016039 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761016040 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761016041 Walker A/P-loop; other site 698761016042 ATP binding site [chemical binding]; other site 698761016043 Q-loop/lid; other site 698761016044 ABC transporter signature motif; other site 698761016045 Walker B; other site 698761016046 D-loop; other site 698761016047 H-loop/switch region; other site 698761016048 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698761016049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016050 dimer interface [polypeptide binding]; other site 698761016051 conserved gate region; other site 698761016052 ABC-ATPase subunit interface; other site 698761016053 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761016054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016055 dimer interface [polypeptide binding]; other site 698761016056 conserved gate region; other site 698761016057 ABC-ATPase subunit interface; other site 698761016058 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761016059 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698761016060 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 698761016061 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698761016062 substrate binding site [chemical binding]; other site 698761016063 oxyanion hole (OAH) forming residues; other site 698761016064 trimer interface [polypeptide binding]; other site 698761016065 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 698761016066 CoA binding domain; Region: CoA_binding_2; pfam13380 698761016067 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 698761016068 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 698761016069 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761016070 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761016071 active site 698761016072 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 698761016073 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 698761016074 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 698761016075 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698761016076 active site 698761016077 Uncharacterized conserved protein [Function unknown]; Region: COG3246 698761016078 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698761016079 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 698761016080 conserved cys residue [active] 698761016081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761016082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761016083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761016084 dimerization interface [polypeptide binding]; other site 698761016085 EamA-like transporter family; Region: EamA; pfam00892 698761016086 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 698761016087 EamA-like transporter family; Region: EamA; pfam00892 698761016088 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 698761016089 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 698761016090 putative active site [active] 698761016091 putative FMN binding site [chemical binding]; other site 698761016092 putative substrate binding site [chemical binding]; other site 698761016093 putative catalytic residue [active] 698761016094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761016095 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761016096 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761016097 Walker A/P-loop; other site 698761016098 ATP binding site [chemical binding]; other site 698761016099 Q-loop/lid; other site 698761016100 ABC transporter signature motif; other site 698761016101 Walker B; other site 698761016102 D-loop; other site 698761016103 H-loop/switch region; other site 698761016104 TOBE domain; Region: TOBE_2; pfam08402 698761016105 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 698761016106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761016107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016108 dimer interface [polypeptide binding]; other site 698761016109 conserved gate region; other site 698761016110 putative PBP binding loops; other site 698761016111 ABC-ATPase subunit interface; other site 698761016112 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698761016113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016114 putative PBP binding loops; other site 698761016115 ABC-ATPase subunit interface; other site 698761016116 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761016117 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761016118 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761016119 DAK2 domain; Region: Dak2; cl03685 698761016120 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 698761016121 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698761016122 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761016123 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761016124 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761016125 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761016126 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016127 TM-ABC transporter signature motif; other site 698761016128 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761016129 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761016130 Walker A/P-loop; other site 698761016131 ATP binding site [chemical binding]; other site 698761016132 Q-loop/lid; other site 698761016133 ABC transporter signature motif; other site 698761016134 Walker B; other site 698761016135 D-loop; other site 698761016136 H-loop/switch region; other site 698761016137 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761016138 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 698761016139 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761016140 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 698761016141 ligand binding site [chemical binding]; other site 698761016142 dimerization interface [polypeptide binding]; other site 698761016143 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 698761016144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 698761016145 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 698761016146 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 698761016147 dimer interface [polypeptide binding]; other site 698761016148 active site 698761016149 catalytic residue [active] 698761016150 metal binding site [ion binding]; metal-binding site 698761016151 transcriptional regulator NanR; Provisional; Region: PRK03837 698761016152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761016153 DNA-binding site [nucleotide binding]; DNA binding site 698761016154 FCD domain; Region: FCD; pfam07729 698761016155 Bacitracin resistance protein BacA; Region: BacA; pfam02673 698761016156 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698761016157 dimer interface [polypeptide binding]; other site 698761016158 substrate binding site [chemical binding]; other site 698761016159 ATP binding site [chemical binding]; other site 698761016160 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698761016161 active site 698761016162 thiamine phosphate binding site [chemical binding]; other site 698761016163 pyrophosphate binding site [ion binding]; other site 698761016164 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 698761016165 substrate binding site [chemical binding]; other site 698761016166 multimerization interface [polypeptide binding]; other site 698761016167 ATP binding site [chemical binding]; other site 698761016168 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698761016169 putative S-transferase; Provisional; Region: PRK11752 698761016170 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 698761016171 C-terminal domain interface [polypeptide binding]; other site 698761016172 GSH binding site (G-site) [chemical binding]; other site 698761016173 dimer interface [polypeptide binding]; other site 698761016174 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 698761016175 dimer interface [polypeptide binding]; other site 698761016176 N-terminal domain interface [polypeptide binding]; other site 698761016177 active site 698761016178 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 698761016179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761016180 active site 698761016181 phosphorylation site [posttranslational modification] 698761016182 intermolecular recognition site; other site 698761016183 dimerization interface [polypeptide binding]; other site 698761016184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761016185 Walker A motif; other site 698761016186 ATP binding site [chemical binding]; other site 698761016187 Walker B motif; other site 698761016188 arginine finger; other site 698761016189 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 698761016190 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 698761016191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761016192 dimer interface [polypeptide binding]; other site 698761016193 phosphorylation site [posttranslational modification] 698761016194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761016195 ATP binding site [chemical binding]; other site 698761016196 Mg2+ binding site [ion binding]; other site 698761016197 G-X-G motif; other site 698761016198 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 698761016199 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698761016200 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 698761016201 nudix motif; other site 698761016202 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761016203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761016204 non-specific DNA binding site [nucleotide binding]; other site 698761016205 salt bridge; other site 698761016206 sequence-specific DNA binding site [nucleotide binding]; other site 698761016207 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761016208 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 698761016209 Hint domain; Region: Hint_2; pfam13403 698761016210 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698761016211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761016212 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698761016213 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761016214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761016215 TPR motif; other site 698761016216 TPR repeat; Region: TPR_11; pfam13414 698761016217 binding surface 698761016218 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 698761016219 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698761016220 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698761016221 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 698761016222 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 698761016223 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761016224 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 698761016225 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 698761016226 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698761016227 Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177 698761016228 Walker A/P-loop; other site 698761016229 ATP binding site [chemical binding]; other site 698761016230 Q-loop/lid; other site 698761016231 ABC transporter signature motif; other site 698761016232 Walker B; other site 698761016233 D-loop; other site 698761016234 H-loop/switch region; other site 698761016235 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761016236 MULE transposase domain; Region: MULE; pfam10551 698761016237 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761016238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761016239 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698761016240 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 698761016241 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698761016242 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 698761016243 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761016244 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 698761016245 Autotransporter beta-domain; Region: Autotransporter; cl17461 698761016246 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761016247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761016248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761016249 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 698761016250 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761016251 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698761016252 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 698761016253 active site 698761016254 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761016255 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761016256 Walker A/P-loop; other site 698761016257 ATP binding site [chemical binding]; other site 698761016258 Q-loop/lid; other site 698761016259 ABC transporter signature motif; other site 698761016260 Walker B; other site 698761016261 D-loop; other site 698761016262 H-loop/switch region; other site 698761016263 TOBE domain; Region: TOBE_2; pfam08402 698761016264 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761016265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016266 dimer interface [polypeptide binding]; other site 698761016267 conserved gate region; other site 698761016268 putative PBP binding loops; other site 698761016269 ABC-ATPase subunit interface; other site 698761016270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016271 dimer interface [polypeptide binding]; other site 698761016272 conserved gate region; other site 698761016273 putative PBP binding loops; other site 698761016274 ABC-ATPase subunit interface; other site 698761016275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761016276 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761016277 hypothetical protein; Provisional; Region: PRK05968 698761016278 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698761016279 homodimer interface [polypeptide binding]; other site 698761016280 substrate-cofactor binding pocket; other site 698761016281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761016282 catalytic residue [active] 698761016283 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761016284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761016285 DNA-binding site [nucleotide binding]; DNA binding site 698761016286 FCD domain; Region: FCD; pfam07729 698761016287 cytosine deaminase; Provisional; Region: PRK05985 698761016288 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 698761016289 active site 698761016290 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761016291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761016292 DNA-binding site [nucleotide binding]; DNA binding site 698761016293 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698761016294 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761016295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761016296 Walker A/P-loop; other site 698761016297 ATP binding site [chemical binding]; other site 698761016298 Q-loop/lid; other site 698761016299 ABC transporter signature motif; other site 698761016300 Walker B; other site 698761016301 D-loop; other site 698761016302 H-loop/switch region; other site 698761016303 TOBE domain; Region: TOBE_2; pfam08402 698761016304 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698761016305 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761016306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016307 dimer interface [polypeptide binding]; other site 698761016308 conserved gate region; other site 698761016309 putative PBP binding loops; other site 698761016310 ABC-ATPase subunit interface; other site 698761016311 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761016312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016313 dimer interface [polypeptide binding]; other site 698761016314 conserved gate region; other site 698761016315 putative PBP binding loops; other site 698761016316 ABC-ATPase subunit interface; other site 698761016317 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 698761016318 Uncharacterized conserved protein [Function unknown]; Region: COG1415 698761016319 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 698761016320 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 698761016321 Trp docking motif [polypeptide binding]; other site 698761016322 putative active site [active] 698761016323 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 698761016324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761016325 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761016326 Spore Coat Protein U domain; Region: SCPU; cl02253 698761016327 Uncharacterized secreted protein [Function unknown]; Region: COG5430 698761016328 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 698761016329 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 698761016330 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 698761016331 PapC C-terminal domain; Region: PapC_C; pfam13953 698761016332 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 698761016333 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 698761016334 Uncharacterized secreted protein [Function unknown]; Region: COG5430 698761016335 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 698761016336 peptidase T; Region: peptidase-T; TIGR01882 698761016337 metal binding site [ion binding]; metal-binding site 698761016338 dimer interface [polypeptide binding]; other site 698761016339 Protein of unknown function (DUF992); Region: DUF992; pfam06186 698761016340 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761016341 cyclase homology domain; Region: CHD; cd07302 698761016342 nucleotidyl binding site; other site 698761016343 metal binding site [ion binding]; metal-binding site 698761016344 dimer interface [polypeptide binding]; other site 698761016345 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 698761016346 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 698761016347 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 698761016348 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698761016349 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 698761016350 active sites [active] 698761016351 tetramer interface [polypeptide binding]; other site 698761016352 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761016353 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761016354 Walker A/P-loop; other site 698761016355 ATP binding site [chemical binding]; other site 698761016356 Q-loop/lid; other site 698761016357 ABC transporter signature motif; other site 698761016358 Walker B; other site 698761016359 D-loop; other site 698761016360 H-loop/switch region; other site 698761016361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016362 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761016363 TM-ABC transporter signature motif; other site 698761016364 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761016365 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 698761016366 putative ligand binding site [chemical binding]; other site 698761016367 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761016368 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761016369 nucleotide binding site [chemical binding]; other site 698761016370 AAA domain; Region: AAA_33; pfam13671 698761016371 AAA domain; Region: AAA_17; pfam13207 698761016372 Class I aldolases; Region: Aldolase_Class_I; cl17187 698761016373 catalytic residue [active] 698761016374 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698761016375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 698761016376 DNA binding residues [nucleotide binding] 698761016377 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698761016378 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 698761016379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761016380 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 698761016381 [2Fe-2S] cluster binding site [ion binding]; other site 698761016382 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 698761016383 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 698761016384 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698761016385 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 698761016386 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 698761016387 substrate binding site [chemical binding]; other site 698761016388 catalytic Zn binding site [ion binding]; other site 698761016389 NAD binding site [chemical binding]; other site 698761016390 structural Zn binding site [ion binding]; other site 698761016391 dimer interface [polypeptide binding]; other site 698761016392 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 698761016393 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698761016394 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698761016395 Domain of unknown function DUF21; Region: DUF21; pfam01595 698761016396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698761016397 Transporter associated domain; Region: CorC_HlyC; smart01091 698761016398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761016399 metabolite-proton symporter; Region: 2A0106; TIGR00883 698761016400 putative substrate translocation pore; other site 698761016401 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761016402 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 698761016403 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 698761016404 dimer interface [polypeptide binding]; other site 698761016405 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 698761016406 active site 698761016407 Fe binding site [ion binding]; other site 698761016408 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 698761016409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761016410 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 698761016411 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698761016412 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698761016413 shikimate binding site; other site 698761016414 NAD(P) binding site [chemical binding]; other site 698761016415 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761016416 EamA-like transporter family; Region: EamA; pfam00892 698761016417 PAS fold; Region: PAS_4; pfam08448 698761016418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761016419 putative active site [active] 698761016420 heme pocket [chemical binding]; other site 698761016421 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761016422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761016423 metal binding site [ion binding]; metal-binding site 698761016424 active site 698761016425 I-site; other site 698761016426 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761016427 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 698761016428 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761016429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761016430 DNA-binding site [nucleotide binding]; DNA binding site 698761016431 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698761016432 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 698761016433 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761016434 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761016435 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761016436 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761016437 Walker A/P-loop; other site 698761016438 ATP binding site [chemical binding]; other site 698761016439 Q-loop/lid; other site 698761016440 ABC transporter signature motif; other site 698761016441 Walker B; other site 698761016442 D-loop; other site 698761016443 H-loop/switch region; other site 698761016444 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761016445 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761016446 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016447 TM-ABC transporter signature motif; other site 698761016448 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 698761016449 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761016450 putative ligand binding site [chemical binding]; other site 698761016451 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761016452 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761016453 DNA binding site [nucleotide binding] 698761016454 domain linker motif; other site 698761016455 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 698761016456 putative dimerization interface [polypeptide binding]; other site 698761016457 putative ligand binding site [chemical binding]; other site 698761016458 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698761016459 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698761016460 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698761016461 ATP-binding site [chemical binding]; other site 698761016462 Gluconate-6-phosphate binding site [chemical binding]; other site 698761016463 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 698761016464 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698761016465 NADP binding site [chemical binding]; other site 698761016466 homodimer interface [polypeptide binding]; other site 698761016467 active site 698761016468 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698761016469 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 698761016470 putative ligand binding site [chemical binding]; other site 698761016471 NAD binding site [chemical binding]; other site 698761016472 catalytic site [active] 698761016473 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698761016474 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698761016475 putative NAD(P) binding site [chemical binding]; other site 698761016476 catalytic Zn binding site [ion binding]; other site 698761016477 Domain of unknown function (DUF336); Region: DUF336; cl01249 698761016478 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 698761016479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761016480 dimerization interface [polypeptide binding]; other site 698761016481 putative DNA binding site [nucleotide binding]; other site 698761016482 putative Zn2+ binding site [ion binding]; other site 698761016483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 698761016484 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 698761016485 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 698761016486 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 698761016487 active site 698761016488 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 698761016489 Ligand Binding Site [chemical binding]; other site 698761016490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761016491 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761016492 active site 698761016493 catalytic tetrad [active] 698761016494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761016495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761016496 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 698761016497 putative effector binding pocket; other site 698761016498 putative dimerization interface [polypeptide binding]; other site 698761016499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698761016500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761016501 non-specific DNA binding site [nucleotide binding]; other site 698761016502 salt bridge; other site 698761016503 sequence-specific DNA binding site [nucleotide binding]; other site 698761016504 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 698761016505 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 698761016506 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 698761016507 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 698761016508 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 698761016509 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761016510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761016511 metal binding site [ion binding]; metal-binding site 698761016512 active site 698761016513 I-site; other site 698761016514 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761016515 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 698761016516 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698761016517 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 698761016518 PA14 domain; Region: PA14; pfam07691 698761016519 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 698761016520 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 698761016521 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 698761016522 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 698761016523 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 698761016524 MarR family; Region: MarR_2; pfam12802 698761016525 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761016526 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761016527 nucleotide binding site [chemical binding]; other site 698761016528 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698761016529 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 698761016530 putative active site [active] 698761016531 catalytic site [active] 698761016532 putative metal binding site [ion binding]; other site 698761016533 oligomer interface [polypeptide binding]; other site 698761016534 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698761016535 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 698761016536 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698761016537 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 698761016538 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698761016539 substrate binding site [chemical binding]; other site 698761016540 dimer interface [polypeptide binding]; other site 698761016541 triosephosphate isomerase; Provisional; Region: PRK14565 698761016542 catalytic triad [active] 698761016543 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761016544 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698761016545 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761016546 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698761016547 PCI domain; Region: PCI; cl02111 698761016548 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698761016549 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 698761016550 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 698761016551 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698761016552 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 698761016553 putative N- and C-terminal domain interface [polypeptide binding]; other site 698761016554 putative active site [active] 698761016555 MgATP binding site [chemical binding]; other site 698761016556 catalytic site [active] 698761016557 metal binding site [ion binding]; metal-binding site 698761016558 putative xylulose binding site [chemical binding]; other site 698761016559 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 698761016560 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761016561 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761016562 Walker A/P-loop; other site 698761016563 ATP binding site [chemical binding]; other site 698761016564 Q-loop/lid; other site 698761016565 ABC transporter signature motif; other site 698761016566 Walker B; other site 698761016567 D-loop; other site 698761016568 H-loop/switch region; other site 698761016569 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761016570 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761016571 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016572 TM-ABC transporter signature motif; other site 698761016573 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761016574 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 698761016575 ligand binding site [chemical binding]; other site 698761016576 dimerization interface [polypeptide binding]; other site 698761016577 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761016578 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 698761016579 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761016580 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698761016581 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 698761016582 putative N- and C-terminal domain interface [polypeptide binding]; other site 698761016583 putative active site [active] 698761016584 MgATP binding site [chemical binding]; other site 698761016585 catalytic site [active] 698761016586 metal binding site [ion binding]; metal-binding site 698761016587 putative xylulose binding site [chemical binding]; other site 698761016588 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698761016589 altronate oxidoreductase; Provisional; Region: PRK03643 698761016590 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 698761016591 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698761016592 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698761016593 putative acyl-acceptor binding pocket; other site 698761016594 Cytochrome P450; Region: p450; cl12078 698761016595 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 698761016596 diaminopimelate decarboxylase; Provisional; Region: PRK11165 698761016597 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698761016598 active site 698761016599 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698761016600 substrate binding site [chemical binding]; other site 698761016601 catalytic residues [active] 698761016602 dimer interface [polypeptide binding]; other site 698761016603 hypothetical protein; Provisional; Region: PRK05968 698761016604 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698761016605 homodimer interface [polypeptide binding]; other site 698761016606 substrate-cofactor binding pocket; other site 698761016607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761016608 catalytic residue [active] 698761016609 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 698761016610 putative efflux protein, MATE family; Region: matE; TIGR00797 698761016611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 698761016612 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 698761016613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 698761016614 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698761016615 acyl-activating enzyme (AAE) consensus motif; other site 698761016616 AMP binding site [chemical binding]; other site 698761016617 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698761016618 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698761016619 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 698761016620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761016621 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 698761016622 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698761016623 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 698761016624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761016625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761016626 Coenzyme A binding pocket [chemical binding]; other site 698761016627 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 698761016628 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698761016629 Walker A/P-loop; other site 698761016630 ATP binding site [chemical binding]; other site 698761016631 Q-loop/lid; other site 698761016632 ABC transporter signature motif; other site 698761016633 Walker B; other site 698761016634 D-loop; other site 698761016635 H-loop/switch region; other site 698761016636 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698761016637 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698761016638 siderophore binding site; other site 698761016639 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698761016640 FecCD transport family; Region: FecCD; pfam01032 698761016641 ABC-ATPase subunit interface; other site 698761016642 dimer interface [polypeptide binding]; other site 698761016643 putative PBP binding regions; other site 698761016644 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698761016645 ABC-ATPase subunit interface; other site 698761016646 dimer interface [polypeptide binding]; other site 698761016647 putative PBP binding regions; other site 698761016648 Dienelactone hydrolase family; Region: DLH; pfam01738 698761016649 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 698761016650 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 698761016651 N-terminal plug; other site 698761016652 ligand-binding site [chemical binding]; other site 698761016653 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 698761016654 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 698761016655 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 698761016656 DXD motif; other site 698761016657 PilZ domain; Region: PilZ; pfam07238 698761016658 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 698761016659 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 698761016660 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 698761016661 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 698761016662 Strictosidine synthase; Region: Str_synth; pfam03088 698761016663 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016664 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761016665 TM-ABC transporter signature motif; other site 698761016666 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016667 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761016668 TM-ABC transporter signature motif; other site 698761016669 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761016670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761016671 Walker A/P-loop; other site 698761016672 ATP binding site [chemical binding]; other site 698761016673 Q-loop/lid; other site 698761016674 ABC transporter signature motif; other site 698761016675 Walker B; other site 698761016676 D-loop; other site 698761016677 H-loop/switch region; other site 698761016678 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761016679 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 698761016680 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761016681 putative ligand binding site [chemical binding]; other site 698761016682 GAF domain; Region: GAF; pfam01590 698761016683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698761016684 Histidine kinase; Region: HisKA_3; pfam07730 698761016685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761016686 ATP binding site [chemical binding]; other site 698761016687 Mg2+ binding site [ion binding]; other site 698761016688 G-X-G motif; other site 698761016689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761016690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761016691 active site 698761016692 phosphorylation site [posttranslational modification] 698761016693 intermolecular recognition site; other site 698761016694 dimerization interface [polypeptide binding]; other site 698761016695 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 698761016696 DNA binding residues [nucleotide binding] 698761016697 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 698761016698 galactarate dehydratase; Region: galactar-dH20; TIGR03248 698761016699 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 698761016700 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761016701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761016702 DNA-binding site [nucleotide binding]; DNA binding site 698761016703 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761016704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698761016705 DNA-binding site [nucleotide binding]; DNA binding site 698761016706 FCD domain; Region: FCD; pfam07729 698761016707 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 698761016708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698761016709 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698761016710 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698761016711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 698761016712 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 698761016713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761016714 Transposase; Region: HTH_Tnp_1; pfam01527 698761016715 DDE superfamily endonuclease; Region: DDE_3; pfam13358 698761016716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 698761016717 Homeodomain-like domain; Region: HTH_23; pfam13384 698761016718 Winged helix-turn helix; Region: HTH_29; pfam13551 698761016719 Homeodomain-like domain; Region: HTH_32; pfam13565 698761016720 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761016721 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698761016722 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698761016723 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698761016724 active site 698761016725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761016726 Transposase; Region: HTH_Tnp_1; pfam01527 698761016727 Core-2/I-Branching enzyme; Region: Branch; pfam02485 698761016728 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 698761016729 Methyltransferase domain; Region: Methyltransf_24; pfam13578 698761016730 Integrase core domain; Region: rve; pfam00665 698761016731 Integrase core domain; Region: rve_2; pfam13333 698761016732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761016733 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761016734 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698761016735 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698761016736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761016737 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761016738 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761016739 putative transposase OrfB; Reviewed; Region: PHA02517 698761016740 HTH-like domain; Region: HTH_21; pfam13276 698761016741 Integrase core domain; Region: rve; pfam00665 698761016742 Integrase core domain; Region: rve_3; pfam13683 698761016743 Transposase; Region: HTH_Tnp_1; pfam01527 698761016744 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 698761016745 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 698761016746 DAK2 domain; Region: Dak2; pfam02734 698761016747 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761016748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761016749 Walker A/P-loop; other site 698761016750 ATP binding site [chemical binding]; other site 698761016751 Q-loop/lid; other site 698761016752 ABC transporter signature motif; other site 698761016753 Walker B; other site 698761016754 D-loop; other site 698761016755 H-loop/switch region; other site 698761016756 TOBE domain; Region: TOBE_2; pfam08402 698761016757 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761016758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761016759 Walker A/P-loop; other site 698761016760 ATP binding site [chemical binding]; other site 698761016761 Q-loop/lid; other site 698761016762 ABC transporter signature motif; other site 698761016763 Walker B; other site 698761016764 D-loop; other site 698761016765 H-loop/switch region; other site 698761016766 TOBE domain; Region: TOBE_2; pfam08402 698761016767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761016768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016769 dimer interface [polypeptide binding]; other site 698761016770 conserved gate region; other site 698761016771 putative PBP binding loops; other site 698761016772 ABC-ATPase subunit interface; other site 698761016773 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698761016774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016775 dimer interface [polypeptide binding]; other site 698761016776 conserved gate region; other site 698761016777 putative PBP binding loops; other site 698761016778 ABC-ATPase subunit interface; other site 698761016779 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761016780 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761016781 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761016782 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761016783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761016784 DNA binding site [nucleotide binding] 698761016785 domain linker motif; other site 698761016786 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 698761016787 putative ligand binding site [chemical binding]; other site 698761016788 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761016789 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698761016790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761016791 DNA-binding site [nucleotide binding]; DNA binding site 698761016792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761016793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761016794 homodimer interface [polypeptide binding]; other site 698761016795 catalytic residue [active] 698761016796 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 698761016797 nudix motif; other site 698761016798 EamA-like transporter family; Region: EamA; pfam00892 698761016799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761016800 S-adenosylmethionine binding site [chemical binding]; other site 698761016801 prephenate dehydratase; Provisional; Region: PRK11899 698761016802 Prephenate dehydratase; Region: PDT; pfam00800 698761016803 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698761016804 putative L-Phe binding site [chemical binding]; other site 698761016805 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698761016806 FAD binding domain; Region: FAD_binding_4; pfam01565 698761016807 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 698761016808 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698761016809 phosphate binding site [ion binding]; other site 698761016810 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 698761016811 zinc binding site [ion binding]; other site 698761016812 putative ligand binding site [chemical binding]; other site 698761016813 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 698761016814 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016815 TM-ABC transporter signature motif; other site 698761016816 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 698761016817 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698761016818 Walker A/P-loop; other site 698761016819 ATP binding site [chemical binding]; other site 698761016820 Q-loop/lid; other site 698761016821 ABC transporter signature motif; other site 698761016822 Walker B; other site 698761016823 D-loop; other site 698761016824 H-loop/switch region; other site 698761016825 MarR family; Region: MarR_2; pfam12802 698761016826 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 698761016827 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761016828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761016829 metal binding site [ion binding]; metal-binding site 698761016830 active site 698761016831 I-site; other site 698761016832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 698761016833 SPFH domain / Band 7 family; Region: Band_7; pfam01145 698761016834 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 698761016835 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 698761016836 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 698761016837 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 698761016838 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 698761016839 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 698761016840 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 698761016841 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761016842 classical (c) SDRs; Region: SDR_c; cd05233 698761016843 NAD(P) binding site [chemical binding]; other site 698761016844 active site 698761016845 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698761016846 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761016847 ligand binding site [chemical binding]; other site 698761016848 flexible hinge region; other site 698761016849 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 698761016850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761016851 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761016852 MarR family; Region: MarR; pfam01047 698761016853 MarR family; Region: MarR_2; cl17246 698761016854 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698761016855 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 698761016856 active site 698761016857 catalytic site [active] 698761016858 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761016859 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761016860 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761016861 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698761016862 Walker A/P-loop; other site 698761016863 ATP binding site [chemical binding]; other site 698761016864 Q-loop/lid; other site 698761016865 ABC transporter signature motif; other site 698761016866 Walker B; other site 698761016867 D-loop; other site 698761016868 H-loop/switch region; other site 698761016869 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698761016870 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 698761016871 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 698761016872 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 698761016873 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 698761016874 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 698761016875 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 698761016876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761016877 D-xylulose kinase; Region: XylB; TIGR01312 698761016878 nucleotide binding site [chemical binding]; other site 698761016879 Uncharacterized conserved protein [Function unknown]; Region: COG3347 698761016880 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 698761016881 active site 698761016882 Zn2+ binding site [ion binding]; other site 698761016883 intersubunit interface [polypeptide binding]; other site 698761016884 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761016885 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698761016886 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761016887 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761016888 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698761016889 nucleotide binding site [chemical binding]; other site 698761016890 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761016891 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761016892 Walker A/P-loop; other site 698761016893 ATP binding site [chemical binding]; other site 698761016894 Q-loop/lid; other site 698761016895 ABC transporter signature motif; other site 698761016896 Walker B; other site 698761016897 D-loop; other site 698761016898 H-loop/switch region; other site 698761016899 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761016900 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761016901 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761016902 TM-ABC transporter signature motif; other site 698761016903 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 698761016904 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761016905 putative ligand binding site [chemical binding]; other site 698761016906 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761016907 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698761016908 AP (apurinic/apyrimidinic) site pocket; other site 698761016909 DNA interaction; other site 698761016910 Metal-binding active site; metal-binding site 698761016911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761016912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016913 dimer interface [polypeptide binding]; other site 698761016914 conserved gate region; other site 698761016915 putative PBP binding loops; other site 698761016916 ABC-ATPase subunit interface; other site 698761016917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761016918 dimer interface [polypeptide binding]; other site 698761016919 conserved gate region; other site 698761016920 putative PBP binding loops; other site 698761016921 ABC-ATPase subunit interface; other site 698761016922 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761016923 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761016924 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761016925 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698761016926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761016927 dimerization interface [polypeptide binding]; other site 698761016928 putative Zn2+ binding site [ion binding]; other site 698761016929 putative DNA binding site [nucleotide binding]; other site 698761016930 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761016931 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761016932 nucleotide binding site [chemical binding]; other site 698761016933 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761016934 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761016935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761016936 Walker A/P-loop; other site 698761016937 ATP binding site [chemical binding]; other site 698761016938 Q-loop/lid; other site 698761016939 ABC transporter signature motif; other site 698761016940 Walker B; other site 698761016941 D-loop; other site 698761016942 H-loop/switch region; other site 698761016943 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761016944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761016945 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761016946 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 698761016947 substrate binding pocket [chemical binding]; other site 698761016948 FAD binding site [chemical binding]; other site 698761016949 catalytic base [active] 698761016950 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698761016951 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761016952 NAD(P) binding site [chemical binding]; other site 698761016953 catalytic residues [active] 698761016954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761016955 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 698761016956 NAD(P) binding site [chemical binding]; other site 698761016957 active site 698761016958 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 698761016959 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 698761016960 ligand binding site [chemical binding]; other site 698761016961 NAD binding site [chemical binding]; other site 698761016962 tetramer interface [polypeptide binding]; other site 698761016963 catalytic site [active] 698761016964 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 698761016965 L-serine binding site [chemical binding]; other site 698761016966 ACT domain interface; other site 698761016967 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761016968 classical (c) SDRs; Region: SDR_c; cd05233 698761016969 NAD(P) binding site [chemical binding]; other site 698761016970 active site 698761016971 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698761016972 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761016973 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761016974 dimer interface [polypeptide binding]; other site 698761016975 putative CheW interface [polypeptide binding]; other site 698761016976 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 698761016977 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 698761016978 Sulfate transporter family; Region: Sulfate_transp; pfam00916 698761016979 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 698761016980 active site clefts [active] 698761016981 zinc binding site [ion binding]; other site 698761016982 dimer interface [polypeptide binding]; other site 698761016983 Creatinine amidohydrolase; Region: Creatininase; pfam02633 698761016984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761016985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761016986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761016987 dimerization interface [polypeptide binding]; other site 698761016988 NMT1/THI5 like; Region: NMT1; pfam09084 698761016989 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698761016990 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761016991 Walker A/P-loop; other site 698761016992 ATP binding site [chemical binding]; other site 698761016993 Q-loop/lid; other site 698761016994 ABC transporter signature motif; other site 698761016995 Walker B; other site 698761016996 D-loop; other site 698761016997 H-loop/switch region; other site 698761016998 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761016999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017000 dimer interface [polypeptide binding]; other site 698761017001 conserved gate region; other site 698761017002 putative PBP binding loops; other site 698761017003 ABC-ATPase subunit interface; other site 698761017004 cytosine deaminase-like protein; Validated; Region: PRK07583 698761017005 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 698761017006 active site 698761017007 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698761017008 FAD binding domain; Region: FAD_binding_4; pfam01565 698761017009 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 698761017010 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761017011 BON domain; Region: BON; pfam04972 698761017012 Predicted membrane protein [Function unknown]; Region: COG1238 698761017013 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 698761017014 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698761017015 Walker A/P-loop; other site 698761017016 ATP binding site [chemical binding]; other site 698761017017 Q-loop/lid; other site 698761017018 ABC transporter signature motif; other site 698761017019 Walker B; other site 698761017020 D-loop; other site 698761017021 H-loop/switch region; other site 698761017022 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 698761017023 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698761017024 Walker A/P-loop; other site 698761017025 ATP binding site [chemical binding]; other site 698761017026 Q-loop/lid; other site 698761017027 ABC transporter signature motif; other site 698761017028 Walker B; other site 698761017029 D-loop; other site 698761017030 H-loop/switch region; other site 698761017031 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698761017032 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698761017033 TM-ABC transporter signature motif; other site 698761017034 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698761017035 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761017036 TM-ABC transporter signature motif; other site 698761017037 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 698761017038 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 698761017039 putative ligand binding site [chemical binding]; other site 698761017040 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 698761017041 Na binding site [ion binding]; other site 698761017042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761017043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761017044 dimer interface [polypeptide binding]; other site 698761017045 phosphorylation site [posttranslational modification] 698761017046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761017047 ATP binding site [chemical binding]; other site 698761017048 Mg2+ binding site [ion binding]; other site 698761017049 G-X-G motif; other site 698761017050 Response regulator receiver domain; Region: Response_reg; pfam00072 698761017051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761017052 active site 698761017053 phosphorylation site [posttranslational modification] 698761017054 intermolecular recognition site; other site 698761017055 dimerization interface [polypeptide binding]; other site 698761017056 Response regulator receiver domain; Region: Response_reg; pfam00072 698761017057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761017058 active site 698761017059 phosphorylation site [posttranslational modification] 698761017060 intermolecular recognition site; other site 698761017061 dimerization interface [polypeptide binding]; other site 698761017062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761017063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761017064 DNA binding residues [nucleotide binding] 698761017065 dimerization interface [polypeptide binding]; other site 698761017066 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761017067 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 698761017068 benzoate transport; Region: 2A0115; TIGR00895 698761017069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761017070 putative substrate translocation pore; other site 698761017071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761017072 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698761017073 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698761017074 inhibitor site; inhibition site 698761017075 active site 698761017076 dimer interface [polypeptide binding]; other site 698761017077 catalytic residue [active] 698761017078 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761017079 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761017080 DNA binding site [nucleotide binding] 698761017081 domain linker motif; other site 698761017082 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698761017083 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761017084 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 698761017085 active site 698761017086 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698761017087 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698761017088 active site 698761017089 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761017090 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761017091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761017092 Walker A/P-loop; other site 698761017093 ATP binding site [chemical binding]; other site 698761017094 Q-loop/lid; other site 698761017095 ABC transporter signature motif; other site 698761017096 Walker B; other site 698761017097 D-loop; other site 698761017098 H-loop/switch region; other site 698761017099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698761017100 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698761017101 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698761017102 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761017103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761017104 NAD(P) binding site [chemical binding]; other site 698761017105 active site 698761017106 triosephosphate isomerase; Provisional; Region: PRK14565 698761017107 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698761017108 substrate binding site [chemical binding]; other site 698761017109 dimer interface [polypeptide binding]; other site 698761017110 catalytic triad [active] 698761017111 short chain dehydrogenase; Provisional; Region: PRK06114 698761017112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761017113 NAD(P) binding site [chemical binding]; other site 698761017114 active site 698761017115 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761017116 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761017117 Walker A/P-loop; other site 698761017118 ATP binding site [chemical binding]; other site 698761017119 Q-loop/lid; other site 698761017120 ABC transporter signature motif; other site 698761017121 Walker B; other site 698761017122 D-loop; other site 698761017123 H-loop/switch region; other site 698761017124 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761017125 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761017126 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698761017127 ligand binding site [chemical binding]; other site 698761017128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761017129 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761017130 TM-ABC transporter signature motif; other site 698761017131 transketolase; Reviewed; Region: PRK05899 698761017132 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698761017133 TPP-binding site [chemical binding]; other site 698761017134 dimer interface [polypeptide binding]; other site 698761017135 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 698761017136 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698761017137 PYR/PP interface [polypeptide binding]; other site 698761017138 dimer interface [polypeptide binding]; other site 698761017139 TPP binding site [chemical binding]; other site 698761017140 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698761017141 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 698761017142 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 698761017143 N- and C-terminal domain interface [polypeptide binding]; other site 698761017144 active site 698761017145 MgATP binding site [chemical binding]; other site 698761017146 catalytic site [active] 698761017147 metal binding site [ion binding]; metal-binding site 698761017148 putative homotetramer interface [polypeptide binding]; other site 698761017149 putative homodimer interface [polypeptide binding]; other site 698761017150 glycerol binding site [chemical binding]; other site 698761017151 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698761017152 MarR family; Region: MarR_2; pfam12802 698761017153 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698761017154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761017155 H-loop/switch region; other site 698761017156 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 698761017157 NmrA-like family; Region: NmrA; pfam05368 698761017158 NAD(P) binding site [chemical binding]; other site 698761017159 active site lysine 698761017160 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698761017161 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 698761017162 YceI-like domain; Region: YceI; smart00867 698761017163 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698761017164 Integrase core domain; Region: rve; pfam00665 698761017165 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761017166 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761017167 substrate binding pocket [chemical binding]; other site 698761017168 membrane-bound complex binding site; other site 698761017169 hinge residues; other site 698761017170 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 698761017171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017172 ABC-ATPase subunit interface; other site 698761017173 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761017174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017175 dimer interface [polypeptide binding]; other site 698761017176 conserved gate region; other site 698761017177 putative PBP binding loops; other site 698761017178 ABC-ATPase subunit interface; other site 698761017179 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761017180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761017181 Walker A/P-loop; other site 698761017182 ATP binding site [chemical binding]; other site 698761017183 Q-loop/lid; other site 698761017184 ABC transporter signature motif; other site 698761017185 Walker B; other site 698761017186 D-loop; other site 698761017187 H-loop/switch region; other site 698761017188 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 698761017189 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698761017190 Bacterial transcriptional regulator; Region: IclR; pfam01614 698761017191 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 698761017192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761017193 inhibitor-cofactor binding pocket; inhibition site 698761017194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761017195 catalytic residue [active] 698761017196 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 698761017197 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698761017198 active site 698761017199 ATP binding site [chemical binding]; other site 698761017200 substrate binding site [chemical binding]; other site 698761017201 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761017202 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698761017203 tetramerization interface [polypeptide binding]; other site 698761017204 NAD(P) binding site [chemical binding]; other site 698761017205 catalytic residues [active] 698761017206 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 698761017207 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 698761017208 aminotransferase; Provisional; Region: PRK06105 698761017209 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761017210 inhibitor-cofactor binding pocket; inhibition site 698761017211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761017212 catalytic residue [active] 698761017213 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698761017214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761017215 substrate binding pocket [chemical binding]; other site 698761017216 membrane-bound complex binding site; other site 698761017217 hinge residues; other site 698761017218 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 698761017219 agmatinase; Region: agmatinase; TIGR01230 698761017220 oligomer interface [polypeptide binding]; other site 698761017221 putative active site [active] 698761017222 Mn binding site [ion binding]; other site 698761017223 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761017224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761017225 DNA-binding site [nucleotide binding]; DNA binding site 698761017226 FCD domain; Region: FCD; pfam07729 698761017227 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761017228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017229 dimer interface [polypeptide binding]; other site 698761017230 conserved gate region; other site 698761017231 putative PBP binding loops; other site 698761017232 ABC-ATPase subunit interface; other site 698761017233 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761017234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017235 dimer interface [polypeptide binding]; other site 698761017236 conserved gate region; other site 698761017237 putative PBP binding loops; other site 698761017238 ABC-ATPase subunit interface; other site 698761017239 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 698761017240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761017241 Walker A/P-loop; other site 698761017242 ATP binding site [chemical binding]; other site 698761017243 Q-loop/lid; other site 698761017244 ABC transporter signature motif; other site 698761017245 Walker B; other site 698761017246 D-loop; other site 698761017247 H-loop/switch region; other site 698761017248 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 698761017249 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 698761017250 active site 698761017251 dimer interface [polypeptide binding]; other site 698761017252 non-prolyl cis peptide bond; other site 698761017253 insertion regions; other site 698761017254 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761017255 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698761017256 Walker A/P-loop; other site 698761017257 ATP binding site [chemical binding]; other site 698761017258 Q-loop/lid; other site 698761017259 ABC transporter signature motif; other site 698761017260 Walker B; other site 698761017261 D-loop; other site 698761017262 H-loop/switch region; other site 698761017263 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698761017264 TM-ABC transporter signature motif; other site 698761017265 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698761017266 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698761017267 TM-ABC transporter signature motif; other site 698761017268 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 698761017269 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 698761017270 putative ligand binding site [chemical binding]; other site 698761017271 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698761017272 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698761017273 Walker A/P-loop; other site 698761017274 ATP binding site [chemical binding]; other site 698761017275 Q-loop/lid; other site 698761017276 ABC transporter signature motif; other site 698761017277 Walker B; other site 698761017278 D-loop; other site 698761017279 H-loop/switch region; other site 698761017280 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761017281 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 698761017282 Flavin binding site [chemical binding]; other site 698761017283 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761017284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761017285 DNA-binding site [nucleotide binding]; DNA binding site 698761017286 FCD domain; Region: FCD; pfam07729 698761017287 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 698761017288 zinc binding site [ion binding]; other site 698761017289 putative ligand binding site [chemical binding]; other site 698761017290 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 698761017291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761017292 Walker A/P-loop; other site 698761017293 ATP binding site [chemical binding]; other site 698761017294 Q-loop/lid; other site 698761017295 ABC transporter signature motif; other site 698761017296 Walker B; other site 698761017297 D-loop; other site 698761017298 H-loop/switch region; other site 698761017299 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761017300 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 698761017301 TM-ABC transporter signature motif; other site 698761017302 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 698761017303 kynureninase; Region: kynureninase; TIGR01814 698761017304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761017305 catalytic residue [active] 698761017306 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698761017307 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 698761017308 putative dimer interface [polypeptide binding]; other site 698761017309 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761017310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761017311 PAS domain; Region: PAS_9; pfam13426 698761017312 putative active site [active] 698761017313 heme pocket [chemical binding]; other site 698761017314 PAS fold; Region: PAS_4; pfam08448 698761017315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761017316 putative active site [active] 698761017317 heme pocket [chemical binding]; other site 698761017318 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761017319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761017320 metal binding site [ion binding]; metal-binding site 698761017321 active site 698761017322 I-site; other site 698761017323 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761017324 mannonate dehydratase; Provisional; Region: PRK03906 698761017325 mannonate dehydratase; Region: uxuA; TIGR00695 698761017326 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761017327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761017328 DNA-binding site [nucleotide binding]; DNA binding site 698761017329 FCD domain; Region: FCD; pfam07729 698761017330 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 698761017331 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698761017332 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 698761017333 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 698761017334 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 698761017335 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698761017336 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761017337 protein binding site [polypeptide binding]; other site 698761017338 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698761017339 protein binding site [polypeptide binding]; other site 698761017340 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698761017341 HSP70 interaction site [polypeptide binding]; other site 698761017342 colanic acid exporter; Provisional; Region: PRK10459 698761017343 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 698761017344 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698761017345 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698761017346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761017347 DNA-binding site [nucleotide binding]; DNA binding site 698761017348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761017349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761017350 homodimer interface [polypeptide binding]; other site 698761017351 catalytic residue [active] 698761017352 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 698761017353 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761017354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761017355 substrate binding pocket [chemical binding]; other site 698761017356 membrane-bound complex binding site; other site 698761017357 hinge residues; other site 698761017358 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761017359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017360 dimer interface [polypeptide binding]; other site 698761017361 conserved gate region; other site 698761017362 putative PBP binding loops; other site 698761017363 ABC-ATPase subunit interface; other site 698761017364 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761017365 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761017366 Walker A/P-loop; other site 698761017367 ATP binding site [chemical binding]; other site 698761017368 Q-loop/lid; other site 698761017369 ABC transporter signature motif; other site 698761017370 Walker B; other site 698761017371 D-loop; other site 698761017372 H-loop/switch region; other site 698761017373 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761017374 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698761017375 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 698761017376 metal binding site [ion binding]; metal-binding site 698761017377 putative dimer interface [polypeptide binding]; other site 698761017378 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698761017379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761017380 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698761017381 dimerization interface [polypeptide binding]; other site 698761017382 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 698761017383 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 698761017384 dimer interface [polypeptide binding]; other site 698761017385 active site 698761017386 heme binding site [chemical binding]; other site 698761017387 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 698761017388 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761017389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761017390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761017391 active site 698761017392 catalytic tetrad [active] 698761017393 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698761017394 PhnA protein; Region: PhnA; pfam03831 698761017395 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 698761017396 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761017397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761017398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761017399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 698761017400 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 698761017401 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761017402 NAD(P) binding site [chemical binding]; other site 698761017403 catalytic residues [active] 698761017404 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 698761017405 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 698761017406 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 698761017407 active site 698761017408 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698761017409 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 698761017410 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 698761017411 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 698761017412 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698761017413 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761017414 Beta-lactamase; Region: Beta-lactamase; pfam00144 698761017415 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698761017416 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 698761017417 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761017418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761017419 active site 698761017420 phosphorylation site [posttranslational modification] 698761017421 intermolecular recognition site; other site 698761017422 dimerization interface [polypeptide binding]; other site 698761017423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761017424 DNA binding site [nucleotide binding] 698761017425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761017426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761017427 dimer interface [polypeptide binding]; other site 698761017428 phosphorylation site [posttranslational modification] 698761017429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761017430 ATP binding site [chemical binding]; other site 698761017431 Mg2+ binding site [ion binding]; other site 698761017432 G-X-G motif; other site 698761017433 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 698761017434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761017435 putative substrate translocation pore; other site 698761017436 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698761017437 putative acyl-acceptor binding pocket; other site 698761017438 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 698761017439 acyl-activating enzyme (AAE) consensus motif; other site 698761017440 putative AMP binding site [chemical binding]; other site 698761017441 yiaA/B two helix domain; Region: YiaAB; cl01759 698761017442 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698761017443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761017444 WHG domain; Region: WHG; pfam13305 698761017445 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698761017446 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698761017447 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 698761017448 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 698761017449 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 698761017450 Switch I; other site 698761017451 Switch II; other site 698761017452 septum formation inhibitor; Reviewed; Region: minC; PRK05177 698761017453 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 698761017454 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 698761017455 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 698761017456 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698761017457 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 698761017458 dimer interface [polypeptide binding]; other site 698761017459 phosphorylation site [posttranslational modification] 698761017460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761017461 ATP binding site [chemical binding]; other site 698761017462 Mg2+ binding site [ion binding]; other site 698761017463 G-X-G motif; other site 698761017464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761017465 osmolarity response regulator; Provisional; Region: ompR; PRK09468 698761017466 active site 698761017467 phosphorylation site [posttranslational modification] 698761017468 intermolecular recognition site; other site 698761017469 dimerization interface [polypeptide binding]; other site 698761017470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761017471 DNA binding site [nucleotide binding] 698761017472 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761017473 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 698761017474 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698761017475 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698761017476 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698761017477 catalytic residues [active] 698761017478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761017479 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698761017480 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 698761017481 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 698761017482 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761017483 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 698761017484 active sites [active] 698761017485 tetramer interface [polypeptide binding]; other site 698761017486 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 698761017487 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761017488 Walker A/P-loop; other site 698761017489 ATP binding site [chemical binding]; other site 698761017490 Q-loop/lid; other site 698761017491 ABC transporter signature motif; other site 698761017492 Walker B; other site 698761017493 D-loop; other site 698761017494 H-loop/switch region; other site 698761017495 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761017496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017497 dimer interface [polypeptide binding]; other site 698761017498 conserved gate region; other site 698761017499 putative PBP binding loops; other site 698761017500 ABC-ATPase subunit interface; other site 698761017501 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761017502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017503 dimer interface [polypeptide binding]; other site 698761017504 conserved gate region; other site 698761017505 putative PBP binding loops; other site 698761017506 ABC-ATPase subunit interface; other site 698761017507 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 698761017508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761017509 substrate binding pocket [chemical binding]; other site 698761017510 membrane-bound complex binding site; other site 698761017511 hinge residues; other site 698761017512 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 698761017513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761017514 DNA-binding site [nucleotide binding]; DNA binding site 698761017515 UTRA domain; Region: UTRA; pfam07702 698761017516 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761017517 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 698761017518 AsnC family; Region: AsnC_trans_reg; pfam01037 698761017519 ornithine cyclodeaminase; Validated; Region: PRK07589 698761017520 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698761017521 PAS fold; Region: PAS_4; pfam08448 698761017522 PAS domain S-box; Region: sensory_box; TIGR00229 698761017523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761017524 putative active site [active] 698761017525 heme pocket [chemical binding]; other site 698761017526 PAS domain S-box; Region: sensory_box; TIGR00229 698761017527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761017528 putative active site [active] 698761017529 heme pocket [chemical binding]; other site 698761017530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698761017531 HWE histidine kinase; Region: HWE_HK; smart00911 698761017532 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698761017533 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761017534 putative DNA binding site [nucleotide binding]; other site 698761017535 AsnC family; Region: AsnC_trans_reg; pfam01037 698761017536 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698761017537 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 698761017538 active site 698761017539 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698761017540 dimer interface [polypeptide binding]; other site 698761017541 substrate binding site [chemical binding]; other site 698761017542 catalytic residues [active] 698761017543 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 698761017544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761017545 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698761017546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761017547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761017548 putative substrate translocation pore; other site 698761017549 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761017550 Helix-turn-helix domain; Region: HTH_18; pfam12833 698761017551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761017552 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 698761017553 active site 698761017554 SAM binding site [chemical binding]; other site 698761017555 homodimer interface [polypeptide binding]; other site 698761017556 precorrin-3B synthase; Region: CobG; TIGR02435 698761017557 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698761017558 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698761017559 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 698761017560 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 698761017561 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 698761017562 active site 698761017563 SAM binding site [chemical binding]; other site 698761017564 homodimer interface [polypeptide binding]; other site 698761017565 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 698761017566 active site 698761017567 SAM binding site [chemical binding]; other site 698761017568 homodimer interface [polypeptide binding]; other site 698761017569 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 698761017570 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 698761017571 active site 698761017572 putative homodimer interface [polypeptide binding]; other site 698761017573 SAM binding site [chemical binding]; other site 698761017574 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 698761017575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761017576 S-adenosylmethionine binding site [chemical binding]; other site 698761017577 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 698761017578 active site 698761017579 SAM binding site [chemical binding]; other site 698761017580 homodimer interface [polypeptide binding]; other site 698761017581 nickel responsive regulator; Provisional; Region: PRK02967 698761017582 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 698761017583 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 698761017584 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 698761017585 DNA interaction; other site 698761017586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 698761017587 Integrase core domain; Region: rve; pfam00665 698761017588 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 698761017589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698761017590 Walker A motif; other site 698761017591 ATP binding site [chemical binding]; other site 698761017592 Walker B motif; other site 698761017593 arginine finger; other site 698761017594 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698761017595 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 698761017596 putative di-iron ligands [ion binding]; other site 698761017597 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 698761017598 [2Fe-2S] cluster binding site [ion binding]; other site 698761017599 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 698761017600 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698761017601 Predicted flavoprotein [General function prediction only]; Region: COG0431 698761017602 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698761017603 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698761017604 EamA-like transporter family; Region: EamA; pfam00892 698761017605 EamA-like transporter family; Region: EamA; pfam00892 698761017606 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 698761017607 Chain length determinant protein; Region: Wzz; pfam02706 698761017608 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 698761017609 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698761017610 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698761017611 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 698761017612 active site 698761017613 tetramer interface; other site 698761017614 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 698761017615 active site 698761017616 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698761017617 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 698761017618 active site 698761017619 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698761017620 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698761017621 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 698761017622 Ligand binding site; other site 698761017623 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 698761017624 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 698761017625 active site 698761017626 active site 698761017627 catalytic residues [active] 698761017628 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698761017629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698761017630 active site 698761017631 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 698761017632 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698761017633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698761017634 active site 698761017635 Exopolysaccharide production repressor; Region: SyrA; pfam11089 698761017636 Bacterial sugar transferase; Region: Bac_transf; pfam02397 698761017637 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 698761017638 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 698761017639 SLBB domain; Region: SLBB; pfam10531 698761017640 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 698761017641 O-Antigen ligase; Region: Wzy_C; pfam04932 698761017642 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761017643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761017644 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761017645 TM-ABC transporter signature motif; other site 698761017646 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761017647 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761017648 Walker A/P-loop; other site 698761017649 ATP binding site [chemical binding]; other site 698761017650 Q-loop/lid; other site 698761017651 ABC transporter signature motif; other site 698761017652 Walker B; other site 698761017653 D-loop; other site 698761017654 H-loop/switch region; other site 698761017655 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761017656 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 698761017657 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761017658 putative ligand binding site [chemical binding]; other site 698761017659 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761017660 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761017661 active site 698761017662 catalytic tetrad [active] 698761017663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761017664 DNA-binding site [nucleotide binding]; DNA binding site 698761017665 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761017666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698761017667 DNA-binding site [nucleotide binding]; DNA binding site 698761017668 FCD domain; Region: FCD; pfam07729 698761017669 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 698761017670 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 698761017671 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 698761017672 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 698761017673 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761017674 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761017675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761017676 alpha-galactosidase; Provisional; Region: PRK15076 698761017677 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 698761017678 NAD binding site [chemical binding]; other site 698761017679 sugar binding site [chemical binding]; other site 698761017680 divalent metal binding site [ion binding]; other site 698761017681 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 698761017682 dimer interface [polypeptide binding]; other site 698761017683 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 698761017684 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698761017685 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761017686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017687 dimer interface [polypeptide binding]; other site 698761017688 conserved gate region; other site 698761017689 putative PBP binding loops; other site 698761017690 ABC-ATPase subunit interface; other site 698761017691 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 698761017692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761017693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017694 dimer interface [polypeptide binding]; other site 698761017695 conserved gate region; other site 698761017696 putative PBP binding loops; other site 698761017697 ABC-ATPase subunit interface; other site 698761017698 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 698761017699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761017700 Walker A/P-loop; other site 698761017701 ATP binding site [chemical binding]; other site 698761017702 Q-loop/lid; other site 698761017703 ABC transporter signature motif; other site 698761017704 Walker B; other site 698761017705 D-loop; other site 698761017706 H-loop/switch region; other site 698761017707 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761017708 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761017709 Walker A/P-loop; other site 698761017710 ATP binding site [chemical binding]; other site 698761017711 Q-loop/lid; other site 698761017712 ABC transporter signature motif; other site 698761017713 Walker B; other site 698761017714 D-loop; other site 698761017715 H-loop/switch region; other site 698761017716 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761017717 alpha-galactosidase; Provisional; Region: PRK15076 698761017718 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 698761017719 NAD binding site [chemical binding]; other site 698761017720 sugar binding site [chemical binding]; other site 698761017721 divalent metal binding site [ion binding]; other site 698761017722 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 698761017723 dimer interface [polypeptide binding]; other site 698761017724 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 698761017725 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698761017726 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698761017727 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698761017728 ligand binding site [chemical binding]; other site 698761017729 flexible hinge region; other site 698761017730 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761017731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761017732 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 698761017733 Walker A/P-loop; other site 698761017734 ATP binding site [chemical binding]; other site 698761017735 Q-loop/lid; other site 698761017736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761017737 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698761017738 ABC transporter signature motif; other site 698761017739 Walker B; other site 698761017740 D-loop; other site 698761017741 H-loop/switch region; other site 698761017742 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 698761017743 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 698761017744 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 698761017745 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 698761017746 putative ADP-binding pocket [chemical binding]; other site 698761017747 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 698761017748 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 698761017749 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761017750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017751 dimer interface [polypeptide binding]; other site 698761017752 conserved gate region; other site 698761017753 putative PBP binding loops; other site 698761017754 ABC-ATPase subunit interface; other site 698761017755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761017756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761017757 dimer interface [polypeptide binding]; other site 698761017758 conserved gate region; other site 698761017759 putative PBP binding loops; other site 698761017760 ABC-ATPase subunit interface; other site 698761017761 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 698761017762 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698761017763 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761017764 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761017765 Walker A/P-loop; other site 698761017766 ATP binding site [chemical binding]; other site 698761017767 Q-loop/lid; other site 698761017768 ABC transporter signature motif; other site 698761017769 Walker B; other site 698761017770 D-loop; other site 698761017771 H-loop/switch region; other site 698761017772 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761017773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761017774 Walker A/P-loop; other site 698761017775 ATP binding site [chemical binding]; other site 698761017776 Q-loop/lid; other site 698761017777 ABC transporter signature motif; other site 698761017778 Walker B; other site 698761017779 D-loop; other site 698761017780 H-loop/switch region; other site 698761017781 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761017782 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761017783 cyclase homology domain; Region: CHD; cd07302 698761017784 nucleotidyl binding site; other site 698761017785 metal binding site [ion binding]; metal-binding site 698761017786 dimer interface [polypeptide binding]; other site 698761017787 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 698761017788 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 698761017789 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 698761017790 Succinate dehydrogenase/Fumarate reductase transmembrane subunit; Region: Sdh_cyt; pfam01127 698761017791 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 698761017792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761017793 catalytic loop [active] 698761017794 iron binding site [ion binding]; other site 698761017795 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761017796 cyclase homology domain; Region: CHD; cd07302 698761017797 nucleotidyl binding site; other site 698761017798 metal binding site [ion binding]; metal-binding site 698761017799 dimer interface [polypeptide binding]; other site 698761017800 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698761017801 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698761017802 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 698761017803 NodB motif; other site 698761017804 putative active site [active] 698761017805 putative catalytic site [active] 698761017806 putative Zn binding site [ion binding]; other site 698761017807 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 698761017808 putative dimer interface [polypeptide binding]; other site 698761017809 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761017810 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 698761017811 MarR family; Region: MarR_2; cl17246 698761017812 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761017813 5-oxoprolinase; Region: PLN02666 698761017814 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 698761017815 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 698761017816 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 698761017817 Uncharacterized conserved protein [Function unknown]; Region: COG3791 698761017818 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 698761017819 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 698761017820 Walker A/P-loop; other site 698761017821 ATP binding site [chemical binding]; other site 698761017822 Q-loop/lid; other site 698761017823 ABC transporter signature motif; other site 698761017824 Walker B; other site 698761017825 D-loop; other site 698761017826 H-loop/switch region; other site 698761017827 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 698761017828 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 698761017829 Walker A/P-loop; other site 698761017830 ATP binding site [chemical binding]; other site 698761017831 Q-loop/lid; other site 698761017832 ABC transporter signature motif; other site 698761017833 Walker B; other site 698761017834 D-loop; other site 698761017835 H-loop/switch region; other site 698761017836 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 698761017837 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 698761017838 TM-ABC transporter signature motif; other site 698761017839 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761017840 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 698761017841 TM-ABC transporter signature motif; other site 698761017842 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 698761017843 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698761017844 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 698761017845 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 698761017846 tetramer interface [polypeptide binding]; other site 698761017847 active site 698761017848 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 698761017849 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 698761017850 heterodimer interface [polypeptide binding]; other site 698761017851 active site 698761017852 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 698761017853 heterodimer interface [polypeptide binding]; other site 698761017854 multimer interface [polypeptide binding]; other site 698761017855 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 698761017856 active site 698761017857 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 698761017858 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 698761017859 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 698761017860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761017861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761017862 dimerization interface [polypeptide binding]; other site 698761017863 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 698761017864 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698761017865 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 698761017866 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761017867 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 698761017868 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 698761017869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761017870 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 698761017871 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 698761017872 Bacterial transcriptional regulator; Region: IclR; pfam01614 698761017873 Coenzyme A transferase; Region: CoA_trans; cl17247 698761017874 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 698761017875 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 698761017876 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698761017877 dimer interface [polypeptide binding]; other site 698761017878 active site 698761017879 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698761017880 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698761017881 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698761017882 Ligand Binding Site [chemical binding]; other site 698761017883 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 698761017884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761017885 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 698761017886 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 698761017887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761017888 metal binding site [ion binding]; metal-binding site 698761017889 active site 698761017890 I-site; other site 698761017891 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761017892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761017893 S-adenosylmethionine binding site [chemical binding]; other site 698761017894 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698761017895 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698761017896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761017897 S-adenosylmethionine binding site [chemical binding]; other site 698761017898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698761017899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761017900 dimer interface [polypeptide binding]; other site 698761017901 phosphorylation site [posttranslational modification] 698761017902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761017903 ATP binding site [chemical binding]; other site 698761017904 Mg2+ binding site [ion binding]; other site 698761017905 G-X-G motif; other site 698761017906 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761017907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761017908 active site 698761017909 phosphorylation site [posttranslational modification] 698761017910 intermolecular recognition site; other site 698761017911 dimerization interface [polypeptide binding]; other site 698761017912 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761017913 DNA binding site [nucleotide binding] 698761017914 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698761017915 B12 binding site [chemical binding]; other site 698761017916 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 698761017917 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 698761017918 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 698761017919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761017920 putative substrate translocation pore; other site 698761017921 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761017922 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761017923 Walker A/P-loop; other site 698761017924 ATP binding site [chemical binding]; other site 698761017925 Q-loop/lid; other site 698761017926 ABC transporter signature motif; other site 698761017927 Walker B; other site 698761017928 D-loop; other site 698761017929 H-loop/switch region; other site 698761017930 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761017931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761017932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761017933 TM-ABC transporter signature motif; other site 698761017934 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 698761017935 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698761017936 putative ligand binding site [chemical binding]; other site 698761017937 Uncharacterized conserved protein [Function unknown]; Region: COG5276 698761017938 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761017939 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761017940 active site 698761017941 catalytic tetrad [active] 698761017942 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698761017943 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698761017944 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761017945 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 698761017946 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 698761017947 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698761017948 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761017949 catalytic loop [active] 698761017950 iron binding site [ion binding]; other site 698761017951 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698761017952 NIPSNAP; Region: NIPSNAP; pfam07978 698761017953 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 698761017954 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 698761017955 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698761017956 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698761017957 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698761017958 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761017959 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698761017960 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761017961 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761017962 Cytochrome c; Region: Cytochrom_C; pfam00034 698761017963 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698761017964 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698761017965 Cytochrome c; Region: Cytochrom_C; pfam00034 698761017966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761017967 putative transporter; Provisional; Region: PRK12382 698761017968 putative substrate translocation pore; other site 698761017969 Putative ParB-like nuclease; Region: ParBc_2; cl17538 698761017970 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 698761017971 active site 698761017972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698761017973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761017974 active site 698761017975 phosphorylation site [posttranslational modification] 698761017976 intermolecular recognition site; other site 698761017977 dimerization interface [polypeptide binding]; other site 698761017978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698761017979 DNA binding site [nucleotide binding] 698761017980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761017981 dimerization interface [polypeptide binding]; other site 698761017982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698761017983 dimer interface [polypeptide binding]; other site 698761017984 phosphorylation site [posttranslational modification] 698761017985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698761017986 ATP binding site [chemical binding]; other site 698761017987 Mg2+ binding site [ion binding]; other site 698761017988 G-X-G motif; other site 698761017989 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 698761017990 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 698761017991 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 698761017992 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698761017993 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 698761017994 active site 698761017995 nucleophile elbow; other site 698761017996 Patatin phospholipase; Region: DUF3734; pfam12536 698761017997 acetoacetate decarboxylase; Provisional; Region: PRK02265 698761017998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761017999 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 698761018000 NAD(P) binding site [chemical binding]; other site 698761018001 active site 698761018002 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 698761018003 Methyltransferase domain; Region: Methyltransf_24; pfam13578 698761018004 Integrase core domain; Region: rve; pfam00665 698761018005 Integrase core domain; Region: rve_2; pfam13333 698761018006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 698761018007 Helix-turn-helix domain; Region: HTH_28; pfam13518 698761018008 methionine gamma-lyase; Validated; Region: PRK07049 698761018009 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698761018010 homodimer interface [polypeptide binding]; other site 698761018011 substrate-cofactor binding pocket; other site 698761018012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761018013 catalytic residue [active] 698761018014 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761018015 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761018016 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761018017 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761018018 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761018019 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 698761018020 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698761018021 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761018022 Walker A/P-loop; other site 698761018023 ATP binding site [chemical binding]; other site 698761018024 Q-loop/lid; other site 698761018025 ABC transporter signature motif; other site 698761018026 Walker B; other site 698761018027 D-loop; other site 698761018028 H-loop/switch region; other site 698761018029 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 698761018030 dimer interface [polypeptide binding]; other site 698761018031 Alkaline phosphatase homologues; Region: alkPPc; smart00098 698761018032 active site 698761018033 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 698761018034 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761018035 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698761018036 AsnC family; Region: AsnC_trans_reg; pfam01037 698761018037 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698761018038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761018039 S-adenosylmethionine binding site [chemical binding]; other site 698761018040 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 698761018041 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 698761018042 UTRA domain; Region: UTRA; cl17743 698761018043 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 698761018044 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 698761018045 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 698761018046 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 698761018047 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 698761018048 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698761018049 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 698761018050 Cl binding site [ion binding]; other site 698761018051 oligomer interface [polypeptide binding]; other site 698761018052 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 698761018053 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 698761018054 Curlin associated repeat; Region: Curlin_rpt; pfam07012 698761018055 short chain dehydrogenase; Provisional; Region: PRK06500 698761018056 classical (c) SDRs; Region: SDR_c; cd05233 698761018057 NAD(P) binding site [chemical binding]; other site 698761018058 active site 698761018059 LysR family transcriptional regulator; Provisional; Region: PRK14997 698761018060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761018061 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 698761018062 putative effector binding pocket; other site 698761018063 putative dimerization interface [polypeptide binding]; other site 698761018064 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 698761018065 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 698761018066 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 698761018067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018068 dimer interface [polypeptide binding]; other site 698761018069 conserved gate region; other site 698761018070 putative PBP binding loops; other site 698761018071 ABC-ATPase subunit interface; other site 698761018072 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 698761018073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698761018074 Walker A/P-loop; other site 698761018075 ATP binding site [chemical binding]; other site 698761018076 Q-loop/lid; other site 698761018077 ABC transporter signature motif; other site 698761018078 Walker B; other site 698761018079 D-loop; other site 698761018080 H-loop/switch region; other site 698761018081 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 698761018082 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 698761018083 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 698761018084 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 698761018085 urea carboxylase; Region: urea_carbox; TIGR02712 698761018086 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698761018087 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698761018088 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 698761018089 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 698761018090 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 698761018091 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698761018092 carboxyltransferase (CT) interaction site; other site 698761018093 biotinylation site [posttranslational modification]; other site 698761018094 allophanate hydrolase; Provisional; Region: PRK08186 698761018095 Amidase; Region: Amidase; cl11426 698761018096 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761018097 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761018098 Walker A/P-loop; other site 698761018099 ATP binding site [chemical binding]; other site 698761018100 Q-loop/lid; other site 698761018101 ABC transporter signature motif; other site 698761018102 Walker B; other site 698761018103 D-loop; other site 698761018104 H-loop/switch region; other site 698761018105 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761018106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018107 dimer interface [polypeptide binding]; other site 698761018108 conserved gate region; other site 698761018109 putative PBP binding loops; other site 698761018110 ABC-ATPase subunit interface; other site 698761018111 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761018112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018113 dimer interface [polypeptide binding]; other site 698761018114 conserved gate region; other site 698761018115 putative PBP binding loops; other site 698761018116 ABC-ATPase subunit interface; other site 698761018117 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761018118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761018119 substrate binding pocket [chemical binding]; other site 698761018120 membrane-bound complex binding site; other site 698761018121 hinge residues; other site 698761018122 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 698761018123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761018124 DNA-binding site [nucleotide binding]; DNA binding site 698761018125 UTRA domain; Region: UTRA; pfam07702 698761018126 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 698761018127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761018128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761018129 dimerization interface [polypeptide binding]; other site 698761018130 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698761018131 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698761018132 active site 698761018133 non-prolyl cis peptide bond; other site 698761018134 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 698761018135 hypothetical protein; Provisional; Region: PRK07550 698761018136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761018137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761018138 homodimer interface [polypeptide binding]; other site 698761018139 catalytic residue [active] 698761018140 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 698761018141 agmatinase; Region: agmatinase; TIGR01230 698761018142 oligomer interface [polypeptide binding]; other site 698761018143 putative active site [active] 698761018144 Mn binding site [ion binding]; other site 698761018145 Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014 698761018146 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 698761018147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698761018148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761018149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761018150 dimerization interface [polypeptide binding]; other site 698761018151 LysR substrate binding domain; Region: LysR_substrate; pfam03466 698761018152 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 698761018153 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698761018154 Response regulator receiver domain; Region: Response_reg; pfam00072 698761018155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698761018156 active site 698761018157 phosphorylation site [posttranslational modification] 698761018158 intermolecular recognition site; other site 698761018159 dimerization interface [polypeptide binding]; other site 698761018160 PAS fold; Region: PAS; pfam00989 698761018161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761018162 putative active site [active] 698761018163 heme pocket [chemical binding]; other site 698761018164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698761018165 HWE histidine kinase; Region: HWE_HK; cl06527 698761018166 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761018167 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761018168 active site 698761018169 catalytic tetrad [active] 698761018170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761018171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018172 dimer interface [polypeptide binding]; other site 698761018173 conserved gate region; other site 698761018174 putative PBP binding loops; other site 698761018175 ABC-ATPase subunit interface; other site 698761018176 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761018177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018178 dimer interface [polypeptide binding]; other site 698761018179 conserved gate region; other site 698761018180 putative PBP binding loops; other site 698761018181 ABC-ATPase subunit interface; other site 698761018182 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761018183 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761018184 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761018185 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761018186 Walker A/P-loop; other site 698761018187 ATP binding site [chemical binding]; other site 698761018188 Q-loop/lid; other site 698761018189 ABC transporter signature motif; other site 698761018190 Walker B; other site 698761018191 D-loop; other site 698761018192 H-loop/switch region; other site 698761018193 TOBE domain; Region: TOBE; pfam03459 698761018194 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698761018195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761018196 DNA-binding site [nucleotide binding]; DNA binding site 698761018197 FCD domain; Region: FCD; pfam07729 698761018198 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761018199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761018200 metal binding site [ion binding]; metal-binding site 698761018201 active site 698761018202 I-site; other site 698761018203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761018204 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761018205 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761018206 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698761018207 Dehydroquinase class II; Region: DHquinase_II; pfam01220 698761018208 trimer interface [polypeptide binding]; other site 698761018209 active site 698761018210 dimer interface [polypeptide binding]; other site 698761018211 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 698761018212 putative substrate binding pocket [chemical binding]; other site 698761018213 trimer interface [polypeptide binding]; other site 698761018214 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 698761018215 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698761018216 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698761018217 shikimate binding site; other site 698761018218 NAD(P) binding site [chemical binding]; other site 698761018219 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761018220 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761018221 Walker A/P-loop; other site 698761018222 ATP binding site [chemical binding]; other site 698761018223 Q-loop/lid; other site 698761018224 ABC transporter signature motif; other site 698761018225 Walker B; other site 698761018226 D-loop; other site 698761018227 H-loop/switch region; other site 698761018228 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761018229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761018230 substrate binding pocket [chemical binding]; other site 698761018231 membrane-bound complex binding site; other site 698761018232 hinge residues; other site 698761018233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018234 dimer interface [polypeptide binding]; other site 698761018235 conserved gate region; other site 698761018236 putative PBP binding loops; other site 698761018237 ABC-ATPase subunit interface; other site 698761018238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018239 dimer interface [polypeptide binding]; other site 698761018240 conserved gate region; other site 698761018241 putative PBP binding loops; other site 698761018242 ABC-ATPase subunit interface; other site 698761018243 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761018244 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761018245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761018246 DNA-binding site [nucleotide binding]; DNA binding site 698761018247 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 698761018248 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 698761018249 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 698761018250 active site 698761018251 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 698761018252 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 698761018253 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761018254 substrate binding pocket [chemical binding]; other site 698761018255 membrane-bound complex binding site; other site 698761018256 hinge residues; other site 698761018257 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 698761018258 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698761018259 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698761018260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761018261 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761018262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018263 dimer interface [polypeptide binding]; other site 698761018264 conserved gate region; other site 698761018265 ABC-ATPase subunit interface; other site 698761018266 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761018267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018268 dimer interface [polypeptide binding]; other site 698761018269 conserved gate region; other site 698761018270 putative PBP binding loops; other site 698761018271 ABC-ATPase subunit interface; other site 698761018272 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 698761018273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698761018274 motif II; other site 698761018275 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 698761018276 N- and C-terminal domain interface [polypeptide binding]; other site 698761018277 D-xylulose kinase; Region: XylB; TIGR01312 698761018278 putative active site [active] 698761018279 MgATP binding site [chemical binding]; other site 698761018280 catalytic site [active] 698761018281 metal binding site [ion binding]; metal-binding site 698761018282 putative xylulose binding site [chemical binding]; other site 698761018283 putative homodimer interface [polypeptide binding]; other site 698761018284 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761018285 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761018286 Walker A/P-loop; other site 698761018287 ATP binding site [chemical binding]; other site 698761018288 Q-loop/lid; other site 698761018289 ABC transporter signature motif; other site 698761018290 Walker B; other site 698761018291 D-loop; other site 698761018292 H-loop/switch region; other site 698761018293 TOBE domain; Region: TOBE_2; pfam08402 698761018294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761018295 classical (c) SDRs; Region: SDR_c; cd05233 698761018296 NAD(P) binding site [chemical binding]; other site 698761018297 active site 698761018298 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698761018299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761018300 DNA-binding site [nucleotide binding]; DNA binding site 698761018301 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698761018302 BtpA family; Region: BtpA; cl00440 698761018303 short chain dehydrogenase; Provisional; Region: PRK06180 698761018304 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 698761018305 NADP binding site [chemical binding]; other site 698761018306 active site 698761018307 steroid binding site; other site 698761018308 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698761018309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761018310 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761018311 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761018312 Epoxide hydrolase N terminus; Region: EHN; pfam06441 698761018313 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761018314 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698761018315 DNA-binding site [nucleotide binding]; DNA binding site 698761018316 RNA-binding motif; other site 698761018317 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 698761018318 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 698761018319 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 698761018320 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761018321 cyclase homology domain; Region: CHD; cd07302 698761018322 nucleotidyl binding site; other site 698761018323 metal binding site [ion binding]; metal-binding site 698761018324 dimer interface [polypeptide binding]; other site 698761018325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 698761018326 FecR protein; Region: FecR; pfam04773 698761018327 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 698761018328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761018329 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761018330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761018331 putative DNA binding site [nucleotide binding]; other site 698761018332 putative Zn2+ binding site [ion binding]; other site 698761018333 AsnC family; Region: AsnC_trans_reg; pfam01037 698761018334 succinic semialdehyde dehydrogenase; Region: PLN02278 698761018335 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698761018336 tetramerization interface [polypeptide binding]; other site 698761018337 NAD(P) binding site [chemical binding]; other site 698761018338 catalytic residues [active] 698761018339 hypothetical protein; Provisional; Region: PRK07482 698761018340 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761018341 inhibitor-cofactor binding pocket; inhibition site 698761018342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761018343 catalytic residue [active] 698761018344 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698761018345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761018346 DNA-binding site [nucleotide binding]; DNA binding site 698761018347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698761018348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761018349 homodimer interface [polypeptide binding]; other site 698761018350 catalytic residue [active] 698761018351 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 698761018352 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761018353 Walker A/P-loop; other site 698761018354 ATP binding site [chemical binding]; other site 698761018355 Q-loop/lid; other site 698761018356 ABC transporter signature motif; other site 698761018357 Walker B; other site 698761018358 D-loop; other site 698761018359 H-loop/switch region; other site 698761018360 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 698761018361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018362 putative PBP binding loops; other site 698761018363 dimer interface [polypeptide binding]; other site 698761018364 ABC-ATPase subunit interface; other site 698761018365 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761018366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018367 dimer interface [polypeptide binding]; other site 698761018368 conserved gate region; other site 698761018369 putative PBP binding loops; other site 698761018370 ABC-ATPase subunit interface; other site 698761018371 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 698761018372 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761018373 substrate binding pocket [chemical binding]; other site 698761018374 membrane-bound complex binding site; other site 698761018375 hinge residues; other site 698761018376 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 698761018377 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 698761018378 putative active site [active] 698761018379 Zn binding site [ion binding]; other site 698761018380 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 698761018381 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698761018382 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 698761018383 active site 698761018384 ectoine utilization protein EutC; Validated; Region: PRK08291 698761018385 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698761018386 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 698761018387 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698761018388 tetramer interface [polypeptide binding]; other site 698761018389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761018390 catalytic residue [active] 698761018391 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 698761018392 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 698761018393 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761018394 Walker A/P-loop; other site 698761018395 ATP binding site [chemical binding]; other site 698761018396 Q-loop/lid; other site 698761018397 ABC transporter signature motif; other site 698761018398 Walker B; other site 698761018399 D-loop; other site 698761018400 H-loop/switch region; other site 698761018401 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 698761018402 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698761018403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761018404 Walker A/P-loop; other site 698761018405 ATP binding site [chemical binding]; other site 698761018406 Q-loop/lid; other site 698761018407 ABC transporter signature motif; other site 698761018408 Walker B; other site 698761018409 D-loop; other site 698761018410 H-loop/switch region; other site 698761018411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761018412 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 698761018413 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761018414 active site 698761018415 cytosine deaminase; Provisional; Region: PRK05985 698761018416 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 698761018417 active site 698761018418 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698761018419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018420 dimer interface [polypeptide binding]; other site 698761018421 conserved gate region; other site 698761018422 putative PBP binding loops; other site 698761018423 ABC-ATPase subunit interface; other site 698761018424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761018425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018426 dimer interface [polypeptide binding]; other site 698761018427 conserved gate region; other site 698761018428 putative PBP binding loops; other site 698761018429 ABC-ATPase subunit interface; other site 698761018430 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761018431 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 698761018432 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761018433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761018434 DNA-binding site [nucleotide binding]; DNA binding site 698761018435 FCD domain; Region: FCD; pfam07729 698761018436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698761018437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698761018438 DNA binding residues [nucleotide binding] 698761018439 dimerization interface [polypeptide binding]; other site 698761018440 PRC-barrel domain; Region: PRC; pfam05239 698761018441 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761018442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761018443 DNA binding site [nucleotide binding] 698761018444 domain linker motif; other site 698761018445 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 698761018446 ligand binding site [chemical binding]; other site 698761018447 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698761018448 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761018449 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698761018450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018451 dimer interface [polypeptide binding]; other site 698761018452 conserved gate region; other site 698761018453 putative PBP binding loops; other site 698761018454 ABC-ATPase subunit interface; other site 698761018455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761018456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018457 dimer interface [polypeptide binding]; other site 698761018458 conserved gate region; other site 698761018459 putative PBP binding loops; other site 698761018460 ABC-ATPase subunit interface; other site 698761018461 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 698761018462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761018463 Walker A/P-loop; other site 698761018464 ATP binding site [chemical binding]; other site 698761018465 Q-loop/lid; other site 698761018466 ABC transporter signature motif; other site 698761018467 Walker B; other site 698761018468 D-loop; other site 698761018469 H-loop/switch region; other site 698761018470 alpha-glucosidase; Provisional; Region: PRK10137 698761018471 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 698761018472 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 698761018473 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698761018474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761018475 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761018476 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761018477 active site 698761018478 catalytic tetrad [active] 698761018479 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698761018480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761018481 putative substrate translocation pore; other site 698761018482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761018483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761018484 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 698761018485 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 698761018486 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761018487 dimerization interface [polypeptide binding]; other site 698761018488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 698761018489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761018490 dimer interface [polypeptide binding]; other site 698761018491 putative CheW interface [polypeptide binding]; other site 698761018492 Uncharacterized conserved protein [Function unknown]; Region: COG3482 698761018493 Uncharacterized conserved protein [Function unknown]; Region: COG1944 698761018494 YcaO-like family; Region: YcaO; pfam02624 698761018495 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 698761018496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 698761018497 TPR motif; other site 698761018498 binding surface 698761018499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761018500 binding surface 698761018501 TPR motif; other site 698761018502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761018503 sequence-specific DNA binding site [nucleotide binding]; other site 698761018504 salt bridge; other site 698761018505 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 698761018506 acetylornithine deacetylase; Provisional; Region: PRK07522 698761018507 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 698761018508 metal binding site [ion binding]; metal-binding site 698761018509 putative dimer interface [polypeptide binding]; other site 698761018510 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698761018511 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 698761018512 putative ligand binding site [chemical binding]; other site 698761018513 NAD binding site [chemical binding]; other site 698761018514 dimerization interface [polypeptide binding]; other site 698761018515 catalytic site [active] 698761018516 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 698761018517 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698761018518 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698761018519 NAD(P) binding site [chemical binding]; other site 698761018520 catalytic residues [active] 698761018521 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 698761018522 tartrate dehydrogenase; Region: TTC; TIGR02089 698761018523 succinic semialdehyde dehydrogenase; Region: PLN02278 698761018524 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698761018525 tetramerization interface [polypeptide binding]; other site 698761018526 NAD(P) binding site [chemical binding]; other site 698761018527 catalytic residues [active] 698761018528 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698761018529 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761018530 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 698761018531 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 698761018532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698761018533 hypothetical protein; Provisional; Region: PRK05965 698761018534 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698761018535 inhibitor-cofactor binding pocket; inhibition site 698761018536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698761018537 catalytic residue [active] 698761018538 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 698761018539 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 698761018540 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761018541 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698761018542 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761018543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018544 dimer interface [polypeptide binding]; other site 698761018545 conserved gate region; other site 698761018546 putative PBP binding loops; other site 698761018547 ABC-ATPase subunit interface; other site 698761018548 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761018549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018550 dimer interface [polypeptide binding]; other site 698761018551 conserved gate region; other site 698761018552 ABC-ATPase subunit interface; other site 698761018553 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761018554 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761018555 Walker A/P-loop; other site 698761018556 ATP binding site [chemical binding]; other site 698761018557 Q-loop/lid; other site 698761018558 ABC transporter signature motif; other site 698761018559 Walker B; other site 698761018560 D-loop; other site 698761018561 H-loop/switch region; other site 698761018562 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761018563 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761018564 Walker A/P-loop; other site 698761018565 ATP binding site [chemical binding]; other site 698761018566 Q-loop/lid; other site 698761018567 ABC transporter signature motif; other site 698761018568 Walker B; other site 698761018569 D-loop; other site 698761018570 H-loop/switch region; other site 698761018571 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761018572 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 698761018573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761018574 putative DNA binding site [nucleotide binding]; other site 698761018575 putative Zn2+ binding site [ion binding]; other site 698761018576 AsnC family; Region: AsnC_trans_reg; pfam01037 698761018577 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761018578 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761018579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761018580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761018581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761018582 dimerization interface [polypeptide binding]; other site 698761018583 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 698761018584 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698761018585 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698761018586 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 698761018587 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 698761018588 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 698761018589 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 698761018590 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 698761018591 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761018592 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 698761018593 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698761018594 MULE transposase domain; Region: MULE; pfam10551 698761018595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761018596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761018597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761018598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761018599 dimerization interface [polypeptide binding]; other site 698761018600 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 698761018601 Flavoprotein; Region: Flavoprotein; pfam02441 698761018602 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 698761018603 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698761018604 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698761018605 tetramer interface [polypeptide binding]; other site 698761018606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761018607 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698761018608 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698761018609 active site 698761018610 non-prolyl cis peptide bond; other site 698761018611 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761018612 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 698761018613 Flavin binding site [chemical binding]; other site 698761018614 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 698761018615 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761018616 active site 698761018617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018618 dimer interface [polypeptide binding]; other site 698761018619 conserved gate region; other site 698761018620 ABC-ATPase subunit interface; other site 698761018621 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698761018622 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 698761018623 Walker A/P-loop; other site 698761018624 ATP binding site [chemical binding]; other site 698761018625 Q-loop/lid; other site 698761018626 ABC transporter signature motif; other site 698761018627 Walker B; other site 698761018628 D-loop; other site 698761018629 H-loop/switch region; other site 698761018630 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 698761018631 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698761018632 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698761018633 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761018634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761018635 DNA-binding site [nucleotide binding]; DNA binding site 698761018636 FCD domain; Region: FCD; pfam07729 698761018637 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 698761018638 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 698761018639 putative ligand binding site [chemical binding]; other site 698761018640 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761018641 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761018642 TM-ABC transporter signature motif; other site 698761018643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761018644 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 698761018645 TM-ABC transporter signature motif; other site 698761018646 Isochorismatase family; Region: Isochorismatase; pfam00857 698761018647 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698761018648 catalytic triad [active] 698761018649 conserved cis-peptide bond; other site 698761018650 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 698761018651 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 698761018652 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761018653 Walker A/P-loop; other site 698761018654 ATP binding site [chemical binding]; other site 698761018655 Q-loop/lid; other site 698761018656 ABC transporter signature motif; other site 698761018657 Walker B; other site 698761018658 D-loop; other site 698761018659 H-loop/switch region; other site 698761018660 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761018661 Isochorismatase family; Region: Isochorismatase; pfam00857 698761018662 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698761018663 catalytic triad [active] 698761018664 conserved cis-peptide bond; other site 698761018665 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 698761018666 allophanate hydrolase; Provisional; Region: PRK08186 698761018667 Amidase; Region: Amidase; cl11426 698761018668 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698761018669 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 698761018670 putative NADP binding site [chemical binding]; other site 698761018671 short chain dehydrogenase; Validated; Region: PRK08264 698761018672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761018673 NAD(P) binding site [chemical binding]; other site 698761018674 active site 698761018675 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698761018676 MarR family; Region: MarR_2; pfam12802 698761018677 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761018678 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 698761018679 benzoate transport; Region: 2A0115; TIGR00895 698761018680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761018681 putative substrate translocation pore; other site 698761018682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761018683 Isochorismatase family; Region: Isochorismatase; pfam00857 698761018684 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 698761018685 catalytic triad [active] 698761018686 substrate binding site [chemical binding]; other site 698761018687 domain interfaces; other site 698761018688 conserved cis-peptide bond; other site 698761018689 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 698761018690 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698761018691 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698761018692 FAD binding domain; Region: FAD_binding_3; pfam01494 698761018693 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 698761018694 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698761018695 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 698761018696 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761018697 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 698761018698 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 698761018699 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761018700 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 698761018701 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698761018702 Cytochrome c; Region: Cytochrom_C; pfam00034 698761018703 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 698761018704 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 698761018705 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 698761018706 Trehalase; Region: Trehalase; cl17346 698761018707 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698761018708 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 698761018709 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761018710 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761018711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018712 putative PBP binding loops; other site 698761018713 dimer interface [polypeptide binding]; other site 698761018714 ABC-ATPase subunit interface; other site 698761018715 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761018716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018717 dimer interface [polypeptide binding]; other site 698761018718 conserved gate region; other site 698761018719 putative PBP binding loops; other site 698761018720 ABC-ATPase subunit interface; other site 698761018721 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761018722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761018723 Walker A/P-loop; other site 698761018724 ATP binding site [chemical binding]; other site 698761018725 Q-loop/lid; other site 698761018726 ABC transporter signature motif; other site 698761018727 Walker B; other site 698761018728 D-loop; other site 698761018729 H-loop/switch region; other site 698761018730 TOBE domain; Region: TOBE_2; pfam08402 698761018731 Isochorismatase family; Region: Isochorismatase; pfam00857 698761018732 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698761018733 catalytic triad [active] 698761018734 conserved cis-peptide bond; other site 698761018735 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698761018736 MarR family; Region: MarR_2; pfam12802 698761018737 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 698761018738 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 698761018739 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 698761018740 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 698761018741 pyruvate, phosphate dikinase; Region: pyru_phos_dikin; TIGR01828 698761018742 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698761018743 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 698761018744 conserved cys residue [active] 698761018745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761018746 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698761018747 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 698761018748 putative NAD(P) binding site [chemical binding]; other site 698761018749 putative substrate binding site [chemical binding]; other site 698761018750 catalytic Zn binding site [ion binding]; other site 698761018751 structural Zn binding site [ion binding]; other site 698761018752 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761018753 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761018754 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698761018755 Cytochrome C' Region: Cytochrom_C_2; cl01610 698761018756 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 698761018757 active site 698761018758 catalytic residues [active] 698761018759 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 698761018760 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761018761 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 698761018762 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698761018763 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 698761018764 Walker A/P-loop; other site 698761018765 ATP binding site [chemical binding]; other site 698761018766 Q-loop/lid; other site 698761018767 ABC transporter signature motif; other site 698761018768 Walker B; other site 698761018769 D-loop; other site 698761018770 H-loop/switch region; other site 698761018771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698761018772 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 698761018773 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698761018774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018775 dimer interface [polypeptide binding]; other site 698761018776 conserved gate region; other site 698761018777 putative PBP binding loops; other site 698761018778 ABC-ATPase subunit interface; other site 698761018779 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698761018780 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698761018781 Walker A/P-loop; other site 698761018782 ATP binding site [chemical binding]; other site 698761018783 Q-loop/lid; other site 698761018784 ABC transporter signature motif; other site 698761018785 Walker B; other site 698761018786 D-loop; other site 698761018787 H-loop/switch region; other site 698761018788 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698761018789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698761018790 substrate binding pocket [chemical binding]; other site 698761018791 membrane-bound complex binding site; other site 698761018792 hinge residues; other site 698761018793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761018794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761018795 DNA binding site [nucleotide binding] 698761018796 domain linker motif; other site 698761018797 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698761018798 dimerization interface [polypeptide binding]; other site 698761018799 ligand binding site [chemical binding]; other site 698761018800 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 698761018801 Found in ATP-dependent protease La (LON); Region: LON; smart00464 698761018802 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698761018803 oligomeric interface; other site 698761018804 putative active site [active] 698761018805 homodimer interface [polypeptide binding]; other site 698761018806 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 698761018807 hypothetical protein; Provisional; Region: PRK06102 698761018808 Amidase; Region: Amidase; cl11426 698761018809 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698761018810 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698761018811 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698761018812 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698761018813 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 698761018814 active site 698761018815 catalytic site [active] 698761018816 Zn binding site [ion binding]; other site 698761018817 tetramer interface [polypeptide binding]; other site 698761018818 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 698761018819 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761018820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761018821 Walker A/P-loop; other site 698761018822 ATP binding site [chemical binding]; other site 698761018823 Q-loop/lid; other site 698761018824 ABC transporter signature motif; other site 698761018825 Walker B; other site 698761018826 D-loop; other site 698761018827 H-loop/switch region; other site 698761018828 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698761018829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698761018830 classical (c) SDRs; Region: SDR_c; cd05233 698761018831 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761018832 NAD(P) binding site [chemical binding]; other site 698761018833 active site 698761018834 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698761018835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698761018836 NAD(P) binding site [chemical binding]; other site 698761018837 active site 698761018838 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761018839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018840 dimer interface [polypeptide binding]; other site 698761018841 conserved gate region; other site 698761018842 putative PBP binding loops; other site 698761018843 ABC-ATPase subunit interface; other site 698761018844 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698761018845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018846 dimer interface [polypeptide binding]; other site 698761018847 conserved gate region; other site 698761018848 putative PBP binding loops; other site 698761018849 ABC-ATPase subunit interface; other site 698761018850 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698761018851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698761018852 Walker A/P-loop; other site 698761018853 ATP binding site [chemical binding]; other site 698761018854 Q-loop/lid; other site 698761018855 ABC transporter signature motif; other site 698761018856 Walker B; other site 698761018857 D-loop; other site 698761018858 H-loop/switch region; other site 698761018859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698761018860 DNA-binding site [nucleotide binding]; DNA binding site 698761018861 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698761018862 FCD domain; Region: FCD; pfam07729 698761018863 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 698761018864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698761018865 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 698761018866 Integrase core domain; Region: rve; pfam00665 698761018867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761018868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761018869 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761018870 putative effector binding pocket; other site 698761018871 dimerization interface [polypeptide binding]; other site 698761018872 NmrA-like family; Region: NmrA; pfam05368 698761018873 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 698761018874 NADP binding site [chemical binding]; other site 698761018875 active site 698761018876 regulatory binding site [polypeptide binding]; other site 698761018877 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 698761018878 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 698761018879 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698761018880 putative active site [active] 698761018881 catalytic residue [active] 698761018882 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 698761018883 mannonate dehydratase; Region: uxuA; TIGR00695 698761018884 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 698761018885 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 698761018886 active site 698761018887 catalytic site [active] 698761018888 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698761018889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018890 dimer interface [polypeptide binding]; other site 698761018891 conserved gate region; other site 698761018892 putative PBP binding loops; other site 698761018893 ABC-ATPase subunit interface; other site 698761018894 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761018895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761018896 dimer interface [polypeptide binding]; other site 698761018897 conserved gate region; other site 698761018898 putative PBP binding loops; other site 698761018899 ABC-ATPase subunit interface; other site 698761018900 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698761018901 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761018902 Walker A/P-loop; other site 698761018903 ATP binding site [chemical binding]; other site 698761018904 Q-loop/lid; other site 698761018905 ABC transporter signature motif; other site 698761018906 Walker B; other site 698761018907 D-loop; other site 698761018908 H-loop/switch region; other site 698761018909 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761018910 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698761018911 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761018912 Walker A/P-loop; other site 698761018913 ATP binding site [chemical binding]; other site 698761018914 Q-loop/lid; other site 698761018915 ABC transporter signature motif; other site 698761018916 Walker B; other site 698761018917 D-loop; other site 698761018918 H-loop/switch region; other site 698761018919 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698761018920 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761018921 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 698761018922 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761018923 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761018924 DNA binding site [nucleotide binding] 698761018925 domain linker motif; other site 698761018926 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698761018927 ligand binding site [chemical binding]; other site 698761018928 dimerization interface [polypeptide binding]; other site 698761018929 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 698761018930 PLD-like domain; Region: PLDc_2; pfam13091 698761018931 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 698761018932 putative active site [active] 698761018933 catalytic site [active] 698761018934 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 698761018935 putative active site [active] 698761018936 catalytic site [active] 698761018937 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 698761018938 FAD binding domain; Region: FAD_binding_2; pfam00890 698761018939 acetate kinase; Provisional; Region: PRK07058 698761018940 propionate/acetate kinase; Provisional; Region: PRK12379 698761018941 putative phosphoketolase; Provisional; Region: PRK05261 698761018942 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 698761018943 TPP-binding site; other site 698761018944 XFP C-terminal domain; Region: XFP_C; pfam09363 698761018945 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 698761018946 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698761018947 substrate binding site [chemical binding]; other site 698761018948 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 698761018949 BON domain; Region: BON; pfam04972 698761018950 MgtC family; Region: MgtC; pfam02308 698761018951 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761018952 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761018953 metal binding site [ion binding]; metal-binding site 698761018954 active site 698761018955 I-site; other site 698761018956 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 698761018957 Transforming growth factor beta like domain; Region: TGF_beta; cl02510 698761018958 hypothetical protein; Provisional; Region: PRK08317 698761018959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698761018960 S-adenosylmethionine binding site [chemical binding]; other site 698761018961 Cache domain; Region: Cache_1; pfam02743 698761018962 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698761018963 dimerization interface [polypeptide binding]; other site 698761018964 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 698761018965 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 698761018966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 698761018967 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 698761018968 anti sigma factor interaction site; other site 698761018969 regulatory phosphorylation site [posttranslational modification]; other site 698761018970 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 698761018971 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698761018972 NAD binding site [chemical binding]; other site 698761018973 putative substrate binding site 2 [chemical binding]; other site 698761018974 putative substrate binding site 1 [chemical binding]; other site 698761018975 active site 698761018976 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698761018977 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698761018978 NAD binding site [chemical binding]; other site 698761018979 homodimer interface [polypeptide binding]; other site 698761018980 active site 698761018981 substrate binding site [chemical binding]; other site 698761018982 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 698761018983 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698761018984 active site 698761018985 Cellulose synthase-like protein; Region: PLN02893 698761018986 Protein of unknown function (DUF995); Region: DUF995; pfam06191 698761018987 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 698761018988 Protein of unknown function (DUF995); Region: DUF995; pfam06191 698761018989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698761018990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761018991 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761018992 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761018993 DNA binding site [nucleotide binding] 698761018994 domain linker motif; other site 698761018995 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698761018996 dimerization interface [polypeptide binding]; other site 698761018997 ligand binding site [chemical binding]; other site 698761018998 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 698761018999 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 698761019000 ligand binding site [chemical binding]; other site 698761019001 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 698761019002 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 698761019003 Walker A/P-loop; other site 698761019004 ATP binding site [chemical binding]; other site 698761019005 Q-loop/lid; other site 698761019006 ABC transporter signature motif; other site 698761019007 Walker B; other site 698761019008 D-loop; other site 698761019009 H-loop/switch region; other site 698761019010 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 698761019011 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 698761019012 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698761019013 TM-ABC transporter signature motif; other site 698761019014 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 698761019015 active site 698761019016 catalytic site [active] 698761019017 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 698761019018 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 698761019019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698761019020 putative DNA binding site [nucleotide binding]; other site 698761019021 putative Zn2+ binding site [ion binding]; other site 698761019022 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761019023 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761019024 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 698761019025 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698761019026 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 698761019027 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698761019028 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698761019029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761019030 dimer interface [polypeptide binding]; other site 698761019031 conserved gate region; other site 698761019032 putative PBP binding loops; other site 698761019033 ABC-ATPase subunit interface; other site 698761019034 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698761019035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761019036 dimer interface [polypeptide binding]; other site 698761019037 conserved gate region; other site 698761019038 putative PBP binding loops; other site 698761019039 ABC-ATPase subunit interface; other site 698761019040 MarR family; Region: MarR; pfam01047 698761019041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761019042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 698761019043 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 698761019044 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 698761019045 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698761019046 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698761019047 Walker A/P-loop; other site 698761019048 ATP binding site [chemical binding]; other site 698761019049 Q-loop/lid; other site 698761019050 ABC transporter signature motif; other site 698761019051 Walker B; other site 698761019052 D-loop; other site 698761019053 H-loop/switch region; other site 698761019054 TOBE domain; Region: TOBE_2; pfam08402 698761019055 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698761019056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698761019057 metal binding site [ion binding]; metal-binding site 698761019058 active site 698761019059 I-site; other site 698761019060 Chromate transporter; Region: Chromate_transp; pfam02417 698761019061 Chromate transporter; Region: Chromate_transp; pfam02417 698761019062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761019063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761019064 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 698761019065 putative dimerization interface [polypeptide binding]; other site 698761019066 putative substrate binding pocket [chemical binding]; other site 698761019067 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698761019068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698761019069 nucleotide binding site [chemical binding]; other site 698761019070 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 698761019071 Domain interface; other site 698761019072 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 698761019073 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 698761019074 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698761019075 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 698761019076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698761019077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761019078 dimer interface [polypeptide binding]; other site 698761019079 conserved gate region; other site 698761019080 putative PBP binding loops; other site 698761019081 ABC-ATPase subunit interface; other site 698761019082 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698761019083 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 698761019084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698761019085 dimer interface [polypeptide binding]; other site 698761019086 conserved gate region; other site 698761019087 putative PBP binding loops; other site 698761019088 ABC-ATPase subunit interface; other site 698761019089 Predicted amidohydrolase [General function prediction only]; Region: COG3964 698761019090 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 698761019091 active site 698761019092 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698761019093 homotrimer interaction site [polypeptide binding]; other site 698761019094 putative active site [active] 698761019095 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 698761019096 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698761019097 Bacterial transcriptional regulator; Region: IclR; pfam01614 698761019098 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 698761019099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761019100 catalytic residue [active] 698761019101 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698761019102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761019103 Walker A/P-loop; other site 698761019104 ATP binding site [chemical binding]; other site 698761019105 Q-loop/lid; other site 698761019106 ABC transporter signature motif; other site 698761019107 Walker B; other site 698761019108 D-loop; other site 698761019109 H-loop/switch region; other site 698761019110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698761019111 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698761019112 Walker A/P-loop; other site 698761019113 ATP binding site [chemical binding]; other site 698761019114 Q-loop/lid; other site 698761019115 ABC transporter signature motif; other site 698761019116 Walker B; other site 698761019117 D-loop; other site 698761019118 H-loop/switch region; other site 698761019119 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 698761019120 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698761019121 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698761019122 DNA binding site [nucleotide binding] 698761019123 domain linker motif; other site 698761019124 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 698761019125 dimerization interface [polypeptide binding]; other site 698761019126 ligand binding site [chemical binding]; other site 698761019127 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 698761019128 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698761019129 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 698761019130 active site 698761019131 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 698761019132 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 698761019133 ornithine decarboxylase; Provisional; Region: PRK13578 698761019134 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698761019135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698761019136 catalytic residue [active] 698761019137 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 698761019138 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698761019139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698761019140 Coenzyme A binding pocket [chemical binding]; other site 698761019141 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698761019142 active site 698761019143 DNA polymerase IV; Validated; Region: PRK02406 698761019144 DNA binding site [nucleotide binding] 698761019145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761019146 non-specific DNA binding site [nucleotide binding]; other site 698761019147 salt bridge; other site 698761019148 sequence-specific DNA binding site [nucleotide binding]; other site 698761019149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761019150 putative substrate translocation pore; other site 698761019151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761019152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761019153 Amino acid permease; Region: AA_permease_2; pfam13520 698761019154 Uncharacterized conserved protein [Function unknown]; Region: COG3665 698761019155 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698761019156 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761019157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698761019158 PAS fold; Region: PAS_3; pfam08447 698761019159 putative active site [active] 698761019160 heme pocket [chemical binding]; other site 698761019161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 698761019162 putative CheW interface [polypeptide binding]; other site 698761019163 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698761019164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698761019165 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 698761019166 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698761019167 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 698761019168 FMN-binding pocket [chemical binding]; other site 698761019169 flavin binding motif; other site 698761019170 phosphate binding motif [ion binding]; other site 698761019171 beta-alpha-beta structure motif; other site 698761019172 NAD binding pocket [chemical binding]; other site 698761019173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698761019174 catalytic loop [active] 698761019175 iron binding site [ion binding]; other site 698761019176 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 698761019177 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761019178 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 698761019179 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698761019180 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698761019181 homodimer interface [polypeptide binding]; other site 698761019182 NADP binding site [chemical binding]; other site 698761019183 substrate binding site [chemical binding]; other site 698761019184 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 698761019185 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 698761019186 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 698761019187 putative active site [active] 698761019188 putative substrate binding site [chemical binding]; other site 698761019189 putative cosubstrate binding site; other site 698761019190 catalytic site [active] 698761019191 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 698761019192 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698761019193 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 698761019194 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 698761019195 active site 698761019196 FMN binding site [chemical binding]; other site 698761019197 substrate binding site [chemical binding]; other site 698761019198 3Fe-4S cluster binding site [ion binding]; other site 698761019199 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 698761019200 domain_subunit interface; other site 698761019201 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 698761019202 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 698761019203 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 698761019204 putative active site [active] 698761019205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698761019206 non-specific DNA binding site [nucleotide binding]; other site 698761019207 salt bridge; other site 698761019208 sequence-specific DNA binding site [nucleotide binding]; other site 698761019209 Cupin domain; Region: Cupin_2; pfam07883 698761019210 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 698761019211 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 698761019212 conserved cys residue [active] 698761019213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698761019214 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 698761019215 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698761019216 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 698761019217 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 698761019218 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698761019219 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698761019220 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 698761019221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761019222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761019223 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 698761019224 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 698761019225 putative C-terminal domain interface [polypeptide binding]; other site 698761019226 putative GSH binding site (G-site) [chemical binding]; other site 698761019227 putative dimer interface [polypeptide binding]; other site 698761019228 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 698761019229 putative N-terminal domain interface [polypeptide binding]; other site 698761019230 putative dimer interface [polypeptide binding]; other site 698761019231 putative substrate binding pocket (H-site) [chemical binding]; other site 698761019232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 698761019233 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698761019234 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698761019235 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 698761019236 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 698761019237 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698761019238 PYR/PP interface [polypeptide binding]; other site 698761019239 dimer interface [polypeptide binding]; other site 698761019240 TPP binding site [chemical binding]; other site 698761019241 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 698761019242 TPP-binding site [chemical binding]; other site 698761019243 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 698761019244 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 698761019245 active site 698761019246 catalytic residues [active] 698761019247 metal binding site [ion binding]; metal-binding site 698761019248 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 698761019249 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698761019250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698761019251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698761019252 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698761019253 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698761019254 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698761019255 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 698761019256 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698761019257 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698761019258 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 698761019259 active site 698761019260 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 698761019261 dimer interface [polypeptide binding]; other site 698761019262 non-prolyl cis peptide bond; other site 698761019263 insertion regions; other site 698761019264 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698761019265 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 698761019266 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 698761019267 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 698761019268 putative DNA binding site [nucleotide binding]; other site 698761019269 putative homodimer interface [polypeptide binding]; other site 698761019270 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 698761019271 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 698761019272 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 698761019273 active site 698761019274 DNA binding site [nucleotide binding] 698761019275 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 698761019276 DNA binding site [nucleotide binding] 698761019277 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 698761019278 nucleotide binding site [chemical binding]; other site 698761019279 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 698761019280 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 698761019281 putative DNA binding site [nucleotide binding]; other site 698761019282 putative homodimer interface [polypeptide binding]; other site 698761019283 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698761019284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761019285 putative substrate translocation pore; other site 698761019286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761019287 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 698761019288 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761019289 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761019290 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 698761019291 Fe-S cluster binding site [ion binding]; other site 698761019292 active site 698761019293 Protein of unknown function (DUF982); Region: DUF982; pfam06169 698761019294 RNA polymerase sigma factor; Provisional; Region: PRK12547 698761019295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698761019296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698761019297 DNA binding residues [nucleotide binding] 698761019298 Protein of unknown function DUF72; Region: DUF72; pfam01904 698761019299 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698761019300 DNA-binding site [nucleotide binding]; DNA binding site 698761019301 RNA-binding motif; other site 698761019302 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 698761019303 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 698761019304 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 698761019305 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 698761019306 multidrug efflux protein; Reviewed; Region: PRK09579 698761019307 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698761019308 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761019309 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761019310 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 698761019311 dimer interface [polypeptide binding]; other site 698761019312 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 698761019313 Sel1-like repeats; Region: SEL1; smart00671 698761019314 Sel1-like repeats; Region: SEL1; smart00671 698761019315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698761019316 binding surface 698761019317 TPR motif; other site 698761019318 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698761019319 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698761019320 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698761019321 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698761019322 intersubunit interface [polypeptide binding]; other site 698761019323 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698761019324 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698761019325 ABC-ATPase subunit interface; other site 698761019326 dimer interface [polypeptide binding]; other site 698761019327 putative PBP binding regions; other site 698761019328 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698761019329 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698761019330 Walker A/P-loop; other site 698761019331 ATP binding site [chemical binding]; other site 698761019332 Q-loop/lid; other site 698761019333 ABC transporter signature motif; other site 698761019334 Walker B; other site 698761019335 D-loop; other site 698761019336 H-loop/switch region; other site 698761019337 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 698761019338 classical (c) SDRs; Region: SDR_c; cd05233 698761019339 NAD(P) binding site [chemical binding]; other site 698761019340 active site 698761019341 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 698761019342 oligomeric interface; other site 698761019343 putative active site [active] 698761019344 homodimer interface [polypeptide binding]; other site 698761019345 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 698761019346 transcriptional regulator; Provisional; Region: PRK10632 698761019347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761019348 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 698761019349 putative effector binding pocket; other site 698761019350 dimerization interface [polypeptide binding]; other site 698761019351 multidrug resistance protein MdtN; Provisional; Region: PRK10476 698761019352 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 698761019353 HlyD family secretion protein; Region: HlyD_3; pfam13437 698761019354 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698761019355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761019356 putative substrate translocation pore; other site 698761019357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761019358 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698761019359 cyclase homology domain; Region: CHD; cd07302 698761019360 nucleotidyl binding site; other site 698761019361 metal binding site [ion binding]; metal-binding site 698761019362 dimer interface [polypeptide binding]; other site 698761019363 Porin subfamily; Region: Porin_2; pfam02530 698761019364 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 698761019365 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698761019366 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 698761019367 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698761019368 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 698761019369 Multicopper oxidase; Region: Cu-oxidase; pfam00394 698761019370 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 698761019371 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 698761019372 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 698761019373 DNA binding residues [nucleotide binding] 698761019374 dimer interface [polypeptide binding]; other site 698761019375 copper binding site [ion binding]; other site 698761019376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761019377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761019378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698761019379 dimerization interface [polypeptide binding]; other site 698761019380 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698761019381 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698761019382 active site 698761019383 catalytic tetrad [active] 698761019384 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698761019385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761019386 putative substrate translocation pore; other site 698761019387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698761019388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698761019389 putative substrate translocation pore; other site 698761019390 Epoxide hydrolase N terminus; Region: EHN; pfam06441 698761019391 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698761019392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 698761019393 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 698761019394 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 698761019395 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 698761019396 metal ion-dependent adhesion site (MIDAS); other site 698761019397 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 698761019398 active site 698761019399 catalytic site [active] 698761019400 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698761019401 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 698761019402 putative active site [active] 698761019403 catalytic triad [active] 698761019404 putative dimer interface [polypeptide binding]; other site 698761019405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698761019406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698761019407 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 698761019408 dimerization interface [polypeptide binding]; other site 698761019409 substrate binding pocket [chemical binding]; other site 698761019410 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 698761019411 MerR family regulatory protein; Region: MerR; pfam00376 698761019412 DNA binding residues [nucleotide binding] 698761019413 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698761019414 P-loop; other site 698761019415 Magnesium ion binding site [ion binding]; other site 698761019416 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698761019417 Magnesium ion binding site [ion binding]; other site 698761019418 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 698761019419 ParB-like nuclease domain; Region: ParBc; pfam02195 698761019420 replication initiation protein RepC; Provisional; Region: PRK13824 698761019421 Replication protein C N-terminal domain; Region: RP-C; pfam03428 698761019422 Replication protein C C-terminal region; Region: RP-C_C; pfam11800