-- dump date 20140620_023847 -- class Genbank::misc_feature -- table misc_feature_note -- id note 365046000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 365046000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 365046000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046000004 Walker A motif; other site 365046000005 ATP binding site [chemical binding]; other site 365046000006 Walker B motif; other site 365046000007 arginine finger; other site 365046000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 365046000009 DnaA box-binding interface [nucleotide binding]; other site 365046000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 365046000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 365046000012 putative DNA binding surface [nucleotide binding]; other site 365046000013 dimer interface [polypeptide binding]; other site 365046000014 beta-clamp/clamp loader binding surface; other site 365046000015 beta-clamp/translesion DNA polymerase binding surface; other site 365046000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 365046000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046000018 ATP binding site [chemical binding]; other site 365046000019 Mg2+ binding site [ion binding]; other site 365046000020 G-X-G motif; other site 365046000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 365046000022 anchoring element; other site 365046000023 dimer interface [polypeptide binding]; other site 365046000024 ATP binding site [chemical binding]; other site 365046000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 365046000026 active site 365046000027 putative metal-binding site [ion binding]; other site 365046000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 365046000029 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 365046000030 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 365046000031 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 365046000032 DEAD-like helicases superfamily; Region: DEXDc; smart00487 365046000033 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 365046000034 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 365046000035 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 365046000036 AAA domain; Region: AAA_22; pfam13401 365046000037 Uncharacterized conserved protein [Function unknown]; Region: COG1700 365046000038 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 365046000039 Protein of unknown function (DUF524); Region: DUF524; pfam04411 365046000040 Tannase and feruloyl esterase; Region: Tannase; pfam07519 365046000041 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 365046000042 active site 365046000043 catalytic site [active] 365046000044 substrate binding site [chemical binding]; other site 365046000045 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 365046000046 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 365046000047 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 365046000048 metal binding site [ion binding]; metal-binding site 365046000049 substrate binding pocket [chemical binding]; other site 365046000050 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 365046000051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046000053 dimerization interface [polypeptide binding]; other site 365046000054 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 365046000055 NnrU protein; Region: NnrU; pfam07298 365046000056 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 365046000057 active site 365046000058 NTP binding site [chemical binding]; other site 365046000059 metal binding triad [ion binding]; metal-binding site 365046000060 antibiotic binding site [chemical binding]; other site 365046000061 Protein of unknown function DUF86; Region: DUF86; cl01031 365046000062 putative transporter; Provisional; Region: PRK12382 365046000063 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 365046000064 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 365046000065 active site 365046000066 iron coordination sites [ion binding]; other site 365046000067 substrate binding pocket [chemical binding]; other site 365046000068 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046000069 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 365046000070 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046000071 catalytic loop [active] 365046000072 iron binding site [ion binding]; other site 365046000073 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 365046000074 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 365046000075 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 365046000076 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 365046000077 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 365046000078 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046000079 PAS domain; Region: PAS_9; pfam13426 365046000080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046000081 putative active site [active] 365046000082 heme pocket [chemical binding]; other site 365046000083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046000084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046000085 dimer interface [polypeptide binding]; other site 365046000086 phosphorylation site [posttranslational modification] 365046000087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046000088 ATP binding site [chemical binding]; other site 365046000089 Mg2+ binding site [ion binding]; other site 365046000090 G-X-G motif; other site 365046000091 Response regulator receiver domain; Region: Response_reg; pfam00072 365046000092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046000093 active site 365046000094 phosphorylation site [posttranslational modification] 365046000095 intermolecular recognition site; other site 365046000096 dimerization interface [polypeptide binding]; other site 365046000097 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 365046000098 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 365046000099 classical (c) SDRs; Region: SDR_c; cd05233 365046000100 NAD(P) binding site [chemical binding]; other site 365046000101 active site 365046000102 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 365046000103 classical (c) SDRs; Region: SDR_c; cd05233 365046000104 NAD(P) binding site [chemical binding]; other site 365046000105 active site 365046000106 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 365046000107 putative hydrophobic ligand binding site [chemical binding]; other site 365046000108 cell division topological specificity factor MinE; Provisional; Region: PRK13989 365046000109 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 365046000110 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 365046000111 Switch I; other site 365046000112 Switch II; other site 365046000113 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 365046000114 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 365046000115 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 365046000116 Fe-S cluster binding site [ion binding]; other site 365046000117 active site 365046000118 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 365046000119 Predicted integral membrane protein [Function unknown]; Region: COG0392 365046000120 cardiolipin synthase 2; Provisional; Region: PRK11263 365046000121 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 365046000122 putative active site [active] 365046000123 catalytic site [active] 365046000124 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 365046000125 putative active site [active] 365046000126 catalytic site [active] 365046000127 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 365046000128 putative catalytic site [active] 365046000129 putative metal binding site [ion binding]; other site 365046000130 putative phosphate binding site [ion binding]; other site 365046000131 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 365046000132 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 365046000133 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 365046000134 LrgA family; Region: LrgA; pfam03788 365046000135 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 365046000136 LTXXQ motif family protein; Region: LTXXQ; pfam07813 365046000137 Pirin-related protein [General function prediction only]; Region: COG1741 365046000138 Pirin; Region: Pirin; pfam02678 365046000139 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 365046000140 Transglycosylase; Region: Transgly; pfam00912 365046000141 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 365046000142 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 365046000143 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 365046000144 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 365046000145 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 365046000146 metal ion-dependent adhesion site (MIDAS); other site 365046000147 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 365046000148 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046000149 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 365046000150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 365046000151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046000152 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 365046000153 sensory histidine kinase CreC; Provisional; Region: PRK11100 365046000154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046000155 dimer interface [polypeptide binding]; other site 365046000156 phosphorylation site [posttranslational modification] 365046000157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046000158 ATP binding site [chemical binding]; other site 365046000159 Mg2+ binding site [ion binding]; other site 365046000160 G-X-G motif; other site 365046000161 DNA-binding response regulator CreB; Provisional; Region: PRK11083 365046000162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046000163 active site 365046000164 phosphorylation site [posttranslational modification] 365046000165 intermolecular recognition site; other site 365046000166 dimerization interface [polypeptide binding]; other site 365046000167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046000168 DNA binding site [nucleotide binding] 365046000169 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 365046000170 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 365046000171 FMN binding site [chemical binding]; other site 365046000172 active site 365046000173 substrate binding site [chemical binding]; other site 365046000174 catalytic residue [active] 365046000175 glutathionine S-transferase; Provisional; Region: PRK10542 365046000176 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 365046000177 C-terminal domain interface [polypeptide binding]; other site 365046000178 GSH binding site (G-site) [chemical binding]; other site 365046000179 dimer interface [polypeptide binding]; other site 365046000180 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 365046000181 dimer interface [polypeptide binding]; other site 365046000182 N-terminal domain interface [polypeptide binding]; other site 365046000183 substrate binding pocket (H-site) [chemical binding]; other site 365046000184 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 365046000185 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 365046000186 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 365046000187 aldolase II superfamily protein; Provisional; Region: PRK07044 365046000188 intersubunit interface [polypeptide binding]; other site 365046000189 active site 365046000190 Zn2+ binding site [ion binding]; other site 365046000191 Flagellin N-methylase; Region: FliB; pfam03692 365046000192 Predicted flavoprotein [General function prediction only]; Region: COG0431 365046000193 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 365046000194 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 365046000195 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 365046000196 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 365046000197 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 365046000198 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 365046000199 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 365046000200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046000201 S-adenosylmethionine binding site [chemical binding]; other site 365046000202 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 365046000203 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 365046000204 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 365046000205 P-loop; other site 365046000206 Magnesium ion binding site [ion binding]; other site 365046000207 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 365046000208 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 365046000209 Magnesium ion binding site [ion binding]; other site 365046000210 Serine hydrolase; Region: Ser_hydrolase; pfam06821 365046000211 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046000212 ParB-like nuclease domain; Region: ParB; smart00470 365046000213 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 365046000214 short chain dehydrogenase; Provisional; Region: PRK06181 365046000215 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 365046000216 putative NAD(P) binding site [chemical binding]; other site 365046000217 active site 365046000218 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 365046000219 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 365046000220 dimerization interface [polypeptide binding]; other site 365046000221 NAD binding site [chemical binding]; other site 365046000222 ligand binding site [chemical binding]; other site 365046000223 catalytic site [active] 365046000224 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 365046000225 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046000226 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 365046000227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046000228 DNA-binding site [nucleotide binding]; DNA binding site 365046000229 FCD domain; Region: FCD; pfam07729 365046000230 BON domain; Region: BON; cl02771 365046000231 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 365046000232 FAD binding domain; Region: FAD_binding_4; pfam01565 365046000233 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 365046000234 EF-hand domain pair; Region: EF_hand_5; pfam13499 365046000235 Ca2+ binding site [ion binding]; other site 365046000236 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 365046000237 EF-hand domain pair; Region: EF_hand_5; pfam13499 365046000238 Ca2+ binding site [ion binding]; other site 365046000239 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 365046000240 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 365046000241 catalytic core [active] 365046000242 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046000243 CoenzymeA binding site [chemical binding]; other site 365046000244 subunit interaction site [polypeptide binding]; other site 365046000245 PHB binding site; other site 365046000246 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 365046000247 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 365046000248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046000249 Predicted transcriptional regulator [Transcription]; Region: COG1959 365046000250 Transcriptional regulator; Region: Rrf2; pfam02082 365046000251 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046000252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046000253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 365046000254 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 365046000255 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 365046000256 acyl-activating enzyme (AAE) consensus motif; other site 365046000257 putative AMP binding site [chemical binding]; other site 365046000258 putative active site [active] 365046000259 putative CoA binding site [chemical binding]; other site 365046000260 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 365046000261 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 365046000262 EamA-like transporter family; Region: EamA; pfam00892 365046000263 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 365046000264 EamA-like transporter family; Region: EamA; pfam00892 365046000265 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 365046000266 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 365046000267 substrate binding site [chemical binding]; other site 365046000268 catalytic Zn binding site [ion binding]; other site 365046000269 NAD binding site [chemical binding]; other site 365046000270 structural Zn binding site [ion binding]; other site 365046000271 dimer interface [polypeptide binding]; other site 365046000272 S-formylglutathione hydrolase; Region: PLN02442 365046000273 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 365046000274 DoxX; Region: DoxX; pfam07681 365046000275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 365046000276 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 365046000277 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 365046000278 NAD(P) binding site [chemical binding]; other site 365046000279 S-formylglutathione hydrolase; Region: PLN02442 365046000280 S-formylglutathione hydrolase; Region: PLN02442 365046000281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046000282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 365046000284 dimerization interface [polypeptide binding]; other site 365046000285 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046000286 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 365046000287 active site 365046000288 Zn binding site [ion binding]; other site 365046000289 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 365046000290 MarR family; Region: MarR_2; pfam12802 365046000291 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 365046000292 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 365046000293 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046000294 PGAP1-like protein; Region: PGAP1; pfam07819 365046000295 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 365046000296 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 365046000297 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046000298 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 365046000299 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 365046000300 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 365046000301 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 365046000302 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 365046000303 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 365046000304 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 365046000305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046000307 dimerization interface [polypeptide binding]; other site 365046000308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046000309 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 365046000310 Ligand Binding Site [chemical binding]; other site 365046000311 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 365046000312 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 365046000313 putative active site [active] 365046000314 putative metal binding site [ion binding]; other site 365046000315 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046000316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000317 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 365046000318 substrate binding pocket [chemical binding]; other site 365046000319 dimerization interface [polypeptide binding]; other site 365046000320 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 365046000321 active site 365046000322 substrate-binding site [chemical binding]; other site 365046000323 metal-binding site [ion binding] 365046000324 GTP binding site [chemical binding]; other site 365046000325 threonine dehydratase; Provisional; Region: PRK07334 365046000326 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 365046000327 tetramer interface [polypeptide binding]; other site 365046000328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046000329 catalytic residue [active] 365046000330 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 365046000331 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 365046000332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046000333 Walker A motif; other site 365046000334 ATP binding site [chemical binding]; other site 365046000335 Walker B motif; other site 365046000336 arginine finger; other site 365046000337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046000338 Walker A motif; other site 365046000339 ATP binding site [chemical binding]; other site 365046000340 Walker B motif; other site 365046000341 arginine finger; other site 365046000342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 365046000343 AAA domain; Region: AAA_33; pfam13671 365046000344 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 365046000345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046000346 ATP binding site [chemical binding]; other site 365046000347 putative Mg++ binding site [ion binding]; other site 365046000348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046000349 nucleotide binding region [chemical binding]; other site 365046000350 ATP-binding site [chemical binding]; other site 365046000351 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 365046000352 HRDC domain; Region: HRDC; pfam00570 365046000353 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 365046000354 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 365046000355 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 365046000356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 365046000357 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 365046000358 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 365046000359 Walker A/P-loop; other site 365046000360 ATP binding site [chemical binding]; other site 365046000361 Q-loop/lid; other site 365046000362 ABC transporter signature motif; other site 365046000363 Walker B; other site 365046000364 D-loop; other site 365046000365 H-loop/switch region; other site 365046000366 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 365046000367 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 365046000368 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 365046000369 substrate binding pocket [chemical binding]; other site 365046000370 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 365046000371 B12 binding site [chemical binding]; other site 365046000372 cobalt ligand [ion binding]; other site 365046000373 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 365046000374 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 365046000375 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 365046000376 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 365046000377 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 365046000378 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 365046000379 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 365046000380 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 365046000381 Nitrogen regulatory protein P-II; Region: P-II; smart00938 365046000382 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 365046000383 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 365046000384 active site 365046000385 Zn binding site [ion binding]; other site 365046000386 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 365046000387 active site 365046000388 homotetramer interface [polypeptide binding]; other site 365046000389 homodimer interface [polypeptide binding]; other site 365046000390 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046000391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046000392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046000394 dimerization interface [polypeptide binding]; other site 365046000395 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 365046000396 substrate binding pocket [chemical binding]; other site 365046000397 active site 365046000398 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 365046000399 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 365046000400 FAD binding domain; Region: FAD_binding_4; pfam01565 365046000401 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 365046000402 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 365046000403 Cysteine-rich domain; Region: CCG; pfam02754 365046000404 Cysteine-rich domain; Region: CCG; pfam02754 365046000405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 365046000406 Hemerythrin family; Region: Hemerythrin-like; cl15774 365046000407 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 365046000408 LytTr DNA-binding domain; Region: LytTR; smart00850 365046000409 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 365046000410 Acyltransferase family; Region: Acyl_transf_3; pfam01757 365046000411 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 365046000412 catalytic residues [active] 365046000413 dimer interface [polypeptide binding]; other site 365046000414 lysophospholipid transporter LplT; Provisional; Region: PRK11195 365046000415 alanine racemase; Reviewed; Region: dadX; PRK03646 365046000416 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 365046000417 active site 365046000418 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 365046000419 substrate binding site [chemical binding]; other site 365046000420 catalytic residues [active] 365046000421 dimer interface [polypeptide binding]; other site 365046000422 putative acetyltransferase; Provisional; Region: PRK03624 365046000423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046000424 Coenzyme A binding pocket [chemical binding]; other site 365046000425 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 365046000426 dimer interface [polypeptide binding]; other site 365046000427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046000428 ligand binding site [chemical binding]; other site 365046000429 CHASE domain; Region: CHASE; pfam03924 365046000430 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 365046000431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046000432 putative active site [active] 365046000433 heme pocket [chemical binding]; other site 365046000434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046000435 dimer interface [polypeptide binding]; other site 365046000436 phosphorylation site [posttranslational modification] 365046000437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046000438 ATP binding site [chemical binding]; other site 365046000439 Mg2+ binding site [ion binding]; other site 365046000440 G-X-G motif; other site 365046000441 Response regulator receiver domain; Region: Response_reg; pfam00072 365046000442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046000443 active site 365046000444 phosphorylation site [posttranslational modification] 365046000445 intermolecular recognition site; other site 365046000446 dimerization interface [polypeptide binding]; other site 365046000447 Response regulator receiver domain; Region: Response_reg; pfam00072 365046000448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046000449 active site 365046000450 phosphorylation site [posttranslational modification] 365046000451 intermolecular recognition site; other site 365046000452 dimerization interface [polypeptide binding]; other site 365046000453 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 365046000454 putative binding surface; other site 365046000455 active site 365046000456 HipA-like N-terminal domain; Region: HipA_N; pfam07805 365046000457 HipA-like C-terminal domain; Region: HipA_C; pfam07804 365046000458 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 365046000459 putative active site [active] 365046000460 homotetrameric interface [polypeptide binding]; other site 365046000461 metal binding site [ion binding]; metal-binding site 365046000462 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 365046000463 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 365046000464 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 365046000465 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 365046000466 aldolase II superfamily protein; Provisional; Region: PRK07044 365046000467 intersubunit interface [polypeptide binding]; other site 365046000468 active site 365046000469 Zn2+ binding site [ion binding]; other site 365046000470 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046000471 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 365046000472 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 365046000473 Dehydratase family; Region: ILVD_EDD; cl00340 365046000474 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 365046000475 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 365046000476 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 365046000477 putative substrate binding pocket [chemical binding]; other site 365046000478 trimer interface [polypeptide binding]; other site 365046000479 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 365046000480 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 365046000481 putative active site [active] 365046000482 putative metal binding site [ion binding]; other site 365046000483 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 365046000484 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 365046000485 NAD binding site [chemical binding]; other site 365046000486 catalytic residues [active] 365046000487 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 365046000488 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 365046000489 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 365046000490 MarR family; Region: MarR_2; cl17246 365046000491 Transcriptional regulators [Transcription]; Region: MarR; COG1846 365046000492 DNA repair protein RadA; Provisional; Region: PRK11823 365046000493 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 365046000494 Walker A motif/ATP binding site; other site 365046000495 ATP binding site [chemical binding]; other site 365046000496 Walker B motif; other site 365046000497 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 365046000498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 365046000499 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 365046000500 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 365046000501 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 365046000502 homodimer interface [polypeptide binding]; other site 365046000503 substrate-cofactor binding pocket; other site 365046000504 catalytic residue [active] 365046000505 Zinc-finger domain; Region: zf-CHCC; cl01821 365046000506 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 365046000507 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 365046000508 putative active site [active] 365046000509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046000510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000511 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 365046000512 putative dimerization interface [polypeptide binding]; other site 365046000513 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 365046000514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046000515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046000516 dimerization interface [polypeptide binding]; other site 365046000517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046000518 dimer interface [polypeptide binding]; other site 365046000519 phosphorylation site [posttranslational modification] 365046000520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046000521 ATP binding site [chemical binding]; other site 365046000522 Mg2+ binding site [ion binding]; other site 365046000523 G-X-G motif; other site 365046000524 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 365046000525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046000526 active site 365046000527 phosphorylation site [posttranslational modification] 365046000528 intermolecular recognition site; other site 365046000529 dimerization interface [polypeptide binding]; other site 365046000530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046000531 DNA binding site [nucleotide binding] 365046000532 muropeptide transporter; Validated; Region: ampG; cl17669 365046000533 Peptidase family M48; Region: Peptidase_M48; cl12018 365046000534 EamA-like transporter family; Region: EamA; pfam00892 365046000535 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 365046000536 active site 365046000537 dimer interface [polypeptide binding]; other site 365046000538 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 365046000539 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 365046000540 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 365046000541 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 365046000542 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 365046000543 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 365046000544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046000545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046000546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046000547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046000548 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 365046000549 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 365046000550 dimer interface [polypeptide binding]; other site 365046000551 ssDNA binding site [nucleotide binding]; other site 365046000552 tetramer (dimer of dimers) interface [polypeptide binding]; other site 365046000553 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 365046000554 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 365046000555 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 365046000556 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 365046000557 Ligand Binding Site [chemical binding]; other site 365046000558 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 365046000559 nudix motif; other site 365046000560 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 365046000561 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 365046000562 putative active site [active] 365046000563 putative metal binding site [ion binding]; other site 365046000564 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 365046000565 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 365046000566 ligand binding site [chemical binding]; other site 365046000567 homodimer interface [polypeptide binding]; other site 365046000568 NAD(P) binding site [chemical binding]; other site 365046000569 trimer interface B [polypeptide binding]; other site 365046000570 trimer interface A [polypeptide binding]; other site 365046000571 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 365046000572 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 365046000573 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 365046000574 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 365046000575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046000576 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 365046000577 acyl-activating enzyme (AAE) consensus motif; other site 365046000578 putative AMP binding site [chemical binding]; other site 365046000579 putative active site [active] 365046000580 putative CoA binding site [chemical binding]; other site 365046000581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046000582 S-adenosylmethionine binding site [chemical binding]; other site 365046000583 short chain dehydrogenase; Provisional; Region: PRK08303 365046000584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046000585 NAD(P) binding site [chemical binding]; other site 365046000586 active site 365046000587 Helix-turn-helix domain; Region: HTH_18; pfam12833 365046000588 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 365046000589 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 365046000590 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 365046000591 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 365046000592 Cl binding site [ion binding]; other site 365046000593 oligomer interface [polypeptide binding]; other site 365046000594 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 365046000595 active site 365046000596 nucleophile elbow; other site 365046000597 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 365046000598 Isochorismatase family; Region: Isochorismatase; pfam00857 365046000599 catalytic triad [active] 365046000600 conserved cis-peptide bond; other site 365046000601 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 365046000602 30S subunit binding site; other site 365046000603 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 365046000604 active site 365046000605 phosphorylation site [posttranslational modification] 365046000606 HPr kinase/phosphorylase; Provisional; Region: PRK05428 365046000607 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 365046000608 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 365046000609 Hpr binding site; other site 365046000610 active site 365046000611 homohexamer subunit interaction site [polypeptide binding]; other site 365046000612 ferric uptake regulator; Provisional; Region: fur; PRK09462 365046000613 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 365046000614 metal binding site 2 [ion binding]; metal-binding site 365046000615 putative DNA binding helix; other site 365046000616 metal binding site 1 [ion binding]; metal-binding site 365046000617 dimer interface [polypeptide binding]; other site 365046000618 structural Zn2+ binding site [ion binding]; other site 365046000619 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 365046000620 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 365046000621 dihydrodipicolinate reductase; Provisional; Region: PRK00048 365046000622 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 365046000623 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 365046000624 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 365046000625 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 365046000626 TolR protein; Region: tolR; TIGR02801 365046000627 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 365046000628 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 365046000629 HIGH motif; other site 365046000630 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 365046000631 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 365046000632 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 365046000633 active site 365046000634 KMSKS motif; other site 365046000635 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 365046000636 tRNA binding surface [nucleotide binding]; other site 365046000637 Lipopolysaccharide-assembly; Region: LptE; cl01125 365046000638 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 365046000639 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 365046000640 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046000641 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 365046000642 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 365046000643 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 365046000644 homotrimer interaction site [polypeptide binding]; other site 365046000645 putative active site [active] 365046000646 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 365046000647 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 365046000648 putative catalytic cysteine [active] 365046000649 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 365046000650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046000651 sequence-specific DNA binding site [nucleotide binding]; other site 365046000652 salt bridge; other site 365046000653 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 365046000654 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 365046000655 Glutamate-cysteine ligase; Region: GshA; pfam08886 365046000656 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 365046000657 potassium uptake protein; Region: kup; TIGR00794 365046000658 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 365046000659 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 365046000660 C-terminal domain interface [polypeptide binding]; other site 365046000661 GSH binding site (G-site) [chemical binding]; other site 365046000662 dimer interface [polypeptide binding]; other site 365046000663 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 365046000664 dimer interface [polypeptide binding]; other site 365046000665 N-terminal domain interface [polypeptide binding]; other site 365046000666 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 365046000667 glutathione synthetase; Provisional; Region: PRK05246 365046000668 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 365046000669 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 365046000670 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 365046000671 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 365046000672 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 365046000673 putative active site [active] 365046000674 putative dimer interface [polypeptide binding]; other site 365046000675 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 365046000676 methionine synthase; Provisional; Region: PRK01207 365046000677 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 365046000678 substrate binding site [chemical binding]; other site 365046000679 THF binding site; other site 365046000680 zinc-binding site [ion binding]; other site 365046000681 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 365046000682 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 365046000683 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 365046000684 putative NAD(P) binding site [chemical binding]; other site 365046000685 putative substrate binding site [chemical binding]; other site 365046000686 catalytic Zn binding site [ion binding]; other site 365046000687 structural Zn binding site [ion binding]; other site 365046000688 dimer interface [polypeptide binding]; other site 365046000689 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046000690 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 365046000691 acyl carrier protein; Provisional; Region: PRK09184 365046000692 Predicted membrane protein [Function unknown]; Region: COG4648 365046000693 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 365046000694 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046000695 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046000696 acyl-activating enzyme (AAE) consensus motif; other site 365046000697 acyl-activating enzyme (AAE) consensus motif; other site 365046000698 AMP binding site [chemical binding]; other site 365046000699 active site 365046000700 CoA binding site [chemical binding]; other site 365046000701 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 365046000702 active site 2 [active] 365046000703 dimer interface [polypeptide binding]; other site 365046000704 active site 1 [active] 365046000705 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 365046000706 putative acyl-acceptor binding pocket; other site 365046000707 Predicted exporter [General function prediction only]; Region: COG4258 365046000708 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 365046000709 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 365046000710 NodB motif; other site 365046000711 active site 365046000712 catalytic site [active] 365046000713 metal binding site [ion binding]; metal-binding site 365046000714 Methyltransferase domain; Region: Methyltransf_12; pfam08242 365046000715 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 365046000716 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 365046000717 dimer interface [polypeptide binding]; other site 365046000718 active site 365046000719 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 365046000720 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 365046000721 active site 2 [active] 365046000722 active site 1 [active] 365046000723 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 365046000724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046000725 NAD(P) binding site [chemical binding]; other site 365046000726 active site 365046000727 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 365046000728 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 365046000729 Putative Catalytic site; other site 365046000730 DXD motif; other site 365046000731 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 365046000732 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 365046000733 putative acyl-acceptor binding pocket; other site 365046000734 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 365046000735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 365046000736 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 365046000737 active site 365046000738 Amidohydrolase; Region: Amidohydro_2; pfam04909 365046000739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046000740 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046000741 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046000742 LysE type translocator; Region: LysE; cl00565 365046000743 LysE type translocator; Region: LysE; cl00565 365046000744 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 365046000745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046000747 dimerization interface [polypeptide binding]; other site 365046000748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000749 transcriptional activator TtdR; Provisional; Region: PRK09801 365046000750 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 365046000751 putative effector binding pocket; other site 365046000752 dimerization interface [polypeptide binding]; other site 365046000753 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 365046000754 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 365046000755 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 365046000756 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 365046000757 active site 365046000758 HIGH motif; other site 365046000759 KMSK motif region; other site 365046000760 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 365046000761 tRNA binding surface [nucleotide binding]; other site 365046000762 anticodon binding site; other site 365046000763 Sporulation related domain; Region: SPOR; pfam05036 365046000764 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 365046000765 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 365046000766 catalytic residues [active] 365046000767 hinge region; other site 365046000768 alpha helical domain; other site 365046000769 OstA-like protein; Region: OstA; pfam03968 365046000770 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 365046000771 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 365046000772 Walker A/P-loop; other site 365046000773 ATP binding site [chemical binding]; other site 365046000774 Q-loop/lid; other site 365046000775 ABC transporter signature motif; other site 365046000776 Walker B; other site 365046000777 D-loop; other site 365046000778 H-loop/switch region; other site 365046000779 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 365046000780 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 365046000781 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 365046000782 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 365046000783 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 365046000784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 365046000785 PIN domain; Region: PIN_3; cl17397 365046000786 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 365046000787 SEC-C motif; Region: SEC-C; pfam02810 365046000788 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 365046000789 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 365046000790 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 365046000791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046000792 non-specific DNA binding site [nucleotide binding]; other site 365046000793 salt bridge; other site 365046000794 sequence-specific DNA binding site [nucleotide binding]; other site 365046000795 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 365046000796 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 365046000797 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 365046000798 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 365046000799 hypothetical protein; Provisional; Region: PRK10621 365046000800 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 365046000801 choline dehydrogenase; Validated; Region: PRK02106 365046000802 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 365046000803 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 365046000804 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 365046000805 tetrameric interface [polypeptide binding]; other site 365046000806 NAD binding site [chemical binding]; other site 365046000807 catalytic residues [active] 365046000808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046000809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000810 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 365046000811 putative effector binding pocket; other site 365046000812 dimerization interface [polypeptide binding]; other site 365046000813 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 365046000814 Permease; Region: Permease; pfam02405 365046000815 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 365046000816 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 365046000817 Walker A/P-loop; other site 365046000818 ATP binding site [chemical binding]; other site 365046000819 Q-loop/lid; other site 365046000820 ABC transporter signature motif; other site 365046000821 Walker B; other site 365046000822 D-loop; other site 365046000823 H-loop/switch region; other site 365046000824 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 365046000825 mce related protein; Region: MCE; pfam02470 365046000826 Protein of unknown function (DUF330); Region: DUF330; pfam03886 365046000827 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 365046000828 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 365046000829 ligand binding site [chemical binding]; other site 365046000830 flexible hinge region; other site 365046000831 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 365046000832 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 365046000833 putative active site [active] 365046000834 putative catalytic site [active] 365046000835 short chain dehydrogenase; Provisional; Region: PRK06123 365046000836 classical (c) SDRs; Region: SDR_c; cd05233 365046000837 NAD(P) binding site [chemical binding]; other site 365046000838 active site 365046000839 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 365046000840 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 365046000841 putative catalytic residue [active] 365046000842 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 365046000843 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046000844 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 365046000845 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 365046000846 C-terminal domain interface [polypeptide binding]; other site 365046000847 GSH binding site (G-site) [chemical binding]; other site 365046000848 dimer interface [polypeptide binding]; other site 365046000849 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 365046000850 dimer interface [polypeptide binding]; other site 365046000851 N-terminal domain interface [polypeptide binding]; other site 365046000852 substrate binding pocket (H-site) [chemical binding]; other site 365046000853 Protein of unknown function DUF72; Region: DUF72; pfam01904 365046000854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046000855 LysR family transcriptional regulator; Provisional; Region: PRK14997 365046000856 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 365046000857 putative effector binding pocket; other site 365046000858 dimerization interface [polypeptide binding]; other site 365046000859 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 365046000860 oligomer interface [polypeptide binding]; other site 365046000861 metal binding site [ion binding]; metal-binding site 365046000862 metal binding site [ion binding]; metal-binding site 365046000863 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 365046000864 putative Cl binding site [ion binding]; other site 365046000865 aspartate ring; other site 365046000866 basic sphincter; other site 365046000867 hydrophobic gate; other site 365046000868 periplasmic entrance; other site 365046000869 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 365046000870 dimer interface [polypeptide binding]; other site 365046000871 active site 365046000872 aspartate-rich active site metal binding site; other site 365046000873 allosteric magnesium binding site [ion binding]; other site 365046000874 Schiff base residues; other site 365046000875 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 365046000876 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 365046000877 dimer interface [polypeptide binding]; other site 365046000878 [2Fe-2S] cluster binding site [ion binding]; other site 365046000879 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 365046000880 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 365046000881 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 365046000882 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 365046000883 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 365046000884 S17 interaction site [polypeptide binding]; other site 365046000885 S8 interaction site; other site 365046000886 16S rRNA interaction site [nucleotide binding]; other site 365046000887 streptomycin interaction site [chemical binding]; other site 365046000888 23S rRNA interaction site [nucleotide binding]; other site 365046000889 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 365046000890 30S ribosomal protein S7; Validated; Region: PRK05302 365046000891 elongation factor G; Reviewed; Region: PRK00007 365046000892 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 365046000893 G1 box; other site 365046000894 putative GEF interaction site [polypeptide binding]; other site 365046000895 GTP/Mg2+ binding site [chemical binding]; other site 365046000896 Switch I region; other site 365046000897 G2 box; other site 365046000898 G3 box; other site 365046000899 Switch II region; other site 365046000900 G4 box; other site 365046000901 G5 box; other site 365046000902 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 365046000903 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 365046000904 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 365046000905 elongation factor Tu; Reviewed; Region: PRK00049 365046000906 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 365046000907 G1 box; other site 365046000908 GEF interaction site [polypeptide binding]; other site 365046000909 GTP/Mg2+ binding site [chemical binding]; other site 365046000910 Switch I region; other site 365046000911 G2 box; other site 365046000912 G3 box; other site 365046000913 Switch II region; other site 365046000914 G4 box; other site 365046000915 G5 box; other site 365046000916 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 365046000917 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 365046000918 Antibiotic Binding Site [chemical binding]; other site 365046000919 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 365046000920 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 365046000921 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 365046000922 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 365046000923 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 365046000924 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 365046000925 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 365046000926 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 365046000927 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 365046000928 putative translocon binding site; other site 365046000929 protein-rRNA interface [nucleotide binding]; other site 365046000930 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 365046000931 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 365046000932 G-X-X-G motif; other site 365046000933 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 365046000934 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 365046000935 23S rRNA interface [nucleotide binding]; other site 365046000936 5S rRNA interface [nucleotide binding]; other site 365046000937 putative antibiotic binding site [chemical binding]; other site 365046000938 L25 interface [polypeptide binding]; other site 365046000939 L27 interface [polypeptide binding]; other site 365046000940 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 365046000941 23S rRNA interface [nucleotide binding]; other site 365046000942 putative translocon interaction site; other site 365046000943 signal recognition particle (SRP54) interaction site; other site 365046000944 L23 interface [polypeptide binding]; other site 365046000945 trigger factor interaction site; other site 365046000946 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 365046000947 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 365046000948 catalytic triad [active] 365046000949 dimer interface [polypeptide binding]; other site 365046000950 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 365046000951 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 365046000952 Cytochrome C' Region: Cytochrom_C_2; pfam01322 365046000953 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 365046000954 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 365046000955 catalytic residues [active] 365046000956 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 365046000957 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 365046000958 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046000959 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046000960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046000961 putative substrate translocation pore; other site 365046000962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046000963 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 365046000964 active pocket/dimerization site; other site 365046000965 active site 365046000966 phosphorylation site [posttranslational modification] 365046000967 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 365046000968 dimerization domain swap beta strand [polypeptide binding]; other site 365046000969 regulatory protein interface [polypeptide binding]; other site 365046000970 active site 365046000971 regulatory phosphorylation site [posttranslational modification]; other site 365046000972 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 365046000973 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 365046000974 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 365046000975 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 365046000976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 365046000977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046000978 ATP binding site [chemical binding]; other site 365046000979 Mg2+ binding site [ion binding]; other site 365046000980 G-X-G motif; other site 365046000981 EamA-like transporter family; Region: EamA; pfam00892 365046000982 lipoyl synthase; Provisional; Region: PRK05481 365046000983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 365046000984 FeS/SAM binding site; other site 365046000985 Calicivirus coat protein C-terminal; Region: Calici_coat_C; pfam08435 365046000986 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 365046000987 Protein of unknown function (DUF493); Region: DUF493; cl01102 365046000988 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 365046000989 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 365046000990 homodimer interface [polypeptide binding]; other site 365046000991 substrate-cofactor binding pocket; other site 365046000992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046000993 catalytic residue [active] 365046000994 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 365046000995 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 365046000996 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 365046000997 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 365046000998 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 365046000999 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 365046001000 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 365046001001 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 365046001002 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 365046001003 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 365046001004 beta subunit interaction interface [polypeptide binding]; other site 365046001005 Walker A motif; other site 365046001006 ATP binding site [chemical binding]; other site 365046001007 Walker B motif; other site 365046001008 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 365046001009 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 365046001010 core domain interface [polypeptide binding]; other site 365046001011 delta subunit interface [polypeptide binding]; other site 365046001012 epsilon subunit interface [polypeptide binding]; other site 365046001013 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 365046001014 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 365046001015 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 365046001016 alpha subunit interaction interface [polypeptide binding]; other site 365046001017 Walker A motif; other site 365046001018 ATP binding site [chemical binding]; other site 365046001019 Walker B motif; other site 365046001020 inhibitor binding site; inhibition site 365046001021 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 365046001022 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 365046001023 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 365046001024 gamma subunit interface [polypeptide binding]; other site 365046001025 epsilon subunit interface [polypeptide binding]; other site 365046001026 LBP interface [polypeptide binding]; other site 365046001027 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 365046001028 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 365046001029 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 365046001030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046001031 putative substrate translocation pore; other site 365046001032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046001033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046001034 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 365046001035 putative effector binding pocket; other site 365046001036 putative dimerization interface [polypeptide binding]; other site 365046001037 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 365046001038 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 365046001039 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046001040 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 365046001041 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 365046001042 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 365046001043 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046001044 catalytic loop [active] 365046001045 iron binding site [ion binding]; other site 365046001046 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 365046001047 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 365046001048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 365046001049 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 365046001050 H+ Antiporter protein; Region: 2A0121; TIGR00900 365046001051 Repair protein; Region: Repair_PSII; cl01535 365046001052 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 365046001053 Repair protein; Region: Repair_PSII; pfam04536 365046001054 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 365046001055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046001056 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 365046001057 SnoaL-like domain; Region: SnoaL_3; pfam13474 365046001058 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 365046001059 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 365046001060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 365046001061 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 365046001062 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 365046001063 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 365046001064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 365046001065 rod shape-determining protein MreD; Region: MreD; cl01087 365046001066 rod shape-determining protein MreC; Provisional; Region: PRK13922 365046001067 rod shape-determining protein MreC; Region: MreC; pfam04085 365046001068 rod shape-determining protein MreB; Provisional; Region: PRK13927 365046001069 MreB and similar proteins; Region: MreB_like; cd10225 365046001070 nucleotide binding site [chemical binding]; other site 365046001071 Mg binding site [ion binding]; other site 365046001072 putative protofilament interaction site [polypeptide binding]; other site 365046001073 RodZ interaction site [polypeptide binding]; other site 365046001074 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 365046001075 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 365046001076 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 365046001077 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 365046001078 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 365046001079 GatB domain; Region: GatB_Yqey; smart00845 365046001080 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 365046001081 active site 365046001082 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 365046001083 putative active site [active] 365046001084 putative catalytic site [active] 365046001085 putative DNA binding site [nucleotide binding]; other site 365046001086 putative phosphate binding site [ion binding]; other site 365046001087 metal binding site A [ion binding]; metal-binding site 365046001088 putative AP binding site [nucleotide binding]; other site 365046001089 putative metal binding site B [ion binding]; other site 365046001090 hypothetical protein; Provisional; Region: PRK11622 365046001091 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 365046001092 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 365046001093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046001094 dimer interface [polypeptide binding]; other site 365046001095 conserved gate region; other site 365046001096 putative PBP binding loops; other site 365046001097 ABC-ATPase subunit interface; other site 365046001098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046001099 Walker A/P-loop; other site 365046001100 ATP binding site [chemical binding]; other site 365046001101 ABC transporter; Region: ABC_tran; pfam00005 365046001102 Q-loop/lid; other site 365046001103 ABC transporter signature motif; other site 365046001104 Walker B; other site 365046001105 D-loop; other site 365046001106 H-loop/switch region; other site 365046001107 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 365046001108 active site 365046001109 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 365046001110 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 365046001111 Probable Catalytic site; other site 365046001112 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 365046001113 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 365046001114 Cupin; Region: Cupin_6; pfam12852 365046001115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046001116 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 365046001117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046001118 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 365046001119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046001120 motif II; other site 365046001121 Uncharacterized conserved protein [Function unknown]; Region: COG0398 365046001122 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 365046001123 mercuric reductase; Validated; Region: PRK06370 365046001124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046001125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046001126 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 365046001127 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 365046001128 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 365046001129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046001130 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 365046001131 NIPSNAP; Region: NIPSNAP; pfam07978 365046001132 Predicted transcriptional regulator [Transcription]; Region: COG2378 365046001133 HTH domain; Region: HTH_11; pfam08279 365046001134 WYL domain; Region: WYL; pfam13280 365046001135 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 365046001136 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 365046001137 Phospholipase A1; Region: PLA1; pfam02253 365046001138 substrate binding site [chemical binding]; other site 365046001139 dimerization interface [polypeptide binding]; other site 365046001140 active site 365046001141 calcium binding site [ion binding]; other site 365046001142 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 365046001143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 365046001144 substrate binding pocket [chemical binding]; other site 365046001145 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 365046001146 Part of AAA domain; Region: AAA_19; pfam13245 365046001147 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 365046001148 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 365046001149 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 365046001150 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 365046001151 dimer interface [polypeptide binding]; other site 365046001152 active site 365046001153 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 365046001154 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 365046001155 dimer interface [polypeptide binding]; other site 365046001156 active site 365046001157 heme binding site [chemical binding]; other site 365046001158 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 365046001159 Predicted permeases [General function prediction only]; Region: COG0679 365046001160 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 365046001161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046001162 NAD(P) binding site [chemical binding]; other site 365046001163 active site 365046001164 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 365046001165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046001166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 365046001167 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 365046001168 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 365046001169 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046001170 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 365046001171 acyl-activating enzyme (AAE) consensus motif; other site 365046001172 putative AMP binding site [chemical binding]; other site 365046001173 putative active site [active] 365046001174 acyl-activating enzyme (AAE) consensus motif; other site 365046001175 putative CoA binding site [chemical binding]; other site 365046001176 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046001177 GAF domain; Region: GAF; pfam01590 365046001178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046001179 putative active site [active] 365046001180 PAS fold; Region: PAS_3; pfam08447 365046001181 heme pocket [chemical binding]; other site 365046001182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 365046001183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046001184 dimer interface [polypeptide binding]; other site 365046001185 phosphorylation site [posttranslational modification] 365046001186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046001187 ATP binding site [chemical binding]; other site 365046001188 Mg2+ binding site [ion binding]; other site 365046001189 G-X-G motif; other site 365046001190 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046001191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046001192 active site 365046001193 phosphorylation site [posttranslational modification] 365046001194 intermolecular recognition site; other site 365046001195 dimerization interface [polypeptide binding]; other site 365046001196 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046001197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046001198 active site 365046001199 phosphorylation site [posttranslational modification] 365046001200 intermolecular recognition site; other site 365046001201 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 365046001202 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046001203 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046001204 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 365046001205 DctM-like transporters; Region: DctM; pfam06808 365046001206 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 365046001207 L-asparaginase II; Region: Asparaginase_II; pfam06089 365046001208 Protein of unknown function, DUF486; Region: DUF486; cl01236 365046001209 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 365046001210 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 365046001211 NAD binding site [chemical binding]; other site 365046001212 catalytic Zn binding site [ion binding]; other site 365046001213 structural Zn binding site [ion binding]; other site 365046001214 Arginase family; Region: Arginase; cd09989 365046001215 agmatinase; Region: agmatinase; TIGR01230 365046001216 active site 365046001217 Mn binding site [ion binding]; other site 365046001218 oligomer interface [polypeptide binding]; other site 365046001219 circadian clock protein KaiC; Reviewed; Region: PRK09302 365046001220 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 365046001221 Walker A motif; other site 365046001222 ATP binding site [chemical binding]; other site 365046001223 Walker B motif; other site 365046001224 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 365046001225 Walker A motif; other site 365046001226 ATP binding site [chemical binding]; other site 365046001227 Walker B motif; other site 365046001228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046001229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046001230 dimer interface [polypeptide binding]; other site 365046001231 phosphorylation site [posttranslational modification] 365046001232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046001233 ATP binding site [chemical binding]; other site 365046001234 Mg2+ binding site [ion binding]; other site 365046001235 G-X-G motif; other site 365046001236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046001237 Response regulator receiver domain; Region: Response_reg; pfam00072 365046001238 active site 365046001239 phosphorylation site [posttranslational modification] 365046001240 intermolecular recognition site; other site 365046001241 dimerization interface [polypeptide binding]; other site 365046001242 PAS domain S-box; Region: sensory_box; TIGR00229 365046001243 PAS domain; Region: PAS; smart00091 365046001244 putative active site [active] 365046001245 heme pocket [chemical binding]; other site 365046001246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046001247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046001248 dimer interface [polypeptide binding]; other site 365046001249 phosphorylation site [posttranslational modification] 365046001250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046001251 ATP binding site [chemical binding]; other site 365046001252 Mg2+ binding site [ion binding]; other site 365046001253 G-X-G motif; other site 365046001254 Response regulator receiver domain; Region: Response_reg; pfam00072 365046001255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046001256 active site 365046001257 phosphorylation site [posttranslational modification] 365046001258 intermolecular recognition site; other site 365046001259 dimerization interface [polypeptide binding]; other site 365046001260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046001261 PAS fold; Region: PAS_3; pfam08447 365046001262 putative active site [active] 365046001263 heme pocket [chemical binding]; other site 365046001264 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046001265 GAF domain; Region: GAF; pfam01590 365046001266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046001267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046001268 dimer interface [polypeptide binding]; other site 365046001269 phosphorylation site [posttranslational modification] 365046001270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046001271 ATP binding site [chemical binding]; other site 365046001272 Mg2+ binding site [ion binding]; other site 365046001273 G-X-G motif; other site 365046001274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046001275 Response regulator receiver domain; Region: Response_reg; pfam00072 365046001276 active site 365046001277 phosphorylation site [posttranslational modification] 365046001278 intermolecular recognition site; other site 365046001279 dimerization interface [polypeptide binding]; other site 365046001280 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 365046001281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046001282 ATP binding site [chemical binding]; other site 365046001283 putative Mg++ binding site [ion binding]; other site 365046001284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046001285 nucleotide binding region [chemical binding]; other site 365046001286 ATP-binding site [chemical binding]; other site 365046001287 CheB methylesterase; Region: CheB_methylest; pfam01339 365046001288 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 365046001289 CheB methylesterase; Region: CheB_methylest; pfam01339 365046001290 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 365046001291 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 365046001292 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 365046001293 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 365046001294 PAS domain; Region: PAS_10; pfam13596 365046001295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046001296 putative active site [active] 365046001297 heme pocket [chemical binding]; other site 365046001298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046001299 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 365046001300 putative active site [active] 365046001301 heme pocket [chemical binding]; other site 365046001302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046001303 putative active site [active] 365046001304 heme pocket [chemical binding]; other site 365046001305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046001306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046001307 dimer interface [polypeptide binding]; other site 365046001308 phosphorylation site [posttranslational modification] 365046001309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046001310 ATP binding site [chemical binding]; other site 365046001311 Mg2+ binding site [ion binding]; other site 365046001312 G-X-G motif; other site 365046001313 Response regulator receiver domain; Region: Response_reg; pfam00072 365046001314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046001315 active site 365046001316 phosphorylation site [posttranslational modification] 365046001317 intermolecular recognition site; other site 365046001318 dimerization interface [polypeptide binding]; other site 365046001319 Uncharacterized conserved protein [Function unknown]; Region: COG2155 365046001320 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 365046001321 active site 365046001322 catalytic triad [active] 365046001323 oxyanion hole [active] 365046001324 Proline dehydrogenase; Region: Pro_dh; cl03282 365046001325 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 365046001326 NAD(P) binding site [chemical binding]; other site 365046001327 catalytic residues [active] 365046001328 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 365046001329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046001330 putative DNA binding site [nucleotide binding]; other site 365046001331 putative Zn2+ binding site [ion binding]; other site 365046001332 AsnC family; Region: AsnC_trans_reg; pfam01037 365046001333 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 365046001334 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 365046001335 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 365046001336 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 365046001337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 365046001338 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 365046001339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046001340 dimer interface [polypeptide binding]; other site 365046001341 conserved gate region; other site 365046001342 putative PBP binding loops; other site 365046001343 ABC-ATPase subunit interface; other site 365046001344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046001345 putative PBP binding loops; other site 365046001346 dimer interface [polypeptide binding]; other site 365046001347 ABC-ATPase subunit interface; other site 365046001348 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 365046001349 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 365046001350 Walker A/P-loop; other site 365046001351 ATP binding site [chemical binding]; other site 365046001352 Q-loop/lid; other site 365046001353 ABC transporter signature motif; other site 365046001354 Walker B; other site 365046001355 D-loop; other site 365046001356 H-loop/switch region; other site 365046001357 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 365046001358 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 365046001359 Walker A/P-loop; other site 365046001360 ATP binding site [chemical binding]; other site 365046001361 Q-loop/lid; other site 365046001362 ABC transporter signature motif; other site 365046001363 Walker B; other site 365046001364 D-loop; other site 365046001365 H-loop/switch region; other site 365046001366 TOBE domain; Region: TOBE_2; pfam08402 365046001367 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 365046001368 Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; Region: ALBUMIN; cl00031 365046001369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046001370 putative DNA binding site [nucleotide binding]; other site 365046001371 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 365046001372 putative Zn2+ binding site [ion binding]; other site 365046001373 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 365046001374 glycerol kinase; Provisional; Region: glpK; PRK00047 365046001375 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 365046001376 N- and C-terminal domain interface [polypeptide binding]; other site 365046001377 active site 365046001378 MgATP binding site [chemical binding]; other site 365046001379 catalytic site [active] 365046001380 metal binding site [ion binding]; metal-binding site 365046001381 glycerol binding site [chemical binding]; other site 365046001382 homotetramer interface [polypeptide binding]; other site 365046001383 homodimer interface [polypeptide binding]; other site 365046001384 FBP binding site [chemical binding]; other site 365046001385 protein IIAGlc interface [polypeptide binding]; other site 365046001386 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 365046001387 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 365046001388 short chain dehydrogenase; Provisional; Region: PRK06500 365046001389 classical (c) SDRs; Region: SDR_c; cd05233 365046001390 NAD(P) binding site [chemical binding]; other site 365046001391 active site 365046001392 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 365046001393 NlpC/P60 family; Region: NLPC_P60; pfam00877 365046001394 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 365046001395 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 365046001396 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 365046001397 Kelch motif; Region: Kelch_1; pfam01344 365046001398 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 365046001399 Kelch motif; Region: Kelch_6; pfam13964 365046001400 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 365046001401 Kelch motif; Region: Kelch_1; pfam01344 365046001402 Galactose oxidase, central domain; Region: Kelch_3; cl02701 365046001403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046001404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046001405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046001406 dimerization interface [polypeptide binding]; other site 365046001407 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 365046001408 Transcriptional regulators [Transcription]; Region: MarR; COG1846 365046001409 MarR family; Region: MarR_2; pfam12802 365046001410 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 365046001411 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046001412 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 365046001413 dimer interface [polypeptide binding]; other site 365046001414 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 365046001415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046001416 S-adenosylmethionine binding site [chemical binding]; other site 365046001417 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 365046001418 ATP binding site [chemical binding]; other site 365046001419 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 365046001420 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 365046001421 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 365046001422 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 365046001423 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 365046001424 rRNA binding site [nucleotide binding]; other site 365046001425 predicted 30S ribosome binding site; other site 365046001426 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 365046001427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 365046001428 catalytic residue [active] 365046001429 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 365046001430 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 365046001431 Walker A motif; other site 365046001432 ATP binding site [chemical binding]; other site 365046001433 Walker B motif; other site 365046001434 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 365046001435 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 365046001436 Walker A motif; other site 365046001437 ATP binding site [chemical binding]; other site 365046001438 Walker B motif; other site 365046001439 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 365046001440 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 365046001441 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 365046001442 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046001443 catalytic loop [active] 365046001444 iron binding site [ion binding]; other site 365046001445 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 365046001446 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 365046001447 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 365046001448 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 365046001449 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 365046001450 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046001451 BON domain; Region: BON; pfam04972 365046001452 BON domain; Region: BON; pfam04972 365046001453 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 365046001454 dimer interface [polypeptide binding]; other site 365046001455 active site 365046001456 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 365046001457 Fatty acid desaturase; Region: FA_desaturase; pfam00487 365046001458 Di-iron ligands [ion binding]; other site 365046001459 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 365046001460 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 365046001461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046001462 S-adenosylmethionine binding site [chemical binding]; other site 365046001463 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 365046001464 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 365046001465 active site 365046001466 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046001467 CoenzymeA binding site [chemical binding]; other site 365046001468 subunit interaction site [polypeptide binding]; other site 365046001469 PHB binding site; other site 365046001470 acyl-CoA synthetase; Validated; Region: PRK05850 365046001471 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 365046001472 acyl-activating enzyme (AAE) consensus motif; other site 365046001473 active site 365046001474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046001475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046001476 active site 365046001477 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046001478 TAP-like protein; Region: Abhydrolase_4; pfam08386 365046001479 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 365046001480 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 365046001481 active site 365046001482 Family description; Region: VCBS; pfam13517 365046001483 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 365046001484 tocopherol O-methyltransferase; Region: PLN02244 365046001485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046001486 S-adenosylmethionine binding site [chemical binding]; other site 365046001487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046001488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 365046001489 NAD(P) binding site [chemical binding]; other site 365046001490 active site 365046001491 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 365046001492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046001493 AMP binding site [chemical binding]; other site 365046001494 active site 365046001495 acyl-activating enzyme (AAE) consensus motif; other site 365046001496 CoA binding site [chemical binding]; other site 365046001497 Phosphopantetheine attachment site; Region: PP-binding; cl09936 365046001498 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 365046001499 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 365046001500 Predicted methyltransferases [General function prediction only]; Region: COG0313 365046001501 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 365046001502 putative SAM binding site [chemical binding]; other site 365046001503 putative homodimer interface [polypeptide binding]; other site 365046001504 primosome assembly protein PriA; Validated; Region: PRK05580 365046001505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046001506 ATP binding site [chemical binding]; other site 365046001507 putative Mg++ binding site [ion binding]; other site 365046001508 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 365046001509 substrate binding site [chemical binding]; other site 365046001510 active site 365046001511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 365046001512 binding surface 365046001513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 365046001514 binding surface 365046001515 TPR motif; other site 365046001516 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 365046001517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046001518 S-adenosylmethionine binding site [chemical binding]; other site 365046001519 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 365046001520 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 365046001521 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 365046001522 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 365046001523 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 365046001524 nucleotide binding site/active site [active] 365046001525 HIT family signature motif; other site 365046001526 catalytic residue [active] 365046001527 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 365046001528 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 365046001529 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 365046001530 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 365046001531 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 365046001532 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 365046001533 NADP binding site [chemical binding]; other site 365046001534 active site 365046001535 putative substrate binding site [chemical binding]; other site 365046001536 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 365046001537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 365046001538 UDP-galactopyranose mutase; Region: GLF; pfam03275 365046001539 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 365046001540 putative catalytic residue [active] 365046001541 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 365046001542 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 365046001543 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 365046001544 DsbD alpha interface [polypeptide binding]; other site 365046001545 catalytic residues [active] 365046001546 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 365046001547 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 365046001548 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 365046001549 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 365046001550 FtsH Extracellular; Region: FtsH_ext; pfam06480 365046001551 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 365046001552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046001553 Walker A motif; other site 365046001554 ATP binding site [chemical binding]; other site 365046001555 Walker B motif; other site 365046001556 arginine finger; other site 365046001557 Peptidase family M41; Region: Peptidase_M41; pfam01434 365046001558 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 365046001559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046001560 putative DNA binding site [nucleotide binding]; other site 365046001561 putative Zn2+ binding site [ion binding]; other site 365046001562 AsnC family; Region: AsnC_trans_reg; pfam01037 365046001563 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 365046001564 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 365046001565 dimer interface [polypeptide binding]; other site 365046001566 TPP-binding site [chemical binding]; other site 365046001567 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 365046001568 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 365046001569 Transcriptional regulators [Transcription]; Region: PurR; COG1609 365046001570 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 365046001571 DNA binding site [nucleotide binding] 365046001572 domain linker motif; other site 365046001573 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 365046001574 putative dimerization interface [polypeptide binding]; other site 365046001575 putative ligand binding site [chemical binding]; other site 365046001576 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 365046001577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046001578 dimer interface [polypeptide binding]; other site 365046001579 conserved gate region; other site 365046001580 putative PBP binding loops; other site 365046001581 ABC-ATPase subunit interface; other site 365046001582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046001583 dimer interface [polypeptide binding]; other site 365046001584 conserved gate region; other site 365046001585 putative PBP binding loops; other site 365046001586 ABC-ATPase subunit interface; other site 365046001587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 365046001588 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 365046001589 substrate binding pocket [chemical binding]; other site 365046001590 membrane-bound complex binding site; other site 365046001591 hinge residues; other site 365046001592 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 365046001593 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 365046001594 Walker A/P-loop; other site 365046001595 ATP binding site [chemical binding]; other site 365046001596 Q-loop/lid; other site 365046001597 ABC transporter signature motif; other site 365046001598 Walker B; other site 365046001599 D-loop; other site 365046001600 H-loop/switch region; other site 365046001601 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 365046001602 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 365046001603 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 365046001604 substrate binding site [chemical binding]; other site 365046001605 ATP binding site [chemical binding]; other site 365046001606 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 365046001607 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 365046001608 dimerization interface [polypeptide binding]; other site 365046001609 ligand binding site [chemical binding]; other site 365046001610 NADP binding site [chemical binding]; other site 365046001611 catalytic site [active] 365046001612 Creatinine amidohydrolase; Region: Creatininase; pfam02633 365046001613 FOG: CBS domain [General function prediction only]; Region: COG0517 365046001614 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 365046001615 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 365046001616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 365046001617 FeS/SAM binding site; other site 365046001618 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 365046001619 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 365046001620 catalytic residues [active] 365046001621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046001622 dimer interface [polypeptide binding]; other site 365046001623 phosphorylation site [posttranslational modification] 365046001624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046001625 ATP binding site [chemical binding]; other site 365046001626 Mg2+ binding site [ion binding]; other site 365046001627 G-X-G motif; other site 365046001628 Response regulator receiver domain; Region: Response_reg; pfam00072 365046001629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046001630 active site 365046001631 phosphorylation site [posttranslational modification] 365046001632 intermolecular recognition site; other site 365046001633 dimerization interface [polypeptide binding]; other site 365046001634 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 365046001635 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046001636 catalytic core [active] 365046001637 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046001638 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 365046001639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 365046001640 substrate binding pocket [chemical binding]; other site 365046001641 membrane-bound complex binding site; other site 365046001642 hinge residues; other site 365046001643 hypothetical protein; Provisional; Region: PRK06110 365046001644 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 365046001645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046001646 catalytic residue [active] 365046001647 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 365046001648 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 365046001649 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 365046001650 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 365046001651 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 365046001652 putative C-terminal domain interface [polypeptide binding]; other site 365046001653 putative GSH binding site (G-site) [chemical binding]; other site 365046001654 putative dimer interface [polypeptide binding]; other site 365046001655 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 365046001656 putative N-terminal domain interface [polypeptide binding]; other site 365046001657 putative dimer interface [polypeptide binding]; other site 365046001658 putative substrate binding pocket (H-site) [chemical binding]; other site 365046001659 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 365046001660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046001661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046001662 homodimer interface [polypeptide binding]; other site 365046001663 catalytic residue [active] 365046001664 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 365046001665 EamA-like transporter family; Region: EamA; pfam00892 365046001666 EamA-like transporter family; Region: EamA; pfam00892 365046001667 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 365046001668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046001669 DNA-binding site [nucleotide binding]; DNA binding site 365046001670 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 365046001671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046001672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046001673 homodimer interface [polypeptide binding]; other site 365046001674 catalytic residue [active] 365046001675 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 365046001676 PLD-like domain; Region: PLDc_2; pfam13091 365046001677 putative active site [active] 365046001678 catalytic site [active] 365046001679 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 365046001680 PLD-like domain; Region: PLDc_2; pfam13091 365046001681 putative active site [active] 365046001682 catalytic site [active] 365046001683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046001684 ABC transporter ATPase component; Reviewed; Region: PRK11147 365046001685 Walker A/P-loop; other site 365046001686 ATP binding site [chemical binding]; other site 365046001687 Q-loop/lid; other site 365046001688 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 365046001689 ABC transporter signature motif; other site 365046001690 Walker B; other site 365046001691 ABC transporter; Region: ABC_tran_2; pfam12848 365046001692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 365046001693 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 365046001694 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046001695 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 365046001696 acyl-activating enzyme (AAE) consensus motif; other site 365046001697 putative AMP binding site [chemical binding]; other site 365046001698 putative active site [active] 365046001699 putative CoA binding site [chemical binding]; other site 365046001700 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046001701 PGAP1-like protein; Region: PGAP1; pfam07819 365046001702 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046001703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046001704 DNA binding residues [nucleotide binding] 365046001705 dimerization interface [polypeptide binding]; other site 365046001706 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 365046001707 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 365046001708 ligand binding site [chemical binding]; other site 365046001709 flexible hinge region; other site 365046001710 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 365046001711 putative switch regulator; other site 365046001712 non-specific DNA interactions [nucleotide binding]; other site 365046001713 DNA binding site [nucleotide binding] 365046001714 sequence specific DNA binding site [nucleotide binding]; other site 365046001715 putative cAMP binding site [chemical binding]; other site 365046001716 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 365046001717 cyclase homology domain; Region: CHD; cd07302 365046001718 nucleotidyl binding site; other site 365046001719 metal binding site [ion binding]; metal-binding site 365046001720 dimer interface [polypeptide binding]; other site 365046001721 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 365046001722 cofactor binding site; other site 365046001723 metal binding site [ion binding]; metal-binding site 365046001724 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 365046001725 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 365046001726 dimer interface [polypeptide binding]; other site 365046001727 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 365046001728 active site 365046001729 Fe binding site [ion binding]; other site 365046001730 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 365046001731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046001732 putative DNA binding site [nucleotide binding]; other site 365046001733 putative Zn2+ binding site [ion binding]; other site 365046001734 AsnC family; Region: AsnC_trans_reg; pfam01037 365046001735 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 365046001736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046001737 Coenzyme A binding pocket [chemical binding]; other site 365046001738 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 365046001739 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 365046001740 Transporter associated domain; Region: CorC_HlyC; smart01091 365046001741 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 365046001742 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 365046001743 putative active site [active] 365046001744 catalytic triad [active] 365046001745 putative dimer interface [polypeptide binding]; other site 365046001746 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 365046001747 dimer interface [polypeptide binding]; other site 365046001748 motif 1; other site 365046001749 active site 365046001750 motif 2; other site 365046001751 motif 3; other site 365046001752 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 365046001753 DALR anticodon binding domain; Region: DALR_1; pfam05746 365046001754 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 365046001755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046001756 active site 365046001757 motif I; other site 365046001758 motif II; other site 365046001759 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 365046001760 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 365046001761 putative acyl-acceptor binding pocket; other site 365046001762 Protein of unknown function DUF45; Region: DUF45; pfam01863 365046001763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046001764 dimerization interface [polypeptide binding]; other site 365046001765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046001766 PAS fold; Region: PAS_3; pfam08447 365046001767 putative active site [active] 365046001768 heme pocket [chemical binding]; other site 365046001769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046001770 dimer interface [polypeptide binding]; other site 365046001771 phosphorylation site [posttranslational modification] 365046001772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046001773 ATP binding site [chemical binding]; other site 365046001774 Mg2+ binding site [ion binding]; other site 365046001775 G-X-G motif; other site 365046001776 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 365046001777 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 365046001778 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 365046001779 DNA binding residues [nucleotide binding] 365046001780 putative dimer interface [polypeptide binding]; other site 365046001781 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046001782 CoenzymeA binding site [chemical binding]; other site 365046001783 subunit interaction site [polypeptide binding]; other site 365046001784 PHB binding site; other site 365046001785 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 365046001786 isovaleryl-CoA dehydrogenase; Region: PLN02519 365046001787 substrate binding site [chemical binding]; other site 365046001788 FAD binding site [chemical binding]; other site 365046001789 catalytic base [active] 365046001790 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 365046001791 active site clefts [active] 365046001792 zinc binding site [ion binding]; other site 365046001793 dimer interface [polypeptide binding]; other site 365046001794 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 365046001795 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 365046001796 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 365046001797 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 365046001798 dimer interface [polypeptide binding]; other site 365046001799 active site 365046001800 C factor cell-cell signaling protein; Provisional; Region: PRK09009 365046001801 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 365046001802 NADP binding site [chemical binding]; other site 365046001803 homodimer interface [polypeptide binding]; other site 365046001804 active site 365046001805 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 365046001806 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 365046001807 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 365046001808 putative active site [active] 365046001809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046001810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046001811 active site 365046001812 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 365046001813 TrkA-N domain; Region: TrkA_N; pfam02254 365046001814 TrkA-C domain; Region: TrkA_C; pfam02080 365046001815 TrkA-N domain; Region: TrkA_N; pfam02254 365046001816 TrkA-C domain; Region: TrkA_C; pfam02080 365046001817 Cation transport protein; Region: TrkH; cl17365 365046001818 hypothetical protein; Provisional; Region: PRK01842 365046001819 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 365046001820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046001821 active site 365046001822 motif I; other site 365046001823 motif II; other site 365046001824 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 365046001825 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 365046001826 oligomer interface [polypeptide binding]; other site 365046001827 active site residues [active] 365046001828 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 365046001829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046001830 dimer interface [polypeptide binding]; other site 365046001831 phosphorylation site [posttranslational modification] 365046001832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046001833 ATP binding site [chemical binding]; other site 365046001834 Mg2+ binding site [ion binding]; other site 365046001835 G-X-G motif; other site 365046001836 Response regulator receiver domain; Region: Response_reg; pfam00072 365046001837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046001838 active site 365046001839 phosphorylation site [posttranslational modification] 365046001840 intermolecular recognition site; other site 365046001841 dimerization interface [polypeptide binding]; other site 365046001842 Restriction endonuclease; Region: Mrr_cat; pfam04471 365046001843 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 365046001844 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 365046001845 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 365046001846 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 365046001847 nucleotide sensor; other site 365046001848 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 365046001849 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046001850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046001851 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 365046001852 tartrate dehydrogenase; Region: TTC; TIGR02089 365046001853 transcriptional activator TtdR; Provisional; Region: PRK09801 365046001854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046001855 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 365046001856 putative effector binding pocket; other site 365046001857 putative dimerization interface [polypeptide binding]; other site 365046001858 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 365046001859 active site 365046001860 pseudouridine synthase; Region: TIGR00093 365046001861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046001862 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 365046001863 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 365046001864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046001865 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 365046001866 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046001867 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 365046001868 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 365046001869 NAD(P) binding site [chemical binding]; other site 365046001870 enoyl-CoA hydratase; Provisional; Region: PRK06127 365046001871 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046001872 substrate binding site [chemical binding]; other site 365046001873 oxyanion hole (OAH) forming residues; other site 365046001874 trimer interface [polypeptide binding]; other site 365046001875 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046001876 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046001877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046001878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046001879 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 365046001880 putative dimerization interface [polypeptide binding]; other site 365046001881 Predicted acetyltransferase [General function prediction only]; Region: COG2388 365046001882 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046001883 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046001884 von Willebrand factor type A domain; Region: VWA_2; pfam13519 365046001885 metal ion-dependent adhesion site (MIDAS); other site 365046001886 Uncharacterized conserved protein [Function unknown]; Region: COG0397 365046001887 hypothetical protein; Validated; Region: PRK00029 365046001888 glutamate dehydrogenase; Provisional; Region: PRK09414 365046001889 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 365046001890 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 365046001891 NAD(P) binding site [chemical binding]; other site 365046001892 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 365046001893 Uncharacterized conserved protein [Function unknown]; Region: COG2128 365046001894 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 365046001895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 365046001896 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 365046001897 DNA binding residues [nucleotide binding] 365046001898 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 365046001899 Ligand Binding Site [chemical binding]; other site 365046001900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 365046001901 Ligand Binding Site [chemical binding]; other site 365046001902 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 365046001903 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 365046001904 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 365046001905 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 365046001906 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 365046001907 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 365046001908 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 365046001909 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 365046001910 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 365046001911 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 365046001912 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 365046001913 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 365046001914 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 365046001915 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 365046001916 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 365046001917 putative active site [active] 365046001918 metal binding site [ion binding]; metal-binding site 365046001919 Probable beta-xylosidase; Provisional; Region: PLN03080 365046001920 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 365046001921 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 365046001922 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 365046001923 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 365046001924 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 365046001925 D-pathway; other site 365046001926 Low-spin heme binding site [chemical binding]; other site 365046001927 Putative water exit pathway; other site 365046001928 Binuclear center (active site) [active] 365046001929 K-pathway; other site 365046001930 Putative proton exit pathway; other site 365046001931 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 365046001932 Subunit I/III interface [polypeptide binding]; other site 365046001933 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 365046001934 Cytochrome c; Region: Cytochrom_C; pfam00034 365046001935 Cytochrome c553 [Energy production and conversion]; Region: COG2863 365046001936 Cytochrome c; Region: Cytochrom_C; cl11414 365046001937 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 365046001938 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 365046001939 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 365046001940 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 365046001941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046001942 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 365046001943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046001944 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 365046001945 Ligand Binding Site [chemical binding]; other site 365046001946 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 365046001947 Ligand Binding Site [chemical binding]; other site 365046001948 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 365046001949 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 365046001950 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 365046001951 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 365046001952 catalytic residues [active] 365046001953 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 365046001954 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 365046001955 putative heme binding pocket [chemical binding]; other site 365046001956 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 365046001957 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 365046001958 putative active site pocket [active] 365046001959 metal binding site [ion binding]; metal-binding site 365046001960 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 365046001961 glutaminase; Provisional; Region: PRK00971 365046001962 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 365046001963 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 365046001964 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 365046001965 dimerization interface [polypeptide binding]; other site 365046001966 GXWXG protein; Region: GXWXG; pfam14231 365046001967 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 365046001968 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 365046001969 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 365046001970 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 365046001971 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046001972 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 365046001973 recombination associated protein; Reviewed; Region: rdgC; PRK00321 365046001974 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 365046001975 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 365046001976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046001977 putative substrate translocation pore; other site 365046001978 TraX protein; Region: TraX; cl05434 365046001979 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 365046001980 Uncharacterized conserved protein [Function unknown]; Region: COG1262 365046001981 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 365046001982 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 365046001983 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 365046001984 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 365046001985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 365046001986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046001987 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 365046001988 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 365046001989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046001990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046001991 active site 365046001992 enoyl-CoA hydratase; Provisional; Region: PRK05995 365046001993 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046001994 substrate binding site [chemical binding]; other site 365046001995 oxyanion hole (OAH) forming residues; other site 365046001996 trimer interface [polypeptide binding]; other site 365046001997 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 365046001998 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 365046001999 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 365046002000 ATP-grasp domain; Region: ATP-grasp_4; cl17255 365046002001 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 365046002002 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 365046002003 carboxyltransferase (CT) interaction site; other site 365046002004 biotinylation site [posttranslational modification]; other site 365046002005 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 365046002006 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 365046002007 putative ligand binding site [chemical binding]; other site 365046002008 NAD binding site [chemical binding]; other site 365046002009 dimerization interface [polypeptide binding]; other site 365046002010 catalytic site [active] 365046002011 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 365046002012 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 365046002013 active site 365046002014 catalytic residues [active] 365046002015 metal binding site [ion binding]; metal-binding site 365046002016 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 365046002017 putative deacylase active site [active] 365046002018 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 365046002019 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 365046002020 putative catalytic residue [active] 365046002021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046002022 putative substrate translocation pore; other site 365046002023 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 365046002024 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 365046002025 putative ligand binding site [chemical binding]; other site 365046002026 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 365046002027 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 365046002028 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 365046002029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046002030 Walker A/P-loop; other site 365046002031 ATP binding site [chemical binding]; other site 365046002032 Q-loop/lid; other site 365046002033 ABC transporter signature motif; other site 365046002034 Walker B; other site 365046002035 D-loop; other site 365046002036 H-loop/switch region; other site 365046002037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046002038 Walker A/P-loop; other site 365046002039 ATP binding site [chemical binding]; other site 365046002040 Q-loop/lid; other site 365046002041 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 365046002042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046002043 Walker A/P-loop; other site 365046002044 ATP binding site [chemical binding]; other site 365046002045 Q-loop/lid; other site 365046002046 ABC transporter signature motif; other site 365046002047 Walker B; other site 365046002048 D-loop; other site 365046002049 H-loop/switch region; other site 365046002050 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 365046002051 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 365046002052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046002053 putative substrate translocation pore; other site 365046002054 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046002055 Peptidase C26; Region: Peptidase_C26; pfam07722 365046002056 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 365046002057 catalytic triad [active] 365046002058 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 365046002059 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 365046002060 catalytic triad [active] 365046002061 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 365046002062 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 365046002063 Catalytic dyad [active] 365046002064 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 365046002065 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 365046002066 G1 box; other site 365046002067 putative GEF interaction site [polypeptide binding]; other site 365046002068 GTP/Mg2+ binding site [chemical binding]; other site 365046002069 Switch I region; other site 365046002070 G2 box; other site 365046002071 G3 box; other site 365046002072 Switch II region; other site 365046002073 G4 box; other site 365046002074 G5 box; other site 365046002075 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 365046002076 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 365046002077 nucleotide binding site [chemical binding]; other site 365046002078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 365046002079 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 365046002080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 365046002081 active site 365046002082 Methyltransferase domain; Region: Methyltransf_31; pfam13847 365046002083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046002084 S-adenosylmethionine binding site [chemical binding]; other site 365046002085 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 365046002086 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 365046002087 active site 365046002088 substrate binding site [chemical binding]; other site 365046002089 metal binding site [ion binding]; metal-binding site 365046002090 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 365046002091 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 365046002092 active site 365046002093 DNA binding site [nucleotide binding] 365046002094 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 365046002095 DNA binding site [nucleotide binding] 365046002096 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 365046002097 active site 365046002098 NTP binding site [chemical binding]; other site 365046002099 metal binding triad [ion binding]; metal-binding site 365046002100 antibiotic binding site [chemical binding]; other site 365046002101 Uncharacterized conserved protein [Function unknown]; Region: COG2361 365046002102 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 365046002103 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 365046002104 homotetramer interface [polypeptide binding]; other site 365046002105 ligand binding site [chemical binding]; other site 365046002106 catalytic site [active] 365046002107 NAD binding site [chemical binding]; other site 365046002108 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 365046002109 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 365046002110 RNA binding surface [nucleotide binding]; other site 365046002111 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 365046002112 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 365046002113 FAD binding site [chemical binding]; other site 365046002114 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 365046002115 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 365046002116 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 365046002117 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 365046002118 FAD binding pocket [chemical binding]; other site 365046002119 FAD binding motif [chemical binding]; other site 365046002120 phosphate binding motif [ion binding]; other site 365046002121 beta-alpha-beta structure motif; other site 365046002122 NAD(p) ribose binding residues [chemical binding]; other site 365046002123 NAD binding pocket [chemical binding]; other site 365046002124 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 365046002125 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046002126 catalytic loop [active] 365046002127 iron binding site [ion binding]; other site 365046002128 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 365046002129 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 365046002130 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 365046002131 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 365046002132 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 365046002133 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 365046002134 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 365046002135 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 365046002136 23S rRNA interface [nucleotide binding]; other site 365046002137 L3 interface [polypeptide binding]; other site 365046002138 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 365046002139 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 365046002140 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 365046002141 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 365046002142 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 365046002143 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 365046002144 Peptidase family M23; Region: Peptidase_M23; pfam01551 365046002145 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 365046002146 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 365046002147 active site 365046002148 HIGH motif; other site 365046002149 dimer interface [polypeptide binding]; other site 365046002150 KMSKS motif; other site 365046002151 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 365046002152 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 365046002153 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 365046002154 putative active site [active] 365046002155 dimerization interface [polypeptide binding]; other site 365046002156 putative tRNAtyr binding site [nucleotide binding]; other site 365046002157 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 365046002158 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 365046002159 PhoH-like protein; Region: PhoH; pfam02562 365046002160 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 365046002161 RuvA N terminal domain; Region: RuvA_N; pfam01330 365046002162 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 365046002163 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 365046002164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046002165 Walker A motif; other site 365046002166 ATP binding site [chemical binding]; other site 365046002167 Walker B motif; other site 365046002168 arginine finger; other site 365046002169 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 365046002170 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 365046002171 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 365046002172 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 365046002173 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 365046002174 active site 365046002175 metal binding site [ion binding]; metal-binding site 365046002176 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 365046002177 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 365046002178 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 365046002179 dimer interface [polypeptide binding]; other site 365046002180 active site 365046002181 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 365046002182 substrate binding site [chemical binding]; other site 365046002183 catalytic residue [active] 365046002184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046002185 catalytic core [active] 365046002186 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 365046002187 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 365046002188 Ligand Binding Site [chemical binding]; other site 365046002189 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046002190 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 365046002191 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 365046002192 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 365046002193 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046002194 Dihydroneopterin aldolase; Region: FolB; smart00905 365046002195 active site 365046002196 short chain dehydrogenase; Provisional; Region: PRK09134 365046002197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046002198 NAD(P) binding site [chemical binding]; other site 365046002199 active site 365046002200 Uncharacterized conserved protein [Function unknown]; Region: COG1565 365046002201 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 365046002202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 365046002203 nucleotide binding site [chemical binding]; other site 365046002204 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 365046002205 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 365046002206 Walker A/P-loop; other site 365046002207 ATP binding site [chemical binding]; other site 365046002208 Q-loop/lid; other site 365046002209 ABC transporter signature motif; other site 365046002210 Walker B; other site 365046002211 D-loop; other site 365046002212 H-loop/switch region; other site 365046002213 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 365046002214 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046002215 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 365046002216 TM-ABC transporter signature motif; other site 365046002217 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 365046002218 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 365046002219 putative ligand binding site [chemical binding]; other site 365046002220 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 365046002221 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 365046002222 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 365046002223 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 365046002224 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 365046002225 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 365046002226 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 365046002227 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 365046002228 nucleotide binding site [chemical binding]; other site 365046002229 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 365046002230 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 365046002231 active site 365046002232 NTP binding site [chemical binding]; other site 365046002233 metal binding triad [ion binding]; metal-binding site 365046002234 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 365046002235 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 365046002236 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 365046002237 dihydrodipicolinate synthase; Region: dapA; TIGR00674 365046002238 dimer interface [polypeptide binding]; other site 365046002239 active site 365046002240 catalytic residue [active] 365046002241 glutathione S-transferase; Provisional; Region: PRK15113 365046002242 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 365046002243 putative C-terminal domain interface [polypeptide binding]; other site 365046002244 putative GSH binding site (G-site) [chemical binding]; other site 365046002245 putative dimer interface [polypeptide binding]; other site 365046002246 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 365046002247 putative N-terminal domain interface [polypeptide binding]; other site 365046002248 putative dimer interface [polypeptide binding]; other site 365046002249 putative substrate binding pocket (H-site) [chemical binding]; other site 365046002250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046002251 putative DNA binding site [nucleotide binding]; other site 365046002252 putative Zn2+ binding site [ion binding]; other site 365046002253 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 365046002254 putative hydrophobic ligand binding site [chemical binding]; other site 365046002255 Uncharacterized conserved protein [Function unknown]; Region: COG3791 365046002256 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 365046002257 MgtC family; Region: MgtC; pfam02308 365046002258 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 365046002259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 365046002260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 365046002261 catalytic residue [active] 365046002262 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 365046002263 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 365046002264 Beta-lactamase; Region: Beta-lactamase; pfam00144 365046002265 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 365046002266 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 365046002267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046002268 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 365046002269 dimerization interface [polypeptide binding]; other site 365046002270 substrate binding pocket [chemical binding]; other site 365046002271 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 365046002272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 365046002273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046002274 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 365046002275 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 365046002276 ATP-binding site [chemical binding]; other site 365046002277 Gluconate-6-phosphate binding site [chemical binding]; other site 365046002278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 365046002279 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 365046002280 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 365046002281 Substrate binding site; other site 365046002282 Mg++ binding site; other site 365046002283 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 365046002284 active site 365046002285 substrate binding site [chemical binding]; other site 365046002286 CoA binding site [chemical binding]; other site 365046002287 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 365046002288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 365046002289 active site 365046002290 catalytic tetrad [active] 365046002291 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 365046002292 homotrimer interaction site [polypeptide binding]; other site 365046002293 putative active site [active] 365046002294 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 365046002295 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 365046002296 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 365046002297 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 365046002298 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 365046002299 active site 365046002300 catalytic tetrad [active] 365046002301 TIGR04076 family protein; Region: TIGR04076 365046002302 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046002303 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046002304 Walker A/P-loop; other site 365046002305 ATP binding site [chemical binding]; other site 365046002306 Q-loop/lid; other site 365046002307 ABC transporter signature motif; other site 365046002308 Walker B; other site 365046002309 D-loop; other site 365046002310 H-loop/switch region; other site 365046002311 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046002312 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046002313 Walker A/P-loop; other site 365046002314 ATP binding site [chemical binding]; other site 365046002315 Q-loop/lid; other site 365046002316 ABC transporter signature motif; other site 365046002317 Walker B; other site 365046002318 D-loop; other site 365046002319 H-loop/switch region; other site 365046002320 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046002321 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046002322 TM-ABC transporter signature motif; other site 365046002323 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046002324 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046002325 TM-ABC transporter signature motif; other site 365046002326 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 365046002327 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 365046002328 AsnC family; Region: AsnC_trans_reg; pfam01037 365046002329 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 365046002330 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 365046002331 glutaminase active site [active] 365046002332 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 365046002333 dimer interface [polypeptide binding]; other site 365046002334 active site 365046002335 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 365046002336 dimer interface [polypeptide binding]; other site 365046002337 active site 365046002338 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 365046002339 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 365046002340 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 365046002341 AMIN domain; Region: AMIN; pfam11741 365046002342 beta-carotene hydroxylase; Region: PLN02601 365046002343 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 365046002344 putative di-iron ligands [ion binding]; other site 365046002345 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 365046002346 active site lid residues [active] 365046002347 substrate binding pocket [chemical binding]; other site 365046002348 catalytic residues [active] 365046002349 substrate-Mg2+ binding site; other site 365046002350 aspartate-rich region 1; other site 365046002351 aspartate-rich region 2; other site 365046002352 phytoene desaturase; Region: crtI_fam; TIGR02734 365046002353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 365046002354 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 365046002355 lycopene cyclase; Region: lycopene_cycl; TIGR01789 365046002356 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 365046002357 glycosyltransferase, MGT family; Region: MGT; TIGR01426 365046002358 active site 365046002359 TDP-binding site; other site 365046002360 acceptor substrate-binding pocket; other site 365046002361 homodimer interface [polypeptide binding]; other site 365046002362 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 365046002363 substrate binding pocket [chemical binding]; other site 365046002364 substrate-Mg2+ binding site; other site 365046002365 aspartate-rich region 1; other site 365046002366 aspartate-rich region 2; other site 365046002367 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 365046002368 putative substrate binding site [chemical binding]; other site 365046002369 putative ATP binding site [chemical binding]; other site 365046002370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046002371 catalytic core [active] 365046002372 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 365046002373 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 365046002374 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 365046002375 active site 365046002376 DNA binding site [nucleotide binding] 365046002377 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 365046002378 DNA binding site [nucleotide binding] 365046002379 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 365046002380 nucleotide binding site [chemical binding]; other site 365046002381 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 365046002382 Amino acid permease; Region: AA_permease_2; pfam13520 365046002383 Spore germination protein; Region: Spore_permease; cl17796 365046002384 Methyltransferase domain; Region: Methyltransf_31; pfam13847 365046002385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046002386 S-adenosylmethionine binding site [chemical binding]; other site 365046002387 S-adenosylmethionine synthetase; Validated; Region: PRK05250 365046002388 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 365046002389 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 365046002390 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 365046002391 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 365046002392 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 365046002393 putative acyl-acceptor binding pocket; other site 365046002394 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 365046002395 putative acyl-acceptor binding pocket; other site 365046002396 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 365046002397 G1 box; other site 365046002398 GTP/Mg2+ binding site [chemical binding]; other site 365046002399 Switch I region; other site 365046002400 G2 box; other site 365046002401 G3 box; other site 365046002402 Switch II region; other site 365046002403 G4 box; other site 365046002404 G5 box; other site 365046002405 Cytochrome c553 [Energy production and conversion]; Region: COG2863 365046002406 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 365046002407 Cytochrome c; Region: Cytochrom_C; cl11414 365046002408 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 365046002409 ResB-like family; Region: ResB; pfam05140 365046002410 ResB-like family; Region: ResB; pfam05140 365046002411 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 365046002412 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 365046002413 TMAO/DMSO reductase; Reviewed; Region: PRK05363 365046002414 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 365046002415 Moco binding site; other site 365046002416 metal coordination site [ion binding]; other site 365046002417 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 365046002418 diaminopimelate decarboxylase; Region: lysA; TIGR01048 365046002419 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 365046002420 active site 365046002421 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 365046002422 substrate binding site [chemical binding]; other site 365046002423 catalytic residues [active] 365046002424 dimer interface [polypeptide binding]; other site 365046002425 Frataxin-like domain; Region: Frataxin_Cyay; pfam01491 365046002426 putative iron binding site [ion binding]; other site 365046002427 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 365046002428 Transglycosylase; Region: Transgly; pfam00912 365046002429 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 365046002430 Competence protein A; Region: Competence_A; pfam11104 365046002431 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 365046002432 nucleotide binding site [chemical binding]; other site 365046002433 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 365046002434 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 365046002435 Pilus assembly protein, PilO; Region: PilO; pfam04350 365046002436 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 365046002437 Pilus assembly protein, PilP; Region: PilP; pfam04351 365046002438 AMIN domain; Region: AMIN; pfam11741 365046002439 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 365046002440 Secretin and TonB N terminus short domain; Region: STN; pfam07660 365046002441 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 365046002442 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 365046002443 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 365046002444 Shikimate kinase; Region: SKI; pfam01202 365046002445 ADP binding site [chemical binding]; other site 365046002446 magnesium binding site [ion binding]; other site 365046002447 putative shikimate binding site; other site 365046002448 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 365046002449 active site 365046002450 dimer interface [polypeptide binding]; other site 365046002451 metal binding site [ion binding]; metal-binding site 365046002452 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 365046002453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 365046002454 Zn2+ binding site [ion binding]; other site 365046002455 Mg2+ binding site [ion binding]; other site 365046002456 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 365046002457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046002458 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 365046002459 Methyltransferase domain; Region: Methyltransf_32; pfam13679 365046002460 Methyltransferase domain; Region: Methyltransf_31; pfam13847 365046002461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 365046002462 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 365046002463 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 365046002464 active site 365046002465 dimer interface [polypeptide binding]; other site 365046002466 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 365046002467 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 365046002468 active site 365046002469 FMN binding site [chemical binding]; other site 365046002470 substrate binding site [chemical binding]; other site 365046002471 3Fe-4S cluster binding site [ion binding]; other site 365046002472 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 365046002473 domain interface; other site 365046002474 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 365046002475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046002476 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 365046002477 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 365046002478 Walker A/P-loop; other site 365046002479 ATP binding site [chemical binding]; other site 365046002480 Q-loop/lid; other site 365046002481 ABC transporter signature motif; other site 365046002482 Walker B; other site 365046002483 D-loop; other site 365046002484 H-loop/switch region; other site 365046002485 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 365046002486 Permease; Region: Permease; pfam02405 365046002487 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 365046002488 mce related protein; Region: MCE; pfam02470 365046002489 VacJ like lipoprotein; Region: VacJ; cl01073 365046002490 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 365046002491 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 365046002492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 365046002493 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 365046002494 Walker A/P-loop; other site 365046002495 ATP binding site [chemical binding]; other site 365046002496 Q-loop/lid; other site 365046002497 ABC transporter signature motif; other site 365046002498 Walker B; other site 365046002499 D-loop; other site 365046002500 H-loop/switch region; other site 365046002501 ABC-2 type transporter; Region: ABC2_membrane; cl17235 365046002502 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 365046002503 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 365046002504 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 365046002505 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 365046002506 hinge; other site 365046002507 active site 365046002508 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 365046002509 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 365046002510 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 365046002511 histidinol dehydrogenase; Region: hisD; TIGR00069 365046002512 NAD binding site [chemical binding]; other site 365046002513 dimerization interface [polypeptide binding]; other site 365046002514 product binding site; other site 365046002515 substrate binding site [chemical binding]; other site 365046002516 zinc binding site [ion binding]; other site 365046002517 catalytic residues [active] 365046002518 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 365046002519 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046002520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046002521 homodimer interface [polypeptide binding]; other site 365046002522 catalytic residue [active] 365046002523 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 365046002524 putative active site pocket [active] 365046002525 4-fold oligomerization interface [polypeptide binding]; other site 365046002526 metal binding residues [ion binding]; metal-binding site 365046002527 3-fold/trimer interface [polypeptide binding]; other site 365046002528 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 365046002529 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 365046002530 putative active site [active] 365046002531 oxyanion strand; other site 365046002532 catalytic triad [active] 365046002533 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 365046002534 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 365046002535 catalytic residues [active] 365046002536 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 365046002537 active site 365046002538 phosphate binding residues; other site 365046002539 catalytic residues [active] 365046002540 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 365046002541 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 365046002542 substrate binding site [chemical binding]; other site 365046002543 glutamase interaction surface [polypeptide binding]; other site 365046002544 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 365046002545 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 365046002546 metal binding site [ion binding]; metal-binding site 365046002547 Predicted membrane protein [Function unknown]; Region: COG3671 365046002548 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 365046002549 nucleotide binding site/active site [active] 365046002550 HIT family signature motif; other site 365046002551 catalytic residue [active] 365046002552 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 365046002553 sec-independent translocase; Provisional; Region: tatB; PRK01919 365046002554 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 365046002555 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 365046002556 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 365046002557 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 365046002558 TrkA-N domain; Region: TrkA_N; pfam02254 365046002559 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 365046002560 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 365046002561 protein binding site [polypeptide binding]; other site 365046002562 Uncharacterized conserved protein [Function unknown]; Region: COG0327 365046002563 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 365046002564 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 365046002565 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 365046002566 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 365046002567 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 365046002568 [2Fe-2S] cluster binding site [ion binding]; other site 365046002569 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 365046002570 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 365046002571 Qi binding site; other site 365046002572 intrachain domain interface; other site 365046002573 interchain domain interface [polypeptide binding]; other site 365046002574 heme bH binding site [chemical binding]; other site 365046002575 heme bL binding site [chemical binding]; other site 365046002576 Qo binding site; other site 365046002577 interchain domain interface [polypeptide binding]; other site 365046002578 intrachain domain interface; other site 365046002579 Qi binding site; other site 365046002580 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 365046002581 Qo binding site; other site 365046002582 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 365046002583 stringent starvation protein A; Provisional; Region: sspA; PRK09481 365046002584 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 365046002585 C-terminal domain interface [polypeptide binding]; other site 365046002586 putative GSH binding site (G-site) [chemical binding]; other site 365046002587 dimer interface [polypeptide binding]; other site 365046002588 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 365046002589 dimer interface [polypeptide binding]; other site 365046002590 N-terminal domain interface [polypeptide binding]; other site 365046002591 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 365046002592 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 365046002593 Peptidase family M23; Region: Peptidase_M23; pfam01551 365046002594 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 365046002595 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 365046002596 SEC-C motif; Region: SEC-C; pfam02810 365046002597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046002598 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 365046002599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046002600 catalytic residue [active] 365046002601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046002602 active site 365046002603 phosphorylation site [posttranslational modification] 365046002604 intermolecular recognition site; other site 365046002605 dimerization interface [polypeptide binding]; other site 365046002606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046002607 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 365046002608 dimer interface [polypeptide binding]; other site 365046002609 phosphorylation site [posttranslational modification] 365046002610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046002611 ATP binding site [chemical binding]; other site 365046002612 Mg2+ binding site [ion binding]; other site 365046002613 G-X-G motif; other site 365046002614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046002615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046002616 DNA binding residues [nucleotide binding] 365046002617 dimerization interface [polypeptide binding]; other site 365046002618 pantothenate kinase; Reviewed; Region: PRK13329 365046002619 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 365046002620 putative active site [active] 365046002621 Zn binding site [ion binding]; other site 365046002622 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 365046002623 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 365046002624 metal binding site [ion binding]; metal-binding site 365046002625 putative dimer interface [polypeptide binding]; other site 365046002626 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 365046002627 acetylornithine deacetylase; Provisional; Region: PRK07522 365046002628 metal binding site [ion binding]; metal-binding site 365046002629 putative dimer interface [polypeptide binding]; other site 365046002630 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 365046002631 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 365046002632 putative ligand binding site [chemical binding]; other site 365046002633 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 365046002634 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 365046002635 putative [4Fe-4S] binding site [ion binding]; other site 365046002636 putative molybdopterin cofactor binding site [chemical binding]; other site 365046002637 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 365046002638 putative molybdopterin cofactor binding site; other site 365046002639 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 365046002640 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 365046002641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046002642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046002643 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 365046002644 putative dimerization interface [polypeptide binding]; other site 365046002645 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046002646 Acyl CoA binding protein; Region: ACBP; pfam00887 365046002647 acyl-CoA binding pocket [chemical binding]; other site 365046002648 CoA binding site [chemical binding]; other site 365046002649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 365046002650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046002651 Bacterial transcriptional repressor; Region: TetR; pfam13972 365046002652 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 365046002653 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 365046002654 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 365046002655 NAD binding site [chemical binding]; other site 365046002656 substrate binding site [chemical binding]; other site 365046002657 homodimer interface [polypeptide binding]; other site 365046002658 active site 365046002659 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 365046002660 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 365046002661 NADP binding site [chemical binding]; other site 365046002662 active site 365046002663 putative substrate binding site [chemical binding]; other site 365046002664 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 365046002665 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 365046002666 substrate binding site; other site 365046002667 tetramer interface; other site 365046002668 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 365046002669 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 365046002670 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 365046002671 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 365046002672 Walker A/P-loop; other site 365046002673 ATP binding site [chemical binding]; other site 365046002674 Q-loop/lid; other site 365046002675 ABC transporter signature motif; other site 365046002676 Walker B; other site 365046002677 D-loop; other site 365046002678 H-loop/switch region; other site 365046002679 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 365046002680 putative carbohydrate binding site [chemical binding]; other site 365046002681 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 365046002682 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 365046002683 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046002684 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 365046002685 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 365046002686 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 365046002687 Ligand binding site; other site 365046002688 Putative Catalytic site; other site 365046002689 DXD motif; other site 365046002690 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 365046002691 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 365046002692 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 365046002693 Probable Catalytic site; other site 365046002694 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 365046002695 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 365046002696 Probable Catalytic site; other site 365046002697 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 365046002698 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 365046002699 Probable Catalytic site; other site 365046002700 metal-binding site 365046002701 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 365046002702 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 365046002703 Mg++ binding site [ion binding]; other site 365046002704 putative catalytic motif [active] 365046002705 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 365046002706 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 365046002707 active site 365046002708 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 365046002709 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 365046002710 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 365046002711 Walker A/P-loop; other site 365046002712 ATP binding site [chemical binding]; other site 365046002713 Q-loop/lid; other site 365046002714 ABC transporter signature motif; other site 365046002715 Walker B; other site 365046002716 D-loop; other site 365046002717 H-loop/switch region; other site 365046002718 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 365046002719 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 365046002720 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 365046002721 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 365046002722 active site 365046002723 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 365046002724 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 365046002725 feedback inhibition sensing region; other site 365046002726 homohexameric interface [polypeptide binding]; other site 365046002727 nucleotide binding site [chemical binding]; other site 365046002728 N-acetyl-L-glutamate binding site [chemical binding]; other site 365046002729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 365046002730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046002731 active site 365046002732 phosphorylation site [posttranslational modification] 365046002733 intermolecular recognition site; other site 365046002734 dimerization interface [polypeptide binding]; other site 365046002735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046002736 DNA binding site [nucleotide binding] 365046002737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046002738 HAMP domain; Region: HAMP; pfam00672 365046002739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046002740 dimer interface [polypeptide binding]; other site 365046002741 phosphorylation site [posttranslational modification] 365046002742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046002743 ATP binding site [chemical binding]; other site 365046002744 Mg2+ binding site [ion binding]; other site 365046002745 G-X-G motif; other site 365046002746 division inhibitor protein; Provisional; Region: slmA; PRK09480 365046002747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046002748 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 365046002749 putative active site [active] 365046002750 putative metal binding site [ion binding]; other site 365046002751 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 365046002752 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 365046002753 putative active site [active] 365046002754 putative catalytic site [active] 365046002755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 365046002756 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 365046002757 galactarate dehydratase; Region: galactar-dH20; TIGR03248 365046002758 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 365046002759 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 365046002760 DctM-like transporters; Region: DctM; pfam06808 365046002761 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 365046002762 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 365046002763 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046002764 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046002765 Transcriptional regulators [Transcription]; Region: FadR; COG2186 365046002766 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046002767 DNA-binding site [nucleotide binding]; DNA binding site 365046002768 FCD domain; Region: FCD; pfam07729 365046002769 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 365046002770 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 365046002771 NAD binding site [chemical binding]; other site 365046002772 homotetramer interface [polypeptide binding]; other site 365046002773 homodimer interface [polypeptide binding]; other site 365046002774 active site 365046002775 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 365046002776 classical (c) SDRs; Region: SDR_c; cd05233 365046002777 NAD(P) binding site [chemical binding]; other site 365046002778 active site 365046002779 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 365046002780 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 365046002781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046002782 active site 365046002783 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046002784 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 365046002785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046002786 DNA-binding site [nucleotide binding]; DNA binding site 365046002787 UTRA domain; Region: UTRA; pfam07702 365046002788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046002789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046002790 putative substrate translocation pore; other site 365046002791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 365046002792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046002793 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 365046002794 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 365046002795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046002796 active site 365046002797 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 365046002798 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 365046002799 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046002800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046002801 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 365046002802 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 365046002803 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 365046002804 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 365046002805 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046002806 substrate binding site [chemical binding]; other site 365046002807 oxyanion hole (OAH) forming residues; other site 365046002808 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 365046002809 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 365046002810 dimer interface [polypeptide binding]; other site 365046002811 active site 365046002812 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 365046002813 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046002814 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 365046002815 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 365046002816 active site 2 [active] 365046002817 active site 1 [active] 365046002818 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 365046002819 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 365046002820 putative NAD(P) binding site [chemical binding]; other site 365046002821 active site 365046002822 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 365046002823 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 365046002824 putative catalytic residue [active] 365046002825 enoyl-CoA hydratase; Provisional; Region: PRK06688 365046002826 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046002827 substrate binding site [chemical binding]; other site 365046002828 oxyanion hole (OAH) forming residues; other site 365046002829 trimer interface [polypeptide binding]; other site 365046002830 YCII-related domain; Region: YCII; cl00999 365046002831 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 365046002832 dimer interface [polypeptide binding]; other site 365046002833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 365046002834 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046002835 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 365046002836 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 365046002837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 365046002838 Predicted acetyltransferase [General function prediction only]; Region: COG2388 365046002839 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046002840 CoenzymeA binding site [chemical binding]; other site 365046002841 subunit interaction site [polypeptide binding]; other site 365046002842 PHB binding site; other site 365046002843 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 365046002844 active site 365046002845 catalytic residue [active] 365046002846 dimer interface [polypeptide binding]; other site 365046002847 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 365046002848 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 365046002849 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 365046002850 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 365046002851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046002852 Walker A/P-loop; other site 365046002853 ATP binding site [chemical binding]; other site 365046002854 Q-loop/lid; other site 365046002855 ABC transporter signature motif; other site 365046002856 Walker B; other site 365046002857 D-loop; other site 365046002858 H-loop/switch region; other site 365046002859 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 365046002860 active site 365046002861 metal binding site [ion binding]; metal-binding site 365046002862 homotetramer interface [polypeptide binding]; other site 365046002863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046002864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 365046002865 dimerization interface [polypeptide binding]; other site 365046002866 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 365046002867 Aspartase; Region: Aspartase; cd01357 365046002868 active sites [active] 365046002869 tetramer interface [polypeptide binding]; other site 365046002870 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 365046002871 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 365046002872 substrate binding pocket [chemical binding]; other site 365046002873 membrane-bound complex binding site; other site 365046002874 hinge residues; other site 365046002875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046002876 dimer interface [polypeptide binding]; other site 365046002877 conserved gate region; other site 365046002878 putative PBP binding loops; other site 365046002879 ABC-ATPase subunit interface; other site 365046002880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046002881 dimer interface [polypeptide binding]; other site 365046002882 conserved gate region; other site 365046002883 putative PBP binding loops; other site 365046002884 ABC-ATPase subunit interface; other site 365046002885 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 365046002886 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 365046002887 Walker A/P-loop; other site 365046002888 ATP binding site [chemical binding]; other site 365046002889 Q-loop/lid; other site 365046002890 ABC transporter signature motif; other site 365046002891 Walker B; other site 365046002892 D-loop; other site 365046002893 H-loop/switch region; other site 365046002894 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 365046002895 active site 365046002896 substrate binding pocket [chemical binding]; other site 365046002897 dimer interface [polypeptide binding]; other site 365046002898 Uncharacterized conserved protein [Function unknown]; Region: COG1432 365046002899 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 365046002900 putative metal binding site [ion binding]; other site 365046002901 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 365046002902 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 365046002903 heat shock protein HtpX; Provisional; Region: PRK05457 365046002904 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 365046002905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 365046002906 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046002907 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 365046002908 Uncharacterized conserved protein [Function unknown]; Region: COG2128 365046002909 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 365046002910 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 365046002911 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 365046002912 Protein of unknown function, DUF484; Region: DUF484; cl17449 365046002913 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 365046002914 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 365046002915 active site 365046002916 DNA binding site [nucleotide binding] 365046002917 Int/Topo IB signature motif; other site 365046002918 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 365046002919 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 365046002920 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 365046002921 putative RNA binding site [nucleotide binding]; other site 365046002922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046002923 S-adenosylmethionine binding site [chemical binding]; other site 365046002924 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 365046002925 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 365046002926 P-loop, Walker A motif; other site 365046002927 Base recognition motif; other site 365046002928 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 365046002929 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 365046002930 STAS domain; Region: STAS_2; pfam13466 365046002931 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 365046002932 active site 365046002933 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 365046002934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046002935 Walker A motif; other site 365046002936 ATP binding site [chemical binding]; other site 365046002937 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 365046002938 Walker B motif; other site 365046002939 arginine finger; other site 365046002940 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 365046002941 cell division protein MraZ; Reviewed; Region: PRK00326 365046002942 MraZ protein; Region: MraZ; pfam02381 365046002943 MraZ protein; Region: MraZ; pfam02381 365046002944 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 365046002945 MraW methylase family; Region: Methyltransf_5; cl17771 365046002946 Cell division protein FtsL; Region: FtsL; pfam04999 365046002947 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 365046002948 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 365046002949 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 365046002950 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 365046002951 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 365046002952 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 365046002953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 365046002954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 365046002955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 365046002956 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 365046002957 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 365046002958 Mg++ binding site [ion binding]; other site 365046002959 putative catalytic motif [active] 365046002960 putative substrate binding site [chemical binding]; other site 365046002961 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 365046002962 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 365046002963 cell division protein FtsW; Region: ftsW; TIGR02614 365046002964 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 365046002965 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 365046002966 active site 365046002967 homodimer interface [polypeptide binding]; other site 365046002968 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 365046002969 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 365046002970 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 365046002971 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 365046002972 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 365046002973 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 365046002974 ATP-grasp domain; Region: ATP-grasp_4; cl17255 365046002975 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 365046002976 Cell division protein FtsQ; Region: FtsQ; pfam03799 365046002977 cell division protein FtsA; Region: ftsA; TIGR01174 365046002978 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 365046002979 nucleotide binding site [chemical binding]; other site 365046002980 Cell division protein FtsA; Region: FtsA; pfam14450 365046002981 cell division protein FtsZ; Validated; Region: PRK09330 365046002982 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 365046002983 nucleotide binding site [chemical binding]; other site 365046002984 SulA interaction site; other site 365046002985 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 365046002986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046002987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046002988 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 365046002989 putative effector binding pocket; other site 365046002990 putative dimerization interface [polypeptide binding]; other site 365046002991 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 365046002992 homotrimer interaction site [polypeptide binding]; other site 365046002993 putative active site [active] 365046002994 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 365046002995 active site 365046002996 putative DNA-binding cleft [nucleotide binding]; other site 365046002997 dimer interface [polypeptide binding]; other site 365046002998 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 365046002999 oligomeric interface; other site 365046003000 putative active site [active] 365046003001 homodimer interface [polypeptide binding]; other site 365046003002 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 365046003003 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 365046003004 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 365046003005 putative dimer interface [polypeptide binding]; other site 365046003006 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 365046003007 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 365046003008 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 365046003009 Transglycosylase; Region: Transgly; cl17702 365046003010 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 365046003011 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 365046003012 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 365046003013 shikimate binding site; other site 365046003014 NAD(P) binding site [chemical binding]; other site 365046003015 Gram-negative bacterial tonB protein; Region: TonB; cl10048 365046003016 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 365046003017 RNB domain; Region: RNB; pfam00773 365046003018 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 365046003019 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046003020 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 365046003021 protease TldD; Provisional; Region: tldD; PRK10735 365046003022 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 365046003023 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 365046003024 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 365046003025 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 365046003026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 365046003027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 365046003028 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 365046003029 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 365046003030 catalytic residues [active] 365046003031 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 365046003032 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 365046003033 carboxyltransferase (CT) interaction site; other site 365046003034 biotinylation site [posttranslational modification]; other site 365046003035 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 365046003036 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 365046003037 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 365046003038 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 365046003039 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 365046003040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 365046003041 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 365046003042 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 365046003043 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 365046003044 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 365046003045 substrate binding site [chemical binding]; other site 365046003046 ATP binding site [chemical binding]; other site 365046003047 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 365046003048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046003049 NAD(P) binding site [chemical binding]; other site 365046003050 active site 365046003051 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 365046003052 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046003053 TM-ABC transporter signature motif; other site 365046003054 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046003055 TM-ABC transporter signature motif; other site 365046003056 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 365046003057 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 365046003058 putative ligand binding site [chemical binding]; other site 365046003059 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046003060 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046003061 Walker A/P-loop; other site 365046003062 ATP binding site [chemical binding]; other site 365046003063 Q-loop/lid; other site 365046003064 ABC transporter signature motif; other site 365046003065 Walker B; other site 365046003066 D-loop; other site 365046003067 H-loop/switch region; other site 365046003068 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046003069 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046003070 Walker A/P-loop; other site 365046003071 ATP binding site [chemical binding]; other site 365046003072 Q-loop/lid; other site 365046003073 ABC transporter signature motif; other site 365046003074 Walker B; other site 365046003075 D-loop; other site 365046003076 H-loop/switch region; other site 365046003077 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 365046003078 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 365046003079 active site 1 [active] 365046003080 dimer interface [polypeptide binding]; other site 365046003081 hexamer interface [polypeptide binding]; other site 365046003082 active site 2 [active] 365046003083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046003084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046003085 dimerization interface [polypeptide binding]; other site 365046003086 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 365046003087 B12 binding site [chemical binding]; other site 365046003088 cobalt ligand [ion binding]; other site 365046003089 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 365046003090 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 365046003091 Walker A; other site 365046003092 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 365046003093 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 365046003094 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 365046003095 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 365046003096 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046003097 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046003098 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 365046003099 active site residue [active] 365046003100 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 365046003101 heterotetramer interface [polypeptide binding]; other site 365046003102 active site pocket [active] 365046003103 cleavage site 365046003104 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 365046003105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046003106 Walker A motif; other site 365046003107 ATP binding site [chemical binding]; other site 365046003108 Walker B motif; other site 365046003109 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 365046003110 active site 365046003111 8-oxo-dGMP binding site [chemical binding]; other site 365046003112 nudix motif; other site 365046003113 metal binding site [ion binding]; metal-binding site 365046003114 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 365046003115 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 365046003116 putative DNA binding site [nucleotide binding]; other site 365046003117 putative homodimer interface [polypeptide binding]; other site 365046003118 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 365046003119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003120 active site 365046003121 phosphorylation site [posttranslational modification] 365046003122 intermolecular recognition site; other site 365046003123 dimerization interface [polypeptide binding]; other site 365046003124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046003125 Walker A motif; other site 365046003126 ATP binding site [chemical binding]; other site 365046003127 Walker B motif; other site 365046003128 arginine finger; other site 365046003129 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 365046003130 PAS fold; Region: PAS_3; pfam08447 365046003131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046003132 putative active site [active] 365046003133 heme pocket [chemical binding]; other site 365046003134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046003135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046003136 dimer interface [polypeptide binding]; other site 365046003137 phosphorylation site [posttranslational modification] 365046003138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046003139 ATP binding site [chemical binding]; other site 365046003140 Mg2+ binding site [ion binding]; other site 365046003141 G-X-G motif; other site 365046003142 Response regulator receiver domain; Region: Response_reg; pfam00072 365046003143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003144 active site 365046003145 phosphorylation site [posttranslational modification] 365046003146 intermolecular recognition site; other site 365046003147 dimerization interface [polypeptide binding]; other site 365046003148 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 365046003149 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 365046003150 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 365046003151 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 365046003152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046003153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046003154 dimer interface [polypeptide binding]; other site 365046003155 phosphorylation site [posttranslational modification] 365046003156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046003157 ATP binding site [chemical binding]; other site 365046003158 Mg2+ binding site [ion binding]; other site 365046003159 G-X-G motif; other site 365046003160 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046003161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003162 active site 365046003163 phosphorylation site [posttranslational modification] 365046003164 intermolecular recognition site; other site 365046003165 dimerization interface [polypeptide binding]; other site 365046003166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046003167 DNA binding residues [nucleotide binding] 365046003168 dimerization interface [polypeptide binding]; other site 365046003169 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 365046003170 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 365046003171 active site 365046003172 HIGH motif; other site 365046003173 dimer interface [polypeptide binding]; other site 365046003174 KMSKS motif; other site 365046003175 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 365046003176 Peptidase family M50; Region: Peptidase_M50; pfam02163 365046003177 active site 365046003178 putative substrate binding region [chemical binding]; other site 365046003179 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 365046003180 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 365046003181 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 365046003182 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 365046003183 active site 365046003184 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 365046003185 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 365046003186 putative substrate binding pocket [chemical binding]; other site 365046003187 AC domain interface; other site 365046003188 catalytic triad [active] 365046003189 AB domain interface; other site 365046003190 interchain disulfide; other site 365046003191 Predicted metalloprotease [General function prediction only]; Region: COG2321 365046003192 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 365046003193 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 365046003194 DEAD-like helicases superfamily; Region: DEXDc; smart00487 365046003195 ATP binding site [chemical binding]; other site 365046003196 Mg++ binding site [ion binding]; other site 365046003197 motif III; other site 365046003198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046003199 nucleotide binding region [chemical binding]; other site 365046003200 ATP-binding site [chemical binding]; other site 365046003201 Domain of unknown function DUF21; Region: DUF21; pfam01595 365046003202 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 365046003203 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 365046003204 Transporter associated domain; Region: CorC_HlyC; smart01091 365046003205 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 365046003206 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 365046003207 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 365046003208 AMP binding site [chemical binding]; other site 365046003209 metal binding site [ion binding]; metal-binding site 365046003210 active site 365046003211 aminopeptidase N; Provisional; Region: pepN; PRK14015 365046003212 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 365046003213 active site 365046003214 Zn binding site [ion binding]; other site 365046003215 This domain is found in peptide chain release factors; Region: PCRF; smart00937 365046003216 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 365046003217 RF-1 domain; Region: RF-1; pfam00472 365046003218 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 365046003219 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 365046003220 Sel1-like repeats; Region: SEL1; smart00671 365046003221 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 365046003222 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 365046003223 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 365046003224 nucleophilic elbow; other site 365046003225 catalytic site [active] 365046003226 catalytic triad; other site 365046003227 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 365046003228 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 365046003229 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 365046003230 active site 365046003231 acyl-activating enzyme (AAE) consensus motif; other site 365046003232 putative CoA binding site [chemical binding]; other site 365046003233 AMP binding site [chemical binding]; other site 365046003234 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 365046003235 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 365046003236 DNA binding site [nucleotide binding] 365046003237 catalytic residue [active] 365046003238 H2TH interface [polypeptide binding]; other site 365046003239 putative catalytic residues [active] 365046003240 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 365046003241 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 365046003242 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 365046003243 active site 365046003244 catalytic tetrad [active] 365046003245 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 365046003246 putative deacylase active site [active] 365046003247 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 365046003248 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 365046003249 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 365046003250 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 365046003251 tetramer interface [polypeptide binding]; other site 365046003252 TPP-binding site [chemical binding]; other site 365046003253 heterodimer interface [polypeptide binding]; other site 365046003254 phosphorylation loop region [posttranslational modification] 365046003255 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 365046003256 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 365046003257 alpha subunit interface [polypeptide binding]; other site 365046003258 TPP binding site [chemical binding]; other site 365046003259 heterodimer interface [polypeptide binding]; other site 365046003260 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 365046003261 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 365046003262 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 365046003263 E3 interaction surface; other site 365046003264 lipoyl attachment site [posttranslational modification]; other site 365046003265 e3 binding domain; Region: E3_binding; pfam02817 365046003266 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 365046003267 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 365046003268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046003269 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 365046003270 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 365046003271 EamA-like transporter family; Region: EamA; pfam00892 365046003272 EamA-like transporter family; Region: EamA; pfam00892 365046003273 GAF domain; Region: GAF; pfam01590 365046003274 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046003275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046003276 putative active site [active] 365046003277 heme pocket [chemical binding]; other site 365046003278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046003279 dimer interface [polypeptide binding]; other site 365046003280 phosphorylation site [posttranslational modification] 365046003281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046003282 ATP binding site [chemical binding]; other site 365046003283 Mg2+ binding site [ion binding]; other site 365046003284 G-X-G motif; other site 365046003285 Response regulator receiver domain; Region: Response_reg; pfam00072 365046003286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003287 active site 365046003288 phosphorylation site [posttranslational modification] 365046003289 intermolecular recognition site; other site 365046003290 dimerization interface [polypeptide binding]; other site 365046003291 Transmembrane secretion effector; Region: MFS_3; pfam05977 365046003292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046003293 putative substrate translocation pore; other site 365046003294 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 365046003295 catalytic motif [active] 365046003296 Catalytic residue [active] 365046003297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 365046003298 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 365046003299 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 365046003300 FAD binding domain; Region: FAD_binding_4; pfam01565 365046003301 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 365046003302 argininosuccinate synthase; Validated; Region: PRK05370 365046003303 argininosuccinate synthase; Provisional; Region: PRK13820 365046003304 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 365046003305 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 365046003306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 365046003307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 365046003308 DNA binding residues [nucleotide binding] 365046003309 Anti-sigma-K factor rskA; Region: RskA; pfam10099 365046003310 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 365046003311 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 365046003312 ArsC family; Region: ArsC; pfam03960 365046003313 putative catalytic residues [active] 365046003314 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 365046003315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 365046003316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 365046003317 Sporulation related domain; Region: SPOR; pfam05036 365046003318 Colicin V production protein; Region: Colicin_V; pfam02674 365046003319 amidophosphoribosyltransferase; Provisional; Region: PRK09246 365046003320 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 365046003321 active site 365046003322 tetramer interface [polypeptide binding]; other site 365046003323 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 365046003324 active site 365046003325 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 365046003326 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 365046003327 homodimer interface [polypeptide binding]; other site 365046003328 substrate-cofactor binding pocket; other site 365046003329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046003330 catalytic residue [active] 365046003331 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 365046003332 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 365046003333 active site 365046003334 HIGH motif; other site 365046003335 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 365046003336 active site 365046003337 KMSKS motif; other site 365046003338 transcriptional regulator EpsA; Region: EpsA; TIGR03020 365046003339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046003340 DNA binding residues [nucleotide binding] 365046003341 dimerization interface [polypeptide binding]; other site 365046003342 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 365046003343 Bacterial sugar transferase; Region: Bac_transf; pfam02397 365046003344 exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014 365046003345 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 365046003346 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 365046003347 SLBB domain; Region: SLBB; pfam10531 365046003348 chain length determinant protein EpsF; Region: EpsF; TIGR03017 365046003349 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 365046003350 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 365046003351 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 365046003352 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 365046003353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046003354 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 365046003355 NAD(P) binding site [chemical binding]; other site 365046003356 active site 365046003357 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 365046003358 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 365046003359 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 365046003360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046003361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 365046003362 active site 365046003363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 365046003364 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 365046003365 active site 365046003366 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 365046003367 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 365046003368 active site 365046003369 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 365046003370 O-Antigen ligase; Region: Wzy_C; pfam04932 365046003371 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 365046003372 VanZ like family; Region: VanZ; cl01971 365046003373 EamA-like transporter family; Region: EamA; pfam00892 365046003374 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 365046003375 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 365046003376 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 365046003377 DNA binding site [nucleotide binding] 365046003378 active site 365046003379 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 365046003380 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 365046003381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046003382 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 365046003383 AlkA N-terminal domain; Region: AlkA_N; pfam06029 365046003384 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 365046003385 minor groove reading motif; other site 365046003386 helix-hairpin-helix signature motif; other site 365046003387 substrate binding pocket [chemical binding]; other site 365046003388 active site 365046003389 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 365046003390 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 365046003391 active site 365046003392 substrate binding site [chemical binding]; other site 365046003393 metal binding site [ion binding]; metal-binding site 365046003394 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 365046003395 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 365046003396 putative active site [active] 365046003397 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 365046003398 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 365046003399 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 365046003400 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 365046003401 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 365046003402 putative metal binding site [ion binding]; other site 365046003403 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 365046003404 putative metal binding site [ion binding]; other site 365046003405 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 365046003406 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 365046003407 active site residue [active] 365046003408 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 365046003409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046003410 S-adenosylmethionine binding site [chemical binding]; other site 365046003411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 365046003412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046003413 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 365046003414 Uncharacterized conserved protein [Function unknown]; Region: COG1434 365046003415 putative active site [active] 365046003416 methionine sulfoxide reductase A; Provisional; Region: PRK14054 365046003417 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 365046003418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046003419 Walker A/P-loop; other site 365046003420 ATP binding site [chemical binding]; other site 365046003421 Q-loop/lid; other site 365046003422 ABC transporter signature motif; other site 365046003423 Walker B; other site 365046003424 D-loop; other site 365046003425 H-loop/switch region; other site 365046003426 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 365046003427 FtsX-like permease family; Region: FtsX; pfam02687 365046003428 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 365046003429 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 365046003430 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 365046003431 N-terminal plug; other site 365046003432 ligand-binding site [chemical binding]; other site 365046003433 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 365046003434 putative addiction module antidote; Region: doc_partner; TIGR02609 365046003435 multidrug efflux system protein; Provisional; Region: PRK11431 365046003436 short chain dehydrogenase; Provisional; Region: PRK06701 365046003437 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 365046003438 NAD binding site [chemical binding]; other site 365046003439 metal binding site [ion binding]; metal-binding site 365046003440 active site 365046003441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046003442 putative active site [active] 365046003443 PAS fold; Region: PAS_3; pfam08447 365046003444 heme pocket [chemical binding]; other site 365046003445 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046003446 GAF domain; Region: GAF; pfam01590 365046003447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046003448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046003449 dimer interface [polypeptide binding]; other site 365046003450 phosphorylation site [posttranslational modification] 365046003451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046003452 ATP binding site [chemical binding]; other site 365046003453 Mg2+ binding site [ion binding]; other site 365046003454 G-X-G motif; other site 365046003455 Response regulator receiver domain; Region: Response_reg; pfam00072 365046003456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003457 active site 365046003458 phosphorylation site [posttranslational modification] 365046003459 intermolecular recognition site; other site 365046003460 dimerization interface [polypeptide binding]; other site 365046003461 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 365046003462 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 365046003463 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 365046003464 Transcriptional regulators [Transcription]; Region: GntR; COG1802 365046003465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046003466 DNA-binding site [nucleotide binding]; DNA binding site 365046003467 FCD domain; Region: FCD; pfam07729 365046003468 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 365046003469 DctM-like transporters; Region: DctM; pfam06808 365046003470 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 365046003471 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046003472 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 365046003473 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 365046003474 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 365046003475 ligand binding site [chemical binding]; other site 365046003476 NAD binding site [chemical binding]; other site 365046003477 catalytic site [active] 365046003478 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 365046003479 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 365046003480 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 365046003481 substrate binding site [chemical binding]; other site 365046003482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046003483 NAD(P) binding site [chemical binding]; other site 365046003484 active site 365046003485 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 365046003486 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 365046003487 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046003488 catalytic loop [active] 365046003489 iron binding site [ion binding]; other site 365046003490 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 365046003491 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 365046003492 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046003493 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 365046003494 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046003495 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046003496 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 365046003497 Ligand binding site; other site 365046003498 metal-binding site 365046003499 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 365046003500 E-class dimer interface [polypeptide binding]; other site 365046003501 P-class dimer interface [polypeptide binding]; other site 365046003502 active site 365046003503 Cu2+ binding site [ion binding]; other site 365046003504 Zn2+ binding site [ion binding]; other site 365046003505 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 365046003506 putative active site pocket [active] 365046003507 dimerization interface [polypeptide binding]; other site 365046003508 putative catalytic residue [active] 365046003509 phosphogluconate dehydratase; Validated; Region: PRK09054 365046003510 6-phosphogluconate dehydratase; Region: edd; TIGR01196 365046003511 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 365046003512 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 365046003513 active site 365046003514 intersubunit interface [polypeptide binding]; other site 365046003515 catalytic residue [active] 365046003516 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 365046003517 putative active site [active] 365046003518 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 365046003519 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 365046003520 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046003521 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 365046003522 dimer interface [polypeptide binding]; other site 365046003523 active site 365046003524 metal binding site [ion binding]; metal-binding site 365046003525 glutathione binding site [chemical binding]; other site 365046003526 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046003527 CoenzymeA binding site [chemical binding]; other site 365046003528 subunit interaction site [polypeptide binding]; other site 365046003529 PHB binding site; other site 365046003530 Transcriptional regulators [Transcription]; Region: MarR; COG1846 365046003531 MarR family; Region: MarR_2; pfam12802 365046003532 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 365046003533 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 365046003534 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 365046003535 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 365046003536 tetramerization interface [polypeptide binding]; other site 365046003537 NAD(P) binding site [chemical binding]; other site 365046003538 catalytic residues [active] 365046003539 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 365046003540 active site 365046003541 catalytic triad [active] 365046003542 oxyanion hole [active] 365046003543 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 365046003544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046003545 NAD(P) binding site [chemical binding]; other site 365046003546 active site 365046003547 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 365046003548 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 365046003549 active site 365046003550 intersubunit interface [polypeptide binding]; other site 365046003551 catalytic residue [active] 365046003552 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 365046003553 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 365046003554 dihydroxy-acid dehydratase; Validated; Region: PRK06131 365046003555 Transcriptional regulators [Transcription]; Region: FadR; COG2186 365046003556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046003557 DNA-binding site [nucleotide binding]; DNA binding site 365046003558 FCD domain; Region: FCD; pfam07729 365046003559 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 365046003560 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 365046003561 DctM-like transporters; Region: DctM; pfam06808 365046003562 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046003563 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 365046003564 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 365046003565 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 365046003566 active site pocket [active] 365046003567 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 365046003568 helicase 45; Provisional; Region: PTZ00424 365046003569 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 365046003570 ATP binding site [chemical binding]; other site 365046003571 Mg++ binding site [ion binding]; other site 365046003572 motif III; other site 365046003573 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046003574 nucleotide binding region [chemical binding]; other site 365046003575 ATP-binding site [chemical binding]; other site 365046003576 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 365046003577 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 365046003578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 365046003579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 365046003580 ABC transporter; Region: ABC_tran_2; pfam12848 365046003581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 365046003582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046003583 AAA domain; Region: AAA_21; pfam13304 365046003584 Walker A/P-loop; other site 365046003585 ATP binding site [chemical binding]; other site 365046003586 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 365046003587 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 365046003588 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 365046003589 Cytochrome c; Region: Cytochrom_C; cl11414 365046003590 Cytochrome c; Region: Cytochrom_C; cl11414 365046003591 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 365046003592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 365046003593 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 365046003594 MarR family; Region: MarR_2; pfam12802 365046003595 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 365046003596 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 365046003597 putative active site pocket [active] 365046003598 cleavage site 365046003599 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 365046003600 metal-binding site [ion binding] 365046003601 tRNA ribose 2'-O-methyltransferase, aTrm56; Region: Trm56; cl17473 365046003602 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 365046003603 metal-binding site [ion binding] 365046003604 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 365046003605 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 365046003606 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 365046003607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046003608 putative substrate translocation pore; other site 365046003609 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 365046003610 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 365046003611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046003612 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 365046003613 acyl-activating enzyme (AAE) consensus motif; other site 365046003614 putative AMP binding site [chemical binding]; other site 365046003615 putative active site [active] 365046003616 putative CoA binding site [chemical binding]; other site 365046003617 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 365046003618 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 365046003619 NADH(P)-binding; Region: NAD_binding_10; pfam13460 365046003620 putative NAD(P) binding site [chemical binding]; other site 365046003621 active site 365046003622 DoxX-like family; Region: DoxX_3; pfam13781 365046003623 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 365046003624 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 365046003625 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 365046003626 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 365046003627 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 365046003628 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 365046003629 active site pocket [active] 365046003630 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 365046003631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046003632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046003633 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 365046003634 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 365046003635 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 365046003636 dinuclear metal binding motif [ion binding]; other site 365046003637 Cupin domain; Region: Cupin_2; cl17218 365046003638 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 365046003639 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 365046003640 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 365046003641 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 365046003642 Domain of unknown function (DUF427); Region: DUF427; pfam04248 365046003643 Biofilm formation and stress response factor; Region: BsmA; pfam10014 365046003644 short chain dehydrogenase; Provisional; Region: PRK07023 365046003645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046003646 NAD(P) binding site [chemical binding]; other site 365046003647 active site 365046003648 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 365046003649 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 365046003650 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 365046003651 active site 365046003652 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 365046003653 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 365046003654 putative acetyltransferase YhhY; Provisional; Region: PRK10140 365046003655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046003656 Coenzyme A binding pocket [chemical binding]; other site 365046003657 TM2 domain; Region: TM2; cl00984 365046003658 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 365046003659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 365046003660 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 365046003661 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 365046003662 RimM N-terminal domain; Region: RimM; pfam01782 365046003663 PRC-barrel domain; Region: PRC; pfam05239 365046003664 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 365046003665 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 365046003666 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 365046003667 putative active site [active] 365046003668 putative CoA binding site [chemical binding]; other site 365046003669 nudix motif; other site 365046003670 metal binding site [ion binding]; metal-binding site 365046003671 CobD/Cbib protein; Region: CobD_Cbib; cl00561 365046003672 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 365046003673 GTPase RsgA; Reviewed; Region: PRK00098 365046003674 RNA binding site [nucleotide binding]; other site 365046003675 homodimer interface [polypeptide binding]; other site 365046003676 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 365046003677 GTPase/Zn-binding domain interface [polypeptide binding]; other site 365046003678 GTP/Mg2+ binding site [chemical binding]; other site 365046003679 G4 box; other site 365046003680 G5 box; other site 365046003681 G1 box; other site 365046003682 Switch I region; other site 365046003683 G2 box; other site 365046003684 G3 box; other site 365046003685 Switch II region; other site 365046003686 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 365046003687 aromatic arch; other site 365046003688 DCoH dimer interaction site [polypeptide binding]; other site 365046003689 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 365046003690 DCoH tetramer interaction site [polypeptide binding]; other site 365046003691 substrate binding site [chemical binding]; other site 365046003692 Peptidase family M48; Region: Peptidase_M48; pfam01435 365046003693 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 365046003694 catalytic site [active] 365046003695 putative active site [active] 365046003696 putative substrate binding site [chemical binding]; other site 365046003697 dimer interface [polypeptide binding]; other site 365046003698 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 365046003699 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 365046003700 ATP binding site [chemical binding]; other site 365046003701 Mg++ binding site [ion binding]; other site 365046003702 motif III; other site 365046003703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046003704 nucleotide binding region [chemical binding]; other site 365046003705 ATP-binding site [chemical binding]; other site 365046003706 Transcriptional regulator [Transcription]; Region: IclR; COG1414 365046003707 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 365046003708 Bacterial transcriptional regulator; Region: IclR; pfam01614 365046003709 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 365046003710 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 365046003711 putative ligand binding site [chemical binding]; other site 365046003712 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046003713 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046003714 Walker A/P-loop; other site 365046003715 ATP binding site [chemical binding]; other site 365046003716 Q-loop/lid; other site 365046003717 ABC transporter signature motif; other site 365046003718 Walker B; other site 365046003719 D-loop; other site 365046003720 H-loop/switch region; other site 365046003721 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046003722 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046003723 Walker A/P-loop; other site 365046003724 ATP binding site [chemical binding]; other site 365046003725 Q-loop/lid; other site 365046003726 ABC transporter signature motif; other site 365046003727 Walker B; other site 365046003728 D-loop; other site 365046003729 H-loop/switch region; other site 365046003730 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 365046003731 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046003732 TM-ABC transporter signature motif; other site 365046003733 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046003734 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046003735 TM-ABC transporter signature motif; other site 365046003736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046003737 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 365046003738 putative substrate translocation pore; other site 365046003739 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 365046003740 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 365046003741 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 365046003742 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 365046003743 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 365046003744 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 365046003745 Response regulator receiver domain; Region: Response_reg; pfam00072 365046003746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003747 active site 365046003748 phosphorylation site [posttranslational modification] 365046003749 intermolecular recognition site; other site 365046003750 dimerization interface [polypeptide binding]; other site 365046003751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046003752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046003753 dimer interface [polypeptide binding]; other site 365046003754 phosphorylation site [posttranslational modification] 365046003755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046003756 ATP binding site [chemical binding]; other site 365046003757 Mg2+ binding site [ion binding]; other site 365046003758 G-X-G motif; other site 365046003759 Response regulator receiver domain; Region: Response_reg; pfam00072 365046003760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003761 active site 365046003762 phosphorylation site [posttranslational modification] 365046003763 intermolecular recognition site; other site 365046003764 dimerization interface [polypeptide binding]; other site 365046003765 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 365046003766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003767 dimerization interface [polypeptide binding]; other site 365046003768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003769 dimerization interface [polypeptide binding]; other site 365046003770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003771 dimerization interface [polypeptide binding]; other site 365046003772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003773 dimerization interface [polypeptide binding]; other site 365046003774 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 365046003775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003776 dimerization interface [polypeptide binding]; other site 365046003777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003778 dimerization interface [polypeptide binding]; other site 365046003779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003780 dimerization interface [polypeptide binding]; other site 365046003781 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 365046003782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003783 dimerization interface [polypeptide binding]; other site 365046003784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003785 dimerization interface [polypeptide binding]; other site 365046003786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003787 dimerization interface [polypeptide binding]; other site 365046003788 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 365046003789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003790 dimerization interface [polypeptide binding]; other site 365046003791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003792 dimerization interface [polypeptide binding]; other site 365046003793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003794 dimerization interface [polypeptide binding]; other site 365046003795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046003796 dimerization interface [polypeptide binding]; other site 365046003797 GAF domain; Region: GAF; cl17456 365046003798 GAF domain; Region: GAF_2; pfam13185 365046003799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046003800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046003801 dimer interface [polypeptide binding]; other site 365046003802 phosphorylation site [posttranslational modification] 365046003803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046003804 ATP binding site [chemical binding]; other site 365046003805 Mg2+ binding site [ion binding]; other site 365046003806 G-X-G motif; other site 365046003807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003808 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 365046003809 active site 365046003810 phosphorylation site [posttranslational modification] 365046003811 intermolecular recognition site; other site 365046003812 dimerization interface [polypeptide binding]; other site 365046003813 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046003814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003815 active site 365046003816 phosphorylation site [posttranslational modification] 365046003817 intermolecular recognition site; other site 365046003818 dimerization interface [polypeptide binding]; other site 365046003819 Response regulator receiver domain; Region: Response_reg; pfam00072 365046003820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003821 active site 365046003822 phosphorylation site [posttranslational modification] 365046003823 intermolecular recognition site; other site 365046003824 dimerization interface [polypeptide binding]; other site 365046003825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046003826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046003827 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 365046003828 putative effector binding pocket; other site 365046003829 putative dimerization interface [polypeptide binding]; other site 365046003830 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046003831 galactonate dehydratase; Provisional; Region: PRK14017 365046003832 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 365046003833 active site pocket [active] 365046003834 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046003835 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 365046003836 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 365046003837 active site 365046003838 putative substrate binding pocket [chemical binding]; other site 365046003839 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 365046003840 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 365046003841 dimer interface [polypeptide binding]; other site 365046003842 active site 365046003843 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 365046003844 substrate binding site [chemical binding]; other site 365046003845 catalytic residue [active] 365046003846 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046003847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046003848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046003849 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 365046003850 putative dimerization interface [polypeptide binding]; other site 365046003851 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046003852 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 365046003853 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046003854 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 365046003855 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 365046003856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 365046003857 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 365046003858 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 365046003859 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 365046003860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046003861 ATP binding site [chemical binding]; other site 365046003862 putative Mg++ binding site [ion binding]; other site 365046003863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 365046003864 nucleotide binding region [chemical binding]; other site 365046003865 ATP-binding site [chemical binding]; other site 365046003866 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 365046003867 HsdM N-terminal domain; Region: HsdM_N; pfam12161 365046003868 Methyltransferase domain; Region: Methyltransf_26; pfam13659 365046003869 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 365046003870 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 365046003871 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 365046003872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046003873 Walker A motif; other site 365046003874 ATP binding site [chemical binding]; other site 365046003875 Walker B motif; other site 365046003876 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 365046003877 Secretin and TonB N terminus short domain; Region: STN; smart00965 365046003878 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 365046003879 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 365046003880 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 365046003881 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 365046003882 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 365046003883 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 365046003884 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 365046003885 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 365046003886 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 365046003887 Walker A motif; other site 365046003888 ATP binding site [chemical binding]; other site 365046003889 Walker B motif; other site 365046003890 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 365046003891 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 365046003892 Actin-rearrangement-inducing factor (Arif-1); Region: Arif-1; pfam06770 365046003893 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 365046003894 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 365046003895 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 365046003896 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 365046003897 RHS Repeat; Region: RHS_repeat; pfam05593 365046003898 RHS Repeat; Region: RHS_repeat; pfam05593 365046003899 RHS Repeat; Region: RHS_repeat; pfam05593 365046003900 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 365046003901 RHS Repeat; Region: RHS_repeat; cl11982 365046003902 RHS Repeat; Region: RHS_repeat; pfam05593 365046003903 RHS Repeat; Region: RHS_repeat; cl11982 365046003904 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 365046003905 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 365046003906 RHS Repeat; Region: RHS_repeat; pfam05593 365046003907 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 365046003908 Predicted ATPase [General function prediction only]; Region: COG3910 365046003909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046003910 Walker A/P-loop; other site 365046003911 ATP binding site [chemical binding]; other site 365046003912 Q-loop/lid; other site 365046003913 ABC transporter signature motif; other site 365046003914 Walker B; other site 365046003915 D-loop; other site 365046003916 H-loop/switch region; other site 365046003917 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 365046003918 RHS Repeat; Region: RHS_repeat; cl11982 365046003919 RHS Repeat; Region: RHS_repeat; pfam05593 365046003920 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 365046003921 hypothetical protein; Provisional; Region: PRK06208 365046003922 intersubunit interface [polypeptide binding]; other site 365046003923 active site 365046003924 Zn2+ binding site [ion binding]; other site 365046003925 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 365046003926 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 365046003927 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 365046003928 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 365046003929 Transcriptional regulators [Transcription]; Region: GntR; COG1802 365046003930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046003931 DNA-binding site [nucleotide binding]; DNA binding site 365046003932 FCD domain; Region: FCD; pfam07729 365046003933 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 365046003934 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 365046003935 substrate binding pocket [chemical binding]; other site 365046003936 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 365046003937 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 365046003938 active site 365046003939 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 365046003940 Part of AAA domain; Region: AAA_19; pfam13245 365046003941 Family description; Region: UvrD_C_2; pfam13538 365046003942 Response regulator receiver domain; Region: Response_reg; pfam00072 365046003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003944 active site 365046003945 phosphorylation site [posttranslational modification] 365046003946 intermolecular recognition site; other site 365046003947 dimerization interface [polypeptide binding]; other site 365046003948 histidine kinase; Provisional; Region: PRK13557 365046003949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046003950 putative active site [active] 365046003951 heme pocket [chemical binding]; other site 365046003952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046003953 dimer interface [polypeptide binding]; other site 365046003954 phosphorylation site [posttranslational modification] 365046003955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046003956 ATP binding site [chemical binding]; other site 365046003957 Mg2+ binding site [ion binding]; other site 365046003958 G-X-G motif; other site 365046003959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046003960 active site 365046003961 phosphorylation site [posttranslational modification] 365046003962 intermolecular recognition site; other site 365046003963 dimerization interface [polypeptide binding]; other site 365046003964 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 365046003965 Phosphotransferase enzyme family; Region: APH; pfam01636 365046003966 putative active site [active] 365046003967 putative substrate binding site [chemical binding]; other site 365046003968 ATP binding site [chemical binding]; other site 365046003969 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 365046003970 DNA polymerase I; Provisional; Region: PRK05755 365046003971 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 365046003972 active site 365046003973 metal binding site 1 [ion binding]; metal-binding site 365046003974 putative 5' ssDNA interaction site; other site 365046003975 metal binding site 3; metal-binding site 365046003976 metal binding site 2 [ion binding]; metal-binding site 365046003977 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 365046003978 putative DNA binding site [nucleotide binding]; other site 365046003979 putative metal binding site [ion binding]; other site 365046003980 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 365046003981 active site 365046003982 catalytic site [active] 365046003983 substrate binding site [chemical binding]; other site 365046003984 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 365046003985 active site 365046003986 DNA binding site [nucleotide binding] 365046003987 catalytic site [active] 365046003988 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 365046003989 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 365046003990 active site 1 [active] 365046003991 dimer interface [polypeptide binding]; other site 365046003992 hexamer interface [polypeptide binding]; other site 365046003993 active site 2 [active] 365046003994 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 365046003995 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 365046003996 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 365046003997 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 365046003998 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 365046003999 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 365046004000 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 365046004001 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046004002 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046004003 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 365046004004 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 365046004005 Hemerythrin-like domain; Region: Hr-like; cd12108 365046004006 Fe binding site [ion binding]; other site 365046004007 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 365046004008 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 365046004009 active site residue [active] 365046004010 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 365046004011 active site residue [active] 365046004012 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 365046004013 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 365046004014 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 365046004015 [2Fe-2S] cluster binding site [ion binding]; other site 365046004016 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 365046004017 alpha subunit interface [polypeptide binding]; other site 365046004018 active site 365046004019 substrate binding site [chemical binding]; other site 365046004020 Fe binding site [ion binding]; other site 365046004021 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 365046004022 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 365046004023 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 365046004024 substrate binding pocket [chemical binding]; other site 365046004025 chain length determination region; other site 365046004026 substrate-Mg2+ binding site; other site 365046004027 catalytic residues [active] 365046004028 aspartate-rich region 1; other site 365046004029 active site lid residues [active] 365046004030 aspartate-rich region 2; other site 365046004031 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 365046004032 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 365046004033 TPP-binding site; other site 365046004034 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 365046004035 PYR/PP interface [polypeptide binding]; other site 365046004036 dimer interface [polypeptide binding]; other site 365046004037 TPP binding site [chemical binding]; other site 365046004038 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 365046004039 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 365046004040 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046004041 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 365046004042 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046004043 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 365046004044 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 365046004045 Domain of unknown function DUF21; Region: DUF21; pfam01595 365046004046 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 365046004047 Transporter associated domain; Region: CorC_HlyC; smart01091 365046004048 putative cation:proton antiport protein; Provisional; Region: PRK10669 365046004049 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 365046004050 TrkA-N domain; Region: TrkA_N; pfam02254 365046004051 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 365046004052 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 365046004053 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 365046004054 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 365046004055 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 365046004056 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 365046004057 PLD-like domain; Region: PLDc_2; pfam13091 365046004058 putative active site [active] 365046004059 catalytic site [active] 365046004060 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 365046004061 PLD-like domain; Region: PLDc_2; pfam13091 365046004062 putative active site [active] 365046004063 catalytic site [active] 365046004064 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 365046004065 PBP superfamily domain; Region: PBP_like; pfam12727 365046004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 365046004067 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 365046004068 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 365046004069 Walker A/P-loop; other site 365046004070 ATP binding site [chemical binding]; other site 365046004071 Q-loop/lid; other site 365046004072 ABC transporter signature motif; other site 365046004073 Walker B; other site 365046004074 D-loop; other site 365046004075 H-loop/switch region; other site 365046004076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 365046004077 dimerization interface [polypeptide binding]; other site 365046004078 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 365046004079 Putative Ig domain; Region: He_PIG; pfam05345 365046004080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 365046004081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046004082 Coenzyme A binding pocket [chemical binding]; other site 365046004083 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 365046004084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046004085 Walker A/P-loop; other site 365046004086 ATP binding site [chemical binding]; other site 365046004087 Q-loop/lid; other site 365046004088 ABC transporter signature motif; other site 365046004089 Walker B; other site 365046004090 D-loop; other site 365046004091 H-loop/switch region; other site 365046004092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046004093 dimer interface [polypeptide binding]; other site 365046004094 ABC-ATPase subunit interface; other site 365046004095 putative PBP binding loops; other site 365046004096 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 365046004097 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 365046004098 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 365046004099 TOBE domain; Region: TOBE; cl01440 365046004100 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 365046004101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046004102 heme pocket [chemical binding]; other site 365046004103 putative active site [active] 365046004104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046004105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046004106 dimer interface [polypeptide binding]; other site 365046004107 phosphorylation site [posttranslational modification] 365046004108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046004109 ATP binding site [chemical binding]; other site 365046004110 Mg2+ binding site [ion binding]; other site 365046004111 G-X-G motif; other site 365046004112 Response regulator receiver domain; Region: Response_reg; pfam00072 365046004113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046004114 active site 365046004115 phosphorylation site [posttranslational modification] 365046004116 intermolecular recognition site; other site 365046004117 dimerization interface [polypeptide binding]; other site 365046004118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046004119 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 365046004120 putative active site [active] 365046004121 heme pocket [chemical binding]; other site 365046004122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046004123 dimer interface [polypeptide binding]; other site 365046004124 phosphorylation site [posttranslational modification] 365046004125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046004126 ATP binding site [chemical binding]; other site 365046004127 Mg2+ binding site [ion binding]; other site 365046004128 G-X-G motif; other site 365046004129 Response regulator receiver domain; Region: Response_reg; pfam00072 365046004130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046004131 active site 365046004132 phosphorylation site [posttranslational modification] 365046004133 intermolecular recognition site; other site 365046004134 dimerization interface [polypeptide binding]; other site 365046004135 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 365046004136 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 365046004137 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046004138 catalytic loop [active] 365046004139 iron binding site [ion binding]; other site 365046004140 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 365046004141 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 365046004142 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 365046004143 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046004144 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 365046004145 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 365046004146 MoxR-like ATPases [General function prediction only]; Region: COG0714 365046004147 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 365046004148 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 365046004149 putative hydrophobic ligand binding site [chemical binding]; other site 365046004150 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 365046004151 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 365046004152 N-terminal plug; other site 365046004153 ligand-binding site [chemical binding]; other site 365046004154 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 365046004155 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 365046004156 XdhC Rossmann domain; Region: XdhC_C; pfam13478 365046004157 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 365046004158 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 365046004159 ligand binding site [chemical binding]; other site 365046004160 flexible hinge region; other site 365046004161 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 365046004162 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 365046004163 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046004164 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046004165 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 365046004166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046004167 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 365046004168 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 365046004169 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 365046004170 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046004171 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 365046004172 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 365046004173 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 365046004174 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 365046004175 DctM-like transporters; Region: DctM; pfam06808 365046004176 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 365046004177 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 365046004178 5-oxoprolinase; Region: PLN02666 365046004179 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 365046004180 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 365046004181 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 365046004182 DinB family; Region: DinB; cl17821 365046004183 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 365046004184 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 365046004185 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 365046004186 NADP binding site [chemical binding]; other site 365046004187 homopentamer interface [polypeptide binding]; other site 365046004188 substrate binding site [chemical binding]; other site 365046004189 active site 365046004190 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 365046004191 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 365046004192 putative ribose interaction site [chemical binding]; other site 365046004193 putative ADP binding site [chemical binding]; other site 365046004194 tetratricopeptide repeat protein; Provisional; Region: PRK11788 365046004195 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 365046004196 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 365046004197 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 365046004198 IHF dimer interface [polypeptide binding]; other site 365046004199 IHF - DNA interface [nucleotide binding]; other site 365046004200 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 365046004201 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 365046004202 RNA binding site [nucleotide binding]; other site 365046004203 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 365046004204 RNA binding site [nucleotide binding]; other site 365046004205 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 365046004206 RNA binding site [nucleotide binding]; other site 365046004207 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 365046004208 RNA binding site [nucleotide binding]; other site 365046004209 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 365046004210 RNA binding site [nucleotide binding]; other site 365046004211 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 365046004212 RNA binding site [nucleotide binding]; other site 365046004213 bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860 365046004214 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 365046004215 hinge; other site 365046004216 active site 365046004217 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 365046004218 CMP-binding site; other site 365046004219 The sites determining sugar specificity; other site 365046004220 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 365046004221 prephenate dehydrogenase; Validated; Region: PRK08507 365046004222 Chorismate mutase type II; Region: CM_2; cl00693 365046004223 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 365046004224 Prephenate dehydratase; Region: PDT; pfam00800 365046004225 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 365046004226 putative L-Phe binding site [chemical binding]; other site 365046004227 DNA gyrase subunit A; Validated; Region: PRK05560 365046004228 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 365046004229 CAP-like domain; other site 365046004230 active site 365046004231 primary dimer interface [polypeptide binding]; other site 365046004232 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 365046004233 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 365046004234 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 365046004235 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 365046004236 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 365046004237 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 365046004238 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 365046004239 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 365046004240 ligand binding site [chemical binding]; other site 365046004241 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 365046004242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046004243 S-adenosylmethionine binding site [chemical binding]; other site 365046004244 phosphoglycolate phosphatase; Provisional; Region: PRK13222 365046004245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046004246 motif II; other site 365046004247 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 365046004248 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 365046004249 putative substrate binding site [chemical binding]; other site 365046004250 putative ATP binding site [chemical binding]; other site 365046004251 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 365046004252 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 365046004253 Cytochrome c; Region: Cytochrom_C; cl11414 365046004254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046004255 dimerization interface [polypeptide binding]; other site 365046004256 putative DNA binding site [nucleotide binding]; other site 365046004257 putative Zn2+ binding site [ion binding]; other site 365046004258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 365046004259 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 365046004260 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 365046004261 Moco binding site; other site 365046004262 metal coordination site [ion binding]; other site 365046004263 Cytochrome c; Region: Cytochrom_C; pfam00034 365046004264 Cytochrome c; Region: Cytochrom_C; cl11414 365046004265 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 365046004266 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 365046004267 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 365046004268 Cytochrome c [Energy production and conversion]; Region: COG3258 365046004269 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 365046004270 active site 365046004271 metal binding site [ion binding]; metal-binding site 365046004272 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 365046004273 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 365046004274 Domain of unknown function (DUF336); Region: DUF336; pfam03928 365046004275 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 365046004276 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 365046004277 ATP phosphoribosyltransferase; Region: HisG; cl15266 365046004278 short chain dehydrogenase; Provisional; Region: PRK06482 365046004279 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 365046004280 NADP binding site [chemical binding]; other site 365046004281 active site 365046004282 steroid binding site; other site 365046004283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046004284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046004285 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 365046004286 putative effector binding pocket; other site 365046004287 putative dimerization interface [polypeptide binding]; other site 365046004288 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 365046004289 MarR family; Region: MarR; pfam01047 365046004290 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 365046004291 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 365046004292 dimer interface [polypeptide binding]; other site 365046004293 PYR/PP interface [polypeptide binding]; other site 365046004294 TPP binding site [chemical binding]; other site 365046004295 substrate binding site [chemical binding]; other site 365046004296 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 365046004297 TPP-binding site; other site 365046004298 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 365046004299 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 365046004300 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 365046004301 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 365046004302 FAD binding pocket [chemical binding]; other site 365046004303 FAD binding motif [chemical binding]; other site 365046004304 phosphate binding motif [ion binding]; other site 365046004305 beta-alpha-beta structure motif; other site 365046004306 NAD binding pocket [chemical binding]; other site 365046004307 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 365046004308 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 365046004309 ligand binding site [chemical binding]; other site 365046004310 NAD binding site [chemical binding]; other site 365046004311 dimerization interface [polypeptide binding]; other site 365046004312 catalytic site [active] 365046004313 hypothetical protein; Validated; Region: PRK06201 365046004314 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 365046004315 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046004316 Transcriptional regulator [Transcription]; Region: IclR; COG1414 365046004317 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 365046004318 Bacterial transcriptional regulator; Region: IclR; pfam01614 365046004319 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 365046004320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 365046004321 substrate binding pocket [chemical binding]; other site 365046004322 membrane-bound complex binding site; other site 365046004323 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 365046004324 tetramer interface [polypeptide binding]; other site 365046004325 Predicted amidohydrolase [General function prediction only]; Region: COG0388 365046004326 active site 365046004327 catalytic triad [active] 365046004328 dimer interface [polypeptide binding]; other site 365046004329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046004330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046004331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046004332 dimerization interface [polypeptide binding]; other site 365046004333 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046004334 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 365046004335 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 365046004336 active site 365046004337 putative substrate binding pocket [chemical binding]; other site 365046004338 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046004339 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 365046004340 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 365046004341 YCII-related domain; Region: YCII; cl00999 365046004342 Transcriptional regulator [Transcription]; Region: IclR; COG1414 365046004343 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 365046004344 Bacterial transcriptional regulator; Region: IclR; pfam01614 365046004345 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046004346 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 365046004347 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046004348 substrate binding site [chemical binding]; other site 365046004349 oxyanion hole (OAH) forming residues; other site 365046004350 trimer interface [polypeptide binding]; other site 365046004351 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 365046004352 CoA binding domain; Region: CoA_binding_2; pfam13380 365046004353 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 365046004354 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 365046004355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046004356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046004357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046004358 dimerization interface [polypeptide binding]; other site 365046004359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046004360 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046004361 active site 365046004362 Cupin domain; Region: Cupin_2; pfam07883 365046004363 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046004364 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046004366 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046004367 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046004368 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 365046004369 Uncharacterized conserved protein [Function unknown]; Region: COG3777 365046004370 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 365046004371 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 365046004372 active site 2 [active] 365046004373 active site 1 [active] 365046004374 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046004375 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 365046004376 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 365046004377 active site 365046004378 Transcriptional regulator [Transcription]; Region: IclR; COG1414 365046004379 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 365046004380 Bacterial transcriptional regulator; Region: IclR; pfam01614 365046004381 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 365046004382 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046004383 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 365046004384 active site 365046004385 catalytic residues [active] 365046004386 metal binding site [ion binding]; metal-binding site 365046004387 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046004388 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046004389 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 365046004390 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046004391 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 365046004392 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 365046004393 PYR/PP interface [polypeptide binding]; other site 365046004394 dimer interface [polypeptide binding]; other site 365046004395 TPP binding site [chemical binding]; other site 365046004396 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 365046004397 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 365046004398 TPP-binding site [chemical binding]; other site 365046004399 Transcriptional regulators [Transcription]; Region: GntR; COG1802 365046004400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046004401 DNA-binding site [nucleotide binding]; DNA binding site 365046004402 FCD domain; Region: FCD; pfam07729 365046004403 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 365046004404 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 365046004405 NADP binding site [chemical binding]; other site 365046004406 active site 365046004407 steroid binding site; other site 365046004408 short chain dehydrogenase; Provisional; Region: PRK12937 365046004409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046004410 NAD(P) binding site [chemical binding]; other site 365046004411 active site 365046004412 transcriptional regulator; Provisional; Region: PRK10632 365046004413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046004414 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 365046004415 putative effector binding pocket; other site 365046004416 putative dimerization interface [polypeptide binding]; other site 365046004417 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 365046004418 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 365046004419 RNA binding surface [nucleotide binding]; other site 365046004420 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 365046004421 active site 365046004422 uracil binding [chemical binding]; other site 365046004423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046004424 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 365046004425 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 365046004426 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 365046004427 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 365046004428 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 365046004429 NodB motif; other site 365046004430 active site 365046004431 catalytic site [active] 365046004432 metal binding site [ion binding]; metal-binding site 365046004433 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 365046004434 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 365046004435 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 365046004436 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 365046004437 putative MPT binding site; other site 365046004438 glutamine synthetase; Provisional; Region: glnA; PRK09469 365046004439 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 365046004440 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 365046004441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046004442 dimer interface [polypeptide binding]; other site 365046004443 phosphorylation site [posttranslational modification] 365046004444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046004445 ATP binding site [chemical binding]; other site 365046004446 Mg2+ binding site [ion binding]; other site 365046004447 G-X-G motif; other site 365046004448 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 365046004449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046004450 active site 365046004451 phosphorylation site [posttranslational modification] 365046004452 intermolecular recognition site; other site 365046004453 dimerization interface [polypeptide binding]; other site 365046004454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046004455 Walker A motif; other site 365046004456 ATP binding site [chemical binding]; other site 365046004457 Walker B motif; other site 365046004458 arginine finger; other site 365046004459 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 365046004460 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 365046004461 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 365046004462 putative catalytic site [active] 365046004463 putative phosphate binding site [ion binding]; other site 365046004464 active site 365046004465 metal binding site A [ion binding]; metal-binding site 365046004466 DNA binding site [nucleotide binding] 365046004467 putative AP binding site [nucleotide binding]; other site 365046004468 putative metal binding site B [ion binding]; other site 365046004469 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 365046004470 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 365046004471 folate binding site [chemical binding]; other site 365046004472 NADP+ binding site [chemical binding]; other site 365046004473 thymidylate synthase; Reviewed; Region: thyA; PRK01827 365046004474 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 365046004475 dimerization interface [polypeptide binding]; other site 365046004476 active site 365046004477 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 365046004478 FAD binding domain; Region: FAD_binding_4; pfam01565 365046004479 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 365046004480 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 365046004481 Protein of unknown function (DUF962); Region: DUF962; cl01879 365046004482 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 365046004483 Cytochrome P450; Region: p450; cl12078 365046004484 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046004485 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 365046004486 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 365046004487 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 365046004488 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 365046004489 homodimer interface [polypeptide binding]; other site 365046004490 substrate-cofactor binding pocket; other site 365046004491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046004492 catalytic residue [active] 365046004493 FOG: CBS domain [General function prediction only]; Region: COG0517 365046004494 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 365046004495 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 365046004496 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 365046004497 Tetramer interface [polypeptide binding]; other site 365046004498 active site 365046004499 FMN-binding site [chemical binding]; other site 365046004500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046004501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046004502 putative substrate translocation pore; other site 365046004503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046004504 PAS domain; Region: PAS_9; pfam13426 365046004505 putative active site [active] 365046004506 heme pocket [chemical binding]; other site 365046004507 PAS fold; Region: PAS_3; pfam08447 365046004508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046004509 heme pocket [chemical binding]; other site 365046004510 putative active site [active] 365046004511 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046004512 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 365046004513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046004514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046004515 dimer interface [polypeptide binding]; other site 365046004516 phosphorylation site [posttranslational modification] 365046004517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046004518 ATP binding site [chemical binding]; other site 365046004519 Mg2+ binding site [ion binding]; other site 365046004520 G-X-G motif; other site 365046004521 Response regulator receiver domain; Region: Response_reg; pfam00072 365046004522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046004523 active site 365046004524 phosphorylation site [posttranslational modification] 365046004525 intermolecular recognition site; other site 365046004526 dimerization interface [polypeptide binding]; other site 365046004527 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 365046004528 putative metal binding site [ion binding]; other site 365046004529 short chain dehydrogenase; Provisional; Region: PRK06701 365046004530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046004531 NAD(P) binding site [chemical binding]; other site 365046004532 active site 365046004533 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 365046004534 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 365046004535 catalytic residues [active] 365046004536 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046004537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046004538 active site 365046004539 phosphorylation site [posttranslational modification] 365046004540 intermolecular recognition site; other site 365046004541 dimerization interface [polypeptide binding]; other site 365046004542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046004543 Response regulator receiver domain; Region: Response_reg; pfam00072 365046004544 active site 365046004545 phosphorylation site [posttranslational modification] 365046004546 intermolecular recognition site; other site 365046004547 dimerization interface [polypeptide binding]; other site 365046004548 glycine dehydrogenase; Provisional; Region: PRK05367 365046004549 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 365046004550 tetramer interface [polypeptide binding]; other site 365046004551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046004552 catalytic residue [active] 365046004553 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 365046004554 tetramer interface [polypeptide binding]; other site 365046004555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046004556 catalytic residue [active] 365046004557 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 365046004558 lipoyl attachment site [posttranslational modification]; other site 365046004559 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 365046004560 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 365046004561 DctM-like transporters; Region: DctM; pfam06808 365046004562 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 365046004563 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 365046004564 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046004565 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 365046004566 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 365046004567 hydroxyglutarate oxidase; Provisional; Region: PRK11728 365046004568 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 365046004569 short chain dehydrogenase; Provisional; Region: PRK06949 365046004570 classical (c) SDRs; Region: SDR_c; cd05233 365046004571 NAD(P) binding site [chemical binding]; other site 365046004572 active site 365046004573 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 365046004574 active site 365046004575 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 365046004576 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 365046004577 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 365046004578 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 365046004579 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 365046004580 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 365046004581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046004582 PAS domain; Region: PAS_9; pfam13426 365046004583 putative active site [active] 365046004584 heme pocket [chemical binding]; other site 365046004585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046004586 DNA binding residues [nucleotide binding] 365046004587 dimerization interface [polypeptide binding]; other site 365046004588 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 365046004589 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 365046004590 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 365046004591 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 365046004592 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 365046004593 active site 365046004594 DNA binding site [nucleotide binding] 365046004595 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 365046004596 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 365046004597 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 365046004598 Walker A/P-loop; other site 365046004599 ATP binding site [chemical binding]; other site 365046004600 Q-loop/lid; other site 365046004601 ABC transporter signature motif; other site 365046004602 Walker B; other site 365046004603 D-loop; other site 365046004604 H-loop/switch region; other site 365046004605 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 365046004606 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 365046004607 Uncharacterized conserved protein [Function unknown]; Region: COG4544 365046004608 Y-family of DNA polymerases; Region: PolY; cl12025 365046004609 DNA binding site [nucleotide binding] 365046004610 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 365046004611 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 365046004612 putative active site [active] 365046004613 putative PHP Thumb interface [polypeptide binding]; other site 365046004614 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 365046004615 generic binding surface II; other site 365046004616 generic binding surface I; other site 365046004617 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 365046004618 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 365046004619 Moco binding site; other site 365046004620 metal coordination site [ion binding]; other site 365046004621 dimerization interface [polypeptide binding]; other site 365046004622 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 365046004623 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 365046004624 active site residue [active] 365046004625 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 365046004626 substrate binding site [chemical binding]; other site 365046004627 potential protein location (conserved hypothetical protein [Ramlibacter tataouinensis TTB310]) that overlaps RNA (tRNA-G) 365046004628 Conserved TM helix; Region: TM_helix; pfam05552 365046004629 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 365046004630 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 365046004631 motif 1; other site 365046004632 active site 365046004633 motif 2; other site 365046004634 motif 3; other site 365046004635 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 365046004636 DHHA1 domain; Region: DHHA1; pfam02272 365046004637 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 365046004638 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 365046004639 active site 365046004640 KMSKS motif; other site 365046004641 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 365046004642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 365046004643 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 365046004644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046004645 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046004646 dimerization interface [polypeptide binding]; other site 365046004647 Pirin-related protein [General function prediction only]; Region: COG1741 365046004648 Pirin; Region: Pirin; pfam02678 365046004649 Planctomycetes uncharacterized domain TIGR03000; Region: plancto_dom_1 365046004650 Predicted membrane protein [Function unknown]; Region: COG2259 365046004651 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 365046004652 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 365046004653 Pirin-related protein [General function prediction only]; Region: COG1741 365046004654 Pirin; Region: Pirin; pfam02678 365046004655 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 365046004656 Protein of unknown function, DUF599; Region: DUF599; pfam04654 365046004657 rhodanese superfamily protein; Provisional; Region: PRK05320 365046004658 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 365046004659 active site residue [active] 365046004660 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 365046004661 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 365046004662 putative active site [active] 365046004663 putative PHP Thumb interface [polypeptide binding]; other site 365046004664 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 365046004665 generic binding surface II; other site 365046004666 generic binding surface I; other site 365046004667 TonB C terminal; Region: TonB_2; pfam13103 365046004668 TolA protein; Region: tolA_full; TIGR02794 365046004669 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 365046004670 TolR protein; Region: tolR; TIGR02801 365046004671 TolQ protein; Region: tolQ; TIGR02796 365046004672 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 365046004673 active site 365046004674 aminotransferase; Validated; Region: PRK07337 365046004675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046004676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046004677 homodimer interface [polypeptide binding]; other site 365046004678 catalytic residue [active] 365046004679 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 365046004680 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 365046004681 homopentamer interface [polypeptide binding]; other site 365046004682 active site 365046004683 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 365046004684 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 365046004685 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 365046004686 dimerization interface [polypeptide binding]; other site 365046004687 active site 365046004688 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 365046004689 Lumazine binding domain; Region: Lum_binding; pfam00677 365046004690 Lumazine binding domain; Region: Lum_binding; pfam00677 365046004691 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 365046004692 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 365046004693 catalytic motif [active] 365046004694 Zn binding site [ion binding]; other site 365046004695 RibD C-terminal domain; Region: RibD_C; cl17279 365046004696 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 365046004697 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 365046004698 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 365046004699 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 365046004700 PilX N-terminal; Region: PilX_N; pfam14341 365046004701 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 365046004702 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 365046004703 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 365046004704 Type II transport protein GspH; Region: GspH; pfam12019 365046004705 Type II transport protein GspH; Region: GspH; pfam12019 365046004706 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 365046004707 ATP cone domain; Region: ATP-cone; pfam03477 365046004708 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 365046004709 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 365046004710 dimer interface [polypeptide binding]; other site 365046004711 active site 365046004712 glycine-pyridoxal phosphate binding site [chemical binding]; other site 365046004713 folate binding site [chemical binding]; other site 365046004714 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 365046004715 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 365046004716 N-acetyl-D-glucosamine binding site [chemical binding]; other site 365046004717 catalytic residue [active] 365046004718 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 365046004719 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 365046004720 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 365046004721 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 365046004722 putative active site [active] 365046004723 putative metal binding site [ion binding]; other site 365046004724 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 365046004725 substrate binding site [chemical binding]; other site 365046004726 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 365046004727 active site 365046004728 TPR repeat; Region: TPR_11; pfam13414 365046004729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 365046004730 binding surface 365046004731 TPR motif; other site 365046004732 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 365046004733 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 365046004734 active site 365046004735 HIGH motif; other site 365046004736 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 365046004737 KMSKS motif; other site 365046004738 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 365046004739 tRNA binding surface [nucleotide binding]; other site 365046004740 anticodon binding site; other site 365046004741 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 365046004742 endonuclease III; Region: ENDO3c; smart00478 365046004743 minor groove reading motif; other site 365046004744 helix-hairpin-helix signature motif; other site 365046004745 substrate binding pocket [chemical binding]; other site 365046004746 active site 365046004747 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 365046004748 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 365046004749 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 365046004750 Ligand Binding Site [chemical binding]; other site 365046004751 TilS substrate binding domain; Region: TilS; pfam09179 365046004752 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046004753 aspartate kinase; Reviewed; Region: PRK06635 365046004754 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 365046004755 putative Mg ion binding site [ion binding]; other site 365046004756 putative aspartate binding site [chemical binding]; other site 365046004757 putative catalytic residues [active] 365046004758 putative nucleotide binding site [chemical binding]; other site 365046004759 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 365046004760 putative allosteric regulatory site; other site 365046004761 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 365046004762 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 365046004763 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 365046004764 metal binding site [ion binding]; metal-binding site 365046004765 putative dimer interface [polypeptide binding]; other site 365046004766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046004767 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 365046004768 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 365046004769 substrate binding site [chemical binding]; other site 365046004770 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 365046004771 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 365046004772 substrate binding site [chemical binding]; other site 365046004773 ligand binding site [chemical binding]; other site 365046004774 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 365046004775 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 365046004776 tetramer interface [polypeptide binding]; other site 365046004777 active site 365046004778 Mg2+/Mn2+ binding site [ion binding]; other site 365046004779 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046004780 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 365046004781 RNA binding surface [nucleotide binding]; other site 365046004782 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 365046004783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046004784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046004785 dimer interface [polypeptide binding]; other site 365046004786 phosphorylation site [posttranslational modification] 365046004787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046004788 ATP binding site [chemical binding]; other site 365046004789 Mg2+ binding site [ion binding]; other site 365046004790 G-X-G motif; other site 365046004791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 365046004792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046004793 active site 365046004794 phosphorylation site [posttranslational modification] 365046004795 intermolecular recognition site; other site 365046004796 dimerization interface [polypeptide binding]; other site 365046004797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046004798 DNA binding site [nucleotide binding] 365046004799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046004800 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 365046004801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 365046004802 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 365046004803 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 365046004804 putative active site [active] 365046004805 catalytic site [active] 365046004806 putative metal binding site [ion binding]; other site 365046004807 PAS domain; Region: PAS; smart00091 365046004808 PAS fold; Region: PAS_4; pfam08448 365046004809 putative active site [active] 365046004810 heme pocket [chemical binding]; other site 365046004811 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 365046004812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046004813 Walker A motif; other site 365046004814 ATP binding site [chemical binding]; other site 365046004815 Walker B motif; other site 365046004816 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 365046004817 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 365046004818 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 365046004819 putative ligand binding site [chemical binding]; other site 365046004820 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 365046004821 Interdomain contacts; other site 365046004822 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046004823 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046004824 Walker A/P-loop; other site 365046004825 ATP binding site [chemical binding]; other site 365046004826 Q-loop/lid; other site 365046004827 ABC transporter signature motif; other site 365046004828 Walker B; other site 365046004829 D-loop; other site 365046004830 H-loop/switch region; other site 365046004831 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046004832 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046004833 Walker A/P-loop; other site 365046004834 ATP binding site [chemical binding]; other site 365046004835 Q-loop/lid; other site 365046004836 ABC transporter signature motif; other site 365046004837 Walker B; other site 365046004838 D-loop; other site 365046004839 H-loop/switch region; other site 365046004840 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046004841 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046004842 TM-ABC transporter signature motif; other site 365046004843 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 365046004844 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046004845 TM-ABC transporter signature motif; other site 365046004846 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 365046004847 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046004848 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046004849 ferrochelatase; Reviewed; Region: hemH; PRK00035 365046004850 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 365046004851 C-terminal domain interface [polypeptide binding]; other site 365046004852 active site 365046004853 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 365046004854 active site 365046004855 N-terminal domain interface [polypeptide binding]; other site 365046004856 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 365046004857 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 365046004858 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 365046004859 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 365046004860 catalytic residues [active] 365046004861 substrate binding pocket [chemical binding]; other site 365046004862 substrate-Mg2+ binding site; other site 365046004863 aspartate-rich region 1; other site 365046004864 aspartate-rich region 2; other site 365046004865 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 365046004866 active site lid residues [active] 365046004867 substrate binding pocket [chemical binding]; other site 365046004868 catalytic residues [active] 365046004869 substrate-Mg2+ binding site; other site 365046004870 aspartate-rich region 1; other site 365046004871 aspartate-rich region 2; other site 365046004872 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 365046004873 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046004874 putative membrane fusion protein; Region: TIGR02828 365046004875 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 365046004876 trigger factor; Provisional; Region: tig; PRK01490 365046004877 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 365046004878 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 365046004879 Clp protease; Region: CLP_protease; pfam00574 365046004880 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 365046004881 oligomer interface [polypeptide binding]; other site 365046004882 active site residues [active] 365046004883 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 365046004884 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 365046004885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046004886 Walker A motif; other site 365046004887 ATP binding site [chemical binding]; other site 365046004888 Walker B motif; other site 365046004889 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 365046004890 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 365046004891 Found in ATP-dependent protease La (LON); Region: LON; smart00464 365046004892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046004893 Walker A motif; other site 365046004894 ATP binding site [chemical binding]; other site 365046004895 Walker B motif; other site 365046004896 arginine finger; other site 365046004897 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 365046004898 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 365046004899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046004900 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 365046004901 Fumarase C-terminus; Region: Fumerase_C; pfam05683 365046004902 fumarate hydratase; Reviewed; Region: fumC; PRK00485 365046004903 Class II fumarases; Region: Fumarase_classII; cd01362 365046004904 active site 365046004905 tetramer interface [polypeptide binding]; other site 365046004906 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 365046004907 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 365046004908 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 365046004909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046004910 dimer interface [polypeptide binding]; other site 365046004911 conserved gate region; other site 365046004912 ABC-ATPase subunit interface; other site 365046004913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046004914 dimer interface [polypeptide binding]; other site 365046004915 conserved gate region; other site 365046004916 putative PBP binding loops; other site 365046004917 ABC-ATPase subunit interface; other site 365046004918 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 365046004919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046004920 Walker A/P-loop; other site 365046004921 ATP binding site [chemical binding]; other site 365046004922 Q-loop/lid; other site 365046004923 ABC transporter signature motif; other site 365046004924 Walker B; other site 365046004925 D-loop; other site 365046004926 H-loop/switch region; other site 365046004927 TOBE domain; Region: TOBE_2; pfam08402 365046004928 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 365046004929 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 365046004930 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 365046004931 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 365046004932 tartrate dehydrogenase; Region: TTC; TIGR02089 365046004933 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 365046004934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046004935 DNA-binding site [nucleotide binding]; DNA binding site 365046004936 FCD domain; Region: FCD; pfam07729 365046004937 hypothetical protein; Provisional; Region: PRK05208 365046004938 acetyl-CoA synthetase; Provisional; Region: PRK00174 365046004939 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 365046004940 active site 365046004941 CoA binding site [chemical binding]; other site 365046004942 acyl-activating enzyme (AAE) consensus motif; other site 365046004943 AMP binding site [chemical binding]; other site 365046004944 acetate binding site [chemical binding]; other site 365046004945 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 365046004946 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 365046004947 active site 365046004948 nucleotide binding site [chemical binding]; other site 365046004949 HIGH motif; other site 365046004950 KMSKS motif; other site 365046004951 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 365046004952 nudix motif; other site 365046004953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046004954 S-adenosylmethionine binding site [chemical binding]; other site 365046004955 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 365046004956 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 365046004957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 365046004958 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 365046004959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 365046004960 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 365046004961 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 365046004962 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046004963 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 365046004964 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 365046004965 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 365046004966 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 365046004967 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 365046004968 putative NAD(P) binding site [chemical binding]; other site 365046004969 catalytic Zn binding site [ion binding]; other site 365046004970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046004971 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 365046004972 NAD(P) binding site [chemical binding]; other site 365046004973 active site 365046004974 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 365046004975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046004976 NAD(P) binding site [chemical binding]; other site 365046004977 active site 365046004978 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 365046004979 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 365046004980 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 365046004981 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046004982 catalytic core [active] 365046004983 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 365046004984 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 365046004985 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 365046004986 NAD binding site [chemical binding]; other site 365046004987 putative substrate binding site 2 [chemical binding]; other site 365046004988 putative substrate binding site 1 [chemical binding]; other site 365046004989 active site 365046004990 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 365046004991 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 365046004992 active site 365046004993 DNA binding site [nucleotide binding] 365046004994 Int/Topo IB signature motif; other site 365046004995 catalytic residues [active] 365046004996 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 365046004997 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 365046004998 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 365046004999 Cytochrome c; Region: Cytochrom_C; cl11414 365046005000 FAD dependent oxidoreductase; Region: DAO; pfam01266 365046005001 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 365046005002 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 365046005003 [2Fe-2S] cluster binding site [ion binding]; other site 365046005004 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 365046005005 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 365046005006 Transcriptional regulators [Transcription]; Region: GntR; COG1802 365046005007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046005008 DNA-binding site [nucleotide binding]; DNA binding site 365046005009 FCD domain; Region: FCD; pfam07729 365046005010 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 365046005011 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005012 malonyl-CoA synthase; Validated; Region: PRK07514 365046005013 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 365046005014 acyl-activating enzyme (AAE) consensus motif; other site 365046005015 active site 365046005016 AMP binding site [chemical binding]; other site 365046005017 CoA binding site [chemical binding]; other site 365046005018 BON domain; Region: BON; pfam04972 365046005019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046005020 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 365046005021 Coenzyme A binding pocket [chemical binding]; other site 365046005022 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 365046005023 FAD binding domain; Region: FAD_binding_4; pfam01565 365046005024 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 365046005025 Cysteine-rich domain; Region: CCG; pfam02754 365046005026 Transcriptional regulators [Transcription]; Region: GntR; COG1802 365046005027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046005028 DNA-binding site [nucleotide binding]; DNA binding site 365046005029 FCD domain; Region: FCD; pfam07729 365046005030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046005031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046005032 catalytic residue [active] 365046005033 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005034 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046005035 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046005036 enoyl-CoA hydratase; Provisional; Region: PRK06144 365046005037 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046005038 substrate binding site [chemical binding]; other site 365046005039 oxyanion hole (OAH) forming residues; other site 365046005040 trimer interface [polypeptide binding]; other site 365046005041 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 365046005042 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 365046005043 TRAP binding interface [polypeptide binding]; other site 365046005044 Zn binding site [ion binding]; other site 365046005045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046005046 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 365046005047 Cell division protein ZapA; Region: ZapA; pfam05164 365046005048 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 365046005049 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 365046005050 N-terminal plug; other site 365046005051 ligand-binding site [chemical binding]; other site 365046005052 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 365046005053 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 365046005054 intersubunit interface [polypeptide binding]; other site 365046005055 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 365046005056 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 365046005057 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 365046005058 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 365046005059 catalytic triad [active] 365046005060 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 365046005061 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 365046005062 intersubunit interface [polypeptide binding]; other site 365046005063 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 365046005064 putative PBP binding regions; other site 365046005065 ABC-ATPase subunit interface; other site 365046005066 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 365046005067 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 365046005068 Walker A/P-loop; other site 365046005069 ATP binding site [chemical binding]; other site 365046005070 Q-loop/lid; other site 365046005071 ABC transporter signature motif; other site 365046005072 Walker B; other site 365046005073 D-loop; other site 365046005074 H-loop/switch region; other site 365046005075 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 365046005076 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 365046005077 homodimer interface [polypeptide binding]; other site 365046005078 Walker A motif; other site 365046005079 ATP binding site [chemical binding]; other site 365046005080 hydroxycobalamin binding site [chemical binding]; other site 365046005081 Walker B motif; other site 365046005082 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 365046005083 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 365046005084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046005085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046005086 catalytic residue [active] 365046005087 cobyric acid synthase; Provisional; Region: PRK00784 365046005088 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 365046005089 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 365046005090 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 365046005091 catalytic triad [active] 365046005092 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 365046005093 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 365046005094 putative dimer interface [polypeptide binding]; other site 365046005095 active site pocket [active] 365046005096 putative cataytic base [active] 365046005097 cobalamin synthase; Reviewed; Region: cobS; PRK00235 365046005098 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046005099 catalytic core [active] 365046005100 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 365046005101 Ligand Binding Site [chemical binding]; other site 365046005102 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 365046005103 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 365046005104 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046005105 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 365046005106 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 365046005107 Protein export membrane protein; Region: SecD_SecF; cl14618 365046005108 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 365046005109 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 365046005110 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 365046005111 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 365046005112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046005113 dimerization interface [polypeptide binding]; other site 365046005114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046005115 PAS fold; Region: PAS_3; pfam08447 365046005116 putative active site [active] 365046005117 heme pocket [chemical binding]; other site 365046005118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046005119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046005120 dimer interface [polypeptide binding]; other site 365046005121 phosphorylation site [posttranslational modification] 365046005122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046005123 ATP binding site [chemical binding]; other site 365046005124 Mg2+ binding site [ion binding]; other site 365046005125 G-X-G motif; other site 365046005126 Response regulator receiver domain; Region: Response_reg; pfam00072 365046005127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046005128 active site 365046005129 phosphorylation site [posttranslational modification] 365046005130 intermolecular recognition site; other site 365046005131 dimerization interface [polypeptide binding]; other site 365046005132 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 365046005133 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 365046005134 HSP70 interaction site [polypeptide binding]; other site 365046005135 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 365046005136 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 365046005137 minor groove reading motif; other site 365046005138 helix-hairpin-helix signature motif; other site 365046005139 substrate binding pocket [chemical binding]; other site 365046005140 active site 365046005141 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 365046005142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046005143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046005144 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 365046005145 putative dimerization interface [polypeptide binding]; other site 365046005146 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005147 Uncharacterized conserved protein [Function unknown]; Region: COG3777 365046005148 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 365046005149 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 365046005150 active site 2 [active] 365046005151 active site 1 [active] 365046005152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046005153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046005154 active site 365046005155 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046005156 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046005157 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 365046005158 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005159 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005160 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 365046005161 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 365046005162 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005163 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 365046005164 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 365046005165 PYR/PP interface [polypeptide binding]; other site 365046005166 dimer interface [polypeptide binding]; other site 365046005167 TPP binding site [chemical binding]; other site 365046005168 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 365046005169 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 365046005170 TPP-binding site [chemical binding]; other site 365046005171 dimer interface [polypeptide binding]; other site 365046005172 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 365046005173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046005174 catalytic loop [active] 365046005175 iron binding site [ion binding]; other site 365046005176 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 365046005177 FAD binding pocket [chemical binding]; other site 365046005178 FAD binding motif [chemical binding]; other site 365046005179 phosphate binding motif [ion binding]; other site 365046005180 beta-alpha-beta structure motif; other site 365046005181 NAD binding pocket [chemical binding]; other site 365046005182 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 365046005183 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 365046005184 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 365046005185 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 365046005186 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 365046005187 iron-sulfur cluster [ion binding]; other site 365046005188 [2Fe-2S] cluster binding site [ion binding]; other site 365046005189 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 365046005190 putative alpha subunit interface [polypeptide binding]; other site 365046005191 putative active site [active] 365046005192 putative substrate binding site [chemical binding]; other site 365046005193 Fe binding site [ion binding]; other site 365046005194 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005195 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 365046005196 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 365046005197 Bacterial transcriptional regulator; Region: IclR; pfam01614 365046005198 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 365046005199 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 365046005200 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 365046005201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046005202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046005203 homodimer interface [polypeptide binding]; other site 365046005204 catalytic residue [active] 365046005205 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 365046005206 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 365046005207 Hemerythrin family; Region: Hemerythrin-like; cl15774 365046005208 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 365046005209 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 365046005210 active site 365046005211 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 365046005212 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 365046005213 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 365046005214 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 365046005215 ligand binding site [chemical binding]; other site 365046005216 NAD binding site [chemical binding]; other site 365046005217 tetramer interface [polypeptide binding]; other site 365046005218 catalytic site [active] 365046005219 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 365046005220 L-serine binding site [chemical binding]; other site 365046005221 ACT domain interface; other site 365046005222 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 365046005223 putative hydrophobic ligand binding site [chemical binding]; other site 365046005224 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 365046005225 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005226 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 365046005227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 365046005228 active site 365046005229 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 365046005230 LabA_like proteins; Region: LabA_like; cd06167 365046005231 putative metal binding site [ion binding]; other site 365046005232 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 365046005233 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 365046005234 putative active site [active] 365046005235 catalytic site [active] 365046005236 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 365046005237 putative active site [active] 365046005238 catalytic site [active] 365046005239 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 365046005240 putative active site [active] 365046005241 metal binding site [ion binding]; metal-binding site 365046005242 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 365046005243 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 365046005244 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 365046005245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046005246 S-adenosylmethionine binding site [chemical binding]; other site 365046005247 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 365046005248 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 365046005249 catalytic core [active] 365046005250 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 365046005251 Asp-box motif; other site 365046005252 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 365046005253 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 365046005254 C-terminal domain interface [polypeptide binding]; other site 365046005255 GSH binding site (G-site) [chemical binding]; other site 365046005256 dimer interface [polypeptide binding]; other site 365046005257 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 365046005258 N-terminal domain interface [polypeptide binding]; other site 365046005259 dimer interface [polypeptide binding]; other site 365046005260 substrate binding pocket (H-site) [chemical binding]; other site 365046005261 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 365046005262 thioredoxin 2; Provisional; Region: PRK10996 365046005263 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 365046005264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 365046005265 catalytic residues [active] 365046005266 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 365046005267 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 365046005268 Transglycosylase; Region: Transgly; pfam00912 365046005269 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 365046005270 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 365046005271 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 365046005272 PilZ domain; Region: PilZ; pfam07238 365046005273 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 365046005274 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 365046005275 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 365046005276 putative ligand binding site [chemical binding]; other site 365046005277 PhoD-like phosphatase; Region: PhoD; pfam09423 365046005278 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 365046005279 putative active site [active] 365046005280 putative metal binding site [ion binding]; other site 365046005281 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 365046005282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046005283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046005284 NAD(P) binding site [chemical binding]; other site 365046005285 active site 365046005286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 365046005287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046005288 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 365046005289 phosphoserine phosphatase SerB; Region: serB; TIGR00338 365046005290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046005291 motif II; other site 365046005292 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 365046005293 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 365046005294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046005295 ATP binding site [chemical binding]; other site 365046005296 putative Mg++ binding site [ion binding]; other site 365046005297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046005298 nucleotide binding region [chemical binding]; other site 365046005299 ATP-binding site [chemical binding]; other site 365046005300 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 365046005301 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 365046005302 substrate binding site; other site 365046005303 dimer interface; other site 365046005304 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 365046005305 homotrimer interaction site [polypeptide binding]; other site 365046005306 zinc binding site [ion binding]; other site 365046005307 CDP-binding sites; other site 365046005308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046005309 dimerization interface [polypeptide binding]; other site 365046005310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046005311 dimer interface [polypeptide binding]; other site 365046005312 phosphorylation site [posttranslational modification] 365046005313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046005314 ATP binding site [chemical binding]; other site 365046005315 Mg2+ binding site [ion binding]; other site 365046005316 G-X-G motif; other site 365046005317 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 365046005318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046005319 active site 365046005320 phosphorylation site [posttranslational modification] 365046005321 intermolecular recognition site; other site 365046005322 dimerization interface [polypeptide binding]; other site 365046005323 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046005324 DNA binding site [nucleotide binding] 365046005325 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 365046005326 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 365046005327 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 365046005328 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 365046005329 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 365046005330 active site 365046005331 metal binding site [ion binding]; metal-binding site 365046005332 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 365046005333 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 365046005334 NAD binding site [chemical binding]; other site 365046005335 homotetramer interface [polypeptide binding]; other site 365046005336 homodimer interface [polypeptide binding]; other site 365046005337 substrate binding site [chemical binding]; other site 365046005338 active site 365046005339 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 365046005340 HD domain; Region: HD_4; pfam13328 365046005341 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 365046005342 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 365046005343 synthetase active site [active] 365046005344 NTP binding site [chemical binding]; other site 365046005345 metal binding site [ion binding]; metal-binding site 365046005346 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 365046005347 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 365046005348 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 365046005349 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 365046005350 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 365046005351 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 365046005352 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 365046005353 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 365046005354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 365046005355 FeS/SAM binding site; other site 365046005356 ribonuclease R; Region: RNase_R; TIGR02063 365046005357 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 365046005358 RNB domain; Region: RNB; pfam00773 365046005359 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 365046005360 RNA binding site [nucleotide binding]; other site 365046005361 classical (c) SDRs; Region: SDR_c; cd05233 365046005362 NAD(P) binding site [chemical binding]; other site 365046005363 active site 365046005364 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 365046005365 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 365046005366 putative substrate binding site [chemical binding]; other site 365046005367 putative ATP binding site [chemical binding]; other site 365046005368 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 365046005369 hydroxyglutarate oxidase; Provisional; Region: PRK11728 365046005370 amidase; Provisional; Region: PRK07056 365046005371 Amidase; Region: Amidase; cl11426 365046005372 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 365046005373 rRNA interaction site [nucleotide binding]; other site 365046005374 S8 interaction site; other site 365046005375 putative laminin-1 binding site; other site 365046005376 elongation factor Ts; Provisional; Region: tsf; PRK09377 365046005377 UBA/TS-N domain; Region: UBA; pfam00627 365046005378 Elongation factor TS; Region: EF_TS; pfam00889 365046005379 Elongation factor TS; Region: EF_TS; pfam00889 365046005380 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 365046005381 putative nucleotide binding site [chemical binding]; other site 365046005382 uridine monophosphate binding site [chemical binding]; other site 365046005383 homohexameric interface [polypeptide binding]; other site 365046005384 ribosome recycling factor; Reviewed; Region: frr; PRK00083 365046005385 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 365046005386 hinge region; other site 365046005387 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 365046005388 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 365046005389 catalytic residue [active] 365046005390 putative FPP diphosphate binding site; other site 365046005391 putative FPP binding hydrophobic cleft; other site 365046005392 dimer interface [polypeptide binding]; other site 365046005393 putative IPP diphosphate binding site; other site 365046005394 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 365046005395 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 365046005396 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 365046005397 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 365046005398 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 365046005399 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 365046005400 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 365046005401 zinc metallopeptidase RseP; Provisional; Region: PRK10779 365046005402 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 365046005403 active site 365046005404 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 365046005405 protein binding site [polypeptide binding]; other site 365046005406 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 365046005407 putative substrate binding region [chemical binding]; other site 365046005408 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 365046005409 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 365046005410 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 365046005411 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 365046005412 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 365046005413 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 365046005414 Surface antigen; Region: Bac_surface_Ag; pfam01103 365046005415 periplasmic chaperone; Provisional; Region: PRK10780 365046005416 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 365046005417 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 365046005418 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 365046005419 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 365046005420 trimer interface [polypeptide binding]; other site 365046005421 active site 365046005422 UDP-GlcNAc binding site [chemical binding]; other site 365046005423 lipid binding site [chemical binding]; lipid-binding site 365046005424 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 365046005425 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 365046005426 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 365046005427 active site 365046005428 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 365046005429 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 365046005430 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 365046005431 RNA/DNA hybrid binding site [nucleotide binding]; other site 365046005432 active site 365046005433 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 365046005434 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 365046005435 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 365046005436 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 365046005437 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 365046005438 catalytic site [active] 365046005439 subunit interface [polypeptide binding]; other site 365046005440 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 365046005441 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 365046005442 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 365046005443 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 365046005444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 365046005445 ATP-grasp domain; Region: ATP-grasp_4; cl17255 365046005446 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 365046005447 IMP binding site; other site 365046005448 dimer interface [polypeptide binding]; other site 365046005449 interdomain contacts; other site 365046005450 partial ornithine binding site; other site 365046005451 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 365046005452 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 365046005453 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 365046005454 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 365046005455 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 365046005456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046005457 S-adenosylmethionine binding site [chemical binding]; other site 365046005458 FtsH Extracellular; Region: FtsH_ext; pfam06480 365046005459 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 365046005460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046005461 Walker A motif; other site 365046005462 ATP binding site [chemical binding]; other site 365046005463 Walker B motif; other site 365046005464 arginine finger; other site 365046005465 Peptidase family M41; Region: Peptidase_M41; pfam01434 365046005466 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 365046005467 classical (c) SDRs; Region: SDR_c; cd05233 365046005468 NAD(P) binding site [chemical binding]; other site 365046005469 active site 365046005470 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046005471 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 365046005472 TM-ABC transporter signature motif; other site 365046005473 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 365046005474 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046005475 TM-ABC transporter signature motif; other site 365046005476 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 365046005477 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 365046005478 Walker A/P-loop; other site 365046005479 ATP binding site [chemical binding]; other site 365046005480 Q-loop/lid; other site 365046005481 ABC transporter signature motif; other site 365046005482 Walker B; other site 365046005483 D-loop; other site 365046005484 H-loop/switch region; other site 365046005485 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 365046005486 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 365046005487 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 365046005488 putative ligand binding site [chemical binding]; other site 365046005489 Transcriptional regulators [Transcription]; Region: PurR; COG1609 365046005490 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 365046005491 DNA binding site [nucleotide binding] 365046005492 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 365046005493 putative dimerization interface [polypeptide binding]; other site 365046005494 putative ligand binding site [chemical binding]; other site 365046005495 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 365046005496 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 365046005497 active site 365046005498 catalytic residues [active] 365046005499 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 365046005500 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 365046005501 dihydropteroate synthase; Region: DHPS; TIGR01496 365046005502 substrate binding pocket [chemical binding]; other site 365046005503 dimer interface [polypeptide binding]; other site 365046005504 inhibitor binding site; inhibition site 365046005505 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 365046005506 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 365046005507 active site 365046005508 substrate binding site [chemical binding]; other site 365046005509 metal binding site [ion binding]; metal-binding site 365046005510 MOSC domain; Region: MOSC; pfam03473 365046005511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 365046005512 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 365046005513 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 365046005514 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 365046005515 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 365046005516 active site 365046005517 dimer interface [polypeptide binding]; other site 365046005518 motif 1; other site 365046005519 motif 2; other site 365046005520 motif 3; other site 365046005521 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 365046005522 anticodon binding site; other site 365046005523 translation initiation factor IF-3; Region: infC; TIGR00168 365046005524 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 365046005525 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 365046005526 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 365046005527 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 365046005528 23S rRNA binding site [nucleotide binding]; other site 365046005529 L21 binding site [polypeptide binding]; other site 365046005530 L13 binding site [polypeptide binding]; other site 365046005531 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 365046005532 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 365046005533 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 365046005534 dimer interface [polypeptide binding]; other site 365046005535 motif 1; other site 365046005536 active site 365046005537 motif 2; other site 365046005538 motif 3; other site 365046005539 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 365046005540 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 365046005541 putative tRNA-binding site [nucleotide binding]; other site 365046005542 B3/4 domain; Region: B3_4; pfam03483 365046005543 tRNA synthetase B5 domain; Region: B5; smart00874 365046005544 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 365046005545 dimer interface [polypeptide binding]; other site 365046005546 motif 1; other site 365046005547 motif 3; other site 365046005548 motif 2; other site 365046005549 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 365046005550 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 365046005551 IHF - DNA interface [nucleotide binding]; other site 365046005552 IHF dimer interface [polypeptide binding]; other site 365046005553 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 365046005554 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 365046005555 DNA binding residues [nucleotide binding] 365046005556 cyclase homology domain; Region: CHD; cd07302 365046005557 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 365046005558 nucleotidyl binding site; other site 365046005559 metal binding site [ion binding]; metal-binding site 365046005560 dimer interface [polypeptide binding]; other site 365046005561 FHA domain; Region: FHA; pfam00498 365046005562 phosphopeptide binding site; other site 365046005563 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 365046005564 phosphopeptide binding site; other site 365046005565 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 365046005566 Catalytic domain of Protein Kinases; Region: PKc; cd00180 365046005567 active site 365046005568 ATP binding site [chemical binding]; other site 365046005569 substrate binding site [chemical binding]; other site 365046005570 activation loop (A-loop); other site 365046005571 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 365046005572 nudix motif; other site 365046005573 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046005574 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046005575 DctM-like transporters; Region: DctM; pfam06808 365046005576 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 365046005577 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 365046005578 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 365046005579 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 365046005580 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 365046005581 Cupin domain; Region: Cupin_2; pfam07883 365046005582 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 365046005583 salicylate hydroxylase; Provisional; Region: PRK08163 365046005584 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 365046005585 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 365046005586 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 365046005587 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 365046005588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 365046005589 ligand binding site [chemical binding]; other site 365046005590 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 365046005591 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 365046005592 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 365046005593 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 365046005594 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 365046005595 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 365046005596 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 365046005597 alpha subunit interface [polypeptide binding]; other site 365046005598 active site 365046005599 substrate binding site [chemical binding]; other site 365046005600 Fe binding site [ion binding]; other site 365046005601 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 365046005602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046005603 DNA-binding site [nucleotide binding]; DNA binding site 365046005604 FCD domain; Region: FCD; pfam07729 365046005605 AzlC protein; Region: AzlC; cl00570 365046005606 Predicted membrane protein [Function unknown]; Region: COG4541 365046005607 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 365046005608 Uncharacterized conserved protein [Function unknown]; Region: COG3791 365046005609 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 365046005610 maleylacetoacetate isomerase; Region: maiA; TIGR01262 365046005611 C-terminal domain interface [polypeptide binding]; other site 365046005612 GSH binding site (G-site) [chemical binding]; other site 365046005613 putative dimer interface [polypeptide binding]; other site 365046005614 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 365046005615 dimer interface [polypeptide binding]; other site 365046005616 N-terminal domain interface [polypeptide binding]; other site 365046005617 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 365046005618 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 365046005619 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 365046005620 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 365046005621 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 365046005622 putative acyltransferase; Provisional; Region: PRK05790 365046005623 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 365046005624 dimer interface [polypeptide binding]; other site 365046005625 active site 365046005626 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 365046005627 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 365046005628 NAD(P) binding site [chemical binding]; other site 365046005629 homotetramer interface [polypeptide binding]; other site 365046005630 homodimer interface [polypeptide binding]; other site 365046005631 active site 365046005632 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 365046005633 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 365046005634 FMN binding site [chemical binding]; other site 365046005635 active site 365046005636 catalytic residues [active] 365046005637 substrate binding site [chemical binding]; other site 365046005638 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 365046005639 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 365046005640 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 365046005641 active site 365046005642 FMN binding site [chemical binding]; other site 365046005643 substrate binding site [chemical binding]; other site 365046005644 homotetramer interface [polypeptide binding]; other site 365046005645 catalytic residue [active] 365046005646 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 365046005647 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046005648 substrate binding site [chemical binding]; other site 365046005649 oxyanion hole (OAH) forming residues; other site 365046005650 trimer interface [polypeptide binding]; other site 365046005651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046005652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046005653 active site 365046005654 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 365046005655 homotrimer interaction site [polypeptide binding]; other site 365046005656 putative active site [active] 365046005657 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 365046005658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046005659 FAD binding site [chemical binding]; other site 365046005660 substrate binding pocket [chemical binding]; other site 365046005661 catalytic base [active] 365046005662 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005663 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 365046005664 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 365046005665 putative active site [active] 365046005666 Transcriptional regulators [Transcription]; Region: FadR; COG2186 365046005667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046005668 DNA-binding site [nucleotide binding]; DNA binding site 365046005669 FCD domain; Region: FCD; pfam07729 365046005670 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 365046005671 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 365046005672 active site 365046005673 substrate binding site [chemical binding]; other site 365046005674 coenzyme B12 binding site [chemical binding]; other site 365046005675 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 365046005676 B12 binding site [chemical binding]; other site 365046005677 cobalt ligand [ion binding]; other site 365046005678 membrane ATPase/protein kinase; Provisional; Region: PRK09435 365046005679 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 365046005680 Walker A; other site 365046005681 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 365046005682 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 365046005683 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 365046005684 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 365046005685 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 365046005686 Uncharacterized conserved protein [Function unknown]; Region: COG1434 365046005687 putative active site [active] 365046005688 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 365046005689 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 365046005690 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 365046005691 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 365046005692 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 365046005693 carboxyltransferase (CT) interaction site; other site 365046005694 biotinylation site [posttranslational modification]; other site 365046005695 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 365046005696 dimer interface [polypeptide binding]; other site 365046005697 substrate binding site [chemical binding]; other site 365046005698 metal binding site [ion binding]; metal-binding site 365046005699 D-cysteine desulfhydrase; Validated; Region: PRK03910 365046005700 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 365046005701 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046005702 catalytic residue [active] 365046005703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046005704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046005705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 365046005706 dimerization interface [polypeptide binding]; other site 365046005707 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 365046005708 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 365046005709 ferredoxin; Provisional; Region: PRK08764 365046005710 Putative Fe-S cluster; Region: FeS; pfam04060 365046005711 4Fe-4S binding domain; Region: Fer4; pfam00037 365046005712 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 365046005713 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 365046005714 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 365046005715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046005716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046005717 homodimer interface [polypeptide binding]; other site 365046005718 catalytic residue [active] 365046005719 excinuclease ABC subunit B; Provisional; Region: PRK05298 365046005720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046005721 ATP binding site [chemical binding]; other site 365046005722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046005723 nucleotide binding region [chemical binding]; other site 365046005724 ATP-binding site [chemical binding]; other site 365046005725 Ultra-violet resistance protein B; Region: UvrB; pfam12344 365046005726 UvrB/uvrC motif; Region: UVR; pfam02151 365046005727 Predicted transcriptional regulator [Transcription]; Region: COG1959 365046005728 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 365046005729 cysteine desulfurase; Provisional; Region: PRK14012 365046005730 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 365046005731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046005732 catalytic residue [active] 365046005733 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 365046005734 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 365046005735 trimerization site [polypeptide binding]; other site 365046005736 active site 365046005737 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 365046005738 co-chaperone HscB; Provisional; Region: hscB; PRK03578 365046005739 DnaJ domain; Region: DnaJ; pfam00226 365046005740 chaperone protein HscA; Provisional; Region: hscA; PRK05183 365046005741 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 365046005742 nucleotide binding site [chemical binding]; other site 365046005743 putative NEF/HSP70 interaction site [polypeptide binding]; other site 365046005744 SBD interface [polypeptide binding]; other site 365046005745 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 365046005746 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046005747 catalytic loop [active] 365046005748 iron binding site [ion binding]; other site 365046005749 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 365046005750 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 365046005751 tetramer interface [polypeptide binding]; other site 365046005752 active site 365046005753 Mg2+/Mn2+ binding site [ion binding]; other site 365046005754 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 365046005755 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 365046005756 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 365046005757 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046005758 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046005759 active site 365046005760 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 365046005761 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 365046005762 substrate binding site [chemical binding]; other site 365046005763 3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065 365046005764 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 365046005765 substrate binding site [chemical binding]; other site 365046005766 ligand binding site [chemical binding]; other site 365046005767 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046005768 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 365046005769 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046005770 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046005771 Walker A/P-loop; other site 365046005772 ATP binding site [chemical binding]; other site 365046005773 Q-loop/lid; other site 365046005774 ABC transporter signature motif; other site 365046005775 Walker B; other site 365046005776 D-loop; other site 365046005777 H-loop/switch region; other site 365046005778 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046005779 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046005780 Walker A/P-loop; other site 365046005781 ATP binding site [chemical binding]; other site 365046005782 Q-loop/lid; other site 365046005783 ABC transporter signature motif; other site 365046005784 Walker B; other site 365046005785 D-loop; other site 365046005786 H-loop/switch region; other site 365046005787 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 365046005788 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046005789 TM-ABC transporter signature motif; other site 365046005790 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046005791 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046005792 TM-ABC transporter signature motif; other site 365046005793 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 365046005794 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 365046005795 putative ligand binding site [chemical binding]; other site 365046005796 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 365046005797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046005798 DNA-binding site [nucleotide binding]; DNA binding site 365046005799 UTRA domain; Region: UTRA; pfam07702 365046005800 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 365046005801 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 365046005802 active site 365046005803 catalytic site [active] 365046005804 substrate binding site [chemical binding]; other site 365046005805 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 365046005806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046005807 NAD(P) binding site [chemical binding]; other site 365046005808 active site 365046005809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046005810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046005811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046005812 dimerization interface [polypeptide binding]; other site 365046005813 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 365046005814 Predicted dehydrogenase [General function prediction only]; Region: COG0579 365046005815 hydroxyglutarate oxidase; Provisional; Region: PRK11728 365046005816 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 365046005817 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 365046005818 quinone interaction residues [chemical binding]; other site 365046005819 active site 365046005820 catalytic residues [active] 365046005821 FMN binding site [chemical binding]; other site 365046005822 substrate binding site [chemical binding]; other site 365046005823 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 365046005824 tetramer (dimer of dimers) interface [polypeptide binding]; other site 365046005825 active site 365046005826 dimer interface [polypeptide binding]; other site 365046005827 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 365046005828 catalytic residues [active] 365046005829 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 365046005830 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 365046005831 active site 365046005832 Zn binding site [ion binding]; other site 365046005833 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 365046005834 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 365046005835 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 365046005836 homodimer interface [polypeptide binding]; other site 365046005837 NADP binding site [chemical binding]; other site 365046005838 substrate binding site [chemical binding]; other site 365046005839 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 365046005840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046005841 active site 365046005842 phosphorylation site [posttranslational modification] 365046005843 intermolecular recognition site; other site 365046005844 dimerization interface [polypeptide binding]; other site 365046005845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046005846 DNA binding residues [nucleotide binding] 365046005847 dimerization interface [polypeptide binding]; other site 365046005848 PAS domain S-box; Region: sensory_box; TIGR00229 365046005849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046005850 putative active site [active] 365046005851 heme pocket [chemical binding]; other site 365046005852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046005853 dimer interface [polypeptide binding]; other site 365046005854 phosphorylation site [posttranslational modification] 365046005855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046005856 ATP binding site [chemical binding]; other site 365046005857 Mg2+ binding site [ion binding]; other site 365046005858 G-X-G motif; other site 365046005859 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 365046005860 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 365046005861 dimer interface [polypeptide binding]; other site 365046005862 TPP-binding site [chemical binding]; other site 365046005863 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 365046005864 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 365046005865 E3 interaction surface; other site 365046005866 lipoyl attachment site [posttranslational modification]; other site 365046005867 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 365046005868 E3 interaction surface; other site 365046005869 lipoyl attachment site [posttranslational modification]; other site 365046005870 e3 binding domain; Region: E3_binding; pfam02817 365046005871 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 365046005872 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 365046005873 active site 365046005874 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 365046005875 E3 interaction surface; other site 365046005876 lipoyl attachment site [posttranslational modification]; other site 365046005877 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 365046005878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 365046005879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046005880 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 365046005881 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 365046005882 NlpC/P60 family; Region: NLPC_P60; pfam00877 365046005883 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 365046005884 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 365046005885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046005886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046005887 active site 365046005888 phosphorylation site [posttranslational modification] 365046005889 intermolecular recognition site; other site 365046005890 dimerization interface [polypeptide binding]; other site 365046005891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046005892 DNA binding residues [nucleotide binding] 365046005893 dimerization interface [polypeptide binding]; other site 365046005894 Response regulator receiver domain; Region: Response_reg; pfam00072 365046005895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046005896 active site 365046005897 phosphorylation site [posttranslational modification] 365046005898 intermolecular recognition site; other site 365046005899 dimerization interface [polypeptide binding]; other site 365046005900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 365046005901 Histidine kinase; Region: HisKA_3; pfam07730 365046005902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046005903 ATP binding site [chemical binding]; other site 365046005904 Mg2+ binding site [ion binding]; other site 365046005905 G-X-G motif; other site 365046005906 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 365046005907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 365046005908 metal binding site [ion binding]; metal-binding site 365046005909 active site 365046005910 I-site; other site 365046005911 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 365046005912 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046005913 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 365046005914 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 365046005915 catalytic triad [active] 365046005916 dimer interface [polypeptide binding]; other site 365046005917 conserved cis-peptide bond; other site 365046005918 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 365046005919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046005920 acyl-activating enzyme (AAE) consensus motif; other site 365046005921 AMP binding site [chemical binding]; other site 365046005922 active site 365046005923 CoA binding site [chemical binding]; other site 365046005924 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 365046005925 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 365046005926 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 365046005927 TPP-binding site [chemical binding]; other site 365046005928 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 365046005929 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 365046005930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 365046005931 E3 interaction surface; other site 365046005932 lipoyl attachment site [posttranslational modification]; other site 365046005933 e3 binding domain; Region: E3_binding; pfam02817 365046005934 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 365046005935 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 365046005936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046005937 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 365046005938 Predicted ATPase [General function prediction only]; Region: COG1485 365046005939 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 365046005940 active site 365046005941 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 365046005942 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 365046005943 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 365046005944 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 365046005945 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 365046005946 RNA binding surface [nucleotide binding]; other site 365046005947 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 365046005948 active site 365046005949 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 365046005950 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 365046005951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 365046005952 RNA binding surface [nucleotide binding]; other site 365046005953 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 365046005954 probable active site [active] 365046005955 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 365046005956 active site 365046005957 multimer interface [polypeptide binding]; other site 365046005958 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 365046005959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 365046005960 FeS/SAM binding site; other site 365046005961 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 365046005962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 365046005963 binding surface 365046005964 TPR motif; other site 365046005965 Helix-turn-helix domain; Region: HTH_25; pfam13413 365046005966 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 365046005967 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 365046005968 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 365046005969 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 365046005970 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 365046005971 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 365046005972 dimer interface [polypeptide binding]; other site 365046005973 motif 1; other site 365046005974 active site 365046005975 motif 2; other site 365046005976 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 365046005977 anticodon binding site; other site 365046005978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 365046005979 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 365046005980 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 365046005981 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 365046005982 Trp docking motif [polypeptide binding]; other site 365046005983 active site 365046005984 GTP-binding protein Der; Reviewed; Region: PRK00093 365046005985 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 365046005986 G1 box; other site 365046005987 GTP/Mg2+ binding site [chemical binding]; other site 365046005988 Switch I region; other site 365046005989 G2 box; other site 365046005990 Switch II region; other site 365046005991 G3 box; other site 365046005992 G4 box; other site 365046005993 G5 box; other site 365046005994 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 365046005995 G1 box; other site 365046005996 GTP/Mg2+ binding site [chemical binding]; other site 365046005997 Switch I region; other site 365046005998 G2 box; other site 365046005999 G3 box; other site 365046006000 Switch II region; other site 365046006001 G4 box; other site 365046006002 G5 box; other site 365046006003 bacterial Hfq-like; Region: Hfq; cd01716 365046006004 hexamer interface [polypeptide binding]; other site 365046006005 Sm1 motif; other site 365046006006 RNA binding site [nucleotide binding]; other site 365046006007 Sm2 motif; other site 365046006008 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 365046006009 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 365046006010 HflX GTPase family; Region: HflX; cd01878 365046006011 G1 box; other site 365046006012 GTP/Mg2+ binding site [chemical binding]; other site 365046006013 Switch I region; other site 365046006014 G2 box; other site 365046006015 G3 box; other site 365046006016 Switch II region; other site 365046006017 G4 box; other site 365046006018 G5 box; other site 365046006019 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 365046006020 HflK protein; Region: hflK; TIGR01933 365046006021 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 365046006022 HflK protein; Region: hflK; TIGR01933 365046006023 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 365046006024 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 365046006025 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 365046006026 dimer interface [polypeptide binding]; other site 365046006027 motif 1; other site 365046006028 active site 365046006029 motif 2; other site 365046006030 motif 3; other site 365046006031 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 365046006032 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 365046006033 GDP-binding site [chemical binding]; other site 365046006034 ACT binding site; other site 365046006035 IMP binding site; other site 365046006036 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 365046006037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 365046006038 active site 365046006039 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 365046006040 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 365046006041 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046006042 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046006043 catalytic residue [active] 365046006044 Transcriptional regulators [Transcription]; Region: FadR; COG2186 365046006045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046006046 DNA-binding site [nucleotide binding]; DNA binding site 365046006047 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 365046006048 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 365046006049 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 365046006050 putative active site [active] 365046006051 catalytic residue [active] 365046006052 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046006053 galactarate dehydratase; Region: galactar-dH20; TIGR03248 365046006054 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 365046006055 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 365046006056 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 365046006057 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 365046006058 active site 365046006059 tetramer interface [polypeptide binding]; other site 365046006060 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 365046006061 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 365046006062 active site residue [active] 365046006063 AAA domain; Region: AAA_17; pfam13207 365046006064 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 365046006065 active site 365046006066 catalytic triad [active] 365046006067 oxyanion hole [active] 365046006068 switch loop; other site 365046006069 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 365046006070 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 365046006071 Walker A/P-loop; other site 365046006072 ATP binding site [chemical binding]; other site 365046006073 Q-loop/lid; other site 365046006074 ABC transporter signature motif; other site 365046006075 Walker B; other site 365046006076 D-loop; other site 365046006077 H-loop/switch region; other site 365046006078 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 365046006079 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 365046006080 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 365046006081 NAD-dependent deacetylase; Provisional; Region: PRK00481 365046006082 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 365046006083 NAD+ binding site [chemical binding]; other site 365046006084 substrate binding site [chemical binding]; other site 365046006085 Zn binding site [ion binding]; other site 365046006086 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 365046006087 Chromate transporter; Region: Chromate_transp; pfam02417 365046006088 Chromate transporter; Region: Chromate_transp; pfam02417 365046006089 Transcriptional regulators [Transcription]; Region: MarR; COG1846 365046006090 MarR family; Region: MarR; pfam01047 365046006091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046006092 Coenzyme A binding pocket [chemical binding]; other site 365046006093 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 365046006094 Moco binding site; other site 365046006095 metal coordination site [ion binding]; other site 365046006096 dimerization interface [polypeptide binding]; other site 365046006097 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 365046006098 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046006099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006100 active site 365046006101 phosphorylation site [posttranslational modification] 365046006102 intermolecular recognition site; other site 365046006103 dimerization interface [polypeptide binding]; other site 365046006104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046006105 DNA binding residues [nucleotide binding] 365046006106 dimerization interface [polypeptide binding]; other site 365046006107 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 365046006108 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046006109 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 365046006110 PAS domain S-box; Region: sensory_box; TIGR00229 365046006111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046006112 putative active site [active] 365046006113 heme pocket [chemical binding]; other site 365046006114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046006115 PAS domain; Region: PAS_9; pfam13426 365046006116 putative active site [active] 365046006117 heme pocket [chemical binding]; other site 365046006118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 365046006119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006120 ATP binding site [chemical binding]; other site 365046006121 Mg2+ binding site [ion binding]; other site 365046006122 G-X-G motif; other site 365046006123 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006125 active site 365046006126 phosphorylation site [posttranslational modification] 365046006127 intermolecular recognition site; other site 365046006128 dimerization interface [polypeptide binding]; other site 365046006129 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006131 active site 365046006132 phosphorylation site [posttranslational modification] 365046006133 intermolecular recognition site; other site 365046006134 dimerization interface [polypeptide binding]; other site 365046006135 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006137 active site 365046006138 phosphorylation site [posttranslational modification] 365046006139 intermolecular recognition site; other site 365046006140 dimerization interface [polypeptide binding]; other site 365046006141 CheW-like domain; Region: CheW; pfam01584 365046006142 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 365046006143 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 365046006144 dimer interface [polypeptide binding]; other site 365046006145 putative CheW interface [polypeptide binding]; other site 365046006146 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 365046006147 putative binding surface; other site 365046006148 active site 365046006149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006150 ATP binding site [chemical binding]; other site 365046006151 Mg2+ binding site [ion binding]; other site 365046006152 G-X-G motif; other site 365046006153 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 365046006154 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006156 active site 365046006157 phosphorylation site [posttranslational modification] 365046006158 intermolecular recognition site; other site 365046006159 dimerization interface [polypeptide binding]; other site 365046006160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046006161 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 365046006162 Walker A motif; other site 365046006163 ATP binding site [chemical binding]; other site 365046006164 Walker B motif; other site 365046006165 arginine finger; other site 365046006166 Peptidase family M41; Region: Peptidase_M41; pfam01434 365046006167 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 365046006168 iron-sulfur cluster [ion binding]; other site 365046006169 [2Fe-2S] cluster binding site [ion binding]; other site 365046006170 methionine aminotransferase; Validated; Region: PRK09082 365046006171 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046006172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046006173 homodimer interface [polypeptide binding]; other site 365046006174 catalytic residue [active] 365046006175 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 365046006176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046006177 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 365046006178 substrate binding site [chemical binding]; other site 365046006179 dimerization interface [polypeptide binding]; other site 365046006180 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 365046006181 putative active site [active] 365046006182 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 365046006183 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 365046006184 Predicted permeases [General function prediction only]; Region: COG0795 365046006185 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 365046006186 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 365046006187 interface (dimer of trimers) [polypeptide binding]; other site 365046006188 multifunctional aminopeptidase A; Provisional; Region: PRK00913 365046006189 Substrate-binding/catalytic site; other site 365046006190 Zn-binding sites [ion binding]; other site 365046006191 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 365046006192 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 365046006193 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 365046006194 dimerization interface [polypeptide binding]; other site 365046006195 ligand binding site [chemical binding]; other site 365046006196 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 365046006197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046006198 dimerization interface [polypeptide binding]; other site 365046006199 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046006200 dimerization interface [polypeptide binding]; other site 365046006201 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046006202 dimerization interface [polypeptide binding]; other site 365046006203 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046006204 dimerization interface [polypeptide binding]; other site 365046006205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046006206 dimerization interface [polypeptide binding]; other site 365046006207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046006208 dimerization interface [polypeptide binding]; other site 365046006209 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046006210 GAF domain; Region: GAF; pfam01590 365046006211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006212 dimer interface [polypeptide binding]; other site 365046006213 phosphorylation site [posttranslational modification] 365046006214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006215 ATP binding site [chemical binding]; other site 365046006216 Mg2+ binding site [ion binding]; other site 365046006217 G-X-G motif; other site 365046006218 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006220 active site 365046006221 phosphorylation site [posttranslational modification] 365046006222 intermolecular recognition site; other site 365046006223 dimerization interface [polypeptide binding]; other site 365046006224 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006226 active site 365046006227 phosphorylation site [posttranslational modification] 365046006228 intermolecular recognition site; other site 365046006229 dimerization interface [polypeptide binding]; other site 365046006230 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006232 active site 365046006233 phosphorylation site [posttranslational modification] 365046006234 intermolecular recognition site; other site 365046006235 dimerization interface [polypeptide binding]; other site 365046006236 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046006237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046006238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006239 dimer interface [polypeptide binding]; other site 365046006240 phosphorylation site [posttranslational modification] 365046006241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006242 ATP binding site [chemical binding]; other site 365046006243 Mg2+ binding site [ion binding]; other site 365046006244 G-X-G motif; other site 365046006245 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046006246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006247 active site 365046006248 phosphorylation site [posttranslational modification] 365046006249 intermolecular recognition site; other site 365046006250 dimerization interface [polypeptide binding]; other site 365046006251 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 365046006252 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 365046006253 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 365046006254 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 365046006255 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046006256 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046006257 catalytic residue [active] 365046006258 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 365046006259 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 365046006260 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 365046006261 NAD binding site [chemical binding]; other site 365046006262 homotetramer interface [polypeptide binding]; other site 365046006263 homodimer interface [polypeptide binding]; other site 365046006264 substrate binding site [chemical binding]; other site 365046006265 active site 365046006266 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 365046006267 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 365046006268 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 365046006269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046006270 dimer interface [polypeptide binding]; other site 365046006271 conserved gate region; other site 365046006272 ABC-ATPase subunit interface; other site 365046006273 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 365046006274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046006275 dimer interface [polypeptide binding]; other site 365046006276 conserved gate region; other site 365046006277 putative PBP binding loops; other site 365046006278 ABC-ATPase subunit interface; other site 365046006279 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 365046006280 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 365046006281 Walker A/P-loop; other site 365046006282 ATP binding site [chemical binding]; other site 365046006283 Q-loop/lid; other site 365046006284 ABC transporter signature motif; other site 365046006285 Walker B; other site 365046006286 D-loop; other site 365046006287 H-loop/switch region; other site 365046006288 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 365046006289 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 365046006290 Walker A/P-loop; other site 365046006291 ATP binding site [chemical binding]; other site 365046006292 Q-loop/lid; other site 365046006293 ABC transporter signature motif; other site 365046006294 Walker B; other site 365046006295 D-loop; other site 365046006296 H-loop/switch region; other site 365046006297 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 365046006298 hypothetical protein; Provisional; Region: PRK09256 365046006299 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 365046006300 ribosome maturation protein RimP; Reviewed; Region: PRK00092 365046006301 Sm and related proteins; Region: Sm_like; cl00259 365046006302 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 365046006303 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 365046006304 NusA N-terminal domain; Region: NusA_N; pfam08529 365046006305 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 365046006306 RNA binding site [nucleotide binding]; other site 365046006307 homodimer interface [polypeptide binding]; other site 365046006308 NusA-like KH domain; Region: KH_5; pfam13184 365046006309 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 365046006310 G-X-X-G motif; other site 365046006311 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 365046006312 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 365046006313 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 365046006314 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 365046006315 translation initiation factor IF-2; Region: IF-2; TIGR00487 365046006316 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 365046006317 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 365046006318 G1 box; other site 365046006319 putative GEF interaction site [polypeptide binding]; other site 365046006320 GTP/Mg2+ binding site [chemical binding]; other site 365046006321 Switch I region; other site 365046006322 G2 box; other site 365046006323 G3 box; other site 365046006324 Switch II region; other site 365046006325 G4 box; other site 365046006326 G5 box; other site 365046006327 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 365046006328 Translation-initiation factor 2; Region: IF-2; pfam11987 365046006329 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 365046006330 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 365046006331 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 365046006332 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 365046006333 RNA binding site [nucleotide binding]; other site 365046006334 active site 365046006335 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 365046006336 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 365046006337 G1 box; other site 365046006338 putative GEF interaction site [polypeptide binding]; other site 365046006339 GTP/Mg2+ binding site [chemical binding]; other site 365046006340 Switch I region; other site 365046006341 G2 box; other site 365046006342 G3 box; other site 365046006343 Switch II region; other site 365046006344 G4 box; other site 365046006345 G5 box; other site 365046006346 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 365046006347 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 365046006348 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 365046006349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046006350 substrate binding site [chemical binding]; other site 365046006351 oxyanion hole (OAH) forming residues; other site 365046006352 trimer interface [polypeptide binding]; other site 365046006353 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 365046006354 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 365046006355 SmpB-tmRNA interface; other site 365046006356 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 365046006357 putative coenzyme Q binding site [chemical binding]; other site 365046006358 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 365046006359 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 365046006360 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 365046006361 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 365046006362 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 365046006363 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 365046006364 active site 365046006365 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 365046006366 PIN domain; Region: PIN_3; cl17397 365046006367 GMP synthase; Reviewed; Region: guaA; PRK00074 365046006368 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 365046006369 AMP/PPi binding site [chemical binding]; other site 365046006370 candidate oxyanion hole; other site 365046006371 catalytic triad [active] 365046006372 potential glutamine specificity residues [chemical binding]; other site 365046006373 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 365046006374 ATP Binding subdomain [chemical binding]; other site 365046006375 Ligand Binding sites [chemical binding]; other site 365046006376 Dimerization subdomain; other site 365046006377 Protein of unknown function DUF72; Region: DUF72; pfam01904 365046006378 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 365046006379 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 365046006380 nucleoside/Zn binding site; other site 365046006381 dimer interface [polypeptide binding]; other site 365046006382 catalytic motif [active] 365046006383 haloalkane dehalogenase; Provisional; Region: PRK00870 365046006384 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 365046006385 dimer interface [polypeptide binding]; other site 365046006386 catalytic triad [active] 365046006387 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 365046006388 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 365046006389 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 365046006390 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 365046006391 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 365046006392 active site 365046006393 PilZ domain; Region: PilZ; cl01260 365046006394 DNA polymerase III subunit delta'; Validated; Region: PRK06964 365046006395 DNA polymerase III subunit delta'; Validated; Region: PRK08485 365046006396 thymidylate kinase; Validated; Region: tmk; PRK00698 365046006397 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 365046006398 TMP-binding site; other site 365046006399 ATP-binding site [chemical binding]; other site 365046006400 YceG-like family; Region: YceG; pfam02618 365046006401 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 365046006402 dimerization interface [polypeptide binding]; other site 365046006403 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 365046006404 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 365046006405 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 365046006406 active site 365046006407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046006408 Coenzyme A binding pocket [chemical binding]; other site 365046006409 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 365046006410 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 365046006411 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 365046006412 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 365046006413 putative active site [active] 365046006414 metal binding site [ion binding]; metal-binding site 365046006415 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 365046006416 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 365046006417 active site 365046006418 ATP binding site [chemical binding]; other site 365046006419 substrate binding site [chemical binding]; other site 365046006420 activation loop (A-loop); other site 365046006421 PEGA domain; Region: PEGA; pfam08308 365046006422 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 365046006423 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 365046006424 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 365046006425 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 365046006426 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 365046006427 RNA binding site [nucleotide binding]; other site 365046006428 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 365046006429 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 365046006430 DNA binding site [nucleotide binding] 365046006431 active site 365046006432 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 365046006433 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 365046006434 C-terminal domain interface [polypeptide binding]; other site 365046006435 GSH binding site (G-site) [chemical binding]; other site 365046006436 dimer interface [polypeptide binding]; other site 365046006437 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 365046006438 N-terminal domain interface [polypeptide binding]; other site 365046006439 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046006440 active site 365046006441 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 365046006442 Fatty acid desaturase; Region: FA_desaturase; pfam00487 365046006443 putative di-iron ligands [ion binding]; other site 365046006444 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 365046006445 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 365046006446 Prostaglandin dehydrogenases; Region: PGDH; cd05288 365046006447 NAD(P) binding site [chemical binding]; other site 365046006448 substrate binding site [chemical binding]; other site 365046006449 dimer interface [polypeptide binding]; other site 365046006450 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046006451 CoenzymeA binding site [chemical binding]; other site 365046006452 subunit interaction site [polypeptide binding]; other site 365046006453 PHB binding site; other site 365046006454 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 365046006455 classical (c) SDRs; Region: SDR_c; cd05233 365046006456 NAD(P) binding site [chemical binding]; other site 365046006457 active site 365046006458 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 365046006459 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 365046006460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046006461 active site 365046006462 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 365046006463 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 365046006464 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 365046006465 dimer interface [polypeptide binding]; other site 365046006466 active site 365046006467 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046006468 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 365046006469 substrate binding site [chemical binding]; other site 365046006470 oxyanion hole (OAH) forming residues; other site 365046006471 trimer interface [polypeptide binding]; other site 365046006472 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 365046006473 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 365046006474 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 365046006475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 365046006476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006477 ATP binding site [chemical binding]; other site 365046006478 Mg2+ binding site [ion binding]; other site 365046006479 G-X-G motif; other site 365046006480 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006482 active site 365046006483 phosphorylation site [posttranslational modification] 365046006484 intermolecular recognition site; other site 365046006485 dimerization interface [polypeptide binding]; other site 365046006486 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006488 active site 365046006489 phosphorylation site [posttranslational modification] 365046006490 intermolecular recognition site; other site 365046006491 dimerization interface [polypeptide binding]; other site 365046006492 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 365046006493 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046006494 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046006495 Walker A/P-loop; other site 365046006496 ATP binding site [chemical binding]; other site 365046006497 Q-loop/lid; other site 365046006498 ABC transporter signature motif; other site 365046006499 Walker B; other site 365046006500 D-loop; other site 365046006501 H-loop/switch region; other site 365046006502 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046006503 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046006504 Walker A/P-loop; other site 365046006505 ATP binding site [chemical binding]; other site 365046006506 Q-loop/lid; other site 365046006507 ABC transporter signature motif; other site 365046006508 Walker B; other site 365046006509 D-loop; other site 365046006510 H-loop/switch region; other site 365046006511 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 365046006512 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046006513 TM-ABC transporter signature motif; other site 365046006514 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046006515 TM-ABC transporter signature motif; other site 365046006516 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 365046006517 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 365046006518 putative ligand binding site [chemical binding]; other site 365046006519 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 365046006520 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 365046006521 dimer interface [polypeptide binding]; other site 365046006522 acyl-activating enzyme (AAE) consensus motif; other site 365046006523 putative active site [active] 365046006524 AMP binding site [chemical binding]; other site 365046006525 putative CoA binding site [chemical binding]; other site 365046006526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006527 active site 365046006528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046006529 phosphorylation site [posttranslational modification] 365046006530 intermolecular recognition site; other site 365046006531 dimerization interface [polypeptide binding]; other site 365046006532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006533 dimer interface [polypeptide binding]; other site 365046006534 phosphorylation site [posttranslational modification] 365046006535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006536 ATP binding site [chemical binding]; other site 365046006537 Mg2+ binding site [ion binding]; other site 365046006538 G-X-G motif; other site 365046006539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046006540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006541 dimer interface [polypeptide binding]; other site 365046006542 phosphorylation site [posttranslational modification] 365046006543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006544 ATP binding site [chemical binding]; other site 365046006545 Mg2+ binding site [ion binding]; other site 365046006546 G-X-G motif; other site 365046006547 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006549 active site 365046006550 phosphorylation site [posttranslational modification] 365046006551 intermolecular recognition site; other site 365046006552 dimerization interface [polypeptide binding]; other site 365046006553 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006555 active site 365046006556 phosphorylation site [posttranslational modification] 365046006557 intermolecular recognition site; other site 365046006558 dimerization interface [polypeptide binding]; other site 365046006559 methionine sulfoxide reductase B; Provisional; Region: PRK00222 365046006560 SelR domain; Region: SelR; pfam01641 365046006561 intracellular septation protein A; Reviewed; Region: PRK00259 365046006562 BolA-like protein; Region: BolA; pfam01722 365046006563 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 365046006564 Hemerythrin-like domain; Region: Hr-like; cd12108 365046006565 hydroperoxidase II; Provisional; Region: katE; PRK11249 365046006566 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 365046006567 tetramer interface [polypeptide binding]; other site 365046006568 heme binding pocket [chemical binding]; other site 365046006569 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 365046006570 domain interactions; other site 365046006571 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 365046006572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 365046006573 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 365046006574 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 365046006575 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 365046006576 substrate binding pocket [chemical binding]; other site 365046006577 membrane-bound complex binding site; other site 365046006578 hinge residues; other site 365046006579 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046006580 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 365046006581 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 365046006582 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046006583 potential frameshift: common BLAST hit: gi|264677867|ref|YP_003277773.1| peptidase U32 365046006584 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 365046006585 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 365046006586 Peptidase family U32; Region: Peptidase_U32; pfam01136 365046006587 Collagenase; Region: DUF3656; pfam12392 365046006588 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 365046006589 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 365046006590 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 365046006591 dimerization interface [polypeptide binding]; other site 365046006592 ATP binding site [chemical binding]; other site 365046006593 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 365046006594 dimerization interface [polypeptide binding]; other site 365046006595 ATP binding site [chemical binding]; other site 365046006596 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 365046006597 putative active site [active] 365046006598 catalytic triad [active] 365046006599 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 365046006600 active site 365046006601 PII uridylyl-transferase; Provisional; Region: PRK03059 365046006602 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 365046006603 metal binding triad; other site 365046006604 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 365046006605 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 365046006606 Zn2+ binding site [ion binding]; other site 365046006607 Mg2+ binding site [ion binding]; other site 365046006608 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 365046006609 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 365046006610 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 365046006611 LysR substrate binding domain; Region: LysR_substrate; pfam03466 365046006612 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 365046006613 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 365046006614 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 365046006615 active site residue [active] 365046006616 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 365046006617 active site 365046006618 catalytic residues [active] 365046006619 metal binding site [ion binding]; metal-binding site 365046006620 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 365046006621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046006622 ATP binding site [chemical binding]; other site 365046006623 putative Mg++ binding site [ion binding]; other site 365046006624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046006625 nucleotide binding region [chemical binding]; other site 365046006626 ATP-binding site [chemical binding]; other site 365046006627 Helicase associated domain (HA2); Region: HA2; pfam04408 365046006628 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 365046006629 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 365046006630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 365046006631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 365046006632 metal binding site [ion binding]; metal-binding site 365046006633 active site 365046006634 I-site; other site 365046006635 N-acetylglutamate synthase; Validated; Region: PRK05279 365046006636 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 365046006637 putative feedback inhibition sensing region; other site 365046006638 putative nucleotide binding site [chemical binding]; other site 365046006639 putative substrate binding site [chemical binding]; other site 365046006640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046006641 Coenzyme A binding pocket [chemical binding]; other site 365046006642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 365046006643 active site 365046006644 Erythromycin esterase; Region: Erythro_esteras; pfam05139 365046006645 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 365046006646 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 365046006647 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 365046006648 Walker A/P-loop; other site 365046006649 ATP binding site [chemical binding]; other site 365046006650 Q-loop/lid; other site 365046006651 ABC transporter signature motif; other site 365046006652 Walker B; other site 365046006653 D-loop; other site 365046006654 H-loop/switch region; other site 365046006655 TOBE-like domain; Region: TOBE_3; pfam12857 365046006656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046006657 dimer interface [polypeptide binding]; other site 365046006658 conserved gate region; other site 365046006659 putative PBP binding loops; other site 365046006660 ABC-ATPase subunit interface; other site 365046006661 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 365046006662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046006663 dimer interface [polypeptide binding]; other site 365046006664 conserved gate region; other site 365046006665 putative PBP binding loops; other site 365046006666 ABC-ATPase subunit interface; other site 365046006667 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 365046006668 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 365046006669 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 365046006670 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 365046006671 dimer interface [polypeptide binding]; other site 365046006672 decamer (pentamer of dimers) interface [polypeptide binding]; other site 365046006673 catalytic triad [active] 365046006674 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 365046006675 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 365046006676 Bacterial transcriptional regulator; Region: IclR; pfam01614 365046006677 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 365046006678 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 365046006679 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 365046006680 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 365046006681 active site 365046006682 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046006683 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046006684 Sensors of blue-light using FAD; Region: BLUF; pfam04940 365046006685 hypothetical protein; Provisional; Region: PRK01254 365046006686 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 365046006687 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 365046006688 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 365046006689 intracellular protease, PfpI family; Region: PfpI; TIGR01382 365046006690 proposed catalytic triad [active] 365046006691 conserved cys residue [active] 365046006692 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 365046006693 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 365046006694 metal binding site [ion binding]; metal-binding site 365046006695 cyclase homology domain; Region: CHD; cd07302 365046006696 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 365046006697 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 365046006698 putative catalytic site [active] 365046006699 putative phosphate binding site [ion binding]; other site 365046006700 active site 365046006701 metal binding site A [ion binding]; metal-binding site 365046006702 DNA binding site [nucleotide binding] 365046006703 putative AP binding site [nucleotide binding]; other site 365046006704 putative metal binding site B [ion binding]; other site 365046006705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046006706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006707 ATP binding site [chemical binding]; other site 365046006708 Mg2+ binding site [ion binding]; other site 365046006709 G-X-G motif; other site 365046006710 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006712 active site 365046006713 phosphorylation site [posttranslational modification] 365046006714 intermolecular recognition site; other site 365046006715 dimerization interface [polypeptide binding]; other site 365046006716 DEAD-like helicases superfamily; Region: DEXDc2; smart00488 365046006717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 365046006718 DEAD_2; Region: DEAD_2; pfam06733 365046006719 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 365046006720 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 365046006721 YCII-related domain; Region: YCII; cl00999 365046006722 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 365046006723 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 365046006724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046006725 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 365046006726 putative dimerization interface [polypeptide binding]; other site 365046006727 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 365046006728 Domain of unknown function (DUF897); Region: DUF897; cl01312 365046006729 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006731 active site 365046006732 phosphorylation site [posttranslational modification] 365046006733 intermolecular recognition site; other site 365046006734 dimerization interface [polypeptide binding]; other site 365046006735 PAS fold; Region: PAS; pfam00989 365046006736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 365046006737 putative active site [active] 365046006738 heme pocket [chemical binding]; other site 365046006739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046006740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006741 dimer interface [polypeptide binding]; other site 365046006742 phosphorylation site [posttranslational modification] 365046006743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006744 ATP binding site [chemical binding]; other site 365046006745 Mg2+ binding site [ion binding]; other site 365046006746 G-X-G motif; other site 365046006747 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006749 active site 365046006750 phosphorylation site [posttranslational modification] 365046006751 intermolecular recognition site; other site 365046006752 dimerization interface [polypeptide binding]; other site 365046006753 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 365046006754 dinuclear metal binding motif [ion binding]; other site 365046006755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046006756 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046006757 putative active site [active] 365046006758 heme pocket [chemical binding]; other site 365046006759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006760 dimer interface [polypeptide binding]; other site 365046006761 phosphorylation site [posttranslational modification] 365046006762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006763 ATP binding site [chemical binding]; other site 365046006764 Mg2+ binding site [ion binding]; other site 365046006765 G-X-G motif; other site 365046006766 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 365046006767 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 365046006768 nucleotide binding pocket [chemical binding]; other site 365046006769 K-X-D-G motif; other site 365046006770 catalytic site [active] 365046006771 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 365046006772 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 365046006773 Helix-hairpin-helix motif; Region: HHH; pfam00633 365046006774 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 365046006775 BRCT sequence motif; other site 365046006776 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 365046006777 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 365046006778 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 365046006779 Walker A/P-loop; other site 365046006780 ATP binding site [chemical binding]; other site 365046006781 Q-loop/lid; other site 365046006782 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 365046006783 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 365046006784 ABC transporter signature motif; other site 365046006785 Walker B; other site 365046006786 D-loop; other site 365046006787 H-loop/switch region; other site 365046006788 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 365046006789 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 365046006790 classical (c) SDRs; Region: SDR_c; cd05233 365046006791 NAD(P) binding site [chemical binding]; other site 365046006792 active site 365046006793 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 365046006794 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046006795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046006796 homodimer interface [polypeptide binding]; other site 365046006797 catalytic residue [active] 365046006798 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 365046006799 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 365046006800 active site 365046006801 substrate binding site [chemical binding]; other site 365046006802 trimer interface [polypeptide binding]; other site 365046006803 CoA binding site [chemical binding]; other site 365046006804 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 365046006805 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 365046006806 Walker A motif; other site 365046006807 ATP binding site [chemical binding]; other site 365046006808 Walker B motif; other site 365046006809 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 365046006810 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 365046006811 metal binding site [ion binding]; metal-binding site 365046006812 dimer interface [polypeptide binding]; other site 365046006813 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 365046006814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046006815 S-adenosylmethionine binding site [chemical binding]; other site 365046006816 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 365046006817 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 365046006818 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 365046006819 ABC transporter; Region: ABC_tran_2; pfam12848 365046006820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 365046006821 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 365046006822 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 365046006823 putative ATP binding site [chemical binding]; other site 365046006824 putative substrate interface [chemical binding]; other site 365046006825 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 365046006826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 365046006827 TPR motif; other site 365046006828 binding surface 365046006829 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 365046006830 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 365046006831 ligand binding site [chemical binding]; other site 365046006832 translocation protein TolB; Provisional; Region: tolB; PRK02889 365046006833 TolB amino-terminal domain; Region: TolB_N; pfam04052 365046006834 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 365046006835 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 365046006836 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 365046006837 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 365046006838 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 365046006839 Substrate binding site; other site 365046006840 metal-binding site 365046006841 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 365046006842 putative metal binding site; other site 365046006843 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 365046006844 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 365046006845 NAD binding site [chemical binding]; other site 365046006846 homodimer interface [polypeptide binding]; other site 365046006847 active site 365046006848 substrate binding site [chemical binding]; other site 365046006849 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 365046006850 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 365046006851 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 365046006852 Walker A/P-loop; other site 365046006853 ATP binding site [chemical binding]; other site 365046006854 Q-loop/lid; other site 365046006855 ABC transporter signature motif; other site 365046006856 Walker B; other site 365046006857 D-loop; other site 365046006858 H-loop/switch region; other site 365046006859 ribonuclease G; Provisional; Region: PRK11712 365046006860 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 365046006861 homodimer interface [polypeptide binding]; other site 365046006862 oligonucleotide binding site [chemical binding]; other site 365046006863 PAS domain; Region: PAS_9; pfam13426 365046006864 Maf-like protein; Region: Maf; pfam02545 365046006865 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 365046006866 active site 365046006867 dimer interface [polypeptide binding]; other site 365046006868 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 365046006869 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 365046006870 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 365046006871 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 365046006872 active site 365046006873 (T/H)XGH motif; other site 365046006874 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 365046006875 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 365046006876 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 365046006877 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 365046006878 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 365046006879 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 365046006880 hypothetical protein; Validated; Region: PRK00110 365046006881 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 365046006882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 365046006883 Walker A motif; other site 365046006884 ATP binding site [chemical binding]; other site 365046006885 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 365046006886 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 365046006887 tetramer interface [polypeptide binding]; other site 365046006888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046006889 catalytic residue [active] 365046006890 hypothetical protein; Validated; Region: PRK07198 365046006891 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 365046006892 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 365046006893 dimerization interface [polypeptide binding]; other site 365046006894 active site 365046006895 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 365046006896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 365046006897 active site 365046006898 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 365046006899 MltA-interacting protein MipA; Region: MipA; cl01504 365046006900 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 365046006901 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 365046006902 putative ligand binding site [chemical binding]; other site 365046006903 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 365046006904 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 365046006905 Walker A/P-loop; other site 365046006906 ATP binding site [chemical binding]; other site 365046006907 Q-loop/lid; other site 365046006908 ABC transporter signature motif; other site 365046006909 Walker B; other site 365046006910 D-loop; other site 365046006911 H-loop/switch region; other site 365046006912 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 365046006913 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 365046006914 TM-ABC transporter signature motif; other site 365046006915 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046006916 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 365046006917 TM-ABC transporter signature motif; other site 365046006918 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 365046006919 Helix-turn-helix domain; Region: HTH_18; pfam12833 365046006920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046006921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046006922 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 365046006923 cytosine deaminase; Validated; Region: PRK07572 365046006924 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 365046006925 active site 365046006926 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 365046006927 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 365046006928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046006929 ATP binding site [chemical binding]; other site 365046006930 putative Mg++ binding site [ion binding]; other site 365046006931 CcdB protein; Region: CcdB; cl03380 365046006932 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 365046006933 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 365046006934 putative active site [active] 365046006935 GIY-YIG motif/motif A; other site 365046006936 putative metal binding site [ion binding]; other site 365046006937 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 365046006938 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 365046006939 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 365046006940 HsdM N-terminal domain; Region: HsdM_N; pfam12161 365046006941 Methyltransferase domain; Region: Methyltransf_26; pfam13659 365046006942 Major royal jelly protein; Region: MRJP; pfam03022 365046006943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046006944 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046006945 putative active site [active] 365046006946 heme pocket [chemical binding]; other site 365046006947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006948 dimer interface [polypeptide binding]; other site 365046006949 phosphorylation site [posttranslational modification] 365046006950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006951 ATP binding site [chemical binding]; other site 365046006952 Mg2+ binding site [ion binding]; other site 365046006953 G-X-G motif; other site 365046006954 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006956 active site 365046006957 phosphorylation site [posttranslational modification] 365046006958 intermolecular recognition site; other site 365046006959 dimerization interface [polypeptide binding]; other site 365046006960 PAS fold; Region: PAS_4; pfam08448 365046006961 PAS domain S-box; Region: sensory_box; TIGR00229 365046006962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046006963 putative active site [active] 365046006964 heme pocket [chemical binding]; other site 365046006965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046006966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006967 dimer interface [polypeptide binding]; other site 365046006968 phosphorylation site [posttranslational modification] 365046006969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006970 ATP binding site [chemical binding]; other site 365046006971 Mg2+ binding site [ion binding]; other site 365046006972 G-X-G motif; other site 365046006973 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006975 active site 365046006976 phosphorylation site [posttranslational modification] 365046006977 intermolecular recognition site; other site 365046006978 dimerization interface [polypeptide binding]; other site 365046006979 PAS domain S-box; Region: sensory_box; TIGR00229 365046006980 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 365046006981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046006982 PAS fold; Region: PAS_3; pfam08447 365046006983 putative active site [active] 365046006984 heme pocket [chemical binding]; other site 365046006985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046006986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046006987 dimer interface [polypeptide binding]; other site 365046006988 phosphorylation site [posttranslational modification] 365046006989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046006990 ATP binding site [chemical binding]; other site 365046006991 Mg2+ binding site [ion binding]; other site 365046006992 G-X-G motif; other site 365046006993 Response regulator receiver domain; Region: Response_reg; pfam00072 365046006994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046006995 active site 365046006996 phosphorylation site [posttranslational modification] 365046006997 intermolecular recognition site; other site 365046006998 dimerization interface [polypeptide binding]; other site 365046006999 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 365046007000 putative hydrophobic ligand binding site [chemical binding]; other site 365046007001 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 365046007002 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 365046007003 putative hydrophobic ligand binding site [chemical binding]; other site 365046007004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046007005 dimerization interface [polypeptide binding]; other site 365046007006 putative DNA binding site [nucleotide binding]; other site 365046007007 putative Zn2+ binding site [ion binding]; other site 365046007008 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 365046007009 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 365046007010 C-terminal domain interface [polypeptide binding]; other site 365046007011 GSH binding site (G-site) [chemical binding]; other site 365046007012 dimer interface [polypeptide binding]; other site 365046007013 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 365046007014 N-terminal domain interface [polypeptide binding]; other site 365046007015 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 365046007016 Transcriptional regulators [Transcription]; Region: FadR; COG2186 365046007017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046007018 DNA-binding site [nucleotide binding]; DNA binding site 365046007019 FCD domain; Region: FCD; pfam07729 365046007020 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 365046007021 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 365046007022 ligand binding site [chemical binding]; other site 365046007023 NAD binding site [chemical binding]; other site 365046007024 dimerization interface [polypeptide binding]; other site 365046007025 catalytic site [active] 365046007026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046007027 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 365046007028 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 365046007029 inhibitor site; inhibition site 365046007030 active site 365046007031 dimer interface [polypeptide binding]; other site 365046007032 catalytic residue [active] 365046007033 hypothetical protein; Validated; Region: PRK08245 365046007034 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 365046007035 active site 365046007036 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 365046007037 dimer interface [polypeptide binding]; other site 365046007038 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 365046007039 pentamer interface [polypeptide binding]; other site 365046007040 dodecaamer interface [polypeptide binding]; other site 365046007041 Hemerythrin-like domain; Region: Hr-like; cd12108 365046007042 Fe binding site [ion binding]; other site 365046007043 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 365046007044 substrate binding pocket [chemical binding]; other site 365046007045 active site 365046007046 iron coordination sites [ion binding]; other site 365046007047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046007048 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 365046007049 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 365046007050 substrate binding site [chemical binding]; other site 365046007051 isopropylmalate isomerase large subunit; Provisional; Region: PRK12466 365046007052 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 365046007053 substrate binding site [chemical binding]; other site 365046007054 ligand binding site [chemical binding]; other site 365046007055 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 365046007056 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 365046007057 tetramer interface [polypeptide binding]; other site 365046007058 active site 365046007059 Mg2+/Mn2+ binding site [ion binding]; other site 365046007060 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 365046007061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046007062 DNA-binding site [nucleotide binding]; DNA binding site 365046007063 UTRA domain; Region: UTRA; pfam07702 365046007064 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046007065 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046007066 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046007067 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 365046007068 active site 365046007069 catalytic residues [active] 365046007070 metal binding site [ion binding]; metal-binding site 365046007071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046007072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046007073 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 365046007074 putative dimerization interface [polypeptide binding]; other site 365046007075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046007076 PAS domain; Region: PAS_9; pfam13426 365046007077 putative active site [active] 365046007078 heme pocket [chemical binding]; other site 365046007079 PAS domain S-box; Region: sensory_box; TIGR00229 365046007080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046007081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046007082 dimer interface [polypeptide binding]; other site 365046007083 phosphorylation site [posttranslational modification] 365046007084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046007085 ATP binding site [chemical binding]; other site 365046007086 Mg2+ binding site [ion binding]; other site 365046007087 G-X-G motif; other site 365046007088 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046007089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046007090 active site 365046007091 phosphorylation site [posttranslational modification] 365046007092 intermolecular recognition site; other site 365046007093 dimerization interface [polypeptide binding]; other site 365046007094 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 365046007095 maleylacetoacetate isomerase; Region: maiA; TIGR01262 365046007096 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 365046007097 C-terminal domain interface [polypeptide binding]; other site 365046007098 GSH binding site (G-site) [chemical binding]; other site 365046007099 putative dimer interface [polypeptide binding]; other site 365046007100 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 365046007101 N-terminal domain interface [polypeptide binding]; other site 365046007102 dimer interface [polypeptide binding]; other site 365046007103 substrate binding pocket (H-site) [chemical binding]; other site 365046007104 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 365046007105 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 365046007106 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 365046007107 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 365046007108 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 365046007109 EVE domain; Region: EVE; cl00728 365046007110 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 365046007111 Clp amino terminal domain; Region: Clp_N; pfam02861 365046007112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046007113 Walker A motif; other site 365046007114 ATP binding site [chemical binding]; other site 365046007115 Walker B motif; other site 365046007116 arginine finger; other site 365046007117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046007118 Walker A motif; other site 365046007119 ATP binding site [chemical binding]; other site 365046007120 Walker B motif; other site 365046007121 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 365046007122 Uncharacterized conserved protein [Function unknown]; Region: COG2127 365046007123 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 365046007124 DNA-binding site [nucleotide binding]; DNA binding site 365046007125 RNA-binding motif; other site 365046007126 isocitrate dehydrogenase; Validated; Region: PRK07362 365046007127 isocitrate dehydrogenase; Reviewed; Region: PRK07006 365046007128 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 365046007129 superoxide dismutase; Provisional; Region: PRK10543 365046007130 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 365046007131 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 365046007132 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 365046007133 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 365046007134 generic binding surface II; other site 365046007135 generic binding surface I; other site 365046007136 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 365046007137 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 365046007138 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 365046007139 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 365046007140 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 365046007141 Uncharacterized conserved protein [Function unknown]; Region: COG2835 365046007142 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 365046007143 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 365046007144 Ligand binding site; other site 365046007145 oligomer interface; other site 365046007146 adenylate kinase; Reviewed; Region: adk; PRK00279 365046007147 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 365046007148 AMP-binding site [chemical binding]; other site 365046007149 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 365046007150 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 365046007151 active site 365046007152 homodimer interface [polypeptide binding]; other site 365046007153 homotetramer interface [polypeptide binding]; other site 365046007154 LexA repressor; Validated; Region: PRK00215 365046007155 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 365046007156 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 365046007157 Catalytic site [active] 365046007158 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 365046007159 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 365046007160 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 365046007161 dimerization interface [polypeptide binding]; other site 365046007162 NAD binding site [chemical binding]; other site 365046007163 ligand binding site [chemical binding]; other site 365046007164 catalytic site [active] 365046007165 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 365046007166 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 365046007167 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 365046007168 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 365046007169 enoyl-CoA hydratase; Provisional; Region: PRK07511 365046007170 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046007171 substrate binding site [chemical binding]; other site 365046007172 oxyanion hole (OAH) forming residues; other site 365046007173 trimer interface [polypeptide binding]; other site 365046007174 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 365046007175 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 365046007176 ligand binding site [chemical binding]; other site 365046007177 flexible hinge region; other site 365046007178 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 365046007179 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 365046007180 Phosphotransferase enzyme family; Region: APH; pfam01636 365046007181 putative active site [active] 365046007182 putative substrate binding site [chemical binding]; other site 365046007183 ATP binding site [chemical binding]; other site 365046007184 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 365046007185 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046007186 active site 365046007187 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 365046007188 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 365046007189 dimer interface [polypeptide binding]; other site 365046007190 GSH binding site (G-site) [chemical binding]; other site 365046007191 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 365046007192 N-terminal domain interface [polypeptide binding]; other site 365046007193 putative dimer interface [polypeptide binding]; other site 365046007194 active site 365046007195 Acyltransferase family; Region: Acyl_transf_3; pfam01757 365046007196 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 365046007197 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 365046007198 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 365046007199 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 365046007200 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 365046007201 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 365046007202 Outer membrane efflux protein; Region: OEP; pfam02321 365046007203 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 365046007204 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 365046007205 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 365046007206 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 365046007207 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 365046007208 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 365046007209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046007210 ATP binding site [chemical binding]; other site 365046007211 Mg2+ binding site [ion binding]; other site 365046007212 G-X-G motif; other site 365046007213 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 365046007214 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 365046007215 ATP binding site [chemical binding]; other site 365046007216 Mg2+ binding site [ion binding]; other site 365046007217 G-X-G motif; other site 365046007218 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 365046007219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046007220 dimer interface [polypeptide binding]; other site 365046007221 phosphorylation site [posttranslational modification] 365046007222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046007223 ATP binding site [chemical binding]; other site 365046007224 Mg2+ binding site [ion binding]; other site 365046007225 G-X-G motif; other site 365046007226 Response regulator receiver domain; Region: Response_reg; pfam00072 365046007227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046007228 active site 365046007229 phosphorylation site [posttranslational modification] 365046007230 intermolecular recognition site; other site 365046007231 dimerization interface [polypeptide binding]; other site 365046007232 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046007233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046007234 putative active site [active] 365046007235 heme pocket [chemical binding]; other site 365046007236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046007237 dimer interface [polypeptide binding]; other site 365046007238 phosphorylation site [posttranslational modification] 365046007239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046007240 ATP binding site [chemical binding]; other site 365046007241 Mg2+ binding site [ion binding]; other site 365046007242 G-X-G motif; other site 365046007243 Response regulator receiver domain; Region: Response_reg; pfam00072 365046007244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046007245 active site 365046007246 phosphorylation site [posttranslational modification] 365046007247 intermolecular recognition site; other site 365046007248 dimerization interface [polypeptide binding]; other site 365046007249 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 365046007250 HicB family; Region: HicB; pfam05534 365046007251 Protein of unknown function, DUF488; Region: DUF488; cl01246 365046007252 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 365046007253 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 365046007254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046007255 substrate binding site [chemical binding]; other site 365046007256 oxyanion hole (OAH) forming residues; other site 365046007257 trimer interface [polypeptide binding]; other site 365046007258 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046007259 substrate binding site [chemical binding]; other site 365046007260 trimer interface [polypeptide binding]; other site 365046007261 oxyanion hole (OAH) forming residues; other site 365046007262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046007263 non-specific DNA binding site [nucleotide binding]; other site 365046007264 salt bridge; other site 365046007265 sequence-specific DNA binding site [nucleotide binding]; other site 365046007266 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 365046007267 AAA domain; Region: AAA_33; pfam13671 365046007268 ADP binding site [chemical binding]; other site 365046007269 magnesium binding site [ion binding]; other site 365046007270 putative shikimate binding site; other site 365046007271 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 365046007272 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 365046007273 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 365046007274 dimer interface [polypeptide binding]; other site 365046007275 acyl-activating enzyme (AAE) consensus motif; other site 365046007276 putative active site [active] 365046007277 putative AMP binding site [chemical binding]; other site 365046007278 putative CoA binding site [chemical binding]; other site 365046007279 chemical substrate binding site [chemical binding]; other site 365046007280 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 365046007281 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 365046007282 putative ligand binding site [chemical binding]; other site 365046007283 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046007284 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046007285 TM-ABC transporter signature motif; other site 365046007286 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 365046007287 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046007288 TM-ABC transporter signature motif; other site 365046007289 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046007290 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046007291 Walker A/P-loop; other site 365046007292 ATP binding site [chemical binding]; other site 365046007293 Q-loop/lid; other site 365046007294 ABC transporter signature motif; other site 365046007295 Walker B; other site 365046007296 D-loop; other site 365046007297 H-loop/switch region; other site 365046007298 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046007299 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046007300 Walker A/P-loop; other site 365046007301 ATP binding site [chemical binding]; other site 365046007302 Q-loop/lid; other site 365046007303 ABC transporter signature motif; other site 365046007304 Walker B; other site 365046007305 D-loop; other site 365046007306 H-loop/switch region; other site 365046007307 KTSC domain; Region: KTSC; pfam13619 365046007308 Predicted flavoprotein [General function prediction only]; Region: COG0431 365046007309 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 365046007310 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 365046007311 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046007312 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 365046007313 active site 365046007314 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 365046007315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046007316 Walker A/P-loop; other site 365046007317 ATP binding site [chemical binding]; other site 365046007318 Q-loop/lid; other site 365046007319 ABC transporter signature motif; other site 365046007320 Walker B; other site 365046007321 D-loop; other site 365046007322 H-loop/switch region; other site 365046007323 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 365046007324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046007325 Walker A/P-loop; other site 365046007326 ATP binding site [chemical binding]; other site 365046007327 Q-loop/lid; other site 365046007328 ABC transporter signature motif; other site 365046007329 Walker B; other site 365046007330 D-loop; other site 365046007331 H-loop/switch region; other site 365046007332 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 365046007333 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 365046007334 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 365046007335 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 365046007336 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 365046007337 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 365046007338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046007339 DNA-binding site [nucleotide binding]; DNA binding site 365046007340 UTRA domain; Region: UTRA; pfam07702 365046007341 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 365046007342 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 365046007343 active site 365046007344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046007345 Coenzyme A binding pocket [chemical binding]; other site 365046007346 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 365046007347 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 365046007348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046007349 dimer interface [polypeptide binding]; other site 365046007350 conserved gate region; other site 365046007351 putative PBP binding loops; other site 365046007352 ABC-ATPase subunit interface; other site 365046007353 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 365046007354 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 365046007355 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 365046007356 Walker A/P-loop; other site 365046007357 ATP binding site [chemical binding]; other site 365046007358 Q-loop/lid; other site 365046007359 ABC transporter signature motif; other site 365046007360 Walker B; other site 365046007361 D-loop; other site 365046007362 H-loop/switch region; other site 365046007363 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 365046007364 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 365046007365 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 365046007366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 365046007367 substrate binding pocket [chemical binding]; other site 365046007368 membrane-bound complex binding site; other site 365046007369 hinge residues; other site 365046007370 oxidative damage protection protein; Provisional; Region: PRK05408 365046007371 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 365046007372 Uncharacterized conserved protein [Function unknown]; Region: COG4121 365046007373 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 365046007374 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 365046007375 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 365046007376 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 365046007377 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 365046007378 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 365046007379 Active Sites [active] 365046007380 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 365046007381 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 365046007382 Active Sites [active] 365046007383 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 365046007384 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 365046007385 G1 box; other site 365046007386 GTP/Mg2+ binding site [chemical binding]; other site 365046007387 G2 box; other site 365046007388 Switch I region; other site 365046007389 G3 box; other site 365046007390 Switch II region; other site 365046007391 G4 box; other site 365046007392 G5 box; other site 365046007393 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 365046007394 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 365046007395 Ferredoxin [Energy production and conversion]; Region: COG1146 365046007396 4Fe-4S binding domain; Region: Fer4; cl02805 365046007397 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 365046007398 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 365046007399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046007400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046007401 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 365046007402 ThiS interaction site; other site 365046007403 putative active site [active] 365046007404 tetramer interface [polypeptide binding]; other site 365046007405 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 365046007406 thiS-thiF/thiG interaction site; other site 365046007407 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 365046007408 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 365046007409 thiamine phosphate binding site [chemical binding]; other site 365046007410 active site 365046007411 pyrophosphate binding site [ion binding]; other site 365046007412 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 365046007413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046007414 NAD(P) binding site [chemical binding]; other site 365046007415 active site 365046007416 NMT1/THI5 like; Region: NMT1; pfam09084 365046007417 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 365046007418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046007419 dimer interface [polypeptide binding]; other site 365046007420 conserved gate region; other site 365046007421 ABC-ATPase subunit interface; other site 365046007422 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 365046007423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046007424 Walker A/P-loop; other site 365046007425 ATP binding site [chemical binding]; other site 365046007426 Q-loop/lid; other site 365046007427 ABC transporter signature motif; other site 365046007428 Walker B; other site 365046007429 D-loop; other site 365046007430 H-loop/switch region; other site 365046007431 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 365046007432 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 365046007433 putative catalytic cysteine [active] 365046007434 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 365046007435 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 365046007436 dimer interface [polypeptide binding]; other site 365046007437 substrate binding site [chemical binding]; other site 365046007438 ATP binding site [chemical binding]; other site 365046007439 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 365046007440 active site 365046007441 putative substrate binding region [chemical binding]; other site 365046007442 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046007443 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 365046007444 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046007445 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 365046007446 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046007447 Outer membrane efflux protein; Region: OEP; pfam02321 365046007448 Outer membrane efflux protein; Region: OEP; pfam02321 365046007449 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 365046007450 VCBS repeat; Region: VCBS_repeat; TIGR01965 365046007451 VCBS repeat; Region: VCBS_repeat; TIGR01965 365046007452 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 365046007453 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 365046007454 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 365046007455 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 365046007456 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 365046007457 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 365046007458 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 365046007459 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 365046007460 Transcriptional regulator [Transcription]; Region: IclR; COG1414 365046007461 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 365046007462 Bacterial transcriptional regulator; Region: IclR; pfam01614 365046007463 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 365046007464 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 365046007465 2-isopropylmalate synthase; Validated; Region: PRK00915 365046007466 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 365046007467 active site 365046007468 catalytic residues [active] 365046007469 metal binding site [ion binding]; metal-binding site 365046007470 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 365046007471 2-isopropylmalate synthase; Validated; Region: PRK03739 365046007472 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 365046007473 active site 365046007474 catalytic residues [active] 365046007475 metal binding site [ion binding]; metal-binding site 365046007476 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 365046007477 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 365046007478 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 365046007479 ketol-acid reductoisomerase; Provisional; Region: PRK05479 365046007480 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 365046007481 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 365046007482 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 365046007483 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 365046007484 putative valine binding site [chemical binding]; other site 365046007485 dimer interface [polypeptide binding]; other site 365046007486 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 365046007487 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 365046007488 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 365046007489 PYR/PP interface [polypeptide binding]; other site 365046007490 dimer interface [polypeptide binding]; other site 365046007491 TPP binding site [chemical binding]; other site 365046007492 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 365046007493 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 365046007494 TPP-binding site [chemical binding]; other site 365046007495 dimer interface [polypeptide binding]; other site 365046007496 RNA polymerase factor sigma-70; Validated; Region: PRK09047 365046007497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 365046007498 DNA binding residues [nucleotide binding] 365046007499 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 365046007500 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 365046007501 RDD family; Region: RDD; pfam06271 365046007502 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 365046007503 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 365046007504 Nitrogen regulatory protein P-II; Region: P-II; smart00938 365046007505 NAD synthetase; Provisional; Region: PRK13981 365046007506 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 365046007507 active site 365046007508 catalytic triad [active] 365046007509 multimer interface [polypeptide binding]; other site 365046007510 protein interface 1 [polypeptide binding]; other site 365046007511 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 365046007512 homodimer interface [polypeptide binding]; other site 365046007513 NAD binding pocket [chemical binding]; other site 365046007514 ATP binding pocket [chemical binding]; other site 365046007515 Mg binding site [ion binding]; other site 365046007516 active-site loop [active] 365046007517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 365046007518 Protein of unknown function, DUF482; Region: DUF482; pfam04339 365046007519 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 365046007520 dimer interface [polypeptide binding]; other site 365046007521 substrate binding site [chemical binding]; other site 365046007522 metal binding sites [ion binding]; metal-binding site 365046007523 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 365046007524 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 365046007525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 365046007526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046007527 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 365046007528 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 365046007529 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 365046007530 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 365046007531 NAD(P) binding site [chemical binding]; other site 365046007532 catalytic residues [active] 365046007533 catalytic residues [active] 365046007534 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 365046007535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046007536 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 365046007537 NAD(P) binding site [chemical binding]; other site 365046007538 active site 365046007539 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 365046007540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 365046007541 FeS/SAM binding site; other site 365046007542 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 365046007543 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 365046007544 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 365046007545 GTP binding site; other site 365046007546 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 365046007547 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 365046007548 dimer interface [polypeptide binding]; other site 365046007549 putative functional site; other site 365046007550 putative MPT binding site; other site 365046007551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046007552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046007553 dimer interface [polypeptide binding]; other site 365046007554 phosphorylation site [posttranslational modification] 365046007555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046007556 ATP binding site [chemical binding]; other site 365046007557 Mg2+ binding site [ion binding]; other site 365046007558 G-X-G motif; other site 365046007559 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 365046007560 active site 365046007561 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 365046007562 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 365046007563 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 365046007564 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046007565 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 365046007566 RNA/DNA hybrid binding site [nucleotide binding]; other site 365046007567 active site 365046007568 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 365046007569 Methyltransferase domain; Region: Methyltransf_11; pfam08241 365046007570 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 365046007571 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 365046007572 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 365046007573 N-acetyl-D-glucosamine binding site [chemical binding]; other site 365046007574 catalytic residue [active] 365046007575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 365046007576 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 365046007577 NMT1/THI5 like; Region: NMT1; pfam09084 365046007578 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 365046007579 membrane-bound complex binding site; other site 365046007580 hinge residues; other site 365046007581 MAPEG family; Region: MAPEG; cl09190 365046007582 recombination protein RecR; Reviewed; Region: recR; PRK00076 365046007583 RecR protein; Region: RecR; pfam02132 365046007584 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 365046007585 putative active site [active] 365046007586 putative metal-binding site [ion binding]; other site 365046007587 tetramer interface [polypeptide binding]; other site 365046007588 hypothetical protein; Validated; Region: PRK00153 365046007589 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 365046007590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046007591 Walker A motif; other site 365046007592 ATP binding site [chemical binding]; other site 365046007593 Walker B motif; other site 365046007594 arginine finger; other site 365046007595 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 365046007596 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046007597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046007598 active site 365046007599 phosphorylation site [posttranslational modification] 365046007600 intermolecular recognition site; other site 365046007601 dimerization interface [polypeptide binding]; other site 365046007602 HEAT repeats; Region: HEAT_2; pfam13646 365046007603 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 365046007604 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 365046007605 DXD motif; other site 365046007606 CHASE domain; Region: CHASE; pfam03924 365046007607 PAS domain; Region: PAS_9; pfam13426 365046007608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046007609 putative active site [active] 365046007610 heme pocket [chemical binding]; other site 365046007611 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046007612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046007613 putative active site [active] 365046007614 heme pocket [chemical binding]; other site 365046007615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046007616 dimer interface [polypeptide binding]; other site 365046007617 phosphorylation site [posttranslational modification] 365046007618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046007619 ATP binding site [chemical binding]; other site 365046007620 Mg2+ binding site [ion binding]; other site 365046007621 G-X-G motif; other site 365046007622 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046007623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046007624 active site 365046007625 phosphorylation site [posttranslational modification] 365046007626 dimerization interface [polypeptide binding]; other site 365046007627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046007628 Response regulator receiver domain; Region: Response_reg; pfam00072 365046007629 active site 365046007630 phosphorylation site [posttranslational modification] 365046007631 intermolecular recognition site; other site 365046007632 dimerization interface [polypeptide binding]; other site 365046007633 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 365046007634 putative binding surface; other site 365046007635 active site 365046007636 HAMP domain; Region: HAMP; pfam00672 365046007637 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046007638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046007639 putative active site [active] 365046007640 heme pocket [chemical binding]; other site 365046007641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046007642 dimer interface [polypeptide binding]; other site 365046007643 phosphorylation site [posttranslational modification] 365046007644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046007645 ATP binding site [chemical binding]; other site 365046007646 Mg2+ binding site [ion binding]; other site 365046007647 G-X-G motif; other site 365046007648 Response regulator receiver domain; Region: Response_reg; pfam00072 365046007649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046007650 active site 365046007651 phosphorylation site [posttranslational modification] 365046007652 intermolecular recognition site; other site 365046007653 dimerization interface [polypeptide binding]; other site 365046007654 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 365046007655 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 365046007656 Part of AAA domain; Region: AAA_19; pfam13245 365046007657 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 365046007658 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 365046007659 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 365046007660 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 365046007661 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 365046007662 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 365046007663 catalytic residues [active] 365046007664 transcription termination factor Rho; Provisional; Region: rho; PRK09376 365046007665 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 365046007666 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 365046007667 RNA binding site [nucleotide binding]; other site 365046007668 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 365046007669 multimer interface [polypeptide binding]; other site 365046007670 Walker A motif; other site 365046007671 ATP binding site [chemical binding]; other site 365046007672 Walker B motif; other site 365046007673 Ferritin-like domain; Region: Ferritin; pfam00210 365046007674 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 365046007675 dimerization interface [polypeptide binding]; other site 365046007676 DPS ferroxidase diiron center [ion binding]; other site 365046007677 ion pore; other site 365046007678 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 365046007679 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 365046007680 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046007681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046007682 putative active site [active] 365046007683 heme pocket [chemical binding]; other site 365046007684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046007685 dimer interface [polypeptide binding]; other site 365046007686 phosphorylation site [posttranslational modification] 365046007687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046007688 ATP binding site [chemical binding]; other site 365046007689 Mg2+ binding site [ion binding]; other site 365046007690 G-X-G motif; other site 365046007691 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 365046007692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046007693 active site 365046007694 phosphorylation site [posttranslational modification] 365046007695 intermolecular recognition site; other site 365046007696 dimerization interface [polypeptide binding]; other site 365046007697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046007698 DNA binding site [nucleotide binding] 365046007699 transcriptional regulator PhoU; Provisional; Region: PRK11115 365046007700 PhoU domain; Region: PhoU; pfam01895 365046007701 PhoU domain; Region: PhoU; pfam01895 365046007702 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 365046007703 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 365046007704 Walker A/P-loop; other site 365046007705 ATP binding site [chemical binding]; other site 365046007706 Q-loop/lid; other site 365046007707 ABC transporter signature motif; other site 365046007708 Walker B; other site 365046007709 D-loop; other site 365046007710 H-loop/switch region; other site 365046007711 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 365046007712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046007713 dimer interface [polypeptide binding]; other site 365046007714 conserved gate region; other site 365046007715 putative PBP binding loops; other site 365046007716 ABC-ATPase subunit interface; other site 365046007717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046007718 dimer interface [polypeptide binding]; other site 365046007719 conserved gate region; other site 365046007720 putative PBP binding loops; other site 365046007721 ABC-ATPase subunit interface; other site 365046007722 PBP superfamily domain; Region: PBP_like_2; cl17296 365046007723 Fasciclin domain; Region: Fasciclin; pfam02469 365046007724 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 365046007725 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 365046007726 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 365046007727 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 365046007728 amphipathic channel; other site 365046007729 Asn-Pro-Ala signature motifs; other site 365046007730 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 365046007731 Low molecular weight phosphatase family; Region: LMWPc; cd00115 365046007732 active site 365046007733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046007734 putative DNA binding site [nucleotide binding]; other site 365046007735 putative Zn2+ binding site [ion binding]; other site 365046007736 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046007737 catalytic core [active] 365046007738 polyphosphate kinase; Provisional; Region: PRK05443 365046007739 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 365046007740 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 365046007741 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 365046007742 putative domain interface [polypeptide binding]; other site 365046007743 putative active site [active] 365046007744 catalytic site [active] 365046007745 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 365046007746 putative active site [active] 365046007747 catalytic site [active] 365046007748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 365046007749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046007750 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 365046007751 putative active site [active] 365046007752 Zn binding site [ion binding]; other site 365046007753 isocitrate lyase; Provisional; Region: PRK15063 365046007754 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 365046007755 tetramer interface [polypeptide binding]; other site 365046007756 active site 365046007757 Mg2+/Mn2+ binding site [ion binding]; other site 365046007758 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 365046007759 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 365046007760 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 365046007761 putative DNA binding site [nucleotide binding]; other site 365046007762 putative Zn2+ binding site [ion binding]; other site 365046007763 AsnC family; Region: AsnC_trans_reg; pfam01037 365046007764 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 365046007765 SWIB/MDM2 domain; Region: SWIB; pfam02201 365046007766 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 365046007767 thiamine pyrophosphate protein; Validated; Region: PRK08199 365046007768 PYR/PP interface [polypeptide binding]; other site 365046007769 dimer interface [polypeptide binding]; other site 365046007770 TPP binding site [chemical binding]; other site 365046007771 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 365046007772 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 365046007773 TPP-binding site [chemical binding]; other site 365046007774 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 365046007775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046007776 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046007777 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 365046007778 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 365046007779 Protein of unknown function (DUF993); Region: DUF993; pfam06187 365046007780 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 365046007781 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 365046007782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 365046007783 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 365046007784 active site 365046007785 catalytic tetrad [active] 365046007786 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 365046007787 AAA ATPase domain; Region: AAA_16; pfam13191 365046007788 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 365046007789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046007790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046007791 putative substrate translocation pore; other site 365046007792 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 365046007793 nudix motif; other site 365046007794 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 365046007795 classical (c) SDRs; Region: SDR_c; cd05233 365046007796 NAD(P) binding site [chemical binding]; other site 365046007797 active site 365046007798 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 365046007799 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 365046007800 NADP binding site [chemical binding]; other site 365046007801 dimer interface [polypeptide binding]; other site 365046007802 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 365046007803 Clp amino terminal domain; Region: Clp_N; pfam02861 365046007804 Clp amino terminal domain; Region: Clp_N; pfam02861 365046007805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046007806 Walker A motif; other site 365046007807 ATP binding site [chemical binding]; other site 365046007808 Walker B motif; other site 365046007809 arginine finger; other site 365046007810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046007811 Walker A motif; other site 365046007812 ATP binding site [chemical binding]; other site 365046007813 Walker B motif; other site 365046007814 arginine finger; other site 365046007815 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 365046007816 hypothetical protein; Provisional; Region: PRK07538 365046007817 hypothetical protein; Provisional; Region: PRK07236 365046007818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046007819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 365046007820 MarR family; Region: MarR; pfam01047 365046007821 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046007822 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 365046007823 MoaE homodimer interface [polypeptide binding]; other site 365046007824 MoaD interaction [polypeptide binding]; other site 365046007825 active site residues [active] 365046007826 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 365046007827 MoaE interaction surface [polypeptide binding]; other site 365046007828 MoeB interaction surface [polypeptide binding]; other site 365046007829 thiocarboxylated glycine; other site 365046007830 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 365046007831 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 365046007832 dimer interface [polypeptide binding]; other site 365046007833 putative functional site; other site 365046007834 putative MPT binding site; other site 365046007835 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 365046007836 Walker A motif; other site 365046007837 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 365046007838 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 365046007839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046007840 catalytic residue [active] 365046007841 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 365046007842 oligomeric interface; other site 365046007843 putative active site [active] 365046007844 homodimer interface [polypeptide binding]; other site 365046007845 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 365046007846 homoserine dehydrogenase; Provisional; Region: PRK06349 365046007847 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 365046007848 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 365046007849 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 365046007850 aminotransferase AlaT; Validated; Region: PRK09265 365046007851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046007852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046007853 homodimer interface [polypeptide binding]; other site 365046007854 catalytic residue [active] 365046007855 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 365046007856 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 365046007857 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 365046007858 catalytic triad [active] 365046007859 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 365046007860 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 365046007861 putative active site [active] 365046007862 PhoH-like protein; Region: PhoH; pfam02562 365046007863 replicative DNA helicase; Region: DnaB; TIGR00665 365046007864 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 365046007865 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 365046007866 Walker A motif; other site 365046007867 ATP binding site [chemical binding]; other site 365046007868 Walker B motif; other site 365046007869 DNA binding loops [nucleotide binding] 365046007870 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 365046007871 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 365046007872 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 365046007873 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 365046007874 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 365046007875 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 365046007876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046007877 putative substrate translocation pore; other site 365046007878 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 365046007879 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 365046007880 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 365046007881 phosphoenolpyruvate synthase; Validated; Region: PRK06464 365046007882 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 365046007883 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 365046007884 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 365046007885 PEP synthetase regulatory protein; Provisional; Region: PRK05339 365046007886 peroxiredoxin; Region: AhpC; TIGR03137 365046007887 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 365046007888 dimer interface [polypeptide binding]; other site 365046007889 decamer (pentamer of dimers) interface [polypeptide binding]; other site 365046007890 catalytic triad [active] 365046007891 peroxidatic and resolving cysteines [active] 365046007892 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 365046007893 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 365046007894 catalytic residue [active] 365046007895 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 365046007896 catalytic residues [active] 365046007897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046007898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046007899 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 365046007900 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 365046007901 heme binding site [chemical binding]; other site 365046007902 ferroxidase pore; other site 365046007903 ferroxidase diiron center [ion binding]; other site 365046007904 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 365046007905 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 365046007906 N-terminal plug; other site 365046007907 ligand-binding site [chemical binding]; other site 365046007908 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 365046007909 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 365046007910 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 365046007911 active site 365046007912 substrate binding site [chemical binding]; other site 365046007913 FMN binding site [chemical binding]; other site 365046007914 putative catalytic residues [active] 365046007915 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 365046007916 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 365046007917 N-terminal plug; other site 365046007918 ligand-binding site [chemical binding]; other site 365046007919 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 365046007920 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 365046007921 Imelysin; Region: Peptidase_M75; cl09159 365046007922 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 365046007923 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 365046007924 Imelysin; Region: Peptidase_M75; cl09159 365046007925 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 365046007926 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 365046007927 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 365046007928 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 365046007929 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 365046007930 TolR protein; Region: tolR; TIGR02801 365046007931 Hemin uptake protein hemP; Region: hemP; pfam10636 365046007932 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 365046007933 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 365046007934 YccA-like proteins; Region: YccA_like; cd10433 365046007935 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 365046007936 TRAM domain; Region: TRAM; pfam01938 365046007937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 365046007938 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046007939 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 365046007940 active site 365046007941 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 365046007942 active site 365046007943 catalytic site [active] 365046007944 substrate binding site [chemical binding]; other site 365046007945 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 365046007946 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 365046007947 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 365046007948 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 365046007949 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 365046007950 DNA binding residues [nucleotide binding] 365046007951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 365046007952 Peptidase family M23; Region: Peptidase_M23; pfam01551 365046007953 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 365046007954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046007955 S-adenosylmethionine binding site [chemical binding]; other site 365046007956 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 365046007957 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 365046007958 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 365046007959 NAD(P) binding site [chemical binding]; other site 365046007960 SurA N-terminal domain; Region: SurA_N_3; cl07813 365046007961 periplasmic folding chaperone; Provisional; Region: PRK10788 365046007962 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 365046007963 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 365046007964 IHF dimer interface [polypeptide binding]; other site 365046007965 IHF - DNA interface [nucleotide binding]; other site 365046007966 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 365046007967 tartrate dehydrogenase; Region: TTC; TIGR02089 365046007968 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 365046007969 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 365046007970 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 365046007971 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 365046007972 GIY-YIG motif/motif A; other site 365046007973 active site 365046007974 catalytic site [active] 365046007975 putative DNA binding site [nucleotide binding]; other site 365046007976 metal binding site [ion binding]; metal-binding site 365046007977 UvrB/uvrC motif; Region: UVR; pfam02151 365046007978 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 365046007979 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 365046007980 elongation factor P; Validated; Region: PRK00529 365046007981 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 365046007982 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 365046007983 RNA binding site [nucleotide binding]; other site 365046007984 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 365046007985 RNA binding site [nucleotide binding]; other site 365046007986 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 365046007987 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 365046007988 RmuC family; Region: RmuC; pfam02646 365046007989 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 365046007990 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 365046007991 dimerization interface [polypeptide binding]; other site 365046007992 ligand binding site [chemical binding]; other site 365046007993 NADP binding site [chemical binding]; other site 365046007994 catalytic site [active] 365046007995 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 365046007996 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 365046007997 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 365046007998 putative FMN binding site [chemical binding]; other site 365046007999 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 365046008000 active site 365046008001 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 365046008002 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 365046008003 putative active site [active] 365046008004 Zn binding site [ion binding]; other site 365046008005 Phasin protein; Region: Phasin_2; pfam09361 365046008006 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 365046008007 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 365046008008 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 365046008009 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 365046008010 NAD binding site [chemical binding]; other site 365046008011 homodimer interface [polypeptide binding]; other site 365046008012 homotetramer interface [polypeptide binding]; other site 365046008013 active site 365046008014 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 365046008015 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 365046008016 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 365046008017 DNA primase, catalytic core; Region: dnaG; TIGR01391 365046008018 CHC2 zinc finger; Region: zf-CHC2; pfam01807 365046008019 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 365046008020 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 365046008021 active site 365046008022 metal binding site [ion binding]; metal-binding site 365046008023 interdomain interaction site; other site 365046008024 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 365046008025 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 365046008026 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 365046008027 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 365046008028 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 365046008029 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 365046008030 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 365046008031 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 365046008032 DNA binding residues [nucleotide binding] 365046008033 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 365046008034 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 365046008035 putative metal binding site [ion binding]; other site 365046008036 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 365046008037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 365046008038 active site 365046008039 catalytic tetrad [active] 365046008040 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 365046008041 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 365046008042 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 365046008043 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 365046008044 active site 365046008045 Fe(II) binding site [ion binding]; other site 365046008046 dimer interface [polypeptide binding]; other site 365046008047 tetramer interface [polypeptide binding]; other site 365046008048 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 365046008049 tetramer interface [polypeptide binding]; other site 365046008050 dimer interface [polypeptide binding]; other site 365046008051 active site 365046008052 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 365046008053 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 365046008054 active site 365046008055 hypothetical protein; Provisional; Region: PRK09262 365046008056 Amidohydrolase; Region: Amidohydro_2; pfam04909 365046008057 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 365046008058 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 365046008059 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 365046008060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046008061 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 365046008062 putative dimerization interface [polypeptide binding]; other site 365046008063 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 365046008064 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 365046008065 substrate binding site; other site 365046008066 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 365046008067 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 365046008068 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 365046008069 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 365046008070 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 365046008071 extended (e) SDRs; Region: SDR_e; cd08946 365046008072 NAD(P) binding site [chemical binding]; other site 365046008073 active site 365046008074 substrate binding site [chemical binding]; other site 365046008075 Core-2/I-Branching enzyme; Region: Branch; pfam02485 365046008076 Predicted permeases [General function prediction only]; Region: COG0679 365046008077 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 365046008078 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 365046008079 DctM-like transporters; Region: DctM; pfam06808 365046008080 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 365046008081 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 365046008082 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046008083 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046008084 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 365046008085 substrate binding site [chemical binding]; other site 365046008086 THF binding site; other site 365046008087 zinc-binding site [ion binding]; other site 365046008088 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046008089 GAF domain; Region: GAF; pfam01590 365046008090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008091 dimer interface [polypeptide binding]; other site 365046008092 phosphorylation site [posttranslational modification] 365046008093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008094 ATP binding site [chemical binding]; other site 365046008095 Mg2+ binding site [ion binding]; other site 365046008096 G-X-G motif; other site 365046008097 Response regulator receiver domain; Region: Response_reg; pfam00072 365046008098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008099 active site 365046008100 phosphorylation site [posttranslational modification] 365046008101 intermolecular recognition site; other site 365046008102 dimerization interface [polypeptide binding]; other site 365046008103 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 365046008104 putative binding surface; other site 365046008105 active site 365046008106 SpoVR family protein; Provisional; Region: PRK11767 365046008107 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 365046008108 hypothetical protein; Provisional; Region: PRK05325 365046008109 PrkA family serine protein kinase; Provisional; Region: PRK15455 365046008110 AAA ATPase domain; Region: AAA_16; pfam13191 365046008111 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 365046008112 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046008113 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046008114 putative active site [active] 365046008115 heme pocket [chemical binding]; other site 365046008116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008117 dimer interface [polypeptide binding]; other site 365046008118 phosphorylation site [posttranslational modification] 365046008119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008120 ATP binding site [chemical binding]; other site 365046008121 Mg2+ binding site [ion binding]; other site 365046008122 G-X-G motif; other site 365046008123 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 365046008124 active site 365046008125 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 365046008126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046008127 substrate binding site [chemical binding]; other site 365046008128 oxyanion hole (OAH) forming residues; other site 365046008129 trimer interface [polypeptide binding]; other site 365046008130 feruloyl-CoA synthase; Reviewed; Region: PRK08180 365046008131 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 365046008132 acyl-activating enzyme (AAE) consensus motif; other site 365046008133 putative AMP binding site [chemical binding]; other site 365046008134 putative active site [active] 365046008135 putative CoA binding site [chemical binding]; other site 365046008136 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046008137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 365046008138 MarR family; Region: MarR_2; pfam12802 365046008139 Predicted transcriptional regulators [Transcription]; Region: COG1733 365046008140 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 365046008141 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 365046008142 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 365046008143 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 365046008144 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 365046008145 GrpE; Region: GrpE; pfam01025 365046008146 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 365046008147 dimer interface [polypeptide binding]; other site 365046008148 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 365046008149 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 365046008150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 365046008151 nucleotide binding site [chemical binding]; other site 365046008152 chaperone protein DnaJ; Provisional; Region: PRK10767 365046008153 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 365046008154 HSP70 interaction site [polypeptide binding]; other site 365046008155 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 365046008156 substrate binding site [polypeptide binding]; other site 365046008157 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 365046008158 Zn binding sites [ion binding]; other site 365046008159 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 365046008160 dimer interface [polypeptide binding]; other site 365046008161 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 365046008162 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 365046008163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 365046008164 FeS/SAM binding site; other site 365046008165 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046008166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008167 active site 365046008168 phosphorylation site [posttranslational modification] 365046008169 intermolecular recognition site; other site 365046008170 dimerization interface [polypeptide binding]; other site 365046008171 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 365046008172 cyclase homology domain; Region: CHD; cd07302 365046008173 nucleotidyl binding site; other site 365046008174 metal binding site [ion binding]; metal-binding site 365046008175 dimer interface [polypeptide binding]; other site 365046008176 Predicted transcriptional regulators [Transcription]; Region: COG1510 365046008177 MarR family; Region: MarR_2; pfam12802 365046008178 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 365046008179 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 365046008180 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 365046008181 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 365046008182 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 365046008183 FMN binding site [chemical binding]; other site 365046008184 substrate binding site [chemical binding]; other site 365046008185 putative catalytic residue [active] 365046008186 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 365046008187 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 365046008188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046008189 active site 365046008190 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 365046008191 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 365046008192 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 365046008193 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 365046008194 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 365046008195 Ligand binding site [chemical binding]; other site 365046008196 Electron transfer flavoprotein domain; Region: ETF; pfam01012 365046008197 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 365046008198 Mechanosensitive ion channel; Region: MS_channel; pfam00924 365046008199 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 365046008200 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 365046008201 putative active site [active] 365046008202 Zn binding site [ion binding]; other site 365046008203 MoxR-like ATPases [General function prediction only]; Region: COG0714 365046008204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046008205 Walker A motif; other site 365046008206 ATP binding site [chemical binding]; other site 365046008207 Walker B motif; other site 365046008208 arginine finger; other site 365046008209 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 365046008210 Protein of unknown function DUF58; Region: DUF58; pfam01882 365046008211 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 365046008212 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 365046008213 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 365046008214 Transglycosylase SLT domain; Region: SLT_2; pfam13406 365046008215 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 365046008216 N-acetyl-D-glucosamine binding site [chemical binding]; other site 365046008217 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 365046008218 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 365046008219 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046008220 CoenzymeA binding site [chemical binding]; other site 365046008221 subunit interaction site [polypeptide binding]; other site 365046008222 PHB binding site; other site 365046008223 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 365046008224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 365046008225 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 365046008226 Uncharacterized conserved protein [Function unknown]; Region: COG2308 365046008227 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 365046008228 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 365046008229 Competence protein; Region: Competence; pfam03772 365046008230 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 365046008231 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 365046008232 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 365046008233 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 365046008234 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 365046008235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 365046008236 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 365046008237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046008238 putative active site [active] 365046008239 heme pocket [chemical binding]; other site 365046008240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008241 dimer interface [polypeptide binding]; other site 365046008242 phosphorylation site [posttranslational modification] 365046008243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008244 ATP binding site [chemical binding]; other site 365046008245 Mg2+ binding site [ion binding]; other site 365046008246 G-X-G motif; other site 365046008247 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 365046008248 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 365046008249 putative active site [active] 365046008250 catalytic site [active] 365046008251 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 365046008252 putative active site [active] 365046008253 catalytic site [active] 365046008254 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 365046008255 Surface antigen; Region: Bac_surface_Ag; pfam01103 365046008256 Family of unknown function (DUF490); Region: DUF490; pfam04357 365046008257 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046008258 GAF domain; Region: GAF; pfam01590 365046008259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046008260 PAS fold; Region: PAS_3; pfam08447 365046008261 putative active site [active] 365046008262 heme pocket [chemical binding]; other site 365046008263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046008264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008265 dimer interface [polypeptide binding]; other site 365046008266 phosphorylation site [posttranslational modification] 365046008267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008268 ATP binding site [chemical binding]; other site 365046008269 Mg2+ binding site [ion binding]; other site 365046008270 G-X-G motif; other site 365046008271 Response regulator receiver domain; Region: Response_reg; pfam00072 365046008272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008273 active site 365046008274 phosphorylation site [posttranslational modification] 365046008275 intermolecular recognition site; other site 365046008276 dimerization interface [polypeptide binding]; other site 365046008277 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 365046008278 heme binding pocket [chemical binding]; other site 365046008279 heme ligand [chemical binding]; other site 365046008280 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 365046008281 GAF domain; Region: GAF; pfam01590 365046008282 Phytochrome region; Region: PHY; pfam00360 365046008283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008284 dimer interface [polypeptide binding]; other site 365046008285 phosphorylation site [posttranslational modification] 365046008286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008287 ATP binding site [chemical binding]; other site 365046008288 Mg2+ binding site [ion binding]; other site 365046008289 G-X-G motif; other site 365046008290 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046008291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008292 active site 365046008293 phosphorylation site [posttranslational modification] 365046008294 intermolecular recognition site; other site 365046008295 dimerization interface [polypeptide binding]; other site 365046008296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008297 active site 365046008298 phosphorylation site [posttranslational modification] 365046008299 intermolecular recognition site; other site 365046008300 dimerization interface [polypeptide binding]; other site 365046008301 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046008302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046008303 putative active site [active] 365046008304 heme pocket [chemical binding]; other site 365046008305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008306 dimer interface [polypeptide binding]; other site 365046008307 phosphorylation site [posttranslational modification] 365046008308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008309 ATP binding site [chemical binding]; other site 365046008310 Mg2+ binding site [ion binding]; other site 365046008311 G-X-G motif; other site 365046008312 Response regulator receiver domain; Region: Response_reg; pfam00072 365046008313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008314 active site 365046008315 phosphorylation site [posttranslational modification] 365046008316 intermolecular recognition site; other site 365046008317 dimerization interface [polypeptide binding]; other site 365046008318 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 365046008319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 365046008320 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 365046008321 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 365046008322 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 365046008323 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 365046008324 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 365046008325 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 365046008326 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 365046008327 homotrimer interaction site [polypeptide binding]; other site 365046008328 putative active site [active] 365046008329 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 365046008330 Methyltransferase domain; Region: Methyltransf_18; pfam12847 365046008331 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 365046008332 YCII-related domain; Region: YCII; cl00999 365046008333 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 365046008334 potential frameshift: common BLAST hit: gi|121605999|ref|YP_983328.1| transposase IS116/IS110/IS902 family protein 365046008335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 365046008336 Transposase; Region: DEDD_Tnp_IS110; pfam01548 365046008337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 365046008338 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 365046008339 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 365046008340 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 365046008341 CAP-like domain; other site 365046008342 active site 365046008343 primary dimer interface [polypeptide binding]; other site 365046008344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 365046008345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 365046008346 metal binding site [ion binding]; metal-binding site 365046008347 active site 365046008348 I-site; other site 365046008349 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 365046008350 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 365046008351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008352 ATP binding site [chemical binding]; other site 365046008353 Mg2+ binding site [ion binding]; other site 365046008354 G-X-G motif; other site 365046008355 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 365046008356 anchoring element; other site 365046008357 dimer interface [polypeptide binding]; other site 365046008358 ATP binding site [chemical binding]; other site 365046008359 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 365046008360 active site 365046008361 metal binding site [ion binding]; metal-binding site 365046008362 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 365046008363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046008364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046008365 putative substrate translocation pore; other site 365046008366 short chain dehydrogenase; Provisional; Region: PRK06181 365046008367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046008368 NAD(P) binding site [chemical binding]; other site 365046008369 active site 365046008370 Methyltransferase domain; Region: Methyltransf_23; pfam13489 365046008371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046008372 S-adenosylmethionine binding site [chemical binding]; other site 365046008373 dihydrodipicolinate synthase; Region: dapA; TIGR00674 365046008374 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 365046008375 dimer interface [polypeptide binding]; other site 365046008376 active site 365046008377 catalytic residue [active] 365046008378 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 365046008379 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 365046008380 Uncharacterized conserved protein [Function unknown]; Region: COG2850 365046008381 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 365046008382 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 365046008383 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 365046008384 trimer interface [polypeptide binding]; other site 365046008385 active site 365046008386 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 365046008387 Flavoprotein; Region: Flavoprotein; pfam02441 365046008388 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 365046008389 CTP synthetase; Validated; Region: pyrG; PRK05380 365046008390 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 365046008391 active site 365046008392 UTP binding site [chemical binding]; other site 365046008393 Catalytic site [active] 365046008394 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 365046008395 active site 365046008396 putative oxyanion hole; other site 365046008397 catalytic triad [active] 365046008398 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 365046008399 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 365046008400 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 365046008401 enolase; Provisional; Region: eno; PRK00077 365046008402 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 365046008403 dimer interface [polypeptide binding]; other site 365046008404 metal binding site [ion binding]; metal-binding site 365046008405 substrate binding pocket [chemical binding]; other site 365046008406 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 365046008407 Septum formation initiator; Region: DivIC; cl17659 365046008408 AAA domain; Region: AAA_28; pfam13521 365046008409 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 365046008410 Response regulator receiver domain; Region: Response_reg; pfam00072 365046008411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008412 active site 365046008413 phosphorylation site [posttranslational modification] 365046008414 intermolecular recognition site; other site 365046008415 dimerization interface [polypeptide binding]; other site 365046008416 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 365046008417 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 365046008418 dimerization interface [polypeptide binding]; other site 365046008419 domain crossover interface; other site 365046008420 redox-dependent activation switch; other site 365046008421 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 365046008422 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 365046008423 trimer interface [polypeptide binding]; other site 365046008424 putative metal binding site [ion binding]; other site 365046008425 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 365046008426 dinuclear metal binding motif [ion binding]; other site 365046008427 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 365046008428 Ligand Binding Site [chemical binding]; other site 365046008429 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 365046008430 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 365046008431 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 365046008432 active site 365046008433 Int/Topo IB signature motif; other site 365046008434 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046008435 Membrane transport protein; Region: Mem_trans; cl09117 365046008436 epoxyqueuosine reductase; Region: TIGR00276 365046008437 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 365046008438 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 365046008439 AMIN domain; Region: AMIN; pfam11741 365046008440 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 365046008441 active site 365046008442 metal binding site [ion binding]; metal-binding site 365046008443 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 365046008444 inter-subunit interface; other site 365046008445 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 365046008446 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 365046008447 iron-sulfur cluster [ion binding]; other site 365046008448 [2Fe-2S] cluster binding site [ion binding]; other site 365046008449 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 365046008450 putative alpha subunit interface [polypeptide binding]; other site 365046008451 putative active site [active] 365046008452 putative substrate binding site [chemical binding]; other site 365046008453 Fe binding site [ion binding]; other site 365046008454 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 365046008455 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 365046008456 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 365046008457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008458 ATP binding site [chemical binding]; other site 365046008459 Mg2+ binding site [ion binding]; other site 365046008460 G-X-G motif; other site 365046008461 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 365046008462 ATP binding site [chemical binding]; other site 365046008463 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 365046008464 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046008465 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 365046008466 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 365046008467 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 365046008468 Cupin domain; Region: Cupin_2; pfam07883 365046008469 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 365046008470 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 365046008471 Sensors of blue-light using FAD; Region: BLUF; cl04855 365046008472 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 365046008473 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 365046008474 Walker A/P-loop; other site 365046008475 ATP binding site [chemical binding]; other site 365046008476 Q-loop/lid; other site 365046008477 ABC transporter signature motif; other site 365046008478 Walker B; other site 365046008479 D-loop; other site 365046008480 H-loop/switch region; other site 365046008481 Hemerythrin-like domain; Region: Hr-like; cd12108 365046008482 Fe binding site [ion binding]; other site 365046008483 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 365046008484 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 365046008485 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 365046008486 FtsX-like permease family; Region: FtsX; pfam02687 365046008487 HipA N-terminal domain; Region: Couple_hipA; pfam13657 365046008488 HipA-like N-terminal domain; Region: HipA_N; pfam07805 365046008489 HipA-like C-terminal domain; Region: HipA_C; pfam07804 365046008490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046008491 non-specific DNA binding site [nucleotide binding]; other site 365046008492 salt bridge; other site 365046008493 sequence-specific DNA binding site [nucleotide binding]; other site 365046008494 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 365046008495 Predicted membrane protein [Function unknown]; Region: COG2860 365046008496 UPF0126 domain; Region: UPF0126; pfam03458 365046008497 UPF0126 domain; Region: UPF0126; pfam03458 365046008498 PAS fold; Region: PAS_4; pfam08448 365046008499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046008500 putative active site [active] 365046008501 heme pocket [chemical binding]; other site 365046008502 PAS fold; Region: PAS_3; pfam08447 365046008503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046008504 PAS fold; Region: PAS_3; pfam08447 365046008505 putative active site [active] 365046008506 heme pocket [chemical binding]; other site 365046008507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046008508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008509 dimer interface [polypeptide binding]; other site 365046008510 phosphorylation site [posttranslational modification] 365046008511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008512 Mg2+ binding site [ion binding]; other site 365046008513 G-X-G motif; other site 365046008514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008515 Response regulator receiver domain; Region: Response_reg; pfam00072 365046008516 active site 365046008517 phosphorylation site [posttranslational modification] 365046008518 intermolecular recognition site; other site 365046008519 dimerization interface [polypeptide binding]; other site 365046008520 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 365046008521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046008522 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 365046008523 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 365046008524 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 365046008525 putative active site [active] 365046008526 putative metal binding site [ion binding]; other site 365046008527 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 365046008528 Phosphotransferase enzyme family; Region: APH; pfam01636 365046008529 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 365046008530 active site 365046008531 ATP binding site [chemical binding]; other site 365046008532 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 365046008533 substrate binding site [chemical binding]; other site 365046008534 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 365046008535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046008536 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 365046008537 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 365046008538 Multicopper oxidase; Region: Cu-oxidase; pfam00394 365046008539 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 365046008540 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 365046008541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 365046008542 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 365046008543 Walker A/P-loop; other site 365046008544 ATP binding site [chemical binding]; other site 365046008545 Q-loop/lid; other site 365046008546 ABC transporter signature motif; other site 365046008547 Walker B; other site 365046008548 D-loop; other site 365046008549 H-loop/switch region; other site 365046008550 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 365046008551 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 365046008552 dimer interface [polypeptide binding]; other site 365046008553 ADP-ribose binding site [chemical binding]; other site 365046008554 active site 365046008555 nudix motif; other site 365046008556 metal binding site [ion binding]; metal-binding site 365046008557 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 365046008558 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144 365046008559 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 365046008560 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 365046008561 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 365046008562 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 365046008563 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 365046008564 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 365046008565 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 365046008566 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 365046008567 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 365046008568 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 365046008569 4Fe-4S binding domain; Region: Fer4; pfam00037 365046008570 4Fe-4S binding domain; Region: Fer4; pfam00037 365046008571 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 365046008572 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 365046008573 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046008574 catalytic loop [active] 365046008575 iron binding site [ion binding]; other site 365046008576 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 365046008577 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 365046008578 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 365046008579 SLBB domain; Region: SLBB; pfam10531 365046008580 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 365046008581 NADH dehydrogenase subunit E; Validated; Region: PRK07539 365046008582 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 365046008583 putative dimer interface [polypeptide binding]; other site 365046008584 [2Fe-2S] cluster binding site [ion binding]; other site 365046008585 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 365046008586 NADH dehydrogenase subunit D; Validated; Region: PRK06075 365046008587 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 365046008588 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 365046008589 NADH dehydrogenase subunit B; Validated; Region: PRK06411 365046008590 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 365046008591 Preprotein translocase SecG subunit; Region: SecG; pfam03840 365046008592 triosephosphate isomerase; Provisional; Region: PRK14567 365046008593 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 365046008594 substrate binding site [chemical binding]; other site 365046008595 dimer interface [polypeptide binding]; other site 365046008596 catalytic triad [active] 365046008597 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 365046008598 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 365046008599 NAD(P) binding site [chemical binding]; other site 365046008600 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 365046008601 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 365046008602 RNase E interface [polypeptide binding]; other site 365046008603 trimer interface [polypeptide binding]; other site 365046008604 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 365046008605 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 365046008606 RNase E interface [polypeptide binding]; other site 365046008607 trimer interface [polypeptide binding]; other site 365046008608 active site 365046008609 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 365046008610 putative nucleic acid binding region [nucleotide binding]; other site 365046008611 G-X-X-G motif; other site 365046008612 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 365046008613 RNA binding site [nucleotide binding]; other site 365046008614 domain interface; other site 365046008615 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 365046008616 16S/18S rRNA binding site [nucleotide binding]; other site 365046008617 S13e-L30e interaction site [polypeptide binding]; other site 365046008618 25S rRNA binding site [nucleotide binding]; other site 365046008619 aspartate aminotransferase; Provisional; Region: PRK06108 365046008620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046008621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046008622 homodimer interface [polypeptide binding]; other site 365046008623 catalytic residue [active] 365046008624 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 365046008625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046008626 putative DNA binding site [nucleotide binding]; other site 365046008627 putative Zn2+ binding site [ion binding]; other site 365046008628 AsnC family; Region: AsnC_trans_reg; pfam01037 365046008629 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 365046008630 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 365046008631 putative ligand binding site [chemical binding]; other site 365046008632 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 365046008633 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 365046008634 putative dimer interface [polypeptide binding]; other site 365046008635 UGMP family protein; Validated; Region: PRK09604 365046008636 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 365046008637 ANTAR domain; Region: ANTAR; pfam03861 365046008638 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 365046008639 NMT1-like family; Region: NMT1_2; pfam13379 365046008640 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 365046008641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046008642 dimer interface [polypeptide binding]; other site 365046008643 conserved gate region; other site 365046008644 putative PBP binding loops; other site 365046008645 ABC-ATPase subunit interface; other site 365046008646 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 365046008647 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 365046008648 Walker A/P-loop; other site 365046008649 ATP binding site [chemical binding]; other site 365046008650 Q-loop/lid; other site 365046008651 ABC transporter signature motif; other site 365046008652 Walker B; other site 365046008653 D-loop; other site 365046008654 H-loop/switch region; other site 365046008655 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 365046008656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046008657 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 365046008658 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 365046008659 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 365046008660 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 365046008661 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 365046008662 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 365046008663 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 365046008664 [2Fe-2S] cluster binding site [ion binding]; other site 365046008665 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 365046008666 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 365046008667 [4Fe-4S] binding site [ion binding]; other site 365046008668 molybdopterin cofactor binding site; other site 365046008669 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 365046008670 molybdopterin cofactor binding site; other site 365046008671 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 365046008672 glycosyl transferase family protein; Provisional; Region: PRK08136 365046008673 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 365046008674 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 365046008675 active site 365046008676 SAM binding site [chemical binding]; other site 365046008677 homodimer interface [polypeptide binding]; other site 365046008678 HI0933-like protein; Region: HI0933_like; pfam03486 365046008679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046008680 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 365046008681 Yqey-like protein; Region: YqeY; pfam09424 365046008682 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 365046008683 peptidase PmbA; Provisional; Region: PRK11040 365046008684 Protein of unknown function (DUF615); Region: DUF615; pfam04751 365046008685 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 365046008686 MPT binding site; other site 365046008687 trimer interface [polypeptide binding]; other site 365046008688 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 365046008689 Amidase; Region: Amidase; cl11426 365046008690 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046008691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046008692 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 365046008693 putative effector binding pocket; other site 365046008694 dimerization interface [polypeptide binding]; other site 365046008695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046008696 NmrA-like family; Region: NmrA; pfam05368 365046008697 NAD(P) binding site [chemical binding]; other site 365046008698 active site 365046008699 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 365046008700 serine O-acetyltransferase; Region: cysE; TIGR01172 365046008701 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 365046008702 trimer interface [polypeptide binding]; other site 365046008703 active site 365046008704 substrate binding site [chemical binding]; other site 365046008705 CoA binding site [chemical binding]; other site 365046008706 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 365046008707 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 365046008708 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 365046008709 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 365046008710 active site 365046008711 dimerization interface [polypeptide binding]; other site 365046008712 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 365046008713 Mechanosensitive ion channel; Region: MS_channel; pfam00924 365046008714 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 365046008715 HPP family; Region: HPP; pfam04982 365046008716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 365046008717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008718 dimer interface [polypeptide binding]; other site 365046008719 phosphorylation site [posttranslational modification] 365046008720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008721 ATP binding site [chemical binding]; other site 365046008722 Mg2+ binding site [ion binding]; other site 365046008723 G-X-G motif; other site 365046008724 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 365046008725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008726 active site 365046008727 phosphorylation site [posttranslational modification] 365046008728 intermolecular recognition site; other site 365046008729 dimerization interface [polypeptide binding]; other site 365046008730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046008731 DNA binding site [nucleotide binding] 365046008732 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 365046008733 potassium uptake protein; Region: kup; TIGR00794 365046008734 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 365046008735 MutS domain I; Region: MutS_I; pfam01624 365046008736 MutS domain II; Region: MutS_II; pfam05188 365046008737 MutS domain III; Region: MutS_III; pfam05192 365046008738 MutS domain V; Region: MutS_V; pfam00488 365046008739 Walker A/P-loop; other site 365046008740 ATP binding site [chemical binding]; other site 365046008741 Q-loop/lid; other site 365046008742 ABC transporter signature motif; other site 365046008743 Walker B; other site 365046008744 D-loop; other site 365046008745 H-loop/switch region; other site 365046008746 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 365046008747 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 365046008748 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 365046008749 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 365046008750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046008751 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 365046008752 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 365046008753 Histidine kinase; Region: His_kinase; pfam06580 365046008754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008755 ATP binding site [chemical binding]; other site 365046008756 Mg2+ binding site [ion binding]; other site 365046008757 G-X-G motif; other site 365046008758 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 365046008759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008760 active site 365046008761 phosphorylation site [posttranslational modification] 365046008762 intermolecular recognition site; other site 365046008763 dimerization interface [polypeptide binding]; other site 365046008764 LytTr DNA-binding domain; Region: LytTR; smart00850 365046008765 thiamine pyrophosphate protein; Provisional; Region: PRK08273 365046008766 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 365046008767 PYR/PP interface [polypeptide binding]; other site 365046008768 dimer interface [polypeptide binding]; other site 365046008769 tetramer interface [polypeptide binding]; other site 365046008770 TPP binding site [chemical binding]; other site 365046008771 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 365046008772 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 365046008773 TPP-binding site [chemical binding]; other site 365046008774 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 365046008775 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 365046008776 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 365046008777 active site 365046008778 HIGH motif; other site 365046008779 nucleotide binding site [chemical binding]; other site 365046008780 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 365046008781 KMSKS motif; other site 365046008782 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 365046008783 GlpM protein; Region: GlpM; cl01212 365046008784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 365046008785 Methyltransferase domain; Region: Methyltransf_31; pfam13847 365046008786 S-adenosylmethionine binding site [chemical binding]; other site 365046008787 short chain dehydrogenase; Provisional; Region: PRK07109 365046008788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046008789 NAD(P) binding site [chemical binding]; other site 365046008790 active site 365046008791 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 365046008792 hypothetical protein; Provisional; Region: PRK09040 365046008793 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 365046008794 ligand binding site [chemical binding]; other site 365046008795 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 365046008796 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 365046008797 BON domain; Region: BON; pfam04972 365046008798 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 365046008799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046008800 S-adenosylmethionine binding site [chemical binding]; other site 365046008801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046008802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046008803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 365046008804 dimerization interface [polypeptide binding]; other site 365046008805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046008806 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 365046008807 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 365046008808 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 365046008809 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 365046008810 phosphate binding site [ion binding]; other site 365046008811 hypothetical protein; Validated; Region: PRK06201 365046008812 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 365046008813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046008814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046008815 dimer interface [polypeptide binding]; other site 365046008816 phosphorylation site [posttranslational modification] 365046008817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046008818 ATP binding site [chemical binding]; other site 365046008819 Mg2+ binding site [ion binding]; other site 365046008820 G-X-G motif; other site 365046008821 Response regulator receiver domain; Region: Response_reg; pfam00072 365046008822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046008823 active site 365046008824 phosphorylation site [posttranslational modification] 365046008825 intermolecular recognition site; other site 365046008826 dimerization interface [polypeptide binding]; other site 365046008827 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 365046008828 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 365046008829 ATP binding site [chemical binding]; other site 365046008830 Mg++ binding site [ion binding]; other site 365046008831 motif III; other site 365046008832 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046008833 nucleotide binding region [chemical binding]; other site 365046008834 ATP-binding site [chemical binding]; other site 365046008835 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 365046008836 putative RNA binding site [nucleotide binding]; other site 365046008837 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 365046008838 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 365046008839 active site 365046008840 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 365046008841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046008842 DNA-binding site [nucleotide binding]; DNA binding site 365046008843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046008844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046008845 homodimer interface [polypeptide binding]; other site 365046008846 catalytic residue [active] 365046008847 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 365046008848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046008849 dimer interface [polypeptide binding]; other site 365046008850 conserved gate region; other site 365046008851 putative PBP binding loops; other site 365046008852 ABC-ATPase subunit interface; other site 365046008853 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 365046008854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046008855 dimer interface [polypeptide binding]; other site 365046008856 conserved gate region; other site 365046008857 putative PBP binding loops; other site 365046008858 ABC-ATPase subunit interface; other site 365046008859 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 365046008860 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046008861 active site 365046008862 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046008863 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 365046008864 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 365046008865 Walker A/P-loop; other site 365046008866 ATP binding site [chemical binding]; other site 365046008867 Q-loop/lid; other site 365046008868 ABC transporter signature motif; other site 365046008869 Walker B; other site 365046008870 D-loop; other site 365046008871 H-loop/switch region; other site 365046008872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 365046008873 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 365046008874 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 365046008875 NMT1/THI5 like; Region: NMT1; pfam09084 365046008876 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 365046008877 histidinol dehydrogenase; Region: hisD; TIGR00069 365046008878 NAD binding site [chemical binding]; other site 365046008879 dimerization interface [polypeptide binding]; other site 365046008880 product binding site; other site 365046008881 substrate binding site [chemical binding]; other site 365046008882 zinc binding site [ion binding]; other site 365046008883 catalytic residues [active] 365046008884 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 365046008885 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046008886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046008887 catalytic residue [active] 365046008888 D-cysteine desulfhydrase; Validated; Region: PRK03910 365046008889 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 365046008890 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046008891 catalytic residue [active] 365046008892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046008893 NAD(P) binding site [chemical binding]; other site 365046008894 active site 365046008895 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 365046008896 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 365046008897 NAD(P) binding site [chemical binding]; other site 365046008898 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 365046008899 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 365046008900 NIPSNAP; Region: NIPSNAP; pfam07978 365046008901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046008902 dimerization interface [polypeptide binding]; other site 365046008903 putative DNA binding site [nucleotide binding]; other site 365046008904 putative Zn2+ binding site [ion binding]; other site 365046008905 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 365046008906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046008907 catalytic residue [active] 365046008908 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 365046008909 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 365046008910 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046008911 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 365046008912 dimer interface [polypeptide binding]; other site 365046008913 tellurium resistance terB-like protein; Region: terB_like; cl11965 365046008914 metal binding site [ion binding]; metal-binding site 365046008915 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 365046008916 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 365046008917 dimerization interface [polypeptide binding]; other site 365046008918 putative DNA binding site [nucleotide binding]; other site 365046008919 putative Zn2+ binding site [ion binding]; other site 365046008920 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 365046008921 active site 365046008922 NTP binding site [chemical binding]; other site 365046008923 metal binding triad [ion binding]; metal-binding site 365046008924 antibiotic binding site [chemical binding]; other site 365046008925 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 365046008926 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 365046008927 oxidoreductase; Provisional; Region: PRK06128 365046008928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046008929 NAD(P) binding site [chemical binding]; other site 365046008930 active site 365046008931 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 365046008932 Ion channel; Region: Ion_trans_2; pfam07885 365046008933 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 365046008934 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 365046008935 B3/4 domain; Region: B3_4; pfam03483 365046008936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046008937 S-adenosylmethionine binding site [chemical binding]; other site 365046008938 TspO/MBR family; Region: TspO_MBR; pfam03073 365046008939 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 365046008940 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 365046008941 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 365046008942 rRNA binding site [nucleotide binding]; other site 365046008943 predicted 30S ribosome binding site; other site 365046008944 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 365046008945 putative hydrolase; Provisional; Region: PRK11460 365046008946 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 365046008947 30S subunit binding site; other site 365046008948 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 365046008949 Protein of unknown function (DUF808); Region: DUF808; pfam05661 365046008950 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046008951 catalytic loop [active] 365046008952 iron binding site [ion binding]; other site 365046008953 Cytochrome c; Region: Cytochrom_C; cl11414 365046008954 Cytochrome c; Region: Cytochrom_C; cl11414 365046008955 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 365046008956 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 365046008957 Cytochrome c; Region: Cytochrom_C; pfam00034 365046008958 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 365046008959 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 365046008960 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 365046008961 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 365046008962 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 365046008963 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046008964 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 365046008965 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 365046008966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046008967 Walker A/P-loop; other site 365046008968 ATP binding site [chemical binding]; other site 365046008969 Q-loop/lid; other site 365046008970 ABC transporter signature motif; other site 365046008971 Walker B; other site 365046008972 D-loop; other site 365046008973 H-loop/switch region; other site 365046008974 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 365046008975 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046008976 putative ADP-binding pocket [chemical binding]; other site 365046008977 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 365046008978 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 365046008979 catalytic center binding site [active] 365046008980 ATP binding site [chemical binding]; other site 365046008981 poly(A) polymerase; Region: pcnB; TIGR01942 365046008982 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 365046008983 active site 365046008984 NTP binding site [chemical binding]; other site 365046008985 metal binding triad [ion binding]; metal-binding site 365046008986 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 365046008987 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 365046008988 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 365046008989 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 365046008990 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 365046008991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046008992 Walker A motif; other site 365046008993 ATP binding site [chemical binding]; other site 365046008994 Walker B motif; other site 365046008995 arginine finger; other site 365046008996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 365046008997 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 365046008998 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 365046008999 dimerization interface [polypeptide binding]; other site 365046009000 putative ATP binding site [chemical binding]; other site 365046009001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 365046009002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 365046009003 P-loop; other site 365046009004 Magnesium ion binding site [ion binding]; other site 365046009005 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 365046009006 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 365046009007 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 365046009008 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 365046009009 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 365046009010 acetylornithine aminotransferase; Provisional; Region: PRK02627 365046009011 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 365046009012 inhibitor-cofactor binding pocket; inhibition site 365046009013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046009014 catalytic residue [active] 365046009015 ornithine carbamoyltransferase; Provisional; Region: PRK00779 365046009016 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 365046009017 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 365046009018 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 365046009019 Putative cyclase; Region: Cyclase; cl00814 365046009020 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 365046009021 kynureninase; Region: kynureninase; TIGR01814 365046009022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046009023 catalytic residue [active] 365046009024 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 365046009025 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 365046009026 active site 365046009027 nucleophile elbow; other site 365046009028 salicylate hydroxylase; Provisional; Region: PRK08163 365046009029 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 365046009030 aconitate hydratase; Validated; Region: PRK09277 365046009031 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 365046009032 substrate binding site [chemical binding]; other site 365046009033 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 365046009034 ligand binding site [chemical binding]; other site 365046009035 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 365046009036 substrate binding site [chemical binding]; other site 365046009037 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 365046009038 homodimer interface [polypeptide binding]; other site 365046009039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046009040 substrate-cofactor binding pocket; other site 365046009041 catalytic residue [active] 365046009042 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 365046009043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046009044 non-specific DNA binding site [nucleotide binding]; other site 365046009045 salt bridge; other site 365046009046 sequence-specific DNA binding site [nucleotide binding]; other site 365046009047 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 365046009048 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 365046009049 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 365046009050 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 365046009051 substrate binding site [chemical binding]; other site 365046009052 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 365046009053 substrate binding site [chemical binding]; other site 365046009054 ligand binding site [chemical binding]; other site 365046009055 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 365046009056 malate dehydrogenase; Provisional; Region: PRK05442 365046009057 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 365046009058 NAD(P) binding site [chemical binding]; other site 365046009059 dimer interface [polypeptide binding]; other site 365046009060 malate binding site [chemical binding]; other site 365046009061 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 365046009062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 365046009063 DNA-binding site [nucleotide binding]; DNA binding site 365046009064 UTRA domain; Region: UTRA; pfam07702 365046009065 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 365046009066 Iron-sulfur protein interface; other site 365046009067 proximal quinone binding site [chemical binding]; other site 365046009068 SdhD (CybS) interface [polypeptide binding]; other site 365046009069 proximal heme binding site [chemical binding]; other site 365046009070 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 365046009071 SdhC subunit interface [polypeptide binding]; other site 365046009072 proximal heme binding site [chemical binding]; other site 365046009073 cardiolipin binding site; other site 365046009074 Iron-sulfur protein interface; other site 365046009075 proximal quinone binding site [chemical binding]; other site 365046009076 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 365046009077 L-aspartate oxidase; Provisional; Region: PRK06175 365046009078 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 365046009079 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 365046009080 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 365046009081 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 365046009082 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 365046009083 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 365046009084 dimer interface [polypeptide binding]; other site 365046009085 active site 365046009086 citrylCoA binding site [chemical binding]; other site 365046009087 NADH binding [chemical binding]; other site 365046009088 cationic pore residues; other site 365046009089 oxalacetate/citrate binding site [chemical binding]; other site 365046009090 coenzyme A binding site [chemical binding]; other site 365046009091 catalytic triad [active] 365046009092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046009093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046009094 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 365046009095 putative dimerization interface [polypeptide binding]; other site 365046009096 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 365046009097 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 365046009098 substrate binding site [chemical binding]; other site 365046009099 ligand binding site [chemical binding]; other site 365046009100 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 365046009101 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 365046009102 substrate binding site [chemical binding]; other site 365046009103 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 365046009104 tartrate dehydrogenase; Region: TTC; TIGR02089 365046009105 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 365046009106 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 365046009107 FimV N-terminal domain; Region: FimV_core; TIGR03505 365046009108 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 365046009109 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 365046009110 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 365046009111 active site 365046009112 dimerization interface 3.5A [polypeptide binding]; other site 365046009113 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 365046009114 active site 365046009115 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 365046009116 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 365046009117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046009118 catalytic residue [active] 365046009119 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 365046009120 substrate binding site [chemical binding]; other site 365046009121 active site 365046009122 catalytic residues [active] 365046009123 heterodimer interface [polypeptide binding]; other site 365046009124 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 365046009125 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 365046009126 YGGT family; Region: YGGT; pfam02325 365046009127 YGGT family; Region: YGGT; pfam02325 365046009128 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 365046009129 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 365046009130 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 365046009131 NAD binding site [chemical binding]; other site 365046009132 homodimer interface [polypeptide binding]; other site 365046009133 active site 365046009134 substrate binding site [chemical binding]; other site 365046009135 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 365046009136 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046009137 putative ADP-binding pocket [chemical binding]; other site 365046009138 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 365046009139 Bacterial sugar transferase; Region: Bac_transf; pfam02397 365046009140 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 365046009141 putative CoA binding site [chemical binding]; other site 365046009142 putative trimer interface [polypeptide binding]; other site 365046009143 Methyltransferase domain; Region: Methyltransf_12; pfam08242 365046009144 Methyltransferase domain; Region: Methyltransf_23; pfam13489 365046009145 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 365046009146 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 365046009147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046009148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046009149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 365046009150 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 365046009151 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 365046009152 dimer interface [polypeptide binding]; other site 365046009153 putative anticodon binding site; other site 365046009154 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 365046009155 motif 1; other site 365046009156 active site 365046009157 motif 2; other site 365046009158 motif 3; other site 365046009159 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 365046009160 putative chaperone; Provisional; Region: PRK11678 365046009161 nucleotide binding site [chemical binding]; other site 365046009162 putative NEF/HSP70 interaction site [polypeptide binding]; other site 365046009163 SBD interface [polypeptide binding]; other site 365046009164 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 365046009165 beta-hexosaminidase; Provisional; Region: PRK05337 365046009166 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 365046009167 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 365046009168 active site 365046009169 hydrophilic channel; other site 365046009170 dimerization interface [polypeptide binding]; other site 365046009171 catalytic residues [active] 365046009172 active site lid [active] 365046009173 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 365046009174 Recombination protein O N terminal; Region: RecO_N; pfam11967 365046009175 GTPase Era; Reviewed; Region: era; PRK00089 365046009176 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 365046009177 G1 box; other site 365046009178 GTP/Mg2+ binding site [chemical binding]; other site 365046009179 Switch I region; other site 365046009180 G2 box; other site 365046009181 Switch II region; other site 365046009182 G3 box; other site 365046009183 G4 box; other site 365046009184 G5 box; other site 365046009185 KH domain; Region: KH_2; pfam07650 365046009186 G-X-X-G motif; other site 365046009187 ribonuclease III; Reviewed; Region: rnc; PRK00102 365046009188 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 365046009189 dimerization interface [polypeptide binding]; other site 365046009190 active site 365046009191 metal binding site [ion binding]; metal-binding site 365046009192 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 365046009193 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 365046009194 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 365046009195 Catalytic site [active] 365046009196 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 365046009197 GTP-binding protein LepA; Provisional; Region: PRK05433 365046009198 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 365046009199 G1 box; other site 365046009200 putative GEF interaction site [polypeptide binding]; other site 365046009201 GTP/Mg2+ binding site [chemical binding]; other site 365046009202 Switch I region; other site 365046009203 G2 box; other site 365046009204 G3 box; other site 365046009205 Switch II region; other site 365046009206 G4 box; other site 365046009207 G5 box; other site 365046009208 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 365046009209 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 365046009210 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 365046009211 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 365046009212 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 365046009213 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 365046009214 protein binding site [polypeptide binding]; other site 365046009215 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 365046009216 protein binding site [polypeptide binding]; other site 365046009217 anti-sigma E factor; Provisional; Region: rseB; PRK09455 365046009218 MucB/RseB family; Region: MucB_RseB; pfam03888 365046009219 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 365046009220 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 365046009221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 365046009222 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 365046009223 DNA binding residues [nucleotide binding] 365046009224 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 365046009225 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 365046009226 dimer interface [polypeptide binding]; other site 365046009227 active site 365046009228 acyl carrier protein; Provisional; Region: acpP; PRK00982 365046009229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 365046009230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046009231 NAD(P) binding site [chemical binding]; other site 365046009232 active site 365046009233 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 365046009234 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 365046009235 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 365046009236 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 365046009237 dimer interface [polypeptide binding]; other site 365046009238 active site 365046009239 CoA binding pocket [chemical binding]; other site 365046009240 putative phosphate acyltransferase; Provisional; Region: PRK05331 365046009241 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 365046009242 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 365046009243 Maf-like protein; Region: Maf; pfam02545 365046009244 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 365046009245 active site 365046009246 dimer interface [polypeptide binding]; other site 365046009247 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 365046009248 active site 365046009249 homodimer interface [polypeptide binding]; other site 365046009250 SAM binding site [chemical binding]; other site 365046009251 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 365046009252 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 365046009253 tandem repeat interface [polypeptide binding]; other site 365046009254 oligomer interface [polypeptide binding]; other site 365046009255 active site residues [active] 365046009256 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 365046009257 iron-sulfur cluster [ion binding]; other site 365046009258 [2Fe-2S] cluster binding site [ion binding]; other site 365046009259 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 365046009260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046009261 motif II; other site 365046009262 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 365046009263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 365046009264 RNA binding surface [nucleotide binding]; other site 365046009265 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 365046009266 active site 365046009267 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 365046009268 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 365046009269 homodimer interface [polypeptide binding]; other site 365046009270 oligonucleotide binding site [chemical binding]; other site 365046009271 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 365046009272 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 365046009273 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 365046009274 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 365046009275 active site 365046009276 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 365046009277 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 365046009278 domain interfaces; other site 365046009279 active site 365046009280 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 365046009281 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 365046009282 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046009283 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 365046009284 DNA binding residues [nucleotide binding] 365046009285 dimerization interface [polypeptide binding]; other site 365046009286 OpgC protein; Region: OpgC_C; pfam10129 365046009287 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 365046009288 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 365046009289 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 365046009290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009291 active site 365046009292 phosphorylation site [posttranslational modification] 365046009293 intermolecular recognition site; other site 365046009294 dimerization interface [polypeptide binding]; other site 365046009295 LytTr DNA-binding domain; Region: LytTR; smart00850 365046009296 Histidine kinase; Region: His_kinase; pfam06580 365046009297 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 365046009298 Mg2+ binding site [ion binding]; other site 365046009299 G-X-G motif; other site 365046009300 argininosuccinate lyase; Provisional; Region: PRK00855 365046009301 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 365046009302 active sites [active] 365046009303 tetramer interface [polypeptide binding]; other site 365046009304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 365046009305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 365046009306 active site 365046009307 phosphorylation site [posttranslational modification] 365046009308 intermolecular recognition site; other site 365046009309 dimerization interface [polypeptide binding]; other site 365046009310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046009311 DNA binding site [nucleotide binding] 365046009312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046009313 dimer interface [polypeptide binding]; other site 365046009314 phosphorylation site [posttranslational modification] 365046009315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046009316 ATP binding site [chemical binding]; other site 365046009317 Mg2+ binding site [ion binding]; other site 365046009318 G-X-G motif; other site 365046009319 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 365046009320 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 365046009321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 365046009322 protein binding site [polypeptide binding]; other site 365046009323 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 365046009324 protein binding site [polypeptide binding]; other site 365046009325 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 365046009326 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 365046009327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046009328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009329 active site 365046009330 phosphorylation site [posttranslational modification] 365046009331 intermolecular recognition site; other site 365046009332 dimerization interface [polypeptide binding]; other site 365046009333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046009334 DNA binding residues [nucleotide binding] 365046009335 dimerization interface [polypeptide binding]; other site 365046009336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046009337 PAS fold; Region: PAS_3; pfam08447 365046009338 putative active site [active] 365046009339 heme pocket [chemical binding]; other site 365046009340 PAS domain S-box; Region: sensory_box; TIGR00229 365046009341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046009342 putative active site [active] 365046009343 heme pocket [chemical binding]; other site 365046009344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046009345 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046009346 putative active site [active] 365046009347 heme pocket [chemical binding]; other site 365046009348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046009349 dimer interface [polypeptide binding]; other site 365046009350 phosphorylation site [posttranslational modification] 365046009351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046009352 ATP binding site [chemical binding]; other site 365046009353 Mg2+ binding site [ion binding]; other site 365046009354 G-X-G motif; other site 365046009355 Response regulator receiver domain; Region: Response_reg; pfam00072 365046009356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009357 active site 365046009358 phosphorylation site [posttranslational modification] 365046009359 intermolecular recognition site; other site 365046009360 dimerization interface [polypeptide binding]; other site 365046009361 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 365046009362 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 365046009363 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 365046009364 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 365046009365 phosphate binding site [ion binding]; other site 365046009366 CHASE3 domain; Region: CHASE3; pfam05227 365046009367 PAS fold; Region: PAS_3; pfam08447 365046009368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046009369 dimer interface [polypeptide binding]; other site 365046009370 phosphorylation site [posttranslational modification] 365046009371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046009372 ATP binding site [chemical binding]; other site 365046009373 Mg2+ binding site [ion binding]; other site 365046009374 G-X-G motif; other site 365046009375 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 365046009376 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 365046009377 active site 365046009378 DNA binding site [nucleotide binding] 365046009379 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 365046009380 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 365046009381 DNA binding residues [nucleotide binding] 365046009382 dimer interface [polypeptide binding]; other site 365046009383 copper binding site [ion binding]; other site 365046009384 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 365046009385 metal-binding site [ion binding] 365046009386 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 365046009387 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 365046009388 metal-binding site [ion binding] 365046009389 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 365046009390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046009391 motif II; other site 365046009392 Predicted metal-binding protein [General function prediction only]; Region: COG3019 365046009393 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 365046009394 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 365046009395 apolar tunnel; other site 365046009396 heme binding site [chemical binding]; other site 365046009397 dimerization interface [polypeptide binding]; other site 365046009398 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 365046009399 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 365046009400 GAF domain; Region: GAF; pfam01590 365046009401 Phytochrome region; Region: PHY; pfam00360 365046009402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046009403 dimer interface [polypeptide binding]; other site 365046009404 phosphorylation site [posttranslational modification] 365046009405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046009406 ATP binding site [chemical binding]; other site 365046009407 Mg2+ binding site [ion binding]; other site 365046009408 G-X-G motif; other site 365046009409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 365046009410 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 365046009411 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 365046009412 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 365046009413 hypothetical protein; Validated; Region: PRK02101 365046009414 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 365046009415 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 365046009416 tRNA; other site 365046009417 putative tRNA binding site [nucleotide binding]; other site 365046009418 putative NADP binding site [chemical binding]; other site 365046009419 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 365046009420 peptide chain release factor 1; Validated; Region: prfA; PRK00591 365046009421 This domain is found in peptide chain release factors; Region: PCRF; smart00937 365046009422 RF-1 domain; Region: RF-1; pfam00472 365046009423 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 365046009424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046009425 S-adenosylmethionine binding site [chemical binding]; other site 365046009426 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 365046009427 putative GSH binding site [chemical binding]; other site 365046009428 catalytic residues [active] 365046009429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046009430 Walker A motif; other site 365046009431 ATP binding site [chemical binding]; other site 365046009432 Walker B motif; other site 365046009433 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 365046009434 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 365046009435 N-acetyl-D-glucosamine binding site [chemical binding]; other site 365046009436 catalytic residue [active] 365046009437 prolyl-tRNA synthetase; Provisional; Region: PRK09194 365046009438 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 365046009439 dimer interface [polypeptide binding]; other site 365046009440 motif 1; other site 365046009441 active site 365046009442 motif 2; other site 365046009443 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 365046009444 putative deacylase active site [active] 365046009445 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 365046009446 active site 365046009447 motif 3; other site 365046009448 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 365046009449 anticodon binding site; other site 365046009450 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 365046009451 putative active site [active] 365046009452 Ap4A binding site [chemical binding]; other site 365046009453 nudix motif; other site 365046009454 putative metal binding site [ion binding]; other site 365046009455 CNP1-like family; Region: CNP1; pfam08750 365046009456 gamma-glutamyl kinase; Provisional; Region: PRK05429 365046009457 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 365046009458 nucleotide binding site [chemical binding]; other site 365046009459 homotetrameric interface [polypeptide binding]; other site 365046009460 putative phosphate binding site [ion binding]; other site 365046009461 putative allosteric binding site; other site 365046009462 PUA domain; Region: PUA; pfam01472 365046009463 GTPase CgtA; Reviewed; Region: obgE; PRK12299 365046009464 GTP1/OBG; Region: GTP1_OBG; pfam01018 365046009465 Obg GTPase; Region: Obg; cd01898 365046009466 G1 box; other site 365046009467 GTP/Mg2+ binding site [chemical binding]; other site 365046009468 Switch I region; other site 365046009469 G2 box; other site 365046009470 G3 box; other site 365046009471 Switch II region; other site 365046009472 G4 box; other site 365046009473 G5 box; other site 365046009474 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 365046009475 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 365046009476 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 365046009477 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 365046009478 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 365046009479 substrate binding pocket [chemical binding]; other site 365046009480 chain length determination region; other site 365046009481 substrate-Mg2+ binding site; other site 365046009482 catalytic residues [active] 365046009483 aspartate-rich region 1; other site 365046009484 active site lid residues [active] 365046009485 aspartate-rich region 2; other site 365046009486 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 365046009487 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 365046009488 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 365046009489 Walker A motif; other site 365046009490 ATP binding site [chemical binding]; other site 365046009491 Walker B motif; other site 365046009492 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 365046009493 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 365046009494 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 365046009495 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 365046009496 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 365046009497 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 365046009498 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 365046009499 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 365046009500 CoA-binding site [chemical binding]; other site 365046009501 ATP-binding [chemical binding]; other site 365046009502 hypothetical protein; Provisional; Region: PRK05287 365046009503 Domain of unknown function (DUF329); Region: DUF329; pfam03884 365046009504 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 365046009505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046009506 non-specific DNA binding site [nucleotide binding]; other site 365046009507 salt bridge; other site 365046009508 sequence-specific DNA binding site [nucleotide binding]; other site 365046009509 HipA N-terminal domain; Region: Couple_hipA; pfam13657 365046009510 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 365046009511 HipA-like N-terminal domain; Region: HipA_N; pfam07805 365046009512 HipA-like C-terminal domain; Region: HipA_C; pfam07804 365046009513 aspartate aminotransferase; Provisional; Region: PRK05764 365046009514 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 365046009515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046009516 homodimer interface [polypeptide binding]; other site 365046009517 catalytic residue [active] 365046009518 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 365046009519 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 365046009520 substrate binding site [chemical binding]; other site 365046009521 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 365046009522 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 365046009523 substrate binding site [chemical binding]; other site 365046009524 ligand binding site [chemical binding]; other site 365046009525 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046009526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046009527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046009528 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 365046009529 putative dimerization interface [polypeptide binding]; other site 365046009530 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 365046009531 Amidase; Region: Amidase; pfam01425 365046009532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046009533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046009534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 365046009535 dimerization interface [polypeptide binding]; other site 365046009536 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046009537 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 365046009538 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046009539 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 365046009540 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 365046009541 phosphate binding site [ion binding]; other site 365046009542 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 365046009543 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046009544 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046009545 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 365046009546 Family description; Region: VCBS; pfam13517 365046009547 PAS fold; Region: PAS_4; pfam08448 365046009548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046009549 putative active site [active] 365046009550 heme pocket [chemical binding]; other site 365046009551 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046009552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046009553 putative active site [active] 365046009554 heme pocket [chemical binding]; other site 365046009555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046009556 dimer interface [polypeptide binding]; other site 365046009557 phosphorylation site [posttranslational modification] 365046009558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046009559 ATP binding site [chemical binding]; other site 365046009560 Mg2+ binding site [ion binding]; other site 365046009561 G-X-G motif; other site 365046009562 Response regulator receiver domain; Region: Response_reg; pfam00072 365046009563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009564 active site 365046009565 phosphorylation site [posttranslational modification] 365046009566 intermolecular recognition site; other site 365046009567 dimerization interface [polypeptide binding]; other site 365046009568 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 365046009569 active site 365046009570 catalytic triad [active] 365046009571 oxyanion hole [active] 365046009572 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 365046009573 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 365046009574 DctM-like transporters; Region: DctM; pfam06808 365046009575 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 365046009576 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 365046009577 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 365046009578 alpha subunit interface [polypeptide binding]; other site 365046009579 TPP binding site [chemical binding]; other site 365046009580 heterodimer interface [polypeptide binding]; other site 365046009581 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 365046009582 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 365046009583 tetramer interface [polypeptide binding]; other site 365046009584 TPP-binding site [chemical binding]; other site 365046009585 heterodimer interface [polypeptide binding]; other site 365046009586 phosphorylation loop region [posttranslational modification] 365046009587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046009588 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 365046009589 Coenzyme A binding pocket [chemical binding]; other site 365046009590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 365046009591 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 365046009592 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 365046009593 conserved cys residue [active] 365046009594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046009595 RibD C-terminal domain; Region: RibD_C; cl17279 365046009596 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 365046009597 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 365046009598 conserved cys residue [active] 365046009599 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 365046009600 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 365046009601 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 365046009602 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 365046009603 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 365046009604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046009605 DNA binding site [nucleotide binding] 365046009606 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 365046009607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046009608 Helix-turn-helix domain; Region: HTH_18; pfam12833 365046009609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046009610 Tir chaperone protein (CesT) family; Region: CesT; cl08444 365046009611 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 365046009612 type III secretion system protein YscR; Provisional; Region: PRK12797 365046009613 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 365046009614 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 365046009615 Type III secretion protein (HpaP); Region: HpaP; cl17849 365046009616 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 365046009617 FHIPEP family; Region: FHIPEP; pfam00771 365046009618 type III secretion system protein HrcU; Validated; Region: PRK09108 365046009619 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 365046009620 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 365046009621 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 365046009622 N-acetyl-D-glucosamine binding site [chemical binding]; other site 365046009623 catalytic residue [active] 365046009624 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 365046009625 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 365046009626 N-acetyl-D-glucosamine binding site [chemical binding]; other site 365046009627 catalytic residue [active] 365046009628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 365046009629 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 365046009630 hypothetical protein; Provisional; Region: PRK11820 365046009631 type III secretion system ATPase; Provisional; Region: PRK09099 365046009632 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 365046009633 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 365046009634 Walker A motif; other site 365046009635 ATP binding site [chemical binding]; other site 365046009636 Walker B motif; other site 365046009637 type III secretion system protein HrpB; Validated; Region: PRK09098 365046009638 Flagellar assembly protein FliH; Region: FliH; pfam02108 365046009639 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 365046009640 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 365046009641 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 365046009642 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 365046009643 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 365046009644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046009645 S-adenosylmethionine binding site [chemical binding]; other site 365046009646 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 365046009647 NolX protein; Region: NolX; pfam05819 365046009648 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 365046009649 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 365046009650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046009651 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 365046009652 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 365046009653 dimer interface [polypeptide binding]; other site 365046009654 active site 365046009655 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 365046009656 dimer interface [polypeptide binding]; other site 365046009657 active site 365046009658 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 365046009659 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 365046009660 active site 365046009661 dimer interface [polypeptide binding]; other site 365046009662 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 365046009663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046009664 Walker A/P-loop; other site 365046009665 ATP binding site [chemical binding]; other site 365046009666 Q-loop/lid; other site 365046009667 ABC transporter signature motif; other site 365046009668 Walker B; other site 365046009669 D-loop; other site 365046009670 H-loop/switch region; other site 365046009671 TOBE domain; Region: TOBE_2; pfam08402 365046009672 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 365046009673 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 365046009674 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 365046009675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046009676 dimer interface [polypeptide binding]; other site 365046009677 conserved gate region; other site 365046009678 putative PBP binding loops; other site 365046009679 ABC-ATPase subunit interface; other site 365046009680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046009681 conserved gate region; other site 365046009682 dimer interface [polypeptide binding]; other site 365046009683 putative PBP binding loops; other site 365046009684 ABC-ATPase subunit interface; other site 365046009685 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 365046009686 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 365046009687 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 365046009688 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 365046009689 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 365046009690 active site 365046009691 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 365046009692 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 365046009693 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 365046009694 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 365046009695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046009696 salt bridge; other site 365046009697 non-specific DNA binding site [nucleotide binding]; other site 365046009698 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 365046009699 sequence-specific DNA binding site [nucleotide binding]; other site 365046009700 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 365046009701 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 365046009702 putative NAD(P) binding site [chemical binding]; other site 365046009703 Predicted transcriptional regulators [Transcription]; Region: COG1733 365046009704 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046009705 dimerization interface [polypeptide binding]; other site 365046009706 putative DNA binding site [nucleotide binding]; other site 365046009707 putative Zn2+ binding site [ion binding]; other site 365046009708 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046009709 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 365046009710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046009711 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 365046009712 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 365046009713 N-terminal plug; other site 365046009714 ligand-binding site [chemical binding]; other site 365046009715 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 365046009716 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 365046009717 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 365046009718 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 365046009719 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 365046009720 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 365046009721 Walker A/P-loop; other site 365046009722 ATP binding site [chemical binding]; other site 365046009723 Q-loop/lid; other site 365046009724 ABC transporter signature motif; other site 365046009725 Walker B; other site 365046009726 D-loop; other site 365046009727 H-loop/switch region; other site 365046009728 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 365046009729 putative DNA binding helix; other site 365046009730 metal binding site 2 [ion binding]; metal-binding site 365046009731 metal binding site 1 [ion binding]; metal-binding site 365046009732 structural Zn2+ binding site [ion binding]; other site 365046009733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046009734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046009735 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 365046009736 putative dimerization interface [polypeptide binding]; other site 365046009737 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 365046009738 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 365046009739 potential frameshift: common BLAST hit: gi|163857989|ref|YP_001632287.1| facyl-CoA transferase/carnitine dehydratase 365046009740 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046009741 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 365046009742 CoA-transferase family III; Region: CoA_transf_3; pfam02515 365046009743 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 365046009744 Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157 365046009745 homodimer interface [polypeptide binding]; other site 365046009746 ligand binding site [chemical binding]; other site 365046009747 NAD binding site [chemical binding]; other site 365046009748 catalytic site [active] 365046009749 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 365046009750 seryl-tRNA synthetase; Provisional; Region: PRK05431 365046009751 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 365046009752 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 365046009753 dimer interface [polypeptide binding]; other site 365046009754 active site 365046009755 motif 1; other site 365046009756 motif 2; other site 365046009757 motif 3; other site 365046009758 CsbD-like; Region: CsbD; pfam05532 365046009759 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 365046009760 threonine dehydratase; Provisional; Region: PRK08246 365046009761 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 365046009762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046009763 catalytic residue [active] 365046009764 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 365046009765 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 365046009766 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 365046009767 hypothetical protein; Reviewed; Region: PRK00024 365046009768 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 365046009769 MPN+ (JAMM) motif; other site 365046009770 Zinc-binding site [ion binding]; other site 365046009771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 365046009772 Smr domain; Region: Smr; pfam01713 365046009773 Peptidase family M48; Region: Peptidase_M48; cl12018 365046009774 LemA family; Region: LemA; cl00742 365046009775 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 365046009776 apolar tunnel; other site 365046009777 heme binding site [chemical binding]; other site 365046009778 dimerization interface [polypeptide binding]; other site 365046009779 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 365046009780 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 365046009781 FtsX-like permease family; Region: FtsX; pfam02687 365046009782 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 365046009783 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 365046009784 active site 365046009785 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 365046009786 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 365046009787 putative NADP binding site [chemical binding]; other site 365046009788 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 365046009789 active site 365046009790 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 365046009791 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 365046009792 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 365046009793 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 365046009794 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 365046009795 active site 365046009796 substrate binding site [chemical binding]; other site 365046009797 cosubstrate binding site; other site 365046009798 catalytic site [active] 365046009799 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 365046009800 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046009801 acyl-activating enzyme (AAE) consensus motif; other site 365046009802 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 365046009803 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 365046009804 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 365046009805 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 365046009806 AMP binding site [chemical binding]; other site 365046009807 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 365046009808 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 365046009809 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 365046009810 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 365046009811 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 365046009812 putative active site [active] 365046009813 putative metal binding site [ion binding]; other site 365046009814 Peptidase C13 family; Region: Peptidase_C13; cl02159 365046009815 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 365046009816 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 365046009817 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 365046009818 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 365046009819 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 365046009820 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 365046009821 [4Fe-4S] binding site [ion binding]; other site 365046009822 molybdopterin cofactor binding site; other site 365046009823 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 365046009824 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 365046009825 molybdopterin cofactor binding site; other site 365046009826 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 365046009827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009828 active site 365046009829 phosphorylation site [posttranslational modification] 365046009830 intermolecular recognition site; other site 365046009831 dimerization interface [polypeptide binding]; other site 365046009832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046009833 Walker A motif; other site 365046009834 ATP binding site [chemical binding]; other site 365046009835 Walker B motif; other site 365046009836 arginine finger; other site 365046009837 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 365046009838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046009839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046009840 dimerization interface [polypeptide binding]; other site 365046009841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046009842 dimer interface [polypeptide binding]; other site 365046009843 phosphorylation site [posttranslational modification] 365046009844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046009845 ATP binding site [chemical binding]; other site 365046009846 Mg2+ binding site [ion binding]; other site 365046009847 G-X-G motif; other site 365046009848 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 365046009849 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 365046009850 4Fe-4S binding domain; Region: Fer4; pfam00037 365046009851 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 365046009852 4Fe-4S binding domain; Region: Fer4; pfam00037 365046009853 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 365046009854 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 365046009855 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 365046009856 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 365046009857 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 365046009858 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046009859 catalytic loop [active] 365046009860 iron binding site [ion binding]; other site 365046009861 4Fe-4S binding domain; Region: Fer4; pfam00037 365046009862 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 365046009863 [4Fe-4S] binding site [ion binding]; other site 365046009864 molybdopterin cofactor binding site; other site 365046009865 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 365046009866 molybdopterin cofactor binding site; other site 365046009867 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 365046009868 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 365046009869 putative dimer interface [polypeptide binding]; other site 365046009870 [2Fe-2S] cluster binding site [ion binding]; other site 365046009871 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 365046009872 SLBB domain; Region: SLBB; pfam10531 365046009873 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 365046009874 Domain of unknown function DUF59; Region: DUF59; pfam01883 365046009875 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 365046009876 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 365046009877 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 365046009878 active site 365046009879 HIGH motif; other site 365046009880 KMSKS motif; other site 365046009881 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 365046009882 tRNA binding surface [nucleotide binding]; other site 365046009883 anticodon binding site; other site 365046009884 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 365046009885 dimer interface [polypeptide binding]; other site 365046009886 putative tRNA-binding site [nucleotide binding]; other site 365046009887 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 365046009888 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 365046009889 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 365046009890 L-aspartate oxidase; Provisional; Region: PRK09077 365046009891 L-aspartate oxidase; Provisional; Region: PRK06175 365046009892 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 365046009893 quinolinate synthetase; Provisional; Region: PRK09375 365046009894 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 365046009895 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 365046009896 dimerization interface [polypeptide binding]; other site 365046009897 active site 365046009898 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 365046009899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 365046009900 catalytic residues [active] 365046009901 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 365046009902 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 365046009903 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 365046009904 preprotein translocase subunit SecB; Validated; Region: PRK05751 365046009905 SecA binding site; other site 365046009906 Preprotein binding site; other site 365046009907 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 365046009908 GSH binding site [chemical binding]; other site 365046009909 catalytic residues [active] 365046009910 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 365046009911 active site residue [active] 365046009912 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046009913 catalytic core [active] 365046009914 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 365046009915 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 365046009916 C-terminal peptidase (prc); Region: prc; TIGR00225 365046009917 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 365046009918 protein binding site [polypeptide binding]; other site 365046009919 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 365046009920 Catalytic dyad [active] 365046009921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046009922 putative DNA binding site [nucleotide binding]; other site 365046009923 putative Zn2+ binding site [ion binding]; other site 365046009924 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 365046009925 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 365046009926 ATP binding site [chemical binding]; other site 365046009927 substrate interface [chemical binding]; other site 365046009928 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 365046009929 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 365046009930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009931 Response regulator receiver domain; Region: Response_reg; pfam00072 365046009932 active site 365046009933 phosphorylation site [posttranslational modification] 365046009934 intermolecular recognition site; other site 365046009935 dimerization interface [polypeptide binding]; other site 365046009936 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046009937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009938 active site 365046009939 phosphorylation site [posttranslational modification] 365046009940 intermolecular recognition site; other site 365046009941 dimerization interface [polypeptide binding]; other site 365046009942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046009943 DNA binding residues [nucleotide binding] 365046009944 dimerization interface [polypeptide binding]; other site 365046009945 CHASE3 domain; Region: CHASE3; pfam05227 365046009946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 365046009947 Histidine kinase; Region: HisKA_3; pfam07730 365046009948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046009949 ATP binding site [chemical binding]; other site 365046009950 Mg2+ binding site [ion binding]; other site 365046009951 G-X-G motif; other site 365046009952 BON domain; Region: BON; pfam04972 365046009953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 365046009954 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 365046009955 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 365046009956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046009957 ATP binding site [chemical binding]; other site 365046009958 putative Mg++ binding site [ion binding]; other site 365046009959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046009960 nucleotide binding region [chemical binding]; other site 365046009961 ATP-binding site [chemical binding]; other site 365046009962 DEAD/H associated; Region: DEAD_assoc; pfam08494 365046009963 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 365046009964 MarR family; Region: MarR_2; pfam12802 365046009965 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046009966 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046009967 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046009968 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 365046009969 Sulfatase; Region: Sulfatase; pfam00884 365046009970 Cupin; Region: Cupin_6; pfam12852 365046009971 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 365046009972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046009973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046009974 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 365046009975 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 365046009976 NADP binding site [chemical binding]; other site 365046009977 active site 365046009978 steroid binding site; other site 365046009979 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 365046009980 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 365046009981 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 365046009982 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046009983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009984 active site 365046009985 phosphorylation site [posttranslational modification] 365046009986 intermolecular recognition site; other site 365046009987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046009988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046009989 dimer interface [polypeptide binding]; other site 365046009990 phosphorylation site [posttranslational modification] 365046009991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046009992 ATP binding site [chemical binding]; other site 365046009993 Mg2+ binding site [ion binding]; other site 365046009994 G-X-G motif; other site 365046009995 Response regulator receiver domain; Region: Response_reg; pfam00072 365046009996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046009997 active site 365046009998 phosphorylation site [posttranslational modification] 365046009999 intermolecular recognition site; other site 365046010000 dimerization interface [polypeptide binding]; other site 365046010001 Response regulator receiver domain; Region: Response_reg; pfam00072 365046010002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046010003 active site 365046010004 phosphorylation site [posttranslational modification] 365046010005 intermolecular recognition site; other site 365046010006 dimerization interface [polypeptide binding]; other site 365046010007 CHASE3 domain; Region: CHASE3; pfam05227 365046010008 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 365046010009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046010010 putative active site [active] 365046010011 heme pocket [chemical binding]; other site 365046010012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046010013 dimer interface [polypeptide binding]; other site 365046010014 phosphorylation site [posttranslational modification] 365046010015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046010016 ATP binding site [chemical binding]; other site 365046010017 Mg2+ binding site [ion binding]; other site 365046010018 G-X-G motif; other site 365046010019 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 365046010020 Sensors of blue-light using FAD; Region: BLUF; pfam04940 365046010021 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 365046010022 active site 365046010023 ATP-dependent DNA ligase; Validated; Region: PRK09247 365046010024 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 365046010025 active site 365046010026 DNA binding site [nucleotide binding] 365046010027 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 365046010028 DNA binding site [nucleotide binding] 365046010029 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 365046010030 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 365046010031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 365046010032 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 365046010033 PLD-like domain; Region: PLDc_2; pfam13091 365046010034 putative active site [active] 365046010035 catalytic site [active] 365046010036 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 365046010037 PLD-like domain; Region: PLDc_2; pfam13091 365046010038 putative active site [active] 365046010039 catalytic site [active] 365046010040 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 365046010041 putative catalytic site [active] 365046010042 putative metal binding site [ion binding]; other site 365046010043 putative phosphate binding site [ion binding]; other site 365046010044 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 365046010045 nudix motif; other site 365046010046 CcdB protein; Region: CcdB; cl03380 365046010047 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 365046010048 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 365046010049 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 365046010050 dimer interface [polypeptide binding]; other site 365046010051 anticodon binding site; other site 365046010052 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 365046010053 homodimer interface [polypeptide binding]; other site 365046010054 motif 1; other site 365046010055 active site 365046010056 motif 2; other site 365046010057 GAD domain; Region: GAD; pfam02938 365046010058 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 365046010059 motif 3; other site 365046010060 Uncharacterized conserved protein [Function unknown]; Region: COG2928 365046010061 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 365046010062 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 365046010063 Na binding site [ion binding]; other site 365046010064 putative glycosylation site [posttranslational modification]; other site 365046010065 putative glycosylation site [posttranslational modification]; other site 365046010066 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 365046010067 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 365046010068 SCP-2 sterol transfer family; Region: SCP2; pfam02036 365046010069 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 365046010070 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 365046010071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046010072 S-adenosylmethionine binding site [chemical binding]; other site 365046010073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 365046010074 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 365046010075 HIT family signature motif; other site 365046010076 catalytic residue [active] 365046010077 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 365046010078 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 365046010079 FAD binding domain; Region: FAD_binding_4; pfam01565 365046010080 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 365046010081 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 365046010082 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 365046010083 Cysteine-rich domain; Region: CCG; pfam02754 365046010084 Cysteine-rich domain; Region: CCG; pfam02754 365046010085 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 365046010086 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 365046010087 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 365046010088 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 365046010089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046010090 dimer interface [polypeptide binding]; other site 365046010091 conserved gate region; other site 365046010092 putative PBP binding loops; other site 365046010093 ABC-ATPase subunit interface; other site 365046010094 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 365046010095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046010096 dimer interface [polypeptide binding]; other site 365046010097 conserved gate region; other site 365046010098 putative PBP binding loops; other site 365046010099 ABC-ATPase subunit interface; other site 365046010100 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 365046010101 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 365046010102 Walker A/P-loop; other site 365046010103 ATP binding site [chemical binding]; other site 365046010104 Q-loop/lid; other site 365046010105 ABC transporter signature motif; other site 365046010106 Walker B; other site 365046010107 D-loop; other site 365046010108 H-loop/switch region; other site 365046010109 TOBE domain; Region: TOBE_2; pfam08402 365046010110 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 365046010111 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 365046010112 putative active site [active] 365046010113 catalytic site [active] 365046010114 putative metal binding site [ion binding]; other site 365046010115 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 365046010116 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046010117 Zn binding site [ion binding]; other site 365046010118 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 365046010119 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 365046010120 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 365046010121 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 365046010122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 365046010123 active site 365046010124 HIGH motif; other site 365046010125 nucleotide binding site [chemical binding]; other site 365046010126 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 365046010127 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 365046010128 active site 365046010129 KMSKS motif; other site 365046010130 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 365046010131 tRNA binding surface [nucleotide binding]; other site 365046010132 anticodon binding site; other site 365046010133 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 365046010134 cystathionine beta-lyase; Provisional; Region: PRK07050 365046010135 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046010136 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046010137 catalytic residue [active] 365046010138 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 365046010139 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 365046010140 classical (c) SDRs; Region: SDR_c; cd05233 365046010141 NAD(P) binding site [chemical binding]; other site 365046010142 active site 365046010143 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 365046010144 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 365046010145 catalytic triad [active] 365046010146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046010147 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 365046010148 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 365046010149 catalytic site [active] 365046010150 Walker A/P-loop; other site 365046010151 G-X2-G-X-G-K; other site 365046010152 ATP binding site [chemical binding]; other site 365046010153 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 365046010154 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 365046010155 PYR/PP interface [polypeptide binding]; other site 365046010156 dimer interface [polypeptide binding]; other site 365046010157 TPP binding site [chemical binding]; other site 365046010158 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 365046010159 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 365046010160 TPP-binding site [chemical binding]; other site 365046010161 dimer interface [polypeptide binding]; other site 365046010162 Methyltransferase domain; Region: Methyltransf_23; pfam13489 365046010163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046010164 S-adenosylmethionine binding site [chemical binding]; other site 365046010165 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 365046010166 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 365046010167 NAD binding site [chemical binding]; other site 365046010168 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 365046010169 active site 365046010170 tetramer interface; other site 365046010171 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 365046010172 CPxP motif; other site 365046010173 Trm112p-like protein; Region: Trm112p; pfam03966 365046010174 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 365046010175 nudix motif; other site 365046010176 cysteine synthase B; Region: cysM; TIGR01138 365046010177 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 365046010178 dimer interface [polypeptide binding]; other site 365046010179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046010180 catalytic residue [active] 365046010181 H-NS histone family; Region: Histone_HNS; pfam00816 365046010182 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 365046010183 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 365046010184 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 365046010185 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 365046010186 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 365046010187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046010188 NAD(P) binding site [chemical binding]; other site 365046010189 active site 365046010190 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 365046010191 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 365046010192 catalytic loop [active] 365046010193 iron binding site [ion binding]; other site 365046010194 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 365046010195 FAD binding pocket [chemical binding]; other site 365046010196 FAD binding motif [chemical binding]; other site 365046010197 phosphate binding motif [ion binding]; other site 365046010198 beta-alpha-beta structure motif; other site 365046010199 NAD binding pocket [chemical binding]; other site 365046010200 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046010201 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 365046010202 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046010203 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046010204 Walker A/P-loop; other site 365046010205 ATP binding site [chemical binding]; other site 365046010206 Q-loop/lid; other site 365046010207 ABC transporter signature motif; other site 365046010208 Walker B; other site 365046010209 D-loop; other site 365046010210 H-loop/switch region; other site 365046010211 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046010212 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046010213 Walker A/P-loop; other site 365046010214 ATP binding site [chemical binding]; other site 365046010215 Q-loop/lid; other site 365046010216 ABC transporter signature motif; other site 365046010217 Walker B; other site 365046010218 D-loop; other site 365046010219 H-loop/switch region; other site 365046010220 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046010221 TM-ABC transporter signature motif; other site 365046010222 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046010223 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046010224 TM-ABC transporter signature motif; other site 365046010225 recombination factor protein RarA; Reviewed; Region: PRK13342 365046010226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046010227 Walker A motif; other site 365046010228 ATP binding site [chemical binding]; other site 365046010229 Walker B motif; other site 365046010230 arginine finger; other site 365046010231 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 365046010232 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 365046010233 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 365046010234 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 365046010235 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 365046010236 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 365046010237 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 365046010238 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 365046010239 ligand binding site [chemical binding]; other site 365046010240 flexible hinge region; other site 365046010241 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 365046010242 non-specific DNA interactions [nucleotide binding]; other site 365046010243 DNA binding site [nucleotide binding] 365046010244 sequence specific DNA binding site [nucleotide binding]; other site 365046010245 putative cAMP binding site [chemical binding]; other site 365046010246 thioredoxin reductase; Provisional; Region: PRK10262 365046010247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046010248 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 365046010249 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 365046010250 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 365046010251 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 365046010252 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 365046010253 Fatty acid desaturase; Region: FA_desaturase; pfam00487 365046010254 Di-iron ligands [ion binding]; other site 365046010255 Transposase; Region: DDE_Tnp_ISL3; pfam01610 365046010256 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 365046010257 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 365046010258 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 365046010259 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 365046010260 active site 365046010261 substrate binding site [chemical binding]; other site 365046010262 cosubstrate binding site; other site 365046010263 catalytic site [active] 365046010264 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 365046010265 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 365046010266 active site 365046010267 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 365046010268 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 365046010269 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 365046010270 active site 365046010271 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 365046010272 Lipase (class 2); Region: Lipase_2; pfam01674 365046010273 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 365046010274 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 365046010275 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 365046010276 active site 365046010277 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 365046010278 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 365046010279 active site 365046010280 Riboflavin kinase; Region: Flavokinase; smart00904 365046010281 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 365046010282 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 365046010283 active site 365046010284 HIGH motif; other site 365046010285 nucleotide binding site [chemical binding]; other site 365046010286 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 365046010287 active site 365046010288 KMSKS motif; other site 365046010289 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 365046010290 tRNA binding surface [nucleotide binding]; other site 365046010291 anticodon binding site; other site 365046010292 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 365046010293 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 365046010294 lipoprotein signal peptidase; Provisional; Region: PRK14787 365046010295 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 365046010296 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 365046010297 PhoU domain; Region: PhoU; pfam01895 365046010298 PhoU domain; Region: PhoU; pfam01895 365046010299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046010300 Response regulator receiver domain; Region: Response_reg; pfam00072 365046010301 active site 365046010302 phosphorylation site [posttranslational modification] 365046010303 intermolecular recognition site; other site 365046010304 dimerization interface [polypeptide binding]; other site 365046010305 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 365046010306 nudix motif; other site 365046010307 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 365046010308 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 365046010309 NADP binding site [chemical binding]; other site 365046010310 dimer interface [polypeptide binding]; other site 365046010311 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 365046010312 EamA-like transporter family; Region: EamA; pfam00892 365046010313 EamA-like transporter family; Region: EamA; pfam00892 365046010314 DinB family; Region: DinB; cl17821 365046010315 DinB superfamily; Region: DinB_2; pfam12867 365046010316 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 365046010317 short chain dehydrogenase; Provisional; Region: PRK08339 365046010318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046010319 NAD(P) binding site [chemical binding]; other site 365046010320 active site 365046010321 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 365046010322 EamA-like transporter family; Region: EamA; pfam00892 365046010323 EamA-like transporter family; Region: EamA; pfam00892 365046010324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 365046010325 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 365046010326 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 365046010327 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 365046010328 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 365046010329 Walker A motif; other site 365046010330 ATP binding site [chemical binding]; other site 365046010331 Walker B motif; other site 365046010332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 365046010333 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 365046010334 Beta-lactamase; Region: Beta-lactamase; pfam00144 365046010335 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 365046010336 active site 365046010337 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 365046010338 MoxR-like ATPases [General function prediction only]; Region: COG0714 365046010339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046010340 Walker A motif; other site 365046010341 ATP binding site [chemical binding]; other site 365046010342 Walker B motif; other site 365046010343 arginine finger; other site 365046010344 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 365046010345 Protein of unknown function DUF58; Region: DUF58; pfam01882 365046010346 von Willebrand factor type A domain; Region: VWA_2; pfam13519 365046010347 metal ion-dependent adhesion site (MIDAS); other site 365046010348 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046010349 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046010350 catalytic residue [active] 365046010351 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 365046010352 homotrimer interaction site [polypeptide binding]; other site 365046010353 putative active site [active] 365046010354 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 365046010355 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 365046010356 Walker A/P-loop; other site 365046010357 ATP binding site [chemical binding]; other site 365046010358 Q-loop/lid; other site 365046010359 ABC transporter signature motif; other site 365046010360 Walker B; other site 365046010361 D-loop; other site 365046010362 H-loop/switch region; other site 365046010363 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 365046010364 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 365046010365 FtsX-like permease family; Region: FtsX; pfam02687 365046010366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 365046010367 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 365046010368 DHH family; Region: DHH; pfam01368 365046010369 DHHA1 domain; Region: DHHA1; pfam02272 365046010370 ornithine cyclodeaminase; Validated; Region: PRK07340 365046010371 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 365046010372 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 365046010373 trimer interface [polypeptide binding]; other site 365046010374 active site 365046010375 RDD family; Region: RDD; pfam06271 365046010376 RDD family; Region: RDD; pfam06271 365046010377 Integral membrane protein DUF95; Region: DUF95; pfam01944 365046010378 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 365046010379 MoxR-like ATPases [General function prediction only]; Region: COG0714 365046010380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046010381 Walker A motif; other site 365046010382 ATP binding site [chemical binding]; other site 365046010383 Walker B motif; other site 365046010384 arginine finger; other site 365046010385 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 365046010386 Protein of unknown function DUF58; Region: DUF58; pfam01882 365046010387 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 365046010388 Protein of unknown function (DUF805); Region: DUF805; pfam05656 365046010389 guanine deaminase; Provisional; Region: PRK09228 365046010390 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046010391 active site 365046010392 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 365046010393 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 365046010394 putative ligand binding site [chemical binding]; other site 365046010395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 365046010396 binding surface 365046010397 TPR motif; other site 365046010398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 365046010399 Tetratricopeptide repeat; Region: TPR_12; pfam13424 365046010400 binding surface 365046010401 TPR motif; other site 365046010402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 365046010403 binding surface 365046010404 TPR motif; other site 365046010405 TPR repeat; Region: TPR_11; pfam13414 365046010406 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 365046010407 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 365046010408 active site 365046010409 purine riboside binding site [chemical binding]; other site 365046010410 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 365046010411 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 365046010412 active site 365046010413 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 365046010414 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046010415 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 365046010416 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 365046010417 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 365046010418 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 365046010419 Coenzyme A binding pocket [chemical binding]; other site 365046010420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046010421 salt bridge; other site 365046010422 non-specific DNA binding site [nucleotide binding]; other site 365046010423 sequence-specific DNA binding site [nucleotide binding]; other site 365046010424 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 365046010425 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 365046010426 putative ligand binding site [chemical binding]; other site 365046010427 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 365046010428 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 365046010429 TM-ABC transporter signature motif; other site 365046010430 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046010431 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 365046010432 TM-ABC transporter signature motif; other site 365046010433 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 365046010434 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 365046010435 Walker A/P-loop; other site 365046010436 ATP binding site [chemical binding]; other site 365046010437 Q-loop/lid; other site 365046010438 ABC transporter signature motif; other site 365046010439 Walker B; other site 365046010440 D-loop; other site 365046010441 H-loop/switch region; other site 365046010442 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 365046010443 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 365046010444 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 365046010445 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 365046010446 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 365046010447 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 365046010448 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 365046010449 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 365046010450 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 365046010451 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 365046010452 active site 365046010453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046010454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046010455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046010456 dimerization interface [polypeptide binding]; other site 365046010457 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 365046010458 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 365046010459 dimer interface [polypeptide binding]; other site 365046010460 PYR/PP interface [polypeptide binding]; other site 365046010461 TPP binding site [chemical binding]; other site 365046010462 substrate binding site [chemical binding]; other site 365046010463 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 365046010464 TPP-binding site [chemical binding]; other site 365046010465 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 365046010466 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 365046010467 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046010468 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 365046010469 active site 365046010470 BNR repeat-like domain; Region: BNR_2; pfam13088 365046010471 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 365046010472 DctM-like transporters; Region: DctM; pfam06808 365046010473 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 365046010474 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 365046010475 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 365046010476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046010477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046010478 dimerization interface [polypeptide binding]; other site 365046010479 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 365046010480 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 365046010481 MOFRL family; Region: MOFRL; pfam05161 365046010482 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 365046010483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046010484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 365046010485 dimerization interface [polypeptide binding]; other site 365046010486 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 365046010487 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046010488 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 365046010489 Protein of unknown function (DUF989); Region: DUF989; pfam06181 365046010490 Predicted membrane protein [Function unknown]; Region: COG3748 365046010491 Cytochrome c; Region: Cytochrom_C; pfam00034 365046010492 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 365046010493 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 365046010494 XdhC Rossmann domain; Region: XdhC_C; pfam13478 365046010495 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 365046010496 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 365046010497 active site 365046010498 homotetramer interface [polypeptide binding]; other site 365046010499 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 365046010500 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 365046010501 active site 365046010502 catalytic site [active] 365046010503 tetramer interface [polypeptide binding]; other site 365046010504 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590 365046010505 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 365046010506 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 365046010507 active site 365046010508 metal binding site [ion binding]; metal-binding site 365046010509 dimer interface [polypeptide binding]; other site 365046010510 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 365046010511 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 365046010512 putative metal binding site [ion binding]; other site 365046010513 Predicted membrane protein [Function unknown]; Region: COG2261 365046010514 NMT1/THI5 like; Region: NMT1; pfam09084 365046010515 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 365046010516 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 365046010517 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 365046010518 Walker A/P-loop; other site 365046010519 ATP binding site [chemical binding]; other site 365046010520 Q-loop/lid; other site 365046010521 ABC transporter signature motif; other site 365046010522 Walker B; other site 365046010523 D-loop; other site 365046010524 H-loop/switch region; other site 365046010525 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 365046010526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046010527 dimer interface [polypeptide binding]; other site 365046010528 conserved gate region; other site 365046010529 putative PBP binding loops; other site 365046010530 ABC-ATPase subunit interface; other site 365046010531 UreD urease accessory protein; Region: UreD; pfam01774 365046010532 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 365046010533 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046010534 Walker A/P-loop; other site 365046010535 ATP binding site [chemical binding]; other site 365046010536 Q-loop/lid; other site 365046010537 ABC transporter signature motif; other site 365046010538 Walker B; other site 365046010539 D-loop; other site 365046010540 H-loop/switch region; other site 365046010541 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 365046010542 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046010543 Walker A/P-loop; other site 365046010544 ATP binding site [chemical binding]; other site 365046010545 Q-loop/lid; other site 365046010546 ABC transporter signature motif; other site 365046010547 Walker B; other site 365046010548 D-loop; other site 365046010549 H-loop/switch region; other site 365046010550 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 365046010551 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 365046010552 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046010553 TM-ABC transporter signature motif; other site 365046010554 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046010555 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046010556 TM-ABC transporter signature motif; other site 365046010557 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 365046010558 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 365046010559 putative ligand binding site [chemical binding]; other site 365046010560 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 365046010561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 365046010562 putative homodimer interface [polypeptide binding]; other site 365046010563 AAA domain; Region: AAA_14; pfam13173 365046010564 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 365046010565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046010566 active site 365046010567 phosphorylation site [posttranslational modification] 365046010568 intermolecular recognition site; other site 365046010569 dimerization interface [polypeptide binding]; other site 365046010570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046010571 DNA binding residues [nucleotide binding] 365046010572 dimerization interface [polypeptide binding]; other site 365046010573 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 365046010574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046010575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046010576 dimer interface [polypeptide binding]; other site 365046010577 phosphorylation site [posttranslational modification] 365046010578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046010579 ATP binding site [chemical binding]; other site 365046010580 Mg2+ binding site [ion binding]; other site 365046010581 G-X-G motif; other site 365046010582 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 365046010583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046010584 active site 365046010585 phosphorylation site [posttranslational modification] 365046010586 intermolecular recognition site; other site 365046010587 dimerization interface [polypeptide binding]; other site 365046010588 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 365046010589 alpha-gamma subunit interface [polypeptide binding]; other site 365046010590 beta-gamma subunit interface [polypeptide binding]; other site 365046010591 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 365046010592 gamma-beta subunit interface [polypeptide binding]; other site 365046010593 alpha-beta subunit interface [polypeptide binding]; other site 365046010594 urease subunit alpha; Reviewed; Region: ureC; PRK13207 365046010595 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 365046010596 subunit interactions [polypeptide binding]; other site 365046010597 active site 365046010598 flap region; other site 365046010599 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 365046010600 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 365046010601 dimer interface [polypeptide binding]; other site 365046010602 catalytic residues [active] 365046010603 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 365046010604 UreF; Region: UreF; pfam01730 365046010605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 365046010606 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 365046010607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 365046010608 FeS/SAM binding site; other site 365046010609 HemN C-terminal domain; Region: HemN_C; pfam06969 365046010610 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 365046010611 active site 365046010612 dimerization interface [polypeptide binding]; other site 365046010613 ribonuclease PH; Reviewed; Region: rph; PRK00173 365046010614 Ribonuclease PH; Region: RNase_PH_bact; cd11362 365046010615 hexamer interface [polypeptide binding]; other site 365046010616 active site 365046010617 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 365046010618 Protein phosphatase 2C; Region: PP2C; pfam00481 365046010619 active site 365046010620 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 365046010621 Catalytic domain of Protein Kinases; Region: PKc; cd00180 365046010622 active site 365046010623 ATP binding site [chemical binding]; other site 365046010624 substrate binding site [chemical binding]; other site 365046010625 activation loop (A-loop); other site 365046010626 hypothetical protein; Provisional; Region: PRK11820 365046010627 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 365046010628 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 365046010629 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 365046010630 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 365046010631 catalytic site [active] 365046010632 G-X2-G-X-G-K; other site 365046010633 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 365046010634 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 365046010635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 365046010636 Zn2+ binding site [ion binding]; other site 365046010637 Mg2+ binding site [ion binding]; other site 365046010638 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 365046010639 synthetase active site [active] 365046010640 NTP binding site [chemical binding]; other site 365046010641 metal binding site [ion binding]; metal-binding site 365046010642 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 365046010643 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 365046010644 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 365046010645 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 365046010646 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 365046010647 PAS fold; Region: PAS_3; pfam08447 365046010648 PAS domain; Region: PAS_9; pfam13426 365046010649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046010650 putative active site [active] 365046010651 heme pocket [chemical binding]; other site 365046010652 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 365046010653 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 365046010654 metal binding site [ion binding]; metal-binding site 365046010655 active site 365046010656 I-site; other site 365046010657 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 365046010658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046010659 Response regulator receiver domain; Region: Response_reg; pfam00072 365046010660 active site 365046010661 phosphorylation site [posttranslational modification] 365046010662 intermolecular recognition site; other site 365046010663 dimerization interface [polypeptide binding]; other site 365046010664 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046010665 GAF domain; Region: GAF; pfam01590 365046010666 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 365046010667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 365046010668 metal binding site [ion binding]; metal-binding site 365046010669 active site 365046010670 I-site; other site 365046010671 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 365046010672 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 365046010673 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 365046010674 tetramer interface [polypeptide binding]; other site 365046010675 heme binding pocket [chemical binding]; other site 365046010676 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 365046010677 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 365046010678 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 365046010679 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 365046010680 catalytic residue [active] 365046010681 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 365046010682 active site 365046010683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 365046010684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046010685 DNA binding residues [nucleotide binding] 365046010686 dimerization interface [polypeptide binding]; other site 365046010687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 365046010688 non-specific DNA binding site [nucleotide binding]; other site 365046010689 salt bridge; other site 365046010690 sequence-specific DNA binding site [nucleotide binding]; other site 365046010691 AAA domain; Region: AAA_21; pfam13304 365046010692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046010693 ABC transporter signature motif; other site 365046010694 Walker B; other site 365046010695 D-loop; other site 365046010696 H-loop/switch region; other site 365046010697 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 365046010698 DNA binding site [nucleotide binding] 365046010699 active site 365046010700 Int/Topo IB signature motif; other site 365046010701 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 365046010702 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 365046010703 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 365046010704 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 365046010705 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 365046010706 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 365046010707 Walker A/P-loop; other site 365046010708 ATP binding site [chemical binding]; other site 365046010709 Q-loop/lid; other site 365046010710 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 365046010711 ABC transporter signature motif; other site 365046010712 Walker B; other site 365046010713 D-loop; other site 365046010714 H-loop/switch region; other site 365046010715 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 365046010716 AAA domain; Region: AAA_18; pfam13238 365046010717 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 365046010718 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 365046010719 minor groove reading motif; other site 365046010720 helix-hairpin-helix signature motif; other site 365046010721 substrate binding pocket [chemical binding]; other site 365046010722 active site 365046010723 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 365046010724 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 365046010725 DNA binding and oxoG recognition site [nucleotide binding] 365046010726 Dynamin family; Region: Dynamin_N; pfam00350 365046010727 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 365046010728 G1 box; other site 365046010729 GTP/Mg2+ binding site [chemical binding]; other site 365046010730 G2 box; other site 365046010731 Switch I region; other site 365046010732 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 365046010733 G3 box; other site 365046010734 Switch II region; other site 365046010735 GTP/Mg2+ binding site [chemical binding]; other site 365046010736 G4 box; other site 365046010737 G5 box; other site 365046010738 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 365046010739 Formamidopyrimidine-DNA glycosylase N-terminal domain; Region: Fapy_DNA_glyco; smart00898 365046010740 DNA binding site [nucleotide binding] 365046010741 catalytic residue [active] 365046010742 H2TH interface [polypeptide binding]; other site 365046010743 putative catalytic residues [active] 365046010744 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 365046010745 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 365046010746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 365046010747 binding surface 365046010748 TPR motif; other site 365046010749 TPR repeat; Region: TPR_11; pfam13414 365046010750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 365046010751 binding surface 365046010752 TPR motif; other site 365046010753 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 365046010754 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 365046010755 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 365046010756 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 365046010757 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 365046010758 active site 365046010759 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 365046010760 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 365046010761 5S rRNA interface [nucleotide binding]; other site 365046010762 CTC domain interface [polypeptide binding]; other site 365046010763 L16 interface [polypeptide binding]; other site 365046010764 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 365046010765 putative active site [active] 365046010766 catalytic residue [active] 365046010767 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 365046010768 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 365046010769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046010770 dimer interface [polypeptide binding]; other site 365046010771 conserved gate region; other site 365046010772 putative PBP binding loops; other site 365046010773 ABC-ATPase subunit interface; other site 365046010774 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 365046010775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046010776 dimer interface [polypeptide binding]; other site 365046010777 conserved gate region; other site 365046010778 putative PBP binding loops; other site 365046010779 ABC-ATPase subunit interface; other site 365046010780 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 365046010781 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 365046010782 Walker A/P-loop; other site 365046010783 ATP binding site [chemical binding]; other site 365046010784 Q-loop/lid; other site 365046010785 ABC transporter signature motif; other site 365046010786 Walker B; other site 365046010787 D-loop; other site 365046010788 H-loop/switch region; other site 365046010789 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 365046010790 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 365046010791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 365046010792 Walker A/P-loop; other site 365046010793 ATP binding site [chemical binding]; other site 365046010794 Q-loop/lid; other site 365046010795 ABC transporter signature motif; other site 365046010796 Walker B; other site 365046010797 D-loop; other site 365046010798 H-loop/switch region; other site 365046010799 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 365046010800 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 365046010801 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 365046010802 amidase; Provisional; Region: PRK07042 365046010803 Amidase; Region: Amidase; cl11426 365046010804 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 365046010805 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 365046010806 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 365046010807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 365046010808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046010809 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 365046010810 putative dimerization interface [polypeptide binding]; other site 365046010811 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 365046010812 galactarate dehydratase; Region: galactar-dH20; TIGR03248 365046010813 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 365046010814 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046010815 dihydroxy-acid dehydratase; Validated; Region: PRK06131 365046010816 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 365046010817 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 365046010818 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 365046010819 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 365046010820 active site 365046010821 (T/H)XGH motif; other site 365046010822 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 365046010823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046010824 S-adenosylmethionine binding site [chemical binding]; other site 365046010825 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 365046010826 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 365046010827 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 365046010828 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 365046010829 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 365046010830 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 365046010831 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 365046010832 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 365046010833 oligomeric interface; other site 365046010834 putative active site [active] 365046010835 homodimer interface [polypeptide binding]; other site 365046010836 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 365046010837 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 365046010838 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 365046010839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046010840 Walker A/P-loop; other site 365046010841 ATP binding site [chemical binding]; other site 365046010842 Q-loop/lid; other site 365046010843 ABC transporter signature motif; other site 365046010844 Walker B; other site 365046010845 D-loop; other site 365046010846 H-loop/switch region; other site 365046010847 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 365046010848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 365046010849 substrate binding pocket [chemical binding]; other site 365046010850 membrane-bound complex binding site; other site 365046010851 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 365046010852 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 365046010853 putative glycosyltransferase, TIGR04348 family; Region: TIGR04348 365046010854 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 365046010855 selenophosphate synthetase; Provisional; Region: PRK00943 365046010856 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 365046010857 dimerization interface [polypeptide binding]; other site 365046010858 putative ATP binding site [chemical binding]; other site 365046010859 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 365046010860 Protein of unknown function (DUF962); Region: DUF962; cl01879 365046010861 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 365046010862 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 365046010863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 365046010864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 365046010865 DNA binding residues [nucleotide binding] 365046010866 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046010867 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 365046010868 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 365046010869 Cu(I) binding site [ion binding]; other site 365046010870 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 365046010871 UbiA prenyltransferase family; Region: UbiA; pfam01040 365046010872 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 365046010873 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 365046010874 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 365046010875 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 365046010876 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 365046010877 Subunit III/VIIa interface [polypeptide binding]; other site 365046010878 Phospholipid binding site [chemical binding]; other site 365046010879 Subunit I/III interface [polypeptide binding]; other site 365046010880 Subunit III/VIb interface [polypeptide binding]; other site 365046010881 Subunit III/VIa interface; other site 365046010882 Subunit III/Vb interface [polypeptide binding]; other site 365046010883 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 365046010884 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 365046010885 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 365046010886 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 365046010887 Subunit I/III interface [polypeptide binding]; other site 365046010888 D-pathway; other site 365046010889 Subunit I/VIIc interface [polypeptide binding]; other site 365046010890 Subunit I/IV interface [polypeptide binding]; other site 365046010891 Subunit I/II interface [polypeptide binding]; other site 365046010892 Low-spin heme (heme a) binding site [chemical binding]; other site 365046010893 Subunit I/VIIa interface [polypeptide binding]; other site 365046010894 Subunit I/VIa interface [polypeptide binding]; other site 365046010895 Dimer interface; other site 365046010896 Putative water exit pathway; other site 365046010897 Binuclear center (heme a3/CuB) [ion binding]; other site 365046010898 K-pathway; other site 365046010899 Subunit I/Vb interface [polypeptide binding]; other site 365046010900 Putative proton exit pathway; other site 365046010901 Subunit I/VIb interface; other site 365046010902 Subunit I/VIc interface [polypeptide binding]; other site 365046010903 Electron transfer pathway; other site 365046010904 Subunit I/VIIIb interface [polypeptide binding]; other site 365046010905 Subunit I/VIIb interface [polypeptide binding]; other site 365046010906 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 365046010907 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 365046010908 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 365046010909 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 365046010910 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 365046010911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 365046010912 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 365046010913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 365046010914 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 365046010915 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 365046010916 putative active site [active] 365046010917 putative catalytic site [active] 365046010918 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 365046010919 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 365046010920 P-loop; other site 365046010921 Magnesium ion binding site [ion binding]; other site 365046010922 PAS domain S-box; Region: sensory_box; TIGR00229 365046010923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046010924 PAS domain; Region: PAS_9; pfam13426 365046010925 putative active site [active] 365046010926 heme pocket [chemical binding]; other site 365046010927 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046010928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046010929 putative active site [active] 365046010930 heme pocket [chemical binding]; other site 365046010931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046010932 dimer interface [polypeptide binding]; other site 365046010933 phosphorylation site [posttranslational modification] 365046010934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046010935 ATP binding site [chemical binding]; other site 365046010936 Mg2+ binding site [ion binding]; other site 365046010937 G-X-G motif; other site 365046010938 Response regulator receiver domain; Region: Response_reg; pfam00072 365046010939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046010940 active site 365046010941 phosphorylation site [posttranslational modification] 365046010942 intermolecular recognition site; other site 365046010943 dimerization interface [polypeptide binding]; other site 365046010944 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 365046010945 putative binding surface; other site 365046010946 active site 365046010947 Predicted membrane protein [Function unknown]; Region: COG2261 365046010948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046010949 dimer interface [polypeptide binding]; other site 365046010950 phosphorylation site [posttranslational modification] 365046010951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046010952 ATP binding site [chemical binding]; other site 365046010953 Mg2+ binding site [ion binding]; other site 365046010954 G-X-G motif; other site 365046010955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046010956 active site 365046010957 phosphorylation site [posttranslational modification] 365046010958 intermolecular recognition site; other site 365046010959 dimerization interface [polypeptide binding]; other site 365046010960 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 365046010961 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 365046010962 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 365046010963 dimer interface [polypeptide binding]; other site 365046010964 active site 365046010965 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 365046010966 Coenzyme A transferase; Region: CoA_trans; cl17247 365046010967 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 365046010968 DctM-like transporters; Region: DctM; pfam06808 365046010969 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 365046010970 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 365046010971 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 365046010972 Cytochrome c; Region: Cytochrom_C; cl11414 365046010973 Cytochrome c; Region: Cytochrom_C; cl11414 365046010974 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 365046010975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046010976 Walker A motif; other site 365046010977 ATP binding site [chemical binding]; other site 365046010978 Walker B motif; other site 365046010979 arginine finger; other site 365046010980 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 365046010981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 365046010982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 365046010983 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 365046010984 Cytochrome c; Region: Cytochrom_C; cl11414 365046010985 Cytochrome c; Region: Cytochrom_C; cl11414 365046010986 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 365046010987 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 365046010988 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 365046010989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 365046010990 spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187 365046010991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046010992 Walker A/P-loop; other site 365046010993 ATP binding site [chemical binding]; other site 365046010994 Q-loop/lid; other site 365046010995 ABC transporter signature motif; other site 365046010996 Walker B; other site 365046010997 D-loop; other site 365046010998 H-loop/switch region; other site 365046010999 TOBE domain; Region: TOBE_2; pfam08402 365046011000 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 365046011001 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 365046011002 putative acyl-acceptor binding pocket; other site 365046011003 dihydroorotase; Provisional; Region: PRK07627 365046011004 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 365046011005 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 365046011006 active site 365046011007 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 365046011008 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 365046011009 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 365046011010 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 365046011011 active site 365046011012 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 365046011013 hypothetical protein; Validated; Region: PRK00228 365046011014 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 365046011015 DNA photolyase; Region: DNA_photolyase; pfam00875 365046011016 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 365046011017 putative binding surface; other site 365046011018 active site 365046011019 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 365046011020 putative binding surface; other site 365046011021 active site 365046011022 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 365046011023 putative binding surface; other site 365046011024 active site 365046011025 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 365046011026 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 365046011027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046011028 ATP binding site [chemical binding]; other site 365046011029 Mg2+ binding site [ion binding]; other site 365046011030 G-X-G motif; other site 365046011031 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 365046011032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011033 Response regulator receiver domain; Region: Response_reg; pfam00072 365046011034 active site 365046011035 phosphorylation site [posttranslational modification] 365046011036 intermolecular recognition site; other site 365046011037 dimerization interface [polypeptide binding]; other site 365046011038 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 365046011039 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 365046011040 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 365046011041 dimer interface [polypeptide binding]; other site 365046011042 putative CheW interface [polypeptide binding]; other site 365046011043 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 365046011044 Response regulator receiver domain; Region: Response_reg; pfam00072 365046011045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011046 active site 365046011047 phosphorylation site [posttranslational modification] 365046011048 intermolecular recognition site; other site 365046011049 dimerization interface [polypeptide binding]; other site 365046011050 Response regulator receiver domain; Region: Response_reg; pfam00072 365046011051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011052 active site 365046011053 phosphorylation site [posttranslational modification] 365046011054 intermolecular recognition site; other site 365046011055 dimerization interface [polypeptide binding]; other site 365046011056 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 365046011057 substrate binding site [chemical binding]; other site 365046011058 ATP binding site [chemical binding]; other site 365046011059 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 365046011060 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 365046011061 inhibitor-cofactor binding pocket; inhibition site 365046011062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046011063 catalytic residue [active] 365046011064 VPS10 domain; Region: VPS10; smart00602 365046011065 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 365046011066 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 365046011067 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 365046011068 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 365046011069 ATP-grasp domain; Region: ATP-grasp_4; cl17255 365046011070 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 365046011071 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 365046011072 active site 365046011073 dimer interface [polypeptide binding]; other site 365046011074 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 365046011075 Ligand Binding Site [chemical binding]; other site 365046011076 Molecular Tunnel; other site 365046011077 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 365046011078 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 365046011079 purine monophosphate binding site [chemical binding]; other site 365046011080 dimer interface [polypeptide binding]; other site 365046011081 putative catalytic residues [active] 365046011082 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 365046011083 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 365046011084 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 365046011085 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 365046011086 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 365046011087 FMN binding site [chemical binding]; other site 365046011088 active site 365046011089 catalytic residues [active] 365046011090 substrate binding site [chemical binding]; other site 365046011091 Predicted membrane protein [Function unknown]; Region: COG1238 365046011092 GTP-binding protein YchF; Reviewed; Region: PRK09601 365046011093 YchF GTPase; Region: YchF; cd01900 365046011094 G1 box; other site 365046011095 GTP/Mg2+ binding site [chemical binding]; other site 365046011096 Switch I region; other site 365046011097 G2 box; other site 365046011098 Switch II region; other site 365046011099 G3 box; other site 365046011100 G4 box; other site 365046011101 G5 box; other site 365046011102 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 365046011103 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 365046011104 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 365046011105 MOSC domain; Region: MOSC; pfam03473 365046011106 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 365046011107 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 365046011108 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 365046011109 dimerization domain [polypeptide binding]; other site 365046011110 dimer interface [polypeptide binding]; other site 365046011111 catalytic residues [active] 365046011112 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 365046011113 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 365046011114 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 365046011115 protein binding site [polypeptide binding]; other site 365046011116 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 365046011117 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 365046011118 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 365046011119 active site 365046011120 AMP binding site [chemical binding]; other site 365046011121 homodimer interface [polypeptide binding]; other site 365046011122 acyl-activating enzyme (AAE) consensus motif; other site 365046011123 CoA binding site [chemical binding]; other site 365046011124 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046011125 CoenzymeA binding site [chemical binding]; other site 365046011126 subunit interaction site [polypeptide binding]; other site 365046011127 PHB binding site; other site 365046011128 enoyl-CoA hydratase; Provisional; Region: PRK08140 365046011129 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046011130 substrate binding site [chemical binding]; other site 365046011131 oxyanion hole (OAH) forming residues; other site 365046011132 trimer interface [polypeptide binding]; other site 365046011133 enoyl-CoA hydratase; Provisional; Region: PRK05862 365046011134 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046011135 substrate binding site [chemical binding]; other site 365046011136 oxyanion hole (OAH) forming residues; other site 365046011137 trimer interface [polypeptide binding]; other site 365046011138 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 365046011139 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 365046011140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 365046011141 FeS/SAM binding site; other site 365046011142 TRAM domain; Region: TRAM; pfam01938 365046011143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046011144 dimer interface [polypeptide binding]; other site 365046011145 phosphorylation site [posttranslational modification] 365046011146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046011147 ATP binding site [chemical binding]; other site 365046011148 Mg2+ binding site [ion binding]; other site 365046011149 G-X-G motif; other site 365046011150 response regulator GlrR; Provisional; Region: PRK15115 365046011151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011152 active site 365046011153 phosphorylation site [posttranslational modification] 365046011154 intermolecular recognition site; other site 365046011155 dimerization interface [polypeptide binding]; other site 365046011156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046011157 Walker A motif; other site 365046011158 ATP binding site [chemical binding]; other site 365046011159 Walker B motif; other site 365046011160 arginine finger; other site 365046011161 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 365046011162 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 365046011163 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 365046011164 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 365046011165 Ligand binding site; other site 365046011166 DXD motif; other site 365046011167 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046011168 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 365046011169 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 365046011170 metal binding site [ion binding]; metal-binding site 365046011171 putative dimer interface [polypeptide binding]; other site 365046011172 signal recognition particle protein; Provisional; Region: PRK10867 365046011173 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 365046011174 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 365046011175 GTP binding site [chemical binding]; other site 365046011176 Signal peptide binding domain; Region: SRP_SPB; pfam02978 365046011177 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 365046011178 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 365046011179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046011180 putative active site [active] 365046011181 heme pocket [chemical binding]; other site 365046011182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046011183 dimer interface [polypeptide binding]; other site 365046011184 phosphorylation site [posttranslational modification] 365046011185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046011186 ATP binding site [chemical binding]; other site 365046011187 Mg2+ binding site [ion binding]; other site 365046011188 G-X-G motif; other site 365046011189 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 365046011190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011191 active site 365046011192 phosphorylation site [posttranslational modification] 365046011193 intermolecular recognition site; other site 365046011194 dimerization interface [polypeptide binding]; other site 365046011195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046011196 Walker A motif; other site 365046011197 ATP binding site [chemical binding]; other site 365046011198 Walker B motif; other site 365046011199 arginine finger; other site 365046011200 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 365046011201 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 365046011202 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 365046011203 amidase catalytic site [active] 365046011204 Zn binding residues [ion binding]; other site 365046011205 substrate binding site [chemical binding]; other site 365046011206 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 365046011207 ATP cone domain; Region: ATP-cone; pfam03477 365046011208 ATP cone domain; Region: ATP-cone; pfam03477 365046011209 Class I ribonucleotide reductase; Region: RNR_I; cd01679 365046011210 active site 365046011211 dimer interface [polypeptide binding]; other site 365046011212 catalytic residues [active] 365046011213 effector binding site; other site 365046011214 R2 peptide binding site; other site 365046011215 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 365046011216 dimer interface [polypeptide binding]; other site 365046011217 putative radical transfer pathway; other site 365046011218 diiron center [ion binding]; other site 365046011219 tyrosyl radical; other site 365046011220 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 365046011221 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 365046011222 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 365046011223 mce related protein; Region: MCE; pfam02470 365046011224 Permease; Region: Permease; cl00510 365046011225 AMP nucleosidase; Provisional; Region: PRK08292 365046011226 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 365046011227 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 365046011228 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 365046011229 nodulation ABC transporter NodI; Provisional; Region: PRK13537 365046011230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 365046011231 Walker A/P-loop; other site 365046011232 ATP binding site [chemical binding]; other site 365046011233 Q-loop/lid; other site 365046011234 ABC transporter signature motif; other site 365046011235 Walker B; other site 365046011236 D-loop; other site 365046011237 H-loop/switch region; other site 365046011238 ABC-2 type transporter; Region: ABC2_membrane; cl17235 365046011239 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 365046011240 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 365046011241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 365046011242 putative DNA binding site [nucleotide binding]; other site 365046011243 putative Zn2+ binding site [ion binding]; other site 365046011244 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 365046011245 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 365046011246 serine/threonine protein kinase; Provisional; Region: PRK11768 365046011247 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 365046011248 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 365046011249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 365046011250 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 365046011251 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 365046011252 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 365046011253 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 365046011254 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 365046011255 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 365046011256 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 365046011257 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 365046011258 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 365046011259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 365046011260 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046011261 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 365046011262 heat shock protein 90; Provisional; Region: PRK05218 365046011263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046011264 ATP binding site [chemical binding]; other site 365046011265 Mg2+ binding site [ion binding]; other site 365046011266 G-X-G motif; other site 365046011267 sensor protein QseC; Provisional; Region: PRK10337 365046011268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046011269 dimer interface [polypeptide binding]; other site 365046011270 phosphorylation site [posttranslational modification] 365046011271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046011272 ATP binding site [chemical binding]; other site 365046011273 Mg2+ binding site [ion binding]; other site 365046011274 G-X-G motif; other site 365046011275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 365046011276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011277 active site 365046011278 phosphorylation site [posttranslational modification] 365046011279 intermolecular recognition site; other site 365046011280 dimerization interface [polypeptide binding]; other site 365046011281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046011282 DNA binding site [nucleotide binding] 365046011283 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 365046011284 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 365046011285 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 365046011286 PapC N-terminal domain; Region: PapC_N; pfam13954 365046011287 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 365046011288 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 365046011289 PapC C-terminal domain; Region: PapC_C; pfam13953 365046011290 Spore Coat Protein U domain; Region: SCPU; cl02253 365046011291 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 365046011292 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 365046011293 RNA binding surface [nucleotide binding]; other site 365046011294 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 365046011295 active site 365046011296 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 365046011297 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 365046011298 ligand binding site [chemical binding]; other site 365046011299 flexible hinge region; other site 365046011300 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 365046011301 non-specific DNA interactions [nucleotide binding]; other site 365046011302 DNA binding site [nucleotide binding] 365046011303 sequence specific DNA binding site [nucleotide binding]; other site 365046011304 putative cAMP binding site [chemical binding]; other site 365046011305 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 365046011306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046011307 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 365046011308 acyl-activating enzyme (AAE) consensus motif; other site 365046011309 putative AMP binding site [chemical binding]; other site 365046011310 putative active site [active] 365046011311 putative CoA binding site [chemical binding]; other site 365046011312 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 365046011313 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 365046011314 Walker A/P-loop; other site 365046011315 ATP binding site [chemical binding]; other site 365046011316 Q-loop/lid; other site 365046011317 ABC transporter signature motif; other site 365046011318 Walker B; other site 365046011319 D-loop; other site 365046011320 H-loop/switch region; other site 365046011321 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 365046011322 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 365046011323 TM-ABC transporter signature motif; other site 365046011324 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 365046011325 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 365046011326 TM-ABC transporter signature motif; other site 365046011327 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 365046011328 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 365046011329 putative ligand binding site [chemical binding]; other site 365046011330 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 365046011331 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 365046011332 Walker A/P-loop; other site 365046011333 ATP binding site [chemical binding]; other site 365046011334 Q-loop/lid; other site 365046011335 ABC transporter signature motif; other site 365046011336 Walker B; other site 365046011337 D-loop; other site 365046011338 H-loop/switch region; other site 365046011339 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 365046011340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046011341 acyl-activating enzyme (AAE) consensus motif; other site 365046011342 active site 365046011343 AMP binding site [chemical binding]; other site 365046011344 CoA binding site [chemical binding]; other site 365046011345 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046011346 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046011347 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 365046011348 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 365046011349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046011350 S-adenosylmethionine binding site [chemical binding]; other site 365046011351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 365046011352 MarR family; Region: MarR; pfam01047 365046011353 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 365046011354 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 365046011355 acyl-activating enzyme (AAE) consensus motif; other site 365046011356 AMP binding site [chemical binding]; other site 365046011357 active site 365046011358 CoA binding site [chemical binding]; other site 365046011359 type II secretion system protein F; Region: GspF; TIGR02120 365046011360 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 365046011361 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 365046011362 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 365046011363 EamA-like transporter family; Region: EamA; pfam00892 365046011364 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 365046011365 EamA-like transporter family; Region: EamA; pfam00892 365046011366 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 365046011367 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 365046011368 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046011369 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 365046011370 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 365046011371 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046011372 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 365046011373 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 365046011374 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 365046011375 oligomerisation interface [polypeptide binding]; other site 365046011376 mobile loop; other site 365046011377 roof hairpin; other site 365046011378 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 365046011379 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 365046011380 ring oligomerisation interface [polypeptide binding]; other site 365046011381 ATP/Mg binding site [chemical binding]; other site 365046011382 stacking interactions; other site 365046011383 hinge regions; other site 365046011384 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 365046011385 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 365046011386 active site 365046011387 dimer interface [polypeptide binding]; other site 365046011388 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 365046011389 dimer interface [polypeptide binding]; other site 365046011390 active site 365046011391 transaldolase-like protein; Provisional; Region: PTZ00411 365046011392 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 365046011393 active site 365046011394 dimer interface [polypeptide binding]; other site 365046011395 catalytic residue [active] 365046011396 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 365046011397 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 365046011398 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 365046011399 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 365046011400 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 365046011401 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 365046011402 putative active site [active] 365046011403 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 365046011404 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 365046011405 Walker A/P-loop; other site 365046011406 ATP binding site [chemical binding]; other site 365046011407 Q-loop/lid; other site 365046011408 ABC transporter signature motif; other site 365046011409 Walker B; other site 365046011410 D-loop; other site 365046011411 H-loop/switch region; other site 365046011412 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 365046011413 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 365046011414 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 365046011415 Walker A/P-loop; other site 365046011416 ATP binding site [chemical binding]; other site 365046011417 Q-loop/lid; other site 365046011418 ABC transporter signature motif; other site 365046011419 Walker B; other site 365046011420 D-loop; other site 365046011421 H-loop/switch region; other site 365046011422 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 365046011423 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 365046011424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046011425 dimer interface [polypeptide binding]; other site 365046011426 conserved gate region; other site 365046011427 putative PBP binding loops; other site 365046011428 ABC-ATPase subunit interface; other site 365046011429 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 365046011430 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 365046011431 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 365046011432 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 365046011433 metal binding site [ion binding]; metal-binding site 365046011434 putative dimer interface [polypeptide binding]; other site 365046011435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 365046011436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 365046011437 dimer interface [polypeptide binding]; other site 365046011438 conserved gate region; other site 365046011439 putative PBP binding loops; other site 365046011440 ABC-ATPase subunit interface; other site 365046011441 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 365046011442 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 365046011443 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 365046011444 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 365046011445 eyelet of channel; other site 365046011446 trimer interface [polypeptide binding]; other site 365046011447 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 365046011448 dinuclear metal binding motif [ion binding]; other site 365046011449 OsmC-like protein; Region: OsmC; cl00767 365046011450 threonine dehydratase; Reviewed; Region: PRK09224 365046011451 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 365046011452 tetramer interface [polypeptide binding]; other site 365046011453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046011454 catalytic residue [active] 365046011455 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 365046011456 putative Ile/Val binding site [chemical binding]; other site 365046011457 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 365046011458 putative Ile/Val binding site [chemical binding]; other site 365046011459 cobalamin synthase; Reviewed; Region: cobS; PRK00235 365046011460 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 365046011461 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 365046011462 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 365046011463 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 365046011464 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 365046011465 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 365046011466 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 365046011467 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 365046011468 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 365046011469 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 365046011470 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 365046011471 type II secretion system protein E; Region: type_II_gspE; TIGR02533 365046011472 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 365046011473 Walker A motif; other site 365046011474 ATP binding site [chemical binding]; other site 365046011475 Walker B motif; other site 365046011476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 365046011477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046011478 dimer interface [polypeptide binding]; other site 365046011479 phosphorylation site [posttranslational modification] 365046011480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046011481 ATP binding site [chemical binding]; other site 365046011482 Mg2+ binding site [ion binding]; other site 365046011483 G-X-G motif; other site 365046011484 circadian clock protein KaiC; Reviewed; Region: PRK09302 365046011485 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 365046011486 Walker A motif; other site 365046011487 ATP binding site [chemical binding]; other site 365046011488 Walker B motif; other site 365046011489 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 365046011490 Walker A motif; other site 365046011491 ATP binding site [chemical binding]; other site 365046011492 Walker B motif; other site 365046011493 Response regulator receiver domain; Region: Response_reg; pfam00072 365046011494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011495 active site 365046011496 phosphorylation site [posttranslational modification] 365046011497 intermolecular recognition site; other site 365046011498 dimerization interface [polypeptide binding]; other site 365046011499 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046011500 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 365046011501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046011502 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 365046011503 putative dimerization interface [polypeptide binding]; other site 365046011504 tricarballylate dehydrogenase; Validated; Region: PRK08274 365046011505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 365046011506 tricarballylate utilization protein B; Provisional; Region: PRK15033 365046011507 aldolase II superfamily protein; Provisional; Region: PRK07044 365046011508 intersubunit interface [polypeptide binding]; other site 365046011509 active site 365046011510 Zn2+ binding site [ion binding]; other site 365046011511 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046011512 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 365046011513 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 365046011514 NAD binding site [chemical binding]; other site 365046011515 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 365046011516 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 365046011517 Metal-binding active site; metal-binding site 365046011518 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046011519 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 365046011520 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 365046011521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 365046011522 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 365046011523 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 365046011524 putative NAD(P) binding site [chemical binding]; other site 365046011525 catalytic Zn binding site [ion binding]; other site 365046011526 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 365046011527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046011528 putative substrate translocation pore; other site 365046011529 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 365046011530 Response regulator receiver domain; Region: Response_reg; pfam00072 365046011531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011532 active site 365046011533 phosphorylation site [posttranslational modification] 365046011534 intermolecular recognition site; other site 365046011535 dimerization interface [polypeptide binding]; other site 365046011536 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 365046011537 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 365046011538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 365046011539 dimerization interface [polypeptide binding]; other site 365046011540 PAS domain; Region: PAS; smart00091 365046011541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046011542 dimer interface [polypeptide binding]; other site 365046011543 phosphorylation site [posttranslational modification] 365046011544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046011545 ATP binding site [chemical binding]; other site 365046011546 Mg2+ binding site [ion binding]; other site 365046011547 G-X-G motif; other site 365046011548 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 365046011549 16S rRNA methyltransferase B; Provisional; Region: PRK10901 365046011550 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 365046011551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046011552 S-adenosylmethionine binding site [chemical binding]; other site 365046011553 LemA family; Region: LemA; cl00742 365046011554 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 365046011555 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 365046011556 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 365046011557 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 365046011558 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 365046011559 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 365046011560 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 365046011561 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 365046011562 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 365046011563 DNA binding site [nucleotide binding] 365046011564 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 365046011565 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 365046011566 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 365046011567 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 365046011568 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 365046011569 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 365046011570 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 365046011571 RPB3 interaction site [polypeptide binding]; other site 365046011572 RPB1 interaction site [polypeptide binding]; other site 365046011573 RPB11 interaction site [polypeptide binding]; other site 365046011574 RPB10 interaction site [polypeptide binding]; other site 365046011575 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 365046011576 peripheral dimer interface [polypeptide binding]; other site 365046011577 core dimer interface [polypeptide binding]; other site 365046011578 L10 interface [polypeptide binding]; other site 365046011579 L11 interface [polypeptide binding]; other site 365046011580 putative EF-Tu interaction site [polypeptide binding]; other site 365046011581 putative EF-G interaction site [polypeptide binding]; other site 365046011582 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 365046011583 23S rRNA interface [nucleotide binding]; other site 365046011584 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 365046011585 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 365046011586 mRNA/rRNA interface [nucleotide binding]; other site 365046011587 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 365046011588 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 365046011589 23S rRNA interface [nucleotide binding]; other site 365046011590 L7/L12 interface [polypeptide binding]; other site 365046011591 putative thiostrepton binding site; other site 365046011592 L25 interface [polypeptide binding]; other site 365046011593 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 365046011594 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 365046011595 putative homodimer interface [polypeptide binding]; other site 365046011596 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 365046011597 heterodimer interface [polypeptide binding]; other site 365046011598 homodimer interface [polypeptide binding]; other site 365046011599 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 365046011600 elongation factor Tu; Reviewed; Region: PRK00049 365046011601 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 365046011602 G1 box; other site 365046011603 GEF interaction site [polypeptide binding]; other site 365046011604 GTP/Mg2+ binding site [chemical binding]; other site 365046011605 Switch I region; other site 365046011606 G2 box; other site 365046011607 G3 box; other site 365046011608 Switch II region; other site 365046011609 G4 box; other site 365046011610 G5 box; other site 365046011611 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 365046011612 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 365046011613 Antibiotic Binding Site [chemical binding]; other site 365046011614 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 365046011615 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 365046011616 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 365046011617 ligand binding site [chemical binding]; other site 365046011618 active site 365046011619 UGI interface [polypeptide binding]; other site 365046011620 catalytic site [active] 365046011621 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 365046011622 active site 365046011623 ribulose/triose binding site [chemical binding]; other site 365046011624 phosphate binding site [ion binding]; other site 365046011625 substrate (anthranilate) binding pocket [chemical binding]; other site 365046011626 product (indole) binding pocket [chemical binding]; other site 365046011627 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 365046011628 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 365046011629 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 365046011630 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 365046011631 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 365046011632 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 365046011633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 365046011634 catalytic residue [active] 365046011635 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 365046011636 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 365046011637 glutamine binding [chemical binding]; other site 365046011638 catalytic triad [active] 365046011639 anthranilate synthase component I; Provisional; Region: PRK13565 365046011640 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 365046011641 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 365046011642 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 365046011643 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 365046011644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046011645 motif II; other site 365046011646 hydroperoxidase II; Provisional; Region: katE; PRK11249 365046011647 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 365046011648 heme binding pocket [chemical binding]; other site 365046011649 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 365046011650 domain interactions; other site 365046011651 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 365046011652 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 365046011653 substrate binding site [chemical binding]; other site 365046011654 hexamer interface [polypeptide binding]; other site 365046011655 metal binding site [ion binding]; metal-binding site 365046011656 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 365046011657 Site-specific recombinase; Region: SpecificRecomb; cl15411 365046011658 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 365046011659 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 365046011660 thiamine monophosphate kinase; Provisional; Region: PRK05731 365046011661 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 365046011662 ATP binding site [chemical binding]; other site 365046011663 dimerization interface [polypeptide binding]; other site 365046011664 Staphylococcal nuclease homologues; Region: SNc; smart00318 365046011665 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 365046011666 Catalytic site; other site 365046011667 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 365046011668 tetramer interfaces [polypeptide binding]; other site 365046011669 binuclear metal-binding site [ion binding]; other site 365046011670 Competence-damaged protein; Region: CinA; pfam02464 365046011671 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 365046011672 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 365046011673 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 365046011674 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 365046011675 alphaNTD homodimer interface [polypeptide binding]; other site 365046011676 alphaNTD - beta interaction site [polypeptide binding]; other site 365046011677 alphaNTD - beta' interaction site [polypeptide binding]; other site 365046011678 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 365046011679 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 365046011680 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 365046011681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 365046011682 RNA binding surface [nucleotide binding]; other site 365046011683 30S ribosomal protein S11; Validated; Region: PRK05309 365046011684 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 365046011685 30S ribosomal protein S13; Region: bact_S13; TIGR03631 365046011686 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 365046011687 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 365046011688 rRNA binding site [nucleotide binding]; other site 365046011689 predicted 30S ribosome binding site; other site 365046011690 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 365046011691 SecY translocase; Region: SecY; pfam00344 365046011692 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 365046011693 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 365046011694 23S rRNA binding site [nucleotide binding]; other site 365046011695 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 365046011696 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 365046011697 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 365046011698 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 365046011699 5S rRNA interface [nucleotide binding]; other site 365046011700 23S rRNA interface [nucleotide binding]; other site 365046011701 L5 interface [polypeptide binding]; other site 365046011702 ribosomal protein L6, bacterial type; Region: L6_bact; TIGR03654 365046011703 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 365046011704 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 365046011705 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 365046011706 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 365046011707 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 365046011708 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 365046011709 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 365046011710 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 365046011711 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 365046011712 RNA binding site [nucleotide binding]; other site 365046011713 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 365046011714 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 365046011715 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 365046011716 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 365046011717 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 365046011718 UbiA prenyltransferase family; Region: UbiA; pfam01040 365046011719 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 365046011720 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 365046011721 dimerization interface [polypeptide binding]; other site 365046011722 DPS ferroxidase diiron center [ion binding]; other site 365046011723 ion pore; other site 365046011724 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 365046011725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046011726 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 365046011727 dimerization interface [polypeptide binding]; other site 365046011728 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 365046011729 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 365046011730 generic binding surface II; other site 365046011731 ssDNA binding site; other site 365046011732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 365046011733 ATP binding site [chemical binding]; other site 365046011734 putative Mg++ binding site [ion binding]; other site 365046011735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 365046011736 nucleotide binding region [chemical binding]; other site 365046011737 ATP-binding site [chemical binding]; other site 365046011738 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 365046011739 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 365046011740 FecR protein; Region: FecR; pfam04773 365046011741 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 365046011742 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 365046011743 Protein of unknown function (DUF456); Region: DUF456; pfam04306 365046011744 Double zinc ribbon; Region: DZR; pfam12773 365046011745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046011746 putative substrate translocation pore; other site 365046011747 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 365046011748 putative acyl-acceptor binding pocket; other site 365046011749 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 365046011750 Beta-lactamase; Region: Beta-lactamase; pfam00144 365046011751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 365046011752 FIST N domain; Region: FIST; smart00897 365046011753 FIST C domain; Region: FIST_C; pfam10442 365046011754 Protein of unknown function (DUF461); Region: DUF461; pfam04314 365046011755 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 365046011756 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 365046011757 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 365046011758 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 365046011759 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 365046011760 substrate binding site [chemical binding]; other site 365046011761 oxyanion hole (OAH) forming residues; other site 365046011762 trimer interface [polypeptide binding]; other site 365046011763 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 365046011764 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 365046011765 putative metal binding site [ion binding]; other site 365046011766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046011767 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 365046011768 active site 365046011769 motif I; other site 365046011770 motif II; other site 365046011771 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 365046011772 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 365046011773 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 365046011774 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 365046011775 active site 365046011776 homotetramer interface [polypeptide binding]; other site 365046011777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046011778 putative substrate translocation pore; other site 365046011779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046011780 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 365046011781 Fasciclin domain; Region: Fasciclin; pfam02469 365046011782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 365046011783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 365046011784 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 365046011785 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 365046011786 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 365046011787 Transcriptional regulator [Transcription]; Region: IclR; COG1414 365046011788 Bacterial transcriptional regulator; Region: IclR; pfam01614 365046011789 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 365046011790 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 365046011791 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 365046011792 Putative ammonia monooxygenase; Region: AmoA; pfam05145 365046011793 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 365046011794 Protein of unknown function, DUF399; Region: DUF399; cl01139 365046011795 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 365046011796 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 365046011797 inhibitor-cofactor binding pocket; inhibition site 365046011798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 365046011799 catalytic residue [active] 365046011800 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 365046011801 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 365046011802 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 365046011803 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 365046011804 putative active site [active] 365046011805 putative substrate binding site [chemical binding]; other site 365046011806 putative cosubstrate binding site; other site 365046011807 catalytic site [active] 365046011808 MT-A70; Region: MT-A70; cl01947 365046011809 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 365046011810 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 365046011811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 365046011812 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 365046011813 dimerization interface [polypeptide binding]; other site 365046011814 substrate binding pocket [chemical binding]; other site 365046011815 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 365046011816 CoenzymeA binding site [chemical binding]; other site 365046011817 subunit interaction site [polypeptide binding]; other site 365046011818 PHB binding site; other site 365046011819 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 365046011820 FAD binding domain; Region: FAD_binding_4; pfam01565 365046011821 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 365046011822 Fe-S cluster binding site [ion binding]; other site 365046011823 active site 365046011824 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 365046011825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 365046011826 Coenzyme A binding pocket [chemical binding]; other site 365046011827 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 365046011828 Glycoprotease family; Region: Peptidase_M22; pfam00814 365046011829 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 365046011830 Secretory lipase; Region: LIP; pfam03583 365046011831 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 365046011832 active site 365046011833 catalytic triad [active] 365046011834 oxyanion hole [active] 365046011835 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 365046011836 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 365046011837 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 365046011838 ATP-grasp domain; Region: ATP-grasp; pfam02222 365046011839 AIR carboxylase; Region: AIRC; cl00310 365046011840 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 365046011841 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 365046011842 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 365046011843 Predicted transcriptional regulator [Transcription]; Region: COG3905 365046011844 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 365046011845 active site 365046011846 ATP binding site [chemical binding]; other site 365046011847 substrate binding site [chemical binding]; other site 365046011848 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 365046011849 putative active site [active] 365046011850 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 365046011851 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 365046011852 intersubunit interface [polypeptide binding]; other site 365046011853 active site 365046011854 zinc binding site [ion binding]; other site 365046011855 Na+ binding site [ion binding]; other site 365046011856 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 365046011857 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 365046011858 pyruvate kinase; Provisional; Region: PRK05826 365046011859 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 365046011860 domain interfaces; other site 365046011861 active site 365046011862 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 365046011863 Phosphoglycerate kinase; Region: PGK; pfam00162 365046011864 substrate binding site [chemical binding]; other site 365046011865 hinge regions; other site 365046011866 ADP binding site [chemical binding]; other site 365046011867 catalytic site [active] 365046011868 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 365046011869 AzlC protein; Region: AzlC; pfam03591 365046011870 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 365046011871 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 365046011872 putative active site [active] 365046011873 substrate binding site [chemical binding]; other site 365046011874 putative cosubstrate binding site; other site 365046011875 catalytic site [active] 365046011876 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 365046011877 substrate binding site [chemical binding]; other site 365046011878 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 365046011879 active site 365046011880 catalytic residues [active] 365046011881 metal binding site [ion binding]; metal-binding site 365046011882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 365046011883 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 365046011884 DNA protecting protein DprA; Region: dprA; TIGR00732 365046011885 Protein of unknown function (DUF494); Region: DUF494; pfam04361 365046011886 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 365046011887 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 365046011888 Protein export membrane protein; Region: SecD_SecF; pfam02355 365046011889 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 365046011890 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 365046011891 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 365046011892 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 365046011893 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 365046011894 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 365046011895 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 365046011896 dimer interface [polypeptide binding]; other site 365046011897 PYR/PP interface [polypeptide binding]; other site 365046011898 TPP binding site [chemical binding]; other site 365046011899 substrate binding site [chemical binding]; other site 365046011900 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 365046011901 TPP-binding site; other site 365046011902 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 365046011903 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 365046011904 MltA specific insert domain; Region: MltA; smart00925 365046011905 3D domain; Region: 3D; pfam06725 365046011906 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 365046011907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046011908 active site 365046011909 phosphorylation site [posttranslational modification] 365046011910 intermolecular recognition site; other site 365046011911 dimerization interface [polypeptide binding]; other site 365046011912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 365046011913 DNA binding residues [nucleotide binding] 365046011914 dimerization interface [polypeptide binding]; other site 365046011915 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 365046011916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 365046011917 putative active site [active] 365046011918 heme pocket [chemical binding]; other site 365046011919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046011920 dimer interface [polypeptide binding]; other site 365046011921 phosphorylation site [posttranslational modification] 365046011922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046011923 ATP binding site [chemical binding]; other site 365046011924 Mg2+ binding site [ion binding]; other site 365046011925 G-X-G motif; other site 365046011926 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 365046011927 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 365046011928 putative active site [active] 365046011929 catalytic triad [active] 365046011930 dimer interface [polypeptide binding]; other site 365046011931 TIGR02099 family protein; Region: TIGR02099 365046011932 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 365046011933 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 365046011934 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 365046011935 metal binding triad; other site 365046011936 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 365046011937 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 365046011938 metal binding triad; other site 365046011939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 365046011940 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 365046011941 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 365046011942 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 365046011943 HlyD family secretion protein; Region: HlyD_3; pfam13437 365046011944 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 365046011945 Protein export membrane protein; Region: SecD_SecF; cl14618 365046011946 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 365046011947 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 365046011948 active site 365046011949 nucleotide binding site [chemical binding]; other site 365046011950 HIGH motif; other site 365046011951 KMSKS motif; other site 365046011952 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 365046011953 dinuclear metal binding motif [ion binding]; other site 365046011954 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 365046011955 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 365046011956 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 365046011957 catalytic residues [active] 365046011958 dimer interface [polypeptide binding]; other site 365046011959 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 365046011960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 365046011961 hydroxyglutarate oxidase; Provisional; Region: PRK11728 365046011962 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 365046011963 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 365046011964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 365046011965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046011966 S-adenosylmethionine binding site [chemical binding]; other site 365046011967 MFS/sugar transport protein; Region: MFS_2; pfam13347 365046011968 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 365046011969 short chain dehydrogenase; Provisional; Region: PRK06101 365046011970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046011971 NAD(P) binding site [chemical binding]; other site 365046011972 active site 365046011973 putative glutathione S-transferase; Provisional; Region: PRK10357 365046011974 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 365046011975 putative C-terminal domain interface [polypeptide binding]; other site 365046011976 putative GSH binding site (G-site) [chemical binding]; other site 365046011977 putative dimer interface [polypeptide binding]; other site 365046011978 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 365046011979 dimer interface [polypeptide binding]; other site 365046011980 N-terminal domain interface [polypeptide binding]; other site 365046011981 putative substrate binding pocket (H-site) [chemical binding]; other site 365046011982 adenylosuccinate lyase; Provisional; Region: PRK09285 365046011983 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 365046011984 tetramer interface [polypeptide binding]; other site 365046011985 active site 365046011986 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 365046011987 YaeQ protein; Region: YaeQ; pfam07152 365046011988 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 365046011989 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 365046011990 Membrane protein of unknown function; Region: DUF360; pfam04020 365046011991 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 365046011992 Peptidase family M48; Region: Peptidase_M48; cl12018 365046011993 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 365046011994 trimer interface [polypeptide binding]; other site 365046011995 dimer interface [polypeptide binding]; other site 365046011996 putative active site [active] 365046011997 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 365046011998 Pilin (bacterial filament); Region: Pilin; pfam00114 365046011999 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 365046012000 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 365046012001 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 365046012002 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 365046012003 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 365046012004 Walker A motif; other site 365046012005 ATP binding site [chemical binding]; other site 365046012006 Walker B motif; other site 365046012007 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 365046012008 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 365046012009 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 365046012010 phosphopeptide binding site; other site 365046012011 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 365046012012 active site 365046012013 Protein phosphatase 2C; Region: PP2C; pfam00481 365046012014 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 365046012015 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 365046012016 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 365046012017 active site 365046012018 ATP binding site [chemical binding]; other site 365046012019 substrate binding site [chemical binding]; other site 365046012020 activation loop (A-loop); other site 365046012021 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 365046012022 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 365046012023 CoA binding domain; Region: CoA_binding; smart00881 365046012024 CoA-ligase; Region: Ligase_CoA; pfam00549 365046012025 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 365046012026 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 365046012027 CoA-ligase; Region: Ligase_CoA; pfam00549 365046012028 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 365046012029 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 365046012030 recombination regulator RecX; Reviewed; Region: recX; PRK00117 365046012031 recombinase A; Provisional; Region: recA; PRK09354 365046012032 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 365046012033 hexamer interface [polypeptide binding]; other site 365046012034 Walker A motif; other site 365046012035 ATP binding site [chemical binding]; other site 365046012036 Walker B motif; other site 365046012037 Transcriptional regulators [Transcription]; Region: MarR; COG1846 365046012038 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 365046012039 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 365046012040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 365046012041 active site 365046012042 phosphorylation site [posttranslational modification] 365046012043 intermolecular recognition site; other site 365046012044 dimerization interface [polypeptide binding]; other site 365046012045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 365046012046 DNA binding site [nucleotide binding] 365046012047 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 365046012048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 365046012049 dimer interface [polypeptide binding]; other site 365046012050 phosphorylation site [posttranslational modification] 365046012051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 365046012052 ATP binding site [chemical binding]; other site 365046012053 Mg2+ binding site [ion binding]; other site 365046012054 G-X-G motif; other site 365046012055 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 365046012056 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 365046012057 C-terminal domain interface [polypeptide binding]; other site 365046012058 GSH binding site (G-site) [chemical binding]; other site 365046012059 dimer interface [polypeptide binding]; other site 365046012060 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 365046012061 dimer interface [polypeptide binding]; other site 365046012062 N-terminal domain interface [polypeptide binding]; other site 365046012063 substrate binding pocket (H-site) [chemical binding]; other site 365046012064 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 365046012065 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 365046012066 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 365046012067 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 365046012068 Proteins containing SET domain [General function prediction only]; Region: COG2940 365046012069 DNA topoisomerase III; Validated; Region: PRK08173 365046012070 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 365046012071 active site 365046012072 putative interdomain interaction site [polypeptide binding]; other site 365046012073 putative metal-binding site [ion binding]; other site 365046012074 putative nucleotide binding site [chemical binding]; other site 365046012075 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 365046012076 domain I; other site 365046012077 DNA binding groove [nucleotide binding] 365046012078 phosphate binding site [ion binding]; other site 365046012079 domain II; other site 365046012080 domain III; other site 365046012081 nucleotide binding site [chemical binding]; other site 365046012082 catalytic site [active] 365046012083 domain IV; other site 365046012084 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 365046012085 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 365046012086 SWI complex, BAF60b domains; Region: SWIB; smart00151 365046012087 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 365046012088 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 365046012089 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 365046012090 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 365046012091 NAD(P) binding site [chemical binding]; other site 365046012092 catalytic residues [active] 365046012093 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 365046012094 Peptidase C26; Region: Peptidase_C26; pfam07722 365046012095 catalytic triad [active] 365046012096 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 365046012097 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 365046012098 putative active site [active] 365046012099 metal binding site [ion binding]; metal-binding site 365046012100 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 365046012101 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 365046012102 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 365046012103 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 365046012104 Cytochrome P450; Region: p450; cl12078 365046012105 Hemerythrin-like domain; Region: Hr-like; cd12108 365046012106 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 365046012107 hypothetical protein; Provisional; Region: PRK06194 365046012108 classical (c) SDRs; Region: SDR_c; cd05233 365046012109 NAD(P) binding site [chemical binding]; other site 365046012110 active site 365046012111 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 365046012112 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 365046012113 ProQ/FINO family; Region: ProQ; pfam04352 365046012114 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 365046012115 Methyltransferase domain; Region: Methyltransf_31; pfam13847 365046012116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046012117 S-adenosylmethionine binding site [chemical binding]; other site 365046012118 short chain dehydrogenase; Provisional; Region: PRK06125 365046012119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046012120 NAD(P) binding site [chemical binding]; other site 365046012121 active site 365046012122 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 365046012123 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 365046012124 tetramer interface [polypeptide binding]; other site 365046012125 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 365046012126 active site 365046012127 Mg2+/Mn2+ binding site [ion binding]; other site 365046012128 Propionate catabolism activator; Region: PrpR_N; pfam06506 365046012129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 365046012130 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 365046012131 Walker A motif; other site 365046012132 ATP binding site [chemical binding]; other site 365046012133 Walker B motif; other site 365046012134 arginine finger; other site 365046012135 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 365046012136 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 365046012137 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 365046012138 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 365046012139 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 365046012140 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 365046012141 TPP-binding site [chemical binding]; other site 365046012142 dimer interface [polypeptide binding]; other site 365046012143 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 365046012144 PYR/PP interface [polypeptide binding]; other site 365046012145 dimer interface [polypeptide binding]; other site 365046012146 TPP binding site [chemical binding]; other site 365046012147 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 365046012148 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 365046012149 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 365046012150 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 365046012151 Substrate binding site; other site 365046012152 metal-binding site 365046012153 proline aminopeptidase P II; Provisional; Region: PRK10879 365046012154 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 365046012155 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 365046012156 active site 365046012157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 365046012158 AAA domain; Region: AAA_23; pfam13476 365046012159 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 365046012160 O-Antigen ligase; Region: Wzy_C; pfam04932 365046012161 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 365046012162 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 365046012163 malic enzyme; Reviewed; Region: PRK12862 365046012164 Malic enzyme, N-terminal domain; Region: malic; pfam00390 365046012165 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 365046012166 putative NAD(P) binding site [chemical binding]; other site 365046012167 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 365046012168 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 365046012169 active site 365046012170 barstar interaction site; other site 365046012171 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 365046012172 putative RNAase interaction site [polypeptide binding]; other site 365046012173 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 365046012174 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 365046012175 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 365046012176 SurA N-terminal domain; Region: SurA_N; pfam09312 365046012177 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 365046012178 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 365046012179 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 365046012180 Organic solvent tolerance protein; Region: OstA_C; pfam04453 365046012181 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 365046012182 Phosphotransferase enzyme family; Region: APH; pfam01636 365046012183 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 365046012184 RNA methyltransferase, RsmE family; Region: TIGR00046 365046012185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 365046012186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 365046012187 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 365046012188 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 365046012189 hypothetical protein; Provisional; Region: PRK07907 365046012190 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 365046012191 metal binding site [ion binding]; metal-binding site 365046012192 putative dimer interface [polypeptide binding]; other site 365046012193 Protein of unknown function DUF72; Region: DUF72; pfam01904 365046012194 Protein of unknown function DUF72; Region: DUF72; cl00777 365046012195 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 365046012196 Predicted membrane protein [Function unknown]; Region: COG2323 365046012197 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 365046012198 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 365046012199 intersubunit interface [polypeptide binding]; other site 365046012200 active site 365046012201 Zn2+ binding site [ion binding]; other site 365046012202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 365046012203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046012204 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 365046012205 NAD(P) binding site [chemical binding]; other site 365046012206 active site 365046012207 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 365046012208 Chromate transporter; Region: Chromate_transp; pfam02417 365046012209 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 365046012210 active site residue [active] 365046012211 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 365046012212 Methyltransferase domain; Region: Methyltransf_23; pfam13489 365046012213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 365046012214 S-adenosylmethionine binding site [chemical binding]; other site 365046012215 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 365046012216 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 365046012217 Predicted membrane protein [Function unknown]; Region: COG2119 365046012218 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 365046012219 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 365046012220 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 365046012221 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 365046012222 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 365046012223 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 365046012224 UbiA prenyltransferase family; Region: UbiA; pfam01040 365046012225 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 365046012226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046012227 motif II; other site 365046012228 Predicted membrane protein [Function unknown]; Region: COG2246 365046012229 GtrA-like protein; Region: GtrA; pfam04138 365046012230 short chain dehydrogenase; Provisional; Region: PRK07024 365046012231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 365046012232 NAD(P) binding site [chemical binding]; other site 365046012233 active site 365046012234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 365046012235 active site 365046012236 motif I; other site 365046012237 motif II; other site 365046012238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 365046012239 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 365046012240 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 365046012241 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 365046012242 putative active site [active] 365046012243 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 365046012244 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 365046012245 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 365046012246 TrkA-N domain; Region: TrkA_N; pfam02254 365046012247 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 365046012248 ligand binding site [chemical binding]; other site 365046012249 flexible hinge region; other site 365046012250 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 365046012251 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 365046012252 trmE is a tRNA modification GTPase; Region: trmE; cd04164 365046012253 G1 box; other site 365046012254 GTP/Mg2+ binding site [chemical binding]; other site 365046012255 Switch I region; other site 365046012256 G2 box; other site 365046012257 Switch II region; other site 365046012258 G3 box; other site 365046012259 G4 box; other site 365046012260 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 365046012261 membrane protein insertase; Provisional; Region: PRK01318 365046012262 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 365046012263 Haemolytic domain; Region: Haemolytic; cl00506 365046012264 RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594 365046012265 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399