-- dump date 20140619_223552 -- class Genbank::misc_feature -- table misc_feature_note -- id note 670487000001 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 670487000002 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 670487000003 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 670487000004 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 670487000005 CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485 670487000006 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 670487000007 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 670487000008 trimer interface [polypeptide binding]; other site 670487000009 active site 670487000010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 670487000011 nucleotide binding region [chemical binding]; other site 670487000012 ATP-binding site [chemical binding]; other site 670487000013 Methyltransferase domain; Region: Methyltransf_26; pfam13659 670487000014 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 670487000015 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 670487000016 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 670487000017 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 670487000018 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 670487000019 TSCPD domain; Region: TSCPD; pfam12637 670487000020 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 670487000021 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 670487000022 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 670487000023 3D domain; Region: 3D; cl01439 670487000024 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 670487000025 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 670487000026 metal ion-dependent adhesion site (MIDAS); other site 670487000027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487000028 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 670487000029 Walker A motif; other site 670487000030 ATP binding site [chemical binding]; other site 670487000031 Walker B motif; other site 670487000032 arginine finger; other site 670487000033 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 670487000034 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 670487000035 ADP-ribose binding site [chemical binding]; other site 670487000036 DNA polymerase III subunit beta; Provisional; Region: PRK14945 670487000037 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 670487000038 putative DNA binding surface [nucleotide binding]; other site 670487000039 dimer interface [polypeptide binding]; other site 670487000040 beta-clamp/clamp loader binding surface; other site 670487000041 beta-clamp/translesion DNA polymerase binding surface; other site 670487000042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 670487000043 DdrB-like protein; Region: DdrB; pfam12747 670487000044 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 670487000045 Divergent AAA domain; Region: AAA_4; pfam04326 670487000046 Divergent AAA domain; Region: AAA_4; pfam04326 670487000047 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 670487000048 RES domain; Region: RES; smart00953 670487000049 FUN14 family; Region: FUN14; pfam04930 670487000050 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 670487000051 Part of AAA domain; Region: AAA_19; pfam13245 670487000052 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 670487000053 Family description; Region: UvrD_C_2; pfam13538 670487000054 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 670487000055 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 670487000056 AAA domain; Region: AAA_22; pfam13401 670487000057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 670487000058 Walker A/P-loop; other site 670487000059 ATP binding site [chemical binding]; other site 670487000060 ABC transporter signature motif; other site 670487000061 Walker B; other site 670487000062 D-loop; other site 670487000063 Family description; Region: UvrD_C_2; pfam13538 670487000064 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 670487000065 toxin interface [polypeptide binding]; other site 670487000066 Zn binding site [ion binding]; other site 670487000067 ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: ClpX; COG1219 670487000068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487000069 Walker A motif; other site 670487000070 ATP binding site [chemical binding]; other site 670487000071 Walker B motif; other site 670487000072 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 670487000073 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 670487000074 Walker A motif; other site 670487000075 ATP binding site [chemical binding]; other site 670487000076 Walker B motif; other site 670487000077 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 670487000078 Family description; Region: UvrD_C_2; pfam13538 670487000079 S-layer homology domain; Region: SLH; pfam00395 670487000080 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 670487000081 linker region; other site 670487000082 ParB-like nuclease domain; Region: ParBc; pfam02195 670487000083 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 670487000084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 670487000085 Magnesium ion binding site [ion binding]; other site 670487000086 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 670487000087 dimer interface [polypeptide binding]; other site 670487000088 ssDNA binding site [nucleotide binding]; other site 670487000089 tetramer (dimer of dimers) interface [polypeptide binding]; other site 670487000090 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 670487000091 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 670487000092 dimer interface [polypeptide binding]; other site 670487000093 ssDNA binding site [nucleotide binding]; other site 670487000094 tetramer (dimer of dimers) interface [polypeptide binding]; other site 670487000095 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 670487000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487000097 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 670487000098 Walker A motif; other site 670487000099 ATP binding site [chemical binding]; other site 670487000100 Walker B motif; other site 670487000101 arginine finger; other site 670487000102 ParB-like nuclease domain; Region: ParBc; pfam02195 670487000103 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 670487000104 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 670487000105 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 670487000106 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 670487000107 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 670487000108 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 670487000109 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 670487000110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487000111 Walker A motif; other site 670487000112 ATP binding site [chemical binding]; other site 670487000113 Walker B motif; other site 670487000114 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 670487000115 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 670487000116 N-acetyl-D-glucosamine binding site [chemical binding]; other site 670487000117 catalytic residue [active] 670487000118 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 670487000119 Walker A motif; other site 670487000120 ATP binding site [chemical binding]; other site 670487000121 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 670487000122 Walker B motif; other site 670487000123 AAA-like domain; Region: AAA_10; pfam12846 670487000124 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 670487000125 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 670487000126 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 670487000127 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 670487000128 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 670487000129 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 670487000130 Archaebacterial flagellin; Region: Arch_flagellin; cl00732 670487000131 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 670487000132 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 670487000133 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 670487000134 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 670487000135 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 670487000136 Walker A motif; other site 670487000137 ATP binding site [chemical binding]; other site 670487000138 Walker B motif; other site 670487000139 Uncharacterized conserved protein [Function unknown]; Region: COG4983 670487000140 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 670487000141 Staphylococcal nuclease homologues; Region: SNc; smart00318 670487000142 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 670487000143 Catalytic site; other site 670487000144 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 670487000145 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 670487000146 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 670487000147 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 670487000148 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 670487000149 active site 670487000150 DNA binding site [nucleotide binding] 670487000151 Int/Topo IB signature motif; other site 670487000152 Protein of unknown function DUF72; Region: DUF72; pfam01904 670487000153 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 670487000154 DnaA N-terminal domain; Region: DnaA_N; pfam11638 670487000155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487000156 Walker A motif; other site 670487000157 ATP binding site [chemical binding]; other site 670487000158 Walker B motif; other site 670487000159 arginine finger; other site 670487000160 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 670487000161 metal binding site [ion binding]; metal-binding site 670487000162 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 670487000163 DnaA box-binding interface [nucleotide binding]; other site 670487000164 DNA polymerase III subunit beta; Provisional; Region: PRK14945 670487000165 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 670487000166 putative DNA binding surface [nucleotide binding]; other site 670487000167 dimer interface [polypeptide binding]; other site 670487000168 beta-clamp/clamp loader binding surface; other site 670487000169 beta-clamp/translesion DNA polymerase binding surface; other site 670487000170 enolase; Provisional; Region: eno; PRK00077 670487000171 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 670487000172 dimer interface [polypeptide binding]; other site 670487000173 metal binding site [ion binding]; metal-binding site 670487000174 substrate binding pocket [chemical binding]; other site 670487000175 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 670487000176 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 670487000177 domain interfaces; other site 670487000178 active site 670487000179 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 670487000180 metal ion-dependent adhesion site (MIDAS); other site 670487000181 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 670487000182 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 670487000183 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 670487000184 homotrimer interaction site [polypeptide binding]; other site 670487000185 zinc binding site [ion binding]; other site 670487000186 CDP-binding sites; other site 670487000187 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 670487000188 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 670487000189 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 670487000190 putative di-iron ligands [ion binding]; other site 670487000191 UPF0126 domain; Region: UPF0126; pfam03458 670487000192 Predicted membrane protein [Function unknown]; Region: COG2860 670487000193 UPF0126 domain; Region: UPF0126; pfam03458 670487000194 short chain dehydrogenase; Provisional; Region: PRK07326 670487000195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487000196 NAD(P) binding site [chemical binding]; other site 670487000197 active site 670487000198 Cupin domain; Region: Cupin_2; pfam07883 670487000199 hypothetical protein; Provisional; Region: PRK07338 670487000200 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 670487000201 metal binding site [ion binding]; metal-binding site 670487000202 dimer interface [polypeptide binding]; other site 670487000203 carboxylate-amine ligase; Provisional; Region: PRK13515 670487000204 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 670487000205 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 670487000206 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 670487000207 GDP-binding site [chemical binding]; other site 670487000208 ACT binding site; other site 670487000209 IMP binding site; other site 670487000210 histidinol-phosphatase; Provisional; Region: PRK07328 670487000211 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 670487000212 active site 670487000213 dimer interface [polypeptide binding]; other site 670487000214 hypothetical protein; Provisional; Region: PRK08609 670487000215 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 670487000216 metal binding triad [ion binding]; metal-binding site 670487000217 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 670487000218 active site 670487000219 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 670487000220 TrkA-N domain; Region: TrkA_N; pfam02254 670487000221 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 670487000222 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 670487000223 nucleotide binding site [chemical binding]; other site 670487000224 N-acetyl-L-glutamate binding site [chemical binding]; other site 670487000225 EamA-like transporter family; Region: EamA; pfam00892 670487000226 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 670487000227 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 670487000228 Asparaginase; Region: Asparaginase; pfam00710 670487000229 active site 670487000230 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 670487000231 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 670487000232 metal-binding site [ion binding] 670487000233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 670487000234 Soluble P-type ATPase [General function prediction only]; Region: COG4087 670487000235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 670487000236 dimerization interface [polypeptide binding]; other site 670487000237 putative DNA binding site [nucleotide binding]; other site 670487000238 putative Zn2+ binding site [ion binding]; other site 670487000239 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 670487000240 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 670487000241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487000242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487000243 active site 670487000244 phosphorylation site [posttranslational modification] 670487000245 intermolecular recognition site; other site 670487000246 dimerization interface [polypeptide binding]; other site 670487000247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487000248 DNA binding site [nucleotide binding] 670487000249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487000250 dimer interface [polypeptide binding]; other site 670487000251 phosphorylation site [posttranslational modification] 670487000252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487000253 ATP binding site [chemical binding]; other site 670487000254 Mg2+ binding site [ion binding]; other site 670487000255 G-X-G motif; other site 670487000256 Spondin_N; Region: Spond_N; pfam06468 670487000257 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 670487000258 active site 670487000259 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 670487000260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 670487000261 DNA binding residues [nucleotide binding] 670487000262 dimerization interface [polypeptide binding]; other site 670487000263 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 670487000264 manganese transport protein MntH; Reviewed; Region: PRK00701 670487000265 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 670487000266 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 670487000267 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 670487000268 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 670487000269 FeoA domain; Region: FeoA; pfam04023 670487000270 peptide chain release factor 1; Validated; Region: prfA; PRK00591 670487000271 This domain is found in peptide chain release factors; Region: PCRF; smart00937 670487000272 RF-1 domain; Region: RF-1; pfam00472 670487000273 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 670487000274 nudix motif; other site 670487000275 glycogen synthase; Provisional; Region: glgA; PRK00654 670487000276 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 670487000277 ADP-binding pocket [chemical binding]; other site 670487000278 homodimer interface [polypeptide binding]; other site 670487000279 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 670487000280 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 670487000281 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 670487000282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 670487000283 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 670487000284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 670487000285 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 670487000286 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 670487000287 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 670487000288 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 670487000289 FMN binding site [chemical binding]; other site 670487000290 active site 670487000291 catalytic residues [active] 670487000292 substrate binding site [chemical binding]; other site 670487000293 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 670487000294 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 670487000295 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 670487000296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487000297 S-adenosylmethionine binding site [chemical binding]; other site 670487000298 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 670487000299 DNA protecting protein DprA; Region: dprA; TIGR00732 670487000300 Domain of unknown function (DUF389); Region: DUF389; pfam04087 670487000301 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 670487000302 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 670487000303 active site 670487000304 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 670487000305 Protein of unknown function, DUF606; Region: DUF606; pfam04657 670487000306 Putative Ig domain; Region: He_PIG; pfam05345 670487000307 Dockerin type I repeat; Region: Dockerin_1; pfam00404 670487000308 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 670487000309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487000310 active site 670487000311 motif I; other site 670487000312 motif II; other site 670487000313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487000314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487000315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487000316 dimer interface [polypeptide binding]; other site 670487000317 conserved gate region; other site 670487000318 putative PBP binding loops; other site 670487000319 ABC-ATPase subunit interface; other site 670487000320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 670487000321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487000322 ABC-ATPase subunit interface; other site 670487000323 putative PBP binding loops; other site 670487000324 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 670487000325 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 670487000326 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 670487000327 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 670487000328 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 670487000329 Protein of unknown function DUF86; Region: DUF86; cl01031 670487000330 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 670487000331 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 670487000332 nucleotide binding site [chemical binding]; other site 670487000333 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 670487000334 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 670487000335 RNA binding site [nucleotide binding]; other site 670487000336 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 670487000337 RNA binding site [nucleotide binding]; other site 670487000338 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 670487000339 RNA binding site [nucleotide binding]; other site 670487000340 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 670487000341 RNA binding site [nucleotide binding]; other site 670487000342 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 670487000343 RNA binding site [nucleotide binding]; other site 670487000344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 670487000345 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 670487000346 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 670487000347 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 670487000348 G1 box; other site 670487000349 putative GEF interaction site [polypeptide binding]; other site 670487000350 GTP/Mg2+ binding site [chemical binding]; other site 670487000351 Switch I region; other site 670487000352 G2 box; other site 670487000353 G3 box; other site 670487000354 Switch II region; other site 670487000355 G4 box; other site 670487000356 G5 box; other site 670487000357 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 670487000358 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 670487000359 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 670487000360 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 670487000361 cofactor binding site; other site 670487000362 DNA binding site [nucleotide binding] 670487000363 substrate interaction site [chemical binding]; other site 670487000364 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 670487000365 endonuclease III; Region: ENDO3c; smart00478 670487000366 minor groove reading motif; other site 670487000367 helix-hairpin-helix signature motif; other site 670487000368 substrate binding pocket [chemical binding]; other site 670487000369 active site 670487000370 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 670487000371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 670487000372 ATP-binding site [chemical binding]; other site 670487000373 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 670487000374 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 670487000375 PLD-like domain; Region: PLDc_2; pfam13091 670487000376 putative active site [active] 670487000377 catalytic site [active] 670487000378 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 670487000379 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 670487000380 TIGR03987 family protein; Region: TIGR03987 670487000381 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 670487000382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487000383 putative PBP binding loops; other site 670487000384 ABC-ATPase subunit interface; other site 670487000385 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487000386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487000387 ABC-ATPase subunit interface; other site 670487000388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 670487000389 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 670487000390 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 670487000391 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 670487000392 Metal-binding active site; metal-binding site 670487000393 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487000394 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 670487000395 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487000396 Cytochrome c; Region: Cytochrom_C; pfam00034 670487000397 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 670487000398 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 670487000399 iron-sulfur cluster [ion binding]; other site 670487000400 [2Fe-2S] cluster binding site [ion binding]; other site 670487000401 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 670487000402 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 670487000403 heme bH binding site [chemical binding]; other site 670487000404 Qi binding site; other site 670487000405 intrachain domain interface; other site 670487000406 heme bL binding site [chemical binding]; other site 670487000407 interchain domain interface [polypeptide binding]; other site 670487000408 Qo binding site; other site 670487000409 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 670487000410 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 670487000411 active site 670487000412 Zn binding site [ion binding]; other site 670487000413 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 670487000414 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 670487000415 GatB domain; Region: GatB_Yqey; smart00845 670487000416 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 670487000417 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 670487000418 active site 670487000419 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 670487000420 oligomer interface [polypeptide binding]; other site 670487000421 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 670487000422 GAF domain; Region: GAF; pfam01590 670487000423 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 670487000424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 670487000425 putative active site [active] 670487000426 heme pocket [chemical binding]; other site 670487000427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 670487000428 putative active site [active] 670487000429 heme pocket [chemical binding]; other site 670487000430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487000431 metal binding site [ion binding]; metal-binding site 670487000432 active site 670487000433 I-site; other site 670487000434 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 670487000435 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487000436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487000437 metal binding site [ion binding]; metal-binding site 670487000438 active site 670487000439 I-site; other site 670487000440 Sulfatase; Region: Sulfatase; cl17466 670487000441 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 670487000442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487000443 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 670487000444 Walker A/P-loop; other site 670487000445 ATP binding site [chemical binding]; other site 670487000446 Q-loop/lid; other site 670487000447 ABC transporter signature motif; other site 670487000448 Walker B; other site 670487000449 D-loop; other site 670487000450 H-loop/switch region; other site 670487000451 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 670487000452 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 670487000453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487000454 Zn2+ binding site [ion binding]; other site 670487000455 Mg2+ binding site [ion binding]; other site 670487000456 recombinase A; Provisional; Region: recA; PRK09354 670487000457 recA bacterial DNA recombination protein; Region: RecA; cl17211 670487000458 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 670487000459 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 670487000460 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 670487000461 competence damage-inducible protein A; Provisional; Region: PRK00549 670487000462 putative MPT binding site; other site 670487000463 Competence-damaged protein; Region: CinA; pfam02464 670487000464 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 670487000465 active site 670487000466 dimer interfaces [polypeptide binding]; other site 670487000467 catalytic residues [active] 670487000468 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 670487000469 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 670487000470 oligomer interface [polypeptide binding]; other site 670487000471 active site 670487000472 metal binding site [ion binding]; metal-binding site 670487000473 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 670487000474 homodimer interface [polypeptide binding]; other site 670487000475 metal binding site [ion binding]; metal-binding site 670487000476 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 670487000477 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 670487000478 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 670487000479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487000480 active site 670487000481 motif I; other site 670487000482 motif II; other site 670487000483 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 670487000484 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 670487000485 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 670487000486 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 670487000487 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 670487000488 Walker A motif; other site 670487000489 ATP binding site [chemical binding]; other site 670487000490 Walker B motif; other site 670487000491 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 670487000492 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 670487000493 Walker A motif; other site 670487000494 ATP binding site [chemical binding]; other site 670487000495 Walker B motif; other site 670487000496 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 670487000497 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 670487000498 Walker A/P-loop; other site 670487000499 ATP binding site [chemical binding]; other site 670487000500 Q-loop/lid; other site 670487000501 ABC transporter signature motif; other site 670487000502 Walker B; other site 670487000503 D-loop; other site 670487000504 H-loop/switch region; other site 670487000505 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 670487000506 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 670487000507 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487000508 TM-ABC transporter signature motif; other site 670487000509 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 670487000510 TM-ABC transporter signature motif; other site 670487000511 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 670487000512 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 670487000513 putative ligand binding site [chemical binding]; other site 670487000514 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 670487000515 Low molecular weight phosphatase family; Region: LMWPc; cl00105 670487000516 active site 670487000517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 670487000518 TPR motif; other site 670487000519 binding surface 670487000520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487000521 binding surface 670487000522 TPR motif; other site 670487000523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487000524 TPR motif; other site 670487000525 binding surface 670487000526 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 670487000527 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 670487000528 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 670487000529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487000530 Zn2+ binding site [ion binding]; other site 670487000531 Mg2+ binding site [ion binding]; other site 670487000532 Response regulator receiver domain; Region: Response_reg; pfam00072 670487000533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487000534 active site 670487000535 phosphorylation site [posttranslational modification] 670487000536 intermolecular recognition site; other site 670487000537 dimerization interface [polypeptide binding]; other site 670487000538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487000539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 670487000540 dimer interface [polypeptide binding]; other site 670487000541 phosphorylation site [posttranslational modification] 670487000542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487000543 ATP binding site [chemical binding]; other site 670487000544 Mg2+ binding site [ion binding]; other site 670487000545 G-X-G motif; other site 670487000546 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 670487000547 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 670487000548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 670487000549 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 670487000550 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 670487000551 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 670487000552 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 670487000553 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 670487000554 active site 670487000555 dimer interface [polypeptide binding]; other site 670487000556 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 670487000557 dimer interface [polypeptide binding]; other site 670487000558 active site 670487000559 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 670487000560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487000561 Walker A/P-loop; other site 670487000562 ATP binding site [chemical binding]; other site 670487000563 Q-loop/lid; other site 670487000564 ABC transporter signature motif; other site 670487000565 Walker B; other site 670487000566 D-loop; other site 670487000567 H-loop/switch region; other site 670487000568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 670487000569 DNA-binding site [nucleotide binding]; DNA binding site 670487000570 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 670487000571 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 670487000572 Peptidase family M48; Region: Peptidase_M48; cl12018 670487000573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487000574 S-adenosylmethionine binding site [chemical binding]; other site 670487000575 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 670487000576 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 670487000577 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 670487000578 Amidase; Region: Amidase; cl11426 670487000579 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 670487000580 putative metal binding site [ion binding]; other site 670487000581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487000582 S-adenosylmethionine binding site [chemical binding]; other site 670487000583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 670487000584 PAS domain; Region: PAS_9; pfam13426 670487000585 putative active site [active] 670487000586 heme pocket [chemical binding]; other site 670487000587 PAS domain; Region: PAS; smart00091 670487000588 PAS domain S-box; Region: sensory_box; TIGR00229 670487000589 PAS domain S-box; Region: sensory_box; TIGR00229 670487000590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 670487000591 putative active site [active] 670487000592 heme pocket [chemical binding]; other site 670487000593 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487000594 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487000595 metal binding site [ion binding]; metal-binding site 670487000596 active site 670487000597 I-site; other site 670487000598 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 670487000599 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487000600 Cytochrome c; Region: Cytochrom_C; pfam00034 670487000601 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487000602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487000603 active site 670487000604 phosphorylation site [posttranslational modification] 670487000605 intermolecular recognition site; other site 670487000606 dimerization interface [polypeptide binding]; other site 670487000607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487000608 DNA binding site [nucleotide binding] 670487000609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 670487000610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487000611 dimer interface [polypeptide binding]; other site 670487000612 phosphorylation site [posttranslational modification] 670487000613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487000614 ATP binding site [chemical binding]; other site 670487000615 G-X-G motif; other site 670487000616 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487000617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487000618 active site 670487000619 phosphorylation site [posttranslational modification] 670487000620 intermolecular recognition site; other site 670487000621 dimerization interface [polypeptide binding]; other site 670487000622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487000623 DNA binding site [nucleotide binding] 670487000624 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 670487000625 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 670487000626 G1 box; other site 670487000627 GTP/Mg2+ binding site [chemical binding]; other site 670487000628 G2 box; other site 670487000629 Switch I region; other site 670487000630 G3 box; other site 670487000631 Switch II region; other site 670487000632 G4 box; other site 670487000633 G5 box; other site 670487000634 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 670487000635 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 670487000636 heme-binding site [chemical binding]; other site 670487000637 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 670487000638 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 670487000639 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 670487000640 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 670487000641 Walker A/P-loop; other site 670487000642 ATP binding site [chemical binding]; other site 670487000643 Q-loop/lid; other site 670487000644 ABC transporter signature motif; other site 670487000645 Walker B; other site 670487000646 D-loop; other site 670487000647 H-loop/switch region; other site 670487000648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 670487000649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 670487000650 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 670487000651 YwiC-like protein; Region: YwiC; pfam14256 670487000652 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 670487000653 Ligand Binding Site [chemical binding]; other site 670487000654 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 670487000655 Ligand Binding Site [chemical binding]; other site 670487000656 SurA N-terminal domain; Region: SurA_N_3; cl07813 670487000657 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 670487000658 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 670487000659 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 670487000660 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 670487000661 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 670487000662 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 670487000663 intersubunit interface [polypeptide binding]; other site 670487000664 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 670487000665 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 670487000666 active site 670487000667 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 670487000668 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 670487000669 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 670487000670 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 670487000671 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 670487000672 Cysteine-rich domain; Region: CCG; pfam02754 670487000673 Cysteine-rich domain; Region: CCG; pfam02754 670487000674 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 670487000675 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 670487000676 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 670487000677 TrkA-C domain; Region: TrkA_C; pfam02080 670487000678 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 670487000679 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 670487000680 putative RNA binding site [nucleotide binding]; other site 670487000681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487000682 S-adenosylmethionine binding site [chemical binding]; other site 670487000683 spermine synthase; Region: PLN02823 670487000684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487000685 S-adenosylmethionine binding site [chemical binding]; other site 670487000686 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 670487000687 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 670487000688 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 670487000689 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 670487000690 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 670487000691 dimer interface [polypeptide binding]; other site 670487000692 ssDNA binding site [nucleotide binding]; other site 670487000693 tetramer (dimer of dimers) interface [polypeptide binding]; other site 670487000694 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 670487000695 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 670487000696 dimer interface [polypeptide binding]; other site 670487000697 ssDNA binding site [nucleotide binding]; other site 670487000698 tetramer (dimer of dimers) interface [polypeptide binding]; other site 670487000699 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 670487000700 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 670487000701 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 670487000702 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 670487000703 FOG: PKD repeat [General function prediction only]; Region: COG3291 670487000704 PKD domain; Region: PKD; pfam00801 670487000705 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 670487000706 PKD domain; Region: PKD; pfam00801 670487000707 FOG: PKD repeat [General function prediction only]; Region: COG3291 670487000708 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 670487000709 surface protease GP63; Provisional; Region: PTZ00337 670487000710 replicative DNA helicase; Region: DnaB; TIGR00665 670487000711 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 670487000712 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 670487000713 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 670487000714 Walker A motif; other site 670487000715 Walker A motif; other site 670487000716 ATP binding site [chemical binding]; other site 670487000717 Walker B motif; other site 670487000718 DNA binding loops [nucleotide binding] 670487000719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 670487000720 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 670487000721 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 670487000722 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 670487000723 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 670487000724 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 670487000725 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 670487000726 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 670487000727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 670487000728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 670487000729 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 670487000730 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 670487000731 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 670487000732 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 670487000733 putative [4Fe-4S] binding site [ion binding]; other site 670487000734 putative molybdopterin cofactor binding site [chemical binding]; other site 670487000735 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 670487000736 molybdopterin cofactor binding site; other site 670487000737 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 670487000738 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 670487000739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487000740 NAD(P) binding site [chemical binding]; other site 670487000741 active site 670487000742 peptide chain release factor 2; Validated; Region: prfB; PRK00578 670487000743 This domain is found in peptide chain release factors; Region: PCRF; smart00937 670487000744 RF-1 domain; Region: RF-1; pfam00472 670487000745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487000746 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 670487000747 Walker A/P-loop; other site 670487000748 ATP binding site [chemical binding]; other site 670487000749 Q-loop/lid; other site 670487000750 ABC transporter signature motif; other site 670487000751 Walker B; other site 670487000752 D-loop; other site 670487000753 H-loop/switch region; other site 670487000754 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 670487000755 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 670487000756 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 670487000757 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 670487000758 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 670487000759 DctM-like transporters; Region: DctM; pfam06808 670487000760 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 670487000761 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 670487000762 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 670487000763 DTAP/Switch II; other site 670487000764 Switch I; other site 670487000765 Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953 670487000766 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 670487000767 catalytic core [active] 670487000768 Amidase; Region: Amidase; cl11426 670487000769 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 670487000770 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 670487000771 tetramer interface [polypeptide binding]; other site 670487000772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487000773 catalytic residue [active] 670487000774 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 670487000775 MPT binding site; other site 670487000776 trimer interface [polypeptide binding]; other site 670487000777 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 670487000778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 670487000779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487000780 homodimer interface [polypeptide binding]; other site 670487000781 catalytic residue [active] 670487000782 Ion channel; Region: Ion_trans_2; pfam07885 670487000783 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 670487000784 TrkA-N domain; Region: TrkA_N; pfam02254 670487000785 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 670487000786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487000787 FeS/SAM binding site; other site 670487000788 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 670487000789 GTPase Era; Reviewed; Region: era; PRK00089 670487000790 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 670487000791 G1 box; other site 670487000792 GTP/Mg2+ binding site [chemical binding]; other site 670487000793 Switch I region; other site 670487000794 G2 box; other site 670487000795 Switch II region; other site 670487000796 G3 box; other site 670487000797 G4 box; other site 670487000798 G5 box; other site 670487000799 KH domain; Region: KH_2; pfam07650 670487000800 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 670487000801 VanW like protein; Region: VanW; pfam04294 670487000802 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 670487000803 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 670487000804 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 670487000805 dinuclear metal binding motif [ion binding]; other site 670487000806 peptide chain release factor 1; Provisional; Region: PRK04011 670487000807 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 670487000808 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 670487000809 putative dimer interface [polypeptide binding]; other site 670487000810 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 670487000811 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 670487000812 putative homodimer interface [polypeptide binding]; other site 670487000813 putative homotetramer interface [polypeptide binding]; other site 670487000814 putative allosteric switch controlling residues; other site 670487000815 putative metal binding site [ion binding]; other site 670487000816 putative homodimer-homodimer interface [polypeptide binding]; other site 670487000817 Protein of unknown function DUF72; Region: DUF72; pfam01904 670487000818 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 670487000819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487000820 motif II; other site 670487000821 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 670487000822 active site 670487000823 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 670487000824 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 670487000825 active site 670487000826 metal binding site [ion binding]; metal-binding site 670487000827 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 670487000828 trimer interface [polypeptide binding]; other site 670487000829 active site 670487000830 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 670487000831 Uncharacterized conserved protein [Function unknown]; Region: COG1543 670487000832 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 670487000833 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 670487000834 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 670487000835 putative ligand binding site [chemical binding]; other site 670487000836 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 670487000837 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 670487000838 phosphate binding site [ion binding]; other site 670487000839 putative substrate binding pocket [chemical binding]; other site 670487000840 dimer interface [polypeptide binding]; other site 670487000841 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 670487000842 AAA domain; Region: AAA_18; pfam13238 670487000843 Predicted membrane protein [Function unknown]; Region: COG3431 670487000844 Uncharacterized conserved protein [Function unknown]; Region: COG1542 670487000845 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 670487000846 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 670487000847 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 670487000848 active site 670487000849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 670487000850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487000851 putative substrate translocation pore; other site 670487000852 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 670487000853 putative catalytic site [active] 670487000854 putative metal binding site [ion binding]; other site 670487000855 putative catalytic site [active] 670487000856 putative phosphate binding site [ion binding]; other site 670487000857 putative phosphate binding site [ion binding]; other site 670487000858 putative metal binding site [ion binding]; other site 670487000859 prolyl-tRNA synthetase; Provisional; Region: PRK08661 670487000860 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 670487000861 dimer interface [polypeptide binding]; other site 670487000862 motif 1; other site 670487000863 active site 670487000864 motif 2; other site 670487000865 motif 3; other site 670487000866 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 670487000867 anticodon binding site; other site 670487000868 zinc-binding site [ion binding]; other site 670487000869 ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401 670487000870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 670487000871 Walker A/P-loop; other site 670487000872 ATP binding site [chemical binding]; other site 670487000873 Q-loop/lid; other site 670487000874 ABC transporter signature motif; other site 670487000875 Walker B; other site 670487000876 D-loop; other site 670487000877 H-loop/switch region; other site 670487000878 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 670487000879 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 670487000880 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 670487000881 minor groove reading motif; other site 670487000882 helix-hairpin-helix signature motif; other site 670487000883 substrate binding pocket [chemical binding]; other site 670487000884 active site 670487000885 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 670487000886 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 670487000887 Putative zinc ribbon domain; Region: DUF164; pfam02591 670487000888 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 670487000889 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 670487000890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487000891 binding surface 670487000892 TPR motif; other site 670487000893 Tetratricopeptide repeat; Region: TPR_12; pfam13424 670487000894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 670487000895 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 670487000896 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 670487000897 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 670487000898 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 670487000899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487000900 motif II; other site 670487000901 Protein of unknown function (DUF3208); Region: DUF3208; pfam11482 670487000902 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 670487000903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487000904 FeS/SAM binding site; other site 670487000905 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 670487000906 Caa3-Type Cytochrome Oxidase subunit 4 interacts with cyt c subunits I/III; Region: Caa3-IV; cd12222 670487000907 dimer interface [polypeptide binding]; other site 670487000908 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 670487000909 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 670487000910 active site 670487000911 metal binding site [ion binding]; metal-binding site 670487000912 AAA ATPase domain; Region: AAA_16; pfam13191 670487000913 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 670487000914 DNA polymerase III subunit delta'; Validated; Region: PRK08485 670487000915 PSP1 C-terminal conserved region; Region: PSP1; cl00770 670487000916 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 670487000917 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487000918 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 670487000919 TM-ABC transporter signature motif; other site 670487000920 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 670487000921 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487000922 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 670487000923 TM-ABC transporter signature motif; other site 670487000924 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 670487000925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487000926 S-adenosylmethionine binding site [chemical binding]; other site 670487000927 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 670487000928 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 670487000929 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 670487000930 minor groove reading motif; other site 670487000931 helix-hairpin-helix signature motif; other site 670487000932 substrate binding pocket [chemical binding]; other site 670487000933 active site 670487000934 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 670487000935 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 670487000936 DNA binding and oxoG recognition site [nucleotide binding] 670487000937 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 670487000938 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 670487000939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487000940 active site 670487000941 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 670487000942 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 670487000943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 670487000944 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 670487000945 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 670487000946 ligand binding site [chemical binding]; other site 670487000947 flexible hinge region; other site 670487000948 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 670487000949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 670487000950 Stage II sporulation protein; Region: SpoIID; pfam08486 670487000951 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 670487000952 Uncharacterized conserved protein [Function unknown]; Region: COG1432 670487000953 LabA_like proteins; Region: LabA_like/DUF88; cl10034 670487000954 putative metal binding site [ion binding]; other site 670487000955 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487000956 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 670487000957 DEAD-like helicases superfamily; Region: DEXDc; smart00487 670487000958 ATP binding site [chemical binding]; other site 670487000959 Mg++ binding site [ion binding]; other site 670487000960 motif III; other site 670487000961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 670487000962 nucleotide binding region [chemical binding]; other site 670487000963 ATP-binding site [chemical binding]; other site 670487000964 RNA-binding GUCT-like domain found in Thermus thermophilus heat resistant RNA-dependent ATPase (Hera) and similar proteins; Region: GUCT_Hera; cd12938 670487000965 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 670487000966 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 670487000967 glutaminase active site [active] 670487000968 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 670487000969 dimer interface [polypeptide binding]; other site 670487000970 active site 670487000971 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 670487000972 dimer interface [polypeptide binding]; other site 670487000973 active site 670487000974 S-layer homology domain; Region: SLH; pfam00395 670487000975 Gram-negative porin; Region: Porin_4; pfam13609 670487000976 excinuclease ABC subunit B; Provisional; Region: PRK05298 670487000977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 670487000978 ATP binding site [chemical binding]; other site 670487000979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 670487000980 nucleotide binding region [chemical binding]; other site 670487000981 ATP-binding site [chemical binding]; other site 670487000982 Ultra-violet resistance protein B; Region: UvrB; pfam12344 670487000983 UvrB/uvrC motif; Region: UVR; pfam02151 670487000984 e3 binding domain; Region: E3_binding; pfam02817 670487000985 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 670487000986 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 670487000987 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 670487000988 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 670487000989 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 670487000990 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 670487000991 NlpC/P60 family; Region: NLPC_P60; pfam00877 670487000992 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 670487000993 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 670487000994 FOG: CBS domain [General function prediction only]; Region: COG0517 670487000995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 670487000996 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 670487000997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487000998 S-adenosylmethionine binding site [chemical binding]; other site 670487000999 hypothetical protein; Provisional; Region: PRK09272 670487001000 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 670487001001 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 670487001002 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 670487001003 calcium binding site 2 [ion binding]; other site 670487001004 active site 670487001005 catalytic triad [active] 670487001006 calcium binding site 1 [ion binding]; other site 670487001007 Right handed beta helix region; Region: Beta_helix; pfam13229 670487001008 Right handed beta helix region; Region: Beta_helix; pfam13229 670487001009 Right handed beta helix region; Region: Beta_helix; pfam13229 670487001010 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 670487001011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 670487001012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 670487001013 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 670487001014 proposed catalytic triad [active] 670487001015 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 670487001016 putative active site pocket [active] 670487001017 cleavage site 670487001018 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 670487001019 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 670487001020 MoaE interaction surface [polypeptide binding]; other site 670487001021 MoeB interaction surface [polypeptide binding]; other site 670487001022 thiocarboxylated glycine; other site 670487001023 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 670487001024 MoaE homodimer interface [polypeptide binding]; other site 670487001025 MoaD interaction [polypeptide binding]; other site 670487001026 active site residues [active] 670487001027 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 670487001028 HTH domain; Region: HTH_11; pfam08279 670487001029 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 670487001030 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 670487001031 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 670487001032 Divergent AAA domain; Region: AAA_4; pfam04326 670487001033 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 670487001034 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 670487001035 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 670487001036 Nitrogen regulatory protein P-II; Region: P-II; smart00938 670487001037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 670487001038 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 670487001039 NAD synthetase; Provisional; Region: PRK13980 670487001040 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 670487001041 homodimer interface [polypeptide binding]; other site 670487001042 NAD binding pocket [chemical binding]; other site 670487001043 ATP binding pocket [chemical binding]; other site 670487001044 Mg binding site [ion binding]; other site 670487001045 active-site loop [active] 670487001046 Predicted amidohydrolase [General function prediction only]; Region: COG0388 670487001047 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 670487001048 active site 670487001049 catalytic triad [active] 670487001050 dimer interface [polypeptide binding]; other site 670487001051 FOG: CBS domain [General function prediction only]; Region: COG0517 670487001052 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 670487001053 Esterase/lipase [General function prediction only]; Region: COG1647 670487001054 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 670487001055 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 670487001056 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 670487001057 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 670487001058 Flavoprotein; Region: Flavoprotein; pfam02441 670487001059 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 670487001060 substrate binding site; other site 670487001061 dimer interface; other site 670487001062 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 670487001063 FAD binding pocket [chemical binding]; other site 670487001064 FAD binding motif [chemical binding]; other site 670487001065 phosphate binding motif [ion binding]; other site 670487001066 beta-alpha-beta structure motif; other site 670487001067 NAD binding pocket [chemical binding]; other site 670487001068 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 670487001069 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 670487001070 putative NAD(P) binding site [chemical binding]; other site 670487001071 catalytic Zn binding site [ion binding]; other site 670487001072 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 670487001073 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 670487001074 putative active site; other site 670487001075 catalytic residue [active] 670487001076 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 670487001077 metal binding site [ion binding]; metal-binding site 670487001078 substrate binding site [chemical binding]; other site 670487001079 hexamer interface [polypeptide binding]; other site 670487001080 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 670487001081 Phosphotransferase enzyme family; Region: APH; pfam01636 670487001082 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 670487001083 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 670487001084 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487001085 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 670487001086 TM-ABC transporter signature motif; other site 670487001087 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 670487001088 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 670487001089 Walker A/P-loop; other site 670487001090 ATP binding site [chemical binding]; other site 670487001091 Q-loop/lid; other site 670487001092 ABC transporter signature motif; other site 670487001093 Walker B; other site 670487001094 D-loop; other site 670487001095 H-loop/switch region; other site 670487001096 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 670487001097 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 670487001098 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_5; cd06313 670487001099 putative ligand binding site [chemical binding]; other site 670487001100 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 670487001101 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 670487001102 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 670487001103 putative active site [active] 670487001104 Sugar fermentation stimulation protein; Region: SfsA; cl00647 670487001105 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 670487001106 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 670487001107 dimer interface [polypeptide binding]; other site 670487001108 motif 1; other site 670487001109 active site 670487001110 motif 2; other site 670487001111 motif 3; other site 670487001112 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 670487001113 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 670487001114 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 670487001115 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 670487001116 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 670487001117 Cna protein B-type domain; Region: Cna_B_2; pfam13715 670487001118 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 670487001119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487001120 motif II; other site 670487001121 adenylosuccinate lyase; Provisional; Region: PRK07492 670487001122 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 670487001123 tetramer interface [polypeptide binding]; other site 670487001124 active site 670487001125 RmuC family; Region: RmuC; pfam02646 670487001126 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 670487001127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 670487001128 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 670487001129 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 670487001130 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487001131 Zn2+ binding site [ion binding]; other site 670487001132 Mg2+ binding site [ion binding]; other site 670487001133 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 670487001134 synthetase active site [active] 670487001135 NTP binding site [chemical binding]; other site 670487001136 metal binding site [ion binding]; metal-binding site 670487001137 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 670487001138 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 670487001139 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 670487001140 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 670487001141 tetramer interface [polypeptide binding]; other site 670487001142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487001143 catalytic residue [active] 670487001144 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 670487001145 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 670487001146 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 670487001147 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 670487001148 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 670487001149 putative binding site residues; other site 670487001150 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 670487001151 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 670487001152 ABC-ATPase subunit interface; other site 670487001153 dimer interface [polypeptide binding]; other site 670487001154 putative PBP binding regions; other site 670487001155 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 670487001156 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 670487001157 Walker A/P-loop; other site 670487001158 ATP binding site [chemical binding]; other site 670487001159 Q-loop/lid; other site 670487001160 ABC transporter signature motif; other site 670487001161 Walker B; other site 670487001162 D-loop; other site 670487001163 H-loop/switch region; other site 670487001164 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 670487001165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 670487001166 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 670487001167 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 670487001168 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 670487001169 catalytic triad [active] 670487001170 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 670487001171 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 670487001172 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 670487001173 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 670487001174 catalytic residue [active] 670487001175 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 670487001176 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 670487001177 catalytic core [active] 670487001178 cobyric acid synthase; Provisional; Region: PRK00784 670487001179 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 670487001180 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 670487001181 catalytic triad [active] 670487001182 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 670487001183 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 670487001184 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 670487001185 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487001186 Cytochrome c; Region: Cytochrom_C; pfam00034 670487001187 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487001188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001189 dimer interface [polypeptide binding]; other site 670487001190 conserved gate region; other site 670487001191 putative PBP binding loops; other site 670487001192 ABC-ATPase subunit interface; other site 670487001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001194 dimer interface [polypeptide binding]; other site 670487001195 conserved gate region; other site 670487001196 putative PBP binding loops; other site 670487001197 ABC-ATPase subunit interface; other site 670487001198 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 670487001199 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 670487001200 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 670487001201 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 670487001202 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 670487001203 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 670487001204 putative active site [active] 670487001205 Beta-lactamase; Region: Beta-lactamase; pfam00144 670487001206 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 670487001207 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 670487001208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 670487001209 DNA-binding site [nucleotide binding]; DNA binding site 670487001210 UTRA domain; Region: UTRA; pfam07702 670487001211 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 670487001212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 670487001213 putative DNA binding site [nucleotide binding]; other site 670487001214 putative Zn2+ binding site [ion binding]; other site 670487001215 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 670487001216 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 670487001217 putative dimer interface [polypeptide binding]; other site 670487001218 active site pocket [active] 670487001219 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 670487001220 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 670487001221 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 670487001222 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 670487001223 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 670487001224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001225 dimer interface [polypeptide binding]; other site 670487001226 conserved gate region; other site 670487001227 putative PBP binding loops; other site 670487001228 ABC-ATPase subunit interface; other site 670487001229 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487001230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001231 dimer interface [polypeptide binding]; other site 670487001232 conserved gate region; other site 670487001233 putative PBP binding loops; other site 670487001234 ABC-ATPase subunit interface; other site 670487001235 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 670487001236 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 670487001237 active site 670487001238 catalytic site [active] 670487001239 metal binding site [ion binding]; metal-binding site 670487001240 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 670487001241 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 670487001242 catalytic triad [active] 670487001243 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 670487001244 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 670487001245 active site 670487001246 catalytic site [active] 670487001247 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 670487001248 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 670487001249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 670487001250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487001251 active site 670487001252 phosphorylation site [posttranslational modification] 670487001253 intermolecular recognition site; other site 670487001254 dimerization interface [polypeptide binding]; other site 670487001255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 670487001256 DNA binding residues [nucleotide binding] 670487001257 dimerization interface [polypeptide binding]; other site 670487001258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 670487001259 Histidine kinase; Region: HisKA_3; pfam07730 670487001260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487001261 ATP binding site [chemical binding]; other site 670487001262 Mg2+ binding site [ion binding]; other site 670487001263 G-X-G motif; other site 670487001264 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 670487001265 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 670487001266 substrate binding pocket [chemical binding]; other site 670487001267 membrane-bound complex binding site; other site 670487001268 hinge residues; other site 670487001269 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 670487001270 4Fe-4S binding domain; Region: Fer4_6; pfam12837 670487001271 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 670487001272 tetrathionate reductase subunit A; Provisional; Region: PRK14991 670487001273 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 670487001274 putative [Fe4-S4] binding site [ion binding]; other site 670487001275 putative molybdopterin cofactor binding site [chemical binding]; other site 670487001276 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 670487001277 putative molybdopterin cofactor binding site; other site 670487001278 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 670487001279 Clp amino terminal domain; Region: Clp_N; pfam02861 670487001280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487001281 Walker A motif; other site 670487001282 ATP binding site [chemical binding]; other site 670487001283 Walker B motif; other site 670487001284 arginine finger; other site 670487001285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487001286 Walker A motif; other site 670487001287 ATP binding site [chemical binding]; other site 670487001288 Walker B motif; other site 670487001289 arginine finger; other site 670487001290 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 670487001291 Bacterial Ig-like domain; Region: Big_5; pfam13205 670487001292 Bacterial Ig-like domain; Region: Big_5; pfam13205 670487001293 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 670487001294 Predicted GTPase or GTP-binding protein [General function prediction only]; Region: COG1341 670487001295 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 670487001296 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 670487001297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 670487001298 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 670487001299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001300 dimer interface [polypeptide binding]; other site 670487001301 conserved gate region; other site 670487001302 putative PBP binding loops; other site 670487001303 ABC-ATPase subunit interface; other site 670487001304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 670487001305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487001306 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 670487001307 Walker A/P-loop; other site 670487001308 ATP binding site [chemical binding]; other site 670487001309 Q-loop/lid; other site 670487001310 ABC transporter signature motif; other site 670487001311 Walker B; other site 670487001312 D-loop; other site 670487001313 H-loop/switch region; other site 670487001314 Thiamine pyrophosphokinase; Region: TPK; cd07995 670487001315 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 670487001316 active site 670487001317 dimerization interface [polypeptide binding]; other site 670487001318 thiamine binding site [chemical binding]; other site 670487001319 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 670487001320 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 670487001321 Walker A/P-loop; other site 670487001322 ATP binding site [chemical binding]; other site 670487001323 Q-loop/lid; other site 670487001324 ABC transporter signature motif; other site 670487001325 Walker B; other site 670487001326 D-loop; other site 670487001327 H-loop/switch region; other site 670487001328 Uncharacterized conserved protein [Function unknown]; Region: COG0011 670487001329 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 670487001330 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 670487001331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 670487001332 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 670487001333 active site 670487001334 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487001335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487001336 metal binding site [ion binding]; metal-binding site 670487001337 active site 670487001338 I-site; other site 670487001339 Pantoate-beta-alanine ligase; Region: PanC; cd00560 670487001340 pantoate--beta-alanine ligase; Region: panC; TIGR00018 670487001341 active site 670487001342 ATP-binding site [chemical binding]; other site 670487001343 pantoate-binding site; other site 670487001344 HXXH motif; other site 670487001345 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 670487001346 T4 RNase H, C terminal; Region: RNaseH_C; pfam09293 670487001347 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 670487001348 Walker A motif; other site 670487001349 ATP binding site [chemical binding]; other site 670487001350 Walker B motif; other site 670487001351 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 670487001352 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 670487001353 intersubunit interface [polypeptide binding]; other site 670487001354 active site 670487001355 zinc binding site [ion binding]; other site 670487001356 Na+ binding site [ion binding]; other site 670487001357 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 670487001358 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 670487001359 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 670487001360 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 670487001361 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 670487001362 Peptidase family M23; Region: Peptidase_M23; pfam01551 670487001363 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 670487001364 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 670487001365 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 670487001366 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 670487001367 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 670487001368 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 670487001369 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 670487001370 PEGA domain; Region: PEGA; pfam08308 670487001371 PEGA domain; Region: PEGA; pfam08308 670487001372 PEGA domain; Region: PEGA; pfam08308 670487001373 PEGA domain; Region: PEGA; pfam08308 670487001374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 670487001375 active site 670487001376 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 670487001377 Ferredoxin [Energy production and conversion]; Region: COG1146 670487001378 4Fe-4S binding domain; Region: Fer4; cl02805 670487001379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 670487001380 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 670487001381 Predicted integral membrane protein [Function unknown]; Region: COG5652 670487001382 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 670487001383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 670487001384 dimer interface [polypeptide binding]; other site 670487001385 substrate binding site [chemical binding]; other site 670487001386 metal binding site [ion binding]; metal-binding site 670487001387 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 670487001388 DinB superfamily; Region: DinB_2; pfam12867 670487001389 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 670487001390 DNA-binding site [nucleotide binding]; DNA binding site 670487001391 RNA-binding motif; other site 670487001392 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 670487001393 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 670487001394 HIGH motif; other site 670487001395 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 670487001396 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 670487001397 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 670487001398 active site 670487001399 KMSKS motif; other site 670487001400 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 670487001401 tRNA binding surface [nucleotide binding]; other site 670487001402 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 670487001403 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 670487001404 DNA binding residues [nucleotide binding] 670487001405 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 670487001406 metal-binding site [ion binding] 670487001407 mercuric reductase; Region: MerA; TIGR02053 670487001408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 670487001409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 670487001410 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 670487001411 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 670487001412 FAD binding domain; Region: FAD_binding_4; pfam01565 670487001413 Protein of unknown function DUF72; Region: DUF72; pfam01904 670487001414 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 670487001415 active site 670487001416 Ap6A binding site [chemical binding]; other site 670487001417 nudix motif; other site 670487001418 metal binding site [ion binding]; metal-binding site 670487001419 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 670487001420 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 670487001421 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 670487001422 nucleotide binding site [chemical binding]; other site 670487001423 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 670487001424 classical (c) SDRs; Region: SDR_c; cd05233 670487001425 NAD(P) binding site [chemical binding]; other site 670487001426 active site 670487001427 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 670487001428 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 670487001429 active site 670487001430 catalytic tetrad [active] 670487001431 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 670487001432 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 670487001433 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 670487001434 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 670487001435 Subunit I/III interface [polypeptide binding]; other site 670487001436 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 670487001437 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 670487001438 Cytochrome c; Region: Cytochrom_C; cl11414 670487001439 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 670487001440 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 670487001441 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 670487001442 Cytochrome c; Region: Cytochrom_C; pfam00034 670487001443 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 670487001444 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 670487001445 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 670487001446 UbiA prenyltransferase family; Region: UbiA; pfam01040 670487001447 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 670487001448 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 670487001449 active site 670487001450 substrate-binding site [chemical binding]; other site 670487001451 metal-binding site [ion binding] 670487001452 ATP binding site [chemical binding]; other site 670487001453 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 670487001454 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 670487001455 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 670487001456 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 670487001457 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 670487001458 active site 670487001459 Ap6A binding site [chemical binding]; other site 670487001460 nudix motif; other site 670487001461 metal binding site [ion binding]; metal-binding site 670487001462 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 670487001463 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 670487001464 active site 670487001465 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 670487001466 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 670487001467 Walker A; other site 670487001468 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 670487001469 Ligand Binding Site [chemical binding]; other site 670487001470 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 670487001471 Ligand Binding Site [chemical binding]; other site 670487001472 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 670487001473 homotrimer interaction site [polypeptide binding]; other site 670487001474 putative active site [active] 670487001475 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 670487001476 active site 670487001477 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 670487001478 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 670487001479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001480 dimer interface [polypeptide binding]; other site 670487001481 conserved gate region; other site 670487001482 putative PBP binding loops; other site 670487001483 ABC-ATPase subunit interface; other site 670487001484 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487001485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001486 dimer interface [polypeptide binding]; other site 670487001487 conserved gate region; other site 670487001488 putative PBP binding loops; other site 670487001489 ABC-ATPase subunit interface; other site 670487001490 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 670487001491 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 670487001492 substrate binding site [chemical binding]; other site 670487001493 ATP binding site [chemical binding]; other site 670487001494 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 670487001495 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 670487001496 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 670487001497 trimer interface [polypeptide binding]; other site 670487001498 active site 670487001499 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 670487001500 catalytic site [active] 670487001501 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 670487001502 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 670487001503 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 670487001504 active site 670487001505 Zn binding site [ion binding]; other site 670487001506 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 670487001507 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 670487001508 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 670487001509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001510 dimer interface [polypeptide binding]; other site 670487001511 conserved gate region; other site 670487001512 putative PBP binding loops; other site 670487001513 ABC-ATPase subunit interface; other site 670487001514 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 670487001515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001516 ABC-ATPase subunit interface; other site 670487001517 putative PBP binding loops; other site 670487001518 peptidase; Reviewed; Region: PRK13004 670487001519 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 670487001520 metal binding site [ion binding]; metal-binding site 670487001521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 670487001522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 670487001523 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 670487001524 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 670487001525 Walker A/P-loop; other site 670487001526 ATP binding site [chemical binding]; other site 670487001527 Q-loop/lid; other site 670487001528 ABC transporter signature motif; other site 670487001529 Walker B; other site 670487001530 D-loop; other site 670487001531 H-loop/switch region; other site 670487001532 intracellular protease, PfpI family; Region: PfpI; TIGR01382 670487001533 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 670487001534 proposed catalytic triad [active] 670487001535 conserved cys residue [active] 670487001536 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 670487001537 putative active site [active] 670487001538 putative CoA binding site [chemical binding]; other site 670487001539 nudix motif; other site 670487001540 metal binding site [ion binding]; metal-binding site 670487001541 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 670487001542 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 670487001543 homodimer interface [polypeptide binding]; other site 670487001544 metal binding site [ion binding]; metal-binding site 670487001545 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 670487001546 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 670487001547 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 670487001548 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 670487001549 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 670487001550 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 670487001551 Walker A motif; other site 670487001552 ATP binding site [chemical binding]; other site 670487001553 Walker B motif; other site 670487001554 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 670487001555 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 670487001556 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 670487001557 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 670487001558 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487001559 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487001560 metal binding site [ion binding]; metal-binding site 670487001561 active site 670487001562 I-site; other site 670487001563 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 670487001564 CAAX protease self-immunity; Region: Abi; pfam02517 670487001565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487001566 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 670487001567 NAD(P) binding site [chemical binding]; other site 670487001568 active site 670487001569 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 670487001570 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 670487001571 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 670487001572 GTPase CgtA; Reviewed; Region: obgE; PRK12297 670487001573 GTP1/OBG; Region: GTP1_OBG; pfam01018 670487001574 Obg GTPase; Region: Obg; cd01898 670487001575 G1 box; other site 670487001576 GTP/Mg2+ binding site [chemical binding]; other site 670487001577 Switch I region; other site 670487001578 G2 box; other site 670487001579 G3 box; other site 670487001580 Switch II region; other site 670487001581 G4 box; other site 670487001582 G5 box; other site 670487001583 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 670487001584 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 670487001585 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 670487001586 active site 670487001587 (T/H)XGH motif; other site 670487001588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487001589 Zn2+ binding site [ion binding]; other site 670487001590 Mg2+ binding site [ion binding]; other site 670487001591 Transcriptional regulator [Transcription]; Region: LytR; COG1316 670487001592 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 670487001593 hypothetical protein; Reviewed; Region: PRK12497 670487001594 Short C-terminal domain; Region: SHOCT; pfam09851 670487001595 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487001596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487001597 active site 670487001598 phosphorylation site [posttranslational modification] 670487001599 intermolecular recognition site; other site 670487001600 dimerization interface [polypeptide binding]; other site 670487001601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487001602 DNA binding site [nucleotide binding] 670487001603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 670487001604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 670487001605 dimerization interface [polypeptide binding]; other site 670487001606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487001607 dimer interface [polypeptide binding]; other site 670487001608 phosphorylation site [posttranslational modification] 670487001609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487001610 ATP binding site [chemical binding]; other site 670487001611 Mg2+ binding site [ion binding]; other site 670487001612 G-X-G motif; other site 670487001613 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 670487001614 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 670487001615 Multicopper oxidase; Region: Cu-oxidase; pfam00394 670487001616 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 670487001617 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 670487001618 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 670487001619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 670487001620 Soluble P-type ATPase [General function prediction only]; Region: COG4087 670487001621 Domain of unknown function DUF302; Region: DUF302; cl01364 670487001622 Predicted membrane protein [Function unknown]; Region: COG3462 670487001623 Short C-terminal domain; Region: SHOCT; pfam09851 670487001624 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 670487001625 DOMON domain; Region: DOMON; pfam03351 670487001626 putative ligand binding site [chemical binding]; other site 670487001627 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 670487001628 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 670487001629 active site residue [active] 670487001630 YceI-like domain; Region: YceI; pfam04264 670487001631 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487001632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487001633 active site 670487001634 phosphorylation site [posttranslational modification] 670487001635 intermolecular recognition site; other site 670487001636 dimerization interface [polypeptide binding]; other site 670487001637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487001638 DNA binding site [nucleotide binding] 670487001639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 670487001640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487001641 dimer interface [polypeptide binding]; other site 670487001642 phosphorylation site [posttranslational modification] 670487001643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487001644 ATP binding site [chemical binding]; other site 670487001645 Mg2+ binding site [ion binding]; other site 670487001646 G-X-G motif; other site 670487001647 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 670487001648 metal-binding site [ion binding] 670487001649 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 670487001650 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 670487001651 metal-binding site [ion binding] 670487001652 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 670487001653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487001654 motif II; other site 670487001655 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 670487001656 catalytic residues [active] 670487001657 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 670487001658 IHF dimer interface [polypeptide binding]; other site 670487001659 IHF - DNA interface [nucleotide binding]; other site 670487001660 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 670487001661 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 670487001662 putative acyl-acceptor binding pocket; other site 670487001663 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 670487001664 Active_site [active] 670487001665 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 670487001666 dimer interface [polypeptide binding]; other site 670487001667 active site 670487001668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 670487001669 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 670487001670 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 670487001671 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 670487001672 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 670487001673 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 670487001674 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 670487001675 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 670487001676 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 670487001677 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 670487001678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 670487001679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487001680 homodimer interface [polypeptide binding]; other site 670487001681 catalytic residue [active] 670487001682 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 670487001683 putative active site pocket [active] 670487001684 4-fold oligomerization interface [polypeptide binding]; other site 670487001685 metal binding residues [ion binding]; metal-binding site 670487001686 3-fold/trimer interface [polypeptide binding]; other site 670487001687 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 670487001688 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 670487001689 putative active site [active] 670487001690 oxyanion strand; other site 670487001691 catalytic triad [active] 670487001692 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 670487001693 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 670487001694 substrate binding site [chemical binding]; other site 670487001695 ATP binding site [chemical binding]; other site 670487001696 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 670487001697 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487001698 molybdopterin cofactor binding site; other site 670487001699 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487001700 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 670487001701 molybdopterin cofactor binding site; other site 670487001702 MauM/NapG family ferredoxin-type protein; Region: mauM_napG; TIGR00397 670487001703 4Fe-4S binding domain; Region: Fer4_5; pfam12801 670487001704 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 670487001705 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 670487001706 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 670487001707 ferredoxin-type protein; Provisional; Region: PRK10194 670487001708 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 670487001709 structural tetrad; other site 670487001710 NapD protein; Region: NapD; pfam03927 670487001711 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 670487001712 active site clefts [active] 670487001713 zinc binding site [ion binding]; other site 670487001714 dimer interface [polypeptide binding]; other site 670487001715 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 670487001716 MoxR-like ATPases [General function prediction only]; Region: COG0714 670487001717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487001718 ATP binding site [chemical binding]; other site 670487001719 Walker A motif; other site 670487001720 Walker B motif; other site 670487001721 arginine finger; other site 670487001722 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 670487001723 Protein of unknown function DUF58; Region: DUF58; pfam01882 670487001724 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 670487001725 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 670487001726 Moco binding site; other site 670487001727 metal coordination site [ion binding]; other site 670487001728 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 670487001729 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 670487001730 nudix motif; other site 670487001731 Uncharacterized conserved protein [Function unknown]; Region: COG3342 670487001732 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 670487001733 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 670487001734 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 670487001735 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 670487001736 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 670487001737 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 670487001738 dimer interface [polypeptide binding]; other site 670487001739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487001740 catalytic residue [active] 670487001741 FUN14 family; Region: FUN14; pfam04930 670487001742 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 670487001743 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 670487001744 active site 670487001745 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 670487001746 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 670487001747 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 670487001748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001749 dimer interface [polypeptide binding]; other site 670487001750 putative PBP binding loops; other site 670487001751 ABC-ATPase subunit interface; other site 670487001752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487001753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487001754 dimer interface [polypeptide binding]; other site 670487001755 conserved gate region; other site 670487001756 putative PBP binding loops; other site 670487001757 ABC-ATPase subunit interface; other site 670487001758 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 670487001759 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 670487001760 active site 670487001761 homodimer interface [polypeptide binding]; other site 670487001762 catalytic site [active] 670487001763 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 670487001764 glycogen binding site [chemical binding]; other site 670487001765 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 670487001766 active site 670487001767 homodimer interface [polypeptide binding]; other site 670487001768 catalytic site [active] 670487001769 Predicted membrane protein [Function unknown]; Region: COG2855 670487001770 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 670487001771 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 670487001772 FMN binding site [chemical binding]; other site 670487001773 active site 670487001774 catalytic residues [active] 670487001775 substrate binding site [chemical binding]; other site 670487001776 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 670487001777 Protein of unknown function DUF72; Region: DUF72; cl00777 670487001778 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 670487001779 Serine hydrolase (FSH1); Region: FSH1; pfam03959 670487001780 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 670487001781 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 670487001782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487001783 active site 670487001784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 670487001785 PAS fold; Region: PAS_3; pfam08447 670487001786 putative active site [active] 670487001787 heme pocket [chemical binding]; other site 670487001788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 670487001789 PAS domain; Region: PAS_9; pfam13426 670487001790 putative active site [active] 670487001791 heme pocket [chemical binding]; other site 670487001792 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 670487001793 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 670487001794 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487001795 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487001796 metal binding site [ion binding]; metal-binding site 670487001797 active site 670487001798 I-site; other site 670487001799 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 670487001800 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 670487001801 Found in ATP-dependent protease La (LON); Region: LON; smart00464 670487001802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487001803 Walker A motif; other site 670487001804 ATP binding site [chemical binding]; other site 670487001805 Walker B motif; other site 670487001806 arginine finger; other site 670487001807 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 670487001808 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 670487001809 elongation factor Tu; Reviewed; Region: PRK00049 670487001810 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 670487001811 G1 box; other site 670487001812 GEF interaction site [polypeptide binding]; other site 670487001813 GTP/Mg2+ binding site [chemical binding]; other site 670487001814 Switch I region; other site 670487001815 G2 box; other site 670487001816 G3 box; other site 670487001817 Switch II region; other site 670487001818 G4 box; other site 670487001819 G5 box; other site 670487001820 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 670487001821 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 670487001822 Antibiotic Binding Site [chemical binding]; other site 670487001823 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 670487001824 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 670487001825 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 670487001826 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 670487001827 putative homodimer interface [polypeptide binding]; other site 670487001828 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 670487001829 heterodimer interface [polypeptide binding]; other site 670487001830 homodimer interface [polypeptide binding]; other site 670487001831 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 670487001832 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 670487001833 23S rRNA interface [nucleotide binding]; other site 670487001834 L7/L12 interface [polypeptide binding]; other site 670487001835 putative thiostrepton binding site; other site 670487001836 L25 interface [polypeptide binding]; other site 670487001837 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 670487001838 mRNA/rRNA interface [nucleotide binding]; other site 670487001839 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 670487001840 23S rRNA interface [nucleotide binding]; other site 670487001841 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 670487001842 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 670487001843 core dimer interface [polypeptide binding]; other site 670487001844 peripheral dimer interface [polypeptide binding]; other site 670487001845 L10 interface [polypeptide binding]; other site 670487001846 L11 interface [polypeptide binding]; other site 670487001847 putative EF-Tu interaction site [polypeptide binding]; other site 670487001848 putative EF-G interaction site [polypeptide binding]; other site 670487001849 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 670487001850 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 670487001851 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 670487001852 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 670487001853 RPB1 interaction site [polypeptide binding]; other site 670487001854 RPB10 interaction site [polypeptide binding]; other site 670487001855 RPB11 interaction site [polypeptide binding]; other site 670487001856 RPB3 interaction site [polypeptide binding]; other site 670487001857 RPB12 interaction site [polypeptide binding]; other site 670487001858 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 670487001859 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 670487001860 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 670487001861 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 670487001862 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 670487001863 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 670487001864 cleft; other site 670487001865 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 670487001866 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 670487001867 DNA binding site [nucleotide binding] 670487001868 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 670487001869 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 670487001870 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 670487001871 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 670487001872 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 670487001873 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 670487001874 Walker A/P-loop; other site 670487001875 ATP binding site [chemical binding]; other site 670487001876 Q-loop/lid; other site 670487001877 ABC transporter signature motif; other site 670487001878 Walker B; other site 670487001879 D-loop; other site 670487001880 H-loop/switch region; other site 670487001881 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 670487001882 TPR repeat; Region: TPR_11; pfam13414 670487001883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487001884 binding surface 670487001885 TPR motif; other site 670487001886 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 670487001887 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 670487001888 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 670487001889 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 670487001890 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 670487001891 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 670487001892 catalytic residues [active] 670487001893 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 670487001894 TPR repeat; Region: TPR_11; pfam13414 670487001895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487001896 binding surface 670487001897 TPR motif; other site 670487001898 TPR repeat; Region: TPR_11; pfam13414 670487001899 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 670487001900 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487001901 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 670487001902 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 670487001903 iron-sulfur cluster [ion binding]; other site 670487001904 [2Fe-2S] cluster binding site [ion binding]; other site 670487001905 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 670487001906 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 670487001907 active site 670487001908 HIGH motif; other site 670487001909 dimer interface [polypeptide binding]; other site 670487001910 KMSKS motif; other site 670487001911 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 670487001912 RNA binding surface [nucleotide binding]; other site 670487001913 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 670487001914 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 670487001915 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 670487001916 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 670487001917 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 670487001918 rod shape-determining protein MreC; Provisional; Region: PRK13922 670487001919 rod shape-determining protein MreC; Region: MreC; pfam04085 670487001920 Maf-like protein; Region: Maf; pfam02545 670487001921 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 670487001922 active site 670487001923 dimer interface [polypeptide binding]; other site 670487001924 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 670487001925 PLD-like domain; Region: PLDc_2; pfam13091 670487001926 putative active site [active] 670487001927 catalytic site [active] 670487001928 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 670487001929 PLD-like domain; Region: PLDc_2; pfam13091 670487001930 putative active site [active] 670487001931 catalytic site [active] 670487001932 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 670487001933 intersubunit interface [polypeptide binding]; other site 670487001934 active site 670487001935 catalytic residue [active] 670487001936 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 670487001937 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 670487001938 active site 670487001939 metal binding site [ion binding]; metal-binding site 670487001940 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 670487001941 NADH dehydrogenase subunit B; Validated; Region: PRK06411 670487001942 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 670487001943 NADH dehydrogenase subunit D; Validated; Region: PRK06075 670487001944 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 670487001945 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 670487001946 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 670487001947 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 670487001948 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 670487001949 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 670487001950 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 670487001951 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 670487001952 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 670487001953 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 670487001954 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 670487001955 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 670487001956 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 670487001957 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 670487001958 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 670487001959 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 670487001960 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 670487001961 Ligand Binding Site [chemical binding]; other site 670487001962 TIGR00269 family protein; Region: TIGR00269 670487001963 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 670487001964 thiS-thiF/thiG interaction site; other site 670487001965 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 670487001966 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 670487001967 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 670487001968 active site 670487001969 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 670487001970 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 670487001971 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 670487001972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487001973 Walker A motif; other site 670487001974 ATP binding site [chemical binding]; other site 670487001975 Walker B motif; other site 670487001976 arginine finger; other site 670487001977 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 670487001978 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 670487001979 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 670487001980 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 670487001981 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 670487001982 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487001983 Zn2+ binding site [ion binding]; other site 670487001984 Mg2+ binding site [ion binding]; other site 670487001985 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 670487001986 oligomerization interface [polypeptide binding]; other site 670487001987 active site 670487001988 metal binding site [ion binding]; metal-binding site 670487001989 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 670487001990 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 670487001991 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 670487001992 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 670487001993 NlpC/P60 family; Region: NLPC_P60; cl17555 670487001994 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 670487001995 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 670487001996 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 670487001997 RNA binding surface [nucleotide binding]; other site 670487001998 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 670487001999 active site 670487002000 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 670487002001 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 670487002002 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 670487002003 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 670487002004 RNA binding surface [nucleotide binding]; other site 670487002005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487002006 S-adenosylmethionine binding site [chemical binding]; other site 670487002007 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 670487002008 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 670487002009 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 670487002010 dimerization interface [polypeptide binding]; other site 670487002011 ATP binding site [chemical binding]; other site 670487002012 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 670487002013 ATP binding site [chemical binding]; other site 670487002014 dimerization interface [polypeptide binding]; other site 670487002015 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 670487002016 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 670487002017 conserved cys residue [active] 670487002018 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 670487002019 active site 670487002020 ATP binding site [chemical binding]; other site 670487002021 substrate binding site [chemical binding]; other site 670487002022 AIR carboxylase; Region: AIRC; pfam00731 670487002023 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 670487002024 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 670487002025 active site 670487002026 tetramer interface [polypeptide binding]; other site 670487002027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487002028 active site 670487002029 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 670487002030 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 670487002031 ATP-grasp domain; Region: ATP-grasp_4; cl17255 670487002032 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 670487002033 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 670487002034 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 670487002035 dimerization interface [polypeptide binding]; other site 670487002036 putative ATP binding site [chemical binding]; other site 670487002037 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 670487002038 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 670487002039 active site 670487002040 substrate binding site [chemical binding]; other site 670487002041 cosubstrate binding site; other site 670487002042 catalytic site [active] 670487002043 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 670487002044 NADH dehydrogenase subunit B; Validated; Region: PRK06411 670487002045 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 670487002046 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 670487002047 NADH dehydrogenase subunit D; Validated; Region: PRK06075 670487002048 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 670487002049 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 670487002050 putative dimer interface [polypeptide binding]; other site 670487002051 [2Fe-2S] cluster binding site [ion binding]; other site 670487002052 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 670487002053 SLBB domain; Region: SLBB; pfam10531 670487002054 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 670487002055 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 670487002056 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 670487002057 catalytic loop [active] 670487002058 iron binding site [ion binding]; other site 670487002059 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 670487002060 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487002061 molybdopterin cofactor binding site; other site 670487002062 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487002063 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 670487002064 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 670487002065 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 670487002066 4Fe-4S binding domain; Region: Fer4; pfam00037 670487002067 4Fe-4S binding domain; Region: Fer4; pfam00037 670487002068 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 670487002069 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 670487002070 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 670487002071 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 670487002072 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 670487002073 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 670487002074 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 670487002075 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 670487002076 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 670487002077 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 670487002078 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 670487002079 active site 670487002080 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 670487002081 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 670487002082 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 670487002083 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 670487002084 DctM-like transporters; Region: DctM; pfam06808 670487002085 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 670487002086 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 670487002087 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 670487002088 active site 670487002089 H+ Antiporter protein; Region: 2A0121; TIGR00900 670487002090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487002091 putative substrate translocation pore; other site 670487002092 Putative cyclase; Region: Cyclase; pfam04199 670487002093 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 670487002094 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 670487002095 active site 670487002096 homodimer interface [polypeptide binding]; other site 670487002097 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 670487002098 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 670487002099 Mg++ binding site [ion binding]; other site 670487002100 putative catalytic motif [active] 670487002101 substrate binding site [chemical binding]; other site 670487002102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487002103 active site 670487002104 Phosphotransferase enzyme family; Region: APH; pfam01636 670487002105 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 670487002106 active site 670487002107 substrate binding site [chemical binding]; other site 670487002108 ATP binding site [chemical binding]; other site 670487002109 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 670487002110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487002111 FeS/SAM binding site; other site 670487002112 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 670487002113 dsRNA binding site [nucleotide binding]; other site 670487002114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 670487002115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487002116 active site 670487002117 phosphorylation site [posttranslational modification] 670487002118 intermolecular recognition site; other site 670487002119 dimerization interface [polypeptide binding]; other site 670487002120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 670487002121 DNA binding residues [nucleotide binding] 670487002122 dimerization interface [polypeptide binding]; other site 670487002123 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 670487002124 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 670487002125 metal binding site [ion binding]; metal-binding site 670487002126 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 670487002127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 670487002128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487002129 Walker A/P-loop; other site 670487002130 ATP binding site [chemical binding]; other site 670487002131 Q-loop/lid; other site 670487002132 ABC transporter signature motif; other site 670487002133 Walker B; other site 670487002134 D-loop; other site 670487002135 H-loop/switch region; other site 670487002136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 670487002137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 670487002138 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 670487002139 Walker A/P-loop; other site 670487002140 ATP binding site [chemical binding]; other site 670487002141 Q-loop/lid; other site 670487002142 ABC transporter signature motif; other site 670487002143 Walker B; other site 670487002144 D-loop; other site 670487002145 H-loop/switch region; other site 670487002146 Protein of unknown function (DUF454); Region: DUF454; pfam04304 670487002147 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 670487002148 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 670487002149 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 670487002150 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 670487002151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 670487002152 ABC transporter; Region: ABC_tran_2; pfam12848 670487002153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 670487002154 membrane protein; Provisional; Region: PRK14401 670487002155 Transcriptional regulators [Transcription]; Region: PurR; COG1609 670487002156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 670487002157 DNA binding site [nucleotide binding] 670487002158 domain linker motif; other site 670487002159 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 670487002160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 670487002161 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 670487002162 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 670487002163 Preprotein translocase SecG subunit; Region: SecG; pfam03840 670487002164 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 670487002165 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 670487002166 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 670487002167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487002168 putative PBP binding loops; other site 670487002169 dimer interface [polypeptide binding]; other site 670487002170 ABC-ATPase subunit interface; other site 670487002171 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 670487002172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487002173 dimer interface [polypeptide binding]; other site 670487002174 conserved gate region; other site 670487002175 putative PBP binding loops; other site 670487002176 ABC-ATPase subunit interface; other site 670487002177 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 670487002178 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 670487002179 Walker A/P-loop; other site 670487002180 ATP binding site [chemical binding]; other site 670487002181 Q-loop/lid; other site 670487002182 ABC transporter signature motif; other site 670487002183 Walker B; other site 670487002184 D-loop; other site 670487002185 H-loop/switch region; other site 670487002186 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 670487002187 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 670487002188 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 670487002189 Walker A/P-loop; other site 670487002190 ATP binding site [chemical binding]; other site 670487002191 Q-loop/lid; other site 670487002192 ABC transporter signature motif; other site 670487002193 Walker B; other site 670487002194 D-loop; other site 670487002195 H-loop/switch region; other site 670487002196 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 670487002197 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 670487002198 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 670487002199 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 670487002200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487002201 Radical SAM superfamily; Region: Radical_SAM; pfam04055 670487002202 FeS/SAM binding site; other site 670487002203 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 670487002204 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 670487002205 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 670487002206 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 670487002207 MarR family; Region: MarR_2; cl17246 670487002208 H+ Antiporter protein; Region: 2A0121; TIGR00900 670487002209 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 670487002210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 670487002211 active site 670487002212 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 670487002213 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 670487002214 histidinol dehydrogenase; Region: hisD; TIGR00069 670487002215 NAD binding site [chemical binding]; other site 670487002216 dimerization interface [polypeptide binding]; other site 670487002217 product binding site; other site 670487002218 substrate binding site [chemical binding]; other site 670487002219 zinc binding site [ion binding]; other site 670487002220 catalytic residues [active] 670487002221 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 670487002222 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 670487002223 B12 binding site [chemical binding]; other site 670487002224 cobalt ligand [ion binding]; other site 670487002225 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 670487002226 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 670487002227 GIY-YIG motif/motif A; other site 670487002228 active site 670487002229 catalytic site [active] 670487002230 putative DNA binding site [nucleotide binding]; other site 670487002231 metal binding site [ion binding]; metal-binding site 670487002232 UvrB/uvrC motif; Region: UVR; pfam02151 670487002233 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 670487002234 NADH-quinone oxidoreductase chain 15; Region: NADH_Oxid_Nqo15; pfam11497 670487002235 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 670487002236 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 670487002237 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 670487002238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487002239 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 670487002240 P loop; other site 670487002241 Walker A/P-loop; other site 670487002242 ATP binding site [chemical binding]; other site 670487002243 GTP binding site [chemical binding]; other site 670487002244 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 670487002245 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 670487002246 HIGH motif; other site 670487002247 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 670487002248 active site 670487002249 KMSKS motif; other site 670487002250 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 670487002251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 670487002252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487002253 dimer interface [polypeptide binding]; other site 670487002254 conserved gate region; other site 670487002255 putative PBP binding loops; other site 670487002256 ABC-ATPase subunit interface; other site 670487002257 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487002258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487002259 dimer interface [polypeptide binding]; other site 670487002260 conserved gate region; other site 670487002261 putative PBP binding loops; other site 670487002262 ABC-ATPase subunit interface; other site 670487002263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 670487002264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 670487002265 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 670487002266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 670487002267 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 670487002268 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 670487002269 phosphoenolpyruvate synthase; Validated; Region: PRK06464 670487002270 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 670487002271 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 670487002272 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 670487002273 Bacitracin resistance protein BacA; Region: BacA; pfam02673 670487002274 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 670487002275 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 670487002276 23S rRNA interface [nucleotide binding]; other site 670487002277 L3 interface [polypeptide binding]; other site 670487002278 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 670487002279 aromatic arch; other site 670487002280 DCoH dimer interaction site [polypeptide binding]; other site 670487002281 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 670487002282 DCoH tetramer interaction site [polypeptide binding]; other site 670487002283 substrate binding site [chemical binding]; other site 670487002284 argininosuccinate synthase; Provisional; Region: PRK13820 670487002285 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 670487002286 ANP binding site [chemical binding]; other site 670487002287 Substrate Binding Site II [chemical binding]; other site 670487002288 Substrate Binding Site I [chemical binding]; other site 670487002289 argininosuccinate lyase; Provisional; Region: PRK00855 670487002290 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 670487002291 active sites [active] 670487002292 tetramer interface [polypeptide binding]; other site 670487002293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 670487002294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 670487002295 Coenzyme A binding pocket [chemical binding]; other site 670487002296 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 670487002297 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 670487002298 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 670487002299 catalytic site [active] 670487002300 subunit interface [polypeptide binding]; other site 670487002301 Cupin domain; Region: Cupin_2; pfam07883 670487002302 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 670487002303 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 670487002304 Potassium binding sites [ion binding]; other site 670487002305 Cesium cation binding sites [ion binding]; other site 670487002306 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 670487002307 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 670487002308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487002309 FeS/SAM binding site; other site 670487002310 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 670487002311 nucleotide binding site/active site [active] 670487002312 HIT family signature motif; other site 670487002313 catalytic residue [active] 670487002314 Bifunctional nuclease; Region: DNase-RNase; pfam02577 670487002315 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487002316 active site 670487002317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487002318 active site 670487002319 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 670487002320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 670487002321 Walker A/P-loop; other site 670487002322 ATP binding site [chemical binding]; other site 670487002323 Q-loop/lid; other site 670487002324 ABC transporter signature motif; other site 670487002325 Walker B; other site 670487002326 D-loop; other site 670487002327 H-loop/switch region; other site 670487002328 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 670487002329 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 670487002330 ligand binding site [chemical binding]; other site 670487002331 flexible hinge region; other site 670487002332 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 670487002333 putative switch regulator; other site 670487002334 non-specific DNA interactions [nucleotide binding]; other site 670487002335 DNA binding site [nucleotide binding] 670487002336 sequence specific DNA binding site [nucleotide binding]; other site 670487002337 putative cAMP binding site [chemical binding]; other site 670487002338 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 670487002339 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 670487002340 substrate binding site [chemical binding]; other site 670487002341 hexamer interface [polypeptide binding]; other site 670487002342 metal binding site [ion binding]; metal-binding site 670487002343 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 670487002344 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 670487002345 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 670487002346 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 670487002347 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 670487002348 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 670487002349 substrate binding site [chemical binding]; other site 670487002350 oxyanion hole (OAH) forming residues; other site 670487002351 trimer interface [polypeptide binding]; other site 670487002352 HD supefamily hydrolase [General function prediction only]; Region: COG3294 670487002353 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 670487002354 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 670487002355 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 670487002356 ligand binding site [chemical binding]; other site 670487002357 flexible hinge region; other site 670487002358 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 670487002359 putative switch regulator; other site 670487002360 non-specific DNA interactions [nucleotide binding]; other site 670487002361 DNA binding site [nucleotide binding] 670487002362 sequence specific DNA binding site [nucleotide binding]; other site 670487002363 putative cAMP binding site [chemical binding]; other site 670487002364 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487002365 active site 670487002366 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 670487002367 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 670487002368 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 670487002369 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 670487002370 Walker A/P-loop; other site 670487002371 ATP binding site [chemical binding]; other site 670487002372 Q-loop/lid; other site 670487002373 ABC transporter signature motif; other site 670487002374 Walker B; other site 670487002375 D-loop; other site 670487002376 H-loop/switch region; other site 670487002377 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 670487002378 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 670487002379 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 670487002380 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 670487002381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487002382 NAD(P) binding site [chemical binding]; other site 670487002383 active site 670487002384 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 670487002385 tartrate dehydrogenase; Region: TTC; TIGR02089 670487002386 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 670487002387 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 670487002388 substrate binding site [chemical binding]; other site 670487002389 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 670487002390 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 670487002391 substrate binding site [chemical binding]; other site 670487002392 ligand binding site [chemical binding]; other site 670487002393 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 670487002394 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 670487002395 PYR/PP interface [polypeptide binding]; other site 670487002396 dimer interface [polypeptide binding]; other site 670487002397 TPP binding site [chemical binding]; other site 670487002398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 670487002399 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 670487002400 TPP-binding site [chemical binding]; other site 670487002401 dimer interface [polypeptide binding]; other site 670487002402 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 670487002403 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 670487002404 putative valine binding site [chemical binding]; other site 670487002405 dimer interface [polypeptide binding]; other site 670487002406 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 670487002407 ketol-acid reductoisomerase; Provisional; Region: PRK05479 670487002408 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 670487002409 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 670487002410 2-isopropylmalate synthase; Validated; Region: PRK00915 670487002411 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 670487002412 active site 670487002413 catalytic residues [active] 670487002414 metal binding site [ion binding]; metal-binding site 670487002415 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 670487002416 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 670487002417 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 670487002418 active site 670487002419 catalytic residues [active] 670487002420 metal binding site [ion binding]; metal-binding site 670487002421 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 670487002422 Bacterial transcriptional activator domain; Region: BTAD; smart01043 670487002423 AAA ATPase domain; Region: AAA_16; pfam13191 670487002424 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 670487002425 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 670487002426 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 670487002427 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 670487002428 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 670487002429 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 670487002430 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 670487002431 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 670487002432 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 670487002433 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 670487002434 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 670487002435 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 670487002436 active site 670487002437 catalytic site [active] 670487002438 substrate binding site [chemical binding]; other site 670487002439 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 670487002440 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 670487002441 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 670487002442 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 670487002443 ATP-binding site [chemical binding]; other site 670487002444 Sugar specificity; other site 670487002445 Pyrimidine base specificity; other site 670487002446 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 670487002447 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 670487002448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 670487002449 catalytic residue [active] 670487002450 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 670487002451 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 670487002452 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 670487002453 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487002454 Cu(I) binding site [ion binding]; other site 670487002455 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 670487002456 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 670487002457 nucleotide binding pocket [chemical binding]; other site 670487002458 K-X-D-G motif; other site 670487002459 catalytic site [active] 670487002460 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 670487002461 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 670487002462 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 670487002463 Dimer interface [polypeptide binding]; other site 670487002464 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 670487002465 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 670487002466 ligand binding site [chemical binding]; other site 670487002467 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 670487002468 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 670487002469 Walker A/P-loop; other site 670487002470 ATP binding site [chemical binding]; other site 670487002471 Q-loop/lid; other site 670487002472 ABC transporter signature motif; other site 670487002473 Walker B; other site 670487002474 D-loop; other site 670487002475 H-loop/switch region; other site 670487002476 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 670487002477 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 670487002478 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 670487002479 putative active site [active] 670487002480 metal binding site [ion binding]; metal-binding site 670487002481 homodimer binding site [polypeptide binding]; other site 670487002482 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 670487002483 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 670487002484 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 670487002485 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 670487002486 active site 670487002487 metal binding site [ion binding]; metal-binding site 670487002488 Uncharacterized conserved protein [Function unknown]; Region: COG1432 670487002489 LabA_like proteins; Region: LabA; cd10911 670487002490 putative metal binding site [ion binding]; other site 670487002491 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 670487002492 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 670487002493 DNA primase, catalytic core; Region: dnaG; TIGR01391 670487002494 CHC2 zinc finger; Region: zf-CHC2; pfam01807 670487002495 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 670487002496 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 670487002497 active site 670487002498 metal binding site [ion binding]; metal-binding site 670487002499 interdomain interaction site; other site 670487002500 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 670487002501 Double zinc ribbon; Region: DZR; pfam12773 670487002502 cyclase homology domain; Region: CHD; cd07302 670487002503 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 670487002504 nucleotidyl binding site; other site 670487002505 metal binding site [ion binding]; metal-binding site 670487002506 dimer interface [polypeptide binding]; other site 670487002507 AAA ATPase domain; Region: AAA_16; pfam13191 670487002508 Archaeal ATPase; Region: Arch_ATPase; pfam01637 670487002509 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 670487002510 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 670487002511 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 670487002512 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 670487002513 Surface antigen; Region: Bac_surface_Ag; pfam01103 670487002514 purine nucleoside phosphorylase; Provisional; Region: PRK08202 670487002515 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 670487002516 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 670487002517 catalytic residue [active] 670487002518 DivIVA protein; Region: DivIVA; pfam05103 670487002519 DivIVA domain; Region: DivI1A_domain; TIGR03544 670487002520 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 670487002521 putative active site [active] 670487002522 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 670487002523 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 670487002524 HflX GTPase family; Region: HflX; cd01878 670487002525 G1 box; other site 670487002526 GTP/Mg2+ binding site [chemical binding]; other site 670487002527 Switch I region; other site 670487002528 G2 box; other site 670487002529 G3 box; other site 670487002530 Switch II region; other site 670487002531 G4 box; other site 670487002532 G5 box; other site 670487002533 SurA N-terminal domain; Region: SurA_N; pfam09312 670487002534 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 670487002535 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 670487002536 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 670487002537 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 670487002538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 670487002539 active site 670487002540 metal binding site [ion binding]; metal-binding site 670487002541 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 670487002542 putative active site [active] 670487002543 catalytic triad [active] 670487002544 putative dimer interface [polypeptide binding]; other site 670487002545 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 670487002546 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 670487002547 purine monophosphate binding site [chemical binding]; other site 670487002548 dimer interface [polypeptide binding]; other site 670487002549 putative catalytic residues [active] 670487002550 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 670487002551 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 670487002552 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 670487002553 Fe-S cluster binding site [ion binding]; other site 670487002554 active site 670487002555 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 670487002556 GMP synthase; Reviewed; Region: guaA; PRK00074 670487002557 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 670487002558 AMP/PPi binding site [chemical binding]; other site 670487002559 candidate oxyanion hole; other site 670487002560 catalytic triad [active] 670487002561 potential glutamine specificity residues [chemical binding]; other site 670487002562 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 670487002563 ATP Binding subdomain [chemical binding]; other site 670487002564 Ligand Binding sites [chemical binding]; other site 670487002565 Dimerization subdomain; other site 670487002566 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 670487002567 RNA/DNA hybrid binding site [nucleotide binding]; other site 670487002568 active site 670487002569 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 670487002570 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487002571 putative catalytic residue [active] 670487002572 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 670487002573 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 670487002574 substrate binding site [chemical binding]; other site 670487002575 Predicted transcriptional regulator [Transcription]; Region: COG2345 670487002576 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 670487002577 Uncharacterized conserved protein [Function unknown]; Region: COG3743 670487002578 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 670487002579 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 670487002580 dimerization interface [polypeptide binding]; other site 670487002581 ligand binding site [chemical binding]; other site 670487002582 NADP binding site [chemical binding]; other site 670487002583 catalytic site [active] 670487002584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 670487002585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 670487002586 Coenzyme A binding pocket [chemical binding]; other site 670487002587 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 670487002588 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 670487002589 ssDNA binding site; other site 670487002590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 670487002591 ATP binding site [chemical binding]; other site 670487002592 putative Mg++ binding site [ion binding]; other site 670487002593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 670487002594 nucleotide binding region [chemical binding]; other site 670487002595 ATP-binding site [chemical binding]; other site 670487002596 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 670487002597 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 670487002598 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 670487002599 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 670487002600 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 670487002601 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 670487002602 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 670487002603 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 670487002604 EamA-like transporter family; Region: EamA; pfam00892 670487002605 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 670487002606 EamA-like transporter family; Region: EamA; pfam00892 670487002607 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 670487002608 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 670487002609 active site 670487002610 catalytic residues [active] 670487002611 metal binding site [ion binding]; metal-binding site 670487002612 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 670487002613 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 670487002614 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 670487002615 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 670487002616 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 670487002617 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 670487002618 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 670487002619 active site 670487002620 nucleophile elbow; other site 670487002621 Recombination protein O N terminal; Region: RecO_N; pfam11967 670487002622 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 670487002623 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 670487002624 active sites [active] 670487002625 tetramer interface [polypeptide binding]; other site 670487002626 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 670487002627 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 670487002628 B12 binding site [chemical binding]; other site 670487002629 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487002630 FeS/SAM binding site; other site 670487002631 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 670487002632 PrcB C-terminal; Region: PrcB_C; pfam14343 670487002633 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 670487002634 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 670487002635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487002636 dimer interface [polypeptide binding]; other site 670487002637 conserved gate region; other site 670487002638 putative PBP binding loops; other site 670487002639 ABC-ATPase subunit interface; other site 670487002640 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 670487002641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487002642 dimer interface [polypeptide binding]; other site 670487002643 conserved gate region; other site 670487002644 putative PBP binding loops; other site 670487002645 ABC-ATPase subunit interface; other site 670487002646 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 670487002647 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 670487002648 peptide binding site [polypeptide binding]; other site 670487002649 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 670487002650 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 670487002651 Walker A/P-loop; other site 670487002652 ATP binding site [chemical binding]; other site 670487002653 Q-loop/lid; other site 670487002654 ABC transporter signature motif; other site 670487002655 Walker B; other site 670487002656 D-loop; other site 670487002657 H-loop/switch region; other site 670487002658 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 670487002659 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 670487002660 Walker A/P-loop; other site 670487002661 ATP binding site [chemical binding]; other site 670487002662 Q-loop/lid; other site 670487002663 ABC transporter signature motif; other site 670487002664 Walker B; other site 670487002665 D-loop; other site 670487002666 H-loop/switch region; other site 670487002667 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 670487002668 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 670487002669 TM-ABC transporter signature motif; other site 670487002670 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487002671 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 670487002672 TM-ABC transporter signature motif; other site 670487002673 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 670487002674 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 670487002675 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 670487002676 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 670487002677 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 670487002678 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 670487002679 Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406 670487002680 putative active site [active] 670487002681 putative metal binding site [ion binding]; other site 670487002682 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 670487002683 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 670487002684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 670487002685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 670487002686 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 670487002687 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 670487002688 ligand binding site [chemical binding]; other site 670487002689 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 670487002690 putative switch regulator; other site 670487002691 non-specific DNA interactions [nucleotide binding]; other site 670487002692 DNA binding site [nucleotide binding] 670487002693 sequence specific DNA binding site [nucleotide binding]; other site 670487002694 putative cAMP binding site [chemical binding]; other site 670487002695 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 670487002696 DNA gyrase subunit A; Validated; Region: PRK05560 670487002697 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 670487002698 CAP-like domain; other site 670487002699 active site 670487002700 primary dimer interface [polypeptide binding]; other site 670487002701 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 670487002702 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 670487002703 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 670487002704 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 670487002705 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 670487002706 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 670487002707 Uncharacterized conserved protein [Function unknown]; Region: COG2947 670487002708 FAD binding domain; Region: FAD_binding_4; pfam01565 670487002709 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 670487002710 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 670487002711 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 670487002712 active site 670487002713 dimerization interface [polypeptide binding]; other site 670487002714 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 670487002715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 670487002716 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 670487002717 G-X-X-G motif; other site 670487002718 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 670487002719 RxxxH motif; other site 670487002720 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 670487002721 Haemolytic domain; Region: Haemolytic; pfam01809 670487002722 Ribonuclease P; Region: Ribonuclease_P; cl00457 670487002723 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 670487002724 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 670487002725 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 670487002726 active site 670487002727 HIGH motif; other site 670487002728 dimer interface [polypeptide binding]; other site 670487002729 KMSKS motif; other site 670487002730 ScpA/B protein; Region: ScpA_ScpB; cl00598 670487002731 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 670487002732 active site 670487002733 metal binding site [ion binding]; metal-binding site 670487002734 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 670487002735 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 670487002736 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 670487002737 GAF domain; Region: GAF; pfam01590 670487002738 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 670487002739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487002740 Zn2+ binding site [ion binding]; other site 670487002741 Mg2+ binding site [ion binding]; other site 670487002742 putative acyltransferase; Provisional; Region: PRK05790 670487002743 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 670487002744 dimer interface [polypeptide binding]; other site 670487002745 active site 670487002746 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 670487002747 Protein of unknown function (DUF503); Region: DUF503; pfam04456 670487002748 guanine deaminase; Provisional; Region: PRK09228 670487002749 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 670487002750 active site 670487002751 aconitate hydratase; Validated; Region: PRK09277 670487002752 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 670487002753 substrate binding site [chemical binding]; other site 670487002754 ligand binding site [chemical binding]; other site 670487002755 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 670487002756 substrate binding site [chemical binding]; other site 670487002757 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 670487002758 Protein of unknown function (DUF1999); Region: DUF1999; pfam09390 670487002759 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 670487002760 Glycoprotease family; Region: Peptidase_M22; pfam00814 670487002761 ATP-dependent DNA ligase; Provisional; Region: PRK01109 670487002762 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 670487002763 active site 670487002764 DNA binding site [nucleotide binding] 670487002765 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_I; cd07969 670487002766 DNA binding site [nucleotide binding] 670487002767 Protein of unknown function DUF58; Region: DUF58; pfam01882 670487002768 MoxR-like ATPases [General function prediction only]; Region: COG0714 670487002769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487002770 Walker A motif; other site 670487002771 ATP binding site [chemical binding]; other site 670487002772 Walker B motif; other site 670487002773 arginine finger; other site 670487002774 thymidine kinase; Provisional; Region: PRK04296 670487002775 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 670487002776 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 670487002777 putative dimer interface [polypeptide binding]; other site 670487002778 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 670487002779 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 670487002780 acetyl-CoA synthetase; Provisional; Region: PRK00174 670487002781 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 670487002782 active site 670487002783 CoA binding site [chemical binding]; other site 670487002784 acyl-activating enzyme (AAE) consensus motif; other site 670487002785 AMP binding site [chemical binding]; other site 670487002786 acetate binding site [chemical binding]; other site 670487002787 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 670487002788 metal binding site 2 [ion binding]; metal-binding site 670487002789 putative DNA binding helix; other site 670487002790 metal binding site 1 [ion binding]; metal-binding site 670487002791 dimer interface [polypeptide binding]; other site 670487002792 structural Zn2+ binding site [ion binding]; other site 670487002793 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 670487002794 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 670487002795 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 670487002796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 670487002797 Transcriptional regulator; Region: Rrf2; cl17282 670487002798 Rrf2 family protein; Region: rrf2_super; TIGR00738 670487002799 pyruvate phosphate dikinase; Provisional; Region: PRK09279 670487002800 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 670487002801 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 670487002802 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 670487002803 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 670487002804 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 670487002805 acyl-activating enzyme (AAE) consensus motif; other site 670487002806 putative AMP binding site [chemical binding]; other site 670487002807 putative active site [active] 670487002808 putative CoA binding site [chemical binding]; other site 670487002809 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 670487002810 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 670487002811 acyl-activating enzyme (AAE) consensus motif; other site 670487002812 putative AMP binding site [chemical binding]; other site 670487002813 putative active site [active] 670487002814 putative CoA binding site [chemical binding]; other site 670487002815 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 670487002816 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 670487002817 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 670487002818 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 670487002819 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 670487002820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 670487002821 substrate binding site [chemical binding]; other site 670487002822 oxyanion hole (OAH) forming residues; other site 670487002823 trimer interface [polypeptide binding]; other site 670487002824 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 670487002825 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 670487002826 dimer interface [polypeptide binding]; other site 670487002827 active site 670487002828 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 670487002829 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 670487002830 active site 670487002831 acylphosphatase; Provisional; Region: PRK14433 670487002832 Family of unknown function (DUF490); Region: DUF490; pfam04357 670487002833 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 670487002834 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 670487002835 trmE is a tRNA modification GTPase; Region: trmE; cd04164 670487002836 G1 box; other site 670487002837 GTP/Mg2+ binding site [chemical binding]; other site 670487002838 Switch I region; other site 670487002839 G2 box; other site 670487002840 Switch II region; other site 670487002841 G3 box; other site 670487002842 G4 box; other site 670487002843 G5 box; other site 670487002844 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 670487002845 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 670487002846 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 670487002847 inhibitor-cofactor binding pocket; inhibition site 670487002848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487002849 catalytic residue [active] 670487002850 Predicted amidohydrolase [General function prediction only]; Region: COG0388 670487002851 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 670487002852 active site 670487002853 catalytic triad [active] 670487002854 dimer interface [polypeptide binding]; other site 670487002855 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 670487002856 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 670487002857 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 670487002858 catalytic residues [active] 670487002859 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 670487002860 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 670487002861 active site residue [active] 670487002862 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 670487002863 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487002864 catalytic residues [active] 670487002865 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 670487002866 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 670487002867 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 670487002868 ATP binding site [chemical binding]; other site 670487002869 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334 670487002870 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 670487002871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487002872 FeS/SAM binding site; other site 670487002873 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 670487002874 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 670487002875 CTP synthetase; Validated; Region: pyrG; PRK05380 670487002876 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 670487002877 Catalytic site [active] 670487002878 active site 670487002879 UTP binding site [chemical binding]; other site 670487002880 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 670487002881 active site 670487002882 putative oxyanion hole; other site 670487002883 catalytic triad [active] 670487002884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487002885 Walker A motif; other site 670487002886 ATP binding site [chemical binding]; other site 670487002887 Walker B motif; other site 670487002888 arginine finger; other site 670487002889 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 670487002890 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 670487002891 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 670487002892 fumarate hydratase; Reviewed; Region: fumC; PRK00485 670487002893 Class II fumarases; Region: Fumarase_classII; cd01362 670487002894 active site 670487002895 tetramer interface [polypeptide binding]; other site 670487002896 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 670487002897 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 670487002898 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 670487002899 SnoaL-like domain; Region: SnoaL_3; pfam13474 670487002900 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 670487002901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 670487002902 dimerization interface [polypeptide binding]; other site 670487002903 putative DNA binding site [nucleotide binding]; other site 670487002904 Predicted transcriptional regulators [Transcription]; Region: COG1733 670487002905 putative Zn2+ binding site [ion binding]; other site 670487002906 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 670487002907 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 670487002908 propionate/acetate kinase; Provisional; Region: PRK12379 670487002909 Thioredoxin; Region: Thioredoxin_4; pfam13462 670487002910 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 670487002911 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 670487002912 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 670487002913 heterodimer interface [polypeptide binding]; other site 670487002914 active site 670487002915 FMN binding site [chemical binding]; other site 670487002916 homodimer interface [polypeptide binding]; other site 670487002917 substrate binding site [chemical binding]; other site 670487002918 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 670487002919 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 670487002920 FAD binding pocket [chemical binding]; other site 670487002921 FAD binding motif [chemical binding]; other site 670487002922 phosphate binding motif [ion binding]; other site 670487002923 beta-alpha-beta structure motif; other site 670487002924 NAD binding pocket [chemical binding]; other site 670487002925 Iron coordination center [ion binding]; other site 670487002926 dihydroorotase; Validated; Region: pyrC; PRK09357 670487002927 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 670487002928 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 670487002929 active site 670487002930 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 670487002931 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 670487002932 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 670487002933 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 670487002934 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487002935 active site 670487002936 SPW repeat; Region: SPW; pfam03779 670487002937 SPW repeat; Region: SPW; pfam03779 670487002938 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 670487002939 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 670487002940 elongation factor G; Reviewed; Region: PRK12740 670487002941 G1 box; other site 670487002942 putative GEF interaction site [polypeptide binding]; other site 670487002943 GTP/Mg2+ binding site [chemical binding]; other site 670487002944 Switch I region; other site 670487002945 G2 box; other site 670487002946 G3 box; other site 670487002947 Switch II region; other site 670487002948 G4 box; other site 670487002949 G5 box; other site 670487002950 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 670487002951 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 670487002952 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 670487002953 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 670487002954 MPN+ (JAMM) motif; other site 670487002955 Zinc-binding site [ion binding]; other site 670487002956 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 670487002957 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 670487002958 ATP binding site [chemical binding]; other site 670487002959 substrate interface [chemical binding]; other site 670487002960 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 670487002961 dimer interface [polypeptide binding]; other site 670487002962 Citrate synthase; Region: Citrate_synt; pfam00285 670487002963 active site 670487002964 coenzyme A binding site [chemical binding]; other site 670487002965 citrylCoA binding site [chemical binding]; other site 670487002966 oxalacetate/citrate binding site [chemical binding]; other site 670487002967 catalytic triad [active] 670487002968 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 670487002969 Catalytic domain of Protein Kinases; Region: PKc; cd00180 670487002970 active site 670487002971 ATP binding site [chemical binding]; other site 670487002972 substrate binding site [chemical binding]; other site 670487002973 activation loop (A-loop); other site 670487002974 hypothetical protein; Provisional; Region: PRK10279 670487002975 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 670487002976 nucleophile elbow; other site 670487002977 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 670487002978 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 670487002979 Catalytic site [active] 670487002980 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 670487002981 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 670487002982 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 670487002983 inhibitor-cofactor binding pocket; inhibition site 670487002984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487002985 catalytic residue [active] 670487002986 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 670487002987 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 670487002988 Switch I; other site 670487002989 Switch II; other site 670487002990 cell division topological specificity factor MinE; Region: minE; TIGR01215 670487002991 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 670487002992 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 670487002993 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 670487002994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487002995 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 670487002996 Walker A/P-loop; other site 670487002997 ATP binding site [chemical binding]; other site 670487002998 Q-loop/lid; other site 670487002999 ABC transporter signature motif; other site 670487003000 Walker B; other site 670487003001 D-loop; other site 670487003002 H-loop/switch region; other site 670487003003 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 670487003004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487003005 dimer interface [polypeptide binding]; other site 670487003006 conserved gate region; other site 670487003007 putative PBP binding loops; other site 670487003008 ABC-ATPase subunit interface; other site 670487003009 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 670487003010 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 670487003011 Cytochrome c; Region: Cytochrom_C; pfam00034 670487003012 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487003013 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 670487003014 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 670487003015 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 670487003016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487003017 dimer interface [polypeptide binding]; other site 670487003018 conserved gate region; other site 670487003019 putative PBP binding loops; other site 670487003020 ABC-ATPase subunit interface; other site 670487003021 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 670487003022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487003023 dimer interface [polypeptide binding]; other site 670487003024 conserved gate region; other site 670487003025 putative PBP binding loops; other site 670487003026 ABC-ATPase subunit interface; other site 670487003027 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 670487003028 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 670487003029 Walker A/P-loop; other site 670487003030 ATP binding site [chemical binding]; other site 670487003031 Q-loop/lid; other site 670487003032 ABC transporter signature motif; other site 670487003033 Walker B; other site 670487003034 D-loop; other site 670487003035 H-loop/switch region; other site 670487003036 TOBE domain; Region: TOBE_2; pfam08402 670487003037 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 670487003038 active site 670487003039 putative DNA-binding cleft [nucleotide binding]; other site 670487003040 dimer interface [polypeptide binding]; other site 670487003041 hypothetical protein; Validated; Region: PRK00110 670487003042 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 670487003043 Threonine dehydrogenase; Region: TDH; cd05281 670487003044 structural Zn binding site [ion binding]; other site 670487003045 catalytic Zn binding site [ion binding]; other site 670487003046 tetramer interface [polypeptide binding]; other site 670487003047 NADP binding site [chemical binding]; other site 670487003048 comF family protein; Region: comF; TIGR00201 670487003049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487003050 active site 670487003051 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 670487003052 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 670487003053 active site residue [active] 670487003054 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 670487003055 thiosulfate reductase PhsA; Provisional; Region: PRK15488 670487003056 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 670487003057 putative [Fe4-S4] binding site [ion binding]; other site 670487003058 putative molybdopterin cofactor binding site [chemical binding]; other site 670487003059 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487003060 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 670487003061 putative molybdopterin cofactor binding site; other site 670487003062 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 670487003063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 670487003064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487003065 active site 670487003066 phosphorylation site [posttranslational modification] 670487003067 intermolecular recognition site; other site 670487003068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 670487003069 DNA binding residues [nucleotide binding] 670487003070 dimerization interface [polypeptide binding]; other site 670487003071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 670487003072 Histidine kinase; Region: HisKA_3; pfam07730 670487003073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487003074 ATP binding site [chemical binding]; other site 670487003075 Mg2+ binding site [ion binding]; other site 670487003076 G-X-G motif; other site 670487003077 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 670487003078 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 670487003079 active site 670487003080 Riboflavin kinase; Region: Flavokinase; pfam01687 670487003081 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 670487003082 dimer interface [polypeptide binding]; other site 670487003083 ADP-ribose binding site [chemical binding]; other site 670487003084 active site 670487003085 nudix motif; other site 670487003086 metal binding site [ion binding]; metal-binding site 670487003087 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 670487003088 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 670487003089 active site 670487003090 GAF domain; Region: GAF_3; pfam13492 670487003091 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487003092 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487003093 metal binding site [ion binding]; metal-binding site 670487003094 active site 670487003095 I-site; other site 670487003096 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 670487003097 DEAD/DEAH box helicase; Region: DEAD; pfam00270 670487003098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 670487003099 nucleotide binding region [chemical binding]; other site 670487003100 ATP-binding site [chemical binding]; other site 670487003101 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 670487003102 Domain of unknown function DUF59; Region: DUF59; pfam01883 670487003103 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 670487003104 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 670487003105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 670487003106 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603 670487003107 RuvA N terminal domain; Region: RuvA_N; pfam01330 670487003108 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 670487003109 Prephenate dehydratase; Region: PDT; pfam00800 670487003110 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 670487003111 putative L-Phe binding site [chemical binding]; other site 670487003112 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 670487003113 Protein of unknown function (DUF3234); Region: DUF3234; pfam11572 670487003114 Dodecin; Region: Dodecin; pfam07311 670487003115 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 670487003116 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 670487003117 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 670487003118 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 670487003119 motif 1; other site 670487003120 dimer interface [polypeptide binding]; other site 670487003121 active site 670487003122 motif 2; other site 670487003123 motif 3; other site 670487003124 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 670487003125 Clp amino terminal domain; Region: Clp_N; pfam02861 670487003126 Clp amino terminal domain; Region: Clp_N; pfam02861 670487003127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487003128 Walker A motif; other site 670487003129 ATP binding site [chemical binding]; other site 670487003130 Walker B motif; other site 670487003131 arginine finger; other site 670487003132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487003133 Walker A motif; other site 670487003134 ATP binding site [chemical binding]; other site 670487003135 Walker B motif; other site 670487003136 arginine finger; other site 670487003137 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 670487003138 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 670487003139 AAA domain; Region: AAA_25; pfam13481 670487003140 Walker A motif; other site 670487003141 ATP binding site [chemical binding]; other site 670487003142 Walker B motif; other site 670487003143 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 670487003144 putative active site [active] 670487003145 PspC domain; Region: PspC; pfam04024 670487003146 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 670487003147 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 670487003148 CoA-ligase; Region: Ligase_CoA; pfam00549 670487003149 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 670487003150 CoA binding domain; Region: CoA_binding; smart00881 670487003151 CoA-ligase; Region: Ligase_CoA; pfam00549 670487003152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 670487003153 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 670487003154 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 670487003155 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 670487003156 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 670487003157 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 670487003158 FOG: CBS domain [General function prediction only]; Region: COG0517 670487003159 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 670487003160 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 670487003161 Cupin domain; Region: Cupin_2; pfam07883 670487003162 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 670487003163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 670487003164 nucleotide binding site [chemical binding]; other site 670487003165 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 670487003166 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 670487003167 ligand binding site [chemical binding]; other site 670487003168 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487003169 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 670487003170 TM-ABC transporter signature motif; other site 670487003171 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 670487003172 TM-ABC transporter signature motif; other site 670487003173 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 670487003174 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 670487003175 Walker A/P-loop; other site 670487003176 ATP binding site [chemical binding]; other site 670487003177 Q-loop/lid; other site 670487003178 ABC transporter signature motif; other site 670487003179 Walker B; other site 670487003180 D-loop; other site 670487003181 H-loop/switch region; other site 670487003182 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 670487003183 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 670487003184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 670487003185 DNA binding residues [nucleotide binding] 670487003186 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 670487003187 OstA-like protein; Region: OstA; cl00844 670487003188 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 670487003189 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 670487003190 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 670487003191 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 670487003192 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 670487003193 dimer interface [polypeptide binding]; other site 670487003194 putative anticodon binding site; other site 670487003195 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 670487003196 motif 1; other site 670487003197 active site 670487003198 motif 2; other site 670487003199 motif 3; other site 670487003200 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 670487003201 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 670487003202 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 670487003203 ferrochelatase; Provisional; Region: PRK12435 670487003204 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 670487003205 active site 670487003206 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 670487003207 active site 670487003208 N-terminal domain interface [polypeptide binding]; other site 670487003209 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 670487003210 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 670487003211 substrate binding site [chemical binding]; other site 670487003212 active site 670487003213 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 670487003214 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 670487003215 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 670487003216 NAD(P) binding site [chemical binding]; other site 670487003217 shikimate binding site; other site 670487003218 hypothetical protein; Provisional; Region: PRK04164 670487003219 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 670487003220 Uncharacterized conserved protein [Function unknown]; Region: COG1739 670487003221 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 670487003222 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 670487003223 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 670487003224 DNA polymerase I; Region: pola; TIGR00593 670487003225 active site 670487003226 metal binding site 1 [ion binding]; metal-binding site 670487003227 putative 5' ssDNA interaction site; other site 670487003228 metal binding site 3; metal-binding site 670487003229 metal binding site 2 [ion binding]; metal-binding site 670487003230 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 670487003231 putative DNA binding site [nucleotide binding]; other site 670487003232 putative metal binding site [ion binding]; other site 670487003233 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 670487003234 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 670487003235 active site 670487003236 DNA binding site [nucleotide binding] 670487003237 catalytic site [active] 670487003238 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323 670487003239 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 670487003240 active site 670487003241 substrate binding site [chemical binding]; other site 670487003242 metal binding site [ion binding]; metal-binding site 670487003243 Ribosome-binding factor A; Region: RBFA; pfam02033 670487003244 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 670487003245 active site 670487003246 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 670487003247 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 670487003248 inhibitor-cofactor binding pocket; inhibition site 670487003249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487003250 catalytic residue [active] 670487003251 ribonuclease R; Region: RNase_R; TIGR02063 670487003252 Replication protein A C terminal; Region: RPA_C; pfam08784 670487003253 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 670487003254 RNB domain; Region: RNB; pfam00773 670487003255 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 670487003256 RNA binding site [nucleotide binding]; other site 670487003257 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 670487003258 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 670487003259 dimer interface [polypeptide binding]; other site 670487003260 PYR/PP interface [polypeptide binding]; other site 670487003261 TPP binding site [chemical binding]; other site 670487003262 substrate binding site [chemical binding]; other site 670487003263 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 670487003264 4Fe-4S binding domain; Region: Fer4; pfam00037 670487003265 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 670487003266 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 670487003267 TPP-binding site [chemical binding]; other site 670487003268 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 670487003269 FAD binding site [chemical binding]; other site 670487003270 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 670487003271 putative active site [active] 670487003272 dimerization interface [polypeptide binding]; other site 670487003273 putative tRNAtyr binding site [nucleotide binding]; other site 670487003274 EDD domain protein, DegV family; Region: DegV; TIGR00762 670487003275 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 670487003276 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 670487003277 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 670487003278 ligand binding site [chemical binding]; other site 670487003279 NAD binding site [chemical binding]; other site 670487003280 dimerization interface [polypeptide binding]; other site 670487003281 catalytic site [active] 670487003282 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 670487003283 putative L-serine binding site [chemical binding]; other site 670487003284 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 670487003285 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 670487003286 catalytic residue [active] 670487003287 Protein of unknown function (DUF436); Region: DUF436; cl01860 670487003288 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 670487003289 homotrimer interaction site [polypeptide binding]; other site 670487003290 active site 670487003291 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 670487003292 Cl- selectivity filter; other site 670487003293 Cl- binding residues [ion binding]; other site 670487003294 pore gating glutamate residue; other site 670487003295 TrkA-C domain; Region: TrkA_C; pfam02080 670487003296 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 670487003297 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 670487003298 active site 670487003299 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 670487003300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487003301 FeS/SAM binding site; other site 670487003302 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 670487003303 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 670487003304 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487003305 catalytic triad [active] 670487003306 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 670487003307 tetramer (dimer of dimers) interface [polypeptide binding]; other site 670487003308 active site 670487003309 dimer interface [polypeptide binding]; other site 670487003310 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 670487003311 ArsC family; Region: ArsC; pfam03960 670487003312 catalytic residue [active] 670487003313 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 670487003314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487003315 Walker A/P-loop; other site 670487003316 ATP binding site [chemical binding]; other site 670487003317 Q-loop/lid; other site 670487003318 ABC transporter signature motif; other site 670487003319 Walker B; other site 670487003320 D-loop; other site 670487003321 H-loop/switch region; other site 670487003322 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 670487003323 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 670487003324 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 670487003325 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 670487003326 active site 670487003327 HIGH motif; other site 670487003328 KMSKS motif; other site 670487003329 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 670487003330 anticodon binding site; other site 670487003331 tRNA binding surface [nucleotide binding]; other site 670487003332 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 670487003333 dimer interface [polypeptide binding]; other site 670487003334 putative tRNA-binding site [nucleotide binding]; other site 670487003335 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 670487003336 active site 670487003337 metal binding site [ion binding]; metal-binding site 670487003338 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 670487003339 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 670487003340 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 670487003341 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487003342 Zn2+ binding site [ion binding]; other site 670487003343 Mg2+ binding site [ion binding]; other site 670487003344 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 670487003345 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 670487003346 CoA-binding site [chemical binding]; other site 670487003347 ATP-binding [chemical binding]; other site 670487003348 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 670487003349 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 670487003350 intersubunit interface [polypeptide binding]; other site 670487003351 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 670487003352 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 670487003353 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 670487003354 Ligand binding site; other site 670487003355 Putative Catalytic site; other site 670487003356 DXD motif; other site 670487003357 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 670487003358 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 670487003359 active site 670487003360 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 670487003361 protein binding site [polypeptide binding]; other site 670487003362 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 670487003363 putative substrate binding region [chemical binding]; other site 670487003364 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 670487003365 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 670487003366 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 670487003367 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 670487003368 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 670487003369 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 670487003370 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 670487003371 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 670487003372 catalytic residue [active] 670487003373 putative FPP diphosphate binding site; other site 670487003374 putative FPP binding hydrophobic cleft; other site 670487003375 dimer interface [polypeptide binding]; other site 670487003376 putative IPP diphosphate binding site; other site 670487003377 ribosome recycling factor; Reviewed; Region: frr; PRK00083 670487003378 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 670487003379 hinge region; other site 670487003380 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 670487003381 putative nucleotide binding site [chemical binding]; other site 670487003382 uridine monophosphate binding site [chemical binding]; other site 670487003383 homohexameric interface [polypeptide binding]; other site 670487003384 elongation factor Ts; Reviewed; Region: tsf; PRK12332 670487003385 UBA/TS-N domain; Region: UBA; pfam00627 670487003386 Elongation factor TS; Region: EF_TS; pfam00889 670487003387 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 670487003388 rRNA interaction site [nucleotide binding]; other site 670487003389 S8 interaction site; other site 670487003390 putative laminin-1 binding site; other site 670487003391 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 670487003392 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487003393 molybdopterin cofactor binding site; other site 670487003394 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487003395 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487003396 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 670487003397 molybdopterin cofactor binding site; other site 670487003398 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 670487003399 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 670487003400 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 670487003401 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 670487003402 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 670487003403 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 670487003404 GTP binding site; other site 670487003405 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 670487003406 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 670487003407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487003408 catalytic residue [active] 670487003409 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 670487003410 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 670487003411 substrate binding site [chemical binding]; other site 670487003412 active site 670487003413 catalytic residues [active] 670487003414 heterodimer interface [polypeptide binding]; other site 670487003415 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 670487003416 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 670487003417 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 670487003418 active site 670487003419 octamer interface [polypeptide binding]; other site 670487003420 DctM-like transporters; Region: DctM; pfam06808 670487003421 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 670487003422 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 670487003423 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 670487003424 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 670487003425 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 670487003426 putative active site [active] 670487003427 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 670487003428 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 670487003429 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 670487003430 endonuclease IV; Provisional; Region: PRK01060 670487003431 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 670487003432 AP (apurinic/apyrimidinic) site pocket; other site 670487003433 DNA interaction; other site 670487003434 Metal-binding active site; metal-binding site 670487003435 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 670487003436 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 670487003437 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 670487003438 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 670487003439 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 670487003440 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 670487003441 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 670487003442 active site 670487003443 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 670487003444 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 670487003445 putative dimer interface [polypeptide binding]; other site 670487003446 putative anticodon binding site; other site 670487003447 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 670487003448 homodimer interface [polypeptide binding]; other site 670487003449 motif 1; other site 670487003450 motif 2; other site 670487003451 active site 670487003452 motif 3; other site 670487003453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 670487003454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 670487003455 salt bridge; other site 670487003456 non-specific DNA binding site [nucleotide binding]; other site 670487003457 sequence-specific DNA binding site [nucleotide binding]; other site 670487003458 Predicted transporter component [General function prediction only]; Region: COG2391 670487003459 Sulphur transport; Region: Sulf_transp; pfam04143 670487003460 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 670487003461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487003462 active site 670487003463 motif I; other site 670487003464 motif II; other site 670487003465 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 670487003466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487003467 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 670487003468 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 670487003469 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 670487003470 dimer interface [polypeptide binding]; other site 670487003471 anticodon binding site; other site 670487003472 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 670487003473 homodimer interface [polypeptide binding]; other site 670487003474 motif 1; other site 670487003475 active site 670487003476 motif 2; other site 670487003477 GAD domain; Region: GAD; pfam02938 670487003478 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 670487003479 motif 3; other site 670487003480 histidyl-tRNA synthetase; Region: hisS; TIGR00442 670487003481 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 670487003482 dimer interface [polypeptide binding]; other site 670487003483 motif 1; other site 670487003484 active site 670487003485 motif 2; other site 670487003486 motif 3; other site 670487003487 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 670487003488 anticodon binding site; other site 670487003489 Predicted membrane protein [Function unknown]; Region: COG3374 670487003490 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 670487003491 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 670487003492 active site 670487003493 DNA binding site [nucleotide binding] 670487003494 Int/Topo IB signature motif; other site 670487003495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 670487003496 calcium/proton exchanger (cax); Region: cax; TIGR00378 670487003497 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 670487003498 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 670487003499 Walker A/P-loop; other site 670487003500 ATP binding site [chemical binding]; other site 670487003501 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 670487003502 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 670487003503 ABC transporter signature motif; other site 670487003504 Walker B; other site 670487003505 D-loop; other site 670487003506 H-loop/switch region; other site 670487003507 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 670487003508 metal binding site [ion binding]; metal-binding site 670487003509 Sporulation and spore germination; Region: Germane; pfam10646 670487003510 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 670487003511 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 670487003512 active site 670487003513 metal binding site [ion binding]; metal-binding site 670487003514 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 670487003515 SmpB-tmRNA interface; other site 670487003516 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 670487003517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487003518 dimer interface [polypeptide binding]; other site 670487003519 conserved gate region; other site 670487003520 putative PBP binding loops; other site 670487003521 ABC-ATPase subunit interface; other site 670487003522 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487003523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487003524 dimer interface [polypeptide binding]; other site 670487003525 conserved gate region; other site 670487003526 putative PBP binding loops; other site 670487003527 ABC-ATPase subunit interface; other site 670487003528 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 670487003529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 670487003530 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 670487003531 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 670487003532 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 670487003533 Phosphoglycerate kinase; Region: PGK; pfam00162 670487003534 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 670487003535 substrate binding site [chemical binding]; other site 670487003536 hinge regions; other site 670487003537 ADP binding site [chemical binding]; other site 670487003538 catalytic site [active] 670487003539 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 670487003540 triosephosphate isomerase; Provisional; Region: PRK14565 670487003541 substrate binding site [chemical binding]; other site 670487003542 dimer interface [polypeptide binding]; other site 670487003543 catalytic triad [active] 670487003544 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 670487003545 predicted active site [active] 670487003546 catalytic triad [active] 670487003547 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 670487003548 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 670487003549 active site 670487003550 multimer interface [polypeptide binding]; other site 670487003551 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 670487003552 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 670487003553 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 670487003554 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 670487003555 Peptidase family M23; Region: Peptidase_M23; pfam01551 670487003556 transcription termination factor Rho; Provisional; Region: rho; PRK09376 670487003557 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 670487003558 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 670487003559 RNA binding site [nucleotide binding]; other site 670487003560 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 670487003561 Walker A motif; other site 670487003562 ATP binding site [chemical binding]; other site 670487003563 Walker B motif; other site 670487003564 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 670487003565 active site 670487003566 intersubunit interactions; other site 670487003567 catalytic residue [active] 670487003568 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 670487003569 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 670487003570 HIGH motif; other site 670487003571 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 670487003572 active site 670487003573 KMSKS motif; other site 670487003574 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 670487003575 tRNA binding surface [nucleotide binding]; other site 670487003576 anticodon binding site; other site 670487003577 Peptidase family M50; Region: Peptidase_M50; pfam02163 670487003578 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 670487003579 active site 670487003580 putative substrate binding region [chemical binding]; other site 670487003581 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 670487003582 active site 670487003583 putative substrate binding region [chemical binding]; other site 670487003584 DHH family; Region: DHH; pfam01368 670487003585 FOG: CBS domain [General function prediction only]; Region: COG0517 670487003586 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 670487003587 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 670487003588 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 670487003589 active site 670487003590 NTP binding site [chemical binding]; other site 670487003591 metal binding triad [ion binding]; metal-binding site 670487003592 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 670487003593 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 670487003594 DEAD-like helicases superfamily; Region: DEXDc; smart00487 670487003595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 670487003596 ATP binding site [chemical binding]; other site 670487003597 putative Mg++ binding site [ion binding]; other site 670487003598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 670487003599 nucleotide binding region [chemical binding]; other site 670487003600 ATP-binding site [chemical binding]; other site 670487003601 TRCF domain; Region: TRCF; pfam03461 670487003602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 670487003603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487003604 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 670487003605 Protein of unknown function (DUF554); Region: DUF554; pfam04474 670487003606 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 670487003607 seryl-tRNA synthetase; Provisional; Region: PRK05431 670487003608 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 670487003609 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 670487003610 dimer interface [polypeptide binding]; other site 670487003611 active site 670487003612 motif 1; other site 670487003613 motif 2; other site 670487003614 motif 3; other site 670487003615 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 670487003616 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 670487003617 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 670487003618 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 670487003619 NAD(P) binding site [chemical binding]; other site 670487003620 catalytic residues [active] 670487003621 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 670487003622 hypothetical protein; Provisional; Region: PRK08201 670487003623 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 670487003624 metal binding site [ion binding]; metal-binding site 670487003625 putative dimer interface [polypeptide binding]; other site 670487003626 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 670487003627 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 670487003628 DNA binding residues [nucleotide binding] 670487003629 putative dimer interface [polypeptide binding]; other site 670487003630 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 670487003631 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 670487003632 DNA binding residues [nucleotide binding] 670487003633 putative dimer interface [polypeptide binding]; other site 670487003634 malate dehydrogenase; Provisional; Region: PRK13529 670487003635 Malic enzyme, N-terminal domain; Region: malic; pfam00390 670487003636 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 670487003637 NAD(P) binding site [chemical binding]; other site 670487003638 malate dehydrogenase; Reviewed; Region: PRK06223 670487003639 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 670487003640 NAD(P) binding site [chemical binding]; other site 670487003641 dimer interface [polypeptide binding]; other site 670487003642 tetramer (dimer of dimers) interface [polypeptide binding]; other site 670487003643 substrate binding site [chemical binding]; other site 670487003644 enoyl-CoA hydratase; Provisional; Region: PRK08140 670487003645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 670487003646 substrate binding site [chemical binding]; other site 670487003647 oxyanion hole (OAH) forming residues; other site 670487003648 trimer interface [polypeptide binding]; other site 670487003649 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 670487003650 heme-binding site [chemical binding]; other site 670487003651 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 670487003652 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 670487003653 active site 670487003654 dimer interface [polypeptide binding]; other site 670487003655 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 670487003656 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 670487003657 active site 670487003658 FMN binding site [chemical binding]; other site 670487003659 substrate binding site [chemical binding]; other site 670487003660 3Fe-4S cluster binding site [ion binding]; other site 670487003661 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 670487003662 domain interface; other site 670487003663 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 670487003664 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 670487003665 16S rRNA methyltransferase B; Provisional; Region: PRK14902 670487003666 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 670487003667 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 670487003668 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 670487003669 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 670487003670 active site 670487003671 HIGH motif; other site 670487003672 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 670487003673 KMSKS motif; other site 670487003674 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 670487003675 tRNA binding surface [nucleotide binding]; other site 670487003676 anticodon binding site; other site 670487003677 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 670487003678 hydrophobic ligand binding site; other site 670487003679 recombination regulator RecX; Reviewed; Region: recX; PRK00117 670487003680 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 670487003681 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 670487003682 active site 670487003683 metal binding site [ion binding]; metal-binding site 670487003684 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 670487003685 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 670487003686 TilS substrate C-terminal domain; Region: TilS_C; smart00977 670487003687 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 670487003688 nucleoside/Zn binding site; other site 670487003689 dimer interface [polypeptide binding]; other site 670487003690 catalytic motif [active] 670487003691 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 670487003692 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 670487003693 Permutation of conserved domain; other site 670487003694 active site 670487003695 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 670487003696 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 670487003697 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 670487003698 Cl- selectivity filter; other site 670487003699 Cl- binding residues [ion binding]; other site 670487003700 pore gating glutamate residue; other site 670487003701 dimer interface [polypeptide binding]; other site 670487003702 TrkA-C domain; Region: TrkA_C; pfam02080 670487003703 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 670487003704 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 670487003705 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 670487003706 CoenzymeA binding site [chemical binding]; other site 670487003707 subunit interaction site [polypeptide binding]; other site 670487003708 PHB binding site; other site 670487003709 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 670487003710 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 670487003711 prephenate dehydrogenase; Validated; Region: PRK08507 670487003712 prephenate dehydrogenase; Validated; Region: PRK06545 670487003713 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 670487003714 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 670487003715 Ligand Binding Site [chemical binding]; other site 670487003716 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 670487003717 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 670487003718 dimer interface [polypeptide binding]; other site 670487003719 active site residues [active] 670487003720 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 670487003721 hypothetical protein; Provisional; Region: PRK13665 670487003722 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 670487003723 PhoH-like protein; Region: PhoH; pfam02562 670487003724 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 670487003725 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 670487003726 Domain of unknown function DUF21; Region: DUF21; pfam01595 670487003727 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 670487003728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 670487003729 Transporter associated domain; Region: CorC_HlyC; smart01091 670487003730 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 670487003731 active site 670487003732 catalytic motif [active] 670487003733 Zn binding site [ion binding]; other site 670487003734 Methyltransferase domain; Region: Methyltransf_23; pfam13489 670487003735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487003736 S-adenosylmethionine binding site [chemical binding]; other site 670487003737 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 670487003738 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 670487003739 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 670487003740 inhibitor site; inhibition site 670487003741 active site 670487003742 dimer interface [polypeptide binding]; other site 670487003743 catalytic residue [active] 670487003744 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 670487003745 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 670487003746 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 670487003747 putative L-serine binding site [chemical binding]; other site 670487003748 Predicted transcriptional regulators [Transcription]; Region: COG1510 670487003749 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 670487003750 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 670487003751 FtsX-like permease family; Region: FtsX; pfam02687 670487003752 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 670487003753 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 670487003754 FtsX-like permease family; Region: FtsX; pfam02687 670487003755 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 670487003756 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 670487003757 Walker A/P-loop; other site 670487003758 ATP binding site [chemical binding]; other site 670487003759 Q-loop/lid; other site 670487003760 ABC transporter signature motif; other site 670487003761 Walker B; other site 670487003762 D-loop; other site 670487003763 H-loop/switch region; other site 670487003764 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 670487003765 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 670487003766 Walker A/P-loop; other site 670487003767 ATP binding site [chemical binding]; other site 670487003768 Q-loop/lid; other site 670487003769 ABC transporter signature motif; other site 670487003770 Walker B; other site 670487003771 D-loop; other site 670487003772 H-loop/switch region; other site 670487003773 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 670487003774 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 670487003775 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 670487003776 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 670487003777 TM-ABC transporter signature motif; other site 670487003778 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487003779 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 670487003780 TM-ABC transporter signature motif; other site 670487003781 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 670487003782 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 670487003783 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 670487003784 acyl-activating enzyme (AAE) consensus motif; other site 670487003785 putative AMP binding site [chemical binding]; other site 670487003786 putative active site [active] 670487003787 putative CoA binding site [chemical binding]; other site 670487003788 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 670487003789 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 670487003790 Walker A/P-loop; other site 670487003791 ATP binding site [chemical binding]; other site 670487003792 Q-loop/lid; other site 670487003793 ABC transporter signature motif; other site 670487003794 Walker B; other site 670487003795 D-loop; other site 670487003796 H-loop/switch region; other site 670487003797 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 670487003798 active site 670487003799 ribulose/triose binding site [chemical binding]; other site 670487003800 phosphate binding site [ion binding]; other site 670487003801 substrate (anthranilate) binding pocket [chemical binding]; other site 670487003802 product (indole) binding pocket [chemical binding]; other site 670487003803 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 670487003804 catalytic nucleophile [active] 670487003805 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 670487003806 Part of AAA domain; Region: AAA_19; pfam13245 670487003807 Family description; Region: UvrD_C_2; pfam13538 670487003808 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 670487003809 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 670487003810 active site 670487003811 substrate binding site [chemical binding]; other site 670487003812 metal binding site [ion binding]; metal-binding site 670487003813 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 670487003814 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 670487003815 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 670487003816 TPP-binding site [chemical binding]; other site 670487003817 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 670487003818 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 670487003819 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 670487003820 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 670487003821 dimer interface [polypeptide binding]; other site 670487003822 PYR/PP interface [polypeptide binding]; other site 670487003823 TPP binding site [chemical binding]; other site 670487003824 substrate binding site [chemical binding]; other site 670487003825 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 670487003826 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 670487003827 active site 670487003828 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 670487003829 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 670487003830 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 670487003831 Ligand Binding Site [chemical binding]; other site 670487003832 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 670487003833 PLD-like domain; Region: PLDc_2; pfam13091 670487003834 putative active site [active] 670487003835 putative catalytic site [active] 670487003836 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 670487003837 PLD-like domain; Region: PLDc_2; pfam13091 670487003838 putative active site [active] 670487003839 putative catalytic site [active] 670487003840 OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336 670487003841 generic binding surface II; other site 670487003842 generic binding surface I; other site 670487003843 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 670487003844 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 670487003845 Dimer interface [polypeptide binding]; other site 670487003846 anticodon binding site; other site 670487003847 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 670487003848 homodimer interface [polypeptide binding]; other site 670487003849 motif 1; other site 670487003850 motif 2; other site 670487003851 active site 670487003852 motif 3; other site 670487003853 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 670487003854 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 670487003855 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 670487003856 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 670487003857 Walker A/P-loop; other site 670487003858 ATP binding site [chemical binding]; other site 670487003859 Q-loop/lid; other site 670487003860 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 670487003861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487003862 ABC transporter signature motif; other site 670487003863 Walker B; other site 670487003864 D-loop; other site 670487003865 H-loop/switch region; other site 670487003866 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 670487003867 active site 670487003868 metal binding site [ion binding]; metal-binding site 670487003869 DNA binding site [nucleotide binding] 670487003870 HerA helicase [Replication, recombination, and repair]; Region: COG0433 670487003871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 670487003872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487003873 binding surface 670487003874 TPR repeat; Region: TPR_11; pfam13414 670487003875 TPR motif; other site 670487003876 Tetratricopeptide repeat; Region: TPR_12; pfam13424 670487003877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487003878 binding surface 670487003879 TPR repeat; Region: TPR_11; pfam13414 670487003880 TPR motif; other site 670487003881 TPR repeat; Region: TPR_11; pfam13414 670487003882 TPR repeat; Region: TPR_11; pfam13414 670487003883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487003884 binding surface 670487003885 TPR motif; other site 670487003886 TPR repeat; Region: TPR_11; pfam13414 670487003887 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 670487003888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487003889 Walker A motif; other site 670487003890 ATP binding site [chemical binding]; other site 670487003891 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 670487003892 Walker B motif; other site 670487003893 arginine finger; other site 670487003894 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 670487003895 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 670487003896 active site 670487003897 HslU subunit interaction site [polypeptide binding]; other site 670487003898 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 670487003899 Glucose inhibited division protein A; Region: GIDA; pfam01134 670487003900 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 670487003901 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 670487003902 Walker A/P-loop; other site 670487003903 ATP binding site [chemical binding]; other site 670487003904 Q-loop/lid; other site 670487003905 ABC transporter signature motif; other site 670487003906 Walker B; other site 670487003907 D-loop; other site 670487003908 H-loop/switch region; other site 670487003909 TOBE domain; Region: TOBE_2; pfam08402 670487003910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 670487003911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 670487003912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487003913 dimer interface [polypeptide binding]; other site 670487003914 phosphorylation site [posttranslational modification] 670487003915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487003916 ATP binding site [chemical binding]; other site 670487003917 Mg2+ binding site [ion binding]; other site 670487003918 G-X-G motif; other site 670487003919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 670487003920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487003921 active site 670487003922 phosphorylation site [posttranslational modification] 670487003923 intermolecular recognition site; other site 670487003924 dimerization interface [polypeptide binding]; other site 670487003925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 670487003926 DNA binding residues [nucleotide binding] 670487003927 dimerization interface [polypeptide binding]; other site 670487003928 Protein of unknown function (DUF970); Region: DUF970; cl17525 670487003929 Thioredoxin; Region: Thioredoxin_4; pfam13462 670487003930 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 670487003931 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 670487003932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487003933 S-adenosylmethionine binding site [chemical binding]; other site 670487003934 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 670487003935 Domain of unknown function (DUF814); Region: DUF814; pfam05670 670487003936 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 670487003937 tetramerization interface [polypeptide binding]; other site 670487003938 active site 670487003939 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 670487003940 UbiA prenyltransferase family; Region: UbiA; pfam01040 670487003941 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 670487003942 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 670487003943 dimerization interface [polypeptide binding]; other site 670487003944 domain crossover interface; other site 670487003945 redox-dependent activation switch; other site 670487003946 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 670487003947 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 670487003948 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 670487003949 active site 670487003950 (T/H)XGH motif; other site 670487003951 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 670487003952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487003953 S-adenosylmethionine binding site [chemical binding]; other site 670487003954 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 670487003955 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 670487003956 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 670487003957 PhoU domain; Region: PhoU; pfam01895 670487003958 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 670487003959 Found in ATP-dependent protease La (LON); Region: LON; smart00464 670487003960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487003961 Walker A motif; other site 670487003962 ATP binding site [chemical binding]; other site 670487003963 Walker B motif; other site 670487003964 arginine finger; other site 670487003965 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 670487003966 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 670487003967 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 670487003968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487003969 Walker A motif; other site 670487003970 ATP binding site [chemical binding]; other site 670487003971 Walker B motif; other site 670487003972 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 670487003973 Clp protease; Region: CLP_protease; pfam00574 670487003974 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 670487003975 oligomer interface [polypeptide binding]; other site 670487003976 active site residues [active] 670487003977 trigger factor; Region: tig; TIGR00115 670487003978 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 670487003979 CAAX protease self-immunity; Region: Abi; pfam02517 670487003980 isocitrate dehydrogenase; Validated; Region: PRK07362 670487003981 isocitrate dehydrogenase; Reviewed; Region: PRK07006 670487003982 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 670487003983 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 670487003984 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 670487003985 dimer interface [polypeptide binding]; other site 670487003986 active site 670487003987 ADP-ribose binding site [chemical binding]; other site 670487003988 nudix motif; other site 670487003989 metal binding site [ion binding]; metal-binding site 670487003990 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 670487003991 MraZ protein; Region: MraZ; pfam02381 670487003992 cell division protein MraZ; Reviewed; Region: PRK00326 670487003993 MraZ protein; Region: MraZ; pfam02381 670487003994 MraW methylase family; Region: Methyltransf_5; cl17771 670487003995 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 670487003996 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 670487003997 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 670487003998 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 670487003999 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 670487004000 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 670487004001 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 670487004002 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655 670487004003 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 670487004004 Mg++ binding site [ion binding]; other site 670487004005 putative catalytic motif [active] 670487004006 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 670487004007 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 670487004008 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 670487004009 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 670487004010 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 670487004011 active site 670487004012 homodimer interface [polypeptide binding]; other site 670487004013 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 670487004014 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 670487004015 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 670487004016 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651 670487004017 FAD binding domain; Region: FAD_binding_4; pfam01565 670487004018 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 670487004019 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 670487004020 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 670487004021 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 670487004022 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 670487004023 nucleotide binding site [chemical binding]; other site 670487004024 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 670487004025 Cell division protein FtsA; Region: FtsA; pfam14450 670487004026 cell division protein FtsZ; Validated; Region: PRK09330 670487004027 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 670487004028 nucleotide binding site [chemical binding]; other site 670487004029 SulA interaction site; other site 670487004030 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 670487004031 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 670487004032 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 670487004033 SEC-C motif; Region: SEC-C; pfam02810 670487004034 UGMP family protein; Validated; Region: PRK09604 670487004035 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 670487004036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 670487004037 Methyltransferase domain; Region: Methyltransf_31; pfam13847 670487004038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487004039 S-adenosylmethionine binding site [chemical binding]; other site 670487004040 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 670487004041 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 670487004042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 670487004043 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 670487004044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 670487004045 DNA binding residues [nucleotide binding] 670487004046 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 670487004047 TAP-like protein; Region: Abhydrolase_4; pfam08386 670487004048 ornithine cyclodeaminase; Validated; Region: PRK07340 670487004049 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 670487004050 NAD(P) binding site [chemical binding]; other site 670487004051 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 670487004052 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 670487004053 Walker A/P-loop; other site 670487004054 ATP binding site [chemical binding]; other site 670487004055 Q-loop/lid; other site 670487004056 ABC transporter signature motif; other site 670487004057 Walker B; other site 670487004058 D-loop; other site 670487004059 H-loop/switch region; other site 670487004060 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 670487004061 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 670487004062 active site 670487004063 nucleophile elbow; other site 670487004064 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 670487004065 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 670487004066 Walker A/P-loop; other site 670487004067 ATP binding site [chemical binding]; other site 670487004068 Q-loop/lid; other site 670487004069 ABC transporter signature motif; other site 670487004070 Walker B; other site 670487004071 D-loop; other site 670487004072 H-loop/switch region; other site 670487004073 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 670487004074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487004075 dimer interface [polypeptide binding]; other site 670487004076 conserved gate region; other site 670487004077 putative PBP binding loops; other site 670487004078 ABC-ATPase subunit interface; other site 670487004079 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 670487004080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 670487004081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487004082 putative PBP binding loops; other site 670487004083 dimer interface [polypeptide binding]; other site 670487004084 ABC-ATPase subunit interface; other site 670487004085 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 670487004086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 670487004087 substrate binding pocket [chemical binding]; other site 670487004088 membrane-bound complex binding site; other site 670487004089 hinge residues; other site 670487004090 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 670487004091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487004092 dimer interface [polypeptide binding]; other site 670487004093 conserved gate region; other site 670487004094 putative PBP binding loops; other site 670487004095 ABC-ATPase subunit interface; other site 670487004096 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 670487004097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 670487004098 substrate binding pocket [chemical binding]; other site 670487004099 membrane-bound complex binding site; other site 670487004100 hinge residues; other site 670487004101 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 670487004102 TRAM domain; Region: TRAM; cl01282 670487004103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 670487004104 S-adenosylmethionine binding site [chemical binding]; other site 670487004105 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 670487004106 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 670487004107 putative active site [active] 670487004108 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 670487004109 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 670487004110 substrate binding site [chemical binding]; other site 670487004111 glutamase interaction surface [polypeptide binding]; other site 670487004112 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 670487004113 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 670487004114 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 670487004115 metal binding site [ion binding]; metal-binding site 670487004116 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 670487004117 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 670487004118 putative active site [active] 670487004119 4-alpha-glucanotransferase; Provisional; Region: PRK14508 670487004120 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 670487004121 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 670487004122 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 670487004123 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 670487004124 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 670487004125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487004126 FeS/SAM binding site; other site 670487004127 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 670487004128 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 670487004129 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 670487004130 protein binding site [polypeptide binding]; other site 670487004131 butyrate kinase; Provisional; Region: PRK03011 670487004132 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 670487004133 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487004134 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 670487004135 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 670487004136 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 670487004137 Moco binding site; other site 670487004138 metal coordination site [ion binding]; other site 670487004139 dimerization interface [polypeptide binding]; other site 670487004140 Cytochrome c; Region: Cytochrom_C; pfam00034 670487004141 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487004142 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 670487004143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487004144 active site 670487004145 aspartate kinase; Reviewed; Region: PRK06635 670487004146 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 670487004147 putative catalytic residues [active] 670487004148 putative nucleotide binding site [chemical binding]; other site 670487004149 putative aspartate binding site [chemical binding]; other site 670487004150 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 670487004151 putative allosteric regulatory site; other site 670487004152 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 670487004153 putative allosteric regulatory residue; other site 670487004154 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 670487004155 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 670487004156 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 670487004157 threonine synthase; Reviewed; Region: PRK06721 670487004158 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 670487004159 homodimer interface [polypeptide binding]; other site 670487004160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487004161 catalytic residue [active] 670487004162 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 670487004163 Active site serine [active] 670487004164 2-phosphoglycerate kinase; Provisional; Region: PRK12337 670487004165 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 670487004166 recombination factor protein RarA; Reviewed; Region: PRK13342 670487004167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487004168 Walker A motif; other site 670487004169 ATP binding site [chemical binding]; other site 670487004170 Walker B motif; other site 670487004171 arginine finger; other site 670487004172 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 670487004173 PaaX-like protein; Region: PaaX; pfam07848 670487004174 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 670487004175 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 670487004176 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 670487004177 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 670487004178 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 670487004179 active site 670487004180 dimer interface [polypeptide binding]; other site 670487004181 motif 1; other site 670487004182 motif 2; other site 670487004183 motif 3; other site 670487004184 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 670487004185 anticodon binding site; other site 670487004186 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 670487004187 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 670487004188 HSP70 interaction site [polypeptide binding]; other site 670487004189 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 670487004190 substrate binding site [polypeptide binding]; other site 670487004191 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 670487004192 Zn binding sites [ion binding]; other site 670487004193 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 670487004194 dimer interface [polypeptide binding]; other site 670487004195 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 670487004196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 670487004197 ATP-grasp domain; Region: ATP-grasp_4; cl17255 670487004198 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 670487004199 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 670487004200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 670487004201 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 670487004202 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 670487004203 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 670487004204 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829 670487004205 RimM N-terminal domain; Region: RimM; pfam01782 670487004206 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 670487004207 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 670487004208 signal recognition particle protein; Provisional; Region: PRK10867 670487004209 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 670487004210 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 670487004211 P loop; other site 670487004212 GTP binding site [chemical binding]; other site 670487004213 Signal peptide binding domain; Region: SRP_SPB; pfam02978 670487004214 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 670487004215 MgtE intracellular N domain; Region: MgtE_N; pfam03448 670487004216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 670487004217 Divalent cation transporter; Region: MgtE; cl00786 670487004218 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 670487004219 metal binding sites [ion binding]; metal-binding site 670487004220 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 670487004221 active site 670487004222 catalytic residues [active] 670487004223 metal binding site [ion binding]; metal-binding site 670487004224 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 670487004225 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 670487004226 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 670487004227 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 670487004228 HIGH motif; other site 670487004229 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 670487004230 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 670487004231 active site 670487004232 KMSKS motif; other site 670487004233 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 670487004234 tRNA binding surface [nucleotide binding]; other site 670487004235 anticodon binding site; other site 670487004236 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 670487004237 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 670487004238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487004239 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 670487004240 TM-ABC transporter signature motif; other site 670487004241 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 670487004242 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 670487004243 Walker A/P-loop; other site 670487004244 ATP binding site [chemical binding]; other site 670487004245 Q-loop/lid; other site 670487004246 ABC transporter signature motif; other site 670487004247 Walker B; other site 670487004248 D-loop; other site 670487004249 H-loop/switch region; other site 670487004250 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 670487004251 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 670487004252 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 670487004253 ligand binding site [chemical binding]; other site 670487004254 dimerization interface [polypeptide binding]; other site 670487004255 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 670487004256 DHH family; Region: DHH; pfam01368 670487004257 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 670487004258 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 670487004259 Protein export membrane protein; Region: SecD_SecF; pfam02355 670487004260 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 670487004261 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 670487004262 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 670487004263 G1 box; other site 670487004264 putative GEF interaction site [polypeptide binding]; other site 670487004265 GTP/Mg2+ binding site [chemical binding]; other site 670487004266 Switch I region; other site 670487004267 G2 box; other site 670487004268 G3 box; other site 670487004269 Switch II region; other site 670487004270 G4 box; other site 670487004271 G5 box; other site 670487004272 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 670487004273 Translation-initiation factor 2; Region: IF-2; pfam11987 670487004274 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 670487004275 transcription termination factor NusA; Region: NusA; TIGR01953 670487004276 NusA N-terminal domain; Region: NusA_N; pfam08529 670487004277 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 670487004278 RNA binding site [nucleotide binding]; other site 670487004279 homodimer interface [polypeptide binding]; other site 670487004280 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 670487004281 G-X-X-G motif; other site 670487004282 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 670487004283 G-X-X-G motif; other site 670487004284 Sm and related proteins; Region: Sm_like; cl00259 670487004285 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 670487004286 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 670487004287 putative oligomer interface [polypeptide binding]; other site 670487004288 putative RNA binding site [nucleotide binding]; other site 670487004289 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 670487004290 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 670487004291 DNA binding site [nucleotide binding] 670487004292 catalytic residue [active] 670487004293 H2TH interface [polypeptide binding]; other site 670487004294 putative catalytic residues [active] 670487004295 turnover-facilitating residue; other site 670487004296 intercalation triad [nucleotide binding]; other site 670487004297 8OG recognition residue [nucleotide binding]; other site 670487004298 putative reading head residues; other site 670487004299 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 670487004300 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 670487004301 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 670487004302 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 670487004303 catalytic residues [active] 670487004304 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 670487004305 dimerization interface [polypeptide binding]; other site 670487004306 putative DNA binding site [nucleotide binding]; other site 670487004307 putative Zn2+ binding site [ion binding]; other site 670487004308 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 670487004309 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 670487004310 Walker A/P-loop; other site 670487004311 ATP binding site [chemical binding]; other site 670487004312 Q-loop/lid; other site 670487004313 ABC transporter signature motif; other site 670487004314 Walker B; other site 670487004315 D-loop; other site 670487004316 H-loop/switch region; other site 670487004317 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 670487004318 agmatinase; Region: agmatinase; TIGR01230 670487004319 Arginase family; Region: Arginase; cd09989 670487004320 active site 670487004321 Mn binding site [ion binding]; other site 670487004322 oligomer interface [polypeptide binding]; other site 670487004323 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 670487004324 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 670487004325 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 670487004326 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 670487004327 dimer interface [polypeptide binding]; other site 670487004328 active site 670487004329 CoA binding pocket [chemical binding]; other site 670487004330 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 670487004331 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 670487004332 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 670487004333 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 670487004334 NAD(P) binding site [chemical binding]; other site 670487004335 homotetramer interface [polypeptide binding]; other site 670487004336 homodimer interface [polypeptide binding]; other site 670487004337 active site 670487004338 acyl carrier protein; Provisional; Region: acpP; PRK00982 670487004339 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 670487004340 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 670487004341 dimer interface [polypeptide binding]; other site 670487004342 active site 670487004343 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 670487004344 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 670487004345 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 670487004346 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 670487004347 recombination protein RecR; Reviewed; Region: recR; PRK00076 670487004348 RecR protein; Region: RecR; pfam02132 670487004349 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 670487004350 putative active site [active] 670487004351 putative metal-binding site [ion binding]; other site 670487004352 tetramer interface [polypeptide binding]; other site 670487004353 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 670487004354 dimer interface [polypeptide binding]; other site 670487004355 active site 670487004356 Schiff base residues; other site 670487004357 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 670487004358 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 670487004359 active site 670487004360 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 670487004361 GIY-YIG motif/motif A; other site 670487004362 putative active site [active] 670487004363 putative metal binding site [ion binding]; other site 670487004364 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 670487004365 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 670487004366 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487004367 Zn2+ binding site [ion binding]; other site 670487004368 Mg2+ binding site [ion binding]; other site 670487004369 tartrate dehydrogenase; Region: TTC; TIGR02089 670487004370 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 670487004371 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 670487004372 Cell division protein FtsA; Region: FtsA; pfam14450 670487004373 Flagellar protein FliT; Region: FliT; pfam05400 670487004374 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 670487004375 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 670487004376 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 670487004377 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 670487004378 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 670487004379 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 670487004380 Tetramer interface [polypeptide binding]; other site 670487004381 active site 670487004382 FMN-binding site [chemical binding]; other site 670487004383 shikimate kinase; Provisional; Region: PRK13948 670487004384 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 670487004385 ADP binding site [chemical binding]; other site 670487004386 magnesium binding site [ion binding]; other site 670487004387 putative shikimate binding site; other site 670487004388 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 670487004389 active site 670487004390 dimer interface [polypeptide binding]; other site 670487004391 metal binding site [ion binding]; metal-binding site 670487004392 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 670487004393 Dehydroquinase class II; Region: DHquinase_II; pfam01220 670487004394 active site 670487004395 trimer interface [polypeptide binding]; other site 670487004396 dimer interface [polypeptide binding]; other site 670487004397 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 670487004398 Cysteine-rich domain; Region: CCG; pfam02754 670487004399 Cysteine-rich domain; Region: CCG; pfam02754 670487004400 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 670487004401 active site residue [active] 670487004402 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 670487004403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487004404 Walker A/P-loop; other site 670487004405 ATP binding site [chemical binding]; other site 670487004406 Q-loop/lid; other site 670487004407 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 670487004408 ABC transporter signature motif; other site 670487004409 Walker B; other site 670487004410 D-loop; other site 670487004411 H-loop/switch region; other site 670487004412 LrgA family; Region: LrgA; cl00608 670487004413 LrgB-like family; Region: LrgB; cl00596 670487004414 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 670487004415 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 670487004416 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 670487004417 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 670487004418 gamma-glutamyl kinase; Provisional; Region: PRK05429 670487004419 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 670487004420 nucleotide binding site [chemical binding]; other site 670487004421 homotetrameric interface [polypeptide binding]; other site 670487004422 putative phosphate binding site [ion binding]; other site 670487004423 putative allosteric binding site; other site 670487004424 PUA domain; Region: PUA; pfam01472 670487004425 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 670487004426 putative catalytic cysteine [active] 670487004427 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 670487004428 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 670487004429 nucleotide binding site [chemical binding]; other site 670487004430 Type III pantothenate kinase; Region: Pan_kinase; cl17198 670487004431 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487004432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487004433 metal binding site [ion binding]; metal-binding site 670487004434 active site 670487004435 I-site; other site 670487004436 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 670487004437 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 670487004438 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 670487004439 catalytic residue [active] 670487004440 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 670487004441 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 670487004442 Walker A/P-loop; other site 670487004443 ATP binding site [chemical binding]; other site 670487004444 Q-loop/lid; other site 670487004445 ABC transporter signature motif; other site 670487004446 Walker B; other site 670487004447 D-loop; other site 670487004448 H-loop/switch region; other site 670487004449 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 670487004450 FeS assembly protein SufB; Region: sufB; TIGR01980 670487004451 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 670487004452 FeS assembly protein SufD; Region: sufD; TIGR01981 670487004453 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 670487004454 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 670487004455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 670487004456 catalytic residue [active] 670487004457 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 670487004458 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 670487004459 trimerization site [polypeptide binding]; other site 670487004460 active site 670487004461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 670487004462 TAP-like protein; Region: Abhydrolase_4; pfam08386 670487004463 GAF domain; Region: GAF; cl17456 670487004464 GAF domain; Region: GAF_2; pfam13185 670487004465 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 670487004466 DNA binding site [nucleotide binding] 670487004467 Bacterial transcriptional activator domain; Region: BTAD; smart01043 670487004468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487004469 TPR motif; other site 670487004470 binding surface 670487004471 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487004472 Cytochrome c; Region: Cytochrom_C; pfam00034 670487004473 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 670487004474 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 670487004475 [4Fe-4S] binding site [ion binding]; other site 670487004476 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487004477 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487004478 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 670487004479 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 670487004480 molybdopterin cofactor binding site; other site 670487004481 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 670487004482 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 670487004483 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 670487004484 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 670487004485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487004486 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 670487004487 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 670487004488 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 670487004489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487004490 active site 670487004491 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 670487004492 active site 670487004493 dimer interface [polypeptide binding]; other site 670487004494 NosL; Region: NosL; cl01769 670487004495 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 670487004496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487004497 Walker A/P-loop; other site 670487004498 ATP binding site [chemical binding]; other site 670487004499 Q-loop/lid; other site 670487004500 ABC transporter signature motif; other site 670487004501 Walker B; other site 670487004502 D-loop; other site 670487004503 H-loop/switch region; other site 670487004504 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 670487004505 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 670487004506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487004507 active site 670487004508 phosphorylation site [posttranslational modification] 670487004509 intermolecular recognition site; other site 670487004510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 670487004511 DNA binding residues [nucleotide binding] 670487004512 dimerization interface [polypeptide binding]; other site 670487004513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 670487004514 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 670487004515 Mg2+ binding site [ion binding]; other site 670487004516 G-X-G motif; other site 670487004517 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 670487004518 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 670487004519 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 670487004520 Peptidase family M23; Region: Peptidase_M23; pfam01551 670487004521 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 670487004522 30S subunit binding site; other site 670487004523 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 670487004524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487004525 Walker A/P-loop; other site 670487004526 ATP binding site [chemical binding]; other site 670487004527 Q-loop/lid; other site 670487004528 ABC transporter signature motif; other site 670487004529 Walker B; other site 670487004530 D-loop; other site 670487004531 H-loop/switch region; other site 670487004532 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 670487004533 C-terminal peptidase (prc); Region: prc; TIGR00225 670487004534 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 670487004535 protein binding site [polypeptide binding]; other site 670487004536 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 670487004537 Catalytic dyad [active] 670487004538 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 670487004539 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 670487004540 Walker A/P-loop; other site 670487004541 ATP binding site [chemical binding]; other site 670487004542 Q-loop/lid; other site 670487004543 ABC transporter signature motif; other site 670487004544 Walker B; other site 670487004545 D-loop; other site 670487004546 H-loop/switch region; other site 670487004547 Protein of unknown function (DUF3197); Region: DUF3197; pfam11432 670487004548 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 670487004549 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 670487004550 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 670487004551 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 670487004552 substrate binding pocket [chemical binding]; other site 670487004553 dimer interface [polypeptide binding]; other site 670487004554 inhibitor binding site; inhibition site 670487004555 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 670487004556 B12 binding site [chemical binding]; other site 670487004557 cobalt ligand [ion binding]; other site 670487004558 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 670487004559 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 670487004560 GIY-YIG motif/motif A; other site 670487004561 putative active site [active] 670487004562 putative metal binding site [ion binding]; other site 670487004563 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 670487004564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487004565 FeS/SAM binding site; other site 670487004566 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 670487004567 PIN domain; Region: PIN_3; cl17397 670487004568 DNA polymerase III, delta subunit; Region: holA; TIGR01128 670487004569 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 670487004570 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 670487004571 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 670487004572 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 670487004573 active site 670487004574 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 670487004575 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 670487004576 V-type ATP synthase subunit B; Provisional; Region: PRK04196 670487004577 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 670487004578 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 670487004579 Walker A motif homologous position; other site 670487004580 Walker B motif; other site 670487004581 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 670487004582 V-type ATP synthase subunit A; Provisional; Region: PRK04192 670487004583 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 670487004584 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 670487004585 Walker A motif/ATP binding site; other site 670487004586 Walker B motif; other site 670487004587 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 670487004588 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 670487004589 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 670487004590 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 670487004591 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 670487004592 ATP synthase subunit C; Region: ATP-synt_C; cl00466 670487004593 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 670487004594 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 670487004595 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 670487004596 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 670487004597 putative RNA binding site [nucleotide binding]; other site 670487004598 Methyltransferase domain; Region: Methyltransf_26; pfam13659 670487004599 Protein of unknown function (DUF3248); Region: DUF3248; pfam11609 670487004600 Protein of unknown function (DUF3809); Region: DUF3809; pfam12723 670487004601 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 670487004602 metal-dependent hydrolase; Provisional; Region: PRK00685 670487004603 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 670487004604 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 670487004605 active site 670487004606 ATP binding site [chemical binding]; other site 670487004607 substrate binding site [chemical binding]; other site 670487004608 activation loop (A-loop); other site 670487004609 acetyl-CoA synthetase; Provisional; Region: PRK00174 670487004610 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 670487004611 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 670487004612 acyl-activating enzyme (AAE) consensus motif; other site 670487004613 putative AMP binding site [chemical binding]; other site 670487004614 putative active site [active] 670487004615 putative CoA binding site [chemical binding]; other site 670487004616 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 670487004617 GIY-YIG motif/motif A; other site 670487004618 putative active site [active] 670487004619 putative metal binding site [ion binding]; other site 670487004620 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 670487004621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 670487004622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487004623 homodimer interface [polypeptide binding]; other site 670487004624 catalytic residue [active] 670487004625 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 670487004626 active site 670487004627 putative catalytic site [active] 670487004628 DNA binding site [nucleotide binding] 670487004629 putative phosphate binding site [ion binding]; other site 670487004630 metal binding site A [ion binding]; metal-binding site 670487004631 AP binding site [nucleotide binding]; other site 670487004632 metal binding site B [ion binding]; metal-binding site 670487004633 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 670487004634 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 670487004635 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 670487004636 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 670487004637 glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703 670487004638 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 670487004639 active site 670487004640 HIGH motif; other site 670487004641 nucleotide binding site [chemical binding]; other site 670487004642 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 670487004643 active site 670487004644 KMSKS motif; other site 670487004645 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 670487004646 GatB domain; Region: GatB_Yqey; smart00845 670487004647 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 670487004648 Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209 670487004649 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 670487004650 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 670487004651 dimer interface [polypeptide binding]; other site 670487004652 effector binding site; other site 670487004653 active site 670487004654 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 670487004655 TSCPD domain; Region: TSCPD; pfam12637 670487004656 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 670487004657 active site 670487004658 homodimer interface [polypeptide binding]; other site 670487004659 catalytic site [active] 670487004660 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 670487004661 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 670487004662 catalytic site [active] 670487004663 G-X2-G-X-G-K; other site 670487004664 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 670487004665 Flavoprotein; Region: Flavoprotein; pfam02441 670487004666 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 670487004667 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 670487004668 Arginine repressor [Transcription]; Region: ArgR; COG1438 670487004669 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 670487004670 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 670487004671 MarC family integral membrane protein; Region: MarC; cl00919 670487004672 homoserine kinase; Provisional; Region: PRK01212 670487004673 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 670487004674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 670487004675 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 670487004676 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 670487004677 DNA binding site [nucleotide binding] 670487004678 active site 670487004679 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 670487004680 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 670487004681 active site 670487004682 Zn binding site [ion binding]; other site 670487004683 FOG: CBS domain [General function prediction only]; Region: COG0517 670487004684 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 670487004685 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 670487004686 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 670487004687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 670487004688 Coenzyme A binding pocket [chemical binding]; other site 670487004689 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 670487004690 MoaE interaction surface [polypeptide binding]; other site 670487004691 MoeB interaction surface [polypeptide binding]; other site 670487004692 thiocarboxylated glycine; other site 670487004693 Domain of unknown function (DUF1952); Region: DUF1952; pfam09189 670487004694 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 670487004695 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 670487004696 dimer interface [polypeptide binding]; other site 670487004697 active site 670487004698 glycine-pyridoxal phosphate binding site [chemical binding]; other site 670487004699 folate binding site [chemical binding]; other site 670487004700 GTP-binding protein Der; Reviewed; Region: PRK00093 670487004701 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 670487004702 G1 box; other site 670487004703 GTP/Mg2+ binding site [chemical binding]; other site 670487004704 Switch I region; other site 670487004705 G2 box; other site 670487004706 Switch II region; other site 670487004707 G3 box; other site 670487004708 G4 box; other site 670487004709 G5 box; other site 670487004710 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 670487004711 G1 box; other site 670487004712 GTP/Mg2+ binding site [chemical binding]; other site 670487004713 Switch I region; other site 670487004714 G2 box; other site 670487004715 G3 box; other site 670487004716 Switch II region; other site 670487004717 G4 box; other site 670487004718 G5 box; other site 670487004719 NAD-dependent deacetylase; Provisional; Region: PRK05333 670487004720 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 670487004721 NAD+ binding site [chemical binding]; other site 670487004722 substrate binding site [chemical binding]; other site 670487004723 Zn binding site [ion binding]; other site 670487004724 Ion channel; Region: Ion_trans_2; pfam07885 670487004725 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 670487004726 TrkA-N domain; Region: TrkA_N; pfam02254 670487004727 TrkA-C domain; Region: TrkA_C; pfam02080 670487004728 Uncharacterized conserved protein [Function unknown]; Region: COG0062 670487004729 putative carbohydrate kinase; Provisional; Region: PRK10565 670487004730 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 670487004731 putative substrate binding site [chemical binding]; other site 670487004732 putative ATP binding site [chemical binding]; other site 670487004733 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 670487004734 putative Iron-sulfur protein interface [polypeptide binding]; other site 670487004735 putative proximal heme binding site [chemical binding]; other site 670487004736 putative SdhD-like interface [polypeptide binding]; other site 670487004737 putative distal heme binding site [chemical binding]; other site 670487004738 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 670487004739 putative Iron-sulfur protein interface [polypeptide binding]; other site 670487004740 putative proximal heme binding site [chemical binding]; other site 670487004741 putative SdhC-like subunit interface [polypeptide binding]; other site 670487004742 putative distal heme binding site [chemical binding]; other site 670487004743 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 670487004744 L-aspartate oxidase; Provisional; Region: PRK06175 670487004745 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 670487004746 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 670487004747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 670487004748 catalytic loop [active] 670487004749 iron binding site [ion binding]; other site 670487004750 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 670487004751 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 670487004752 intracellular protease, PfpI family; Region: PfpI; TIGR01382 670487004753 conserved cys residue [active] 670487004754 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 670487004755 G1 box; other site 670487004756 GTP/Mg2+ binding site [chemical binding]; other site 670487004757 G2 box; other site 670487004758 Switch I region; other site 670487004759 G3 box; other site 670487004760 Switch II region; other site 670487004761 G4 box; other site 670487004762 G5 box; other site 670487004763 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 670487004764 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 670487004765 active site 670487004766 DNA binding site [nucleotide binding] 670487004767 Int/Topo IB signature motif; other site 670487004768 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 670487004769 heterotetramer interface [polypeptide binding]; other site 670487004770 active site pocket [active] 670487004771 cleavage site 670487004772 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 670487004773 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 670487004774 ornithine carbamoyltransferase; Provisional; Region: PRK00779 670487004775 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 670487004776 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 670487004777 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 670487004778 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 670487004779 putative DNA binding site [nucleotide binding]; other site 670487004780 putative Zn2+ binding site [ion binding]; other site 670487004781 Transcriptional regulator PadR-like family; Region: PadR; cl17335 670487004782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487004783 putative substrate translocation pore; other site 670487004784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487004785 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 670487004786 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 670487004787 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 670487004788 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 670487004789 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 670487004790 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 670487004791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487004792 Walker A/P-loop; other site 670487004793 ATP binding site [chemical binding]; other site 670487004794 Q-loop/lid; other site 670487004795 ABC transporter signature motif; other site 670487004796 Walker B; other site 670487004797 D-loop; other site 670487004798 H-loop/switch region; other site 670487004799 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 670487004800 alanine racemase; Reviewed; Region: alr; PRK00053 670487004801 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 670487004802 active site 670487004803 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 670487004804 dimer interface [polypeptide binding]; other site 670487004805 substrate binding site [chemical binding]; other site 670487004806 catalytic residues [active] 670487004807 Uncharacterized conserved protein [Function unknown]; Region: COG3603 670487004808 Family description; Region: ACT_7; pfam13840 670487004809 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 670487004810 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 670487004811 putative NAD(P) binding site [chemical binding]; other site 670487004812 active site 670487004813 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 670487004814 Moco binding site; other site 670487004815 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 670487004816 metal coordination site [ion binding]; other site 670487004817 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 670487004818 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 670487004819 CrcB-like protein; Region: CRCB; cl09114 670487004820 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 670487004821 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 670487004822 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 670487004823 Protein of unknown function (DUF533); Region: DUF533; pfam04391 670487004824 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 670487004825 putative metal binding site [ion binding]; other site 670487004826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487004827 binding surface 670487004828 TPR motif; other site 670487004829 TPR repeat; Region: TPR_11; pfam13414 670487004830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487004831 binding surface 670487004832 TPR motif; other site 670487004833 TPR repeat; Region: TPR_11; pfam13414 670487004834 TPR repeat; Region: TPR_11; pfam13414 670487004835 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 670487004836 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 670487004837 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 670487004838 dimer interface [polypeptide binding]; other site 670487004839 motif 1; other site 670487004840 active site 670487004841 motif 2; other site 670487004842 motif 3; other site 670487004843 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 670487004844 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 670487004845 putative tRNA-binding site [nucleotide binding]; other site 670487004846 B3/4 domain; Region: B3_4; pfam03483 670487004847 tRNA synthetase B5 domain; Region: B5; smart00874 670487004848 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 670487004849 dimer interface [polypeptide binding]; other site 670487004850 motif 1; other site 670487004851 motif 3; other site 670487004852 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 670487004853 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 670487004854 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 670487004855 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 670487004856 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 670487004857 metal ion-dependent adhesion site (MIDAS); other site 670487004858 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 670487004859 active site 670487004860 catalytic residues [active] 670487004861 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 670487004862 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 670487004863 active site 670487004864 catalytic residues [active] 670487004865 GTP-binding protein LepA; Provisional; Region: PRK05433 670487004866 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 670487004867 G1 box; other site 670487004868 putative GEF interaction site [polypeptide binding]; other site 670487004869 GTP/Mg2+ binding site [chemical binding]; other site 670487004870 Switch I region; other site 670487004871 G2 box; other site 670487004872 G3 box; other site 670487004873 Switch II region; other site 670487004874 G4 box; other site 670487004875 G5 box; other site 670487004876 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 670487004877 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 670487004878 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 670487004879 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 670487004880 tyrosine phenol-lyase; Provisional; Region: PRK13237 670487004881 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 670487004882 substrate binding site [chemical binding]; other site 670487004883 tetramer interface [polypeptide binding]; other site 670487004884 catalytic residue [active] 670487004885 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 670487004886 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 670487004887 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 670487004888 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 670487004889 active site 670487004890 HIGH motif; other site 670487004891 KMSK motif region; other site 670487004892 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 670487004893 tRNA binding surface [nucleotide binding]; other site 670487004894 anticodon binding site; other site 670487004895 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 670487004896 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 670487004897 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 670487004898 protein binding site [polypeptide binding]; other site 670487004899 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 670487004900 Substrate-binding site [chemical binding]; other site 670487004901 Substrate specificity [chemical binding]; other site 670487004902 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 670487004903 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 670487004904 Substrate-binding site [chemical binding]; other site 670487004905 Substrate specificity [chemical binding]; other site 670487004906 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 670487004907 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 670487004908 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 670487004909 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 670487004910 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 670487004911 nucleotide binding site/active site [active] 670487004912 HIT family signature motif; other site 670487004913 catalytic residue [active] 670487004914 Uncharacterized conserved protein [Function unknown]; Region: COG0327 670487004915 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 670487004916 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 670487004917 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 670487004918 TMP-binding site; other site 670487004919 ATP-binding site [chemical binding]; other site 670487004920 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 670487004921 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 670487004922 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 670487004923 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 670487004924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487004925 motif II; other site 670487004926 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 670487004927 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 670487004928 Uncharacterized conserved protein [Function unknown]; Region: COG3270 670487004929 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 670487004930 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 670487004931 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 670487004932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 670487004933 Coenzyme A binding pocket [chemical binding]; other site 670487004934 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 670487004935 Cupin domain; Region: Cupin_2; pfam07883 670487004936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 670487004937 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 670487004938 putative NAD(P) binding site [chemical binding]; other site 670487004939 putative active site [active] 670487004940 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 670487004941 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 670487004942 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 670487004943 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 670487004944 peroxiredoxin; Provisional; Region: PRK13189 670487004945 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 670487004946 dimer interface [polypeptide binding]; other site 670487004947 decamer (pentamer of dimers) interface [polypeptide binding]; other site 670487004948 catalytic triad [active] 670487004949 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 670487004950 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 670487004951 homodimer interface [polypeptide binding]; other site 670487004952 substrate-cofactor binding pocket; other site 670487004953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487004954 catalytic residue [active] 670487004955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487004956 S-adenosylmethionine binding site [chemical binding]; other site 670487004957 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 670487004958 Haemolysin-III related; Region: HlyIII; cl03831 670487004959 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487004960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487004961 active site 670487004962 phosphorylation site [posttranslational modification] 670487004963 intermolecular recognition site; other site 670487004964 dimerization interface [polypeptide binding]; other site 670487004965 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487004966 DNA binding site [nucleotide binding] 670487004967 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 670487004968 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 670487004969 dimerization interface [polypeptide binding]; other site 670487004970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487004971 dimer interface [polypeptide binding]; other site 670487004972 phosphorylation site [posttranslational modification] 670487004973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487004974 ATP binding site [chemical binding]; other site 670487004975 Mg2+ binding site [ion binding]; other site 670487004976 G-X-G motif; other site 670487004977 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 670487004978 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 670487004979 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 670487004980 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 670487004981 tRNA; other site 670487004982 putative tRNA binding site [nucleotide binding]; other site 670487004983 putative NADP binding site [chemical binding]; other site 670487004984 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 670487004985 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 670487004986 active site 670487004987 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 670487004988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487004989 HemN C-terminal domain; Region: HemN_C; pfam06969 670487004990 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 670487004991 Mechanosensitive ion channel; Region: MS_channel; pfam00924 670487004992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487004993 S-adenosylmethionine binding site [chemical binding]; other site 670487004994 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 670487004995 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 670487004996 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 670487004997 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 670487004998 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 670487004999 putative NAD(P) binding site [chemical binding]; other site 670487005000 structural Zn binding site [ion binding]; other site 670487005001 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 670487005002 Uncharacterized conserved protein [Function unknown]; Region: COG1432 670487005003 LabA_like proteins; Region: LabA_like/DUF88; cl10034 670487005004 putative metal binding site [ion binding]; other site 670487005005 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 670487005006 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 670487005007 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 670487005008 alphaNTD - beta interaction site [polypeptide binding]; other site 670487005009 alphaNTD homodimer interface [polypeptide binding]; other site 670487005010 alphaNTD - beta' interaction site [polypeptide binding]; other site 670487005011 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 670487005012 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 670487005013 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 670487005014 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 670487005015 RNA binding surface [nucleotide binding]; other site 670487005016 30S ribosomal protein S11; Validated; Region: PRK05309 670487005017 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 670487005018 30S ribosomal protein S13; Region: bact_S13; TIGR03631 670487005019 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 670487005020 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 670487005021 rRNA binding site [nucleotide binding]; other site 670487005022 predicted 30S ribosome binding site; other site 670487005023 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 670487005024 active site 670487005025 adenylate kinase; Provisional; Region: PRK14527 670487005026 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 670487005027 AMP-binding site [chemical binding]; other site 670487005028 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 670487005029 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 670487005030 SecY translocase; Region: SecY; pfam00344 670487005031 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 670487005032 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 670487005033 23S rRNA binding site [nucleotide binding]; other site 670487005034 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 670487005035 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 670487005036 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 670487005037 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 670487005038 5S rRNA interface [nucleotide binding]; other site 670487005039 L5 interface [polypeptide binding]; other site 670487005040 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 670487005041 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 670487005042 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 670487005043 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 670487005044 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 670487005045 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 670487005046 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 670487005047 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 670487005048 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 670487005049 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 670487005050 RNA binding site [nucleotide binding]; other site 670487005051 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 670487005052 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 670487005053 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 670487005054 23S rRNA interface [nucleotide binding]; other site 670487005055 putative translocon interaction site; other site 670487005056 signal recognition particle (SRP54) interaction site; other site 670487005057 L23 interface [polypeptide binding]; other site 670487005058 trigger factor interaction site; other site 670487005059 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 670487005060 23S rRNA interface [nucleotide binding]; other site 670487005061 5S rRNA interface [nucleotide binding]; other site 670487005062 putative antibiotic binding site [chemical binding]; other site 670487005063 L25 interface [polypeptide binding]; other site 670487005064 L27 interface [polypeptide binding]; other site 670487005065 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 670487005066 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 670487005067 G-X-X-G motif; other site 670487005068 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 670487005069 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 670487005070 putative translocon binding site; other site 670487005071 protein-rRNA interface [nucleotide binding]; other site 670487005072 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 670487005073 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 670487005074 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 670487005075 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 670487005076 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 670487005077 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 670487005078 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 670487005079 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 670487005080 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 670487005081 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 670487005082 G1 box; other site 670487005083 GEF interaction site [polypeptide binding]; other site 670487005084 GTP/Mg2+ binding site [chemical binding]; other site 670487005085 Switch I region; other site 670487005086 G2 box; other site 670487005087 G3 box; other site 670487005088 Switch II region; other site 670487005089 G4 box; other site 670487005090 G5 box; other site 670487005091 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 670487005092 elongation factor G; Reviewed; Region: PRK00007 670487005093 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 670487005094 G1 box; other site 670487005095 putative GEF interaction site [polypeptide binding]; other site 670487005096 GTP/Mg2+ binding site [chemical binding]; other site 670487005097 Switch I region; other site 670487005098 G2 box; other site 670487005099 G3 box; other site 670487005100 Switch II region; other site 670487005101 G4 box; other site 670487005102 G5 box; other site 670487005103 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 670487005104 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 670487005105 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 670487005106 30S ribosomal protein S7; Validated; Region: PRK05302 670487005107 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 670487005108 S17 interaction site [polypeptide binding]; other site 670487005109 S8 interaction site; other site 670487005110 16S rRNA interaction site [nucleotide binding]; other site 670487005111 streptomycin interaction site [chemical binding]; other site 670487005112 23S rRNA interaction site [nucleotide binding]; other site 670487005113 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 670487005114 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 670487005115 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 670487005116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005117 putative PBP binding loops; other site 670487005118 ABC-ATPase subunit interface; other site 670487005119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005120 ABC-ATPase subunit interface; other site 670487005121 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 670487005122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487005123 Walker A/P-loop; other site 670487005124 ATP binding site [chemical binding]; other site 670487005125 Q-loop/lid; other site 670487005126 ABC transporter signature motif; other site 670487005127 Walker B; other site 670487005128 D-loop; other site 670487005129 H-loop/switch region; other site 670487005130 TOBE domain; Region: TOBE_2; pfam08402 670487005131 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 670487005132 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 670487005133 dimerization interface 3.5A [polypeptide binding]; other site 670487005134 active site 670487005135 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 670487005136 tetramer interface [polypeptide binding]; other site 670487005137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487005138 catalytic residue [active] 670487005139 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 670487005140 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 670487005141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 670487005142 catalytic residue [active] 670487005143 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 670487005144 lipoyl attachment site [posttranslational modification]; other site 670487005145 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 670487005146 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 670487005147 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 670487005148 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 670487005149 G1 box; other site 670487005150 GTP/Mg2+ binding site [chemical binding]; other site 670487005151 G2 box; other site 670487005152 Switch I region; other site 670487005153 G3 box; other site 670487005154 Switch II region; other site 670487005155 G4 box; other site 670487005156 G5 box; other site 670487005157 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 670487005158 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 670487005159 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 670487005160 Zn binding site [ion binding]; other site 670487005161 H+ Antiporter protein; Region: 2A0121; TIGR00900 670487005162 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 670487005163 Protein phosphatase 2C; Region: PP2C; pfam00481 670487005164 active site 670487005165 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 670487005166 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 670487005167 active site 670487005168 ATP binding site [chemical binding]; other site 670487005169 substrate binding site [chemical binding]; other site 670487005170 activation loop (A-loop); other site 670487005171 NHL repeat; Region: NHL; pfam01436 670487005172 SdiA-regulated; Region: SdiA-regulated; cd09971 670487005173 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 670487005174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487005175 Zn2+ binding site [ion binding]; other site 670487005176 Mg2+ binding site [ion binding]; other site 670487005177 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 670487005178 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 670487005179 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 670487005180 4Fe-4S binding domain; Region: Fer4; cl02805 670487005181 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 670487005182 Cysteine-rich domain; Region: CCG; pfam02754 670487005183 Cysteine-rich domain; Region: CCG; pfam02754 670487005184 Divergent PAP2 family; Region: DUF212; pfam02681 670487005185 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14173 670487005186 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 670487005187 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 670487005188 homodimer interface [polypeptide binding]; other site 670487005189 NADP binding site [chemical binding]; other site 670487005190 substrate binding site [chemical binding]; other site 670487005191 transcription antitermination factor NusB; Region: nusB; TIGR01951 670487005192 putative RNA binding site [nucleotide binding]; other site 670487005193 Asp23 family; Region: Asp23; cl00574 670487005194 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 670487005195 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 670487005196 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 670487005197 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 670487005198 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 670487005199 carboxyltransferase (CT) interaction site; other site 670487005200 biotinylation site [posttranslational modification]; other site 670487005201 elongation factor P; Validated; Region: PRK00529 670487005202 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 670487005203 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 670487005204 RNA binding site [nucleotide binding]; other site 670487005205 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 670487005206 RNA binding site [nucleotide binding]; other site 670487005207 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 670487005208 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 670487005209 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 670487005210 TPP-binding site [chemical binding]; other site 670487005211 dimer interface [polypeptide binding]; other site 670487005212 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 670487005213 PYR/PP interface [polypeptide binding]; other site 670487005214 dimer interface [polypeptide binding]; other site 670487005215 TPP binding site [chemical binding]; other site 670487005216 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 670487005217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487005218 binding surface 670487005219 TPR motif; other site 670487005220 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 670487005221 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 670487005222 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 670487005223 putative ligand binding site [chemical binding]; other site 670487005224 putative NAD binding site [chemical binding]; other site 670487005225 catalytic site [active] 670487005226 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 670487005227 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 670487005228 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 670487005229 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 670487005230 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 670487005231 NAD(P) binding site [chemical binding]; other site 670487005232 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 670487005233 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 670487005234 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 670487005235 NAD(P) binding site [chemical binding]; other site 670487005236 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 670487005237 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 670487005238 substrate binding pocket [chemical binding]; other site 670487005239 chain length determination region; other site 670487005240 substrate-Mg2+ binding site; other site 670487005241 catalytic residues [active] 670487005242 aspartate-rich region 1; other site 670487005243 active site lid residues [active] 670487005244 aspartate-rich region 2; other site 670487005245 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 670487005246 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 670487005247 CoA binding domain; Region: CoA_binding; smart00881 670487005248 Sporulation related domain; Region: SPOR; pfam05036 670487005249 Sporulation related domain; Region: SPOR; pfam05036 670487005250 Tetratricopeptide repeat; Region: TPR_16; pfam13432 670487005251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487005252 TPR motif; other site 670487005253 binding surface 670487005254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487005255 binding surface 670487005256 TPR motif; other site 670487005257 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 670487005258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487005259 binding surface 670487005260 TPR motif; other site 670487005261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487005262 TPR motif; other site 670487005263 TPR repeat; Region: TPR_11; pfam13414 670487005264 binding surface 670487005265 Protein of unknown function (DUF420); Region: DUF420; cl00989 670487005266 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 670487005267 dimer interface [polypeptide binding]; other site 670487005268 putative tRNA-binding site [nucleotide binding]; other site 670487005269 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 670487005270 CoA-transferase family III; Region: CoA_transf_3; pfam02515 670487005271 hypothetical protein; Provisional; Region: PRK08609 670487005272 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 670487005273 active site 670487005274 primer binding site [nucleotide binding]; other site 670487005275 NTP binding site [chemical binding]; other site 670487005276 metal binding triad [ion binding]; metal-binding site 670487005277 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 670487005278 active site 670487005279 Cytochrome c oxidase subunit IIa family; Region: CoxIIa; pfam08113 670487005280 Cytochrome C oxidase subunit II, transmembrane; Region: COX2-transmemb; pfam09125 670487005281 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 670487005282 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 670487005283 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 670487005284 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 670487005285 D-pathway; other site 670487005286 Low-spin heme binding site [chemical binding]; other site 670487005287 Putative water exit pathway; other site 670487005288 Binuclear center (active site) [active] 670487005289 K-pathway; other site 670487005290 Putative proton exit pathway; other site 670487005291 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 670487005292 16S/18S rRNA binding site [nucleotide binding]; other site 670487005293 S13e-L30e interaction site [polypeptide binding]; other site 670487005294 25S rRNA binding site [nucleotide binding]; other site 670487005295 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 670487005296 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 670487005297 RNase E interface [polypeptide binding]; other site 670487005298 trimer interface [polypeptide binding]; other site 670487005299 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 670487005300 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 670487005301 RNase E interface [polypeptide binding]; other site 670487005302 trimer interface [polypeptide binding]; other site 670487005303 active site 670487005304 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 670487005305 putative nucleic acid binding region [nucleotide binding]; other site 670487005306 G-X-X-G motif; other site 670487005307 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 670487005308 RNA binding site [nucleotide binding]; other site 670487005309 domain interface; other site 670487005310 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 670487005311 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 670487005312 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 670487005313 Membrane transport protein; Region: Mem_trans; cl09117 670487005314 RNA methyltransferase, RsmE family; Region: TIGR00046 670487005315 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 670487005316 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 670487005317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487005318 S-adenosylmethionine binding site [chemical binding]; other site 670487005319 hypothetical protein; Provisional; Region: PRK07906 670487005320 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 670487005321 putative metal binding site [ion binding]; other site 670487005322 6-phosphofructokinase; Provisional; Region: PRK03202 670487005323 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 670487005324 active site 670487005325 ADP/pyrophosphate binding site [chemical binding]; other site 670487005326 dimerization interface [polypeptide binding]; other site 670487005327 allosteric effector site; other site 670487005328 fructose-1,6-bisphosphate binding site; other site 670487005329 Predicted methyltransferases [General function prediction only]; Region: COG0313 670487005330 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 670487005331 putative SAM binding site [chemical binding]; other site 670487005332 putative homodimer interface [polypeptide binding]; other site 670487005333 EamA-like transporter family; Region: EamA; pfam00892 670487005334 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 670487005335 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 670487005336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 670487005337 Coenzyme A binding pocket [chemical binding]; other site 670487005338 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 670487005339 ROK family; Region: ROK; pfam00480 670487005340 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 670487005341 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 670487005342 peptidase; Reviewed; Region: PRK13004 670487005343 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 670487005344 metal binding site [ion binding]; metal-binding site 670487005345 dimer interface [polypeptide binding]; other site 670487005346 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 670487005347 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 670487005348 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 670487005349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 670487005350 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 670487005351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005352 dimer interface [polypeptide binding]; other site 670487005353 ABC-ATPase subunit interface; other site 670487005354 putative PBP binding loops; other site 670487005355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 670487005356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005357 dimer interface [polypeptide binding]; other site 670487005358 conserved gate region; other site 670487005359 putative PBP binding loops; other site 670487005360 ABC-ATPase subunit interface; other site 670487005361 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 670487005362 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 670487005363 peptide binding site [polypeptide binding]; other site 670487005364 dimer interface [polypeptide binding]; other site 670487005365 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 670487005366 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 670487005367 active site 670487005368 amino acid transporter; Region: 2A0306; TIGR00909 670487005369 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 670487005370 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 670487005371 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 670487005372 active site 670487005373 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 670487005374 EamA-like transporter family; Region: EamA; pfam00892 670487005375 O-Antigen ligase; Region: Wzy_C; pfam04932 670487005376 Tetratricopeptide repeat; Region: TPR_12; pfam13424 670487005377 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 670487005378 active site 670487005379 homopentamer interface [polypeptide binding]; other site 670487005380 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 670487005381 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 670487005382 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 670487005383 dimerization interface [polypeptide binding]; other site 670487005384 active site 670487005385 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 670487005386 Lumazine binding domain; Region: Lum_binding; pfam00677 670487005387 Lumazine binding domain; Region: Lum_binding; pfam00677 670487005388 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 670487005389 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 670487005390 catalytic motif [active] 670487005391 Zn binding site [ion binding]; other site 670487005392 RibD C-terminal domain; Region: RibD_C; cl17279 670487005393 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 670487005394 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 670487005395 substrate binding site [chemical binding]; other site 670487005396 tetramer interface [polypeptide binding]; other site 670487005397 catalytic residue [active] 670487005398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 670487005399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 670487005400 active site 670487005401 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 670487005402 Ligand binding site [chemical binding]; other site 670487005403 Electron transfer flavoprotein domain; Region: ETF; pfam01012 670487005404 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 670487005405 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 670487005406 Ligand Binding Site [chemical binding]; other site 670487005407 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 670487005408 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 670487005409 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 670487005410 putative active site [active] 670487005411 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 670487005412 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 670487005413 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 670487005414 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 670487005415 Fe-S cluster binding site [ion binding]; other site 670487005416 DNA binding site [nucleotide binding] 670487005417 active site 670487005418 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 670487005419 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 670487005420 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 670487005421 homodecamer interface [polypeptide binding]; other site 670487005422 GTP cyclohydrolase I; Provisional; Region: PLN03044 670487005423 active site 670487005424 putative catalytic site residues [active] 670487005425 zinc binding site [ion binding]; other site 670487005426 GTP-CH-I/GFRP interaction surface; other site 670487005427 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 670487005428 classical (c) SDRs; Region: SDR_c; cd05233 670487005429 NAD(P) binding site [chemical binding]; other site 670487005430 active site 670487005431 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 670487005432 nudix motif; other site 670487005433 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 670487005434 Domain of unknown function (DUF955); Region: DUF955; cl01076 670487005435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 670487005436 non-specific DNA binding site [nucleotide binding]; other site 670487005437 salt bridge; other site 670487005438 sequence-specific DNA binding site [nucleotide binding]; other site 670487005439 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 670487005440 putative active site pocket [active] 670487005441 dimerization interface [polypeptide binding]; other site 670487005442 putative catalytic residue [active] 670487005443 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 670487005444 NADPH bind site [chemical binding]; other site 670487005445 putative FMN binding site [chemical binding]; other site 670487005446 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 670487005447 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 670487005448 ligand binding site; other site 670487005449 oligomer interface; other site 670487005450 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 670487005451 dimer interface [polypeptide binding]; other site 670487005452 N-terminal domain interface [polypeptide binding]; other site 670487005453 sulfate 1 binding site; other site 670487005454 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 670487005455 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 670487005456 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 670487005457 oligomerisation interface [polypeptide binding]; other site 670487005458 mobile loop; other site 670487005459 roof hairpin; other site 670487005460 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 670487005461 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 670487005462 ring oligomerisation interface [polypeptide binding]; other site 670487005463 ATP/Mg binding site [chemical binding]; other site 670487005464 stacking interactions; other site 670487005465 hinge regions; other site 670487005466 Predicted transcriptional regulators [Transcription]; Region: COG1733 670487005467 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 670487005468 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 670487005469 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 670487005470 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 670487005471 tetramer interface [polypeptide binding]; other site 670487005472 TPP-binding site [chemical binding]; other site 670487005473 heterodimer interface [polypeptide binding]; other site 670487005474 phosphorylation loop region [posttranslational modification] 670487005475 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 670487005476 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 670487005477 alpha subunit interface [polypeptide binding]; other site 670487005478 TPP binding site [chemical binding]; other site 670487005479 heterodimer interface [polypeptide binding]; other site 670487005480 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 670487005481 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 670487005482 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 670487005483 E3 interaction surface; other site 670487005484 lipoyl attachment site [posttranslational modification]; other site 670487005485 e3 binding domain; Region: E3_binding; pfam02817 670487005486 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 670487005487 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 670487005488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 670487005489 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 670487005490 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 670487005491 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 670487005492 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 670487005493 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 670487005494 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 670487005495 dimer interface [polypeptide binding]; other site 670487005496 PYR/PP interface [polypeptide binding]; other site 670487005497 TPP binding site [chemical binding]; other site 670487005498 substrate binding site [chemical binding]; other site 670487005499 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177 670487005500 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 670487005501 TPP-binding site [chemical binding]; other site 670487005502 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 670487005503 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 670487005504 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 670487005505 hinge; other site 670487005506 active site 670487005507 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 670487005508 DHH family; Region: DHH; pfam01368 670487005509 DHHA1 domain; Region: DHHA1; pfam02272 670487005510 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 670487005511 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 670487005512 MOFRL family; Region: MOFRL; pfam05161 670487005513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 670487005514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 670487005515 DNA binding site [nucleotide binding] 670487005516 domain linker motif; other site 670487005517 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 670487005518 ligand binding site [chemical binding]; other site 670487005519 dimerization interface [polypeptide binding]; other site 670487005520 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 670487005521 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 670487005522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005523 dimer interface [polypeptide binding]; other site 670487005524 conserved gate region; other site 670487005525 putative PBP binding loops; other site 670487005526 ABC-ATPase subunit interface; other site 670487005527 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 670487005528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005529 dimer interface [polypeptide binding]; other site 670487005530 conserved gate region; other site 670487005531 putative PBP binding loops; other site 670487005532 ABC-ATPase subunit interface; other site 670487005533 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 670487005534 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 670487005535 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 670487005536 sucrose phosphorylase; Provisional; Region: PRK13840 670487005537 active site 670487005538 homodimer interface [polypeptide binding]; other site 670487005539 catalytic site [active] 670487005540 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 670487005541 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 670487005542 lipoyl synthase; Provisional; Region: PRK05481 670487005543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487005544 FeS/SAM binding site; other site 670487005545 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 670487005546 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 670487005547 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 670487005548 CMP-binding site; other site 670487005549 The sites determining sugar specificity; other site 670487005550 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 670487005551 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 670487005552 active site 670487005553 catalytic residues [active] 670487005554 metal binding site [ion binding]; metal-binding site 670487005555 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 670487005556 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 670487005557 substrate binding site [chemical binding]; other site 670487005558 ligand binding site [chemical binding]; other site 670487005559 homoaconitate hydratase small subunit; Provisional; Region: PRK14023 670487005560 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 670487005561 substrate binding site [chemical binding]; other site 670487005562 Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014 670487005563 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 670487005564 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 670487005565 ATP-grasp domain; Region: ATP-grasp_4; cl17255 670487005566 Protein of unknown function, DUF488; Region: DUF488; pfam04343 670487005567 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 670487005568 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 670487005569 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 670487005570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487005571 FeS/SAM binding site; other site 670487005572 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 670487005573 putative ligand binding pocket/active site [active] 670487005574 putative metal binding site [ion binding]; other site 670487005575 AMMECR1; Region: AMMECR1; cl00911 670487005576 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 670487005577 putative active site [active] 670487005578 putative NTP binding site [chemical binding]; other site 670487005579 putative nucleic acid binding site [nucleotide binding]; other site 670487005580 Phosphagen (guanidino) kinases mostly found in eukaryotes; Region: eukaryotic_phosphagen_kinases; cd07931 670487005581 phosphagen binding site; other site 670487005582 ADP binding site [chemical binding]; other site 670487005583 substrate specificity loop; other site 670487005584 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 670487005585 GIY-YIG motif/motif A; other site 670487005586 putative active site [active] 670487005587 putative metal binding site [ion binding]; other site 670487005588 acetylglutamate/acetylaminoadipate kinase; Provisional; Region: PRK14058 670487005589 nucleotide binding site [chemical binding]; other site 670487005590 substrate binding site [chemical binding]; other site 670487005591 acetylornithine aminotransferase; Provisional; Region: PRK02627 670487005592 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 670487005593 inhibitor-cofactor binding pocket; inhibition site 670487005594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487005595 catalytic residue [active] 670487005596 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 670487005597 acetyl-lysine deacetylase; Provisional; Region: PRK04443 670487005598 metal binding site [ion binding]; metal-binding site 670487005599 putative dimer interface [polypeptide binding]; other site 670487005600 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 670487005601 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 670487005602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487005603 Walker B; other site 670487005604 D-loop; other site 670487005605 H-loop/switch region; other site 670487005606 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487005607 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487005608 metal binding site [ion binding]; metal-binding site 670487005609 active site 670487005610 I-site; other site 670487005611 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 670487005612 glycerol kinase; Provisional; Region: glpK; PRK00047 670487005613 N- and C-terminal domain interface [polypeptide binding]; other site 670487005614 active site 670487005615 MgATP binding site [chemical binding]; other site 670487005616 catalytic site [active] 670487005617 metal binding site [ion binding]; metal-binding site 670487005618 glycerol binding site [chemical binding]; other site 670487005619 homotetramer interface [polypeptide binding]; other site 670487005620 homodimer interface [polypeptide binding]; other site 670487005621 FBP binding site [chemical binding]; other site 670487005622 protein IIAGlc interface [polypeptide binding]; other site 670487005623 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 670487005624 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 670487005625 active site 670487005626 metal binding site [ion binding]; metal-binding site 670487005627 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 670487005628 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 670487005629 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 670487005630 S-adenosylmethionine synthetase; Validated; Region: PRK05250 670487005631 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 670487005632 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 670487005633 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 670487005634 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487005635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487005636 metal binding site [ion binding]; metal-binding site 670487005637 active site 670487005638 I-site; other site 670487005639 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 670487005640 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 670487005641 substrate-cofactor binding pocket; other site 670487005642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487005643 catalytic residue [active] 670487005644 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 670487005645 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 670487005646 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 670487005647 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 670487005648 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 670487005649 ligand binding site [chemical binding]; other site 670487005650 homodimer interface [polypeptide binding]; other site 670487005651 NAD(P) binding site [chemical binding]; other site 670487005652 trimer interface B [polypeptide binding]; other site 670487005653 trimer interface A [polypeptide binding]; other site 670487005654 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 670487005655 dimer interface [polypeptide binding]; other site 670487005656 FMN binding site [chemical binding]; other site 670487005657 NADPH bind site [chemical binding]; other site 670487005658 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 670487005659 CoA-transferase family III; Region: CoA_transf_3; pfam02515 670487005660 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 670487005661 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 670487005662 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 670487005663 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 670487005664 DctM-like transporters; Region: DctM; pfam06808 670487005665 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 670487005666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 670487005667 active site 670487005668 YceG-like family; Region: YceG; pfam02618 670487005669 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 670487005670 dimerization interface [polypeptide binding]; other site 670487005671 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 670487005672 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 670487005673 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 670487005674 motif 1; other site 670487005675 active site 670487005676 motif 2; other site 670487005677 motif 3; other site 670487005678 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 670487005679 DHHA1 domain; Region: DHHA1; pfam02272 670487005680 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 670487005681 FtsX-like permease family; Region: FtsX; pfam02687 670487005682 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 670487005683 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 670487005684 Walker A/P-loop; other site 670487005685 ATP binding site [chemical binding]; other site 670487005686 Q-loop/lid; other site 670487005687 ABC transporter signature motif; other site 670487005688 Walker B; other site 670487005689 D-loop; other site 670487005690 H-loop/switch region; other site 670487005691 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 670487005692 GAF domain; Region: GAF; pfam01590 670487005693 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 670487005694 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 670487005695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 670487005696 metal binding site [ion binding]; metal-binding site 670487005697 active site 670487005698 I-site; other site 670487005699 polyphosphate kinase; Provisional; Region: PRK05443 670487005700 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 670487005701 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 670487005702 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 670487005703 putative active site [active] 670487005704 catalytic site [active] 670487005705 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 670487005706 putative active site [active] 670487005707 catalytic site [active] 670487005708 exopolyphosphatase; Region: exo_poly_only; TIGR03706 670487005709 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 670487005710 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 670487005711 catalytic core [active] 670487005712 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 670487005713 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 670487005714 Walker A/P-loop; other site 670487005715 ATP binding site [chemical binding]; other site 670487005716 Q-loop/lid; other site 670487005717 ABC transporter signature motif; other site 670487005718 Walker B; other site 670487005719 D-loop; other site 670487005720 H-loop/switch region; other site 670487005721 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 670487005722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005723 dimer interface [polypeptide binding]; other site 670487005724 conserved gate region; other site 670487005725 ABC-ATPase subunit interface; other site 670487005726 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 670487005727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005728 dimer interface [polypeptide binding]; other site 670487005729 conserved gate region; other site 670487005730 putative PBP binding loops; other site 670487005731 ABC-ATPase subunit interface; other site 670487005732 PBP superfamily domain; Region: PBP_like_2; cl17296 670487005733 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 670487005734 PhoU domain; Region: PhoU; pfam01895 670487005735 PhoU domain; Region: PhoU; pfam01895 670487005736 PAS domain; Region: PAS_8; pfam13188 670487005737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487005738 ATP binding site [chemical binding]; other site 670487005739 Mg2+ binding site [ion binding]; other site 670487005740 G-X-G motif; other site 670487005741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487005742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487005743 active site 670487005744 phosphorylation site [posttranslational modification] 670487005745 intermolecular recognition site; other site 670487005746 dimerization interface [polypeptide binding]; other site 670487005747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487005748 DNA binding site [nucleotide binding] 670487005749 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 670487005750 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 670487005751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 670487005752 Beta-Casp domain; Region: Beta-Casp; smart01027 670487005753 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 670487005754 Histidine kinase; Region: HisKA_3; pfam07730 670487005755 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 670487005756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487005757 ATP binding site [chemical binding]; other site 670487005758 Mg2+ binding site [ion binding]; other site 670487005759 G-X-G motif; other site 670487005760 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 670487005761 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 670487005762 multifunctional aminopeptidase A; Provisional; Region: PRK00913 670487005763 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 670487005764 interface (dimer of trimers) [polypeptide binding]; other site 670487005765 Substrate-binding/catalytic site; other site 670487005766 Zn-binding sites [ion binding]; other site 670487005767 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 670487005768 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 670487005769 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 670487005770 Ligand Binding Site [chemical binding]; other site 670487005771 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 670487005772 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 670487005773 N-acetyl-D-glucosamine binding site [chemical binding]; other site 670487005774 catalytic residue [active] 670487005775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 670487005776 Response regulator receiver domain; Region: Response_reg; pfam00072 670487005777 active site 670487005778 phosphorylation site [posttranslational modification] 670487005779 intermolecular recognition site; other site 670487005780 dimerization interface [polypeptide binding]; other site 670487005781 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 670487005782 Transglycosylase; Region: Transgly; pfam00912 670487005783 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 670487005784 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 670487005785 metal binding site 2 [ion binding]; metal-binding site 670487005786 putative DNA binding helix; other site 670487005787 metal binding site 1 [ion binding]; metal-binding site 670487005788 dimer interface [polypeptide binding]; other site 670487005789 structural Zn2+ binding site [ion binding]; other site 670487005790 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 670487005791 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 670487005792 active site 670487005793 PHP Thumb interface [polypeptide binding]; other site 670487005794 metal binding site [ion binding]; metal-binding site 670487005795 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 670487005796 generic binding surface II; other site 670487005797 generic binding surface I; other site 670487005798 Methyltransferase domain; Region: Methyltransf_23; pfam13489 670487005799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487005800 S-adenosylmethionine binding site [chemical binding]; other site 670487005801 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 670487005802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 670487005803 substrate binding pocket [chemical binding]; other site 670487005804 membrane-bound complex binding site; other site 670487005805 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 670487005806 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 670487005807 Walker A/P-loop; other site 670487005808 ATP binding site [chemical binding]; other site 670487005809 Q-loop/lid; other site 670487005810 ABC transporter signature motif; other site 670487005811 Walker B; other site 670487005812 D-loop; other site 670487005813 H-loop/switch region; other site 670487005814 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 670487005815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005816 dimer interface [polypeptide binding]; other site 670487005817 conserved gate region; other site 670487005818 putative PBP binding loops; other site 670487005819 ABC-ATPase subunit interface; other site 670487005820 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 670487005821 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 670487005822 Cna protein B-type domain; Region: Cna_B_2; pfam13715 670487005823 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 670487005824 active site 670487005825 catalytic residues [active] 670487005826 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 670487005827 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 670487005828 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 670487005829 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 670487005830 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 670487005831 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 670487005832 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 670487005833 RNA/DNA hybrid binding site [nucleotide binding]; other site 670487005834 active site 670487005835 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 670487005836 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 670487005837 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 670487005838 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 670487005839 DctM-like transporters; Region: DctM; pfam06808 670487005840 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 670487005841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487005842 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 670487005843 Ligand Binding Site [chemical binding]; other site 670487005844 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 670487005845 dihydropteroate synthase; Region: DHPS; TIGR01496 670487005846 substrate binding pocket [chemical binding]; other site 670487005847 dimer interface [polypeptide binding]; other site 670487005848 inhibitor binding site; inhibition site 670487005849 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 670487005850 active site 670487005851 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 670487005852 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 670487005853 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 670487005854 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 670487005855 Soluble P-type ATPase [General function prediction only]; Region: COG4087 670487005856 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 670487005857 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 670487005858 catalytic center binding site [active] 670487005859 ATP binding site [chemical binding]; other site 670487005860 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 670487005861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 670487005862 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 670487005863 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 670487005864 metal binding site 2 [ion binding]; metal-binding site 670487005865 putative DNA binding helix; other site 670487005866 metal binding site 1 [ion binding]; metal-binding site 670487005867 dimer interface [polypeptide binding]; other site 670487005868 structural Zn2+ binding site [ion binding]; other site 670487005869 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 670487005870 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 670487005871 domain interfaces; other site 670487005872 active site 670487005873 Beta-propeller repeat; Region: SBBP; pfam06739 670487005874 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 670487005875 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 670487005876 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 670487005877 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 670487005878 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 670487005879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005880 dimer interface [polypeptide binding]; other site 670487005881 conserved gate region; other site 670487005882 putative PBP binding loops; other site 670487005883 ABC-ATPase subunit interface; other site 670487005884 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 670487005885 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 670487005886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487005887 putative PBP binding loops; other site 670487005888 dimer interface [polypeptide binding]; other site 670487005889 ABC-ATPase subunit interface; other site 670487005890 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 670487005891 active site 670487005892 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 670487005893 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 670487005894 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 670487005895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 670487005896 motif II; other site 670487005897 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 670487005898 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 670487005899 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 670487005900 chaperone protein DnaJ; Provisional; Region: PRK14299 670487005901 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 670487005902 HSP70 interaction site [polypeptide binding]; other site 670487005903 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 670487005904 substrate binding site [polypeptide binding]; other site 670487005905 dimer interface [polypeptide binding]; other site 670487005906 GrpE; Region: GrpE; pfam01025 670487005907 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 670487005908 dimer interface [polypeptide binding]; other site 670487005909 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 670487005910 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 670487005911 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 670487005912 nucleotide binding site [chemical binding]; other site 670487005913 NEF interaction site [polypeptide binding]; other site 670487005914 SBD interface [polypeptide binding]; other site 670487005915 FtsH Extracellular; Region: FtsH_ext; pfam06480 670487005916 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 670487005917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487005918 Walker A motif; other site 670487005919 ATP binding site [chemical binding]; other site 670487005920 Walker B motif; other site 670487005921 arginine finger; other site 670487005922 Peptidase family M41; Region: Peptidase_M41; pfam01434 670487005923 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 670487005924 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 670487005925 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 670487005926 dimer interface [polypeptide binding]; other site 670487005927 active site 670487005928 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 670487005929 dimer interface [polypeptide binding]; other site 670487005930 active site 670487005931 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 670487005932 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 670487005933 active site 670487005934 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 670487005935 Carboxylesterase family; Region: COesterase; pfam00135 670487005936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 670487005937 substrate binding pocket [chemical binding]; other site 670487005938 catalytic triad [active] 670487005939 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 670487005940 Mechanosensitive ion channel; Region: MS_channel; pfam00924 670487005941 putative phosphate acyltransferase; Provisional; Region: PRK05331 670487005942 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 670487005943 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487005944 catalytic residues [active] 670487005945 Domain of unknown function (DUF309); Region: DUF309; pfam03745 670487005946 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 670487005947 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 670487005948 FMN binding site [chemical binding]; other site 670487005949 substrate binding site [chemical binding]; other site 670487005950 putative catalytic residue [active] 670487005951 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 670487005952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487005953 FeS/SAM binding site; other site 670487005954 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 670487005955 GTP-binding protein YchF; Reviewed; Region: PRK09601 670487005956 YchF GTPase; Region: YchF; cd01900 670487005957 G1 box; other site 670487005958 GTP/Mg2+ binding site [chemical binding]; other site 670487005959 Switch I region; other site 670487005960 G2 box; other site 670487005961 Switch II region; other site 670487005962 G3 box; other site 670487005963 G4 box; other site 670487005964 G5 box; other site 670487005965 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 670487005966 Cytochrome c [Energy production and conversion]; Region: COG3258 670487005967 Cytochrome c; Region: Cytochrom_C; pfam00034 670487005968 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487005969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487005970 active site 670487005971 phosphorylation site [posttranslational modification] 670487005972 intermolecular recognition site; other site 670487005973 dimerization interface [polypeptide binding]; other site 670487005974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487005975 DNA binding site [nucleotide binding] 670487005976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 670487005977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487005978 dimer interface [polypeptide binding]; other site 670487005979 phosphorylation site [posttranslational modification] 670487005980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487005981 ATP binding site [chemical binding]; other site 670487005982 Mg2+ binding site [ion binding]; other site 670487005983 G-X-G motif; other site 670487005984 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 670487005985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487005986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 670487005987 glutamate racemase; Provisional; Region: PRK00865 670487005988 ribonuclease PH; Reviewed; Region: rph; PRK00173 670487005989 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 670487005990 oligomer interface [polypeptide binding]; other site 670487005991 RNA binding site [nucleotide binding]; other site 670487005992 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 670487005993 active site 670487005994 dimerization interface [polypeptide binding]; other site 670487005995 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 670487005996 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 670487005997 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 670487005998 Helix-turn-helix domain; Region: HTH_25; pfam13413 670487005999 PEGA domain; Region: PEGA; pfam08308 670487006000 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 670487006001 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 670487006002 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 670487006003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487006004 FeS/SAM binding site; other site 670487006005 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 670487006006 TrkA-N domain; Region: TrkA_N; pfam02254 670487006007 TrkA-C domain; Region: TrkA_C; pfam02080 670487006008 TrkA-N domain; Region: TrkA_N; pfam02254 670487006009 TrkA-C domain; Region: TrkA_C; pfam02080 670487006010 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 670487006011 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 670487006012 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 670487006013 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 670487006014 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 670487006015 Predicted permeases [General function prediction only]; Region: COG0795 670487006016 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 670487006017 Predicted permeases [General function prediction only]; Region: COG0795 670487006018 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 670487006019 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 670487006020 A new structural DNA glycosylase; Region: AlkD_like; cd06561 670487006021 active site 670487006022 DsrE/DsrF-like family; Region: DrsE; cl00672 670487006023 FtsH Extracellular; Region: FtsH_ext; pfam06480 670487006024 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 670487006025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487006026 Walker A motif; other site 670487006027 ATP binding site [chemical binding]; other site 670487006028 Walker B motif; other site 670487006029 arginine finger; other site 670487006030 Peptidase family M41; Region: Peptidase_M41; pfam01434 670487006031 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 670487006032 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 670487006033 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 670487006034 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 670487006035 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 670487006036 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 670487006037 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 670487006038 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 670487006039 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 670487006040 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 670487006041 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 670487006042 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 670487006043 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 670487006044 Domain of unknown function DUF87; Region: DUF87; pfam01935 670487006045 AAA-like domain; Region: AAA_10; pfam12846 670487006046 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 670487006047 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 670487006048 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 670487006049 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 670487006050 putative active site [active] 670487006051 catalytic residue [active] 670487006052 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 670487006053 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 670487006054 5S rRNA interface [nucleotide binding]; other site 670487006055 CTC domain interface [polypeptide binding]; other site 670487006056 L16 interface [polypeptide binding]; other site 670487006057 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 670487006058 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 670487006059 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 670487006060 active site 670487006061 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 670487006062 S-ribosylhomocysteinase; Provisional; Region: PRK02260 670487006063 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 670487006064 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 670487006065 Cl- selectivity filter; other site 670487006066 Cl- binding residues [ion binding]; other site 670487006067 pore gating glutamate residue; other site 670487006068 dimer interface [polypeptide binding]; other site 670487006069 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 670487006070 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 670487006071 ATP binding site [chemical binding]; other site 670487006072 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 670487006073 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 670487006074 dimer interface [polypeptide binding]; other site 670487006075 active site 670487006076 heme binding site [chemical binding]; other site 670487006077 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 670487006078 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14855 670487006079 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 670487006080 metal binding site 2 [ion binding]; metal-binding site 670487006081 putative DNA binding helix; other site 670487006082 metal binding site 1 [ion binding]; metal-binding site 670487006083 dimer interface [polypeptide binding]; other site 670487006084 structural Zn2+ binding site [ion binding]; other site 670487006085 Ferritin-like domain; Region: Ferritin; pfam00210 670487006086 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 670487006087 dinuclear metal binding motif [ion binding]; other site 670487006088 ectoine utilization protein EutC; Validated; Region: PRK08291 670487006089 Bacterial transcriptional activator domain; Region: BTAD; smart01043 670487006090 AAA ATPase domain; Region: AAA_16; pfam13191 670487006091 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 670487006092 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 670487006093 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 670487006094 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 670487006095 FMN binding site [chemical binding]; other site 670487006096 dimer interface [polypeptide binding]; other site 670487006097 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 670487006098 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 670487006099 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 670487006100 TPP-binding site; other site 670487006101 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 670487006102 PYR/PP interface [polypeptide binding]; other site 670487006103 dimer interface [polypeptide binding]; other site 670487006104 TPP binding site [chemical binding]; other site 670487006105 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 670487006106 recombination protein F; Provisional; Region: recF; PRK14079 670487006107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487006108 Walker A/P-loop; other site 670487006109 ATP binding site [chemical binding]; other site 670487006110 Q-loop/lid; other site 670487006111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487006112 ABC transporter signature motif; other site 670487006113 Walker B; other site 670487006114 D-loop; other site 670487006115 H-loop/switch region; other site 670487006116 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 670487006117 putative ADP-ribose binding site [chemical binding]; other site 670487006118 Protein of unknown function (DUF721); Region: DUF721; pfam05258 670487006119 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 670487006120 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 670487006121 homodimer interface [polypeptide binding]; other site 670487006122 substrate-cofactor binding pocket; other site 670487006123 catalytic residue [active] 670487006124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487006125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 670487006126 putative substrate translocation pore; other site 670487006127 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 670487006128 Ferritin-like domain; Region: Ferritin; pfam00210 670487006129 ferroxidase diiron center [ion binding]; other site 670487006130 methionine sulfoxide reductase A; Provisional; Region: PRK14054 670487006131 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 670487006132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 670487006133 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 670487006134 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 670487006135 NAD(P) binding site [chemical binding]; other site 670487006136 catalytic residues [active] 670487006137 short chain dehydrogenase; Provisional; Region: PRK06057 670487006138 classical (c) SDRs; Region: SDR_c; cd05233 670487006139 NAD(P) binding site [chemical binding]; other site 670487006140 active site 670487006141 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 670487006142 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 670487006143 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 670487006144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 670487006145 Walker A/P-loop; other site 670487006146 ATP binding site [chemical binding]; other site 670487006147 Q-loop/lid; other site 670487006148 ABC transporter signature motif; other site 670487006149 Walker B; other site 670487006150 D-loop; other site 670487006151 H-loop/switch region; other site 670487006152 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468 670487006153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 670487006154 FeS/SAM binding site; other site 670487006155 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 670487006156 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 670487006157 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487006158 catalytic residues [active] 670487006159 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 670487006160 active site 670487006161 catalytic site [active] 670487006162 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 670487006163 MutS domain III; Region: MutS_III; pfam05192 670487006164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487006165 Walker A/P-loop; other site 670487006166 ATP binding site [chemical binding]; other site 670487006167 Q-loop/lid; other site 670487006168 ABC transporter signature motif; other site 670487006169 Walker B; other site 670487006170 D-loop; other site 670487006171 H-loop/switch region; other site 670487006172 Smr domain; Region: Smr; pfam01713 670487006173 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 670487006174 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 670487006175 3D domain; Region: 3D; cl01439 670487006176 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 670487006177 DAK2 domain; Region: Dak2; pfam02734 670487006178 Asp23 family; Region: Asp23; pfam03780 670487006179 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 670487006180 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 670487006181 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 670487006182 hexamer interface [polypeptide binding]; other site 670487006183 ligand binding site [chemical binding]; other site 670487006184 putative active site [active] 670487006185 NAD(P) binding site [chemical binding]; other site 670487006186 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 670487006187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 670487006188 putative DNA binding site [nucleotide binding]; other site 670487006189 putative Zn2+ binding site [ion binding]; other site 670487006190 AsnC family; Region: AsnC_trans_reg; pfam01037 670487006191 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 670487006192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 670487006193 substrate binding site [chemical binding]; other site 670487006194 oxyanion hole (OAH) forming residues; other site 670487006195 trimer interface [polypeptide binding]; other site 670487006196 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 670487006197 Bacterial Ig-like domain; Region: Big_5; pfam13205 670487006198 Bacterial Ig-like domain; Region: Big_5; pfam13205 670487006199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487006200 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 670487006201 NAD(P) binding site [chemical binding]; other site 670487006202 active site 670487006203 serine O-acetyltransferase; Region: cysE; TIGR01172 670487006204 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 670487006205 trimer interface [polypeptide binding]; other site 670487006206 active site 670487006207 substrate binding site [chemical binding]; other site 670487006208 CoA binding site [chemical binding]; other site 670487006209 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 670487006210 Predicted dehydrogenase [General function prediction only]; Region: COG5322 670487006211 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 670487006212 NAD(P) binding pocket [chemical binding]; other site 670487006213 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 670487006214 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 670487006215 23S rRNA binding site [nucleotide binding]; other site 670487006216 L21 binding site [polypeptide binding]; other site 670487006217 L13 binding site [polypeptide binding]; other site 670487006218 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 670487006219 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 670487006220 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 670487006221 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 670487006222 futalosine nucleosidase; Region: fut_nucase; TIGR03664 670487006223 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 670487006224 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 670487006225 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 670487006226 G1 box; other site 670487006227 GTP/Mg2+ binding site [chemical binding]; other site 670487006228 Switch I region; other site 670487006229 G2 box; other site 670487006230 G3 box; other site 670487006231 Switch II region; other site 670487006232 G4 box; other site 670487006233 G5 box; other site 670487006234 Nucleoside recognition; Region: Gate; pfam07670 670487006235 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 670487006236 FeoA domain; Region: FeoA; pfam04023 670487006237 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 670487006238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 670487006239 RNA binding surface [nucleotide binding]; other site 670487006240 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 670487006241 active site 670487006242 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 670487006243 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 670487006244 RNA binding site [nucleotide binding]; other site 670487006245 active site 670487006246 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 670487006247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 670487006248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 670487006249 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 670487006250 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 670487006251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 670487006252 CAAX protease self-immunity; Region: Abi; pfam02517 670487006253 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 670487006254 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 670487006255 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 670487006256 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 670487006257 four helix bundle protein; Region: TIGR02436 670487006258 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 670487006259 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 670487006260 glutamine binding [chemical binding]; other site 670487006261 catalytic triad [active] 670487006262 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 670487006263 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 670487006264 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 670487006265 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 670487006266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487006267 ATP binding site [chemical binding]; other site 670487006268 Mg2+ binding site [ion binding]; other site 670487006269 G-X-G motif; other site 670487006270 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 670487006271 anchoring element; other site 670487006272 dimer interface [polypeptide binding]; other site 670487006273 ATP binding site [chemical binding]; other site 670487006274 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 670487006275 active site 670487006276 putative metal-binding site [ion binding]; other site 670487006277 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 670487006278 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 670487006279 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 670487006280 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 670487006281 catalytic loop [active] 670487006282 iron binding site [ion binding]; other site 670487006283 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 670487006284 4Fe-4S binding domain; Region: Fer4; cl02805 670487006285 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 670487006286 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 670487006287 [4Fe-4S] binding site [ion binding]; other site 670487006288 molybdopterin cofactor binding site; other site 670487006289 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 670487006290 molybdopterin cofactor binding site; other site 670487006291 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 670487006292 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 670487006293 NAD binding site [chemical binding]; other site 670487006294 homotetramer interface [polypeptide binding]; other site 670487006295 homodimer interface [polypeptide binding]; other site 670487006296 substrate binding site [chemical binding]; other site 670487006297 active site 670487006298 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 670487006299 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 670487006300 dimer interface [polypeptide binding]; other site 670487006301 putative functional site; other site 670487006302 putative MPT binding site; other site 670487006303 AAA ATPase domain; Region: AAA_15; pfam13175 670487006304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487006305 Walker A/P-loop; other site 670487006306 ATP binding site [chemical binding]; other site 670487006307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 670487006308 ABC transporter signature motif; other site 670487006309 Walker B; other site 670487006310 D-loop; other site 670487006311 H-loop/switch region; other site 670487006312 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 670487006313 putative active site [active] 670487006314 putative metal-binding site [ion binding]; other site 670487006315 DNA topoisomerase I; Validated; Region: PRK06599 670487006316 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 670487006317 active site 670487006318 interdomain interaction site; other site 670487006319 putative metal-binding site [ion binding]; other site 670487006320 nucleotide binding site [chemical binding]; other site 670487006321 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 670487006322 domain I; other site 670487006323 DNA binding groove [nucleotide binding] 670487006324 phosphate binding site [ion binding]; other site 670487006325 domain II; other site 670487006326 domain III; other site 670487006327 nucleotide binding site [chemical binding]; other site 670487006328 catalytic site [active] 670487006329 domain IV; other site 670487006330 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 670487006331 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 670487006332 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 670487006333 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 670487006334 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487006335 Cytochrome c; Region: Cytochrom_C; pfam00034 670487006336 Protein of unknown function (DUF502); Region: DUF502; cl01107 670487006337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 670487006338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487006339 Walker A/P-loop; other site 670487006340 ATP binding site [chemical binding]; other site 670487006341 Q-loop/lid; other site 670487006342 ABC transporter signature motif; other site 670487006343 Walker B; other site 670487006344 D-loop; other site 670487006345 H-loop/switch region; other site 670487006346 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 670487006347 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 670487006348 trimer interface [polypeptide binding]; other site 670487006349 dimer interface [polypeptide binding]; other site 670487006350 putative active site [active] 670487006351 Transcriptional regulators [Transcription]; Region: GntR; COG1802 670487006352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 670487006353 DNA-binding site [nucleotide binding]; DNA binding site 670487006354 Proline dehydrogenase; Region: Pro_dh; cl03282 670487006355 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 670487006356 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 670487006357 Glutamate binding site [chemical binding]; other site 670487006358 homodimer interface [polypeptide binding]; other site 670487006359 NAD binding site [chemical binding]; other site 670487006360 catalytic residues [active] 670487006361 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 670487006362 active site 670487006363 NTP binding site [chemical binding]; other site 670487006364 metal binding triad [ion binding]; metal-binding site 670487006365 antibiotic binding site [chemical binding]; other site 670487006366 CAAX protease self-immunity; Region: Abi; pfam02517 670487006367 FOG: CBS domain [General function prediction only]; Region: COG0517 670487006368 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 670487006369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 670487006370 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 670487006371 Walker A motif; other site 670487006372 ATP binding site [chemical binding]; other site 670487006373 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 670487006374 Walker B motif; other site 670487006375 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 670487006376 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 670487006377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487006378 NAD(P) binding site [chemical binding]; other site 670487006379 active site 670487006380 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 670487006381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 670487006382 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 670487006383 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 670487006384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487006385 catalytic residues [active] 670487006386 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 670487006387 putative homodimer interface [polypeptide binding]; other site 670487006388 putative homotetramer interface [polypeptide binding]; other site 670487006389 allosteric switch controlling residues; other site 670487006390 putative metal binding site [ion binding]; other site 670487006391 putative homodimer-homodimer interface [polypeptide binding]; other site 670487006392 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 670487006393 metal-binding site [ion binding] 670487006394 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 670487006395 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487006396 catalytic residues [active] 670487006397 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 670487006398 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487006399 catalytic residues [active] 670487006400 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 670487006401 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 670487006402 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 670487006403 catalytic residues [active] 670487006404 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 670487006405 Low molecular weight phosphatase family; Region: LMWPc; cd00115 670487006406 active site 670487006407 Fructosamine kinase; Region: Fructosamin_kin; cl17579 670487006408 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 670487006409 Right handed beta helix region; Region: Beta_helix; pfam13229 670487006410 Domain of unknown function DUF11; Region: DUF11; pfam01345 670487006411 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 670487006412 Domain of unknown function DUF11; Region: DUF11; cl17728 670487006413 Domain of unknown function DUF11; Region: DUF11; pfam01345 670487006414 Domain of unknown function DUF11; Region: DUF11; cl17728 670487006415 Domain of unknown function DUF11; Region: DUF11; cl17728 670487006416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 670487006417 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 670487006418 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 670487006419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 670487006420 Walker A/P-loop; other site 670487006421 ATP binding site [chemical binding]; other site 670487006422 ABC transporter signature motif; other site 670487006423 Walker B; other site 670487006424 D-loop; other site 670487006425 H-loop/switch region; other site 670487006426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 670487006427 PBP superfamily domain; Region: PBP_like_2; pfam12849 670487006428 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 670487006429 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 670487006430 RNA binding site [nucleotide binding]; other site 670487006431 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 670487006432 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 670487006433 active site 670487006434 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 670487006435 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 670487006436 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 670487006437 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 670487006438 active site 670487006439 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 670487006440 active site 670487006441 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 670487006442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 670487006443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 670487006444 catalytic residue [active] 670487006445 Peptidase C26; Region: Peptidase_C26; pfam07722 670487006446 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 670487006447 catalytic triad [active] 670487006448 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 670487006449 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 670487006450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487006451 dimer interface [polypeptide binding]; other site 670487006452 conserved gate region; other site 670487006453 putative PBP binding loops; other site 670487006454 ABC-ATPase subunit interface; other site 670487006455 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 670487006456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487006457 dimer interface [polypeptide binding]; other site 670487006458 conserved gate region; other site 670487006459 putative PBP binding loops; other site 670487006460 ABC-ATPase subunit interface; other site 670487006461 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 670487006462 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 670487006463 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 670487006464 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 670487006465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487006466 dimer interface [polypeptide binding]; other site 670487006467 conserved gate region; other site 670487006468 putative PBP binding loops; other site 670487006469 ABC-ATPase subunit interface; other site 670487006470 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 670487006471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 670487006472 putative PBP binding loops; other site 670487006473 dimer interface [polypeptide binding]; other site 670487006474 ABC-ATPase subunit interface; other site 670487006475 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 670487006476 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 670487006477 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 670487006478 classical (c) SDRs; Region: SDR_c; cd05233 670487006479 NAD(P) binding site [chemical binding]; other site 670487006480 active site 670487006481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487006482 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 670487006483 NAD(P) binding site [chemical binding]; other site 670487006484 active site 670487006485 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 670487006486 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 670487006487 putative dimer interface [polypeptide binding]; other site 670487006488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 670487006489 rod shape-determining protein MreB; Provisional; Region: PRK13927 670487006490 MreB and similar proteins; Region: MreB_like; cd10225 670487006491 nucleotide binding site [chemical binding]; other site 670487006492 Mg binding site [ion binding]; other site 670487006493 putative protofilament interaction site [polypeptide binding]; other site 670487006494 RodZ interaction site [polypeptide binding]; other site 670487006495 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 670487006496 Predicted permeases [General function prediction only]; Region: COG0795 670487006497 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 670487006498 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 670487006499 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 670487006500 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 670487006501 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 670487006502 NodB motif; other site 670487006503 putative active site [active] 670487006504 putative catalytic site [active] 670487006505 putative Zn binding site [ion binding]; other site 670487006506 O-Antigen ligase; Region: Wzy_C; cl04850 670487006507 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 670487006508 KaiC; Region: KaiC; pfam06745 670487006509 Walker A motif; other site 670487006510 ATP binding site [chemical binding]; other site 670487006511 Walker B motif; other site 670487006512 Methyltransferase domain; Region: Methyltransf_23; pfam13489 670487006513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487006514 S-adenosylmethionine binding site [chemical binding]; other site 670487006515 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 670487006516 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 670487006517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 670487006518 putative DNA binding site [nucleotide binding]; other site 670487006519 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 670487006520 putative Zn2+ binding site [ion binding]; other site 670487006521 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 670487006522 BtpA family; Region: BtpA; cl00440 670487006523 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 670487006524 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 670487006525 N- and C-terminal domain interface [polypeptide binding]; other site 670487006526 putative active site [active] 670487006527 MgATP binding site [chemical binding]; other site 670487006528 catalytic site [active] 670487006529 metal binding site [ion binding]; metal-binding site 670487006530 putative xylulose binding site [chemical binding]; other site 670487006531 putative homodimer interface [polypeptide binding]; other site 670487006532 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 670487006533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487006534 NAD(P) binding site [chemical binding]; other site 670487006535 active site 670487006536 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 670487006537 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 670487006538 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 670487006539 metal binding site [ion binding]; metal-binding site 670487006540 substrate binding pocket [chemical binding]; other site 670487006541 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 670487006542 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 670487006543 putative metal binding site [ion binding]; other site 670487006544 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 670487006545 CoenzymeA binding site [chemical binding]; other site 670487006546 subunit interaction site [polypeptide binding]; other site 670487006547 PHB binding site; other site 670487006548 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 670487006549 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 670487006550 Peptidase family M23; Region: Peptidase_M23; pfam01551 670487006551 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 670487006552 aspartate racemase; Region: asp_race; TIGR00035 670487006553 primosomal protein N' Region: priA; TIGR00595 670487006554 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 670487006555 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 670487006556 putative active site [active] 670487006557 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 670487006558 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 670487006559 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 670487006560 active site 670487006561 catalytic site [active] 670487006562 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 670487006563 active site 670487006564 multimer interface [polypeptide binding]; other site 670487006565 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 670487006566 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 670487006567 active site 670487006568 catalytic tetrad [active] 670487006569 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 670487006570 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 670487006571 Walker A/P-loop; other site 670487006572 ATP binding site [chemical binding]; other site 670487006573 Q-loop/lid; other site 670487006574 ABC transporter signature motif; other site 670487006575 Walker B; other site 670487006576 D-loop; other site 670487006577 H-loop/switch region; other site 670487006578 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 670487006579 ABC-2 type transporter; Region: ABC2_membrane; cl17235 670487006580 Transposase IS200 like; Region: Y1_Tnp; cl00848 670487006581 aspartate aminotransferase; Provisional; Region: PRK05764 670487006582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 670487006583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487006584 homodimer interface [polypeptide binding]; other site 670487006585 catalytic residue [active] 670487006586 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 670487006587 diiron binding motif [ion binding]; other site 670487006588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 670487006589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 670487006590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487006591 dimer interface [polypeptide binding]; other site 670487006592 phosphorylation site [posttranslational modification] 670487006593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487006594 ATP binding site [chemical binding]; other site 670487006595 Mg2+ binding site [ion binding]; other site 670487006596 G-X-G motif; other site 670487006597 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 670487006598 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 670487006599 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 670487006600 Peptidase family M23; Region: Peptidase_M23; pfam01551 670487006601 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 670487006602 Domain of unknown function DUF20; Region: UPF0118; pfam01594 670487006603 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 670487006604 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 670487006605 dimer interface [polypeptide binding]; other site 670487006606 acyl-activating enzyme (AAE) consensus motif; other site 670487006607 putative active site [active] 670487006608 AMP binding site [chemical binding]; other site 670487006609 putative CoA binding site [chemical binding]; other site 670487006610 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 670487006611 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 670487006612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 670487006613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 670487006614 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 670487006615 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 670487006616 ligand binding site [chemical binding]; other site 670487006617 flexible hinge region; other site 670487006618 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 670487006619 putative switch regulator; other site 670487006620 non-specific DNA interactions [nucleotide binding]; other site 670487006621 DNA binding site [nucleotide binding] 670487006622 sequence specific DNA binding site [nucleotide binding]; other site 670487006623 putative cAMP binding site [chemical binding]; other site 670487006624 EVE domain; Region: EVE; cl00728 670487006625 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 670487006626 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487006627 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 670487006628 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 670487006629 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 670487006630 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 670487006631 Cytochrome c; Region: Cytochrom_C; pfam00034 670487006632 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 670487006633 ATP cone domain; Region: ATP-cone; pfam03477 670487006634 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 670487006635 classical (c) SDRs; Region: SDR_c; cd05233 670487006636 NAD(P) binding site [chemical binding]; other site 670487006637 active site 670487006638 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 670487006639 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 670487006640 putative acyl-acceptor binding pocket; other site 670487006641 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 670487006642 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 670487006643 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 670487006644 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 670487006645 substrate binding site [chemical binding]; other site 670487006646 ATP binding site [chemical binding]; other site 670487006647 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 670487006648 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 670487006649 minor groove reading motif; other site 670487006650 helix-hairpin-helix signature motif; other site 670487006651 substrate binding pocket [chemical binding]; other site 670487006652 active site 670487006653 Isochorismatase family; Region: Isochorismatase; pfam00857 670487006654 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 670487006655 catalytic triad [active] 670487006656 conserved cis-peptide bond; other site 670487006657 Biotin operon repressor [Transcription]; Region: BirA; COG1654 670487006658 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 670487006659 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 670487006660 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 670487006661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 670487006662 TPR repeat; Region: TPR_11; pfam13414 670487006663 binding surface 670487006664 TPR motif; other site 670487006665 Tetratricopeptide repeat; Region: TPR_6; pfam13174 670487006666 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 670487006667 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 670487006668 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 670487006669 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 670487006670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 670487006671 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 670487006672 putative substrate translocation pore; other site 670487006673 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 670487006674 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 670487006675 substrate binding site; other site 670487006676 metal-binding site 670487006677 Oligomer interface; other site 670487006678 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 670487006679 putative trimer interface [polypeptide binding]; other site 670487006680 putative CoA binding site [chemical binding]; other site 670487006681 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 670487006682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 670487006683 NAD(P) binding site [chemical binding]; other site 670487006684 active site 670487006685 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 670487006686 Bacterial sugar transferase; Region: Bac_transf; pfam02397 670487006687 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 670487006688 O-Antigen ligase; Region: Wzy_C; pfam04932 670487006689 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 670487006690 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 670487006691 pseudaminic acid synthase; Region: PseI; TIGR03586 670487006692 NeuB family; Region: NeuB; pfam03102 670487006693 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 670487006694 NeuB binding interface [polypeptide binding]; other site 670487006695 putative substrate binding site [chemical binding]; other site 670487006696 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 670487006697 ligand binding site; other site 670487006698 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 670487006699 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 670487006700 inhibitor-cofactor binding pocket; inhibition site 670487006701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 670487006702 catalytic residue [active] 670487006703 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 670487006704 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 670487006705 NAD(P) binding site [chemical binding]; other site 670487006706 homodimer interface [polypeptide binding]; other site 670487006707 substrate binding site [chemical binding]; other site 670487006708 active site 670487006709 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 670487006710 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 670487006711 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 670487006712 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 670487006713 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 670487006714 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 670487006715 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 670487006716 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 670487006717 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 670487006718 molybdopterin cofactor binding site [chemical binding]; other site 670487006719 substrate binding site [chemical binding]; other site 670487006720 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 670487006721 molybdopterin cofactor binding site; other site 670487006722 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 670487006723 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 670487006724 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 670487006725 putative active site [active] 670487006726 substrate binding site [chemical binding]; other site 670487006727 putative cosubstrate binding site; other site 670487006728 catalytic site [active] 670487006729 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 670487006730 substrate binding site [chemical binding]; other site 670487006731 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 670487006732 active site 670487006733 catalytic residues [active] 670487006734 metal binding site [ion binding]; metal-binding site 670487006735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 670487006736 Uncharacterized conserved protein [Function unknown]; Region: COG1624 670487006737 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 670487006738 phosphopentomutase; Provisional; Region: PRK05362 670487006739 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 670487006740 DNA polymerase IV; Reviewed; Region: PRK03103 670487006741 Y-family of DNA polymerases; Region: PolY; cd00424 670487006742 active site 670487006743 DNA binding site [nucleotide binding] 670487006744 impB/mucB/samB family C-terminal; Region: IMS_C; pfam11799 670487006745 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 670487006746 PAS domain; Region: PAS; smart00091 670487006747 PAS fold; Region: PAS_3; pfam08447 670487006748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 670487006749 putative active site [active] 670487006750 heme pocket [chemical binding]; other site 670487006751 PAS domain S-box; Region: sensory_box; TIGR00229 670487006752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 670487006753 putative active site [active] 670487006754 heme pocket [chemical binding]; other site 670487006755 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 670487006756 GAF domain; Region: GAF_3; pfam13492 670487006757 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 670487006758 GAF domain; Region: GAF_3; pfam13492 670487006759 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 670487006760 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 670487006761 Zn2+ binding site [ion binding]; other site 670487006762 Mg2+ binding site [ion binding]; other site 670487006763 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 670487006764 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 670487006765 DNA binding residues [nucleotide binding] 670487006766 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 670487006767 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 670487006768 dimer interface [polypeptide binding]; other site 670487006769 catalytic residue [active] 670487006770 metal binding site [ion binding]; metal-binding site 670487006771 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 670487006772 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 670487006773 PYR/PP interface [polypeptide binding]; other site 670487006774 dimer interface [polypeptide binding]; other site 670487006775 TPP binding site [chemical binding]; other site 670487006776 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 670487006777 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 670487006778 TPP-binding site [chemical binding]; other site 670487006779 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 670487006780 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 670487006781 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 670487006782 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 670487006783 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 670487006784 acyl-activating enzyme (AAE) consensus motif; other site 670487006785 active site 670487006786 CoA binding site [chemical binding]; other site 670487006787 AMP binding site [chemical binding]; other site 670487006788 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 670487006789 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 670487006790 TM-ABC transporter signature motif; other site 670487006791 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 670487006792 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 670487006793 acyl-activating enzyme (AAE) consensus motif; other site 670487006794 putative AMP binding site [chemical binding]; other site 670487006795 putative active site [active] 670487006796 putative CoA binding site [chemical binding]; other site 670487006797 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 670487006798 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 670487006799 Walker A/P-loop; other site 670487006800 ATP binding site [chemical binding]; other site 670487006801 Q-loop/lid; other site 670487006802 ABC transporter signature motif; other site 670487006803 Walker B; other site 670487006804 D-loop; other site 670487006805 H-loop/switch region; other site 670487006806 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 670487006807 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 670487006808 Walker A/P-loop; other site 670487006809 ATP binding site [chemical binding]; other site 670487006810 Q-loop/lid; other site 670487006811 ABC transporter signature motif; other site 670487006812 Walker B; other site 670487006813 D-loop; other site 670487006814 H-loop/switch region; other site 670487006815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 670487006816 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 670487006817 TM-ABC transporter signature motif; other site 670487006818 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 670487006819 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 670487006820 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 670487006821 active site 670487006822 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 670487006823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 670487006824 active site 670487006825 phosphorylation site [posttranslational modification] 670487006826 intermolecular recognition site; other site 670487006827 dimerization interface [polypeptide binding]; other site 670487006828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 670487006829 DNA binding site [nucleotide binding] 670487006830 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 670487006831 acyl-activating enzyme (AAE) consensus motif; other site 670487006832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 670487006833 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 670487006834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 670487006835 phosphorylation site [posttranslational modification] 670487006836 dimer interface [polypeptide binding]; other site 670487006837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 670487006838 ATP binding site [chemical binding]; other site 670487006839 Mg2+ binding site [ion binding]; other site 670487006840 G-X-G motif; other site 670487006841 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 670487006842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 670487006843 non-specific DNA binding site [nucleotide binding]; other site 670487006844 salt bridge; other site 670487006845 sequence-specific DNA binding site [nucleotide binding]; other site 670487006846 4Fe-4S binding domain; Region: Fer4; pfam00037 670487006847 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 670487006848 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 670487006849 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 670487006850 Chorismate mutase type II; Region: CM_2; cl00693 670487006851 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 670487006852 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 670487006853 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 670487006854 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 670487006855 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 670487006856 Substrate binding site; other site 670487006857 Mg++ binding site; other site 670487006858 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 670487006859 active site 670487006860 substrate binding site [chemical binding]; other site 670487006861 CoA binding site [chemical binding]; other site 670487006862 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 670487006863 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 670487006864 Protein of unknown function (DUF456); Region: DUF456; pfam04306 670487006865 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 670487006866 EamA-like transporter family; Region: EamA; pfam00892 670487006867 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 670487006868 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 670487006869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 670487006870 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 670487006871 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 670487006872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 670487006873 ATP binding site [chemical binding]; other site 670487006874 putative Mg++ binding site [ion binding]; other site 670487006875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 670487006876 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 670487006877 nucleotide binding region [chemical binding]; other site 670487006878 ATP-binding site [chemical binding]; other site 670487006879 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 670487006880 YcfA-like protein; Region: YcfA; pfam07927 670487006881 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 670487006882 HicB family; Region: HicB; pfam05534 670487006883 LabA_like proteins; Region: LabA_like; cd06167 670487006884 putative metal binding site [ion binding]; other site 670487006885 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 670487006886 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 670487006887 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 670487006888 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 670487006889 Protein of unknown function (DUF499); Region: DUF499; pfam04465 670487006890 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 670487006891 Catalytic domain of Protein Kinases; Region: PKc; cd00180 670487006892 active site 670487006893 ATP binding site [chemical binding]; other site 670487006894 substrate binding site [chemical binding]; other site 670487006895 activation loop (A-loop); other site 670487006896 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 670487006897 active site 670487006898 PQQ-like domain; Region: PQQ_2; pfam13360 670487006899 Trp docking motif [polypeptide binding]; other site 670487006900 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 670487006901 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 670487006902 hinge; other site 670487006903 active site 670487006904 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 670487006905 CAAX protease self-immunity; Region: Abi; pfam02517 670487006906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 670487006907 S-adenosylmethionine binding site [chemical binding]; other site 670487006908 Transposase IS200 like; Region: Y1_Tnp; cl00848 670487006909 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 670487006910 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 670487006911 SdpI/YhfL protein family; Region: SdpI; pfam13630 670487006912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 670487006913 dimerization interface [polypeptide binding]; other site 670487006914 putative DNA binding site [nucleotide binding]; other site 670487006915 putative Zn2+ binding site [ion binding]; other site 670487006916 Right handed beta helix region; Region: Beta_helix; pfam13229 670487006917 YrhK-like protein; Region: YrhK; pfam14145 670487006918 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 670487006919 dimer interface [polypeptide binding]; other site 670487006920 substrate binding site [chemical binding]; other site 670487006921 metal binding sites [ion binding]; metal-binding site 670487006922 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 670487006923 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 670487006924 substrate binding pocket [chemical binding]; other site 670487006925 chain length determination region; other site 670487006926 substrate-Mg2+ binding site; other site 670487006927 catalytic residues [active] 670487006928 aspartate-rich region 1; other site 670487006929 active site lid residues [active] 670487006930 aspartate-rich region 2; other site 670487006931 Iron permease FTR1 family; Region: FTR1; cl00475 670487006932 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 670487006933 Helix-hairpin-helix motif; Region: HHH; pfam00633 670487006934 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 670487006935 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 670487006936 Competence protein; Region: Competence; cl00471 670487006937 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 670487006938 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 670487006939 ParB-like nuclease domain; Region: ParB; smart00470 670487006940 KorB domain; Region: KorB; pfam08535 670487006941 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 670487006942 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 670487006943 P-loop; other site 670487006944 Magnesium ion binding site [ion binding]; other site 670487006945 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 670487006946 Magnesium ion binding site [ion binding]; other site 670487006947 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 670487006948 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 670487006949 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 670487006950 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932