-- dump date 20140619_160416 -- class Genbank::CDS -- table cds_note -- id note NP_852783.2 MGA_0619; Soj [D] COG1192 ATPases involved in chromosome partitioning; pfam00991 ParA family ATPase; MGRL001 NP_852784.2 MGA_0621; MGRL002 NP_852785.1 MGA_0622; DnaA [L] COG0593 ATPase involved in DNA replication initiation; MGRL003 NP_852786.2 MGA_1322d; potential fragment of ABC transport component; [Q] COG1132 ABC-type multidrug/protein/lipid transport system, ATPase component; similar to MGA_1284; MGRL004a NP_852787.2 MGA_0625; potential fragment of ABC transport component; [V] COG1132 ABC-type multidrug transport system, ATPase and permease components; PS00890; similar to MGA_1285, MGA_0626 and MGA_1287; MGRL004b NP_852788.2 MGA_0626; ABC-type multidrug/protein/lipid transport system; [V] COG1132 ABC-type multidrug transport system, ATPase and permease components; PS00890; similar to MGA_1287, MGA_0625, MGA_1285; MGRL005 NP_852789.1 MGA_1323d; ribosomal protein L34 (RpL34); mgalr5; MGRL006 NP_852790.2 MGA_0630; ribonuclease P protein component (protein C5) COG0594; open at position 8550 but likely translational start at 8574; MGRL007 NP_852791.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria NP_852792.2 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_852793.1 MGA_0635; IspE [I] COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; MGRL010 NP_852794.2 MGA_0636; ArgS [J] COG0018 Arginyl-tRNA synthetase; MGRL011 NP_852795.2 MGA_0637; membrane nuclease; MGRL012 NP_852796.2 MGA_0641; GlpF [G] COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); MGRL013 NP_852797.2 Converts glycerol and ADP to glycerol-3-phosphate and ADP NP_852798.2 MGA_0646; potential Glycerol 3-P oxidase, homolog of glpD oxidase in M. pneumoniae; similar to [R] COG0579 Predicted dehydrogenase; pfam01266, DAO, FAD dependent oxidoreductase; MGRL015 NP_852799.2 MGA_0648; contains predicted signal peptidase II cleavage site; MGRL016 NP_852800.1 MGA_0649; similar to COG1528 Ferritin-like protein; similar to pfam00210 Ferritin-like domain; MGRL017 NP_852801.1 MGA_0650; GMP synthase PP-ATPase domain, [F] COG0519; cd01997, GMP_synthase_C, The C-terminal domain of GMP synthetase; C-terminus of PRK00074, guaA; MGRL018 NP_852802.2 MGA_0652; [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily; pfam00753, Lactamase_B, Metallo-beta-lactamase superfamily ; MGRL019 NP_852803.1 MGA_0654; similar in C-terminus to pfam02687, FtsX, Predicted permease; MGRL020 NP_852804.1 MGA_0655; [R] COG1136 ABC-type transport systems PS00890; MGRL021 NP_852805.2 MGA_0656; Contains a predicted signal peptidase I cleavage site; PDOC00013; MGRL022 NP_852806.2 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate NP_852807.2 MGA_0658; Hpt [F] COG0634 Hypoxanthine-guanine phosphoribosyltransferase; pfam00156, Pribosyltransferase Phosphoribosyl transferase domain; MGRL024 NP_852808.2 MGA_0659; HflB [O] COG0465 ATP-dependent Zn proteases; pfam01434, Peptidase_M41 Peptidase family M41; pfam00004, AAA ATPase family associated with various cellular activities (AAA); pfam06480, FtsH_ext, FtsH Extracellular. This domain is found in the FtsH family of proteins; smart00382, AAA ATPases associated with a variety of cellular activities; MGRL025 NP_852809.2 MGA_0661; similar to DAK1 [G] COG2376 Dihydroxyacetone kinase; pfam02734, Dak2, DAK2 domain. This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family; MGRL026 NP_852810.2 MGA_0662; contains 2 predicted transmembrane domains; MGRL027 NP_852811.2 MGA_0664; FruB [G] COG1925 Phosphotransferase system, HPr-related proteins; pfam00381, PTS-HPr, PTS HPr component phosphorylation site; MGRL028 NP_852812.2 MGA_0666; TktA [G] COG0021 Transketolase; COG3959, Transketolase, N-terminal subunit; COG3958, Transketolase, C-terminal subunit; pfam00456, Transketolase_N, Transketolase, thiamine diphosphate binding domain. This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4.; MGRL029 NP_852813.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_852814.2 MGA_0674; contains predicted signal peptidase II cleavage site; similar to proteins encoded by paralogous gene families in other mycoplasmas; MGRL031 NP_852815.1 MGA_0676; similar to COG1525, Micrococcal nuclease (thermonuclease) homologs; cd00175, SNc, Staphylococcal nuclease homologues; contains predicted signal peptidase II cleavage site; MGRL032 NP_852816.2 MGA_0677; similar to MalK [G] COG3839 ABC-type sugar transport systems, ATPase components; pfam00005, ABC_tran, ABC transporter; PRK11650 glycerol-3-phosphate transporter ATP-binding subunit; PS00211; MGRL033 NP_852817.2 MGA_0680; UgpA [G] COG1175 ABC-type sugar transport systems permease component; PRK10561, glycerol-3-phosphate transporter subunit; MGRL034 NP_852818.1 MGA_0682; UgpE [G] COG0395 ABC-type sugar transport system, permease component; MGRL035 NP_852819.2 MGA_0683; [R] COG0618 Exopolyphosphatase-related proteins; pfam01368, DHH, DHH family includes proteins predicted to have phosphoesterase function, including the single stranded DNA exonuclease recJ; pfam02272, DHHA1 (DHH-associated) domain; MGRL036 NP_852820.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_852821.1 MGA_0687; PstS [P] COG0226 ABC-type phosphate transport system; prokaryotic lipoprotein signal PS00013; PDOC00013; PS00890; MGRL038 NP_852822.2 MGA_0689; PtsC [P] COG0573 ABC-type phosphate transport system, permease component; PS00890; MGRL039 NP_852823.2 MGA_0693; PstB [P] COG1117 ABC-type phosphate transport system ATPase component; PS00211; MGRL040 NP_852824.2 MGA_0694; PhoU [P] COG0704 Phosphate uptake regulator; PRK11115, transcriptional regulator PhoU; pfam01895, PhoU, PhoU family. This family contains phosphated regulatory proteins including PhoU; MGRL041 NP_852825.1 Catalyzes the rate-limiting step in dNTP synthesis NP_852826.2 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF NP_852827.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_852828.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_852829.2 MGA_0701; dihydrofolate reductase/deoxycytidylate deaminase COG0262 and COG2131; cd00209, DHFR, Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor, an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-methylenetetrahydrofolate which is then utilized by thymidylate synthase; cd01286, deoxycytidylate_deaminase, Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase; MGRL046 NP_852830.2 MGA_0702; MGRL047 NP_852831.1 MGA_0704; contains 7 predicted transmembrane helices; MGRL049 NP_852832.2 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_852833.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_852834.2 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_852835.2 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_852836.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_852837.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_852838.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_852839.2 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_852840.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_852841.2 one of the stabilizing components for the large ribosomal subunit NP_852842.1 MGA_0725; RpsQ [J] COG0186 Ribosomal protein S17; MGRL060 NP_852843.2 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_852844.1 MGA_0723; RplX [J] COG0198 Ribosomal protein L24; MGRL062 NP_852845.2 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_852846.2 MGA_0732; RpsN [J] COG0199 Ribosomal protein S14; MGRL064 NP_852847.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_852848.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_852849.1 binds 5S rRNA along with protein L5 and L25 NP_852850.2 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_852851.2 late assembly protein NP_852852.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_852853.2 MGA_0743; Adk [F] COG0563 Adenylate kinase and related kinases; MGRL071 NP_852854.1 MGA_0745; Map [J] COG0024 Methionine aminopeptidase; MGRL072 NP_852855.1 MGA_0746; Mdh [C] COG0039 Malate/lactate dehydrogenase; MGRL073 NP_852856.2 MGA_0754; similar to large compositionally biased proteins from related mycoplasmas and other organisms; contains a predicted signal peptidase I cleavage site; N-rich protein; MGRL076 NP_852857.2 MGA_0753; LysU [J] COG1190 Lysyl-tRNA synthetase (class II); pfam00152, tRNA-synt_2, tRNA synthetases class II (D, K and N); PRK00484; MGRL077 NP_852858.1 MGA_1324d; contains N-terminal and potential C-terminal DnaJ domains, [O] COG0484 DnaJ molecular chaperones; pfam00226, DnaJ, DnaJ domain; PS50076; MGRL078 NP_852859.1 MGA_0758; N-terminal similarity to pfam10615, DUF2470; [P] COG0748 Putative heme iron utilization protein HugZ; MGRL079 NP_852860.1 MGA_0760; contains 8 predicted transmembrane domains; MGRL080 NP_852861.1 MGA_0762; MGRL081 NP_852862.2 MGA_0763; HPr protein kinase phosphoryltransferase; [G] COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria); pfam05524, PEP-utilisers_N; pfam00391, PEP-utilizers, PEP-utilising enzyme, mobile domain; pfam02896, PEP-utilizers_C; MGRL082 NP_852863.2 MGA_0765; similarity to PRK08295, RNA polymerase factor sigma-70; COG1191, FliA, DNA-directed RNA polymerase specialized sigma subunit; MGRL083 NP_852864.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_852865.2 MGA_0768; [R] COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily; MGRL085 NP_852866.2 MGA_0771; FtsK [D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; pfam01580, FtsK_SpoIIIE, FtsK/SpoIIIE family; MGRL086 NP_852867.1 MGA_0774; [O] COG3118 Thioredoxin domain-containing protein; pfam00085, Thioredoxin; MGRL087 NP_852868.1 MGA_0777; similar to large proteins (MG_422, MPN620) encoded by related mycoplasmas and to large compositionally-biased proteins; KN-rich protein; MGRL088 NP_852869.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_852870.3 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_852871.2 MGA_0783; PyrH [F] COG0528 Uridylate kinase; MGRL091 NP_852872.2 MGA_0784; Frr [J] COG0233 Ribosome recycling factor; MGRL092 NP_852873.2 MGA_0785; CdsA [I] COG0575 CDP-diglyceride synthetase; MGRL093 NP_852874.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate NP_852875.2 MGA_0789; [M] COG0750 predicted membrane-associated Zn-dependent proteases 1; pfam02163, Peptidase_M50, Peptidase family M50; PS00142 Neutral zinc metallopeptidases zinc-binding region signature; MGRL095 NP_852876.2 MGA_0791; PolC [L] COG2176 DNA polymerase III, alpha subunit (gram-positive type); pfam07733, pfam00929, pfam02811; MGRL096 NP_852877.2 MGA_0793; COG1112, Superfamily I DNA and RNA helicases and helicase subunits; MGRL097 NP_852878.1 MGA_0797; Mgal gene family 17 protein, contains 9 predicted transmembrane helices; MGRL098 NP_852879.1 MGA_0798; AprE [O] COG1404 Subtilisin-like serine proteases; PF00082 Subtilase family; PS00138 Serine proteases subtilase family serine active site; PS50321 Asparagine-rich region; contains predicted signal peptidase I cleavage site; MGRL099 NP_852880.2 MGA_0800; Mgal gene family 17 protein, contains 9 predicted transmembrane helices; MGRL100 NP_852881.2 MGA_0801; potential C-terminal fragment of subtilisin-like protease; [O] COG1404 Subtilisin-like serine proteases AprE; pfam00082, Peptidase_S8, Subtilase family; PS00138 Serine proteases subtilase family serine active site; MGRL101a NP_852882.2 MGA_0802; potential N-terminal fragment of subtilisin-like protease; contains predicted signal peptidase I cleavage site; MGRL101b NP_852884.2 MGA_0805; putative ABC transport protein; [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component NosY; pfam01061, ABC2_membrane, ABC-2 type transporter; contains 6 predicted transmembrane helices; MGRL103 NP_852885.2 MGA_0806; similar to CcmA [V] COG1131 ABC-type multidrug transport system, ATPase component; MGRL104 NP_852886.1 MGA_0808; similar to hypothetical proteins and lipoproteins from other mollicutes; contains predicted signal peptidase II cleavage site; MGRL105 NP_852887.2 MGA_0809; similar to hypothetical proteins and lipoproteins from other mollicutes; contains predicted signal peptidase II cleavage site; MGRL106 NP_852888.2 MGA_0810; similar to hypothetical proteins and lipoproteins from other mollicutes; contains predicted signal peptidase I cleavage site; MGRL107 NP_852889.1 MGA_0811; contains predicted signal peptidase II cleavage site; MGRL108 NP_852890.2 MGA_0812; contains predicted signal peptidase I cleavage site; MGRL109 NP_852892.2 MGA_0815; AprE [O] COG1404 Subtilisin-like serine proteases; pfam00082, Peptidase_S8, Subtilase family; PS00138 Serine proteases subtilase family serine active site; MGRL111 NP_852893.2 MGA_0816; Mgal gene family 17 protein; contains 9 predicted transmembrane helices; MGRL112 YP_003573362.1 MGA_0817a; potential N-terminal fragment of Mgal gene family 17 protein; MGRL113a NP_852894.2 MGA_0817b; potential C-terminal fragment of Mgal gene family 17 protein; contains 8 predicted transmembrane helices; MGRL113b NP_852895.2 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_852896.1 MGA_0820; similarity to [K] COG2740 Predicted nucleic-acid-binding protein implicated in transcription termination; pfam04296, DUF448, Protein of unknown function; cd00279, YlxR, Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; MGRL115 NP_852897.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_852898.2 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_003573363.1 MGA_0829b; potential C-terminal fragment of gene family 11 protein; MGRL119a NP_852899.1 MGA_0829a; potential N-terminal fragment of gene family 11 protein; prokaryotic lipoprotein signal PS00013; MGRL119b NP_852900.2 MGA_0830; MGRL120 NP_852901.2 MGA_0831; TruB [J] COG0130 Pseudouridine synthase; MGRL121 NP_852902.1 MGA_0832; N-terminal RibF domain, COG0196 FAD synthase, C-terminal TrmU domain, COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase; pfam06574, FAD_syn, FAD synthetase. This family corresponds to the N terminal domain of the bifunctional enzyme riboflavin; MGRL122 NP_852903.1 MGA_0833; ACH1 [C] COG0427 Acetyl-CoA hydrolase; MGRL123 NP_852904.2 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_852905.1 MGA_0836; [L] similar to COG0816 predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis); MGRL125 NP_852906.1 MGA_0837; SAM-dependent methyltransferases COG0500; MGRL126 NP_852907.1 MGA_0838; [O] COG0826 Collagenase and related proteases; pfam01136, Peptidase_U32, Peptidase family U32; MGRL127 NP_852908.2 MGA_0839; [O] COG0826 Collagenase and related proteases; pfam01136, Peptidase_U32, Peptidase family U32; MGRL128 NP_852909.2 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_852910.2 MGA_0843; MGRL130 NP_852911.2 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth NP_852912.2 MGA_0847; MGRL132 NP_852913.1 MGA_0848; EbgC [G] COG2731 Beta-galactosidase, beta subunit; pfam04074, DUF386, Domain of unknown function (DUF386). This family consists of conserved hypothetical proteins, typically about 150 amino acids in length, with no known function; MGRL133 NP_852914.1 MGA_0849; contains 2 predicted transmembrane domains; MGRL134 NP_852915.2 MGA_0851; COG0217, Uncharacterized conserved protein; pfam01709, DUF28, Domain of unknown function DUF28; MGRL135 YP_003573364.1 MGA_1335; contains 2 predicted transmembrane helices; MGRL142 NP_852916.2 MGA_0855; PtsG [G] COG1263 Phosphotransferase system IIC components glucose/maltose/N-acetylglucosamine-specific; PRK10255, fused N-acetyl glucosamine specific PTS enzyme IIC, IIB , and IIA components; MGRL143 NP_852917.2 MGA_0860; PutA [C] COG1012 NAD-dependent aldehyde dehydrogenases; potential translational start at position 173939 but likely translational start at 174002 by homology; MGRL144 NP_852918.2 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_852919.2 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_852920.2 MGA_0864; HemK [J] COG2890 Methylase of polypeptide chain release factors; pfam05175, MTS, Methyltransferase small domain; MGRL147 NP_852921.1 MGA_0865; similar to SUA5 [J] COG0009 predicted translation factor (SUA5); pfam01300, Sua5_yciO_yrdC, yrdC domain. This domain has been shown to preferentially bind to dsRNA; PRK10634, predicted ribosome maturation factor; MGRL148 NP_852922.2 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity NP_852923.1 MGA_0867; contains 2 predicted transmembrane domains; MGRL150 NP_852924.2 MGA_0868; PrfA [R] COG3331 Penicillin-binding protein-related factor A predicted recombinase; pfam03838, Recombination protein U; PRK02234, recU, Holliday junction-specific endonuclease; MGRL151 NP_852925.1 MGA_0869; [L] COG0776 Bacterial nucleoid DNA-binding protein; cd00591, HU_IHF, Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-order nucleoprotein complex assembly; smart00411, BHL, bacterial (prokaryotic) histone like domain; MGRL152 NP_852926.2 MGA_0870; pfam09188, DUF1951, Domain of unknown function (DUF1951). Member of this family of Mycoplasma hypothetical proteins adopt a helical structure, with a buried central helix; MGRL153 NP_852927.2 MGA_0871; contains 2 predicted transmembrane domains; MGRL154 NP_852928.3 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_852929.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_852930.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_852931.2 MGA_0875; contains 1 predicted transmembrane domain; MGRL158 NP_852932.2 MGA_0877; DnaJ [O] COG0484 Molecular chaperones (contain C-terminal Zn finger domain); MGRL159 NP_852933.1 MGA_0878; PS00013 prokaryotic lipoprotein signal; paralog of MGA_0887; MGRL160 NP_852934.2 MGA_0879; contains 12 predicted transmembrane domains; paralog of MGA_0889/0892; similarity to NorM COG0534 Na+-driven multidrug efflux pump; PRK09575 multidrug efflux pump VmrA; MGRL161 NP_852935.2 MGA_0884; C-terminal fragment of MetG [J] COG0143 Methionyl-tRNA synthetase; MGRL162 YP_003573365.1 MGA_0885; C-terminal fragment of DnaJ-like protein; [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; pfam00684, DnaJ_CXXCXGXG, DnaJ central domain; MGRL163a YP_003573366.1 MGA_0886; N-terminal fragment of DnaJ-like protein; [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; pfam00226, DnaJ, DnaJ domain.; MGRL163b NP_852936.1 MGA_0887; PS00013 prokaryotic lipoprotein signal; paralog of MGA_0878; Serine-rich protein; MGRL164 NP_852937.1 MGA_0889; potential N-terminal fragment paralog of MGA_0879; similar to NorM [V] COG0534 Na+-driven multidrug efflux pump; predicted to contain 8 transmembrane domains; MGRL165a NP_852938.2 MGA_0892; potential C-terminal fragment paralog of MGA_0879; predicted to contain 2 transmembrane domains; MGRL165b NP_852939.1 MGA_0893; MetG [J] COG0143 Methionyl-tRNA synthetase; MGRL166 NP_852940.2 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_852941.2 MGA_0900; Cmk [F] COG0283 Cytidylate kinase; MGRL168 NP_852942.2 MGA_0901; similarity to M. pneumoniae MPN477; MGRL169 NP_852943.2 MGA_0902; [R] COG0693 Putative intracellular protease/amidase; similar to PF01965 DJ-1/PfpI family; cd03135, GATase1_DJ-1, Type 1 glutamine amidotransferase (GATase1)-like domain; MGRL170 NP_852944.2 MGA_0906; [O] COG1404, AprE, Subtilisin-like serine proteases; pfam00082, Peptidase_S8, Subtilase family; PS00138; Serine proteases, subtilase family serine, active site; MGRL180 NP_852945.1 MGA_0907; Mgal gene family 17 protein, predicted to contain 8 transmembrane helices; MGRL181 NP_852946.2 MGA_0908; potential N-terminal fragment of Mgal gene family 17 protein, predicted to contain 4 transmembrane helices; MGRL183a NP_852947.2 MGA_0910; [L] COG3328 Transposase and inactivated derivatives; MGA_t04; MGRL184 NP_852948.2 MGA_0911; potential C-terminal fragment of Mgal gene family 17 protein; MGRL183b NP_852949.2 MGA_0913; PS00013 prokaryotic lipoprotein signal; similarity to M. pneumoniae MPN_523; MGRL185 NP_852950.1 MGA_0914; miaA [J] COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase; MGRL186 NP_852951.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_852952.1 MGA_0917; p115-like, similar to Smc [D], COG1196 Chromosome segregation ATPases; pfam02463, SMC_N, RecF/RecN/SMC N terminal domain; pfam06470, SMC_hinge, SMC proteins Flexible Hinge Domain. This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer; MGRL188 NP_852953.2 MGA_0919; FtsY [N] COG0552 signal recognition particle GTPase PS00017; pfam00448, SRP54, SRP54-type protein, GTPase domain, and pfam02881, SRP54_N, SRP54-type protein, helical bundle domain; MGRL189 NP_852954.2 MGA_0922; [S] COG2739 Uncharacterized protein conserved in bacteria; similar to pfam04297, UPF0122, Putative helix-turn-helix protein, YlxM / p13-like; MGRL190 NP_852955.1 MGA_0923; similarity to C-terminal domain of PRK01490, tig, trigger factor; similarity to COG0544, Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); MGRL191 NP_852956.2 MGA_0924; homologue of Mycoplasma pneumoniae MPN554 ssDNA-binding protein gi:1673959; MGRL192 NP_852957.1 MGA_0925; ThrS [J] COG0441 Threonyl-tRNA synthetase; MGRL193 NP_852958.2 MGA_0927; similar to proteins encoded in related mycoplasmas, M. pneumoniae MPN552 and M. genitalium MG374; MGRL194 NP_852959.2 MGA_0928; high molecular weight 3 (HMW3)-like protein (Hlp3), homolog of M. pneumoniae cytadherence-associated protein HMW3; MGRL195 NP_852960.2 MGA_0931; similar to [M] COG0510, CotS, Predicted choline kinase involved in LPS biosynthesis; pfam01636 Phosphotransferase enzyme family; MGRL196 NP_852961.2 MGA_0932; adhesin protein Mgc2/P32, similar to M. pneumoniae 30K adhesin protein; contains predicted signal peptidase I cleavage site and 1 N-terminal transmembrane helix; MGRL197 NP_852962.2 MGA_0934; Mycoplasma gallisepticum adherence protein A (GapA); homolog of M. pneumoniae adhesin P1; contains predicted signal peptidase I cleavage site and 1 C-terminal transmembrane helix; Mgal gene family 3 protein; MGRL198 NP_852963.1 MGA_0939; cytadherence related molecule A (CrmA); similar to M. pneumoniae C/B cytadherence-associated proteins encoded by MPN142/orf6 and to M.genitalium P110; contains predicted signal peptidase I cleavage site and 1 C-terminal transmembrane helix; Mgal gene family 3 protein; MGRL199 NP_852964.1 MGA_0943; predicted cytadherence related protein B (CrmB); similarity with M. pneumoniae P1 adhesin; Mgal gene family 3 protein; MGRL200 NP_852965.2 MGA_0945; predicted cytadherence related protein C (CrmC); similar to M. pneumoniae C/B cytadherence-associated proteins encoded by MPN142/orf6 and to M.genitalium P110; Mgal gene family 3 protein, contains 2 predicted transmembrane helices; MGRL201 NP_852966.2 MGA_0947; HisS [J] COG0124 Histidyl-tRNA synthetase; MGRL202 NP_852967.1 MGA_0948; AspS [J] COG0173 Aspartyl-tRNA synthetase; MGRL203 NP_852968.2 MGA_0950; SpoT [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; PRK11092, bifunctional (p)ppGpp synthetase II/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; MGRL204 NP_852969.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_852970.2 MGA_0954; contains predicted signal peptidase I cleavage site and 11 transmembrane helices; MGRL206 NP_852971.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_852972.1 MGA_0956; contains 7 predicted transmembrane helices; MGRL208 NP_852973.1 MGA_0957; similar to M. pneumoniae MPN454; contains 2 predicted transmembrane helices; MGRL209 NP_852974.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_852975.1 MGA_0963; similar to PotE [E] COG0531 Amino acid transporters; pfam00324, AA_permease, Amino acid permease; MGRL216 NP_852976.2 MGA_0965; DNA protection during starvation protein, neutrophil activating protein A, bacterioferritin; [P] COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); cd01043, DPS, DPS (DNA Protecting protein under Starved conditions) domain is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins; MGRL217 NP_852977.1 MGA_0966; vlhA.4.01 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.2 1.1; MGRL218 NP_852978.2 MGA_0967; vlhA.4.02 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.7; MGRL219 YP_003573367.1 MGA_0968; vlhA.4.03a potential N-terminal fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); MGRL220a YP_003573368.1 MGA_0970; vlhA.4.03b potential C-terminal fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL220b NP_852979.1 MGA_0972; vlhA.4.04 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to VlhA-like protein 9.2 1.4 1.3; MGRL221 NP_852980.2 MGA_0973; vlhA.4.05 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA protein 9.2 1.4 1.3; MGRL222 NP_852981.1 MGA_0974; vlhA.4.06 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.4 1.3; MGRL223 NP_852982.1 MGA_0977; vlhA.4.07 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.2 1.1; MGRL224 YP_003573369.1 MGA_1336; vlhA.4.07.1 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL225 YP_003573370.1 MGA_1337; vlhA.4.07.2a potential fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); MGRL226a YP_003573371.1 MGA_1338; vlhA.4.07.2b potential fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL226b YP_003573372.1 MGA_1339; vlhA.4.07.3 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL227 YP_003573373.1 MGA_1340; vlhA.4.07.4 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL228 YP_003573374.1 MGA_1341; vlhA.4.07.5 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL229 YP_003573375.1 MGA_1342; vlhA.4.07.6 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL230 NP_852983.1 MGA_0979; vlhA.4.08 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.3 1.2 1.4; MGRL231 NP_852984.1 MGA_0981; vlhA.4.09 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.3 1.4; MGRL232 NP_852985.1 MGA_0984; vlhA.4.10 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.7; MGRL233 NP_852986.1 MGA_0986; vlhA.4.11 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.3 1.4; MGRL234 NP_852987.1 MGA_0987; vlhA.4.12 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.4 1.3; MGRL235 YP_003573376.1 MGA_1343; MGRL236 NP_852988.1 MGA_0993; conserved hypothetical lipoprotein, Mgal gene family 11; PS00013 prokaryotic lipoprotein signal; MGRL237 NP_852989.1 MGA_0994; similar to Dut [F] COG0756 dUTPase; pfam00692, dUTPase; MGRL238 NP_852990.2 MGA_0995; [O] COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; domain similar to pfam00814, Peptidase_M22, Glycoprotease family. The Peptidase M22 proteins are part of the HSP70-actin superfamily; MGRL239 NP_852991.2 MGA_0996; RluA [J] COG0564 Pseudouridylate synthases 23S RNA-specific; MGRL240 NP_852992.1 MGA_0997; LspA [N] COG0597 lipoprotein signal peptidase; MGRL241 NP_852993.1 MGA_0998; [R] COG0693 Putative intracellular protease/amidase; similar to pfam01965 DJ-1/PfpI family; cd03135, GATase1_DJ-1, Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; MGRL242 YP_003573377.1 MGA_1359; likely fragment of restriction modification methylase; MGRL243 YP_003573378.1 MGA_1344; likely gene fragment; similarity to central regions of restriction endonucleases AAC45970.1, AF300473_1; MGRL244 NP_852994.1 MGA_0999; MhpC [R] COG1075 predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold; pfam00561, Abhydrolase_1, alpha/beta hydrolase fold; Mgal gene family 12; MGRL245 NP_852995.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_852996.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_852997.2 MGA_1010; contains predicted signal peptidase I cleavage site; MGRL248 NP_852998.2 MGA_1011; contains 1 predicted transmembrane helix; MGRL249 NP_852999.1 MGA_1014; potential N-terminal fragment of unique hypothetical protein intact in other M. gallisepticum strains; contains 3 predicted transmembrane helices; MGRL250a YP_003573379.1 MGA_1345; potential C-terminal fragment of unique hypothetical protein intact in other M. gallisepticum strains; MGRL250b NP_853000.1 MGA_1017; high affinity transport protein A (HatA); pfam06646, Mycoplasma_p37, High affinity transport system protein p37; contains predicted signal peptidase I cleavage site; MGRL252 NP_853001.1 MGA_1018; high affinity transport protein B (HatB); [P] COG3638 ABC-type phosphate/phosphonate transport system, ATPase component; pfam00005, ABC_tran, ABC transporter; cd03256, ABC_PhnC_transporter, ABC-type phosphate/phosphonate transport system; MGRL253 NP_853002.1 MGA_1019; high affinity transport protein C (HatC); [P] COG3639 ABC-type phosphate/phosphonate transport system, permease component; contains 11 predicted tansmembrane helices; MGRL254 NP_853003.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_853004.2 MGA_1027; similar to M. pneumoniae MPN403; potential translational start at position 326915 but likely translational start at 327005 by homology and predicted by Prodigal; MGRL256 NP_853005.1 MGA_1029; similar to M. pneumoniae MPN404; MGRL257 NP_853006.2 MGA_1031; similar to M. pneumoniae MPN405; contains a predicted signal peptidase I cleavage site; MGRL258 NP_853007.2 carries the fatty acid chain in fatty acid biosynthesis NP_853008.2 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_853009.2 MGA_1034; similar to [S] COG1307 Uncharacterized protein conserved in bacteria; pfam02645, DegV, Uncharacterised protein, DegV family COG1307. The structure of this protein revealed a bound fatty-acid molecule in a pocket between the two protein domains, suggesting a molecular function of fatty-acid binding and potential role in the cellular fatty acid transport or metabolism functions; potential translational start at position 330791 but likely translational start at 330839 by homology and predicted by Prodigal; MGRL262 NP_853010.2 MGA_1036; ARC1 [R] COG0073 EMAP domain; pfam01588, tRNA_bind, Putative tRNA binding domain; cd02796, tRNA_bind_bactPheRS, tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain; MGRL263 NP_853011.2 MGA_1037; similarity to COG0534 Na+-driven multidrug efflux pump; contains 12 predicted transmembrane helices; potential translational start at position 332294 but likely translational start at 332226 by homology and predicted by Prodigal; MGRL264 NP_853012.2 MGA_1046; Mgal gene family 17 protein; contains 8 predicted transmembrane helices; MGRL268 NP_853013.2 MGA_1047; MGRL269 NP_853014.1 catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand; in the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria. NP_853015.2 MGA_1052; Exo [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI); pfam02739, 5_3_exonuc_N, 5'-3' exonuclease, N-terminal resolvase-like domain; pfam01367, 5_3_exonuc, 5'-3' exonuclease, C-terminal SAM fold; MGRL271 NP_853016.2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases NP_853017.2 MGA_1054n; CoaE [H] COG0237 Dephospho-CoA kinase; MGRL273 NP_853018.2 MGA_1058; similarity to COG3611, DnaB, Replication initiation/membrane attachment protein; similarity to pfam07261, DnaB_2; MGRL274 NP_853019.1 MGA_1059; MGRL275 NP_853020.2 MGA_1061; MgtA [P] COG0474 Cation transport ATPases; pfam00122, E1-E2_ATPase, E1-E2 ATPase; MGRL276 NP_853021.2 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_853022.2 MGA_1067; PgsA [I] COG0558 Phosphatidylglycerophosphate synthase; contains 5 predicted transmembrane helices; MGRL278 NP_853023.1 MGA_1068; MGRL279 NP_853024.1 MGA_1069; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT; ispD [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; pfam01128, IspD, Uncharacterized protein family UPF0007; MGRL280 NP_853025.2 MGA_1070; MGRL281 NP_853026.1 MGA_1071; contains 1 predicted N-terminal transmembrane helix; MGRL282 NP_853027.2 MGA_1073; conserved hypothetical liporprotein, Mgal gene family 11; PS00013 prokaryotic lipoprotein signal; MGRL283 NP_853028.1 MGA_1076; malK [G] COG3839 ABC-type sugar transport systems, ATPase components; putative ugpC, glycerol-3-phosphate transporter ATP-binding subunit; MGRL284 NP_853029.1 MGA_1077; putative sn-glycerol-3-phosphate transport system permease protein; UgpA [G] COG1175 ABC-type sugar transport systems, permease component; PS00890; MGRL285 NP_853030.1 MGA_1078; putative sn-glycerol-3-phosphate transport system permease; UgpE [G] COG0395 ABC-type sugar transport system, permease component; MGRL286 NP_853031.2 MGA_1079; similar to homologues in M. synoviae; contains predicted signal peptidase II cleavage site; MGRL287 NP_853032.2 MGA_1328d; potential fragment of [F] COG0274 Deoxyribose-phosphate aldolase; MGRL289 NP_853033.1 MGA_1081; [L] COG3328 Transposase and inactivated derivatives; MGA_t06; MGRL290 NP_853034.1 MGA_1083; similar to Cof [R] COG0561 Predicted hydrolases of the HAD superfamily; pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase; contains N-terminus similar to licA ABC transporter component gene fragments present in strain F; MGRL291 NP_853035.2 MGA_1085; highly similar to homolgs in M. synoviae; contains predicted signal peptidase I cleavage site; MGRL292 NP_853036.2 MGA_1087; highly similar to homolgs in M. synoviae; contains predicted signal peptidase I cleavage site; MGRL293 NP_853037.1 MGA_1088; potential N-terminal fragment of ABC-type transport system ATPase component; MGRL294; MGRL294a NP_853038.2 MGA_1089; potential C-terminal fragment of ABC-type transport system ATPase component; pfam02687, FtsX, Predicted permease; similar to domain of COG3127, Predicted ABC-type transport system permease component; PS00890; contains predicted signal peptidase I cleavage site; MGRL294b NP_853039.2 MGA_1091; putative signal peptidase I (SPase I) (leader peptidase I); similar to LepB [N] COG0681 signal peptidase I; pfam00717, Peptidase_S24, Peptidase S24-like; PRK10861, leader peptidase (signal peptidase I); MGRL295 NP_853040.1 MGA_1092; C-terminal fragment of FusA [J] COG0480 Translation elongation and release factors (GTPases); pfam00679, EFG_C, Elongation factor G C-terminus; pfam03764, EFG_IV, Elongation factor G, domain IV; MGRL296 NP_853042.2 AS-AR; AsnRS2; similar to asparaginyl-tRNA synthetase but lacking the N-terminal anticodon-binding site; the enzyme from Pyrococcus converts aspartic acid into asparagine NP_853043.2 MGA_1102; contains predicted signal peptidase I cleavage site and 3 transmembrane helices; MGRL299 NP_853044.2 MGA_1103; C-terminal similarity to pfam08242, Methyltransf_12, and pfam08241, Methyltransf_11 methyltransferase domains in predicted intracellular domain; contains 12 predicted transmembrane helices; MGRL300 YP_003573380.1 MGA_1347; potential fragment of predicted transposase-like protein; MGA_t08; MGRL301 NP_853045.2 MGA_1106; N-terminal fragment of predicted transposase; MGA_t09; MGRL302 NP_853046.1 MGA_1107; similarity to [S] COG1322 Predicted nuclease of restriction endonuclease-like fold, RmuC family, and in the C-terminus to pfam02646 RmuC family domain; contains predicted signal peptidase I cleavage site; MGRL303 NP_853047.2 MGA_1108; potential N-terminal fragment of ISMHp1-like transposases in other mycoplasmas but distinct from transposases in M. gallisepticum; MGA_t10a; MGRL304a NP_853048.1 MGA_1109; potential C-terminal fragment of predicted transposase; homologous to C-terminus of transposase-like protein in M. synoviae; [L] COG5421 Transposase; pfam01609 Transposase DDE domain; MGA_t10b; MGRL304b NP_853049.2 MGA_1110; [R] COG0431 Predicted flavoprotein; similar to pfam03358, FMN_red, NADPH-dependent FMN reductase and pfam02525, Flavodoxin_2, Flavodoxin-like fold; MGRL305 NP_853050.1 MGA_1111; MGRL306 NP_853051.2 MGA_1112; potential C-terminal fragment of unique hypothetical protein intact in other M. gallisepticum strains; MGRL307a YP_003573381.1 MGA_1113; potential N-terminal fragment of unique hypothetical protein intact in other M. gallisepticum strains; MGRL307b NP_853052.1 MGA_1115; MGRL308 NP_853053.1 MGA_1116; Cof [R] COG0561 Predicted hydrolases of the HAD superfamily; pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase; MGRL309 NP_853054.1 MGA_1117; potential fragment of CrmB-like protein, similar to predicted cytadherence-related molecule B and to M. pneumoniae P1 adhesin; contains predicted signal peptidase I cleavage site; MGRL310a NP_853055.2 MGA_1119; potential fragment of CrmB-like protein, similar to predicted cytadherence molecule B and to M. pneumoniae P1 adhesin; contains predicted transmembrane helix; MGRL310b NP_853056.2 MGA_1122; contains 6 predicted transmembrane helices;potential translational start sites at positions 396816 and 396735 but likely translational start site at 396720 by homology; MGRL312 NP_853057.2 catalyzes the hydrolysis of pyrophosphate to phosphate NP_853058.1 MGA_1123; [R] COG1451 predicted metal-dependent hydrolase; pfam01863, DUF45, Protein of unknown function DUF45; MGRL314 NP_853059.1 MGA_1125; SufC [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; MGRL315 NP_853060.2 MGA_1127; similar to SufB [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component; pfam01458, UPF0051, Uncharacterized protein family (UPF0051); MGRL316 NP_853061.2 MGA_1128; CsdB [E] COG0520 Selenocysteine lyase; PF00266 Aminotransferase class-V; MGRL317 NP_853062.1 MGA_1129; similar to [C] COG0822 IscU/NifU homologs involved in Fe-S cluster formation; PF01592 NifU-like N terminal domain, These proteins appear to be scaffold proteins for iron-sulfur clusters; MGRL318 NP_853063.1 MGA_1130; similar to SufB [O] COG0719, SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component; pfam01458, UPF0051, Uncharacterized protein family; PRK11814, component of SufBCD complex; MGRL319 NP_853064.1 MGA_1131; CbpA [O] COG2214 Molecular chaperones, DnaJ class; contains 3 predicted C-terminal transmembrane helices; MGRL320 NP_853065.2 MGA_1133; GpsA [C] COG0240 Glycerol 3-phosphate dehydrogenase; MGRL321 NP_853066.1 MGA_1135; C-terminal J domain; similar to a domain of [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; pfam00226 DnaJ domain; MGRL322 NP_853067.2 MGA_1138; CcmA [Q] COG1131 ABC-type multidrug transport system ATPase component; cd03263, ABC_subfamily_A, The ABCA subfamily mediates the transport of a variety of lipid compounds; cd03265, ABC_DrrA, DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin; MGRL323 NP_853068.2 MGA_1140; PS00890; contains 6 predicted transmembrane helices; MGRL324 NP_853069.2 MGA_1142; OsmC [O] COG1764 predicted redox protein regulator of disulfide bond formation; PF02566 OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress-induced protein found in E. Coli; MGRL325 NP_853070.1 MGA_1143; Ffh [N] COG0541 signal recognition particle GTPase; MGRL326 NP_853071.2 MGA_1144; TyrS [J] COG0162 Tyrosyl-tRNA synthetase; MGRL327 NP_853072.2 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_853074.2 MGA_1153; [O] COG4870 Cysteine protease; cd02619, Peptidase_C1, C1 Peptidase family (MEROPS database nomenclature); pfam00112, Peptidase_C1, Papain family cysteine protease; MGRL331 NP_853075.2 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_853076.2 MGA_1155; RpsI [J] COG0103 Ribosomal protein S9; MGRL333 NP_853077.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis NP_853078.2 MGA_1159; Upp [F] COG0035 Uracil phosphoribosyltransferase; MGRL335 NP_853079.2 MGA_1161; pfam01727, DUF30, Domain of unknown function DUF30. This family of domains are found in several putative lipoproteins from mycoplasmas. The domain is also found in isolation in some proteins; pfam01732, DUF31, Domain of unknown function DUF31. This domain has no known function. It is found in various hypothetical proteins and putative lipoproteins from mycoplasmas; MGRL336 NP_853081.1 MGA_1163; MGRL337 NP_853082.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_853083.1 MGA_1167; AtpE [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K; MGRL339 NP_853084.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. NP_853085.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_853086.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_853087.1 MGA_1174; AtpG [C] COG0224 F0F1-type ATP synthase gamma subunit; MGRL343 NP_853088.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_853089.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_853090.2 MGA_1180; [S] COG4866 Uncharacterized conserved protein; no obvious homologs in M. pneumoniae or M. genitalium; MGRL346 NP_853091.1 MGA_1182; similar to M. penetrans MYPE4910; MGRL347 NP_853092.2 MGA_1184; similar to pfam02645, DegV, Uncharacterised protein, DegV family [S] COG1307; MGRL350 NP_853093.1 MGA_1186; gapdh; GapA [G] COG0057 glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; MGRL351 NP_853094.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_853095.1 MGA_1188; PotE [E] COG0531 Amino acid transporters; pfam00324, AA_permease, Amino acid permease, PS50286 AROMATIC_AA_PERM_2; MGRL353 NP_853096.2 MGA_1189; similar to proteins in M. pneumoniae and M. genitalium; MGRL354 NP_853097.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_853098.1 MGA_1191; MGRL357 NP_853099.2 MGA_1194; [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase; MGRL358 NP_853100.2 MGA_1195; CspR [J] COG0219 predicted rRNA methylase (SpoU class); pfam00588, SpoU_methylase, SpoU rRNA Methylase family; MGRL359 NP_853101.2 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_003573382.1 MGA_1197; fldA [C] COG0716 Flavodoxins; pfam00258, Flavodoxin_1, Flavodoxin; MGRL361 NP_853102.2 MGA_1199; Pneumoniae-like protein A (plpA), fibronectin-binding; similarity to large, compositionally biased proteins including M. pneumoniae cytadherence-associated proteins HMW2, P65, HMW3; repetitive, QNE-rich protein; MGRL362 NP_853103.1 MGA_1203; high molecular weight 2 (HMW2)-like protein (Hlp2), homolog of M. pneumoniae cytadherence-associated protein HMW2; MGRL363 NP_853104.2 MGA_1208; similarity to large, compositionally biased proteins including MGA_1203 hlp2 and M. pneumoniae cytadherence-associated proteins HMW2 and P41 in N-terminal domains; QKNE-rich protein; MGRL364 NP_853105.2 MGA_1210; MGRL365 NP_853106.2 MGA_1211; similarity to large, compositionally biased proteins including M. pneumoniae cytadherence-associated proteins HMW2, HMW1, P200; KEDQ-rich; MGRL366 NP_853108.2 MGA_1215; MGRL367 NP_853109.2 MGA_1216; MGRL368 NP_853110.2 MGA_1218; contains 1 predicted transmembrane helix; MGRL369 NP_853111.2 MGA_1220; ArcA [E] COG2235 Arginine deiminase; MGRL370 NP_853112.1 MGA_1221; TrxB [O] COG0492 Thioredoxin reductase; pfam07992, Pyr_redox_2, Pyridine nucleotide-disulphide oxidoreductase; MGRL371 NP_853113.1 MGA_1222; similarity to large, compositionally biased proteins including MGA_1208, MGA_1203 hlp2, and M. pneumoniae cytadherence-associated protein HMW2; KE-rich protein; MGRL372 NP_853114.2 MGA_1224; similarity to large, compositionally biased proteins including MGA_1208, MGA_1203 hlp2, and M. pneumoniae cytadherence-associated protein HMW2; DKQ-rich protein; MGRL374 NP_853115.1 MGA_1227; MhpC [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); pfam00561, Abhydrolase_1, alpha/beta hydrolase fold; Mgal gene family 12; MGRL375 NP_853116.1 MGA_1228; similar to M. pneumoniae MPN119 J-domain protein containing domains present in mycoplasma tip organelle proteins (TopJ), including enriched in aromatic and glycine residues (EAGR) box and acidic/proline rich (APR) domains; [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; PF01556 DnaJ domain; PF00226; PS50076, dnaJ domain profile; PS50313, Glutamic acid-rich region; MGRL376 NP_853117.1 MGA_1232; [O] COG0576 Molecular chaperone GrpE (heat shock protein); pfam01025, GrpE; cd00446, GrpE, GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases; MGRL377 NP_853118.2 MGA_1233; vlhA5.01a potential N-terminal fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); MGRL378a YP_003573383.1 MGA_1234; vlhA5.01b potential fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL378b YP_003573384.1 MGA_1237; vlhA5.01c potential fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL378c NP_853119.1 MGA_1238; vlhA.5.02 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; vlhA.5.02 lacks vlhA signature motifs (GAA repeat seq. 5' start and conserved seq. flanking start); MGRL379 NP_853120.1 MGA_1239; vlhA.5.03 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.4 9.2; MGRL380 NP_853121.1 MGA_1243; vlhA.5.04 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.1 1.2; MGRL381 NP_853122.1 MGA_1245; vlhA.5.05 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.2; MGRL382 NP_853123.1 MGA_1246; vlhA.5.06 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.3 1.4; MGRL383 NP_853124.1 MGA_1249; vlhA.5.07 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.4 1.3; MGRL384 NP_853125.1 MGA_1250; vlhA.5.08 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.2 1.1; MGRL385 NP_853126.1 MGA_1251; vlhA.5.09 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 9.2 1.4 1.3; MGRL386 NP_853127.1 MGA_1253; vlhA.5.10a variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.3 1.4; MGRL387a YP_003573385.1 MGA_1348; vlhA.5.10b variably expressed lipoprotein and hemagglutinin (VlhA) family protein fragment (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL387b NP_853128.1 MGA_1255; vlhA.5.11 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.3 1.4; MGRL388 NP_853129.1 MGA_1257; vlhA.5.12 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.5 1.4; MGRL389 NP_853130.2 MGA_1260; potential C-terminal fragment; similar to C-terminus of RnhC [L] COG1039 Ribonuclease HIII; MGRL390 NP_853131.1 MGA_1261; VlhA.5.13 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; PS00013 prokaryotic lipoprotein signal; MGRL391 NP_853132.1 MGA_1263; beta-pgm [R] COG0637 predicted phosphatase/phosphohexomutase; PRK10826, predicted hydrolase; MGRL392 NP_853133.2 MGA_1265; potential maltose/trehalose hydrolase or phosphorylase C-terminal fragment, intact gene present in M. gallisepticum strain F; maltose phosphorylase function inferred through metabolic pathway analysis; Glycosyl hydrolase-domain protein similar to central and C-terminal regions of glycosyl hydrolase family proteins; similar to ATH1 [G] COG1554 Trehalose and maltose hydrolases (possible phosphorylases); pfam03632, Glyco_hydro_65m, Glycosyl hydrolase family 65 central catalytic domain; pfam03633, Glyco_hydro_65C, Glycosyl hydrolase family 65, C-terminal domain; MGRL393 YP_003573386.1 MGA_1349; potential N-terminal fragment of protein intact in M. gallisepticum strain F; MGRL394 YP_003573387.1 MGA_1350b; potential C-terminal fragment of protein intact in M. gallisepticum strain F; MGRL395a YP_003573388.1 MGA_1350a; potential N-terminal fragment of protein intact in M. gallisepticum strain F; MGRL395b NP_853134.2 MGA_1267; PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; COG1154, Dxs, Deoxyxylulose-5-phosphate synthase; MGRL396 NP_853136.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons NP_853137.3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_853138.2 MGA_1271; COG2739, Uncharacterized protein conserved in bacteria; pfam04297, UPF0122, Putative helix-turn-helix protein, YlxM / p13 like. Members of this family are predicted to contain a helix-turn-helix motif, for example residues 37-55 in Mycoplasma mycoides p13. Genes encoding family members are often part of operons that encode components of the SRP pathway, and this protein may regulate the expression of an operon related to the SRP pathway; MGRL399 NP_853139.2 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_853140.2 MGA_1273; RpmI [J] COG0291 Ribosomal protein L35; MGRL401 NP_853141.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_853142.2 MGA_1275; similar to COG4508, Dimeric dUTPase; pfam08761, dUTPase_2, 2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate; MGRL403 NP_853143.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_853144.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_853145.2 MGA_1283; potential PTS protein fragment, Mannitol-specific EIIB-like domain protein, lacks IIC domain; similar to C-terminus of COG2213, MtlA Phosphotransferase system mannitol-specific IIBC component; pfam02302, PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit; MGRL406 NP_853146.2 MGA_1284; similar to N-terminus of MdlB [Q] COG1132 ABC-type multidrug transport system ATPase component; similar to MGA_1322D; contains 6 predicted transmembrane helices; MGRL408a NP_853147.2 MGA_1285; similar to C-terminus of MdlB [Q] COG1132 ABC-type multidrug transport system ATPase component; pfam00664, ABC_membrane, ABC transporter transmembrane region; cd03251, MsbA ABC transporter domain; similar to MGA_0625, MGA_1287; MGRL408b NP_853148.1 MGA_1287; similar to MdlB [Q] COG1132 ABC-type multidrug transport system ATPase and permease components; contains 5 predicted N-terminal transmembrane helices and C-terminal NTPase domain; MGRL409 NP_853149.2 MGA_1290; RplU [J] COG0261 Ribosomal protein L21; MGRL410 NP_853150.2 MGA_1291; similar to [J] COG2868 predicted ribosomal protein; pfam04327, DUF464, Protein of unknown function (DUF464); MGRL411 NP_853151.1 involved in the peptidyltransferase reaction during translation NP_853152.1 MGA_1293; Nfo [L] COG0648 Endonuclease IV; MGRL413 NP_853153.2 MGA_1295; similar to [P] COG0735 Fe2+/Zn2+ uptake regulation proteins; pfam01475, FUR, Ferric uptake regulator family; MGRL414 NP_853154.2 MGA_1296; MGRL415 NP_853155.2 MGA_1297; Tig [O] COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); pfam05697, Trigger_N, Bacterial trigger factor protein (TF); pfam05698, Trigger_C, Bacterial trigger factor protein (TF) C-terminus, the ribosome-associated Trigger Factor (TF) is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro; MGRL416 NP_853156.2 MGA_1299; Lon [O] COG0466 ATP-dependent Lon protease bacterial type; pfam05362, Lon_C, Lon protease (S16) C-terminal proteolytic domain; PRK10787, DNA-binding ATP-dependent protease La; MGRL417 NP_853157.2 MGA_1302; N-terminal similarity to NosY [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation permease component; contains 6 predicted transmembrane helices; MGRL418 NP_853158.2 MGA_1303; CcmA [Q] COG1131 ABC-type multidrug transport system ATPase component; pfam00005, ABC_tran, ABC transporter; MGRL419 NP_853159.2 MGA_1305; MaoC [I] COG2030 predicted acyl dehydratase; cd03441, R_hydratase_like, (R)-hydratase [(R)-specific enoyl-CoA oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain; MGRL420 NP_853160.2 MGA_1309; [S] COG1692 Uncharacterized protein conserved in bacteria; MGRL422 NP_853161.2 MGA_1310; [H] COG0212 5-formyltetrahydrofolate cyclo-ligase;pfam01812, 5-FTHF_cyc-lig, 5-formyltetrahydrofolate cyclo-ligase family; MGRL423 NP_853162.2 MGA_1313; UvrD [L] COG0210 Superfamily I DNA and RNA helicases; PRK11773, uvrD, DNA-dependent helicase II; MGRL424 NP_853163.2 MGA_1315; MGRL425 NP_853164.2 MGA_0001; similarity to PF00535; glycosyl_transf_2; PS50167 glycosyl-transfrase; MGRL426 NP_853165.2 MGA_0002; MGRL427 NP_853166.2 MGA_0004; contains 2 predicted transmembrane helices; MGRL428 NP_853167.2 MGA_0005; similar to [O] COG0694 Thioredoxin-like proteins and domains; PF01106 NifU-like domain; MGRL429 NP_853168.2 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX NP_853169.1 MGA_0009; [S] COG0327 Uncharacterized conserved protein; fam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologues; MGRL431 NP_853170.2 MGA_0011; [R] COG2384 Predicted SAM-dependent methyltransferase; pfam04816, DUF633, Family of unknown function (DUF633); MGRL432 NP_853171.2 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released NP_853172.2 MGA_0013; DnaG [L] COG0358 DNA primase; MGRL434 NP_853173.2 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_853174.1 MGA_0016; similar to RecO [L] COG1381 Recombinational DNA repair protein (RecF pathway); MGRL436 NP_853175.1 MGA_0018; Era [R] COG1159 GTPases; cd00880, Era_like, Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases; MGRL437 NP_853176.2 MGA_0019; similar to [R] COG0319 predicted metal-dependent hydrolase; pfam02130, UPF0054; MGRL438 NP_853177.2 MGA_0021; contains 1 predicted N-terminal transmembrane helix; MGRL439 NP_853178.2 MGA_0022; similar to SunT [Q] COG2274 ABC-type bacteriocin/lantibiotic exporters contain an N-terminal double-glycine peptidase domain ATP/GTP-binding site motif A (P-loop); cd02424, Peptidase_C39E, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria; PS00017 PDOC00017 2nd half motif for nucleotide binding associated with P-loop; PS50100 QDOC50100 PF00005 ABC transporter; MGRL440 NP_853179.2 MGA_0023; contains 3 predicted transmembrane helices; MGRL441 NP_853180.2 MGA_0027; FtsZ [D] COG0206 Cell division GTPase; pfam00091, Tubulin, Tubulin/FtsZ family, GTPase domain; MGRL442 NP_853181.1 MGA_0028; similar to M. pneumoniae MPN316, M. genitalium MG_233, and compositionally biased proteins; NQ-rich protein; MGRL443 NP_853182.2 MGA_0029; [M] COG0275 predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; MGRL444 NP_853183.2 MraZ; UPF0040; crystal structure shows similarity to AbrB NP_853184.1 MGA_0035; [K] COG1386 Predicted transcriptional regulator containing the HTH domain; pfam04079, DUF387, Putative transcriptional regulators (Ypuh-like); PRK00135, scpB, segregation and condensation protein B; MGRL446 NP_853185.2 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB NP_853186.2 MGA_0039; PlsC [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; pfam01553, Acyltransferase; MGRL448 NP_853187.2 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_853188.2 MGA_0042; similarity to cell cycle protein gpsB; MGRL450 NP_853189.2 MGA_0043; RnhC [L] COG1039 Ribonuclease HIII; MGRL451 NP_853190.1 MGA_0045; PS00013 prokaryotic lipoprotein signal; MGRL452 NP_853191.1 MGA_0046; contains 7 predicted transmembrane helices; MGRL453 NP_853192.1 MGA_0047; LemA [S] COG1704 Uncharacterized conserved protein; pfam04011, LemA, LemA family; contains 1 predicted N-terminal transmembrane helix; MGRL454 NP_853193.2 MGA_0048; C-terminal 650aa similar to proteins in other mollicutes, N-terminal domain of compositional bias; contains 1 predicted transmembrane helix; MGRL455 NP_853194.2 MGA_1317d; potential C-terminal fragment of Mgal gene family 17 protein; contains 1 predicted transmembrane helix; MGRL456a NP_853195.2 MGA_0049; potential fragment of Mgal gene family 17 protein; contains 2 predicted transmembrane helices; MGRL456b NP_853196.2 MGA_1318d; potential fragment of Mgal gene family 17 protein; contains 1 predicted transmembrane helix; MGRL456c NP_853197.1 MGA_0050; potential N-terminal fragment of Mgal gene family 17 protein; contains 2 predicted transmembrane helices; MGRL456d NP_853198.1 MGA_0051; Pfs [F] COG0775 Nucleoside phosphorylase; MGRL457 NP_853199.2 catalyzes the reversible adenylation of nicotinate mononucleotide to nicotinic acid adenine dinucleotide NP_853200.2 MGA_0053; cd01855, YqeH, YqeH. YqeH is an essential GTP-binding protein; COG1161, Predicted GTPases; MGRL459 NP_853201.2 MGA_0056; ParC/GyrA [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit; pfam00521, DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A; PRK05561, DNA topoisomerase IV subunit A; MGRL460 NP_853202.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_853203.2 MGA_0061; HimA/Hup-2 [L] COG0776 bacterial nucleoid DNA-binding protein; MGRL462 NP_853204.2 MGA_0063; similar to large, compositionally biased proteins; NQ-rich protein; MGRL463 YP_003573389.1 MGA_0065; vlhA.1.01 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA; MGRL465 NP_853205.1 MGA_0068; vlhA.1.02 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA; MGRL466 NP_853206.1 MGA_0069; vlhA.1.03 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.4 1.3 9.2; MGRL467 NP_853207.1 MGA_0070; vlhA.1.04 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.4 1.3 9.2; MGRL468 YP_003573390.1 MGA_1351; potential fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGA_t12a; MGRL469 NP_853208.2 MGA_0071; vlhA.1.05 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.3 1.4; vlhA.1.05 lacks vlhA signature motifs (GAA repeat seq. 5' start and conserved sequence flanking start); MGRL470 NP_853209.2 MGA_0073; potential fragment of predicted transposase; similar to C-terminus of [L] COG3328 Transposase and inactivated derivatives; MGA_t12b; MGRL471a NP_853210.1 MGA_0076; vlhA.1.06 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA; MGRL472 NP_853211.1 MGA_0078; vlhA.1.07 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.5 9.2 1.4; MGRL473 YP_003573391.1 MGA_0079; vlhA.1.08a potential C-terminal fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL474a YP_003573392.1 MGA_0080; vlhA.1.08b potential N-terminal fragment of variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); MGRL474b NP_853212.1 MGA_0082; contains 3 predicted transmembrane helices; FKN-rich; MGRL475 NP_853213.2 MGA_0084; contains predicted signal peptidase I cleavage site; MGRL476 NP_853214.2 MGA_0085; TrkA [P] COG0569 K+ transport systems NAD-binding component; fam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD; PRK09496, trkA, potassium transporter peripheral membrane; MGRL477 NP_853215.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_853216.2 MGA_0090; similar to [R] COG1881 Phospholipid-binding protein; pfam01161, PBP, Phosphatidylethanolamine-binding protein; MGRL479 NP_853217.2 MGA_0091; similar to [R] COG1881 Phospholipid-binding protein; MGRL480 NP_853218.2 MGA_0093; ARA1 [R] COG0656 Aldo/keto reductases related to diketogulonate reductase; pfam00248, Aldo_ket_red, Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity; MGRL481 NP_853219.2 MGA_0094; MGRL482 NP_853220.2 MGA_0096; MGRL483 NP_853221.2 MGA_0097; contains 2 predicted trasmembrane helices; MGRL484 NP_853223.2 MGA_0100; PepC [E] COG3579 Aminopeptidase C; pfam03051, Peptidase_C1_2, Peptidase C1-like family. This family is closely related to the Peptidase_C1 family pfam00112, containing several prokaryotic and eukaryotic aminopeptidases and bleomycin hydrolases; MGRL485 NP_853224.2 MGA_0101; PepC [E] COG3579 Aminopeptidase C; pfam03051, Peptidase_C1_2, Peptidase C1-like family. This family is closely related to the Peptidase_C1 family pfam00112, containing several prokaryotic and eukaryotic aminopeptidases and bleomycin hydrolases; MGRL486 NP_853225.2 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_853226.2 MGA_0103; contains 4 predicted transmembrane helices; MGRL488 NP_853227.2 MGA_0104; PepP [E] COG0006 Xaa-Pro aminopeptidase; cd01092, APP-like, Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; pfam00557, Peptidase_M24, metallopeptidase family M24; MGRL489 NP_853228.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif NP_853229.2 MGA_0105; ArcA [E] COG2235 Arginine deiminase; MGRL492 NP_853230.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_853231.2 MGA_0107; MGRL494 NP_853232.2 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_853233.2 MGA_0111; contains 4 predicted transmembrane helices; potential translational start at position 632379 but likely translational start at 632343 by homology and predicted with Prodigal; MGRL496 NP_853234.1 MGA_0112; contains 1 predicted transmembrane helix; MGRL497 NP_853235.2 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides NP_853236.2 MGA_0115; similar to COG1275 Tellurite resistance protein and related permeases; pfam03595, C4-dicarboxylate transporter/malic acid transport protein; MGRL499 NP_853237.2 MGA_0116; vlhA.2.01 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; vlhA.2.01 lacks vlhA signature motifs (GAA repeat seq. 5' start and conserved seq. flanking start); MGRL500 NP_853238.2 MGA_0117; vlhA.2.02 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; vlhA.2.02 lacks vlhA signature motifs (GAA repeat seq. 5' start and conserved seq. flanking start); MGRL501 NP_853239.1 MGA_0119; COG1624, Uncharacterized conserved protein; pfam02457, DUF147, Domain of unknown function DUF147; contains 1 predicted N-terminal transmembrane helix; MGRL502 NP_853240.2 MGA_0121; VacB [K] COG0557 Exoribonucleases; pfam00773, RNB, RNB domain; MGRL503 NP_853241.2 MGA_0122; similar to [U] COG1314 Preprotein translocase subunit SecG; contains 2 predicted transmembrane helices; MGRL504 NP_853242.1 MGA_0123; [S] COG1481 Uncharacterized protein conserved in bacteria; pfam02650, DUF199, Uncharacterized BCR, COG1481; MGRL505 NP_853243.2 MGA_0124; TrxB [O] COG0492 Thioredoxin reductase; MGRL506 NP_853244.1 MGA_0125; contains N-terminal domain similar to helix-turn-helix DNA-binding domains of transcriptional regulators; pfam00392, GntR, Bacterial regulatory proteins, gntR family; smart00345, HTH_GNTR, helix_turn_helix gluconate operon transcriptional repressor; MGRL507 NP_853245.2 MGA_0126; MGRL508 NP_853246.2 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_853247.2 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_853248.2 MGA_0131; pfam02030, Lipoprotein_8, Hypothetical lipoprotein (MG045 family).This family includes hypothetical lipoproteins, the amino terminal part of this protein is related to pfam01547, a family of solute binding proteins. This suggests this family also has a solute binding function; similar to PotD [E] COG0687 Spermidine/putrescine-binding periplasmic protein; contains a predicted signal peptidase I cleavage site; MGRL511 NP_853249.2 MGA_0132; PotC ABC-type spermidine/putrescine transport system permease protein COG1177; MGRL512 NP_853250.2 MGA_0134; PotB ABC-type spermidine/putrescine transport system permease protein COG1176; potential translational start at position 652080 but likely translational start at 652038 by homology and predicted by Prodigal; MGRL513 NP_853251.2 MGA_0135; MalK/PotA ABC-type sugar/spermidine/putrescine transport system permease protein; MGRL514 NP_853252.1 MGA_0137; KDN-rich protein; contains 1 predicted C-terminal transmembrane helix; MGRL515 NP_853253.2 MGA_0141; MGRL516 NP_853254.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_853255.2 MGA_0145; potential transposase fragment, lacks N-terminal domain, similar to MGA_0147; [L] COG3328 Transposase and inactivated derivatives; MGA_t13; MGRL518a NP_853256.2 MGA_0147; potential transposase fragment, lacks N-terminal domain, similar to MGA_0145; [L] COG3328 Transposase and inactivated derivatives; MGA_t14b; MGRL519a NP_853257.2 MGA_0148; potential N-terminal fragment of transposase; MGA_t14a; MGRL519b NP_853258.2 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress NP_853259.2 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_853260.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_853261.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_853262.2 MGA_0157; PfkA [G] COG0205 6-phosphofructokinase; MGRL524 NP_853263.1 MGA_0158; LplA [H] COG0095 Lipoate-protein ligase A; MGRL525 NP_853264.1 MGA_0161; Lpd [C] COG1249 Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes; PRK06416, dihydrolipoamide dehydrogenase; MGRL526 NP_853265.1 MGA_0162; AceF [C] COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; MGRL527 NP_853266.2 MGA_0164; AcoB [C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit ; MGRL528 NP_853267.1 MGA_0165; AcoA [C] COG1071 Thiamine pyrophosphate-dependent dehydrogenases E1 component alpha subunit; MGRL529 NP_853268.1 MGA_0167; HcaD [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; PRK09564, coenzyme A disulfide reductase; MGRL530 NP_853269.2 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_853270.2 MGA_0171; TrkG [P] COG0168 Trk-type K+ transport systems membrane components; MGRL532 NP_853271.2 MGA_0173; TlyC [R] COG1253 Hemolysins and related proteins containing CBS domains; pfam01595, DUF21, Domain of unknown function; contains 4 predicted transmembrane helices in the amino terminus; MGRL533 NP_853272.2 MGA_0174; Dgk [F] COG1428 Deoxynucleoside kinases (DGUO kinase); cd01673, dNK, Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine, guanosine, adenosine, and thymidine kinases; MGRL534 NP_853273.2 MGA_0175; Dgk [F] COG1428 Deoxynucleoside kinases (DGUO kinase); cd01673, dNK, Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine, guanosine, adenosine, and thymidine kinases; MGRL535 NP_853274.1 MGA_0178; ClpA [O] COG0542 ATPases with chaperone activity ATP-binding subunit; pfam07724, AAA_2, ATPase family associated with various cellular activities (AAA); MGRL536 NP_853275.2 MGA_0180; Rnc [K] COG0571 dsRNA-specific ribonuclease; MGRL537 NP_853276.3 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_853277.2 MGA_0183; [R] COG1461 predicted kinase related to dihydroxyacetone kinase; pfam02734, Dak2, DAK2 domain. This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family; MGRL539 NP_853278.1 MGA_0184; MGRL540 NP_853279.1 MGA_0186; RluA [J] COG0564 Pseudouridylate synthases 23S RNA-specific; MGRL541 NP_853280.1 MGA_0188; SpoU [J] COG0566 tRNA/rRNA methyltrasnferases; pfam00588, SpoU_methylase; MGRL542 NP_853281.1 MGA_0190; [R] COG0618 Exopolyphosphatase-related proteins; MGRL543 NP_853282.2 Required for the synthesis of the thiazole moiety NP_853283.1 MGA_0195; MGRL546 NP_853284.2 MGA_0194; MGRL545 NP_853285.1 MGA_0205; similarity to large, compositionally biased proteins including M. genitalium P200 and C-terminal similarity to MGA_0306 and M. pneumoniae cytadherence-associated proteins P200, HMW1; HWM2, HMW3, TopJ, and MPN447; contains 8 enriched in aromatic and glycine residue (EAGR) box domains; MGRL548 NP_853286.2 MGA_0206; SrmB [LKJ] COG0513 Superfamily II DNA and RNA helicases; MGRL549 NP_853287.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_853288.1 MGA_0211; contains 4 predicted transmembrane helices; MGRL551 NP_853289.1 MGA_0212; Hit [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; pfam01230, HIT, HIT domain; MGRL552 NP_853290.1 MGA_0213; similar to M. genitalium MG_028 and M. pneumoniae MPN031; contains 4 predicted transmembrane helices; MGRL553 NP_853291.2 MGA_0214; similar to NusB [K] COG0781 Transcription terminator; similar to pfam01029 NusB family. The NusB protein is involved in the regulation of rRNA biosynthesis by transcriptional antitermination; MGRL554 NP_853292.1 MGA_0215; MGRL555 NP_853293.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_853294.2 MGA_0217; similar to M. penetrans MYPE8730 and MYPE5510; MGRL558 NP_853295.2 MGA_0218; similar to AppF [E] COG4608 ABC-type oligopeptide transport system, ATPase component; MGRL559 NP_853296.2 MGA_0220; DppD [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system ATPase component; MGRL560 NP_853297.1 MGA_0221; DppC [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems permease components; pfam00528, BPD_transp_1, Binding-protein-dependent transport system inner membrane component; MGRL561 YP_003573393.1 MGA_0223; potential N-terminal fragment of ABC-transporter permease; [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; MGRL562a YP_003573394.1 MGA_0224; potential C-terminal fragment of ABC-transporter permease; MGRL562b NP_853298.2 MGA_0226; PDOC00013 prokaryotic lipoprotein signal; contains predicted signal peptidase II cleavage site; MGRL563 YP_003573395.1 MGA_1352; MGRL564 NP_853299.2 MGA_0230; AppF [E] COG4608 ABC-type oligopeptide transport system, ATPase component, and DppF [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; MGRL565 NP_853300.1 MGA_0232; DppD/OppD [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system ATPase component; pfam08352, oligo_HPY, Oligopeptide/dipeptide transporter, C-terminal region; MGRL566 NP_853301.2 MGA_0234; DppC/OppC [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems permease components; MGRL567 NP_853302.1 MGA_0235; DppB/OppB [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems permease components; MGRL568 NP_853303.2 MGA_0237; similar to OppA [E] COG4166 ABC-type oligopeptide transport system, periplasmic component; pfam00496, SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 Middle; PS00013, prokaryotic lipoprotein signal; MGRL569 NP_853304.2 MGA_0241; similar to proteins encoded by M. synoviae and Ureaplasmas; MGRL570 NP_853305.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_853306.2 MGA_0243; AcpD [I] COG1182 Acyl carrier protein phosphodiesterase; PRK01355, azoreductase; PRK00170, azoreductase; MGRL572 NP_853307.2 MGA_0244; limited similarity to M. pneumoniae MPN399; contains 2 predicted transmembrane helices; N-rich protein; MGRL573 NP_853308.1 MGA_0248; PRK13342, replication-associated recombination protein A (rarA) family protein; [L] COG2256 uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase; pfam00004, AAA, ATPase family Associated with various cellular Activities (AAA); MGRL574 NP_853309.1 MGA_0249; [R] COG0313 predicted methyltransferases; pfam00590, TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases; MGRL575 NP_853310.2 MGA_0250; potential unique hypothetical protein fragment; Predicted translational start is 61 amino acids downstream of orthologs in other M.gallisepticum isolates; MGRL576a NP_853311.2 MGA_0252; pfam02566, OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation; COG1764, OsmC, Predicted redox protein, regulator of disulfide bond formation; MGRL577 NP_853312.2 required for 70S ribosome assembly NP_853313.1 MGA_0254; MGRL579 YP_003573396.1 MGA_0256; C-terminal fragment of the M. gallisepticum pvpA protein degenerate in clonal isolate (clone 2) of low passage strain R(low) but intact in high passage derivative strain R(high); MGRL580a YP_003573397.1 MGA_0258; N-terminal fragment of the M. gallisepticum pvpA protein degenerate in clonal isolate (clone 2) of low passage strain R(low) but intact in high passage derivative strain R(high); MGRL580b NP_853314.2 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_853315.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_853316.2 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_853317.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_853318.2 MGA_0267; contains a predicted signal peptidase II cleavage site and an N-terminal Ser-rich repetitive domain; MGRL585 YP_003573398.1 MGA_1353a; potential N-terminal protein fragment; Contains a predicted signal peptidase II cleavage site; MGRL586 YP_003573399.1 MGA_1361; MGRL587 YP_003573400.1 MGA_1362; MGRL588 NP_853319.2 MGA_0271; MGRL589 NP_853320.1 MGA_0274; pfam01732, DUF31, Domain of unknown function DUF31. This domain has no known function. It is found in various hypothetical proteins and putative lipoproteins from mycoplasmas; contains predicted signal peptidase II cleavage site; MGRL590 NP_853321.2 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_853322.1 MGA_0280; [R] COG0392 predicted integral membrane protein; MGRL592 NP_853323.2 MGA_0281; Kch [P] COG1226 Kef-type K+ transport systems predicted NAD-binding component; PRK10537, voltage-gated potassium channel; MGRL593 NP_853324.2 MGA_0284; MscL [M] COG1970 Large-conductance mechanosensitive channel; pfam01741, MscL; MGRL594 NP_853325.2 MGA_0287; similar to PotE [E] COG0531 amino acid transporters; MGRL595 NP_853326.1 MGA_0289; similar to PtsG [G] COG1264 Phosphotransferase system IIB components; MGRL596 NP_853327.1 catalyzes the phosphorylation of NAD to NADP NP_853328.2 MGA_0294; similar to ArsC [P] COG1393 Arsenate reductase and related proteins, glutaredoxin family; cd03032, ArsC_Spx, Arsenate Reductase (ArsC) family, Spx subfamily' Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes; PRK01655, spxA, transcriptional regulator Spx; MGRL598 NP_853329.2 MGA_0293; TrpS [J] COG0180 Tryptophanyl-tRNA syntetase; potential translational start at position 761179 but likely translational start at 761266 by homology; MGRL599 NP_853330.2 MGA_0295; Cof [R] COG0561 predicted hydrolases of the HAD superfamily; pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase; MGRL600 NP_853331.2 MGA_0297; Cof [R] COG0561 predicted hydrolases of the HAD superfamily; pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase; MGRL601 NP_853332.1 MGA_0298; MGRL602 NP_853333.2 MGA_0306; similarity in the N-terminal half to large, compositionally biased proteins including the C-terminal half MGA_0205 and including M. pneumoniae cytadherence-associated proteins P200 and HMW1, contains 7 enriched in aromatic and glycine residue (EAGR) box domains; EQ-rich; MGRL603 NP_853334.2 MGA_0310; similarity to pfam07690, MFS_1, Major Facilitator Superfamily; contains 12 predicted transmembrane helices; MGRL604 NP_853335.2 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_853336.1 MGA_0313; pfam07667, DUF1600, Protein of unknown function (DUF1600). These proteins appear to be specific to Mycoplasma species; Mgal gene family 20 protein; contains 6 predicted transmembrane helices; MGRL606 NP_853337.1 MGA_0315; pfam07667, DUF1600, Protein of unknown function (DUF1600). These proteins appear to be specific to Mycoplasma species; Mgal gene family 20 protein; contains predicted signal peptidase I cleavage site and 6 predicted transmembrane helices; MGRL607 NP_853338.1 MGA_0316; pfam07667, DUF1600, Protein of unknown function (DUF1600). These proteins appear to be specific to Mycoplasma species; Mgal gene family 20 protein; contains 6 predicted transmembrane helices; MGRL608 NP_853339.2 MGA_0319; contains predicted signal peptidase I and II cleavage sites; MGRL609 NP_853340.2 MGA_0321; contains predicted signal peptidase I and II cleavage site; MGRL610 NP_853341.1 MGA_0323; contains 7 predicted transmembrane helices; MGRL611 NP_853342.1 MGA_0324; potential gene fragment, similar to domains of MGA_035; MGRL612 NP_853343.2 MGA_0329; cd00260, Sialidase, Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions; MGRL613 NP_853344.2 MGA_0330; potential gene fragment, C-terminal domain of glyceraldehyde dehydrogenase; C-term of COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; pfam02800, Gp_dh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; MGRL614 NP_853345.2 MGA_0332; contains predicted signal peptidase I and II cleavage sites; MGRL615 NP_853346.2 MGA_0333; similar to M. genitalium MG313 and M. pneumoniae MPN448; contains 6 predicted transmembrane helices; MGRL616 NP_853347.1 MGA_0335; similar to M. genitalium MG314, M. pneumoniae MPN449, and homologues in other mollicutes; contains 4 predicted transmembrane helices; MGRL617 NP_853348.2 MGA_0336; pfam06144, DNA_pol3_delta, DNA polymerase III, delta subunit; MGRL618 NP_853349.2 MGA_0337; similar to pfam03772, Competence, Competence protein. Members of this family are integral membrane proteins with 6 predicted transmembrane helices; contains 9 predicted transmembrane helices; MGRL619 NP_853350.2 MGA_0338; ValS [J] COG0525 Valyl-tRNA synthetase; MGRL620 NP_853351.2 MGA_0339; [R] COG0218 predicted GTPases; PRK00454, GTPase EngB; MGRL621 NP_853352.1 MGA_0340; Uncharacterised HAMAP protein family UPF0154; MGRL622 NP_853353.2 MGA_0342; TktA [G] COG0021 Transketolase; MGRL623 NP_853354.2 MGA_0343; pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; WcaA [M] COG0463 Glycosyltransferases involved in cell wall biogenesis; MGRL624 NP_853355.2 MGA_0344; cd03586, Pol_IV_kappa, Pol_IV_kappa, a member of the Y-family of DNA polymerases; similar to UmuC/DinP [L] COG0389, Nucleotidyltransferase/DNA polymerase involved in DNA repair; pfam00817 IMS impB/mucB/samB family. These proteins are involved in UV protection; MGRL625 NP_853356.2 MGA_0346; [L] COG1658 Small primase-like proteins (Toprim domain); cd01027, TOPRIM_RNase_M5_like, TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea; MGRL626 NP_853357.2 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_853358.2 MGA_1331d; TruA [J] COG0101 Pseudouridylate synthase (tRNA psi55); MGRL628 NP_853359.1 MGA_0351; CbiQ [P] COG0619 ABC-type cobalt transport system permease component CbiQ and related transporters; pfam02361, CbiQ, Cobalt transport protein; MGRL629 NP_853360.1 with CbiNQ forms the ABC transporter for cobalt import; Mycoplasmas have two adjacent copies of this gene NP_853361.1 with CbiNQ forms the ABC transporter for cobalt import; Mycoplasmas have two adjacent copies of this gene NP_853362.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate NP_853363.1 MGA_0357; TpiA [G] COG0149 Triosephosphate isomerase; MGRL633 NP_853364.2 MGA_0358; CpsG [G] COG1109 Phosphomannomutase; pfam02878, PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; MGRL634 NP_853365.2 MGA_0361; Cdd [F] COG0295 Cytidine deaminase; MGRL635 NP_853366.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate NP_853367.2 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_853368.2 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate NP_853369.2 MGA_0365; COG1079, Uncharacterized ABC-type transport system, permease component; similar to proteins annotated as sugar (ribose/galactose) transport permeases in other species; MGRL639 NP_853370.1 MGA_0368; COG4603 and COG1079, ABC-type uncharacterized transport system, permease component; MGRL640 NP_853371.2 MGA_0372; COG3845, ABC-type uncharacterized transport systems, ATPase components; MglA [G] COG1129 ABC-type sugar (aldose) transport system ATPase component; PRK10982, fused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components; similar to sugar (galactose/methylgalactose/ribose) transport components ; MGRL641 YP_003573401.1 MGA_0376; potential fragment of vlhA.3.01 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; MGRL642a YP_003573402.1 MGA_0377; potential fragment of vlhA.3.01 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); MGRL642b NP_853372.2 MGA_0379; vlhA.3.02 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA 1.2; MGRL643 NP_853373.1 MGA_0380; vlhA.3.03 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; pMGA1.2; Lp64; MGRL644 NP_853374.1 MGA_0383; vlhA.3.04 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.3; MGRL645 NP_853375.1 MGA_0386; vlhA.3.05 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.3 1.4; MGRL646 NP_853376.1 MGA_0388; vlhA.3.06 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.3 1.2 1.4; MGRL647 NP_853377.1 MGA_0390; vlhA.3.07 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.2 1.1; MGRL648 NP_853378.1 MGA_0393; vlhA.3.08 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.3 1.4; MGRL649 NP_853379.1 MGA_0395; vlhA.3.09 variably expressed lipoprotein and hemagglutinin (VlhA) family protein (Mgal gene family 1); pfam05692, Myco_haema, Mycoplasma haemagglutinin; similar to pMGA1.4 1.3; MGRL650 NP_853380.1 MGA_0398; Med [N] COG1744 Surface lipoprotein; pfam02608, Bmp, Basic membrane protein. This is a family of basic membrane lipoproteins form Borrelia and various putative lipoproteins form other bacteria; MGRL651 NP_853381.2 involved in a recombinational process of DNA repair, independent of the recBC complex NP_853382.2 MGA_0400; [S] COG0718, Uncharacterized protein conserved in bacteria; pfam02575, DUF149, Uncharacterised BCR, YbaB family; PRK00587, hypothetical protein; MGRL653 NP_853383.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA NP_853384.1 MGA_0403; contains a proline-rich N-terminal domain with similarity to pfam07271, Cytadhesin_P30, Cytadhesin P30/P32. This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localised on the tip organelle. It is thought that it is important in cytadherence and virulence; MGRL655 NP_853385.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_853386.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_853387.1 MGA_0409; MGRL658 NP_853388.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_853389.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_853390.2 contains unknown domain at the N-terminus that is found by itself in some proteins by in others is fused to GatC at the C-terminus NP_853391.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_853392.2 MGA_0416; similarity to M. genitalium MG095 and M. pneumoniae MPN233; N-rich protein; MGRL663 NP_853393.1 MGA_0419; DnaB [L] COG0305 Replicative DNA helicase; MGRL664 NP_853394.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_853395.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_853396.1 MGA_0422; Ssb [L] COG0629 Single-stranded DNA-binding protein; pfam00436, SSB, Single-strand binding protein family. This family includes single stranded binding proteins and the primosomal replication protein N (PriB); MGRL667 NP_853397.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_853398.2 catalyzes the formation of asparagine from aspartate and ammonia NP_853399.2 MGA_0428; PRK09198, hypothetical protein; similar to PncB [H] COG1488 Nicotinic acid phosphoribosyltransferase; similar to pfam04095, NAPRTase, Nicotinate phosphoribosyltransferase (NAPRTase) family; MGRL671 NP_853400.1 MGA_0427; MhpC, COG0596, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes; Mgal gene family 12; MGRL670 NP_853401.2 MGA_0430; pfam09644, Mg296, Mycoplasma pneumoniae Mg296 protein. This protein of 129 residues is expressed in bacteria. It consists of three identical chains of five alpha helices. Two copies of each chain associate into a complex of six units of possible biological significance but of unknown function; MGRL672 NP_853402.1 MGA_0431; Cof COG0561 Predicted hydrolases of the HAD superfamily; pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase family; MGRL673 NP_853403.2 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta NP_853404.2 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) NP_853405.1 MGA_0436; [S] COG1284 Uncharacterized BCR; contains 7 predicted transmembrane domains; similarity to pfam02588, DUF161, Uncharacterized BCR, YitT family COG1284. This is probably a bacterial ABC transporter permease; MGRL676 NP_853406.2 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_853407.1 MGA_0439; TrmD tRNA-(guanine-N1)-methyltransferase COG0336; MGRL678 NP_853408.2 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_853409.2 MGA_0441; RplQ [J] COG0203 Ribosomal protein L17; MGRL680 NP_853410.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_853411.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_853412.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_853413.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_853414.1 MGA_0449; InfA [J] COG0361 Translation initiation factor 1 (IF-1); MGRL685 NP_853415.2 MGA_0452; [O] COG3118 Thioredoxin domain-containing protein; pfam00085, Thioredoxin; MGRL687 NP_853416.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_003573403.1 MGA_1354; contains 3 predicted transmembrane helices; MGRL688 NP_853417.2 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate NP_853418.2 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_853419.1 MGA_0458; [R] COG1162 Predicted GTPases; pfam03193, DUF258, Protein of unknown function; MF_01820, Putative ribosome biogenesis GTPase rsgA; PRK00098, ribosome-associated GTPase; cd01854, YjeQ_engC, YjeQ/EngC; MGRL692 NP_853420.2 MGA_0459; cd00180, S_TKc, Serine/Threonine protein kinases, catalytic domain; pfam00069, Pkinase, Protein kinase domain; MGRL693 NP_853421.2 MGA_0461; PTC1 [T] COG0631 Serine/threonine protein phosphatase; cd00143, PP2Cc, Serine/threonine phosphatases, family 2C, catalytic domain; pfam00481, PP2C, Protein phosphatase 2C; MGRL694 NP_853422.1 MGA_0462; Gmk [F] COG0194 Guanylate kinase; MGRL695 NP_853423.2 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_853424.2 MGA_0468; pfam07672, MFS_Mycoplasma, Mycoplasma MFS transporter. These proteins share some similarity with members of the Major Facilitator Superfamily (MFS); contains 12 predicted transmembrane helices; MGRL697 NP_853425.2 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_853426.1 MGA_0470; GidB [M] COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division; pfam02527, GidB, Glucose inhibited division protein; MGRL699 NP_853427.2 MGA_0471; weak similarity to Soj/ParA-family ATPases; MGRL700 NP_853428.1 MGA_0472; contains 3 predicted transmembrane helices; MGRL701 NP_853429.2 MGA_0473; NusG [K] COG0250 Transcription antiterminator; MGRL702 NP_853430.2 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_003573404.1 MGA_1355; RpmG [J] COG0267 Ribosomal protein L33; MGRL704 NP_853431.1 MGA_0475; potential fragment of predicted transposase; similar to N-terminal region of [L] COG3328 predicted transposase; MGA_t15; MGRL705 NP_853432.1 MGA_0477; MGRL706 NP_853433.2 MGA_0480; conserved in mollicutes; MGRL707 NP_853434.1 MGA_0482; conserved in mollicutes; MGRL708 NP_853435.2 MGA_0484; conserved in mollicutes; MGRL709 NP_853436.2 MGA_0485; N-terminal domain of an approximately 700-800 amino acid ORF conserved in mollicutes; contains predicted signal peptidase I cleavage site; MGRL710a NP_853437.2 MGA_0487; C-terminal domain of an approximately 700-800 amino acid ORF conserved in mollicutes; contains two predicted transmembrane helices; MGRL710b NP_853438.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a catalytic subunit NP_853439.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the beta chain is a regulatory subunit NP_853440.2 MGA_0493; Mgal gene family 14 C-terminal domain protein; contains predicted signal peptidase I cleavage site; MGRL713 NP_853441.2 MGA_0495; Mgal gene family 14 C-terminal domain protein; contains predicted signal peptidase II cleavage site; MGRL714 NP_853442.2 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling NP_853443.2 MGA_0498; Fba [G] COG0191 Fructose/tagatose bisphosphate aldolase; fam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II; MGRL716 NP_853444.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_853445.2 catalyzes the formation of thymidine 5'-phosphate from thymidine NP_853446.1 binds directly to 23S ribosomal RNA NP_853447.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_853448.2 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_853449.1 MGA_0507; similar to MesJ [D] COG0037 predicted ATPase of the PP-loop superfamily implicated in cell cycle control; pfam01171, ATP_bind_3, PP-loop family; HAMAP MF_01161, tilS tRNA(Ile)-lysidine synthase; MGRL722 NP_853450.2 MGA_0508; PTS system fructose-specific IIABC component; PRK09765, fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA component/IIB component/IIC component; COG1762, PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); COG1445, FrwB, Phosphotransferase system fructose-specific component IIB; COG1299, FruA, Phosphotransferase system, fructose-specific IIC component; MGRL723 NP_853451.2 MGA_0512; similarity to mhp491 homologs in Mycoplasma hyopneumoniae; contains predicted signal peptidase I cleavage site; MGRL724 NP_853452.1 MGA_0514; ManA Phosphomannose isomerase COG1482; pfam01238, PMI_typeI, Phosphomannose isomerase type I; MGRL725 NP_853453.2 MGA_0516; N-rich protein; MGRL726 NP_853454.2 MGA_0517; C-terminal domain of subtilisin-like serine protease paralogs present in M. gallisepticum; contains peptidase domain pfam00082, Peptidase_S8, Subtilase family. Subtilases are a family of serine proteases; COG1404, AprE, Subtilisin-like serine proteases; MGRL727a NP_853455.2 MGA_0518; N-terminal domain of subtilisin-like serine protease paralogs present in M. gallisepticum, but lacks similarity to other proteases; MGRL727b NP_853456.2 MGA_0519; COG3513 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain; MGRL728 NP_853457.2 MGA_0523; COG1518 CRISPR-associated protein Cas1; pfam01867, DUF48, Protein of unknown function DUF48; MGRL729 NP_853458.2 MGA_0525; COG3512 CRISPR-associated protein, Cas2 homolog; MGRL730 NP_853459.2 MGA_0526; similar to ORFs in other mycoplasma spp.; MGRL731 NP_853460.1 MGA_0532; SpoU [J] COG0566 rRNA methylases; pfam00588, SpoU_methylase, SpoU rRNA Methylase family; MGRL732 NP_853461.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_853462.1 MGA_0535; conserved in non-mollicutes species; similarity to pfam00082, Peptidase_S8, Subtilase family; MGRL734 NP_853463.1 MGA_0536; similarity to SpoVK [O] COG0464 ATPases of the AAA+ class; pfam00004, AAA, ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes; MGRL735 NP_853464.2 MGA_0537; HsdM [V] COG0286 Type I restriction-modification system methyltransferase subunit; pfam02384, N6_Mtase, N-6 DNA Methylase. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction-modification (R-M) systems systems. These methylases have the same sequence specificity as their corresponding restriction enzymes; MGRL736 NP_853465.2 MGA_0539; similar to domain of HsdS [V] COG0732 Restriction endonuclease S subunits; pfam01420, Methylase_S, Type I restriction modification DNA specificity domain; similar to MGA_0540; MGRL737 NP_853466.2 MGA_0540; similar to domain of HsdS [V] COG0732 Restriction endonuclease S subunits; pfam01420, Methylase_S, Type I restriction modification DNA specificity domain; similar to MGA_0539; MGRL738 NP_853467.1 MGA_0541; [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; MGRL739 NP_853468.1 MGA_0549; MGRL741 NP_853469.1 MGA_0551; MGRL742 NP_853470.2 MGA_0552; similarity to N-terminal domain of M. penetrans MYPE7250; contains predicted signal peptidase I cleavage site; MGRL743 NP_853472.2 MGA_0554; similar to protein family in Mycoplasma penetrans HF-2; contains predicted signal peptidase II cleavage site; MGRL744 NP_853473.2 MGA_0556; contains predicted signal peptidase I cleavage site; MGRL745 NP_853474.1 MGA_0557; similarity to P75/MGA_0556/P75 surface antigen; contains predicted N-terminal signal sequence and transmembrane domain; MGRL746 NP_853475.1 MGA_0558; MGRL747 NP_853476.2 MGA_0562; contains predicted signal peptidase I cleavage site; NQI-rich protein; MGRL750 YP_003573405.1 MGA_0565; similar to N-terminal domain of Mycoplasma synoviae MS53_0470; contains 2 predicted transmembrane helices; MGRL751 NP_853479.2 MGA_0565; contains predicted signal peptidase II cleavage site;potential translational start site at position 967053 but likely translational start at 967101 by homology and predicted by Prodigal; MGRL753 NP_853480.2 MGA_0566; unique hypothetical protein; similarity to N-terminus of MGA_0588 Mgal gene family 5 protein and to M. synoviae MS53_0462 and MS53_0471; divergent coding potential in the surrounding region relative to strain F suggests gene fragmentation; MGRL754 YP_003573406.1 MGA_1358; unique hypothetical protein; divergent coding potential in the surrounding region relative to strain F suggests gene fragmentation; MGRL755 NP_853481.2 MGA_0567; unique hypothetical protein; divergent coding potential in the surrounding region relative to strain F suggests gene fragmentation; MGRL756 NP_853482.2 MGA_0569; Lig [L] COG0272 NAD-dependent DNA ligase (contains BRCT domain type II); MGRL757 NP_853483.2 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress NP_853484.2 MGA_0570; HepA [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family; pfam00176, SNF2_N, SNF2 family N-terminal domain; MGRL760 NP_853485.1 MGA_0573; MGRL761 NP_853486.1 MGA_0576; Mgal gene family 5 protein; MGRL762 YP_003573407.1 MGA_0578d; potential C-terminal fragment of Mgal gene family 5 protein; MGRL763a YP_003573408.1 MGA_0578c; potential fragment of Mgal gene family 5 protein; MGRL763b YP_003573409.1 MGA_0578b; potential fragment of Mgal gene family 5 protein; MGRL763c NP_853487.2 MGA_0578a; potential N-terminal fragment of Mgal gene family 5 protein; contains predicted signal peptidase I cleavage site; MGRL763d NP_853488.2 MGA_0579; contains predicted signal peptidase II cleavage site; MGRL764 NP_853489.2 MGA_0583; potential C-terminal fragment of Mgal gene family 5 protein; MGRL766a NP_853490.2 MGA_0584; potential N-terminal fragment Mgal gene family 5 protein; contains predicted signal peptidase I cleavage site; MGRL766b NP_853491.1 MGA_0586; Mgal gene family 5 protein; contains predicted signal peptidase I cleavage site; MGRL767 NP_853492.2 MGA_0588; Mgal gene family 5 protein; contains predicted signal peptidase I cleavage site; MGRL768 NP_853493.2 MGA_0590; PutA [C] COG1012 NAD-dependent aldehyde dehydrogenases; pfam00171, Aldedh, Aldehyde dehydrogenase family; MGRL769 NP_853494.1 MGA_0591; [R] COG1078 HD superfamily phosphohydrolases; pfam01966, HD, HD domain. HD domains are metal dependent phosphohydrolases; MGRL770 NP_853495.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_853496.2 MGA_0596; FolD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; MF_01576 Bifunctional protein folD; MGRL772 NP_853497.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_853498.2 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system NP_853499.2 MGA_0600; MGRL775 NP_853500.2 MGA_0603; TatD [L] COG0084 Mg-dependent DNase; PF01026 TatD_DNase; MGRL776 NP_853501.2 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_853502.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA NP_853503.2 MGA_0606; Tmk [F] COG0125 Thymidylate kinase; MGRL779 NP_853504.2 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_853505.1 negatively supercoils closed circular double-stranded DNA NP_853506.1 negatively supercoils closed circular double-stranded DNA NP_853507.2 MGA_0617; DnaJ/CbpA Molecular chaperone similar to COG0484 and COG2214; pfam00226, DnaJ, DnaJ domain; MGRL783 NP_853508.2 MGA_0618; DnaN [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog); cd00140, beta_clamp, Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme; MGRL784