-- dump date 20140619_153119 -- class Genbank::misc_feature -- table misc_feature_note -- id note 216594000001 TrwC relaxase; Region: TrwC; pfam08751 216594000002 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 216594000003 AAA domain; Region: AAA_30; pfam13604 216594000004 ribonuclease III; Reviewed; Region: PRK12372 216594000005 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216594000006 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216594000007 catalytic residues [active] 216594000008 catalytic nucleophile [active] 216594000009 Presynaptic Site I dimer interface [polypeptide binding]; other site 216594000010 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216594000011 Synaptic Flat tetramer interface [polypeptide binding]; other site 216594000012 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216594000013 DNA-binding interface [nucleotide binding]; DNA binding site 216594000014 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 216594000015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594000016 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216594000017 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 216594000018 alkylmercury lyase; Provisional; Region: PRK13239 216594000019 Alkylmercury lyase; Region: MerB; pfam03243 216594000020 mercuric reductase; Region: MerA; TIGR02053 216594000021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594000022 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216594000023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594000024 dimerization interface [polypeptide binding]; other site 216594000025 putative DNA binding site [nucleotide binding]; other site 216594000026 putative Zn2+ binding site [ion binding]; other site 216594000027 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216594000028 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216594000029 catalytic residues [active] 216594000030 catalytic nucleophile [active] 216594000031 Presynaptic Site I dimer interface [polypeptide binding]; other site 216594000032 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216594000033 Synaptic Flat tetramer interface [polypeptide binding]; other site 216594000034 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 216594000035 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 216594000036 Abi-like protein; Region: Abi_2; pfam07751 216594000037 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216594000038 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216594000039 P-loop; other site 216594000040 Magnesium ion binding site [ion binding]; other site 216594000041 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 216594000042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216594000043 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 216594000044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594000045 Walker A motif; other site 216594000046 ATP binding site [chemical binding]; other site 216594000047 Walker B motif; other site 216594000048 arginine finger; other site 216594000049 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 216594000050 DnaA box-binding interface [nucleotide binding]; other site 216594000051 DNA polymerase III subunit beta; Validated; Region: PRK07761 216594000052 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 216594000053 putative DNA binding surface [nucleotide binding]; other site 216594000054 dimer interface [polypeptide binding]; other site 216594000055 beta-clamp/clamp loader binding surface; other site 216594000056 beta-clamp/translesion DNA polymerase binding surface; other site 216594000057 recF protein; Region: recf; TIGR00611 216594000058 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 216594000059 Walker A/P-loop; other site 216594000060 ATP binding site [chemical binding]; other site 216594000061 Q-loop/lid; other site 216594000062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594000063 ABC transporter signature motif; other site 216594000064 Walker B; other site 216594000065 D-loop; other site 216594000066 H-loop/switch region; other site 216594000067 hypothetical protein; Provisional; Region: PRK03195 216594000068 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 216594000069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594000070 Mg2+ binding site [ion binding]; other site 216594000071 G-X-G motif; other site 216594000072 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 216594000073 anchoring element; other site 216594000074 dimer interface [polypeptide binding]; other site 216594000075 ATP binding site [chemical binding]; other site 216594000076 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 216594000077 active site 216594000078 putative metal-binding site [ion binding]; other site 216594000079 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216594000080 DNA gyrase subunit A; Validated; Region: PRK05560 216594000081 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 216594000082 CAP-like domain; other site 216594000083 active site 216594000084 primary dimer interface [polypeptide binding]; other site 216594000085 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216594000086 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216594000087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216594000088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216594000089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216594000090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216594000091 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 216594000092 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594000093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594000094 S-adenosylmethionine binding site [chemical binding]; other site 216594000095 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 216594000096 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 216594000097 DNA binding residues [nucleotide binding] 216594000098 dimer interface [polypeptide binding]; other site 216594000099 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 216594000100 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 216594000101 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 216594000102 active site 216594000103 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 216594000104 putative septation inhibitor protein; Reviewed; Region: PRK00159 216594000105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 216594000106 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 216594000107 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 216594000108 Glutamine amidotransferase class-I; Region: GATase; pfam00117 216594000109 glutamine binding [chemical binding]; other site 216594000110 catalytic triad [active] 216594000111 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216594000112 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594000113 active site 216594000114 ATP binding site [chemical binding]; other site 216594000115 substrate binding site [chemical binding]; other site 216594000116 activation loop (A-loop); other site 216594000117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 216594000118 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 216594000119 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 216594000120 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 216594000121 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 216594000122 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594000123 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594000124 active site 216594000125 ATP binding site [chemical binding]; other site 216594000126 substrate binding site [chemical binding]; other site 216594000127 activation loop (A-loop); other site 216594000128 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 216594000129 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216594000130 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 216594000131 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 216594000132 active site 216594000133 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594000134 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594000135 phosphopeptide binding site; other site 216594000136 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 216594000137 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594000138 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594000139 phosphopeptide binding site; other site 216594000140 bacteriophage phiMmar01; MURD1; may be remnant prophage or integrated plasmid locus 216594000141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594000142 non-specific DNA binding site [nucleotide binding]; other site 216594000143 salt bridge; other site 216594000144 sequence-specific DNA binding site [nucleotide binding]; other site 216594000145 Domain of unknown function (DUF955); Region: DUF955; pfam06114 216594000146 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 216594000147 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 216594000148 dimerization interface [polypeptide binding]; other site 216594000149 active site 216594000150 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 216594000151 Helix-turn-helix domain; Region: HTH_17; cl17695 216594000152 classical (c) SDRs; Region: SDR_c; cd05233 216594000153 NAD(P) binding site [chemical binding]; other site 216594000154 active site 216594000155 hypothetical protein; Validated; Region: PRK02101 216594000156 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216594000157 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 216594000158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594000159 dimer interface [polypeptide binding]; other site 216594000160 conserved gate region; other site 216594000161 ABC-ATPase subunit interface; other site 216594000162 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 216594000163 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 216594000164 Walker A/P-loop; other site 216594000165 ATP binding site [chemical binding]; other site 216594000166 Q-loop/lid; other site 216594000167 ABC transporter signature motif; other site 216594000168 Walker B; other site 216594000169 D-loop; other site 216594000170 H-loop/switch region; other site 216594000171 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 216594000172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594000173 putative PBP binding loops; other site 216594000174 dimer interface [polypeptide binding]; other site 216594000175 ABC-ATPase subunit interface; other site 216594000176 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216594000177 DNA-binding site [nucleotide binding]; DNA binding site 216594000178 RNA-binding motif; other site 216594000179 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594000180 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 216594000181 active site 216594000182 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 216594000183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594000184 Coenzyme A binding pocket [chemical binding]; other site 216594000185 Pirin-related protein [General function prediction only]; Region: COG1741 216594000186 Pirin; Region: Pirin; pfam02678 216594000187 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 216594000188 Transcription factor WhiB; Region: Whib; pfam02467 216594000189 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216594000190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594000191 non-specific DNA binding site [nucleotide binding]; other site 216594000192 salt bridge; other site 216594000193 sequence-specific DNA binding site [nucleotide binding]; other site 216594000194 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216594000195 NlpC/P60 family; Region: NLPC_P60; pfam00877 216594000196 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 216594000197 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 216594000198 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 216594000199 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 216594000200 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 216594000201 TIGR03084 family protein; Region: TIGR03084 216594000202 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 216594000203 Wyosine base formation; Region: Wyosine_form; pfam08608 216594000204 H+ Antiporter protein; Region: 2A0121; TIGR00900 216594000205 hypothetical protein; Validated; Region: PRK00228 216594000206 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 216594000207 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 216594000208 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 216594000209 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 216594000210 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216594000211 active site 216594000212 HIGH motif; other site 216594000213 nucleotide binding site [chemical binding]; other site 216594000214 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216594000215 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216594000216 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216594000217 active site 216594000218 KMSKS motif; other site 216594000219 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 216594000220 tRNA binding surface [nucleotide binding]; other site 216594000221 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216594000222 short chain dehydrogenase; Provisional; Region: PRK08219 216594000223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594000224 NAD(P) binding site [chemical binding]; other site 216594000225 active site 216594000226 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216594000227 MarR family; Region: MarR; pfam01047 216594000228 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216594000229 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216594000230 Walker A/P-loop; other site 216594000231 ATP binding site [chemical binding]; other site 216594000232 Q-loop/lid; other site 216594000233 ABC transporter signature motif; other site 216594000234 Walker B; other site 216594000235 D-loop; other site 216594000236 H-loop/switch region; other site 216594000237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216594000238 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216594000239 substrate binding pocket [chemical binding]; other site 216594000240 membrane-bound complex binding site; other site 216594000241 hinge residues; other site 216594000242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594000243 dimer interface [polypeptide binding]; other site 216594000244 conserved gate region; other site 216594000245 putative PBP binding loops; other site 216594000246 ABC-ATPase subunit interface; other site 216594000247 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216594000248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594000249 DNA-binding site [nucleotide binding]; DNA binding site 216594000250 FCD domain; Region: FCD; cl11656 216594000251 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 216594000252 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594000253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594000254 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 216594000255 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 216594000256 Predicted transcriptional regulators [Transcription]; Region: COG1695 216594000257 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216594000258 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 216594000259 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 216594000260 Transglycosylase; Region: Transgly; pfam00912 216594000261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216594000262 Predicted integral membrane protein [Function unknown]; Region: COG5650 216594000263 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 216594000264 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 216594000265 conserved cys residue [active] 216594000266 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 216594000267 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216594000268 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216594000269 dimer interface [polypeptide binding]; other site 216594000270 ssDNA binding site [nucleotide binding]; other site 216594000271 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216594000272 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 216594000273 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 216594000274 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 216594000275 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 216594000276 replicative DNA helicase; Region: DnaB; TIGR00665 216594000277 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 216594000278 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 216594000279 Walker A motif; other site 216594000280 ATP binding site [chemical binding]; other site 216594000281 Walker B motif; other site 216594000282 DNA binding loops [nucleotide binding] 216594000283 MURD2; function unknown; contains two clusters of dehydrogenases and membrane putative membrane proteins. One group may be involved in carbon monoxide metabolism (CoxS,M & L) 216594000284 Beta-lactamase; Region: Beta-lactamase; cl17358 216594000285 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 216594000286 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216594000287 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 216594000288 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216594000289 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 216594000290 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 216594000291 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216594000292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 216594000293 catalytic loop [active] 216594000294 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 216594000295 iron binding site [ion binding]; other site 216594000296 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216594000297 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594000298 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 216594000299 putative NAD(P) binding site [chemical binding]; other site 216594000300 homodimer interface [polypeptide binding]; other site 216594000301 AAA ATPase domain; Region: AAA_16; pfam13191 216594000302 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594000303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594000304 DNA binding residues [nucleotide binding] 216594000305 dimerization interface [polypeptide binding]; other site 216594000306 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 216594000307 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216594000308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594000311 putative transposase OrfB; Reviewed; Region: PHA02517 216594000312 HTH-like domain; Region: HTH_21; pfam13276 216594000313 Integrase core domain; Region: rve; pfam00665 216594000314 Integrase core domain; Region: rve_3; pfam13683 216594000315 Transposase; Region: HTH_Tnp_1; pfam01527 216594000316 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594000317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594000318 putative substrate translocation pore; other site 216594000319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594000320 Transport protein; Region: actII; TIGR00833 216594000321 MURD3; This locus harbours a 34 kbp three-gene cluster encoding a 3-module NRP and two single module PKS for production of an unknown metabolite. The region also contains FAAL and MmpL family genes, their products playing poteintial roles in transferring other metabolites to this system for elongation and export respectively. Other genes in this region encode oxygenases, P450 hydroxlase, dehydrogenases and putative regulatory genes 216594000322 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594000323 MbtH-like protein; Region: MbtH; pfam03621 216594000324 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594000325 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 216594000326 active site 216594000327 Acyl transferase domain; Region: Acyl_transf_1; cl08282 216594000328 Acyl transferase domain; Region: Acyl_transf_1; cl08282 216594000329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594000330 peptide synthase; Provisional; Region: PRK12467 216594000331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594000332 acyl-activating enzyme (AAE) consensus motif; other site 216594000333 AMP binding site [chemical binding]; other site 216594000334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594000335 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594000336 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594000337 acyl-activating enzyme (AAE) consensus motif; other site 216594000338 AMP binding site [chemical binding]; other site 216594000339 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594000340 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216594000341 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594000342 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594000343 acyl-activating enzyme (AAE) consensus motif; other site 216594000344 AMP binding site [chemical binding]; other site 216594000345 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594000346 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 216594000347 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594000348 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594000349 acyl-activating enzyme (AAE) consensus motif; other site 216594000350 AMP binding site [chemical binding]; other site 216594000351 active site 216594000352 CoA binding site [chemical binding]; other site 216594000353 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594000354 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594000355 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594000356 active site 216594000357 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594000358 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594000359 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594000360 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594000361 putative NADP binding site [chemical binding]; other site 216594000362 active site 216594000363 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594000364 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594000365 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594000366 active site 216594000367 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594000368 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594000369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594000370 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594000371 Enoylreductase; Region: PKS_ER; smart00829 216594000372 NAD(P) binding site [chemical binding]; other site 216594000373 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594000374 KR domain; Region: KR; pfam08659 216594000375 putative NADP binding site [chemical binding]; other site 216594000376 active site 216594000377 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594000378 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 216594000379 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 216594000380 2TM domain; Region: 2TM; pfam13239 216594000381 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 216594000382 active site 216594000383 catalytic site [active] 216594000384 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594000385 active site 2 [active] 216594000386 active site 1 [active] 216594000387 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 216594000388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000390 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 216594000391 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 216594000392 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594000393 FAD binding domain; Region: FAD_binding_4; pfam01565 216594000394 Berberine and berberine like; Region: BBE; pfam08031 216594000395 PE family; Region: PE; pfam00934 216594000396 haloalkane dehalogenase; Provisional; Region: PRK03592 216594000397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000399 Nitroreductase family; Region: Nitroreductase; pfam00881 216594000400 FMN binding site [chemical binding]; other site 216594000401 dimer interface [polypeptide binding]; other site 216594000402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594000403 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 216594000404 Walker A motif; other site 216594000405 ATP binding site [chemical binding]; other site 216594000406 Walker B motif; other site 216594000407 arginine finger; other site 216594000408 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 216594000409 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 216594000410 putative molybdopterin cofactor binding site [chemical binding]; other site 216594000411 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 216594000412 putative molybdopterin cofactor binding site; other site 216594000413 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594000414 Cytochrome P450; Region: p450; cl12078 216594000415 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594000416 cyclase homology domain; Region: CHD; cd07302 216594000417 nucleotidyl binding site; other site 216594000418 metal binding site [ion binding]; metal-binding site 216594000419 dimer interface [polypeptide binding]; other site 216594000420 Predicted ATPase [General function prediction only]; Region: COG3903 216594000421 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594000422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594000423 DNA binding residues [nucleotide binding] 216594000424 dimerization interface [polypeptide binding]; other site 216594000425 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594000426 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216594000427 NAD(P) binding site [chemical binding]; other site 216594000428 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216594000429 MarR family; Region: MarR_2; pfam12802 216594000430 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 216594000431 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 216594000432 NAD binding site [chemical binding]; other site 216594000433 catalytic Zn binding site [ion binding]; other site 216594000434 substrate binding site [chemical binding]; other site 216594000435 structural Zn binding site [ion binding]; other site 216594000436 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 216594000437 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594000438 catalytic loop [active] 216594000439 iron binding site [ion binding]; other site 216594000440 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 216594000441 FAD binding pocket [chemical binding]; other site 216594000442 conserved FAD binding motif [chemical binding]; other site 216594000443 phosphate binding motif [ion binding]; other site 216594000444 beta-alpha-beta structure motif; other site 216594000445 NAD binding pocket [chemical binding]; other site 216594000446 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 216594000447 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 216594000448 dimerization interface [polypeptide binding]; other site 216594000449 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 216594000450 dimerization interface [polypeptide binding]; other site 216594000451 putative path to active site cavity [active] 216594000452 diiron center [ion binding]; other site 216594000453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594000454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594000455 active site 216594000456 phosphorylation site [posttranslational modification] 216594000457 intermolecular recognition site; other site 216594000458 dimerization interface [polypeptide binding]; other site 216594000459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594000460 DNA binding residues [nucleotide binding] 216594000461 dimerization interface [polypeptide binding]; other site 216594000462 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216594000463 GAF domain; Region: GAF_2; pfam13185 216594000464 Histidine kinase; Region: HisKA_3; pfam07730 216594000465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594000466 ATP binding site [chemical binding]; other site 216594000467 Mg2+ binding site [ion binding]; other site 216594000468 G-X-G motif; other site 216594000469 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 216594000470 putative active site [active] 216594000471 putative CoA binding site [chemical binding]; other site 216594000472 nudix motif; other site 216594000473 metal binding site [ion binding]; metal-binding site 216594000474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594000475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216594000476 putative substrate translocation pore; other site 216594000477 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 216594000478 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594000479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594000480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594000481 active site 216594000482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594000483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594000484 active site 216594000485 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594000486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000488 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 216594000489 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594000490 active site 216594000491 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 216594000492 DUF35 OB-fold domain; Region: DUF35; pfam01796 216594000493 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216594000494 MarR family; Region: MarR; pfam01047 216594000495 Predicted ATPase [General function prediction only]; Region: COG4637 216594000496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594000497 Walker A/P-loop; other site 216594000498 ATP binding site [chemical binding]; other site 216594000499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594000500 ABC transporter signature motif; other site 216594000501 Walker B; other site 216594000502 D-loop; other site 216594000503 H-loop/switch region; other site 216594000504 CAAX protease self-immunity; Region: Abi; pfam02517 216594000505 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 216594000506 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 216594000507 homodimer interface [polypeptide binding]; other site 216594000508 active site 216594000509 TDP-binding site; other site 216594000510 acceptor substrate-binding pocket; other site 216594000511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594000512 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594000513 active site 216594000514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000516 hypothetical protein; Provisional; Region: PRK01346 216594000517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594000518 Coenzyme A binding pocket [chemical binding]; other site 216594000519 Predicted transcriptional regulators [Transcription]; Region: COG1695 216594000520 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216594000521 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 216594000522 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594000523 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 216594000524 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594000525 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 216594000526 putative active site [active] 216594000527 putative substrate binding site [chemical binding]; other site 216594000528 ATP binding site [chemical binding]; other site 216594000529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594000530 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594000531 active site 216594000532 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594000533 cyclase homology domain; Region: CHD; cd07302 216594000534 nucleotidyl binding site; other site 216594000535 metal binding site [ion binding]; metal-binding site 216594000536 dimer interface [polypeptide binding]; other site 216594000537 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 216594000538 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 216594000539 Mannan-binding protein; Region: MVL; pfam12151 216594000540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594000541 Coenzyme A binding pocket [chemical binding]; other site 216594000542 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 216594000543 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 216594000544 putative NADP binding site [chemical binding]; other site 216594000545 putative substrate binding site [chemical binding]; other site 216594000546 active site 216594000547 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 216594000548 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594000549 inhibitor-cofactor binding pocket; inhibition site 216594000550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594000551 catalytic residue [active] 216594000552 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594000553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594000554 catalytic residue [active] 216594000555 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216594000556 hydrophobic ligand binding site; other site 216594000557 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216594000558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594000559 Walker A/P-loop; other site 216594000560 ATP binding site [chemical binding]; other site 216594000561 Q-loop/lid; other site 216594000562 ABC transporter signature motif; other site 216594000563 Walker B; other site 216594000564 D-loop; other site 216594000565 H-loop/switch region; other site 216594000566 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594000567 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 216594000568 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594000569 acyl-activating enzyme (AAE) consensus motif; other site 216594000570 active site 216594000571 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594000572 Permease; Region: Permease; pfam02405 216594000573 Permease; Region: Permease; pfam02405 216594000574 mce related protein; Region: MCE; pfam02470 216594000575 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594000576 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 216594000577 mce related protein; Region: MCE; pfam02470 216594000578 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594000579 mce related protein; Region: MCE; pfam02470 216594000580 mce related protein; Region: MCE; pfam02470 216594000581 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594000582 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594000583 mce related protein; Region: MCE; pfam02470 216594000584 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594000585 mce related protein; Region: MCE; pfam02470 216594000586 PE family; Region: PE; pfam00934 216594000587 ESX-6 216594000588 MURD4; Spans two Esat6-like loci. This region includes PE and PPE genes, other genes encoding predicted membrane proteins and two distinct clusters of esx genes. These regions are similar but are not identical to the ESX1 (RD1) region of MTB 216594000589 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 216594000590 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594000591 PPE family; Region: PPE; pfam00823 216594000592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 216594000593 Proteins of 100 residues with WXG; Region: WXG100; cl02005 216594000594 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594000595 PPE family; Region: PPE; pfam00823 216594000596 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594000597 Proteins of 100 residues with WXG; Region: WXG100; cl02005 216594000598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000599 hypothetical protein; Validated; Region: PRK07121 216594000600 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 216594000601 Predicted oxidoreductase [General function prediction only]; Region: COG3573 216594000602 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 216594000603 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216594000604 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 216594000605 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 216594000606 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 216594000607 dimer interface [polypeptide binding]; other site 216594000608 active site 216594000609 glycine-pyridoxal phosphate binding site [chemical binding]; other site 216594000610 folate binding site [chemical binding]; other site 216594000611 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 216594000612 lipoyl attachment site [posttranslational modification]; other site 216594000613 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 216594000614 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 216594000615 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216594000616 glycine dehydrogenase; Provisional; Region: PRK05367 216594000617 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216594000618 tetramer interface [polypeptide binding]; other site 216594000619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594000620 catalytic residue [active] 216594000621 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216594000622 tetramer interface [polypeptide binding]; other site 216594000623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594000624 catalytic residue [active] 216594000625 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594000626 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216594000627 [2Fe-2S] cluster binding site [ion binding]; other site 216594000628 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216594000629 hydrophobic ligand binding site; other site 216594000630 MURD5; function unknown but may be required for amino-acid import and degradation. Contains an amino acid hydrolase and four genes encoding putative membrane proteins, two of whcih may be ABC transporters involved in glutamine transport 216594000631 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594000632 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 216594000633 active site 216594000634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594000635 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216594000636 anti sigma factor interaction site; other site 216594000637 regulatory phosphorylation site [posttranslational modification]; other site 216594000638 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216594000639 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216594000640 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216594000641 Walker A/P-loop; other site 216594000642 ATP binding site [chemical binding]; other site 216594000643 Q-loop/lid; other site 216594000644 ABC transporter signature motif; other site 216594000645 Walker B; other site 216594000646 D-loop; other site 216594000647 H-loop/switch region; other site 216594000648 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594000649 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594000650 ligand binding site [chemical binding]; other site 216594000651 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 216594000652 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594000653 Acyltransferase family; Region: Acyl_transf_3; pfam01757 216594000654 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 216594000655 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 216594000656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594000658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000662 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 216594000663 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594000664 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 216594000665 putative DNA binding site [nucleotide binding]; other site 216594000666 putative Zn2+ binding site [ion binding]; other site 216594000667 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 216594000668 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594000669 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216594000670 [2Fe-2S] cluster binding site [ion binding]; other site 216594000671 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 216594000672 putative alpha subunit interface [polypeptide binding]; other site 216594000673 putative active site [active] 216594000674 putative substrate binding site [chemical binding]; other site 216594000675 Fe binding site [ion binding]; other site 216594000676 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216594000677 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216594000678 metal-binding site [ion binding] 216594000679 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594000680 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 216594000681 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216594000682 metal-binding site [ion binding] 216594000683 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 216594000684 putative hydrophobic ligand binding site [chemical binding]; other site 216594000685 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216594000686 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594000687 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594000688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000692 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594000693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594000694 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594000695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594000696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594000697 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 216594000698 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 216594000699 NAD binding site [chemical binding]; other site 216594000700 catalytic Zn binding site [ion binding]; other site 216594000701 substrate binding site [chemical binding]; other site 216594000702 structural Zn binding site [ion binding]; other site 216594000703 PE family; Region: PE; pfam00934 216594000704 short chain dehydrogenase; Provisional; Region: PRK06940 216594000705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594000706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594000707 active site 216594000708 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594000709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594000710 S-adenosylmethionine binding site [chemical binding]; other site 216594000711 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594000712 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594000713 substrate binding site [chemical binding]; other site 216594000714 oxyanion hole (OAH) forming residues; other site 216594000715 trimer interface [polypeptide binding]; other site 216594000716 Predicted membrane protein [Function unknown]; Region: COG3305 216594000717 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594000718 CoenzymeA binding site [chemical binding]; other site 216594000719 subunit interaction site [polypeptide binding]; other site 216594000720 PHB binding site; other site 216594000721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594000722 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 216594000723 NAD(P) binding site [chemical binding]; other site 216594000724 active site 216594000725 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 216594000726 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 216594000727 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 216594000728 putative hydrophobic ligand binding site [chemical binding]; other site 216594000729 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216594000730 classical (c) SDRs; Region: SDR_c; cd05233 216594000731 NAD(P) binding site [chemical binding]; other site 216594000732 active site 216594000733 Transport protein; Region: actII; TIGR00833 216594000734 AMP-binding enzyme; Region: AMP-binding; pfam00501 216594000735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594000736 acyl-activating enzyme (AAE) consensus motif; other site 216594000737 AMP binding site [chemical binding]; other site 216594000738 active site 216594000739 CoA binding site [chemical binding]; other site 216594000740 thioester reductase domain; Region: Thioester-redct; TIGR01746 216594000741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594000742 NAD(P) binding site [chemical binding]; other site 216594000743 active site 216594000744 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216594000745 acyl-CoA synthetase; Validated; Region: PRK05857 216594000746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594000747 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 216594000748 acyl-activating enzyme (AAE) consensus motif; other site 216594000749 acyl-activating enzyme (AAE) consensus motif; other site 216594000750 AMP binding site [chemical binding]; other site 216594000751 active site 216594000752 CoA binding site [chemical binding]; other site 216594000753 FcoT-like thioesterase domain; Region: FcoT; pfam10862 216594000754 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 216594000755 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 216594000756 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594000757 PPE family; Region: PPE; pfam00823 216594000758 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594000759 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 216594000760 Predicted integral membrane protein [Function unknown]; Region: COG5660 216594000761 Putative zinc-finger; Region: zf-HC2; pfam13490 216594000762 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216594000763 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216594000764 metal-binding site [ion binding] 216594000765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594000766 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594000767 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 216594000768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594000769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594000770 DNA binding residues [nucleotide binding] 216594000771 Predicted membrane protein [Function unknown]; Region: COG3336 216594000772 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216594000773 metal-binding site [ion binding] 216594000774 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216594000775 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216594000776 metal-binding site [ion binding] 216594000777 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594000778 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216594000779 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216594000780 classical (c) SDRs; Region: SDR_c; cd05233 216594000781 NAD(P) binding site [chemical binding]; other site 216594000782 active site 216594000783 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594000784 Cytochrome P450; Region: p450; cl12078 216594000785 MURD6; Four CDS in this region encode P450 hydroxlases and the presence of gcpE, dxs2, lytB2 and idsB suggest this is a locus involved in isoprenoid biosynthesis via the non- mevalonate pathway 216594000786 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594000787 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594000788 Cytochrome P450; Region: p450; cl12078 216594000789 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 216594000790 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 216594000791 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 216594000792 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 216594000793 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 216594000794 TPP-binding site; other site 216594000795 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216594000796 PYR/PP interface [polypeptide binding]; other site 216594000797 dimer interface [polypeptide binding]; other site 216594000798 TPP binding site [chemical binding]; other site 216594000799 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216594000800 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 216594000801 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 216594000802 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 216594000803 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 216594000804 substrate binding pocket [chemical binding]; other site 216594000805 substrate-Mg2+ binding site; other site 216594000806 aspartate-rich region 1; other site 216594000807 aspartate-rich region 2; other site 216594000808 Cytochrome P450; Region: p450; cl12078 216594000809 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594000810 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216594000811 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216594000812 substrate binding pocket [chemical binding]; other site 216594000813 chain length determination region; other site 216594000814 substrate-Mg2+ binding site; other site 216594000815 catalytic residues [active] 216594000816 aspartate-rich region 1; other site 216594000817 active site lid residues [active] 216594000818 aspartate-rich region 2; other site 216594000819 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594000820 Cytochrome P450; Region: p450; cl12078 216594000821 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216594000822 Phosphoesterase family; Region: Phosphoesterase; pfam04185 216594000823 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 216594000824 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594000825 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594000826 ligand binding site [chemical binding]; other site 216594000827 flexible hinge region; other site 216594000828 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594000829 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594000830 cyclase homology domain; Region: CHD; cd07302 216594000831 nucleotidyl binding site; other site 216594000832 metal binding site [ion binding]; metal-binding site 216594000833 dimer interface [polypeptide binding]; other site 216594000834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594000835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000836 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 216594000837 30S ribosomal protein S18; Provisional; Region: PRK13401 216594000838 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 216594000839 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 216594000840 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 216594000841 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216594000842 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216594000843 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 216594000844 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 216594000845 short chain dehydrogenase; Provisional; Region: PRK07454 216594000846 classical (c) SDRs; Region: SDR_c; cd05233 216594000847 NAD(P) binding site [chemical binding]; other site 216594000848 active site 216594000849 acyl-CoA synthetase; Provisional; Region: PRK13383 216594000850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594000851 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594000852 AMP binding site [chemical binding]; other site 216594000853 active site 216594000854 acyl-activating enzyme (AAE) consensus motif; other site 216594000855 CoA binding site [chemical binding]; other site 216594000856 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594000857 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 216594000858 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 216594000859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594000860 motif II; other site 216594000861 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216594000862 PE family; Region: PE; pfam00934 216594000863 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 216594000864 Zn2+ binding site [ion binding]; other site 216594000865 Rhomboid family; Region: Rhomboid; pfam01694 216594000866 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216594000867 hydrophobic ligand binding site; other site 216594000868 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216594000869 classical (c) SDRs; Region: SDR_c; cd05233 216594000870 NAD(P) binding site [chemical binding]; other site 216594000871 active site 216594000872 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 216594000873 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 216594000874 acyl-activating enzyme (AAE) consensus motif; other site 216594000875 putative AMP binding site [chemical binding]; other site 216594000876 putative active site [active] 216594000877 putative CoA binding site [chemical binding]; other site 216594000878 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216594000879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594000880 DNA-binding site [nucleotide binding]; DNA binding site 216594000881 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 216594000882 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216594000883 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 216594000884 classical (c) SDRs; Region: SDR_c; cd05233 216594000885 NAD(P) binding site [chemical binding]; other site 216594000886 active site 216594000887 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594000888 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216594000889 [2Fe-2S] cluster binding site [ion binding]; other site 216594000890 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216594000891 hydrophobic ligand binding site; other site 216594000892 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594000893 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594000894 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 216594000895 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594000896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594000897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594000898 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 216594000899 NAD(P) binding site [chemical binding]; other site 216594000900 active site 216594000901 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594000902 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594000903 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216594000904 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 216594000905 active site 216594000906 catalytic triad [active] 216594000907 oxyanion hole [active] 216594000908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594000909 S-adenosylmethionine binding site [chemical binding]; other site 216594000910 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 216594000911 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 216594000912 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 216594000913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216594000914 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216594000915 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216594000916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216594000917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216594000918 dimerization interface [polypeptide binding]; other site 216594000919 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 216594000920 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216594000921 PYR/PP interface [polypeptide binding]; other site 216594000922 dimer interface [polypeptide binding]; other site 216594000923 TPP binding site [chemical binding]; other site 216594000924 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216594000925 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 216594000926 TPP-binding site; other site 216594000927 dimer interface [polypeptide binding]; other site 216594000928 acyl-CoA synthetase; Validated; Region: PRK05852 216594000929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594000930 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 216594000931 acyl-activating enzyme (AAE) consensus motif; other site 216594000932 acyl-activating enzyme (AAE) consensus motif; other site 216594000933 putative AMP binding site [chemical binding]; other site 216594000934 putative active site [active] 216594000935 putative CoA binding site [chemical binding]; other site 216594000936 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 216594000937 elongation factor G; Reviewed; Region: PRK12740 216594000938 G1 box; other site 216594000939 putative GEF interaction site [polypeptide binding]; other site 216594000940 GTP/Mg2+ binding site [chemical binding]; other site 216594000941 Switch I region; other site 216594000942 G2 box; other site 216594000943 G3 box; other site 216594000944 Switch II region; other site 216594000945 G4 box; other site 216594000946 G5 box; other site 216594000947 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 216594000948 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 216594000949 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 216594000950 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 216594000951 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 216594000952 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 216594000953 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216594000954 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216594000955 protein binding site [polypeptide binding]; other site 216594000956 trehalose synthase; Region: treS_nterm; TIGR02456 216594000957 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 216594000958 active site 216594000959 catalytic site [active] 216594000960 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 216594000961 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 216594000962 Predicted membrane protein [Function unknown]; Region: COG3619 216594000963 Putative esterase; Region: Esterase; pfam00756 216594000964 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 216594000965 active site 216594000966 metal binding site [ion binding]; metal-binding site 216594000967 homotetramer interface [polypeptide binding]; other site 216594000968 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 216594000969 putative active site [active] 216594000970 putative catalytic site [active] 216594000971 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594000972 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594000973 active site 216594000974 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 216594000975 Coenzyme A binding pocket [chemical binding]; other site 216594000976 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594000977 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594000978 ligand binding site [chemical binding]; other site 216594000979 flexible hinge region; other site 216594000980 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594000981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594000982 ligand binding site [chemical binding]; other site 216594000983 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 216594000984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594000985 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 216594000986 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216594000987 FAD binding pocket [chemical binding]; other site 216594000988 FAD binding motif [chemical binding]; other site 216594000989 phosphate binding motif [ion binding]; other site 216594000990 beta-alpha-beta structure motif; other site 216594000991 NAD binding pocket [chemical binding]; other site 216594000992 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594000993 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216594000994 catalytic loop [active] 216594000995 iron binding site [ion binding]; other site 216594000996 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 216594000997 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 216594000998 putative di-iron ligands [ion binding]; other site 216594000999 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216594001000 hydrophobic ligand binding site; other site 216594001001 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 216594001002 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594001003 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594001004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001006 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594001007 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594001008 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216594001009 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 216594001010 putative NAD(P) binding site [chemical binding]; other site 216594001011 catalytic Zn binding site [ion binding]; other site 216594001012 structural Zn binding site [ion binding]; other site 216594001013 TOBE domain; Region: TOBE; cl01440 216594001014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001016 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594001017 Cytochrome P450; Region: p450; cl12078 216594001018 methionine sulfoxide reductase A; Provisional; Region: PRK14054 216594001019 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594001020 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 216594001021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594001022 NAD(P) binding site [chemical binding]; other site 216594001023 active site 216594001024 Domain of unknown function (DUF427); Region: DUF427; cl00998 216594001025 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 216594001026 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 216594001027 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216594001028 minor groove reading motif; other site 216594001029 helix-hairpin-helix signature motif; other site 216594001030 active site 216594001031 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 216594001032 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 216594001033 Cl- selectivity filter; other site 216594001034 Cl- binding residues [ion binding]; other site 216594001035 pore gating glutamate residue; other site 216594001036 dimer interface [polypeptide binding]; other site 216594001037 Pirin-related protein [General function prediction only]; Region: COG1741 216594001038 Pirin; Region: Pirin; pfam02678 216594001039 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 216594001040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001042 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594001043 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594001044 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594001045 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594001046 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594001047 Leucine carboxyl methyltransferase; Region: LCM; cl01306 216594001048 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 216594001049 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 216594001050 NAD(P) binding site [chemical binding]; other site 216594001051 catalytic residues [active] 216594001052 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 216594001053 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 216594001054 homodimer interface [polypeptide binding]; other site 216594001055 NAD binding site [chemical binding]; other site 216594001056 active site 216594001057 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216594001058 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 216594001059 NAD(P) binding site [chemical binding]; other site 216594001060 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216594001061 FMN binding site [chemical binding]; other site 216594001062 dimer interface [polypeptide binding]; other site 216594001063 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594001064 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594001065 active site 216594001066 ATP binding site [chemical binding]; other site 216594001067 substrate binding site [chemical binding]; other site 216594001068 activation loop (A-loop); other site 216594001069 Predicted ATPase [General function prediction only]; Region: COG3903 216594001070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594001071 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594001072 active site 216594001073 ATP binding site [chemical binding]; other site 216594001074 substrate binding site [chemical binding]; other site 216594001075 activation loop (A-loop); other site 216594001076 Predicted ATPase [General function prediction only]; Region: COG3903 216594001077 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 216594001078 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594001079 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594001080 active site 216594001081 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594001082 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594001083 acyl-activating enzyme (AAE) consensus motif; other site 216594001084 AMP binding site [chemical binding]; other site 216594001085 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594001086 Condensation domain; Region: Condensation; pfam00668 216594001087 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594001088 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594001089 Condensation domain; Region: Condensation; pfam00668 216594001090 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594001091 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594001092 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594001093 acyl-activating enzyme (AAE) consensus motif; other site 216594001094 AMP binding site [chemical binding]; other site 216594001095 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594001096 Condensation domain; Region: Condensation; pfam00668 216594001097 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594001098 PE family; Region: PE; pfam00934 216594001099 PE-PPE domain; Region: PE-PPE; pfam08237 216594001100 PE family; Region: PE; pfam00934 216594001101 PE-PPE domain; Region: PE-PPE; pfam08237 216594001102 PE family; Region: PE; pfam00934 216594001103 PE-PPE domain; Region: PE-PPE; pfam08237 216594001104 PE family; Region: PE; pfam00934 216594001105 PE-PPE domain; Region: PE-PPE; pfam08237 216594001106 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 216594001107 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 216594001108 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 216594001109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594001110 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 216594001111 FAD binding site [chemical binding]; other site 216594001112 substrate binding site [chemical binding]; other site 216594001113 catalytic base [active] 216594001114 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594001115 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 216594001116 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 216594001117 ligand binding site [chemical binding]; other site 216594001118 homodimer interface [polypeptide binding]; other site 216594001119 NAD(P) binding site [chemical binding]; other site 216594001120 trimer interface B [polypeptide binding]; other site 216594001121 trimer interface A [polypeptide binding]; other site 216594001122 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 216594001123 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 216594001124 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 216594001125 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 216594001126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001128 PE family; Region: PE; pfam00934 216594001129 PE-PPE domain; Region: PE-PPE; pfam08237 216594001130 PE family; Region: PE; pfam00934 216594001131 PE-PPE domain; Region: PE-PPE; pfam08237 216594001132 PE family; Region: PE; pfam00934 216594001133 PE-PPE domain; Region: PE-PPE; pfam08237 216594001134 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216594001135 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594001136 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 216594001137 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216594001138 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 216594001139 homotetramer interface [polypeptide binding]; other site 216594001140 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594001141 NAD binding site [chemical binding]; other site 216594001142 homodimer interface [polypeptide binding]; other site 216594001143 active site 216594001144 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594001145 FAD binding domain; Region: FAD_binding_4; pfam01565 216594001146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001148 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 216594001149 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216594001150 Strictosidine synthase; Region: Str_synth; pfam03088 216594001151 acyl-CoA thioesterase II; Region: tesB; TIGR00189 216594001152 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 216594001153 active site 216594001154 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 216594001155 catalytic triad [active] 216594001156 dimer interface [polypeptide binding]; other site 216594001157 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594001158 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594001159 Domain of unknown function (DUF427); Region: DUF427; cl00998 216594001160 Domain of unknown function (DUF427); Region: DUF427; pfam04248 216594001161 Ecdysteroid kinase; Region: EcKinase; cl17738 216594001162 Phosphotransferase enzyme family; Region: APH; pfam01636 216594001163 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594001164 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594001165 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594001166 Cytochrome P450; Region: p450; cl12078 216594001167 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594001168 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216594001169 NAD(P) binding site [chemical binding]; other site 216594001170 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 216594001171 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594001172 classical (c) SDRs; Region: SDR_c; cd05233 216594001173 NAD(P) binding site [chemical binding]; other site 216594001174 active site 216594001175 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594001176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594001177 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594001178 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594001179 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 216594001180 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594001181 NAD(P) binding site [chemical binding]; other site 216594001182 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216594001183 active site 216594001184 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 216594001185 putative hydrophobic ligand binding site [chemical binding]; other site 216594001186 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216594001187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594001188 DNA-binding site [nucleotide binding]; DNA binding site 216594001189 FCD domain; Region: FCD; pfam07729 216594001190 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 216594001191 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594001192 acyl-activating enzyme (AAE) consensus motif; other site 216594001193 AMP binding site [chemical binding]; other site 216594001194 active site 216594001195 CoA binding site [chemical binding]; other site 216594001196 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594001197 Permease; Region: Permease; pfam02405 216594001198 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594001199 Permease; Region: Permease; pfam02405 216594001200 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594001201 mce related protein; Region: MCE; pfam02470 216594001202 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594001203 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594001204 mce related protein; Region: MCE; pfam02470 216594001205 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594001206 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594001207 mce related protein; Region: MCE; pfam02470 216594001208 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594001209 mce related protein; Region: MCE; pfam02470 216594001210 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594001211 mce related protein; Region: MCE; pfam02470 216594001212 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216594001213 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594001214 mce related protein; Region: MCE; pfam02470 216594001215 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 216594001216 Predicted membrane protein [Function unknown]; Region: COG1511 216594001217 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 216594001218 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 216594001219 Pirin-related protein [General function prediction only]; Region: COG1741 216594001220 Pirin; Region: Pirin; pfam02678 216594001221 RNA polymerase factor sigma-70; Validated; Region: PRK08241 216594001222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594001223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594001224 DNA binding residues [nucleotide binding] 216594001225 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594001226 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216594001227 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594001228 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 216594001229 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 216594001230 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 216594001231 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 216594001232 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 216594001233 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 216594001234 PE family; Region: PE; pfam00934 216594001235 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 216594001236 6-phosphogluconate dehydratase; Region: edd; TIGR01196 216594001237 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 216594001238 putative homodimer interface [polypeptide binding]; other site 216594001239 putative homotetramer interface [polypeptide binding]; other site 216594001240 putative allosteric switch controlling residues; other site 216594001241 putative metal binding site [ion binding]; other site 216594001242 putative homodimer-homodimer interface [polypeptide binding]; other site 216594001243 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216594001244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594001245 putative substrate translocation pore; other site 216594001246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216594001247 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 216594001248 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216594001249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001251 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 216594001252 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216594001253 molybdopterin cofactor binding site; other site 216594001254 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216594001255 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 216594001256 putative molybdopterin cofactor binding site; other site 216594001257 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 216594001258 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 216594001259 active site 216594001260 Zn binding site [ion binding]; other site 216594001261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594001262 non-specific DNA binding site [nucleotide binding]; other site 216594001263 salt bridge; other site 216594001264 sequence-specific DNA binding site [nucleotide binding]; other site 216594001265 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594001266 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 216594001267 Predicted integral membrane protein [Function unknown]; Region: COG0392 216594001268 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216594001269 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216594001270 MMPL family; Region: MMPL; pfam03176 216594001271 MMPL family; Region: MMPL; pfam03176 216594001272 LabA_like proteins; Region: LabA_like; cd06167 216594001273 putative metal binding site [ion binding]; other site 216594001274 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 216594001275 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 216594001276 G2 box; other site 216594001277 Switch I region; other site 216594001278 G3 box; other site 216594001279 Switch II region; other site 216594001280 G4 box; other site 216594001281 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 216594001282 active site 216594001283 substrate-binding site [chemical binding]; other site 216594001284 metal-binding site [ion binding] 216594001285 GTP binding site [chemical binding]; other site 216594001286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594001287 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 216594001288 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 216594001289 acyl-activating enzyme (AAE) consensus motif; other site 216594001290 acyl-activating enzyme (AAE) consensus motif; other site 216594001291 putative AMP binding site [chemical binding]; other site 216594001292 putative active site [active] 216594001293 putative CoA binding site [chemical binding]; other site 216594001294 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594001295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594001296 substrate binding site [chemical binding]; other site 216594001297 oxyanion hole (OAH) forming residues; other site 216594001298 trimer interface [polypeptide binding]; other site 216594001299 Interferon-induced transmembrane protein; Region: CD225; pfam04505 216594001300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594001301 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594001302 active site 216594001303 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 216594001304 putative active site [active] 216594001305 putative catalytic site [active] 216594001306 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594001307 active site 2 [active] 216594001308 active site 1 [active] 216594001309 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594001310 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 216594001311 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594001312 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594001313 active site 216594001314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594001315 S-adenosylmethionine binding site [chemical binding]; other site 216594001316 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 216594001317 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 216594001318 Moco binding site; other site 216594001319 metal coordination site [ion binding]; other site 216594001320 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594001321 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594001322 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594001323 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594001324 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 216594001325 enoyl-CoA hydratase; Provisional; Region: PRK08252 216594001326 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594001327 substrate binding site [chemical binding]; other site 216594001328 oxyanion hole (OAH) forming residues; other site 216594001329 trimer interface [polypeptide binding]; other site 216594001330 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594001331 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594001332 acyl-activating enzyme (AAE) consensus motif; other site 216594001333 AMP binding site [chemical binding]; other site 216594001334 active site 216594001335 CoA binding site [chemical binding]; other site 216594001336 acyl-CoA synthetase; Validated; Region: PRK05850 216594001337 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594001338 acyl-activating enzyme (AAE) consensus motif; other site 216594001339 active site 216594001340 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594001341 FkbH-like domain; Region: FkbH; TIGR01686 216594001342 Acid Phosphatase; Region: Acid_PPase; cl17256 216594001343 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594001344 thioester reductase domain; Region: Thioester-redct; TIGR01746 216594001345 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 216594001346 putative NAD(P) binding site [chemical binding]; other site 216594001347 active site 216594001348 putative substrate binding site [chemical binding]; other site 216594001349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001351 enoyl-CoA hydratase; Provisional; Region: PRK06563 216594001352 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594001353 substrate binding site [chemical binding]; other site 216594001354 oxyanion hole (OAH) forming residues; other site 216594001355 trimer interface [polypeptide binding]; other site 216594001356 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 216594001357 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594001358 NAD binding site [chemical binding]; other site 216594001359 catalytic residues [active] 216594001360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594001361 S-adenosylmethionine binding site [chemical binding]; other site 216594001362 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216594001363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594001364 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 216594001365 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216594001366 PE family; Region: PE; pfam00934 216594001367 PE family; Region: PE; pfam00934 216594001368 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 216594001369 active site 216594001370 substrate binding pocket [chemical binding]; other site 216594001371 homodimer interaction site [polypeptide binding]; other site 216594001372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594001373 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594001374 active site 216594001375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001377 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 216594001378 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 216594001379 NAD(P) binding site [chemical binding]; other site 216594001380 catalytic residues [active] 216594001381 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001382 PPE family; Region: PPE; pfam00823 216594001383 PE family; Region: PE; pfam00934 216594001384 Lipase maturation factor; Region: LMF1; pfam06762 216594001385 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 216594001386 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 216594001387 putative active site [active] 216594001388 catalytic site [active] 216594001389 putative metal binding site [ion binding]; other site 216594001390 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 216594001391 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 216594001392 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 216594001393 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 216594001394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001396 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 216594001397 putative ion selectivity filter; other site 216594001398 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 216594001399 putative pore gating glutamate residue; other site 216594001400 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594001401 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594001402 active site 2 [active] 216594001403 active site 1 [active] 216594001404 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 216594001405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594001406 NAD(P) binding site [chemical binding]; other site 216594001407 active site 216594001408 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 216594001409 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594001410 dimer interface [polypeptide binding]; other site 216594001411 active site 216594001412 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 216594001413 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 216594001414 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 216594001415 FAD binding site [chemical binding]; other site 216594001416 substrate binding site [chemical binding]; other site 216594001417 catalytic residues [active] 216594001418 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216594001419 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 216594001420 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 216594001421 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594001422 catalytic loop [active] 216594001423 iron binding site [ion binding]; other site 216594001424 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 216594001425 L-aspartate oxidase; Provisional; Region: PRK06175 216594001426 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216594001427 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 216594001428 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216594001429 tetramer interface [polypeptide binding]; other site 216594001430 active site 216594001431 Mg2+/Mn2+ binding site [ion binding]; other site 216594001432 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216594001433 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 216594001434 putative dimer interface [polypeptide binding]; other site 216594001435 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 216594001436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594001437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594001438 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216594001439 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216594001440 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 216594001441 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 216594001442 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 216594001443 putative active site [active] 216594001444 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 216594001445 active site 216594001446 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 216594001447 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 216594001448 active site 216594001449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 216594001450 DNA binding site [nucleotide binding] 216594001451 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 216594001452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594001453 Coenzyme A binding pocket [chemical binding]; other site 216594001454 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 216594001455 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 216594001456 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 216594001457 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 216594001458 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 216594001459 intersubunit interface [polypeptide binding]; other site 216594001460 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 216594001461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594001462 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 216594001463 nucleotide binding site [chemical binding]; other site 216594001464 acyl-CoA synthetase; Validated; Region: PRK07788 216594001465 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594001466 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594001467 active site 216594001468 CoA binding site [chemical binding]; other site 216594001469 AMP binding site [chemical binding]; other site 216594001470 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594001471 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594001472 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594001473 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594001474 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 216594001475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594001476 FAD binding site [chemical binding]; other site 216594001477 substrate binding site [chemical binding]; other site 216594001478 catalytic base [active] 216594001479 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216594001480 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 216594001481 putative ligand binding site [chemical binding]; other site 216594001482 putative NAD binding site [chemical binding]; other site 216594001483 catalytic site [active] 216594001484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001486 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 216594001487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594001488 Zn binding site [ion binding]; other site 216594001489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001490 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 216594001491 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001492 PPE family; Region: PPE; pfam00823 216594001493 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594001494 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594001495 ESX-3 216594001496 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 216594001497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594001498 Walker A motif; other site 216594001499 ATP binding site [chemical binding]; other site 216594001500 Walker B motif; other site 216594001501 arginine finger; other site 216594001502 Protein of unknown function (DUF690); Region: DUF690; pfam05108 216594001503 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 216594001504 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594001505 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 216594001506 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594001507 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594001508 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001509 PPE family; Region: PPE; pfam00823 216594001510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 216594001511 EspG family; Region: ESX-1_EspG; pfam14011 216594001512 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 216594001513 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 216594001514 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 216594001515 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 216594001516 active site 216594001517 catalytic residues [active] 216594001518 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 216594001519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594001520 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 216594001521 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 216594001522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594001523 S-adenosylmethionine binding site [chemical binding]; other site 216594001524 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594001525 Sulfatase; Region: Sulfatase; pfam00884 216594001526 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 216594001527 putative FMN binding site [chemical binding]; other site 216594001528 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 216594001529 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216594001530 active site 216594001531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 216594001532 SnoaL-like domain; Region: SnoaL_4; pfam13577 216594001533 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216594001534 nucleotide binding site [chemical binding]; other site 216594001535 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 216594001536 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 216594001537 Prostaglandin dehydrogenases; Region: PGDH; cd05288 216594001538 NAD(P) binding site [chemical binding]; other site 216594001539 substrate binding site [chemical binding]; other site 216594001540 dimer interface [polypeptide binding]; other site 216594001541 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 216594001542 active site 216594001543 catalytic residues [active] 216594001544 Muconolactone delta-isomerase; Region: MIase; cl01992 216594001545 Muconolactone delta-isomerase; Region: MIase; cl01992 216594001546 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216594001547 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 216594001548 active site 216594001549 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 216594001550 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216594001551 nucleotide binding site [chemical binding]; other site 216594001552 MURD7; function unknown but locus contains two CDS with possible roles in carbohydrate modification (phosphorylation and dehydrogenation). Other CDS in this locus encode a PE-PGRS protein and membrane-associated proteins of unknown function 216594001553 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 216594001554 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216594001555 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216594001556 PE family; Region: PE; pfam00934 216594001557 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216594001558 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594001559 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 216594001560 dinuclear metal binding motif [ion binding]; other site 216594001561 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594001562 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594001563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594001564 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594001565 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594001566 substrate binding pocket [chemical binding]; other site 216594001567 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216594001568 2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199 216594001569 active site 216594001570 metal binding site [ion binding]; metal-binding site 216594001571 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216594001572 classical (c) SDRs; Region: SDR_c; cd05233 216594001573 NAD(P) binding site [chemical binding]; other site 216594001574 active site 216594001575 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 216594001576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594001577 active site 216594001578 motif I; other site 216594001579 motif II; other site 216594001580 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216594001581 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216594001582 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 216594001583 NAD(P) binding site [chemical binding]; other site 216594001584 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594001585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594001586 S-adenosylmethionine binding site [chemical binding]; other site 216594001587 Fic family protein [Function unknown]; Region: COG3177 216594001588 Fic/DOC family; Region: Fic; pfam02661 216594001589 bacteriophage phiMmar09; MURD8; Putative prophage, harbours recombinases and an integrase (pseudogene) and has integrated at a glycine tRNA. Other genes encode hypothetical proteins and a dehydrogenase 216594001590 short chain dehydrogenase; Provisional; Region: PRK06500 216594001591 classical (c) SDRs; Region: SDR_c; cd05233 216594001592 NAD(P) binding site [chemical binding]; other site 216594001593 active site 216594001594 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216594001595 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216594001596 catalytic residues [active] 216594001597 catalytic nucleophile [active] 216594001598 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216594001599 Synaptic Flat tetramer interface [polypeptide binding]; other site 216594001600 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216594001601 DNA-binding interface [nucleotide binding]; DNA binding site 216594001602 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 216594001603 ligand binding site [chemical binding]; other site 216594001604 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 216594001605 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216594001606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594001607 putative substrate translocation pore; other site 216594001608 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 216594001609 putative substrate binding pocket [chemical binding]; other site 216594001610 AC domain interface; other site 216594001611 catalytic triad [active] 216594001612 AB domain interface; other site 216594001613 interchain disulfide; other site 216594001614 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216594001615 trimer interface [polypeptide binding]; other site 216594001616 active site 216594001617 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 216594001618 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216594001619 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216594001620 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 216594001621 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 216594001622 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594001623 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 216594001624 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 216594001625 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 216594001626 substrate binding site; other site 216594001627 tetramer interface; other site 216594001628 PE family; Region: PE; pfam00934 216594001629 PE family; Region: PE; pfam00934 216594001630 PE family; Region: PE; pfam00934 216594001631 aminotransferase AlaT; Validated; Region: PRK09265 216594001632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594001633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594001634 homodimer interface [polypeptide binding]; other site 216594001635 catalytic residue [active] 216594001636 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 216594001637 4Fe-4S binding domain; Region: Fer4; pfam00037 216594001638 Cysteine-rich domain; Region: CCG; pfam02754 216594001639 Cysteine-rich domain; Region: CCG; pfam02754 216594001640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594001641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594001642 DNA binding residues [nucleotide binding] 216594001643 dimerization interface [polypeptide binding]; other site 216594001644 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 216594001645 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 216594001646 G1 box; other site 216594001647 GTP/Mg2+ binding site [chemical binding]; other site 216594001648 G2 box; other site 216594001649 Switch I region; other site 216594001650 G3 box; other site 216594001651 Switch II region; other site 216594001652 G4 box; other site 216594001653 G5 box; other site 216594001654 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 216594001655 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 216594001656 G1 box; other site 216594001657 GTP/Mg2+ binding site [chemical binding]; other site 216594001658 G2 box; other site 216594001659 Switch I region; other site 216594001660 G3 box; other site 216594001661 Switch II region; other site 216594001662 G4 box; other site 216594001663 G5 box; other site 216594001664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216594001665 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216594001666 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594001667 catalytic loop [active] 216594001668 iron binding site [ion binding]; other site 216594001669 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216594001670 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 216594001671 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 216594001672 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216594001673 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 216594001674 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216594001675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216594001676 PE family; Region: PE; pfam00934 216594001677 L-asparagine permease; Provisional; Region: PRK15049 216594001678 MURD9; Probable potassium transport locus, contains genes encoding the KdpFABC complex. Also contains KdpD/E, the two-component regulator of the Kdp operon 216594001679 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 216594001680 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216594001681 classical (c) SDRs; Region: SDR_c; cd05233 216594001682 NAD(P) binding site [chemical binding]; other site 216594001683 active site 216594001684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001686 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 216594001687 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 216594001688 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594001689 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594001690 K+-transporting ATPase, c chain; Region: KdpC; cl00944 216594001691 K+-transporting ATPase, c chain; Region: KdpC; cl00944 216594001692 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 216594001693 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 216594001694 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 216594001695 Ligand Binding Site [chemical binding]; other site 216594001696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594001697 dimer interface [polypeptide binding]; other site 216594001698 phosphorylation site [posttranslational modification] 216594001699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594001700 ATP binding site [chemical binding]; other site 216594001701 Mg2+ binding site [ion binding]; other site 216594001702 G-X-G motif; other site 216594001703 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 216594001704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594001705 active site 216594001706 phosphorylation site [posttranslational modification] 216594001707 intermolecular recognition site; other site 216594001708 dimerization interface [polypeptide binding]; other site 216594001709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594001710 DNA binding site [nucleotide binding] 216594001711 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 216594001712 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 216594001713 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 216594001714 nucleotide binding site [chemical binding]; other site 216594001715 NEF interaction site [polypeptide binding]; other site 216594001716 SBD interface [polypeptide binding]; other site 216594001717 GrpE; Region: GrpE; pfam01025 216594001718 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 216594001719 dimer interface [polypeptide binding]; other site 216594001720 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 216594001721 chaperone protein DnaJ; Provisional; Region: PRK14279 216594001722 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216594001723 HSP70 interaction site [polypeptide binding]; other site 216594001724 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216594001725 Zn binding sites [ion binding]; other site 216594001726 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 216594001727 dimer interface [polypeptide binding]; other site 216594001728 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 216594001729 DNA binding residues [nucleotide binding] 216594001730 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216594001731 putative dimer interface [polypeptide binding]; other site 216594001732 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001733 PPE family; Region: PPE; pfam00823 216594001734 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001735 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001736 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001737 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001738 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001739 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001740 MURD10; This region covers two very large PPE genes only 216594001741 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001742 PPE family; Region: PPE; pfam00823 216594001743 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001744 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001745 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001746 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001747 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001748 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001749 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001750 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001751 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001752 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594001753 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001754 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001755 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 216594001756 active site 216594001757 catalytic residues [active] 216594001758 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 216594001759 heme-binding site [chemical binding]; other site 216594001760 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 216594001761 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 216594001762 FAD binding pocket [chemical binding]; other site 216594001763 FAD binding motif [chemical binding]; other site 216594001764 phosphate binding motif [ion binding]; other site 216594001765 beta-alpha-beta structure motif; other site 216594001766 NAD binding pocket [chemical binding]; other site 216594001767 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 216594001768 Clp amino terminal domain; Region: Clp_N; pfam02861 216594001769 Clp amino terminal domain; Region: Clp_N; pfam02861 216594001770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594001771 Walker A motif; other site 216594001772 ATP binding site [chemical binding]; other site 216594001773 Walker B motif; other site 216594001774 arginine finger; other site 216594001775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594001776 Walker A motif; other site 216594001777 ATP binding site [chemical binding]; other site 216594001778 Walker B motif; other site 216594001779 arginine finger; other site 216594001780 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216594001781 enoyl-CoA hydratase; Provisional; Region: PRK07658 216594001782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594001783 substrate binding site [chemical binding]; other site 216594001784 oxyanion hole (OAH) forming residues; other site 216594001785 trimer interface [polypeptide binding]; other site 216594001786 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216594001787 classical (c) SDRs; Region: SDR_c; cd05233 216594001788 NAD(P) binding site [chemical binding]; other site 216594001789 active site 216594001790 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216594001791 active site 216594001792 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216594001793 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216594001794 Uncharacterized conserved protein [Function unknown]; Region: COG3360 216594001795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216594001796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216594001797 LysR substrate binding domain; Region: LysR_substrate; pfam03466 216594001798 dimerization interface [polypeptide binding]; other site 216594001799 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216594001800 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216594001801 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 216594001802 XdhC Rossmann domain; Region: XdhC_C; pfam13478 216594001803 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 216594001804 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 216594001805 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216594001806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594001807 catalytic loop [active] 216594001808 iron binding site [ion binding]; other site 216594001809 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216594001810 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 216594001811 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 216594001812 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216594001813 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 216594001814 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216594001815 XdhC Rossmann domain; Region: XdhC_C; pfam13478 216594001816 metallochaperone-like domain; Region: TRASH; smart00746 216594001817 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 216594001818 Ligand binding site; other site 216594001819 metal-binding site 216594001820 MoxR-like ATPases [General function prediction only]; Region: COG0714 216594001821 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 216594001822 putative hydrophobic ligand binding site [chemical binding]; other site 216594001823 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 216594001824 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 216594001825 metal ion-dependent adhesion site (MIDAS); other site 216594001826 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 216594001827 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 216594001828 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 216594001829 ethanolamine permease; Region: 2A0305; TIGR00908 216594001830 Heme NO binding associated; Region: HNOBA; pfam07701 216594001831 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 216594001832 cyclase homology domain; Region: CHD; cd07302 216594001833 nucleotidyl binding site; other site 216594001834 metal binding site [ion binding]; metal-binding site 216594001835 dimer interface [polypeptide binding]; other site 216594001836 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 216594001837 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216594001838 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216594001839 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 216594001840 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 216594001841 active site 216594001842 intersubunit interface [polypeptide binding]; other site 216594001843 zinc binding site [ion binding]; other site 216594001844 Na+ binding site [ion binding]; other site 216594001845 MgtE intracellular N domain; Region: MgtE_N; cl15244 216594001846 FOG: CBS domain [General function prediction only]; Region: COG0517 216594001847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 216594001848 Divalent cation transporter; Region: MgtE; pfam01769 216594001849 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 216594001850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594001851 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 216594001852 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 216594001853 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 216594001854 Peptidase family M50; Region: Peptidase_M50; pfam02163 216594001855 active site 216594001856 putative substrate binding region [chemical binding]; other site 216594001857 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 216594001858 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 216594001859 GDP-binding site [chemical binding]; other site 216594001860 ACT binding site; other site 216594001861 IMP binding site; other site 216594001862 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594001863 CoenzymeA binding site [chemical binding]; other site 216594001864 subunit interaction site [polypeptide binding]; other site 216594001865 PHB binding site; other site 216594001866 MURD11; function Unknown but several genes in this region appear to me involved in amino acid metabolism. For example, aspartate decarboxylase (beta-alanine production) and gamma-butyrobetaine hydroxylase. Another amino acid metabolism candidates in this MURD is metZ (methionine biosynthesis). There is also a an orthologue of purT (purine biosynthesis) and ndh (electron transfer from NADH to ubiquinone. Other genes include a putative beta- lactamase, and a hypothetical secreted protein 216594001867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594001868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594001869 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594001870 PPE family; Region: PPE; pfam00823 216594001871 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 216594001872 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216594001873 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 216594001874 active site residue [active] 216594001875 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 216594001876 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216594001877 homodimer interface [polypeptide binding]; other site 216594001878 substrate-cofactor binding pocket; other site 216594001879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594001880 catalytic residue [active] 216594001881 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 216594001882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594001883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594001884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594001885 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 216594001886 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 216594001887 Protein of unknown function (DUF971); Region: DUF971; cl01414 216594001888 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 216594001889 substrate binding pocket [chemical binding]; other site 216594001890 active site 216594001891 iron coordination sites [ion binding]; other site 216594001892 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 216594001893 tetramerization interface [polypeptide binding]; other site 216594001894 active site 216594001895 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594001896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594001897 S-adenosylmethionine binding site [chemical binding]; other site 216594001898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594001899 S-adenosylmethionine binding site [chemical binding]; other site 216594001900 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594001901 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594001902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594001903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594001904 active site 216594001905 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594001906 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594001907 active site 216594001908 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 216594001909 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594001910 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 216594001911 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 216594001912 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 216594001913 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216594001914 active site 216594001915 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216594001916 non-prolyl cis peptide bond; other site 216594001917 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594001918 MURD12; Function unknown but contains an MmpL gene, FAAL and PKS gene that are probaboly involved in the production and ligation of an apolar diketide (Pks6) to another lipid followed by export 216594001919 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594001920 acyl-CoA synthetase; Validated; Region: PRK05850 216594001921 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594001922 acyl-activating enzyme (AAE) consensus motif; other site 216594001923 active site 216594001924 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594001925 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594001926 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 216594001927 active site 216594001928 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594001929 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594001930 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594001931 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594001932 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 216594001933 active site 216594001934 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594001935 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594001936 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594001937 Thioesterase; Region: PKS_TE; smart00824 216594001938 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594001939 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 216594001940 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 216594001941 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594001942 phosphate acetyltransferase; Reviewed; Region: PRK05632 216594001943 DRTGG domain; Region: DRTGG; pfam07085 216594001944 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 216594001945 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 216594001946 propionate/acetate kinase; Provisional; Region: PRK12379 216594001947 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 216594001948 putative active site [active] 216594001949 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594001950 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594001951 active site 216594001952 ATP binding site [chemical binding]; other site 216594001953 substrate binding site [chemical binding]; other site 216594001954 activation loop (A-loop); other site 216594001955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216594001956 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216594001957 substrate binding pocket [chemical binding]; other site 216594001958 membrane-bound complex binding site; other site 216594001959 hinge residues; other site 216594001960 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 216594001961 nudix motif; other site 216594001962 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 216594001963 thiamine phosphate binding site [chemical binding]; other site 216594001964 active site 216594001965 pyrophosphate binding site [ion binding]; other site 216594001966 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594001967 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 216594001968 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 216594001969 thiS-thiF/thiG interaction site; other site 216594001970 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 216594001971 ThiS interaction site; other site 216594001972 putative active site [active] 216594001973 tetramer interface [polypeptide binding]; other site 216594001974 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 216594001975 active site 216594001976 catalytic triad [active] 216594001977 oxyanion hole [active] 216594001978 Interferon-induced transmembrane protein; Region: CD225; pfam04505 216594001979 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 216594001980 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 216594001981 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 216594001982 PA/protease or protease-like domain interface [polypeptide binding]; other site 216594001983 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 216594001984 Peptidase family M28; Region: Peptidase_M28; pfam04389 216594001985 active site 216594001986 metal binding site [ion binding]; metal-binding site 216594001987 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 216594001988 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 216594001989 PA/protease or protease-like domain interface [polypeptide binding]; other site 216594001990 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 216594001991 Peptidase family M28; Region: Peptidase_M28; pfam04389 216594001992 active site 216594001993 metal binding site [ion binding]; metal-binding site 216594001994 Predicted metalloprotease [General function prediction only]; Region: COG2321 216594001995 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 216594001996 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594001997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594001998 putative substrate translocation pore; other site 216594001999 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594002000 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594002001 ligand binding site [chemical binding]; other site 216594002002 flexible hinge region; other site 216594002003 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216594002004 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 216594002005 active site 216594002006 nucleophile elbow; other site 216594002007 Response regulator receiver domain; Region: Response_reg; pfam00072 216594002008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594002009 active site 216594002010 phosphorylation site [posttranslational modification] 216594002011 intermolecular recognition site; other site 216594002012 dimerization interface [polypeptide binding]; other site 216594002013 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594002014 cyclase homology domain; Region: CHD; cd07302 216594002015 nucleotidyl binding site; other site 216594002016 metal binding site [ion binding]; metal-binding site 216594002017 dimer interface [polypeptide binding]; other site 216594002018 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594002019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002023 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216594002024 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 216594002025 dimer interface [polypeptide binding]; other site 216594002026 substrate binding site [chemical binding]; other site 216594002027 ATP binding site [chemical binding]; other site 216594002028 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 216594002029 ThiC-associated domain; Region: ThiC-associated; pfam13667 216594002030 ThiC family; Region: ThiC; pfam01964 216594002031 PAS fold; Region: PAS_3; pfam08447 216594002032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216594002033 putative active site [active] 216594002034 heme pocket [chemical binding]; other site 216594002035 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 216594002036 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216594002037 anti sigma factor interaction site; other site 216594002038 regulatory phosphorylation site [posttranslational modification]; other site 216594002039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216594002040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594002041 dimer interface [polypeptide binding]; other site 216594002042 phosphorylation site [posttranslational modification] 216594002043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594002044 ATP binding site [chemical binding]; other site 216594002045 Mg2+ binding site [ion binding]; other site 216594002046 G-X-G motif; other site 216594002047 Response regulator receiver domain; Region: Response_reg; pfam00072 216594002048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594002049 active site 216594002050 phosphorylation site [posttranslational modification] 216594002051 intermolecular recognition site; other site 216594002052 dimerization interface [polypeptide binding]; other site 216594002053 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216594002054 GAF domain; Region: GAF_2; pfam13185 216594002055 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 216594002056 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 216594002057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594002058 ATP binding site [chemical binding]; other site 216594002059 Mg2+ binding site [ion binding]; other site 216594002060 G-X-G motif; other site 216594002061 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216594002062 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 216594002063 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594002064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594002065 motif II; other site 216594002066 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216594002067 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 216594002068 putative catalytic site [active] 216594002069 putative phosphate binding site [ion binding]; other site 216594002070 active site 216594002071 metal binding site A [ion binding]; metal-binding site 216594002072 DNA binding site [nucleotide binding] 216594002073 putative AP binding site [nucleotide binding]; other site 216594002074 putative metal binding site B [ion binding]; other site 216594002075 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 216594002076 active site 216594002077 catalytic residues [active] 216594002078 metal binding site [ion binding]; metal-binding site 216594002079 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 216594002080 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 216594002081 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 216594002082 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 216594002083 E-class dimer interface [polypeptide binding]; other site 216594002084 P-class dimer interface [polypeptide binding]; other site 216594002085 active site 216594002086 Cu2+ binding site [ion binding]; other site 216594002087 Zn2+ binding site [ion binding]; other site 216594002088 carboxylate-amine ligase; Provisional; Region: PRK13517 216594002089 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 216594002090 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216594002091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594002092 DNA-binding site [nucleotide binding]; DNA binding site 216594002093 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216594002094 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 216594002095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594002096 putative substrate translocation pore; other site 216594002097 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 216594002098 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 216594002099 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 216594002100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594002101 Walker A motif; other site 216594002102 ATP binding site [chemical binding]; other site 216594002103 Walker B motif; other site 216594002104 arginine finger; other site 216594002105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594002106 Walker A motif; other site 216594002107 ATP binding site [chemical binding]; other site 216594002108 Walker B motif; other site 216594002109 arginine finger; other site 216594002110 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 216594002111 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 216594002112 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 216594002113 PE family; Region: PE; pfam00934 216594002114 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 216594002115 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 216594002116 dimer interface [polypeptide binding]; other site 216594002117 putative functional site; other site 216594002118 putative MPT binding site; other site 216594002119 short chain dehydrogenase; Provisional; Region: PRK06197 216594002120 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 216594002121 putative NAD(P) binding site [chemical binding]; other site 216594002122 active site 216594002123 Cupin domain; Region: Cupin_2; pfam07883 216594002124 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 216594002125 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216594002126 ring oligomerisation interface [polypeptide binding]; other site 216594002127 ATP/Mg binding site [chemical binding]; other site 216594002128 stacking interactions; other site 216594002129 hinge regions; other site 216594002130 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594002131 PPE family; Region: PPE; pfam00823 216594002132 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 216594002133 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 216594002134 active site 216594002135 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594002136 Protein of unknown function (DUF664); Region: DUF664; pfam04978 216594002137 DinB superfamily; Region: DinB_2; pfam12867 216594002138 Anti-sigma-K factor rskA; Region: RskA; pfam10099 216594002139 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 216594002140 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594002141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594002142 DNA binding residues [nucleotide binding] 216594002143 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 216594002144 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594002145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002146 S-adenosylmethionine binding site [chemical binding]; other site 216594002147 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 216594002148 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 216594002149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594002150 Transport protein; Region: actII; TIGR00833 216594002151 MURD13; Contains two MmpL loci and a putative regulator 216594002152 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594002153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002155 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594002156 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594002157 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 216594002158 enoyl-CoA hydratase; Provisional; Region: PRK12478 216594002159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594002160 substrate binding site [chemical binding]; other site 216594002161 oxyanion hole (OAH) forming residues; other site 216594002162 trimer interface [polypeptide binding]; other site 216594002163 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 216594002164 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594002165 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216594002166 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594002167 NAD(P) binding site [chemical binding]; other site 216594002168 catalytic residues [active] 216594002169 Protein of unknown function (DUF779); Region: DUF779; pfam05610 216594002170 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216594002171 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594002172 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594002173 catalytic residue [active] 216594002174 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 216594002175 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 216594002176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594002177 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216594002178 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594002179 PPE family; Region: PPE; pfam00823 216594002180 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216594002181 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216594002182 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216594002183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594002184 non-specific DNA binding site [nucleotide binding]; other site 216594002185 salt bridge; other site 216594002186 sequence-specific DNA binding site [nucleotide binding]; other site 216594002187 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 216594002188 Domain of unknown function (DUF955); Region: DUF955; pfam06114 216594002189 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 216594002190 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 216594002191 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594002192 active site 2 [active] 216594002193 active site 1 [active] 216594002194 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594002195 active site 2 [active] 216594002196 isocitrate lyase; Provisional; Region: PRK15063 216594002197 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216594002198 tetramer interface [polypeptide binding]; other site 216594002199 active site 216594002200 Mg2+/Mn2+ binding site [ion binding]; other site 216594002201 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 216594002202 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216594002203 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216594002204 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594002205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594002206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002207 S-adenosylmethionine binding site [chemical binding]; other site 216594002208 MURD14; Insertion sequence ISMyma04 216594002209 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 216594002210 Winged helix-turn helix; Region: HTH_29; pfam13551 216594002211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216594002212 Integrase core domain; Region: rve; pfam00665 216594002213 Integrase core domain; Region: rve_3; pfam13683 216594002214 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594002215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002216 S-adenosylmethionine binding site [chemical binding]; other site 216594002217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002219 Predicted membrane protein [Function unknown]; Region: COG2733 216594002220 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216594002221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594002222 non-specific DNA binding site [nucleotide binding]; other site 216594002223 salt bridge; other site 216594002224 sequence-specific DNA binding site [nucleotide binding]; other site 216594002225 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 216594002226 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 216594002227 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 216594002228 intersubunit interface [polypeptide binding]; other site 216594002229 active site 216594002230 catalytic residue [active] 216594002231 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 216594002232 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216594002233 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 216594002234 putative active site [active] 216594002235 catalytic triad [active] 216594002236 putative dimer interface [polypeptide binding]; other site 216594002237 PE family; Region: PE; pfam00934 216594002238 MURD15; Spans a large PE-PGRS family protein 216594002239 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 216594002240 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 216594002241 FAD binding domain; Region: FAD_binding_4; pfam01565 216594002242 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 216594002243 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 216594002244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216594002245 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 216594002246 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216594002247 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216594002248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594002249 NAD(P) binding site [chemical binding]; other site 216594002250 active site 216594002251 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216594002252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216594002253 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 216594002254 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 216594002255 putative ADP-binding pocket [chemical binding]; other site 216594002256 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 216594002257 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594002258 catalytic core [active] 216594002259 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594002260 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216594002261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594002262 dimer interface [polypeptide binding]; other site 216594002263 phosphorylation site [posttranslational modification] 216594002264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594002265 ATP binding site [chemical binding]; other site 216594002266 Mg2+ binding site [ion binding]; other site 216594002267 G-X-G motif; other site 216594002268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594002269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594002270 active site 216594002271 phosphorylation site [posttranslational modification] 216594002272 intermolecular recognition site; other site 216594002273 dimerization interface [polypeptide binding]; other site 216594002274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594002275 DNA binding site [nucleotide binding] 216594002276 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 216594002277 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 216594002278 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594002279 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216594002280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594002281 DNA-binding site [nucleotide binding]; DNA binding site 216594002282 FCD domain; Region: FCD; cl11656 216594002283 exopolyphosphatase; Region: exo_poly_only; TIGR03706 216594002284 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 216594002285 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216594002286 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 216594002287 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 216594002288 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 216594002289 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 216594002290 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 216594002291 DNA binding domain, excisionase family; Region: excise; TIGR01764 216594002292 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216594002293 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 216594002294 putative NAD(P) binding site [chemical binding]; other site 216594002295 active site 216594002296 putative substrate binding site [chemical binding]; other site 216594002297 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594002298 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 216594002299 putative acyl-acceptor binding pocket; other site 216594002300 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594002301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594002302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002303 S-adenosylmethionine binding site [chemical binding]; other site 216594002304 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 216594002305 active site 216594002306 catalytic site [active] 216594002307 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216594002308 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 216594002309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594002310 active site 216594002311 motif I; other site 216594002312 motif II; other site 216594002313 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216594002314 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594002315 catalytic loop [active] 216594002316 iron binding site [ion binding]; other site 216594002317 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216594002318 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 216594002319 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 216594002320 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216594002321 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 216594002322 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216594002323 PE family; Region: PE; pfam00934 216594002324 MURD16; May have a role in lipid transport as it spans a 2- CDS MmpL locus 216594002325 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594002326 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594002327 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 216594002328 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 216594002329 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 216594002330 tRNA; other site 216594002331 putative tRNA binding site [nucleotide binding]; other site 216594002332 putative NADP binding site [chemical binding]; other site 216594002333 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 216594002334 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 216594002335 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 216594002336 domain interfaces; other site 216594002337 active site 216594002338 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 216594002339 active site 216594002340 homodimer interface [polypeptide binding]; other site 216594002341 SAM binding site [chemical binding]; other site 216594002342 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 216594002343 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 216594002344 active site 216594002345 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 216594002346 dimer interface [polypeptide binding]; other site 216594002347 active site 216594002348 Schiff base residues; other site 216594002349 MURD17; Function unknown but contains a large ORF encoding a NRP with predicted synthesis of an 8 amino acid metabolite 216594002350 Condensation domain; Region: Condensation; pfam00668 216594002351 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594002352 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594002353 acyl-activating enzyme (AAE) consensus motif; other site 216594002354 AMP binding site [chemical binding]; other site 216594002355 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594002356 Condensation domain; Region: Condensation; pfam00668 216594002357 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594002358 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594002359 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594002360 acyl-activating enzyme (AAE) consensus motif; other site 216594002361 AMP binding site [chemical binding]; other site 216594002362 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594002363 Condensation domain; Region: Condensation; pfam00668 216594002364 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594002365 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594002366 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594002367 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594002368 acyl-activating enzyme (AAE) consensus motif; other site 216594002369 AMP binding site [chemical binding]; other site 216594002370 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594002371 Condensation domain; Region: Condensation; pfam00668 216594002372 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594002373 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594002374 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594002375 acyl-activating enzyme (AAE) consensus motif; other site 216594002376 AMP binding site [chemical binding]; other site 216594002377 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594002378 Condensation domain; Region: Condensation; pfam00668 216594002379 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594002380 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594002381 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594002382 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594002383 acyl-activating enzyme (AAE) consensus motif; other site 216594002384 AMP binding site [chemical binding]; other site 216594002385 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594002386 Condensation domain; Region: Condensation; pfam00668 216594002387 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594002388 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594002389 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594002390 acyl-activating enzyme (AAE) consensus motif; other site 216594002391 AMP binding site [chemical binding]; other site 216594002392 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594002393 Condensation domain; Region: Condensation; pfam00668 216594002394 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594002395 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594002396 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594002397 acyl-activating enzyme (AAE) consensus motif; other site 216594002398 AMP binding site [chemical binding]; other site 216594002399 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594002400 Condensation domain; Region: Condensation; pfam00668 216594002401 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594002402 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594002403 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594002404 acyl-activating enzyme (AAE) consensus motif; other site 216594002405 AMP binding site [chemical binding]; other site 216594002406 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594002407 Cytochrome P450; Region: p450; cl12078 216594002408 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594002409 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216594002410 anti sigma factor interaction site; other site 216594002411 regulatory phosphorylation site [posttranslational modification]; other site 216594002412 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216594002413 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 216594002414 active site 216594002415 catalytic triad [active] 216594002416 oxyanion hole [active] 216594002417 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216594002418 Putative esterase; Region: Esterase; pfam00756 216594002419 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594002420 Ligand Binding Site [chemical binding]; other site 216594002421 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 216594002422 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 216594002423 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594002424 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 216594002425 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594002426 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216594002427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002428 S-adenosylmethionine binding site [chemical binding]; other site 216594002429 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594002430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002431 S-adenosylmethionine binding site [chemical binding]; other site 216594002432 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 216594002433 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 216594002434 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 216594002435 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 216594002436 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216594002437 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 216594002438 metal binding site [ion binding]; metal-binding site 216594002439 substrate binding pocket [chemical binding]; other site 216594002440 Domain of unknown function (DUF427); Region: DUF427; pfam04248 216594002441 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216594002442 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594002443 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594002444 active site 216594002445 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216594002446 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 216594002447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594002448 inhibitor-cofactor binding pocket; inhibition site 216594002449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594002450 catalytic residue [active] 216594002451 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 216594002452 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216594002453 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216594002454 catalytic residues [active] 216594002455 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 216594002456 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 216594002457 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 216594002458 ResB-like family; Region: ResB; pfam05140 216594002459 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 216594002460 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216594002461 AAA domain; Region: AAA_31; pfam13614 216594002462 P-loop; other site 216594002463 Magnesium ion binding site [ion binding]; other site 216594002464 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216594002465 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216594002466 dimer interface [polypeptide binding]; other site 216594002467 active site 216594002468 CoA binding pocket [chemical binding]; other site 216594002469 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 216594002470 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 216594002471 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216594002472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594002473 NAD(P) binding site [chemical binding]; other site 216594002474 active site 216594002475 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 216594002476 Ligand binding site; other site 216594002477 Putative Catalytic site; other site 216594002478 DXD motif; other site 216594002479 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 216594002480 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 216594002481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594002482 acyl-activating enzyme (AAE) consensus motif; other site 216594002483 AMP binding site [chemical binding]; other site 216594002484 active site 216594002485 CoA binding site [chemical binding]; other site 216594002486 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 216594002487 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216594002488 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594002489 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216594002490 active site 216594002491 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594002492 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 216594002493 short chain dehydrogenase; Provisional; Region: PRK05866 216594002494 classical (c) SDRs; Region: SDR_c; cd05233 216594002495 NAD(P) binding site [chemical binding]; other site 216594002496 active site 216594002497 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594002498 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 216594002499 substrate binding site [chemical binding]; other site 216594002500 oxyanion hole (OAH) forming residues; other site 216594002501 trimer interface [polypeptide binding]; other site 216594002502 acyl-CoA synthetase; Validated; Region: PRK06188 216594002503 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594002504 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 216594002505 putative active site [active] 216594002506 putative CoA binding site [chemical binding]; other site 216594002507 putative AMP binding site [chemical binding]; other site 216594002508 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 216594002509 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 216594002510 active site 216594002511 O-succinylbenzoate synthase; Provisional; Region: PRK02901 216594002512 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 216594002513 metal binding site [ion binding]; metal-binding site 216594002514 substrate binding pocket [chemical binding]; other site 216594002515 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594002516 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 216594002517 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594002518 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 216594002519 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 216594002520 dimer interface [polypeptide binding]; other site 216594002521 tetramer interface [polypeptide binding]; other site 216594002522 PYR/PP interface [polypeptide binding]; other site 216594002523 TPP binding site [chemical binding]; other site 216594002524 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 216594002525 TPP-binding site; other site 216594002526 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 216594002527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594002528 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 216594002529 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216594002530 MarR family; Region: MarR; pfam01047 216594002531 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 216594002532 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 216594002533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002534 S-adenosylmethionine binding site [chemical binding]; other site 216594002535 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594002536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002537 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 216594002538 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594002539 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216594002540 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216594002541 substrate binding pocket [chemical binding]; other site 216594002542 chain length determination region; other site 216594002543 substrate-Mg2+ binding site; other site 216594002544 catalytic residues [active] 216594002545 aspartate-rich region 1; other site 216594002546 active site lid residues [active] 216594002547 aspartate-rich region 2; other site 216594002548 heat shock protein HtpX; Provisional; Region: PRK03072 216594002549 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216594002550 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 216594002551 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216594002552 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216594002553 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216594002554 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 216594002555 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 216594002556 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 216594002557 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216594002558 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 216594002559 TPR repeat; Region: TPR_11; pfam13414 216594002560 Tetratricopeptide repeat; Region: TPR_2; pfam07719 216594002561 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 216594002562 Double zinc ribbon; Region: DZR; pfam12773 216594002563 MURD18; Contains an ORF encoding a flavoprotein with a predicted role in K+ transport and the 3' end of an ORF encoding a putative trypsin-like serine protease 216594002564 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594002565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594002566 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 216594002567 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 216594002568 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 216594002569 active site 216594002570 zinc binding site [ion binding]; other site 216594002571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216594002572 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216594002573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 216594002574 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 216594002575 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216594002576 FtsX-like permease family; Region: FtsX; pfam02687 216594002577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216594002578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216594002579 Walker A/P-loop; other site 216594002580 ATP binding site [chemical binding]; other site 216594002581 Q-loop/lid; other site 216594002582 ABC transporter signature motif; other site 216594002583 Walker B; other site 216594002584 D-loop; other site 216594002585 H-loop/switch region; other site 216594002586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002588 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 216594002589 classical (c) SDRs; Region: SDR_c; cd05233 216594002590 NAD(P) binding site [chemical binding]; other site 216594002591 active site 216594002592 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 216594002593 MURD19; Contains a single gene encoding a PPE family protein 216594002594 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594002595 PPE family; Region: PPE; pfam00823 216594002596 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594002597 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594002598 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594002599 Cytochrome P450; Region: p450; cl12078 216594002600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002602 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 216594002603 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 216594002604 DNA binding site [nucleotide binding] 216594002605 MURD20; Contains a PPE family protein 216594002606 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594002607 PPE family; Region: PPE; pfam00823 216594002608 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594002609 O-methyltransferase; Region: Methyltransf_2; pfam00891 216594002610 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594002611 cyclase homology domain; Region: CHD; cd07302 216594002612 nucleotidyl binding site; other site 216594002613 metal binding site [ion binding]; metal-binding site 216594002614 dimer interface [polypeptide binding]; other site 216594002615 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594002616 Sulfatase; Region: Sulfatase; pfam00884 216594002617 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 216594002618 amidase; Provisional; Region: PRK08137 216594002619 Amidase; Region: Amidase; cl11426 216594002620 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594002621 Cytochrome P450; Region: p450; cl12078 216594002622 MURD21; Contains a cypP450 gene 216594002623 hypothetical protein; Provisional; Region: PRK07588 216594002624 hypothetical protein; Provisional; Region: PRK07236 216594002625 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594002626 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 216594002627 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 216594002628 nucleotide binding site/active site [active] 216594002629 HIT family signature motif; other site 216594002630 catalytic residue [active] 216594002631 galactokinase; Provisional; Region: PRK00555 216594002632 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 216594002633 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 216594002634 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 216594002635 putative hydrophobic ligand binding site [chemical binding]; other site 216594002636 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594002637 TIGR03086 family protein; Region: TIGR03086 216594002638 PE family; Region: PE; pfam00934 216594002639 Predicted membrane protein [Function unknown]; Region: COG1289 216594002640 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 216594002641 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 216594002642 Uncharacterized conserved protein [Function unknown]; Region: COG1656 216594002643 Protein of unknown function DUF82; Region: DUF82; pfam01927 216594002644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594002645 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594002646 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594002647 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216594002648 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216594002649 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216594002650 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 216594002651 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 216594002652 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 216594002653 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 216594002654 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 216594002655 Amidohydrolase; Region: Amidohydro_4; pfam13147 216594002656 active site 216594002657 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594002658 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594002659 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 216594002660 AAA domain; Region: AAA_30; pfam13604 216594002661 Family description; Region: UvrD_C_2; pfam13538 216594002662 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 216594002663 Part of AAA domain; Region: AAA_19; pfam13245 216594002664 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 216594002665 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 216594002666 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 216594002667 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 216594002668 putative FMN binding site [chemical binding]; other site 216594002669 cyanate hydratase; Validated; Region: PRK02866 216594002670 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 216594002671 oligomer interface [polypeptide binding]; other site 216594002672 active site 216594002673 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216594002674 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 216594002675 active site 216594002676 nucleophile elbow; other site 216594002677 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 216594002678 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594002679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594002680 substrate binding site [chemical binding]; other site 216594002681 oxyanion hole (OAH) forming residues; other site 216594002682 trimer interface [polypeptide binding]; other site 216594002683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216594002684 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 216594002685 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 216594002686 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 216594002687 active site 216594002688 catalytic site [active] 216594002689 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 216594002690 active site 216594002691 catalytic site [active] 216594002692 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 216594002693 active site 216594002694 catalytic site [active] 216594002695 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 216594002696 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 216594002697 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 216594002698 putative homodimer interface [polypeptide binding]; other site 216594002699 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 216594002700 heterodimer interface [polypeptide binding]; other site 216594002701 homodimer interface [polypeptide binding]; other site 216594002702 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 216594002703 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 216594002704 23S rRNA interface [nucleotide binding]; other site 216594002705 L7/L12 interface [polypeptide binding]; other site 216594002706 putative thiostrepton binding site; other site 216594002707 L25 interface [polypeptide binding]; other site 216594002708 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 216594002709 mRNA/rRNA interface [nucleotide binding]; other site 216594002710 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 216594002711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594002712 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216594002713 DNA binding residues [nucleotide binding] 216594002714 YCII-related domain; Region: YCII; cl00999 216594002715 YCII-related domain; Region: YCII; cl00999 216594002716 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594002717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002718 S-adenosylmethionine binding site [chemical binding]; other site 216594002719 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594002720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594002721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002722 S-adenosylmethionine binding site [chemical binding]; other site 216594002723 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594002724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594002725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002726 S-adenosylmethionine binding site [chemical binding]; other site 216594002727 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594002728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002729 S-adenosylmethionine binding site [chemical binding]; other site 216594002730 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594002731 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 216594002732 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216594002733 active site 216594002734 ATP binding site [chemical binding]; other site 216594002735 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 216594002736 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 216594002737 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594002738 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 216594002739 Amidase; Region: Amidase; pfam01425 216594002740 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 216594002741 active site 216594002742 catalytic site [active] 216594002743 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 216594002744 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 216594002745 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 216594002746 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216594002747 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216594002748 nucleotide binding site [chemical binding]; other site 216594002749 MURD22; Probable insertion sequence 216594002750 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 216594002751 Winged helix-turn helix; Region: HTH_29; pfam13551 216594002752 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216594002753 Integrase core domain; Region: rve; pfam00665 216594002754 Integrase core domain; Region: rve_3; pfam13683 216594002755 PE family; Region: PE; pfam00934 216594002756 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 216594002757 23S rRNA interface [nucleotide binding]; other site 216594002758 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 216594002759 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 216594002760 core dimer interface [polypeptide binding]; other site 216594002761 peripheral dimer interface [polypeptide binding]; other site 216594002762 L10 interface [polypeptide binding]; other site 216594002763 L11 interface [polypeptide binding]; other site 216594002764 putative EF-Tu interaction site [polypeptide binding]; other site 216594002765 putative EF-G interaction site [polypeptide binding]; other site 216594002766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002768 WHG domain; Region: WHG; pfam13305 216594002769 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 216594002770 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 216594002771 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 216594002772 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 216594002773 Walker A/P-loop; other site 216594002774 ATP binding site [chemical binding]; other site 216594002775 Q-loop/lid; other site 216594002776 ABC transporter signature motif; other site 216594002777 Walker B; other site 216594002778 D-loop; other site 216594002779 H-loop/switch region; other site 216594002780 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 216594002781 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 216594002782 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216594002783 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216594002784 RPB10 interaction site [polypeptide binding]; other site 216594002785 RPB1 interaction site [polypeptide binding]; other site 216594002786 RPB11 interaction site [polypeptide binding]; other site 216594002787 RPB3 interaction site [polypeptide binding]; other site 216594002788 RPB12 interaction site [polypeptide binding]; other site 216594002789 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 216594002790 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 216594002791 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 216594002792 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 216594002793 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 216594002794 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 216594002795 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 216594002796 G-loop; other site 216594002797 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 216594002798 DNA binding site [nucleotide binding] 216594002799 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 216594002800 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 216594002801 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594002802 endonuclease IV; Provisional; Region: PRK01060 216594002803 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 216594002804 AP (apurinic/apyrimidinic) site pocket; other site 216594002805 DNA interaction; other site 216594002806 Metal-binding active site; metal-binding site 216594002807 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 216594002808 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 216594002809 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594002810 active site 216594002811 enoyl-CoA hydratase; Provisional; Region: PRK12478 216594002812 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594002813 substrate binding site [chemical binding]; other site 216594002814 oxyanion hole (OAH) forming residues; other site 216594002815 trimer interface [polypeptide binding]; other site 216594002816 PaaX-like protein; Region: PaaX; pfam07848 216594002817 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 216594002818 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594002819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594002820 substrate binding site [chemical binding]; other site 216594002821 oxyanion hole (OAH) forming residues; other site 216594002822 trimer interface [polypeptide binding]; other site 216594002823 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594002824 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594002825 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 216594002826 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 216594002827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002829 WHG domain; Region: WHG; pfam13305 216594002830 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 216594002831 S17 interaction site [polypeptide binding]; other site 216594002832 S8 interaction site; other site 216594002833 16S rRNA interaction site [nucleotide binding]; other site 216594002834 streptomycin interaction site [chemical binding]; other site 216594002835 23S rRNA interaction site [nucleotide binding]; other site 216594002836 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 216594002837 30S ribosomal protein S7; Validated; Region: PRK05302 216594002838 elongation factor G; Reviewed; Region: PRK00007 216594002839 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 216594002840 G1 box; other site 216594002841 putative GEF interaction site [polypeptide binding]; other site 216594002842 GTP/Mg2+ binding site [chemical binding]; other site 216594002843 Switch I region; other site 216594002844 G2 box; other site 216594002845 G3 box; other site 216594002846 Switch II region; other site 216594002847 G4 box; other site 216594002848 G5 box; other site 216594002849 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 216594002850 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 216594002851 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 216594002852 elongation factor Tu; Reviewed; Region: PRK00049 216594002853 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 216594002854 G1 box; other site 216594002855 GEF interaction site [polypeptide binding]; other site 216594002856 GTP/Mg2+ binding site [chemical binding]; other site 216594002857 Switch I region; other site 216594002858 G2 box; other site 216594002859 G3 box; other site 216594002860 Switch II region; other site 216594002861 G4 box; other site 216594002862 G5 box; other site 216594002863 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 216594002864 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 216594002865 Antibiotic Binding Site [chemical binding]; other site 216594002866 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 216594002867 classical (c) SDRs; Region: SDR_c; cd05233 216594002868 NAD(P) binding site [chemical binding]; other site 216594002869 active site 216594002870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 216594002871 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594002872 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 216594002873 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 216594002874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594002875 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 216594002876 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 216594002877 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594002878 FeS/SAM binding site; other site 216594002879 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 216594002880 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 216594002881 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216594002882 phosphate binding site [ion binding]; other site 216594002883 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 216594002884 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 216594002885 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 216594002886 Probable Catalytic site; other site 216594002887 metal-binding site 216594002888 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 216594002889 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594002890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594002891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594002892 sequence-specific DNA binding site [nucleotide binding]; other site 216594002893 salt bridge; other site 216594002894 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594002895 PPE family; Region: PPE; pfam00823 216594002896 PE-PPE domain; Region: PE-PPE; pfam08237 216594002897 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594002898 PPE family; Region: PPE; pfam00823 216594002899 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594002900 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594002901 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594002902 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594002903 MURD23; Overlaps a PPE family gene 216594002904 Secretory lipase; Region: LIP; pfam03583 216594002905 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 216594002906 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 216594002907 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 216594002908 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 216594002909 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 216594002910 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 216594002911 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 216594002912 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 216594002913 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 216594002914 putative translocon binding site; other site 216594002915 protein-rRNA interface [nucleotide binding]; other site 216594002916 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 216594002917 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 216594002918 G-X-X-G motif; other site 216594002919 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 216594002920 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 216594002921 23S rRNA interface [nucleotide binding]; other site 216594002922 5S rRNA interface [nucleotide binding]; other site 216594002923 putative antibiotic binding site [chemical binding]; other site 216594002924 L25 interface [polypeptide binding]; other site 216594002925 L27 interface [polypeptide binding]; other site 216594002926 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 216594002927 L23 interface [polypeptide binding]; other site 216594002928 signal recognition particle (SRP54) interaction site; other site 216594002929 trigger factor interaction site; other site 216594002930 23S rRNA interface [nucleotide binding]; other site 216594002931 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 216594002932 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594002933 Sulfatase; Region: Sulfatase; pfam00884 216594002934 Laminin G domain; Region: LamG; smart00282 216594002935 Uncharacterized conserved protein [Function unknown]; Region: COG1262 216594002936 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 216594002937 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 216594002938 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 216594002939 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 216594002940 RNA binding site [nucleotide binding]; other site 216594002941 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 216594002942 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 216594002943 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 216594002944 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 216594002945 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 216594002946 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 216594002947 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216594002948 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216594002949 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 216594002950 5S rRNA interface [nucleotide binding]; other site 216594002951 23S rRNA interface [nucleotide binding]; other site 216594002952 L5 interface [polypeptide binding]; other site 216594002953 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 216594002954 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 216594002955 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 216594002956 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 216594002957 23S rRNA binding site [nucleotide binding]; other site 216594002958 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 216594002959 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 216594002960 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594002961 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 216594002962 tandem repeat interface [polypeptide binding]; other site 216594002963 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 216594002964 oligomer interface [polypeptide binding]; other site 216594002965 active site residues [active] 216594002966 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 216594002967 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 216594002968 tandem repeat interface [polypeptide binding]; other site 216594002969 oligomer interface [polypeptide binding]; other site 216594002970 active site residues [active] 216594002971 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594002972 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594002973 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594002974 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594002975 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594002976 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594002977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594002978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594002979 S-adenosylmethionine binding site [chemical binding]; other site 216594002980 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216594002981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216594002982 L-fuculose-phosphate aldolase; Validated; Region: PRK05874 216594002983 intersubunit interface [polypeptide binding]; other site 216594002984 active site 216594002985 Zn2+ binding site [ion binding]; other site 216594002986 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216594002987 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 216594002988 putative ligand binding site [chemical binding]; other site 216594002989 putative NAD binding site [chemical binding]; other site 216594002990 catalytic site [active] 216594002991 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216594002992 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216594002993 nucleotide binding site [chemical binding]; other site 216594002994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216594002995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594002996 Coenzyme A binding pocket [chemical binding]; other site 216594002997 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594002998 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594002999 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594003000 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594003001 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 216594003002 SecY translocase; Region: SecY; pfam00344 216594003003 adenylate kinase; Reviewed; Region: adk; PRK00279 216594003004 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 216594003005 AMP-binding site [chemical binding]; other site 216594003006 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 216594003007 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 216594003008 active site 216594003009 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 216594003010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594003011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594003012 DNA binding residues [nucleotide binding] 216594003013 Putative zinc-finger; Region: zf-HC2; pfam13490 216594003014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216594003015 MarR family; Region: MarR; pfam01047 216594003016 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594003017 TIGR03086 family protein; Region: TIGR03086 216594003018 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216594003019 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 216594003020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594003021 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 216594003022 substrate binding pocket [chemical binding]; other site 216594003023 FAD binding site [chemical binding]; other site 216594003024 catalytic base [active] 216594003025 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 216594003026 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 216594003027 tetrameric interface [polypeptide binding]; other site 216594003028 NAD binding site [chemical binding]; other site 216594003029 catalytic residues [active] 216594003030 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 216594003031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594003032 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 216594003033 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 216594003034 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 216594003035 NAD binding site [chemical binding]; other site 216594003036 substrate binding site [chemical binding]; other site 216594003037 homodimer interface [polypeptide binding]; other site 216594003038 active site 216594003039 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 216594003040 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594003041 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 216594003042 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 216594003043 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 216594003044 rRNA binding site [nucleotide binding]; other site 216594003045 predicted 30S ribosome binding site; other site 216594003046 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 216594003047 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 216594003048 30S ribosomal protein S13; Region: bact_S13; TIGR03631 216594003049 30S ribosomal protein S11; Validated; Region: PRK05309 216594003050 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 216594003051 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 216594003052 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216594003053 RNA binding surface [nucleotide binding]; other site 216594003054 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 216594003055 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 216594003056 alphaNTD homodimer interface [polypeptide binding]; other site 216594003057 alphaNTD - beta interaction site [polypeptide binding]; other site 216594003058 alphaNTD - beta' interaction site [polypeptide binding]; other site 216594003059 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 216594003060 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 216594003061 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 216594003062 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 216594003063 active site 216594003064 dimerization interface 3.5A [polypeptide binding]; other site 216594003065 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 216594003066 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003067 PPE family; Region: PPE; pfam00823 216594003068 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594003069 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003070 PPE family; Region: PPE; pfam00823 216594003071 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594003072 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 216594003073 Cutinase; Region: Cutinase; pfam01083 216594003074 Cutinase; Region: Cutinase; pfam01083 216594003075 ESX-4 216594003076 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 216594003077 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 216594003078 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 216594003079 active site 216594003080 catalytic residues [active] 216594003081 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 216594003082 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 216594003083 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594003084 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 216594003085 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594003086 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594003087 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 216594003088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 216594003089 Proteins of 100 residues with WXG; Region: WXG100; cl02005 216594003090 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 216594003091 23S rRNA interface [nucleotide binding]; other site 216594003092 L3 interface [polypeptide binding]; other site 216594003093 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 216594003094 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 216594003095 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 216594003096 active site 216594003097 substrate binding site [chemical binding]; other site 216594003098 metal binding site [ion binding]; metal-binding site 216594003099 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 216594003100 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594003101 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 216594003102 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 216594003103 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 216594003104 glutaminase active site [active] 216594003105 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216594003106 dimer interface [polypeptide binding]; other site 216594003107 active site 216594003108 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216594003109 dimer interface [polypeptide binding]; other site 216594003110 active site 216594003111 Uncharacterized conserved protein [Function unknown]; Region: COG0062 216594003112 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 216594003113 putative substrate binding site [chemical binding]; other site 216594003114 putative ATP binding site [chemical binding]; other site 216594003115 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 216594003116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594003117 catalytic residue [active] 216594003118 alanine racemase; Reviewed; Region: alr; PRK00053 216594003119 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 216594003120 active site 216594003121 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216594003122 dimer interface [polypeptide binding]; other site 216594003123 substrate binding site [chemical binding]; other site 216594003124 catalytic residues [active] 216594003125 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594003126 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 216594003127 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 216594003128 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 216594003129 Glycoprotease family; Region: Peptidase_M22; pfam00814 216594003130 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 216594003131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594003132 Coenzyme A binding pocket [chemical binding]; other site 216594003133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216594003134 UGMP family protein; Validated; Region: PRK09604 216594003135 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 216594003136 oligomerisation interface [polypeptide binding]; other site 216594003137 mobile loop; other site 216594003138 roof hairpin; other site 216594003139 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 216594003140 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216594003141 ring oligomerisation interface [polypeptide binding]; other site 216594003142 ATP/Mg binding site [chemical binding]; other site 216594003143 stacking interactions; other site 216594003144 hinge regions; other site 216594003145 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594003146 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003147 PPE family; Region: PPE; pfam00823 216594003148 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003149 PPE family; Region: PPE; pfam00823 216594003150 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 216594003151 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 216594003152 active site 216594003153 Transcription factor WhiB; Region: Whib; pfam02467 216594003154 MURD24; Contains a single CDS encoding a conserved hypothetical protein, function unknown 216594003155 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 216594003156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594003157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 216594003158 DNA binding residues [nucleotide binding] 216594003159 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 216594003160 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216594003161 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 216594003162 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 216594003163 active site 216594003164 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 216594003165 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216594003166 phosphate binding site [ion binding]; other site 216594003167 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003168 PPE family; Region: PPE; pfam00823 216594003169 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594003170 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216594003171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594003172 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594003173 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 216594003174 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 216594003175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594003176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003177 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 216594003178 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 216594003179 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 216594003180 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 216594003181 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 216594003182 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594003183 motif II; other site 216594003184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594003185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003186 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 216594003187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594003188 putative substrate translocation pore; other site 216594003189 Predicted transcriptional regulators [Transcription]; Region: COG1733 216594003190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594003191 dimerization interface [polypeptide binding]; other site 216594003192 putative DNA binding site [nucleotide binding]; other site 216594003193 putative Zn2+ binding site [ion binding]; other site 216594003194 GMP synthase; Reviewed; Region: guaA; PRK00074 216594003195 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 216594003196 AMP/PPi binding site [chemical binding]; other site 216594003197 candidate oxyanion hole; other site 216594003198 catalytic triad [active] 216594003199 potential glutamine specificity residues [chemical binding]; other site 216594003200 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 216594003201 ATP Binding subdomain [chemical binding]; other site 216594003202 Ligand Binding sites [chemical binding]; other site 216594003203 Dimerization subdomain; other site 216594003204 DNA Polymerase Y-family; Region: PolY_like; cd03468 216594003205 active site 216594003206 DNA binding site [nucleotide binding] 216594003207 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 216594003208 active site 216594003209 short chain dehydrogenase; Provisional; Region: PRK07201 216594003210 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 216594003211 putative NAD(P) binding site [chemical binding]; other site 216594003212 active site 216594003213 putative substrate binding site [chemical binding]; other site 216594003214 classical (c) SDRs; Region: SDR_c; cd05233 216594003215 NAD(P) binding site [chemical binding]; other site 216594003216 active site 216594003217 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594003218 catalytic core [active] 216594003219 enoyl-CoA hydratase; Region: PLN02864 216594003220 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594003221 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 216594003222 dimer interaction site [polypeptide binding]; other site 216594003223 substrate-binding tunnel; other site 216594003224 active site 216594003225 catalytic site [active] 216594003226 substrate binding site [chemical binding]; other site 216594003227 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 216594003228 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 216594003229 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594003230 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594003231 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 216594003232 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 216594003233 active site 216594003234 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 216594003235 generic binding surface II; other site 216594003236 generic binding surface I; other site 216594003237 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216594003238 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 216594003239 FMN binding site [chemical binding]; other site 216594003240 dimer interface [polypeptide binding]; other site 216594003241 PE family; Region: PE; pfam00934 216594003242 MURD25; Contains two CDS encoding PE-PGRS family proteins 216594003243 PE family; Region: PE; pfam00934 216594003244 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 216594003245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594003246 S-adenosylmethionine binding site [chemical binding]; other site 216594003247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216594003248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594003249 ATP binding site [chemical binding]; other site 216594003250 Mg2+ binding site [ion binding]; other site 216594003251 G-X-G motif; other site 216594003252 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 216594003253 Protein of unknown function (DUF742); Region: DUF742; pfam05331 216594003254 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 216594003255 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 216594003256 G1 box; other site 216594003257 GTP/Mg2+ binding site [chemical binding]; other site 216594003258 G2 box; other site 216594003259 Switch I region; other site 216594003260 G3 box; other site 216594003261 Switch II region; other site 216594003262 G4 box; other site 216594003263 G5 box; other site 216594003264 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 216594003265 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216594003266 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216594003267 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594003268 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594003269 acyl-activating enzyme (AAE) consensus motif; other site 216594003270 active site 216594003271 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 216594003272 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 216594003273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594003274 catalytic residue [active] 216594003275 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 216594003276 MURD26; Contains a bioF2 orthologue. The predicted product is involved in biotin synthesis at the first step 216594003277 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216594003278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594003279 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594003280 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594003281 phosphopeptide binding site; other site 216594003282 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594003283 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594003284 phosphopeptide binding site; other site 216594003285 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216594003286 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 216594003287 Walker A/P-loop; other site 216594003288 ATP binding site [chemical binding]; other site 216594003289 Q-loop/lid; other site 216594003290 ABC transporter signature motif; other site 216594003291 Walker B; other site 216594003292 D-loop; other site 216594003293 H-loop/switch region; other site 216594003294 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594003295 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594003296 phosphopeptide binding site; other site 216594003297 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594003298 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594003299 phosphopeptide binding site; other site 216594003300 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 216594003301 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 216594003302 Walker A/P-loop; other site 216594003303 ATP binding site [chemical binding]; other site 216594003304 Q-loop/lid; other site 216594003305 ABC transporter signature motif; other site 216594003306 Walker B; other site 216594003307 D-loop; other site 216594003308 H-loop/switch region; other site 216594003309 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216594003310 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216594003311 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 216594003312 active site 216594003313 FMN binding site [chemical binding]; other site 216594003314 substrate binding site [chemical binding]; other site 216594003315 putative catalytic residue [active] 216594003316 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 216594003317 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 216594003318 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 216594003319 homodimer interface [polypeptide binding]; other site 216594003320 NADP binding site [chemical binding]; other site 216594003321 substrate binding site [chemical binding]; other site 216594003322 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 216594003323 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594003324 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594003325 FAD binding domain; Region: FAD_binding_4; pfam01565 216594003326 Berberine and berberine like; Region: BBE; pfam08031 216594003327 acyl-CoA synthetase; Validated; Region: PRK05850 216594003328 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594003329 acyl-activating enzyme (AAE) consensus motif; other site 216594003330 active site 216594003331 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594003332 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594003333 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594003334 active site 216594003335 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594003336 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594003337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594003338 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594003339 Enoylreductase; Region: PKS_ER; smart00829 216594003340 NAD(P) binding site [chemical binding]; other site 216594003341 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594003342 putative NADP binding site [chemical binding]; other site 216594003343 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594003344 active site 216594003345 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594003346 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594003347 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594003348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594003349 S-adenosylmethionine binding site [chemical binding]; other site 216594003350 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 216594003351 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 216594003352 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 216594003353 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216594003354 homodimer interface [polypeptide binding]; other site 216594003355 substrate-cofactor binding pocket; other site 216594003356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594003357 catalytic residue [active] 216594003358 isocitrate dehydrogenase; Validated; Region: PRK08299 216594003359 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594003360 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 216594003361 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 216594003362 active site 216594003363 HIGH motif; other site 216594003364 dimer interface [polypeptide binding]; other site 216594003365 KMSKS motif; other site 216594003366 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 216594003367 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 216594003368 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 216594003369 active site 216594003370 dimer interface [polypeptide binding]; other site 216594003371 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 216594003372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594003373 putative substrate translocation pore; other site 216594003374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594003375 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216594003376 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 216594003377 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216594003378 DNA binding residues [nucleotide binding] 216594003379 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 216594003380 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 216594003381 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216594003382 metal ion-dependent adhesion site (MIDAS); other site 216594003383 PE family; Region: PE; pfam00934 216594003384 MURD27; Contains a CDS encoding a PE-PGRS family protein 216594003385 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 216594003386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594003387 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216594003388 DNA binding residues [nucleotide binding] 216594003389 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216594003390 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216594003391 PE family; Region: PE; pfam00934 216594003392 MURD28; Contains a CDS encoding a large PE-PGRS family protein 216594003393 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 216594003394 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 216594003395 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 216594003396 L-aspartate oxidase; Provisional; Region: PRK06175 216594003397 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216594003398 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 216594003399 putative Iron-sulfur protein interface [polypeptide binding]; other site 216594003400 putative proximal heme binding site [chemical binding]; other site 216594003401 putative SdhC-like subunit interface [polypeptide binding]; other site 216594003402 putative distal heme binding site [chemical binding]; other site 216594003403 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 216594003404 putative Iron-sulfur protein interface [polypeptide binding]; other site 216594003405 putative proximal heme binding site [chemical binding]; other site 216594003406 putative SdhD-like interface [polypeptide binding]; other site 216594003407 putative distal heme binding site [chemical binding]; other site 216594003408 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 216594003409 active site 216594003410 catalytic motif [active] 216594003411 Zn binding site [ion binding]; other site 216594003412 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 216594003413 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216594003414 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216594003415 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 216594003416 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 216594003417 adenosine deaminase; Provisional; Region: PRK09358 216594003418 active site 216594003419 PE family; Region: PE; pfam00934 216594003420 MURD29; Contains two CDS encoding PE-PGRS family proteins 216594003421 PE family; Region: PE; pfam00934 216594003422 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 216594003423 allantoicase; Provisional; Region: PRK13257 216594003424 Allantoicase repeat; Region: Allantoicase; pfam03561 216594003425 Allantoicase repeat; Region: Allantoicase; pfam03561 216594003426 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 216594003427 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 216594003428 active site 216594003429 catalytic site [active] 216594003430 tetramer interface [polypeptide binding]; other site 216594003431 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 216594003432 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 216594003433 Na binding site [ion binding]; other site 216594003434 putative substrate binding site [chemical binding]; other site 216594003435 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594003436 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594003437 active site 216594003438 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594003439 Phosphoesterase family; Region: Phosphoesterase; pfam04185 216594003440 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216594003441 active site 216594003442 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 216594003443 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 216594003444 active site 216594003445 substrate binding site [chemical binding]; other site 216594003446 metal binding site [ion binding]; metal-binding site 216594003447 purine nucleoside phosphorylase; Provisional; Region: PRK08202 216594003448 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 216594003449 amidohydrolase; Region: amidohydrolases; TIGR01891 216594003450 metal binding site [ion binding]; metal-binding site 216594003451 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 216594003452 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 216594003453 metal binding site [ion binding]; metal-binding site 216594003454 putative dimer interface [polypeptide binding]; other site 216594003455 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 216594003456 putative active site pocket [active] 216594003457 dimerization interface [polypeptide binding]; other site 216594003458 putative catalytic residue [active] 216594003459 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 216594003460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594003461 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216594003462 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 216594003463 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 216594003464 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 216594003465 active site 216594003466 FMN binding site [chemical binding]; other site 216594003467 substrate binding site [chemical binding]; other site 216594003468 3Fe-4S cluster binding site [ion binding]; other site 216594003469 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594003470 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 216594003471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594003472 motif II; other site 216594003473 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216594003474 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 216594003475 PhoU domain; Region: PhoU; pfam01895 216594003476 PhoU domain; Region: PhoU; pfam01895 216594003477 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 216594003478 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 216594003479 oligomer interface [polypeptide binding]; other site 216594003480 metal binding site [ion binding]; metal-binding site 216594003481 metal binding site [ion binding]; metal-binding site 216594003482 putative Cl binding site [ion binding]; other site 216594003483 aspartate ring; other site 216594003484 basic sphincter; other site 216594003485 hydrophobic gate; other site 216594003486 periplasmic entrance; other site 216594003487 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 216594003488 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216594003489 active site 216594003490 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594003491 Sulfatase; Region: Sulfatase; pfam00884 216594003492 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594003493 PBP superfamily domain; Region: PBP_like_2; cl17296 216594003494 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003495 PPE family; Region: PPE; pfam00823 216594003496 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 216594003497 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 216594003498 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 216594003499 putative DNA binding site [nucleotide binding]; other site 216594003500 catalytic residue [active] 216594003501 putative H2TH interface [polypeptide binding]; other site 216594003502 putative catalytic residues [active] 216594003503 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 216594003504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594003505 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 216594003506 ATP binding site [chemical binding]; other site 216594003507 putative Mg++ binding site [ion binding]; other site 216594003508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594003509 nucleotide binding region [chemical binding]; other site 216594003510 ATP-binding site [chemical binding]; other site 216594003511 DEAD/H associated; Region: DEAD_assoc; pfam08494 216594003512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594003513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003514 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 216594003515 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594003516 tetrameric interface [polypeptide binding]; other site 216594003517 NAD binding site [chemical binding]; other site 216594003518 catalytic residues [active] 216594003519 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 216594003520 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 216594003521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 216594003522 AsnC family; Region: AsnC_trans_reg; pfam01037 216594003523 L-lysine aminotransferase; Provisional; Region: PRK08297 216594003524 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594003525 inhibitor-cofactor binding pocket; inhibition site 216594003526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594003527 catalytic residue [active] 216594003528 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 216594003529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 216594003530 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 216594003531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594003532 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216594003533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 216594003534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594003535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003536 WHG domain; Region: WHG; pfam13305 216594003537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594003538 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594003539 active site 216594003540 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594003541 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594003542 acyl-activating enzyme (AAE) consensus motif; other site 216594003543 AMP binding site [chemical binding]; other site 216594003544 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594003545 Condensation domain; Region: Condensation; pfam00668 216594003546 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594003547 Condensation domain; Region: Condensation; pfam00668 216594003548 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594003549 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594003550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594003551 acyl-activating enzyme (AAE) consensus motif; other site 216594003552 AMP binding site [chemical binding]; other site 216594003553 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594003554 Condensation domain; Region: Condensation; pfam00668 216594003555 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594003556 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594003557 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 216594003558 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216594003559 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216594003560 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216594003561 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216594003562 carboxyltransferase (CT) interaction site; other site 216594003563 biotinylation site [posttranslational modification]; other site 216594003564 Fe-S metabolism associated domain; Region: SufE; cl00951 216594003565 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 216594003566 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 216594003567 active site residue [active] 216594003568 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 216594003569 active site residue [active] 216594003570 Maf-like protein; Region: Maf; pfam02545 216594003571 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 216594003572 active site 216594003573 dimer interface [polypeptide binding]; other site 216594003574 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 216594003575 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216594003576 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216594003577 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216594003578 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 216594003579 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 216594003580 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 216594003581 Bacterial PH domain; Region: DUF304; pfam03703 216594003582 Predicted membrane protein [Function unknown]; Region: COG2246 216594003583 GtrA-like protein; Region: GtrA; pfam04138 216594003584 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 216594003585 ATP-grasp domain; Region: ATP-grasp; pfam02222 216594003586 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 216594003587 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594003588 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 216594003589 FAD binding site [chemical binding]; other site 216594003590 homotetramer interface [polypeptide binding]; other site 216594003591 substrate binding pocket [chemical binding]; other site 216594003592 catalytic base [active] 216594003593 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216594003594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594003595 active site 216594003596 phosphorylation site [posttranslational modification] 216594003597 intermolecular recognition site; other site 216594003598 dimerization interface [polypeptide binding]; other site 216594003599 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 216594003600 CHASE3 domain; Region: CHASE3; pfam05227 216594003601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594003602 dimer interface [polypeptide binding]; other site 216594003603 phosphorylation site [posttranslational modification] 216594003604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594003605 ATP binding site [chemical binding]; other site 216594003606 Mg2+ binding site [ion binding]; other site 216594003607 G-X-G motif; other site 216594003608 Response regulator receiver domain; Region: Response_reg; pfam00072 216594003609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594003610 active site 216594003611 phosphorylation site [posttranslational modification] 216594003612 intermolecular recognition site; other site 216594003613 dimerization interface [polypeptide binding]; other site 216594003614 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216594003615 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216594003616 active site clefts [active] 216594003617 Carbonic anhydrase; Region: Pro_CA; smart00947 216594003618 zinc binding site [ion binding]; other site 216594003619 dimer interface [polypeptide binding]; other site 216594003620 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594003621 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594003622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594003623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003624 Predicted acyl esterases [General function prediction only]; Region: COG2936 216594003625 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 216594003626 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216594003627 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594003628 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594003629 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 216594003630 TIGR03089 family protein; Region: TIGR03089 216594003631 Transcriptional regulator [Transcription]; Region: LytR; COG1316 216594003632 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 216594003633 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 216594003634 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 216594003635 NADP binding site [chemical binding]; other site 216594003636 active site 216594003637 putative substrate binding site [chemical binding]; other site 216594003638 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216594003639 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 216594003640 Probable Catalytic site; other site 216594003641 metal-binding site 216594003642 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 216594003643 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 216594003644 active site 216594003645 Substrate binding site; other site 216594003646 Mg++ binding site; other site 216594003647 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216594003648 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 216594003649 nudix motif; other site 216594003650 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 216594003651 Methyltransferase domain; Region: Methyltransf_26; pfam13659 216594003652 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 216594003653 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 216594003654 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 216594003655 FMN binding site [chemical binding]; other site 216594003656 dimer interface [polypeptide binding]; other site 216594003657 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 216594003658 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 216594003659 dimer interface [polypeptide binding]; other site 216594003660 phosphate binding site [ion binding]; other site 216594003661 Transcription factor WhiB; Region: Whib; pfam02467 216594003662 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 216594003663 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 216594003664 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 216594003665 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 216594003666 active site 216594003667 substrate binding site [chemical binding]; other site 216594003668 metal binding site [ion binding]; metal-binding site 216594003669 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 216594003670 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 216594003671 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 216594003672 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 216594003673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594003674 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 216594003675 amino acid transporter; Region: 2A0306; TIGR00909 216594003676 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 216594003677 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 216594003678 Fatty acid desaturase; Region: FA_desaturase; pfam00487 216594003679 Di-iron ligands [ion binding]; other site 216594003680 Rubredoxin [Energy production and conversion]; Region: COG1773 216594003681 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 216594003682 iron binding site [ion binding]; other site 216594003683 Rubredoxin [Energy production and conversion]; Region: COG1773 216594003684 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 216594003685 iron binding site [ion binding]; other site 216594003686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003687 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 216594003688 Adenosylhomocysteinase; Provisional; Region: PTZ00075 216594003689 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 216594003690 homotetramer interface [polypeptide binding]; other site 216594003691 ligand binding site [chemical binding]; other site 216594003692 catalytic site [active] 216594003693 NAD binding site [chemical binding]; other site 216594003694 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003695 PPE family; Region: PPE; pfam00823 216594003696 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594003697 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594003698 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 216594003699 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 216594003700 TMP-binding site; other site 216594003701 ATP-binding site [chemical binding]; other site 216594003702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594003703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594003704 active site 216594003705 phosphorylation site [posttranslational modification] 216594003706 intermolecular recognition site; other site 216594003707 dimerization interface [polypeptide binding]; other site 216594003708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594003709 DNA binding site [nucleotide binding] 216594003710 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216594003711 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594003712 dimerization interface [polypeptide binding]; other site 216594003713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594003714 dimer interface [polypeptide binding]; other site 216594003715 phosphorylation site [posttranslational modification] 216594003716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594003717 ATP binding site [chemical binding]; other site 216594003718 Mg2+ binding site [ion binding]; other site 216594003719 G-X-G motif; other site 216594003720 lipoprotein LpqB; Provisional; Region: PRK13616 216594003721 Sporulation and spore germination; Region: Germane; pfam10646 216594003722 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 216594003723 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 216594003724 30S subunit binding site; other site 216594003725 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 216594003726 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 216594003727 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594003728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594003729 putative substrate translocation pore; other site 216594003730 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594003731 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594003732 ligand binding site [chemical binding]; other site 216594003733 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216594003734 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 216594003735 nucleophile elbow; other site 216594003736 Phospholipid methyltransferase; Region: PEMT; cl17370 216594003737 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 216594003738 TrkA-C domain; Region: TrkA_C; pfam02080 216594003739 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 216594003740 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 216594003741 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594003742 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594003743 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 216594003744 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 216594003745 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216594003746 FAD binding pocket [chemical binding]; other site 216594003747 FAD binding motif [chemical binding]; other site 216594003748 phosphate binding motif [ion binding]; other site 216594003749 beta-alpha-beta structure motif; other site 216594003750 NAD binding pocket [chemical binding]; other site 216594003751 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594003752 catalytic loop [active] 216594003753 iron binding site [ion binding]; other site 216594003754 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 216594003755 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 216594003756 putative di-iron ligands [ion binding]; other site 216594003757 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 216594003758 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 216594003759 putative di-iron ligands [ion binding]; other site 216594003760 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 216594003761 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594003762 dimer interface [polypeptide binding]; other site 216594003763 active site 216594003764 Predicted transcriptional regulators [Transcription]; Region: COG1733 216594003765 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216594003766 Predicted GTPases [General function prediction only]; Region: COG1162 216594003767 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 216594003768 GTPase/Zn-binding domain interface [polypeptide binding]; other site 216594003769 GTP/Mg2+ binding site [chemical binding]; other site 216594003770 G4 box; other site 216594003771 G5 box; other site 216594003772 G1 box; other site 216594003773 Switch I region; other site 216594003774 G2 box; other site 216594003775 G3 box; other site 216594003776 Switch II region; other site 216594003777 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 216594003778 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 216594003779 hinge; other site 216594003780 active site 216594003781 Uncharacterized conserved protein [Function unknown]; Region: COG2135 216594003782 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 216594003783 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216594003784 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216594003785 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594003786 MURD30; Overlaps the 5' end of a CDS encoding a conserved hypothetical membrane protein 216594003787 AAA ATPase domain; Region: AAA_16; pfam13191 216594003788 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594003789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594003790 DNA binding residues [nucleotide binding] 216594003791 dimerization interface [polypeptide binding]; other site 216594003792 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 216594003793 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 216594003794 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 216594003795 putative deacylase active site [active] 216594003796 short chain dehydrogenase; Provisional; Region: PRK08278 216594003797 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 216594003798 NAD(P) binding site [chemical binding]; other site 216594003799 homodimer interface [polypeptide binding]; other site 216594003800 active site 216594003801 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 216594003802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594003803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594003804 DNA binding residues [nucleotide binding] 216594003805 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 216594003806 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216594003807 carboxyltransferase (CT) interaction site; other site 216594003808 biotinylation site [posttranslational modification]; other site 216594003809 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 216594003810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216594003811 Histidine kinase; Region: HisKA_2; pfam07568 216594003812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594003813 ATP binding site [chemical binding]; other site 216594003814 Mg2+ binding site [ion binding]; other site 216594003815 G-X-G motif; other site 216594003816 Transcription factor WhiB; Region: Whib; pfam02467 216594003817 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 216594003818 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 216594003819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216594003820 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216594003821 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 216594003822 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216594003823 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594003824 catalytic core [active] 216594003825 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216594003826 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216594003827 P-loop; other site 216594003828 Magnesium ion binding site [ion binding]; other site 216594003829 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 216594003830 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216594003831 Magnesium ion binding site [ion binding]; other site 216594003832 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216594003833 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216594003834 ATP binding site [chemical binding]; other site 216594003835 Mg++ binding site [ion binding]; other site 216594003836 motif III; other site 216594003837 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594003838 nucleotide binding region [chemical binding]; other site 216594003839 ATP-binding site [chemical binding]; other site 216594003840 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 216594003841 dinuclear metal binding motif [ion binding]; other site 216594003842 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 216594003843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594003844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003845 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 216594003846 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 216594003847 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 216594003848 ATP binding site [chemical binding]; other site 216594003849 substrate interface [chemical binding]; other site 216594003850 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216594003851 active site residue [active] 216594003852 TIGR02569 family protein; Region: TIGR02569_actnb 216594003853 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216594003854 active site 216594003855 DNA binding site [nucleotide binding] 216594003856 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594003857 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594003858 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216594003859 catalytic site [active] 216594003860 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 216594003861 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 216594003862 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 216594003863 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 216594003864 Part of AAA domain; Region: AAA_19; pfam13245 216594003865 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 216594003866 Ion channel; Region: Ion_trans_2; pfam07885 216594003867 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 216594003868 TrkA-N domain; Region: TrkA_N; pfam02254 216594003869 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 216594003870 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 216594003871 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 216594003872 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 216594003873 putative NADH binding site [chemical binding]; other site 216594003874 putative active site [active] 216594003875 nudix motif; other site 216594003876 putative metal binding site [ion binding]; other site 216594003877 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594003878 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 216594003879 catalytic residues [active] 216594003880 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 216594003881 Part of AAA domain; Region: AAA_19; pfam13245 216594003882 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 216594003883 Family description; Region: UvrD_C_2; pfam13538 216594003884 HRDC domain; Region: HRDC; pfam00570 216594003885 Transcription factor WhiB; Region: Whib; pfam02467 216594003886 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 216594003887 ABC1 family; Region: ABC1; pfam03109 216594003888 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216594003889 active site 216594003890 ATP binding site [chemical binding]; other site 216594003891 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 216594003892 Uncharacterized conserved protein [Function unknown]; Region: COG5282 216594003893 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 216594003894 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 216594003895 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216594003896 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216594003897 hypothetical protein; Validated; Region: PRK00068 216594003898 Uncharacterized conserved protein [Function unknown]; Region: COG1615 216594003899 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 216594003900 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594003901 MURD31; Putative insertion sequence 216594003902 Winged helix-turn helix; Region: HTH_29; pfam13551 216594003903 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216594003904 DNA-binding interface [nucleotide binding]; DNA binding site 216594003905 Homeodomain-like domain; Region: HTH_32; pfam13565 216594003906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216594003907 Integrase core domain; Region: rve; pfam00665 216594003908 Integrase core domain; Region: rve_3; pfam13683 216594003909 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216594003910 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594003911 Sulfatase; Region: Sulfatase; pfam00884 216594003912 Sulfatase; Region: Sulfatase; cl17466 216594003913 SnoaL-like domain; Region: SnoaL_4; pfam13577 216594003914 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594003915 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594003916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216594003917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594003918 non-specific DNA binding site [nucleotide binding]; other site 216594003919 salt bridge; other site 216594003920 sequence-specific DNA binding site [nucleotide binding]; other site 216594003921 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 216594003922 Domain of unknown function (DUF955); Region: DUF955; pfam06114 216594003923 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 216594003924 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 216594003925 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 216594003926 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216594003927 tetramer interface [polypeptide binding]; other site 216594003928 active site 216594003929 Mg2+/Mn2+ binding site [ion binding]; other site 216594003930 citrate synthase; Provisional; Region: PRK14033 216594003931 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 216594003932 oxalacetate binding site [chemical binding]; other site 216594003933 citrylCoA binding site [chemical binding]; other site 216594003934 coenzyme A binding site [chemical binding]; other site 216594003935 catalytic triad [active] 216594003936 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 216594003937 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 216594003938 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594003939 probable polyamine oxidase; Region: PLN02268 216594003940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594003941 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594003942 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594003943 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 216594003944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594003945 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216594003946 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 216594003947 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594003948 PE family; Region: PE; pfam00934 216594003949 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 216594003950 putative active site [active] 216594003951 putative substrate binding site [chemical binding]; other site 216594003952 ATP binding site [chemical binding]; other site 216594003953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594003954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003955 classical (c) SDRs; Region: SDR_c; cd05233 216594003956 NAD(P) binding site [chemical binding]; other site 216594003957 active site 216594003958 MURD32; Putative insertion sequence 216594003959 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 216594003960 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 216594003961 MoxR-like ATPases [General function prediction only]; Region: COG0714 216594003962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594003963 Walker A motif; other site 216594003964 ATP binding site [chemical binding]; other site 216594003965 Walker B motif; other site 216594003966 arginine finger; other site 216594003967 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 216594003968 Protein of unknown function DUF58; Region: DUF58; pfam01882 216594003969 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003970 PPE family; Region: PPE; pfam00823 216594003971 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594003972 MURD33; Functions of genes within this MURD unknown. Contains several CDS encoding PE/PPE family proteins, membrane proteins (inc. two putative zinc transporters), integrases, insertion sequences and regulatory genes. Situated immediately upstream of the Nuo locus (NADH- ubiquinone oxidoreductase chain) 216594003973 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 216594003974 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 216594003975 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 216594003976 Transposase; Region: HTH_Tnp_1; cl17663 216594003977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216594003978 putative transposase OrfB; Reviewed; Region: PHA02517 216594003979 HTH-like domain; Region: HTH_21; pfam13276 216594003980 Integrase core domain; Region: rve; pfam00665 216594003981 Integrase core domain; Region: rve_3; pfam13683 216594003982 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594003983 Double zinc ribbon; Region: DZR; pfam12773 216594003984 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 216594003985 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 216594003986 putative homodimer interface [polypeptide binding]; other site 216594003987 putative homotetramer interface [polypeptide binding]; other site 216594003988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594003989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594003990 cyclase homology domain; Region: CHD; cd07302 216594003991 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594003992 nucleotidyl binding site; other site 216594003993 metal binding site [ion binding]; metal-binding site 216594003994 dimer interface [polypeptide binding]; other site 216594003995 YHS domain; Region: YHS; pfam04945 216594003996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594003997 S-adenosylmethionine binding site [chemical binding]; other site 216594003998 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594003999 PPE family; Region: PPE; pfam00823 216594004000 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 216594004001 active site clefts [active] 216594004002 zinc binding site [ion binding]; other site 216594004003 dimer interface [polypeptide binding]; other site 216594004004 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 216594004005 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594004006 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594004007 active site 216594004008 ATP binding site [chemical binding]; other site 216594004009 substrate binding site [chemical binding]; other site 216594004010 activation loop (A-loop); other site 216594004011 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 216594004012 Predicted membrane protein [Function unknown]; Region: COG3462 216594004013 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216594004014 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 216594004015 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 216594004016 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594004017 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594004018 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594004019 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 216594004020 active site 216594004021 DNA binding site [nucleotide binding] 216594004022 Int/Topo IB signature motif; other site 216594004023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594004024 active site 216594004025 DNA binding site [nucleotide binding] 216594004026 Int/Topo IB signature motif; other site 216594004027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 216594004028 Transposase; Region: DDE_Tnp_ISL3; pfam01610 216594004029 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 216594004030 PE family; Region: PE; pfam00934 216594004031 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 216594004032 ABC1 family; Region: ABC1; pfam03109 216594004033 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216594004034 active site 216594004035 ATP binding site [chemical binding]; other site 216594004036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004037 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 216594004038 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 216594004039 putative homotetramer interface [polypeptide binding]; other site 216594004040 putative homodimer interface [polypeptide binding]; other site 216594004041 putative allosteric switch controlling residues; other site 216594004042 putative metal binding site [ion binding]; other site 216594004043 putative homodimer-homodimer interface [polypeptide binding]; other site 216594004044 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 216594004045 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 216594004046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594004047 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594004048 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004049 PPE family; Region: PPE; pfam00823 216594004050 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594004051 putative transposase OrfB; Reviewed; Region: PHA02517 216594004052 HTH-like domain; Region: HTH_21; pfam13276 216594004053 Integrase core domain; Region: rve; pfam00665 216594004054 Integrase core domain; Region: rve_3; pfam13683 216594004055 Transposase; Region: HTH_Tnp_1; pfam01527 216594004056 putative transposase OrfB; Reviewed; Region: PHA02517 216594004057 HTH-like domain; Region: HTH_21; pfam13276 216594004058 Integrase core domain; Region: rve; pfam00665 216594004059 Integrase core domain; Region: rve_3; pfam13683 216594004060 Transposase; Region: HTH_Tnp_1; cl17663 216594004061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216594004062 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004063 PPE family; Region: PPE; pfam00823 216594004064 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594004065 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004066 PPE family; Region: PPE; pfam00823 216594004067 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594004068 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216594004069 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216594004070 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216594004071 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 216594004072 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004073 PPE family; Region: PPE; pfam00823 216594004074 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594004075 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 216594004076 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216594004077 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 216594004078 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216594004079 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 216594004080 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 216594004081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216594004082 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 216594004083 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 216594004084 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 216594004085 4Fe-4S binding domain; Region: Fer4; pfam00037 216594004086 4Fe-4S binding domain; Region: Fer4; pfam00037 216594004087 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 216594004088 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 216594004089 NADH dehydrogenase subunit G; Validated; Region: PRK07860 216594004090 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594004091 catalytic loop [active] 216594004092 iron binding site [ion binding]; other site 216594004093 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 216594004094 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216594004095 molybdopterin cofactor binding site; other site 216594004096 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 216594004097 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 216594004098 SLBB domain; Region: SLBB; pfam10531 216594004099 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 216594004100 NADH dehydrogenase subunit E; Validated; Region: PRK07539 216594004101 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 216594004102 putative dimer interface [polypeptide binding]; other site 216594004103 [2Fe-2S] cluster binding site [ion binding]; other site 216594004104 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 216594004105 NADH dehydrogenase subunit D; Validated; Region: PRK06075 216594004106 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 216594004107 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 216594004108 NADH dehydrogenase subunit B; Validated; Region: PRK06411 216594004109 NADH dehydrogenase subunit A; Validated; Region: PRK07928 216594004110 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004111 PPE family; Region: PPE; pfam00823 216594004112 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216594004113 Phosphoesterase family; Region: Phosphoesterase; pfam04185 216594004114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 216594004115 active site 216594004116 phosphorylation site [posttranslational modification] 216594004117 intermolecular recognition site; other site 216594004118 YceI-like domain; Region: YceI; pfam04264 216594004119 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594004120 Phosphotransferase enzyme family; Region: APH; pfam01636 216594004121 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 216594004122 putative active site [active] 216594004123 putative substrate binding site [chemical binding]; other site 216594004124 ATP binding site [chemical binding]; other site 216594004125 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594004126 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594004127 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594004128 active site 216594004129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004131 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 216594004132 active site 216594004133 catalytic residues [active] 216594004134 metal binding site [ion binding]; metal-binding site 216594004135 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594004136 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594004137 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 216594004138 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594004139 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216594004140 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 216594004141 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004142 PPE family; Region: PPE; pfam00823 216594004143 PE-PPE domain; Region: PE-PPE; pfam08237 216594004144 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216594004145 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 216594004146 NAD(P) binding site [chemical binding]; other site 216594004147 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 216594004148 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 216594004149 NADP binding site [chemical binding]; other site 216594004150 dimer interface [polypeptide binding]; other site 216594004151 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594004152 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 216594004153 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 216594004154 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 216594004155 active site 216594004156 Fe binding site [ion binding]; other site 216594004157 MURD34; function Unknown function, overlaps three CDS, two encoding hypothetical proteins and the other a putative oxidoreductase 216594004158 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 216594004159 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 216594004160 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594004161 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594004162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004164 acetaldehyde dehydrogenase; Validated; Region: PRK08300 216594004165 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 216594004166 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 216594004167 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 216594004168 active site 216594004169 catalytic residues [active] 216594004170 metal binding site [ion binding]; metal-binding site 216594004171 DmpG-like communication domain; Region: DmpG_comm; pfam07836 216594004172 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 216594004173 acetolactate synthase; Reviewed; Region: PRK08617 216594004174 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216594004175 PYR/PP interface [polypeptide binding]; other site 216594004176 dimer interface [polypeptide binding]; other site 216594004177 TPP binding site [chemical binding]; other site 216594004178 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216594004179 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 216594004180 TPP-binding site [chemical binding]; other site 216594004181 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594004182 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594004183 active site 216594004184 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594004185 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594004186 active site 216594004187 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 216594004188 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216594004189 active site 216594004190 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004191 PPE family; Region: PPE; pfam00823 216594004192 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594004193 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004194 PPE family; Region: PPE; pfam00823 216594004195 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594004196 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594004197 Ligand Binding Site [chemical binding]; other site 216594004198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594004199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594004200 active site 216594004201 phosphorylation site [posttranslational modification] 216594004202 intermolecular recognition site; other site 216594004203 dimerization interface [polypeptide binding]; other site 216594004204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594004205 DNA binding residues [nucleotide binding] 216594004206 dimerization interface [polypeptide binding]; other site 216594004207 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216594004208 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216594004209 GAF domain; Region: GAF_3; pfam13492 216594004210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216594004211 Histidine kinase; Region: HisKA_3; pfam07730 216594004212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594004213 ATP binding site [chemical binding]; other site 216594004214 Mg2+ binding site [ion binding]; other site 216594004215 G-X-G motif; other site 216594004216 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216594004217 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594004218 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594004219 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 216594004220 heme-binding site [chemical binding]; other site 216594004221 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 216594004222 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216594004223 dimer interface [polypeptide binding]; other site 216594004224 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594004225 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594004226 active site 216594004227 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594004228 FAD binding domain; Region: FAD_binding_4; pfam01565 216594004229 ferredoxin-NADP+ reductase; Region: PLN02852 216594004230 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594004231 peptide chain release factor 2; Validated; Region: prfB; PRK00578 216594004232 This domain is found in peptide chain release factors; Region: PCRF; smart00937 216594004233 RF-1 domain; Region: RF-1; pfam00472 216594004234 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216594004235 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216594004236 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 216594004237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594004238 Walker A/P-loop; other site 216594004239 ATP binding site [chemical binding]; other site 216594004240 Q-loop/lid; other site 216594004241 ABC transporter signature motif; other site 216594004242 Walker B; other site 216594004243 D-loop; other site 216594004244 H-loop/switch region; other site 216594004245 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 216594004246 FtsX-like permease family; Region: FtsX; pfam02687 216594004247 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 216594004248 SmpB-tmRNA interface; other site 216594004249 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 216594004250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594004251 ATP binding site [chemical binding]; other site 216594004252 Walker B motif; other site 216594004253 arginine finger; other site 216594004254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216594004255 TPR motif; other site 216594004256 binding surface 216594004257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216594004258 TPR motif; other site 216594004259 TPR repeat; Region: TPR_11; pfam13414 216594004260 binding surface 216594004261 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594004262 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 216594004263 PE family; Region: PE; pfam00934 216594004264 MspA; Region: MspA; pfam09203 216594004265 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 216594004266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594004267 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216594004268 active site 216594004269 Predicted transcriptional regulators [Transcription]; Region: COG1695 216594004270 Transcriptional regulator PadR-like family; Region: PadR; cl17335 216594004271 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 216594004272 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594004273 MURD35; Overlaps the 5' end of PE-PGRS family protein 216594004274 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004275 PPE family; Region: PPE; pfam00823 216594004276 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 216594004277 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594004278 glutaminase; Reviewed; Region: PRK12356 216594004279 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 216594004280 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 216594004281 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004282 PPE family; Region: PPE; pfam00823 216594004283 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 216594004284 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 216594004285 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 216594004286 Predicted transcriptional regulators [Transcription]; Region: COG1733 216594004287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594004288 dimerization interface [polypeptide binding]; other site 216594004289 putative DNA binding site [nucleotide binding]; other site 216594004290 putative Zn2+ binding site [ion binding]; other site 216594004291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594004292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594004293 active site 216594004294 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 216594004295 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594004296 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 216594004297 Prostaglandin dehydrogenases; Region: PGDH; cd05288 216594004298 NAD(P) binding site [chemical binding]; other site 216594004299 substrate binding site [chemical binding]; other site 216594004300 dimer interface [polypeptide binding]; other site 216594004301 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 216594004302 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 216594004303 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 216594004304 homodimer interface [polypeptide binding]; other site 216594004305 metal binding site [ion binding]; metal-binding site 216594004306 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 216594004307 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 216594004308 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 216594004309 MURD36; Function unknown; overlaps 5 CDS encoding a p450 hydroxlase and proteins with putative roles in tRNA biogenesis and methylation 216594004310 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 216594004311 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594004312 Cytochrome P450; Region: p450; cl12078 216594004313 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594004314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594004315 S-adenosylmethionine binding site [chemical binding]; other site 216594004316 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 216594004317 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216594004318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594004319 FeS/SAM binding site; other site 216594004320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 216594004321 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594004322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594004323 NAD(P) binding site [chemical binding]; other site 216594004324 active site 216594004325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004327 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594004328 SPFH domain / Band 7 family; Region: Band_7; pfam01145 216594004329 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 216594004330 hypothetical protein; Validated; Region: PRK00029 216594004331 Uncharacterized conserved protein [Function unknown]; Region: COG0397 216594004332 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 216594004333 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594004334 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594004335 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 216594004336 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594004337 Sulfatase; Region: Sulfatase; pfam00884 216594004338 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 216594004339 putative hydrophobic ligand binding site [chemical binding]; other site 216594004340 protein interface [polypeptide binding]; other site 216594004341 gate; other site 216594004342 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 216594004343 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 216594004344 active site 216594004345 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216594004346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594004347 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 216594004348 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594004349 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 216594004350 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594004351 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594004352 active site 216594004353 Protein of unknown function, DUF488; Region: DUF488; cl01246 216594004354 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594004355 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594004356 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 216594004357 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 216594004358 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 216594004359 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 216594004360 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 216594004361 camphor resistance protein CrcB; Provisional; Region: PRK14228 216594004362 camphor resistance protein CrcB; Provisional; Region: PRK14216 216594004363 phosphoglucomutase; Validated; Region: PRK07564 216594004364 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 216594004365 active site 216594004366 substrate binding site [chemical binding]; other site 216594004367 metal binding site [ion binding]; metal-binding site 216594004368 MURD37; Contains two CDS encoding large PE-PGRS family proteins. Also harbours hypothetical CDS encoding methyltransferase, regulatory and secreted protein 216594004369 PE family; Region: PE; pfam00934 216594004370 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594004371 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594004372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594004373 S-adenosylmethionine binding site [chemical binding]; other site 216594004374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004376 Transposase; Region: HTH_Tnp_1; cl17663 216594004377 HTH-like domain; Region: HTH_21; pfam13276 216594004378 Integrase core domain; Region: rve; pfam00665 216594004379 Integrase core domain; Region: rve_3; pfam13683 216594004380 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594004381 PE family; Region: PE; pfam00934 216594004382 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216594004383 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594004384 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594004385 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594004386 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594004387 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 216594004388 putative acyl-acceptor binding pocket; other site 216594004389 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594004390 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594004391 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 216594004392 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 216594004393 acyl-activating enzyme (AAE) consensus motif; other site 216594004394 putative AMP binding site [chemical binding]; other site 216594004395 putative active site [active] 216594004396 putative CoA binding site [chemical binding]; other site 216594004397 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594004398 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 216594004399 NAD(P) binding site [chemical binding]; other site 216594004400 catalytic residues [active] 216594004401 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 216594004402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594004403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 216594004404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004405 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 216594004406 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 216594004407 short chain dehydrogenase; Provisional; Region: PRK06180 216594004408 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216594004409 NADP binding site [chemical binding]; other site 216594004410 active site 216594004411 steroid binding site; other site 216594004412 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 216594004413 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 216594004414 nucleotide binding site [chemical binding]; other site 216594004415 putative NEF/HSP70 interaction site [polypeptide binding]; other site 216594004416 SBD interface [polypeptide binding]; other site 216594004417 carbon starvation protein A; Provisional; Region: PRK15015 216594004418 Carbon starvation protein CstA; Region: CstA; pfam02554 216594004419 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 216594004420 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 216594004421 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 216594004422 Multicopper oxidase; Region: Cu-oxidase; pfam00394 216594004423 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 216594004424 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594004425 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594004426 ligand binding site [chemical binding]; other site 216594004427 flexible hinge region; other site 216594004428 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 216594004429 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 216594004430 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 216594004431 active site 216594004432 DNA binding site [nucleotide binding] 216594004433 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 216594004434 DNA binding site [nucleotide binding] 216594004435 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594004436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594004437 NAD(P) binding site [chemical binding]; other site 216594004438 active site 216594004439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594004440 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594004441 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594004442 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 216594004443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594004444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594004445 active site 216594004446 Predicted transcriptional regulators [Transcription]; Region: COG1733 216594004447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594004448 dimerization interface [polypeptide binding]; other site 216594004449 putative DNA binding site [nucleotide binding]; other site 216594004450 putative Zn2+ binding site [ion binding]; other site 216594004451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594004452 S-adenosylmethionine binding site [chemical binding]; other site 216594004453 DUF35 OB-fold domain; Region: DUF35; pfam01796 216594004454 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594004455 active site 216594004456 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216594004457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594004458 DNA-binding site [nucleotide binding]; DNA binding site 216594004459 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216594004460 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216594004461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 216594004462 DNA-binding site [nucleotide binding]; DNA binding site 216594004463 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216594004464 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 216594004465 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 216594004466 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 216594004467 2-isopropylmalate synthase; Validated; Region: PRK03739 216594004468 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594004469 Cytochrome P450; Region: p450; cl12078 216594004470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004472 short chain dehydrogenase; Provisional; Region: PRK07832 216594004473 classical (c) SDRs; Region: SDR_c; cd05233 216594004474 NAD(P) binding site [chemical binding]; other site 216594004475 active site 216594004476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004478 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216594004479 Predicted flavoprotein [General function prediction only]; Region: COG0431 216594004480 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004481 PPE family; Region: PPE; pfam00823 216594004482 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004483 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594004484 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004485 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594004486 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004487 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594004488 MURD38; Contains a CDS encoding a single, large PPE family protein 216594004489 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 216594004490 catalytic residues [active] 216594004491 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 216594004492 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 216594004493 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 216594004494 Class I ribonucleotide reductase; Region: RNR_I; cd01679 216594004495 active site 216594004496 dimer interface [polypeptide binding]; other site 216594004497 catalytic residues [active] 216594004498 effector binding site; other site 216594004499 R2 peptide binding site; other site 216594004500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004502 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594004503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594004504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004506 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 216594004507 putative hydrophobic ligand binding site [chemical binding]; other site 216594004508 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 216594004509 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 216594004510 dimer interface [polypeptide binding]; other site 216594004511 putative radical transfer pathway; other site 216594004512 diiron center [ion binding]; other site 216594004513 tyrosyl radical; other site 216594004514 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 216594004515 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216594004516 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 216594004517 putative NAD(P) binding site [chemical binding]; other site 216594004518 putative substrate binding site [chemical binding]; other site 216594004519 catalytic Zn binding site [ion binding]; other site 216594004520 structural Zn binding site [ion binding]; other site 216594004521 dimer interface [polypeptide binding]; other site 216594004522 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 216594004523 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 216594004524 siderophore binding site; other site 216594004525 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 216594004526 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 216594004527 D-pathway; other site 216594004528 Putative ubiquinol binding site [chemical binding]; other site 216594004529 Low-spin heme (heme b) binding site [chemical binding]; other site 216594004530 Putative water exit pathway; other site 216594004531 Binuclear center (heme o3/CuB) [ion binding]; other site 216594004532 K-pathway; other site 216594004533 Putative proton exit pathway; other site 216594004534 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 216594004535 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 216594004536 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216594004537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594004538 motif II; other site 216594004539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594004540 dimerization interface [polypeptide binding]; other site 216594004541 putative DNA binding site [nucleotide binding]; other site 216594004542 putative Zn2+ binding site [ion binding]; other site 216594004543 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 216594004544 hydrogenase 4 subunit B; Validated; Region: PRK06521 216594004545 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216594004546 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 216594004547 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 216594004548 hydrogenase 4 subunit F; Validated; Region: PRK06458 216594004549 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216594004550 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 216594004551 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 216594004552 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 216594004553 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 216594004554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594004555 Walker A/P-loop; other site 216594004556 ATP binding site [chemical binding]; other site 216594004557 Q-loop/lid; other site 216594004558 ABC transporter signature motif; other site 216594004559 Walker B; other site 216594004560 D-loop; other site 216594004561 H-loop/switch region; other site 216594004562 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 216594004563 nudix motif; other site 216594004564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594004565 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 216594004566 substrate binding site [chemical binding]; other site 216594004567 oxyanion hole (OAH) forming residues; other site 216594004568 trimer interface [polypeptide binding]; other site 216594004569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594004570 S-adenosylmethionine binding site [chemical binding]; other site 216594004571 Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263 216594004572 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 216594004573 FOG: WD40-like repeat [Function unknown]; Region: COG1520 216594004574 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 216594004575 Trp docking motif [polypeptide binding]; other site 216594004576 active site 216594004577 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 216594004578 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 216594004579 trimer interface [polypeptide binding]; other site 216594004580 active site 216594004581 substrate binding site [chemical binding]; other site 216594004582 CoA binding site [chemical binding]; other site 216594004583 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594004584 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 216594004585 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 216594004586 DNA photolyase; Region: DNA_photolyase; pfam00875 216594004587 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 216594004588 TspO/MBR family; Region: TspO_MBR; pfam03073 216594004589 MMPL family; Region: MMPL; pfam03176 216594004590 MMPL family; Region: MMPL; pfam03176 216594004591 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 216594004592 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594004593 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216594004594 MarR family; Region: MarR; pfam01047 216594004595 SOUL heme-binding protein; Region: SOUL; pfam04832 216594004596 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 216594004597 putative hydrophobic ligand binding site [chemical binding]; other site 216594004598 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 216594004599 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 216594004600 putative NAD(P) binding site [chemical binding]; other site 216594004601 putative active site [active] 216594004602 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216594004603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594004604 NAD(P) binding site [chemical binding]; other site 216594004605 active site 216594004606 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594004607 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216594004608 Uncharacterized conserved protein [Function unknown]; Region: COG1543 216594004609 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 216594004610 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 216594004611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594004612 S-adenosylmethionine binding site [chemical binding]; other site 216594004613 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216594004614 Ligand binding site [chemical binding]; other site 216594004615 Electron transfer flavoprotein domain; Region: ETF; pfam01012 216594004616 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 216594004617 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 216594004618 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216594004619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 216594004620 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594004621 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216594004622 putative acyl-acceptor binding pocket; other site 216594004623 Domain of unknown function (DUF427); Region: DUF427; pfam04248 216594004624 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 216594004625 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 216594004626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594004627 catalytic residue [active] 216594004628 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 216594004629 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 216594004630 Ligand Binding Site [chemical binding]; other site 216594004631 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594004632 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 216594004633 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 216594004634 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 216594004635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594004636 FeS/SAM binding site; other site 216594004637 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 216594004638 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 216594004639 nucleotide binding pocket [chemical binding]; other site 216594004640 K-X-D-G motif; other site 216594004641 catalytic site [active] 216594004642 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 216594004643 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 216594004644 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 216594004645 Dimer interface [polypeptide binding]; other site 216594004646 BRCT sequence motif; other site 216594004647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594004648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594004649 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594004650 Transposase; Region: HTH_Tnp_1; pfam01527 216594004651 putative transposase OrfB; Reviewed; Region: PHA02517 216594004652 HTH-like domain; Region: HTH_21; pfam13276 216594004653 Integrase core domain; Region: rve; pfam00665 216594004654 Integrase core domain; Region: rve_3; pfam13683 216594004655 MURD39; Putative insertion sequence 216594004656 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 216594004657 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 216594004658 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 216594004659 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 216594004660 6-phosphofructokinase; Provisional; Region: PRK03202 216594004661 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 216594004662 active site 216594004663 ADP/pyrophosphate binding site [chemical binding]; other site 216594004664 dimerization interface [polypeptide binding]; other site 216594004665 allosteric effector site; other site 216594004666 fructose-1,6-bisphosphate binding site; other site 216594004667 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 216594004668 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 216594004669 GatB domain; Region: GatB_Yqey; smart00845 216594004670 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 216594004671 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 216594004672 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 216594004673 Predicted membrane protein [Function unknown]; Region: COG2259 216594004674 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 216594004675 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 216594004676 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216594004677 PYR/PP interface [polypeptide binding]; other site 216594004678 dimer interface [polypeptide binding]; other site 216594004679 TPP binding site [chemical binding]; other site 216594004680 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216594004681 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 216594004682 TPP-binding site [chemical binding]; other site 216594004683 dimer interface [polypeptide binding]; other site 216594004684 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 216594004685 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 216594004686 putative valine binding site [chemical binding]; other site 216594004687 dimer interface [polypeptide binding]; other site 216594004688 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 216594004689 ketol-acid reductoisomerase; Provisional; Region: PRK05479 216594004690 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 216594004691 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 216594004692 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 216594004693 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216594004694 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216594004695 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594004696 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 216594004697 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 216594004698 ligand binding site [chemical binding]; other site 216594004699 NAD binding site [chemical binding]; other site 216594004700 dimerization interface [polypeptide binding]; other site 216594004701 catalytic site [active] 216594004702 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 216594004703 putative L-serine binding site [chemical binding]; other site 216594004704 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 216594004705 tartrate dehydrogenase; Region: TTC; TIGR02089 216594004706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594004707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216594004708 putative substrate translocation pore; other site 216594004709 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 216594004710 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216594004711 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216594004712 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 216594004713 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216594004714 HIGH motif; other site 216594004715 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216594004716 active site 216594004717 KMSKS motif; other site 216594004718 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 216594004719 Nitronate monooxygenase; Region: NMO; pfam03060 216594004720 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216594004721 FMN binding site [chemical binding]; other site 216594004722 substrate binding site [chemical binding]; other site 216594004723 putative catalytic residue [active] 216594004724 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594004725 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594004726 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216594004727 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594004728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594004729 catalytic residue [active] 216594004730 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 216594004731 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216594004732 Bacterial transcriptional regulator; Region: IclR; pfam01614 216594004733 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 216594004734 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 216594004735 substrate binding site [chemical binding]; other site 216594004736 ligand binding site [chemical binding]; other site 216594004737 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 216594004738 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 216594004739 substrate binding site [chemical binding]; other site 216594004740 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216594004741 IHF - DNA interface [nucleotide binding]; other site 216594004742 IHF dimer interface [polypeptide binding]; other site 216594004743 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 216594004744 active site 216594004745 Ap6A binding site [chemical binding]; other site 216594004746 nudix motif; other site 216594004747 metal binding site [ion binding]; metal-binding site 216594004748 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594004749 catalytic core [active] 216594004750 polyphosphate kinase; Provisional; Region: PRK05443 216594004751 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 216594004752 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 216594004753 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 216594004754 putative domain interface [polypeptide binding]; other site 216594004755 putative active site [active] 216594004756 catalytic site [active] 216594004757 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 216594004758 putative active site [active] 216594004759 catalytic site [active] 216594004760 Guanylyl transferase CofC like; Region: CofC; cl17472 216594004761 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 216594004762 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 216594004763 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 216594004764 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 216594004765 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 216594004766 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 216594004767 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 216594004768 thiamine monophosphate kinase; Provisional; Region: PRK05731 216594004769 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 216594004770 ATP binding site [chemical binding]; other site 216594004771 dimerization interface [polypeptide binding]; other site 216594004772 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 216594004773 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 216594004774 ligand binding site [chemical binding]; other site 216594004775 active site 216594004776 UGI interface [polypeptide binding]; other site 216594004777 catalytic site [active] 216594004778 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216594004779 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 216594004780 putative NAD(P) binding site [chemical binding]; other site 216594004781 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 216594004782 putative FMN binding site [chemical binding]; other site 216594004783 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 216594004784 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 216594004785 DAK2 domain; Region: Dak2; cl03685 216594004786 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 216594004787 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 216594004788 generic binding surface II; other site 216594004789 ssDNA binding site; other site 216594004790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594004791 ATP binding site [chemical binding]; other site 216594004792 putative Mg++ binding site [ion binding]; other site 216594004793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594004794 nucleotide binding region [chemical binding]; other site 216594004795 ATP-binding site [chemical binding]; other site 216594004796 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 216594004797 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216594004798 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216594004799 active site 216594004800 catalytic tetrad [active] 216594004801 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594004802 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 216594004803 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 216594004804 catalytic residues [active] 216594004805 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 216594004806 putative active site [active] 216594004807 redox center [active] 216594004808 pyruvate carboxylase; Reviewed; Region: PRK12999 216594004809 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216594004810 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216594004811 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216594004812 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 216594004813 active site 216594004814 catalytic residues [active] 216594004815 metal binding site [ion binding]; metal-binding site 216594004816 homodimer binding site [polypeptide binding]; other site 216594004817 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216594004818 carboxyltransferase (CT) interaction site; other site 216594004819 biotinylation site [posttranslational modification]; other site 216594004820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594004821 S-adenosylmethionine binding site [chemical binding]; other site 216594004822 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 216594004823 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 216594004824 active site 216594004825 (T/H)XGH motif; other site 216594004826 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 216594004827 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 216594004828 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 216594004829 putative active site [active] 216594004830 putative substrate binding site [chemical binding]; other site 216594004831 putative cosubstrate binding site; other site 216594004832 catalytic site [active] 216594004833 Predicted permease; Region: DUF318; pfam03773 216594004834 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 216594004835 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 216594004836 active site 216594004837 TDP-binding site; other site 216594004838 acceptor substrate-binding pocket; other site 216594004839 Methyltransferase domain; Region: Methyltransf_24; pfam13578 216594004840 Uncharacterized conserved protein [Function unknown]; Region: COG3268 216594004841 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594004842 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594004843 acyl-CoA synthetase; Validated; Region: PRK05850 216594004844 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594004845 acyl-activating enzyme (AAE) consensus motif; other site 216594004846 active site 216594004847 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 216594004848 acyl-CoA synthetase; Validated; Region: PRK06060 216594004849 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594004850 acyl-activating enzyme (AAE) consensus motif; other site 216594004851 AMP binding site [chemical binding]; other site 216594004852 active site 216594004853 CoA binding site [chemical binding]; other site 216594004854 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594004855 Erythronolide synthase docking; Region: Docking; pfam08990 216594004856 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594004857 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594004858 active site 216594004859 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594004860 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594004861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594004862 Enoylreductase; Region: PKS_ER; smart00829 216594004863 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594004864 NAD(P) binding site [chemical binding]; other site 216594004865 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594004866 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594004867 putative NADP binding site [chemical binding]; other site 216594004868 active site 216594004869 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594004870 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 216594004871 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594004872 acyl-CoA synthetase; Validated; Region: PRK05850 216594004873 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594004874 acyl-activating enzyme (AAE) consensus motif; other site 216594004875 active site 216594004876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594004877 S-adenosylmethionine binding site [chemical binding]; other site 216594004878 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594004879 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594004880 active site 216594004881 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 216594004882 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594004883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594004884 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594004885 Enoylreductase; Region: PKS_ER; smart00829 216594004886 NAD(P) binding site [chemical binding]; other site 216594004887 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 216594004888 KR domain; Region: KR; pfam08659 216594004889 putative NADP binding site [chemical binding]; other site 216594004890 active site 216594004891 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594004892 acyltransferase PapA5; Provisional; Region: PRK09294 216594004893 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 216594004894 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216594004895 ABC-2 type transporter; Region: ABC2_membrane; cl17235 216594004896 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216594004897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594004898 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 216594004899 Walker A/P-loop; other site 216594004900 ATP binding site [chemical binding]; other site 216594004901 Q-loop/lid; other site 216594004902 ABC transporter signature motif; other site 216594004903 Walker B; other site 216594004904 D-loop; other site 216594004905 H-loop/switch region; other site 216594004906 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594004907 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594004908 active site 216594004909 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594004910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594004911 Condensation domain; Region: Condensation; pfam00668 216594004912 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216594004913 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594004914 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594004915 active site 216594004916 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594004917 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594004918 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 216594004919 KR domain; Region: KR; pfam08659 216594004920 putative NADP binding site [chemical binding]; other site 216594004921 active site 216594004922 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594004923 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594004924 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594004925 active site 216594004926 Acyl transferase domain; Region: Acyl_transf_1; cl08282 216594004927 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594004928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594004929 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594004930 Enoylreductase; Region: PKS_ER; smart00829 216594004931 NAD(P) binding site [chemical binding]; other site 216594004932 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 216594004933 KR domain; Region: KR; pfam08659 216594004934 putative NADP binding site [chemical binding]; other site 216594004935 active site 216594004936 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594004937 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594004938 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 216594004939 active site 216594004940 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594004941 Acyl transferase domain; Region: Acyl_transf_1; cl08282 216594004942 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 216594004943 KR domain; Region: KR; pfam08659 216594004944 putative NADP binding site [chemical binding]; other site 216594004945 active site 216594004946 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594004947 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594004948 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594004949 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 216594004950 active site 216594004951 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594004952 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 216594004953 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 216594004954 KR domain; Region: KR; pfam08659 216594004955 NADP binding site [chemical binding]; other site 216594004956 active site 216594004957 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594004958 acyl-CoA synthetase; Validated; Region: PRK05850 216594004959 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594004960 acyl-activating enzyme (AAE) consensus motif; other site 216594004961 active site 216594004962 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 216594004963 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 216594004964 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 216594004965 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 216594004966 ribonuclease III; Reviewed; Region: rnc; PRK00102 216594004967 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 216594004968 dimerization interface [polypeptide binding]; other site 216594004969 active site 216594004970 metal binding site [ion binding]; metal-binding site 216594004971 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 216594004972 dsRNA binding site [nucleotide binding]; other site 216594004973 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 216594004974 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 216594004975 DNA binding site [nucleotide binding] 216594004976 catalytic residue [active] 216594004977 H2TH interface [polypeptide binding]; other site 216594004978 putative catalytic residues [active] 216594004979 turnover-facilitating residue; other site 216594004980 intercalation triad [nucleotide binding]; other site 216594004981 8OG recognition residue [nucleotide binding]; other site 216594004982 putative reading head residues; other site 216594004983 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 216594004984 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216594004985 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 216594004986 acylphosphatase; Provisional; Region: PRK14422 216594004987 RecF/RecN/SMC N terminal domain; Region: SMC_N; pfam02463 216594004988 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 216594004989 Walker A/P-loop; other site 216594004990 ATP binding site [chemical binding]; other site 216594004991 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 216594004992 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 216594004993 ABC transporter signature motif; other site 216594004994 Walker B; other site 216594004995 D-loop; other site 216594004996 H-loop/switch region; other site 216594004997 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 216594004998 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 216594004999 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216594005000 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 216594005001 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 216594005002 Nitrogen regulatory protein P-II; Region: P-II; smart00938 216594005003 PII uridylyl-transferase; Provisional; Region: PRK03381 216594005004 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216594005005 metal binding triad; other site 216594005006 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216594005007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 216594005008 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 216594005009 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 216594005010 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 216594005011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594005012 ATP binding site [chemical binding]; other site 216594005013 putative Mg++ binding site [ion binding]; other site 216594005014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 216594005015 ATP-binding site [chemical binding]; other site 216594005016 signal recognition particle protein; Provisional; Region: PRK10867 216594005017 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 216594005018 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 216594005019 P loop; other site 216594005020 GTP binding site [chemical binding]; other site 216594005021 Signal peptide binding domain; Region: SRP_SPB; pfam02978 216594005022 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 216594005023 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 216594005024 active site 216594005025 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 216594005026 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594005027 active site 216594005028 substrate binding site [chemical binding]; other site 216594005029 ATP binding site [chemical binding]; other site 216594005030 activation loop (A-loop); other site 216594005031 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 216594005032 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594005033 active site 216594005034 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594005035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594005036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594005037 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 216594005038 SnoaL-like domain; Region: SnoaL_4; pfam13577 216594005039 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 216594005040 hypothetical protein; Provisional; Region: PRK02821 216594005041 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 216594005042 G-X-X-G motif; other site 216594005043 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 216594005044 RimM N-terminal domain; Region: RimM; pfam01782 216594005045 PRC-barrel domain; Region: PRC; pfam05239 216594005046 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 216594005047 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216594005048 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 216594005049 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 216594005050 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216594005051 Catalytic site [active] 216594005052 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216594005053 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 216594005054 RNA/DNA hybrid binding site [nucleotide binding]; other site 216594005055 active site 216594005056 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 216594005057 ANTAR domain; Region: ANTAR; pfam03861 216594005058 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594005059 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594005060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594005061 NAD(P) binding site [chemical binding]; other site 216594005062 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216594005063 active site 216594005064 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 216594005065 hypothetical protein; Reviewed; Region: PRK12497 216594005066 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 216594005067 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 216594005068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594005069 Walker A motif; other site 216594005070 ATP binding site [chemical binding]; other site 216594005071 Walker B motif; other site 216594005072 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 216594005073 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 216594005074 DNA protecting protein DprA; Region: dprA; TIGR00732 216594005075 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 216594005076 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 216594005077 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 216594005078 FAD binding pocket [chemical binding]; other site 216594005079 FAD binding motif [chemical binding]; other site 216594005080 phosphate binding motif [ion binding]; other site 216594005081 NAD binding pocket [chemical binding]; other site 216594005082 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 216594005083 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 216594005084 putative active site [active] 216594005085 putative substrate binding site [chemical binding]; other site 216594005086 putative FMN binding site [chemical binding]; other site 216594005087 putative catalytic residues [active] 216594005088 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 216594005089 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594005090 active site 216594005091 DNA binding site [nucleotide binding] 216594005092 Int/Topo IB signature motif; other site 216594005093 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216594005094 Peptidase family M23; Region: Peptidase_M23; pfam01551 216594005095 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 216594005096 rRNA interaction site [nucleotide binding]; other site 216594005097 S8 interaction site; other site 216594005098 putative laminin-1 binding site; other site 216594005099 elongation factor Ts; Provisional; Region: tsf; PRK09377 216594005100 UBA/TS-N domain; Region: UBA; pfam00627 216594005101 Elongation factor TS; Region: EF_TS; pfam00889 216594005102 Elongation factor TS; Region: EF_TS; pfam00889 216594005103 amidase; Provisional; Region: PRK07869 216594005104 Amidase; Region: Amidase; pfam01425 216594005105 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216594005106 MarR family; Region: MarR; pfam01047 216594005107 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 216594005108 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594005109 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 216594005110 putative acyl-acceptor binding pocket; other site 216594005111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594005112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594005113 DNA binding site [nucleotide binding] 216594005114 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 216594005115 putative nucleotide binding site [chemical binding]; other site 216594005116 uridine monophosphate binding site [chemical binding]; other site 216594005117 homohexameric interface [polypeptide binding]; other site 216594005118 ribosome recycling factor; Reviewed; Region: frr; PRK00083 216594005119 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 216594005120 hinge region; other site 216594005121 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 216594005122 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 216594005123 MURD40; Contains a single CDS encoding a large PE-PGRS family protein 216594005124 PE family; Region: PE; pfam00934 216594005125 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 216594005126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594005127 FeS/SAM binding site; other site 216594005128 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216594005129 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216594005130 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 216594005131 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 216594005132 Fasciclin domain; Region: Fasciclin; pfam02469 216594005133 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 216594005134 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 216594005135 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 216594005136 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216594005137 catalytic residues [active] 216594005138 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 216594005139 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 216594005140 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 216594005141 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 216594005142 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 216594005143 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216594005144 active site 216594005145 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 216594005146 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 216594005147 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 216594005148 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 216594005149 Predicted acetyltransferase [General function prediction only]; Region: COG3393 216594005150 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 216594005151 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 216594005152 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 216594005153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216594005154 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 216594005155 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 216594005156 active site 216594005157 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594005158 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 216594005159 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 216594005160 catalytic triad [active] 216594005161 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594005162 PPE family; Region: PPE; pfam00823 216594005163 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594005164 PPE family; Region: PPE; pfam00823 216594005165 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594005166 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594005167 PPE family; Region: PPE; pfam00823 216594005168 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594005169 PE family; Region: PE; pfam00934 216594005170 MURD41; Contains two CDS encoding PE-PGRS family proteins and bioF2_3, encoding an enzyme involved in biotin biosynthesis 216594005171 PE family; Region: PE; pfam00934 216594005172 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 216594005173 hypothetical protein; Provisional; Region: PRK07505 216594005174 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594005175 catalytic residue [active] 216594005176 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 216594005177 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 216594005178 MURD42; Contains a nickel/iron-hydrogenase synthesis locus. Also harbours mtr, encoding mycothiol reductase. This gene is essential in MTB yet is absent from M. ulcerans. This MURD also contains a long-chain acyl-CoA synthetase and a MmpL family protein 216594005179 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 216594005180 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 216594005181 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 216594005182 HupF/HypC family; Region: HupF_HypC; pfam01455 216594005183 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 216594005184 dimerization interface [polypeptide binding]; other site 216594005185 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 216594005186 ATP binding site [chemical binding]; other site 216594005187 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 216594005188 dimer interface [polypeptide binding]; other site 216594005189 active site 216594005190 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 216594005191 HupF/HypC family; Region: HupF_HypC; cl00394 216594005192 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 216594005193 Acylphosphatase; Region: Acylphosphatase; cl00551 216594005194 HypF finger; Region: zf-HYPF; pfam07503 216594005195 HypF finger; Region: zf-HYPF; pfam07503 216594005196 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 216594005197 HupF/HypC family; Region: HupF_HypC; pfam01455 216594005198 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 216594005199 nickel binding site [ion binding]; other site 216594005200 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 216594005201 NifU-like domain; Region: NifU; cl00484 216594005202 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 216594005203 [2Fe-2S] cluster binding site [ion binding]; other site 216594005204 iron-sulfur cluster [ion binding]; other site 216594005205 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 216594005206 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 216594005207 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 216594005208 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216594005209 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 216594005210 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 216594005211 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 216594005212 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216594005213 metal binding site 2 [ion binding]; metal-binding site 216594005214 putative DNA binding helix; other site 216594005215 metal binding site 1 [ion binding]; metal-binding site 216594005216 dimer interface [polypeptide binding]; other site 216594005217 structural Zn2+ binding site [ion binding]; other site 216594005218 mycothione reductase; Reviewed; Region: PRK07846 216594005219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594005220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594005221 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216594005222 acyl-CoA synthetase; Validated; Region: PRK05850 216594005223 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594005224 acyl-activating enzyme (AAE) consensus motif; other site 216594005225 active site 216594005226 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594005227 Thioesterase; Region: PKS_TE; smart00824 216594005228 Transport protein; Region: actII; TIGR00833 216594005229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594005230 putative substrate translocation pore; other site 216594005231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594005232 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216594005233 malate:quinone oxidoreductase; Validated; Region: PRK05257 216594005234 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 216594005235 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 216594005236 Coenzyme A binding pocket [chemical binding]; other site 216594005237 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 216594005238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 216594005239 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 216594005240 metal ion-dependent adhesion site (MIDAS); other site 216594005241 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 216594005242 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 216594005243 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 216594005244 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 216594005245 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 216594005246 catalytic triad [active] 216594005247 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 216594005248 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 216594005249 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 216594005250 active site 216594005251 SAM binding site [chemical binding]; other site 216594005252 homodimer interface [polypeptide binding]; other site 216594005253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594005254 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594005255 putative substrate translocation pore; other site 216594005256 prolyl-tRNA synthetase; Provisional; Region: PRK09194 216594005257 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 216594005258 dimer interface [polypeptide binding]; other site 216594005259 motif 1; other site 216594005260 active site 216594005261 motif 2; other site 216594005262 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 216594005263 putative deacylase active site [active] 216594005264 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216594005265 active site 216594005266 motif 3; other site 216594005267 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 216594005268 anticodon binding site; other site 216594005269 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 216594005270 dinuclear metal binding motif [ion binding]; other site 216594005271 ribosome maturation protein RimP; Reviewed; Region: PRK00092 216594005272 Sm and related proteins; Region: Sm_like; cl00259 216594005273 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 216594005274 putative oligomer interface [polypeptide binding]; other site 216594005275 putative RNA binding site [nucleotide binding]; other site 216594005276 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 216594005277 NusA N-terminal domain; Region: NusA_N; pfam08529 216594005278 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 216594005279 RNA binding site [nucleotide binding]; other site 216594005280 homodimer interface [polypeptide binding]; other site 216594005281 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 216594005282 G-X-X-G motif; other site 216594005283 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 216594005284 G-X-X-G motif; other site 216594005285 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 216594005286 putative RNA binding cleft [nucleotide binding]; other site 216594005287 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 216594005288 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 216594005289 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 216594005290 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 216594005291 G1 box; other site 216594005292 putative GEF interaction site [polypeptide binding]; other site 216594005293 GTP/Mg2+ binding site [chemical binding]; other site 216594005294 Switch I region; other site 216594005295 G2 box; other site 216594005296 G3 box; other site 216594005297 Switch II region; other site 216594005298 G4 box; other site 216594005299 G5 box; other site 216594005300 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 216594005301 Translation-initiation factor 2; Region: IF-2; pfam11987 216594005302 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 216594005303 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 216594005304 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 216594005305 DHH family; Region: DHH; pfam01368 216594005306 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 216594005307 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 216594005308 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216594005309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594005310 dimer interface [polypeptide binding]; other site 216594005311 conserved gate region; other site 216594005312 putative PBP binding loops; other site 216594005313 ABC-ATPase subunit interface; other site 216594005314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216594005315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594005316 dimer interface [polypeptide binding]; other site 216594005317 conserved gate region; other site 216594005318 putative PBP binding loops; other site 216594005319 ABC-ATPase subunit interface; other site 216594005320 MURD43; function Unknown function; overlaps CDS encoding three ABC transporters, a putative thioredoxin reductase, enoyl coA hydratase and a PPE family protein 216594005321 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216594005322 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216594005323 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216594005324 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216594005325 Walker A/P-loop; other site 216594005326 ATP binding site [chemical binding]; other site 216594005327 Q-loop/lid; other site 216594005328 ABC transporter signature motif; other site 216594005329 Walker B; other site 216594005330 D-loop; other site 216594005331 H-loop/switch region; other site 216594005332 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 216594005333 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 216594005334 enoyl-CoA hydratase; Provisional; Region: PRK06190 216594005335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594005336 substrate binding site [chemical binding]; other site 216594005337 oxyanion hole (OAH) forming residues; other site 216594005338 trimer interface [polypeptide binding]; other site 216594005339 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594005340 PPE family; Region: PPE; pfam00823 216594005341 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594005342 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594005343 PPE family; Region: PPE; pfam00823 216594005344 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594005345 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 216594005346 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 216594005347 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 216594005348 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 216594005349 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 216594005350 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 216594005351 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 216594005352 sugar binding site [chemical binding]; other site 216594005353 Predicted acyl esterases [General function prediction only]; Region: COG2936 216594005354 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594005355 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 216594005356 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 216594005357 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 216594005358 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 216594005359 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216594005360 active site 216594005361 metal binding site [ion binding]; metal-binding site 216594005362 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 216594005363 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 216594005364 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 216594005365 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 216594005366 RNA binding site [nucleotide binding]; other site 216594005367 active site 216594005368 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 216594005369 lipid-transfer protein; Provisional; Region: PRK08256 216594005370 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594005371 active site 216594005372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594005373 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594005374 active site 216594005375 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 216594005376 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594005377 putative DNA binding site [nucleotide binding]; other site 216594005378 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 216594005379 FeoA domain; Region: FeoA; pfam04023 216594005380 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 216594005381 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 216594005382 active site 216594005383 Riboflavin kinase; Region: Flavokinase; pfam01687 216594005384 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 216594005385 16S/18S rRNA binding site [nucleotide binding]; other site 216594005386 S13e-L30e interaction site [polypeptide binding]; other site 216594005387 25S rRNA binding site [nucleotide binding]; other site 216594005388 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 216594005389 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 216594005390 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 216594005391 oligomer interface [polypeptide binding]; other site 216594005392 RNA binding site [nucleotide binding]; other site 216594005393 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 216594005394 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 216594005395 RNase E interface [polypeptide binding]; other site 216594005396 trimer interface [polypeptide binding]; other site 216594005397 active site 216594005398 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 216594005399 putative nucleic acid binding region [nucleotide binding]; other site 216594005400 G-X-X-G motif; other site 216594005401 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 216594005402 RNA binding site [nucleotide binding]; other site 216594005403 domain interface; other site 216594005404 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216594005405 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216594005406 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216594005407 Nitronate monooxygenase; Region: NMO; pfam03060 216594005408 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216594005409 FMN binding site [chemical binding]; other site 216594005410 substrate binding site [chemical binding]; other site 216594005411 putative catalytic residue [active] 216594005412 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 216594005413 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 216594005414 hexamer interface [polypeptide binding]; other site 216594005415 ligand binding site [chemical binding]; other site 216594005416 putative active site [active] 216594005417 NAD(P) binding site [chemical binding]; other site 216594005418 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 216594005419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594005420 putative DNA binding site [nucleotide binding]; other site 216594005421 putative Zn2+ binding site [ion binding]; other site 216594005422 AsnC family; Region: AsnC_trans_reg; pfam01037 216594005423 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216594005424 hydrophobic ligand binding site; other site 216594005425 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 216594005426 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 216594005427 short chain dehydrogenase; Validated; Region: PRK05855 216594005428 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594005429 classical (c) SDRs; Region: SDR_c; cd05233 216594005430 NAD(P) binding site [chemical binding]; other site 216594005431 active site 216594005432 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216594005433 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 216594005434 FMN-binding pocket [chemical binding]; other site 216594005435 flavin binding motif; other site 216594005436 phosphate binding motif [ion binding]; other site 216594005437 beta-alpha-beta structure motif; other site 216594005438 NAD binding pocket [chemical binding]; other site 216594005439 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594005440 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216594005441 catalytic loop [active] 216594005442 iron binding site [ion binding]; other site 216594005443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594005444 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594005445 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216594005446 [2Fe-2S] cluster binding site [ion binding]; other site 216594005447 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216594005448 hydrophobic ligand binding site; other site 216594005449 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 216594005450 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216594005451 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594005452 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594005453 active site 216594005454 dihydrodipicolinate reductase; Provisional; Region: PRK00048 216594005455 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216594005456 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 216594005457 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 216594005458 MURD44; function Unknown function, overlaps CDS encoding hypothetical proteins of unknown function one of which may be membrane-associated 216594005459 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 216594005460 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216594005461 Fic family protein [Function unknown]; Region: COG3177 216594005462 Fic/DOC family; Region: Fic; pfam02661 216594005463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 216594005464 Uncharacterized conserved protein [Function unknown]; Region: COG5323 216594005465 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594005466 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594005467 PPE family; Region: PPE; pfam00823 216594005468 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594005469 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594005470 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594005471 acyl-activating enzyme (AAE) consensus motif; other site 216594005472 AMP binding site [chemical binding]; other site 216594005473 active site 216594005474 CoA binding site [chemical binding]; other site 216594005475 PE family; Region: PE; pfam00934 216594005476 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594005477 MURD45; Overlaps a PE and PPE protein 216594005478 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594005479 PPE family; Region: PPE; pfam00823 216594005480 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594005481 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 216594005482 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216594005483 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216594005484 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 216594005485 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216594005486 carboxyltransferase (CT) interaction site; other site 216594005487 biotinylation site [posttranslational modification]; other site 216594005488 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216594005489 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 216594005490 classical (c) SDRs; Region: SDR_c; cd05233 216594005491 NAD(P) binding site [chemical binding]; other site 216594005492 active site 216594005493 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594005494 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594005495 active site 216594005496 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594005497 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594005498 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594005499 active site 216594005500 Dienelactone hydrolase family; Region: DLH; pfam01738 216594005501 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594005502 thymidylate synthase; Reviewed; Region: thyA; PRK01827 216594005503 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 216594005504 dimerization interface [polypeptide binding]; other site 216594005505 active site 216594005506 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 216594005507 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 216594005508 folate binding site [chemical binding]; other site 216594005509 NADP+ binding site [chemical binding]; other site 216594005510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 216594005511 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 216594005512 HsdM N-terminal domain; Region: HsdM_N; pfam12161 216594005513 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 216594005514 Methyltransferase domain; Region: Methyltransf_26; pfam13659 216594005515 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 216594005516 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 216594005517 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 216594005518 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216594005519 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 216594005520 dimer interface [polypeptide binding]; other site 216594005521 active site 216594005522 catalytic residue [active] 216594005523 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 216594005524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594005525 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 216594005526 MURD46; Overlaps a CDS encoding a hypothetical hydrolase 216594005527 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594005528 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594005529 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 216594005530 classical (c) SDRs; Region: SDR_c; cd05233 216594005531 NAD(P) binding site [chemical binding]; other site 216594005532 active site 216594005533 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216594005534 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 216594005535 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 216594005536 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594005537 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 216594005538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594005539 Coenzyme A binding pocket [chemical binding]; other site 216594005540 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 216594005541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594005542 non-specific DNA binding site [nucleotide binding]; other site 216594005543 salt bridge; other site 216594005544 sequence-specific DNA binding site [nucleotide binding]; other site 216594005545 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 216594005546 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 216594005547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216594005548 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 216594005549 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 216594005550 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 216594005551 recombinase A; Provisional; Region: recA; PRK09354 216594005552 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 216594005553 hexamer interface [polypeptide binding]; other site 216594005554 Walker A motif; other site 216594005555 ATP binding site [chemical binding]; other site 216594005556 Walker B motif; other site 216594005557 recombination regulator RecX; Reviewed; Region: recX; PRK00117 216594005558 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 216594005559 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216594005560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594005561 FeS/SAM binding site; other site 216594005562 TRAM domain; Region: TRAM; cl01282 216594005563 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 216594005564 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 216594005565 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 216594005566 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594005567 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594005568 active site 216594005569 ATP binding site [chemical binding]; other site 216594005570 substrate binding site [chemical binding]; other site 216594005571 activation loop (A-loop); other site 216594005572 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 216594005573 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 216594005574 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 216594005575 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 216594005576 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 216594005577 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 216594005578 GTPases [General function prediction only]; Region: HflX; COG2262 216594005579 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 216594005580 HflX GTPase family; Region: HflX; cd01878 216594005581 G1 box; other site 216594005582 GTP/Mg2+ binding site [chemical binding]; other site 216594005583 Switch I region; other site 216594005584 G2 box; other site 216594005585 G3 box; other site 216594005586 Switch II region; other site 216594005587 G4 box; other site 216594005588 G5 box; other site 216594005589 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594005590 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594005591 active site 216594005592 Integral membrane protein TerC family; Region: TerC; cl10468 216594005593 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 216594005594 LGFP repeat; Region: LGFP; pfam08310 216594005595 LGFP repeat; Region: LGFP; pfam08310 216594005596 LGFP repeat; Region: LGFP; pfam08310 216594005597 LGFP repeat; Region: LGFP; pfam08310 216594005598 LGFP repeat; Region: LGFP; pfam08310 216594005599 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 216594005600 LexA repressor; Validated; Region: PRK00215 216594005601 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 216594005602 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216594005603 Catalytic site [active] 216594005604 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 216594005605 ATP cone domain; Region: ATP-cone; pfam03477 216594005606 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 216594005607 heme-binding site [chemical binding]; other site 216594005608 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 216594005609 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594005610 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 216594005611 PAC2 family; Region: PAC2; pfam09754 216594005612 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 216594005613 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 216594005614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594005615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594005616 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216594005617 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 216594005618 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 216594005619 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 216594005620 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 216594005621 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 216594005622 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 216594005623 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216594005624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594005625 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216594005626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594005627 DNA binding residues [nucleotide binding] 216594005628 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 216594005629 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 216594005630 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 216594005631 Protein of unknown function (DUF952); Region: DUF952; cl01393 216594005632 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 216594005633 homotrimer interaction site [polypeptide binding]; other site 216594005634 putative active site [active] 216594005635 PE family; Region: PE; pfam00934 216594005636 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 216594005637 active site 216594005638 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 216594005639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594005640 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216594005641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594005642 DNA binding residues [nucleotide binding] 216594005643 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216594005644 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216594005645 nucleotide binding site [chemical binding]; other site 216594005646 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 216594005647 active site 216594005648 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216594005649 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 216594005650 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 216594005651 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 216594005652 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216594005653 trimer interface [polypeptide binding]; other site 216594005654 active site 216594005655 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 216594005656 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 216594005657 generic binding surface II; other site 216594005658 ssDNA binding site; other site 216594005659 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 216594005660 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 216594005661 TrkA-N domain; Region: TrkA_N; pfam02254 216594005662 TrkA-C domain; Region: TrkA_C; pfam02080 216594005663 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 216594005664 TrkA-N domain; Region: TrkA_N; pfam02254 216594005665 TrkA-C domain; Region: TrkA_C; pfam02080 216594005666 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216594005667 TRAM domain; Region: TRAM; cl01282 216594005668 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 216594005669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216594005670 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216594005671 Walker A/P-loop; other site 216594005672 ATP binding site [chemical binding]; other site 216594005673 Q-loop/lid; other site 216594005674 ABC transporter signature motif; other site 216594005675 Walker B; other site 216594005676 D-loop; other site 216594005677 H-loop/switch region; other site 216594005678 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 216594005679 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 216594005680 transmembrane helices; other site 216594005681 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 216594005682 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 216594005683 transmembrane helices; other site 216594005684 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 216594005685 FOG: CBS domain [General function prediction only]; Region: COG0517 216594005686 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 216594005687 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 216594005688 TPP-binding site; other site 216594005689 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216594005690 PYR/PP interface [polypeptide binding]; other site 216594005691 dimer interface [polypeptide binding]; other site 216594005692 TPP binding site [chemical binding]; other site 216594005693 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216594005694 PE family; Region: PE; pfam00934 216594005695 MURD47; Overlaps a single PE-PGRS family gene 216594005696 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 216594005697 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 216594005698 catalytic site [active] 216594005699 putative active site [active] 216594005700 putative substrate binding site [chemical binding]; other site 216594005701 Helicase and RNase D C-terminal; Region: HRDC; smart00341 216594005702 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 216594005703 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594005704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594005705 substrate binding site [chemical binding]; other site 216594005706 oxyanion hole (OAH) forming residues; other site 216594005707 trimer interface [polypeptide binding]; other site 216594005708 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 216594005709 substrate binding site [chemical binding]; other site 216594005710 active site 216594005711 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 216594005712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594005713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594005714 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 216594005715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594005716 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594005717 S-adenosylmethionine binding site [chemical binding]; other site 216594005718 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 216594005719 SelR domain; Region: SelR; pfam01641 216594005720 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 216594005721 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594005722 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594005723 hypothetical protein; Provisional; Region: PRK14059 216594005724 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 216594005725 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 216594005726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594005727 Coenzyme A binding pocket [chemical binding]; other site 216594005728 Clp protease ATP binding subunit; Region: clpC; CHL00095 216594005729 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594005730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594005731 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594005732 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594005733 TPR repeat; Region: TPR_11; pfam13414 216594005734 Tetratricopeptide repeat; Region: TPR_2; pfam07719 216594005735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216594005736 binding surface 216594005737 TPR motif; other site 216594005738 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216594005739 PE family; Region: PE; pfam00934 216594005740 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 216594005741 arsenical-resistance protein; Region: acr3; TIGR00832 216594005742 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 216594005743 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216594005744 active site 216594005745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594005746 dimerization interface [polypeptide binding]; other site 216594005747 putative DNA binding site [nucleotide binding]; other site 216594005748 putative Zn2+ binding site [ion binding]; other site 216594005749 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 216594005750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594005751 putative metal binding site [ion binding]; other site 216594005752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594005753 putative DNA binding site [nucleotide binding]; other site 216594005754 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 216594005755 putative heme binding pocket [chemical binding]; other site 216594005756 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216594005757 anti sigma factor interaction site; other site 216594005758 regulatory phosphorylation site [posttranslational modification]; other site 216594005759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594005760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594005761 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216594005762 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216594005763 acyl-CoA synthetase; Validated; Region: PRK07798 216594005764 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594005765 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 216594005766 acyl-activating enzyme (AAE) consensus motif; other site 216594005767 acyl-activating enzyme (AAE) consensus motif; other site 216594005768 putative AMP binding site [chemical binding]; other site 216594005769 putative active site [active] 216594005770 putative CoA binding site [chemical binding]; other site 216594005771 MURD48; Contains two CDS, one is a putative chloramphenicol 3-O-phosphotransferase 216594005772 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 216594005773 P-loop motif; other site 216594005774 ATP binding site [chemical binding]; other site 216594005775 Chloramphenicol (Cm) binding site [chemical binding]; other site 216594005776 catalytic residue [active] 216594005777 Domain of unknown function (DUF385); Region: DUF385; cl04387 216594005778 PE family; Region: PE; pfam00934 216594005779 MURD49; Overlaps the C-term of a PE-PGRS family gene 216594005780 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 216594005781 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG1926 216594005782 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216594005783 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 216594005784 peptide chain release factor 1; Provisional; Region: PRK04011 216594005785 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216594005786 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 216594005787 acyl-activating enzyme (AAE) consensus motif; other site 216594005788 putative AMP binding site [chemical binding]; other site 216594005789 putative active site [active] 216594005790 putative CoA binding site [chemical binding]; other site 216594005791 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594005792 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594005793 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 216594005794 active site 216594005795 Peptidase family M50; Region: Peptidase_M50; pfam02163 216594005796 putative substrate binding region [chemical binding]; other site 216594005797 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 216594005798 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594005799 Ligand Binding Site [chemical binding]; other site 216594005800 Universal stress protein family; Region: Usp; pfam00582 216594005801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594005802 Ligand Binding Site [chemical binding]; other site 216594005803 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594005804 Ligand Binding Site [chemical binding]; other site 216594005805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594005806 S-adenosylmethionine binding site [chemical binding]; other site 216594005807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594005808 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 216594005809 Ferredoxin [Energy production and conversion]; Region: COG1146 216594005810 4Fe-4S binding domain; Region: Fer4; pfam00037 216594005811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 216594005812 Predicted transcriptional regulator [Transcription]; Region: COG2345 216594005813 putative DNA binding site [nucleotide binding]; other site 216594005814 putative Zn2+ binding site [ion binding]; other site 216594005815 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216594005816 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216594005817 FMN binding site [chemical binding]; other site 216594005818 substrate binding site [chemical binding]; other site 216594005819 putative catalytic residue [active] 216594005820 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 216594005821 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216594005822 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216594005823 active site 216594005824 catalytic tetrad [active] 216594005825 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594005826 CoenzymeA binding site [chemical binding]; other site 216594005827 subunit interaction site [polypeptide binding]; other site 216594005828 PHB binding site; other site 216594005829 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 216594005830 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 216594005831 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 216594005832 active site 216594005833 dimer interface [polypeptide binding]; other site 216594005834 motif 1; other site 216594005835 motif 2; other site 216594005836 motif 3; other site 216594005837 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 216594005838 anticodon binding site; other site 216594005839 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 216594005840 nucleotide binding site/active site [active] 216594005841 HIT family signature motif; other site 216594005842 catalytic residue [active] 216594005843 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 216594005844 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 216594005845 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216594005846 putative acyl-acceptor binding pocket; other site 216594005847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594005848 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216594005849 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 216594005850 nudix motif; other site 216594005851 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 216594005852 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 216594005853 active site 216594005854 multimer interface [polypeptide binding]; other site 216594005855 acyl-CoA thioesterase II; Region: tesB; TIGR00189 216594005856 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 216594005857 active site 216594005858 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 216594005859 catalytic triad [active] 216594005860 dimer interface [polypeptide binding]; other site 216594005861 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 216594005862 predicted active site [active] 216594005863 catalytic triad [active] 216594005864 PE family; Region: PE; pfam00934 216594005865 hypothetical protein; Validated; Region: PRK00110 216594005866 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594005867 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594005868 PE family; Region: PE; pfam00934 216594005869 PE family; Region: PE; pfam00934 216594005870 MURD50; Overlaps two genes encoding PE-PGRS family proteins 216594005871 PE family; Region: PE; pfam00934 216594005872 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 216594005873 spermidine synthase; Provisional; Region: PRK03612 216594005874 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 216594005875 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 216594005876 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 216594005877 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 216594005878 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 216594005879 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 216594005880 active site 216594005881 putative DNA-binding cleft [nucleotide binding]; other site 216594005882 dimer interface [polypeptide binding]; other site 216594005883 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 216594005884 RuvA N terminal domain; Region: RuvA_N; pfam01330 216594005885 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 216594005886 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 216594005887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594005888 Walker A motif; other site 216594005889 ATP binding site [chemical binding]; other site 216594005890 Walker B motif; other site 216594005891 arginine finger; other site 216594005892 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 216594005893 PE family; Region: PE; pfam00934 216594005894 PE family; Region: PE; pfam00934 216594005895 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 216594005896 PE family; Region: PE; pfam00934 216594005897 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216594005898 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594005899 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594005900 acyl-activating enzyme (AAE) consensus motif; other site 216594005901 acyl-activating enzyme (AAE) consensus motif; other site 216594005902 AMP binding site [chemical binding]; other site 216594005903 active site 216594005904 CoA binding site [chemical binding]; other site 216594005905 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594005906 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 216594005907 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 216594005908 putative NAD(P) binding site [chemical binding]; other site 216594005909 active site 216594005910 putative substrate binding site [chemical binding]; other site 216594005911 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 216594005912 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594005913 inhibitor-cofactor binding pocket; inhibition site 216594005914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594005915 catalytic residue [active] 216594005916 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 216594005917 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 216594005918 Protein export membrane protein; Region: SecD_SecF; cl14618 216594005919 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 216594005920 Protein export membrane protein; Region: SecD_SecF; pfam02355 216594005921 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 216594005922 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216594005923 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216594005924 active site 216594005925 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 216594005926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216594005927 Zn2+ binding site [ion binding]; other site 216594005928 Mg2+ binding site [ion binding]; other site 216594005929 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216594005930 synthetase active site [active] 216594005931 NTP binding site [chemical binding]; other site 216594005932 metal binding site [ion binding]; metal-binding site 216594005933 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 216594005934 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 216594005935 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 216594005936 active site 216594005937 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216594005938 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 216594005939 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 216594005940 dimer interface [polypeptide binding]; other site 216594005941 motif 1; other site 216594005942 active site 216594005943 motif 2; other site 216594005944 motif 3; other site 216594005945 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 216594005946 anticodon binding site; other site 216594005947 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594005948 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594005949 bacteriophage phiMmar06; MURD51; Putative prophage or another type of mobile DNA. Harbours CDS encoding an integrase, DNA replication and partioning proteins. Other CDS encode hypothetical proteins and ABC transporters 216594005950 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216594005951 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 216594005952 catalytic residues [active] 216594005953 catalytic nucleophile [active] 216594005954 Recombinase; Region: Recombinase; pfam07508 216594005955 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216594005956 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594005957 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216594005958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594005959 non-specific DNA binding site [nucleotide binding]; other site 216594005960 salt bridge; other site 216594005961 sequence-specific DNA binding site [nucleotide binding]; other site 216594005962 Cation efflux family; Region: Cation_efflux; cl00316 216594005963 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 216594005964 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 216594005965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594005966 dimerization interface [polypeptide binding]; other site 216594005967 putative DNA binding site [nucleotide binding]; other site 216594005968 putative Zn2+ binding site [ion binding]; other site 216594005969 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 216594005970 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216594005971 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594005972 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594005973 Predicted membrane protein [Function unknown]; Region: COG3619 216594005974 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 216594005975 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 216594005976 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 216594005977 putative active site [active] 216594005978 putative metal binding site [ion binding]; other site 216594005979 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216594005980 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 216594005981 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216594005982 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594005983 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594005984 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 216594005985 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 216594005986 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216594005987 active site 216594005988 metal binding site [ion binding]; metal-binding site 216594005989 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216594005990 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 216594005991 active site 216594005992 nucleophile elbow; other site 216594005993 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216594005994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594005995 non-specific DNA binding site [nucleotide binding]; other site 216594005996 salt bridge; other site 216594005997 sequence-specific DNA binding site [nucleotide binding]; other site 216594005998 Cupin domain; Region: Cupin_2; pfam07883 216594005999 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 216594006000 intersubunit interface [polypeptide binding]; other site 216594006001 active site 216594006002 Zn2+ binding site [ion binding]; other site 216594006003 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216594006004 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216594006005 inhibitor site; inhibition site 216594006006 active site 216594006007 dimer interface [polypeptide binding]; other site 216594006008 catalytic residue [active] 216594006009 Predicted metalloprotease [General function prediction only]; Region: COG2321 216594006010 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 216594006011 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 216594006012 putative hydrophobic ligand binding site [chemical binding]; other site 216594006013 protein interface [polypeptide binding]; other site 216594006014 gate; other site 216594006015 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 216594006016 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 216594006017 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 216594006018 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 216594006019 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 216594006020 dimer interface [polypeptide binding]; other site 216594006021 anticodon binding site; other site 216594006022 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 216594006023 homodimer interface [polypeptide binding]; other site 216594006024 motif 1; other site 216594006025 active site 216594006026 motif 2; other site 216594006027 GAD domain; Region: GAD; pfam02938 216594006028 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216594006029 active site 216594006030 motif 3; other site 216594006031 Domain of unknown function (DUF385); Region: DUF385; pfam04075 216594006032 Predicted membrane protein [Function unknown]; Region: COG4129 216594006033 Protein of unknown function (DUF419); Region: DUF419; cl15265 216594006034 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216594006035 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216594006036 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216594006037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 216594006038 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 216594006039 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 216594006040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 216594006041 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 216594006042 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216594006043 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216594006044 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216594006045 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 216594006046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 216594006047 MURD52; Overlaps a CDS encoding a putative transglutaminase (cysteine protease). This deletion in MU has caused an in- frame deletion 216594006048 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 216594006049 recombination factor protein RarA; Reviewed; Region: PRK13342 216594006050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594006051 Walker A motif; other site 216594006052 ATP binding site [chemical binding]; other site 216594006053 Walker B motif; other site 216594006054 arginine finger; other site 216594006055 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 216594006056 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 216594006057 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 216594006058 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 216594006059 motif 1; other site 216594006060 active site 216594006061 motif 2; other site 216594006062 motif 3; other site 216594006063 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 216594006064 DHHA1 domain; Region: DHHA1; pfam02272 216594006065 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 216594006066 YceG-like family; Region: YceG; pfam02618 216594006067 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 216594006068 dimerization interface [polypeptide binding]; other site 216594006069 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 216594006070 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216594006071 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216594006072 shikimate binding site; other site 216594006073 NAD(P) binding site [chemical binding]; other site 216594006074 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 216594006075 chorismate synthase; Validated; Region: PRK05382 216594006076 Tetramer interface [polypeptide binding]; other site 216594006077 active site 216594006078 FMN-binding site [chemical binding]; other site 216594006079 shikimate kinase; Reviewed; Region: aroK; PRK00131 216594006080 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 216594006081 ADP binding site [chemical binding]; other site 216594006082 magnesium binding site [ion binding]; other site 216594006083 putative shikimate binding site; other site 216594006084 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 216594006085 active site 216594006086 dimer interface [polypeptide binding]; other site 216594006087 metal binding site [ion binding]; metal-binding site 216594006088 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 216594006089 Dehydroquinase class II; Region: DHquinase_II; pfam01220 216594006090 trimer interface [polypeptide binding]; other site 216594006091 active site 216594006092 dimer interface [polypeptide binding]; other site 216594006093 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216594006094 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216594006095 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 216594006096 active site 216594006097 elongation factor P; Validated; Region: PRK00529 216594006098 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 216594006099 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 216594006100 RNA binding site [nucleotide binding]; other site 216594006101 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 216594006102 RNA binding site [nucleotide binding]; other site 216594006103 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 216594006104 putative RNA binding site [nucleotide binding]; other site 216594006105 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 216594006106 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594006107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594006108 catalytic residue [active] 216594006109 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 216594006110 hypothetical protein; Provisional; Region: PRK07236 216594006111 hypothetical protein; Provisional; Region: PRK07588 216594006112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216594006113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216594006114 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594006115 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594006116 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 216594006117 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 216594006118 Fatty acid desaturase; Region: FA_desaturase; pfam00487 216594006119 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 216594006120 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 216594006121 malonyl-CoA binding site [chemical binding]; other site 216594006122 dimer interface [polypeptide binding]; other site 216594006123 active site 216594006124 product binding site; other site 216594006125 sulfotransferase; Region: PLN02164 216594006126 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 216594006127 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 216594006128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006129 S-adenosylmethionine binding site [chemical binding]; other site 216594006130 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 216594006131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216594006132 active site 216594006133 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 216594006134 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216594006135 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216594006136 dihydroorotase; Validated; Region: pyrC; PRK09357 216594006137 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594006138 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 216594006139 active site 216594006140 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 216594006141 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 216594006142 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 216594006143 catalytic site [active] 216594006144 subunit interface [polypeptide binding]; other site 216594006145 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 216594006146 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216594006147 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216594006148 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 216594006149 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216594006150 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216594006151 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 216594006152 IMP binding site; other site 216594006153 dimer interface [polypeptide binding]; other site 216594006154 interdomain contacts; other site 216594006155 partial ornithine binding site; other site 216594006156 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 216594006157 active site 216594006158 dimer interface [polypeptide binding]; other site 216594006159 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 216594006160 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 216594006161 catalytic site [active] 216594006162 G-X2-G-X-G-K; other site 216594006163 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 216594006164 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 216594006165 Flavoprotein; Region: Flavoprotein; pfam02441 216594006166 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 216594006167 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 216594006168 S-adenosylmethionine synthetase; Validated; Region: PRK05250 216594006169 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 216594006170 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 216594006171 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 216594006172 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594006173 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594006174 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594006175 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594006176 substrate binding pocket [chemical binding]; other site 216594006177 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594006178 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594006179 substrate binding pocket [chemical binding]; other site 216594006180 Predicted membrane protein [Function unknown]; Region: COG3714 216594006181 primosome assembly protein PriA; Provisional; Region: PRK14873 216594006182 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 216594006183 Methyltransferase domain; Region: Methyltransf_11; pfam08241 216594006184 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216594006185 MarR family; Region: MarR; pfam01047 216594006186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006187 S-adenosylmethionine binding site [chemical binding]; other site 216594006188 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 216594006189 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 216594006190 putative active site [active] 216594006191 substrate binding site [chemical binding]; other site 216594006192 putative cosubstrate binding site; other site 216594006193 catalytic site [active] 216594006194 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 216594006195 substrate binding site [chemical binding]; other site 216594006196 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 216594006197 putative RNA binding site [nucleotide binding]; other site 216594006198 16S rRNA methyltransferase B; Provisional; Region: PRK14902 216594006199 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 216594006200 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 216594006201 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 216594006202 substrate binding site [chemical binding]; other site 216594006203 hexamer interface [polypeptide binding]; other site 216594006204 metal binding site [ion binding]; metal-binding site 216594006205 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 216594006206 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 216594006207 catalytic motif [active] 216594006208 Zn binding site [ion binding]; other site 216594006209 RibD C-terminal domain; Region: RibD_C; pfam01872 216594006210 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594006211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594006212 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 216594006213 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 216594006214 Lumazine binding domain; Region: Lum_binding; pfam00677 216594006215 Lumazine binding domain; Region: Lum_binding; pfam00677 216594006216 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 216594006217 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 216594006218 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 216594006219 dimerization interface [polypeptide binding]; other site 216594006220 active site 216594006221 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 216594006222 homopentamer interface [polypeptide binding]; other site 216594006223 active site 216594006224 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 216594006225 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594006226 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594006227 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594006228 active site 216594006229 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 216594006230 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 216594006231 GIY-YIG motif/motif A; other site 216594006232 active site 216594006233 catalytic site [active] 216594006234 putative DNA binding site [nucleotide binding]; other site 216594006235 metal binding site [ion binding]; metal-binding site 216594006236 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 216594006237 Helix-hairpin-helix motif; Region: HHH; pfam00633 216594006238 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 216594006239 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 216594006240 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 216594006241 phosphate binding site [ion binding]; other site 216594006242 putative substrate binding pocket [chemical binding]; other site 216594006243 dimer interface [polypeptide binding]; other site 216594006244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 216594006245 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 216594006246 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594006247 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594006248 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594006249 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594006250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594006251 acyl-CoA synthetase; Provisional; Region: PRK13382 216594006252 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594006253 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 216594006254 acyl-activating enzyme (AAE) consensus motif; other site 216594006255 putative AMP binding site [chemical binding]; other site 216594006256 putative active site [active] 216594006257 putative CoA binding site [chemical binding]; other site 216594006258 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594006259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 216594006260 putative acyl-acceptor binding pocket; other site 216594006261 PE family; Region: PE; pfam00934 216594006262 PE-PPE domain; Region: PE-PPE; pfam08237 216594006263 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 216594006264 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216594006265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594006266 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 216594006267 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 216594006268 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216594006269 Phosphoglycerate kinase; Region: PGK; pfam00162 216594006270 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 216594006271 substrate binding site [chemical binding]; other site 216594006272 hinge regions; other site 216594006273 ADP binding site [chemical binding]; other site 216594006274 catalytic site [active] 216594006275 triosephosphate isomerase; Provisional; Region: PRK14567 216594006276 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 216594006277 substrate binding site [chemical binding]; other site 216594006278 dimer interface [polypeptide binding]; other site 216594006279 catalytic triad [active] 216594006280 hypothetical protein; Provisional; Region: PRK06149 216594006281 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216594006282 active site 216594006283 ATP binding site [chemical binding]; other site 216594006284 substrate binding site [chemical binding]; other site 216594006285 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594006286 inhibitor-cofactor binding pocket; inhibition site 216594006287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594006288 catalytic residue [active] 216594006289 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216594006290 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216594006291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594006292 DNA-binding site [nucleotide binding]; DNA binding site 216594006293 FCD domain; Region: FCD; pfam07729 216594006294 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 216594006295 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 216594006296 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 216594006297 PE family; Region: PE; pfam00934 216594006298 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 216594006299 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 216594006300 putative active site [active] 216594006301 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 216594006302 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 216594006303 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 216594006304 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 216594006305 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 216594006306 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 216594006307 putative active site [active] 216594006308 transaldolase; Provisional; Region: PRK03903 216594006309 catalytic residue [active] 216594006310 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 216594006311 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216594006312 TPP-binding site [chemical binding]; other site 216594006313 dimer interface [polypeptide binding]; other site 216594006314 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216594006315 PYR/PP interface [polypeptide binding]; other site 216594006316 dimer interface [polypeptide binding]; other site 216594006317 TPP binding site [chemical binding]; other site 216594006318 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216594006319 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 216594006320 UbiA prenyltransferase family; Region: UbiA; pfam01040 216594006321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594006322 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 216594006323 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 216594006324 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 216594006325 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 216594006326 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 216594006327 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 216594006328 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594006329 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594006330 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 216594006331 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 216594006332 NADP binding site [chemical binding]; other site 216594006333 dimer interface [polypeptide binding]; other site 216594006334 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 216594006335 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 216594006336 ABC-2 type transporter; Region: ABC2_membrane; cl17235 216594006337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216594006338 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216594006339 Walker A/P-loop; other site 216594006340 ATP binding site [chemical binding]; other site 216594006341 Q-loop/lid; other site 216594006342 ABC transporter signature motif; other site 216594006343 Walker B; other site 216594006344 D-loop; other site 216594006345 H-loop/switch region; other site 216594006346 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 216594006347 Predicted transcriptional regulator [Transcription]; Region: COG2345 216594006348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594006349 dimerization interface [polypeptide binding]; other site 216594006350 putative DNA binding site [nucleotide binding]; other site 216594006351 putative Zn2+ binding site [ion binding]; other site 216594006352 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 216594006353 FeS assembly protein SufB; Region: sufB; TIGR01980 216594006354 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 216594006355 FeS assembly protein SufD; Region: sufD; TIGR01981 216594006356 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 216594006357 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 216594006358 Walker A/P-loop; other site 216594006359 ATP binding site [chemical binding]; other site 216594006360 Q-loop/lid; other site 216594006361 ABC transporter signature motif; other site 216594006362 Walker B; other site 216594006363 D-loop; other site 216594006364 H-loop/switch region; other site 216594006365 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216594006366 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 216594006367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594006368 catalytic residue [active] 216594006369 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 216594006370 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 216594006371 trimerization site [polypeptide binding]; other site 216594006372 active site 216594006373 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 216594006374 PE family; Region: PE; pfam00934 216594006375 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 216594006376 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 216594006377 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594006378 active site 216594006379 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216594006380 PE family; Region: PE; pfam00934 216594006381 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 216594006382 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594006383 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 216594006384 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216594006385 catalytic residues [active] 216594006386 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216594006387 catalytic residues [active] 216594006388 enoyl-CoA hydratase; Provisional; Region: PRK05864 216594006389 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594006390 substrate binding site [chemical binding]; other site 216594006391 oxyanion hole (OAH) forming residues; other site 216594006392 trimer interface [polypeptide binding]; other site 216594006393 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216594006394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594006395 Walker A/P-loop; other site 216594006396 ATP binding site [chemical binding]; other site 216594006397 Q-loop/lid; other site 216594006398 ABC transporter signature motif; other site 216594006399 Walker B; other site 216594006400 D-loop; other site 216594006401 H-loop/switch region; other site 216594006402 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216594006403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594006404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594006405 aconitate hydratase; Validated; Region: PRK09277 216594006406 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 216594006407 substrate binding site [chemical binding]; other site 216594006408 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 216594006409 ligand binding site [chemical binding]; other site 216594006410 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 216594006411 substrate binding site [chemical binding]; other site 216594006412 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216594006413 NlpC/P60 family; Region: NLPC_P60; pfam00877 216594006414 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216594006415 NlpC/P60 family; Region: NLPC_P60; pfam00877 216594006416 MoxR-like ATPases [General function prediction only]; Region: COG0714 216594006417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594006418 Walker A motif; other site 216594006419 ATP binding site [chemical binding]; other site 216594006420 Walker B motif; other site 216594006421 arginine finger; other site 216594006422 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 216594006423 Protein of unknown function DUF58; Region: DUF58; pfam01882 216594006424 hypothetical protein; Provisional; Region: PRK13685 216594006425 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 216594006426 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 216594006427 metal ion-dependent adhesion site (MIDAS); other site 216594006428 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 216594006429 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 216594006430 NAD(P) binding site [chemical binding]; other site 216594006431 homotetramer interface [polypeptide binding]; other site 216594006432 homodimer interface [polypeptide binding]; other site 216594006433 active site 216594006434 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 216594006435 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 216594006436 NAD binding site [chemical binding]; other site 216594006437 homotetramer interface [polypeptide binding]; other site 216594006438 homodimer interface [polypeptide binding]; other site 216594006439 substrate binding site [chemical binding]; other site 216594006440 active site 216594006441 ferrochelatase; Reviewed; Region: hemH; PRK00035 216594006442 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 216594006443 C-terminal domain interface [polypeptide binding]; other site 216594006444 active site 216594006445 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 216594006446 active site 216594006447 N-terminal domain interface [polypeptide binding]; other site 216594006448 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 216594006449 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 216594006450 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 216594006451 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 216594006452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594006453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594006454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594006455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594006456 active site 216594006457 phosphorylation site [posttranslational modification] 216594006458 intermolecular recognition site; other site 216594006459 dimerization interface [polypeptide binding]; other site 216594006460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594006461 DNA binding site [nucleotide binding] 216594006462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216594006463 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 216594006464 dimer interface [polypeptide binding]; other site 216594006465 phosphorylation site [posttranslational modification] 216594006466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594006467 ATP binding site [chemical binding]; other site 216594006468 Mg2+ binding site [ion binding]; other site 216594006469 G-X-G motif; other site 216594006470 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 216594006471 Uncharacterized conserved protein [Function unknown]; Region: COG0398 216594006472 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 216594006473 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 216594006474 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 216594006475 heterodimer interface [polypeptide binding]; other site 216594006476 substrate interaction site [chemical binding]; other site 216594006477 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 216594006478 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 216594006479 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 216594006480 active site 216594006481 substrate binding site [chemical binding]; other site 216594006482 coenzyme B12 binding site [chemical binding]; other site 216594006483 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 216594006484 B12 binding site [chemical binding]; other site 216594006485 cobalt ligand [ion binding]; other site 216594006486 membrane ATPase/protein kinase; Provisional; Region: PRK09435 216594006487 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 216594006488 Walker A; other site 216594006489 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594006490 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594006491 Dodecin; Region: Dodecin; pfam07311 216594006492 MURD53; Overlaps CDS encoding N-term of a unique hypothetical membrane protein 216594006493 GtrA-like protein; Region: GtrA; pfam04138 216594006494 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 216594006495 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216594006496 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216594006497 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 216594006498 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216594006499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594006500 NAD(P) binding site [chemical binding]; other site 216594006501 active site 216594006502 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594006503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006504 S-adenosylmethionine binding site [chemical binding]; other site 216594006505 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 216594006506 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216594006507 active site 216594006508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594006509 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 216594006510 NAD(P) binding site [chemical binding]; other site 216594006511 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 216594006512 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216594006513 Ligand binding site; other site 216594006514 Putative Catalytic site; other site 216594006515 DXD motif; other site 216594006516 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 216594006517 MURD54; Function(s) of this large region unknown, harbours two PKS genes, each encoding single modules for production of a fully reduced methyl-branched ketide. This MURD also contains CDS that may play a role in amino acid metabolism and transport 216594006518 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594006519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006520 S-adenosylmethionine binding site [chemical binding]; other site 216594006521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594006522 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594006523 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 216594006524 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 216594006525 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216594006526 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216594006527 inhibitor-cofactor binding pocket; inhibition site 216594006528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594006529 catalytic residue [active] 216594006530 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 216594006531 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 216594006532 putative trimer interface [polypeptide binding]; other site 216594006533 putative CoA binding site [chemical binding]; other site 216594006534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006535 S-adenosylmethionine binding site [chemical binding]; other site 216594006536 Protein of unknown function, DUF393; Region: DUF393; pfam04134 216594006537 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 216594006538 WbqC-like protein family; Region: WbqC; pfam08889 216594006539 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216594006540 nucleotide binding site [chemical binding]; other site 216594006541 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 216594006542 active site 216594006543 NAD binding site [chemical binding]; other site 216594006544 metal binding site [ion binding]; metal-binding site 216594006545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594006546 classical (c) SDRs; Region: SDR_c; cd05233 216594006547 NAD(P) binding site [chemical binding]; other site 216594006548 active site 216594006549 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 216594006550 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 216594006551 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216594006552 PYR/PP interface [polypeptide binding]; other site 216594006553 dimer interface [polypeptide binding]; other site 216594006554 TPP binding site [chemical binding]; other site 216594006555 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216594006556 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 216594006557 TPP-binding site [chemical binding]; other site 216594006558 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 216594006559 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216594006560 Ligand binding site; other site 216594006561 Putative Catalytic site; other site 216594006562 DXD motif; other site 216594006563 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 216594006564 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 216594006565 substrate binding site; other site 216594006566 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 216594006567 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216594006568 inhibitor-cofactor binding pocket; inhibition site 216594006569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594006570 catalytic residue [active] 216594006571 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 216594006572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594006573 NAD(P) binding site [chemical binding]; other site 216594006574 active site 216594006575 Predicted membrane protein [Function unknown]; Region: COG2246 216594006576 GtrA-like protein; Region: GtrA; pfam04138 216594006577 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594006578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006579 S-adenosylmethionine binding site [chemical binding]; other site 216594006580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 216594006581 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594006582 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594006583 active site 216594006584 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 216594006585 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594006586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594006587 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594006588 Enoylreductase; Region: PKS_ER; smart00829 216594006589 NAD(P) binding site [chemical binding]; other site 216594006590 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 216594006591 KR domain; Region: KR; pfam08659 216594006592 putative NADP binding site [chemical binding]; other site 216594006593 active site 216594006594 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594006595 acyl-CoA synthetase; Validated; Region: PRK05850 216594006596 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594006597 acyl-activating enzyme (AAE) consensus motif; other site 216594006598 active site 216594006599 Transport protein; Region: actII; TIGR00833 216594006600 Condensation domain; Region: Condensation; pfam00668 216594006601 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594006602 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594006603 active site 216594006604 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594006605 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594006606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594006607 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594006608 Enoylreductase; Region: PKS_ER; smart00829 216594006609 NAD(P) binding site [chemical binding]; other site 216594006610 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 216594006611 KR domain; Region: KR; pfam08659 216594006612 putative NADP binding site [chemical binding]; other site 216594006613 active site 216594006614 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594006615 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216594006616 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216594006617 Nitronate monooxygenase; Region: NMO; pfam03060 216594006618 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216594006619 FMN binding site [chemical binding]; other site 216594006620 substrate binding site [chemical binding]; other site 216594006621 putative catalytic residue [active] 216594006622 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 216594006623 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216594006624 Probable Catalytic site; other site 216594006625 metal-binding site 216594006626 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594006627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006628 S-adenosylmethionine binding site [chemical binding]; other site 216594006629 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 216594006630 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216594006631 active site 216594006632 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 216594006633 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 216594006634 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 216594006635 homodimer interface [polypeptide binding]; other site 216594006636 active site 216594006637 TDP-binding site; other site 216594006638 acceptor substrate-binding pocket; other site 216594006639 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594006640 Condensation domain; Region: Condensation; pfam00668 216594006641 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 216594006642 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 216594006643 HIGH motif; other site 216594006644 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 216594006645 active site 216594006646 KMSKS motif; other site 216594006647 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 216594006648 tRNA binding surface [nucleotide binding]; other site 216594006649 anticodon binding site; other site 216594006650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006651 S-adenosylmethionine binding site [chemical binding]; other site 216594006652 DNA polymerase IV; Provisional; Region: PRK03348 216594006653 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 216594006654 active site 216594006655 DNA binding site [nucleotide binding] 216594006656 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 216594006657 active site 216594006658 homodimer interface [polypeptide binding]; other site 216594006659 homotetramer interface [polypeptide binding]; other site 216594006660 lipoprotein signal peptidase; Provisional; Region: PRK14764 216594006661 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 216594006662 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216594006663 active site 216594006664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594006665 S-adenosylmethionine binding site [chemical binding]; other site 216594006666 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 216594006667 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 216594006668 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 216594006669 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 216594006670 apolar tunnel; other site 216594006671 heme binding site [chemical binding]; other site 216594006672 dimerization interface [polypeptide binding]; other site 216594006673 short chain dehydrogenase; Provisional; Region: PRK05866 216594006674 classical (c) SDRs; Region: SDR_c; cd05233 216594006675 NAD(P) binding site [chemical binding]; other site 216594006676 active site 216594006677 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216594006678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594006679 NAD(P) binding site [chemical binding]; other site 216594006680 active site 216594006681 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216594006682 hydrophobic ligand binding site; other site 216594006683 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 216594006684 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 216594006685 active site 216594006686 PHP Thumb interface [polypeptide binding]; other site 216594006687 metal binding site [ion binding]; metal-binding site 216594006688 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 216594006689 generic binding surface II; other site 216594006690 generic binding surface I; other site 216594006691 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216594006692 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 216594006693 acyl-activating enzyme (AAE) consensus motif; other site 216594006694 putative AMP binding site [chemical binding]; other site 216594006695 putative active site [active] 216594006696 putative CoA binding site [chemical binding]; other site 216594006697 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 216594006698 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 216594006699 putative acyl-acceptor binding pocket; other site 216594006700 Domain of unknown function (DUF385); Region: DUF385; pfam04075 216594006701 threonine dehydratase; Validated; Region: PRK08639 216594006702 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 216594006703 tetramer interface [polypeptide binding]; other site 216594006704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594006705 catalytic residue [active] 216594006706 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 216594006707 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 216594006708 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 216594006709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594006710 DNA-binding site [nucleotide binding]; DNA binding site 216594006711 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594006712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594006713 homodimer interface [polypeptide binding]; other site 216594006714 catalytic residue [active] 216594006715 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 216594006716 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 216594006717 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 216594006718 catalytic site [active] 216594006719 active site 216594006720 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 216594006721 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 216594006722 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 216594006723 active site 216594006724 catalytic site [active] 216594006725 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 216594006726 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 216594006727 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 216594006728 active site 216594006729 catalytic site [active] 216594006730 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216594006731 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216594006732 NlpC/P60 family; Region: NLPC_P60; pfam00877 216594006733 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 216594006734 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594006735 inhibitor-cofactor binding pocket; inhibition site 216594006736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594006737 catalytic residue [active] 216594006738 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 216594006739 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 216594006740 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594006741 catalytic residue [active] 216594006742 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 216594006743 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 216594006744 biotin synthase; Validated; Region: PRK06256 216594006745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594006746 FeS/SAM binding site; other site 216594006747 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 216594006748 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 216594006749 Secretory lipase; Region: LIP; pfam03583 216594006750 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 216594006751 nudix motif; other site 216594006752 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 216594006753 quinolinate synthetase; Provisional; Region: PRK09375 216594006754 L-aspartate oxidase; Provisional; Region: PRK07804 216594006755 L-aspartate oxidase; Provisional; Region: PRK06175 216594006756 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216594006757 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 216594006758 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 216594006759 dimerization interface [polypeptide binding]; other site 216594006760 active site 216594006761 Domain of unknown function (DUF385); Region: DUF385; cl04387 216594006762 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 216594006763 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 216594006764 NAD binding site [chemical binding]; other site 216594006765 dimerization interface [polypeptide binding]; other site 216594006766 product binding site; other site 216594006767 substrate binding site [chemical binding]; other site 216594006768 zinc binding site [ion binding]; other site 216594006769 catalytic residues [active] 216594006770 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 216594006771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594006772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594006773 homodimer interface [polypeptide binding]; other site 216594006774 catalytic residue [active] 216594006775 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 216594006776 4-fold oligomerization interface [polypeptide binding]; other site 216594006777 putative active site pocket [active] 216594006778 metal binding residues [ion binding]; metal-binding site 216594006779 3-fold/trimer interface [polypeptide binding]; other site 216594006780 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 216594006781 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 216594006782 putative active site [active] 216594006783 oxyanion strand; other site 216594006784 catalytic triad [active] 216594006785 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 216594006786 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 216594006787 catalytic residues [active] 216594006788 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216594006789 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 216594006790 active site 216594006791 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 216594006792 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 216594006793 substrate binding site [chemical binding]; other site 216594006794 glutamase interaction surface [polypeptide binding]; other site 216594006795 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 216594006796 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 216594006797 active site 216594006798 Zn binding site [ion binding]; other site 216594006799 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 216594006800 proposed catalytic triad [active] 216594006801 active site nucleophile [active] 216594006802 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 216594006803 conserved cys residue [active] 216594006804 cyanophycin synthetase; Provisional; Region: PRK14016 216594006805 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216594006806 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216594006807 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216594006808 MURD55; Overlaps two genes whose products may play a role in amino acid transport in or out of the cell 216594006809 amino acid transporter; Region: 2A0306; TIGR00909 216594006810 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 216594006811 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594006812 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594006813 active site 216594006814 ATP binding site [chemical binding]; other site 216594006815 substrate binding site [chemical binding]; other site 216594006816 activation loop (A-loop); other site 216594006817 Repair protein; Region: Repair_PSII; pfam04536 216594006818 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 216594006819 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 216594006820 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 216594006821 catalytic triad [active] 216594006822 anthranilate synthase component I; Provisional; Region: PRK13571 216594006823 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216594006824 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216594006825 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 216594006826 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 216594006827 active site 216594006828 ribulose/triose binding site [chemical binding]; other site 216594006829 phosphate binding site [ion binding]; other site 216594006830 substrate (anthranilate) binding pocket [chemical binding]; other site 216594006831 product (indole) binding pocket [chemical binding]; other site 216594006832 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 216594006833 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 216594006834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594006835 catalytic residue [active] 216594006836 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 216594006837 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 216594006838 substrate binding site [chemical binding]; other site 216594006839 active site 216594006840 catalytic residues [active] 216594006841 heterodimer interface [polypeptide binding]; other site 216594006842 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 216594006843 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 216594006844 TM2 domain; Region: TM2; pfam05154 216594006845 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 216594006846 Cutinase; Region: Cutinase; pfam01083 216594006847 pyruvate kinase; Provisional; Region: PRK06247 216594006848 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 216594006849 domain interfaces; other site 216594006850 active site 216594006851 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 216594006852 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 216594006853 active site 216594006854 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 216594006855 catalytic triad [active] 216594006856 dimer interface [polypeptide binding]; other site 216594006857 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 216594006858 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 216594006859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594006860 Walker A/P-loop; other site 216594006861 ATP binding site [chemical binding]; other site 216594006862 Q-loop/lid; other site 216594006863 ABC transporter signature motif; other site 216594006864 Walker B; other site 216594006865 D-loop; other site 216594006866 H-loop/switch region; other site 216594006867 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 216594006868 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216594006869 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 216594006870 Walker A/P-loop; other site 216594006871 ATP binding site [chemical binding]; other site 216594006872 Q-loop/lid; other site 216594006873 ABC transporter signature motif; other site 216594006874 Walker B; other site 216594006875 D-loop; other site 216594006876 H-loop/switch region; other site 216594006877 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 216594006878 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 216594006879 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 216594006880 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 216594006881 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 216594006882 cyclase homology domain; Region: CHD; cd07302 216594006883 nucleotidyl binding site; other site 216594006884 metal binding site [ion binding]; metal-binding site 216594006885 dimer interface [polypeptide binding]; other site 216594006886 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 216594006887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594006888 active site 216594006889 phosphorylation site [posttranslational modification] 216594006890 intermolecular recognition site; other site 216594006891 dimerization interface [polypeptide binding]; other site 216594006892 ANTAR domain; Region: ANTAR; pfam03861 216594006893 lipid-transfer protein; Provisional; Region: PRK06059 216594006894 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594006895 active site 216594006896 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 216594006897 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 216594006898 DUF35 OB-fold domain; Region: DUF35; pfam01796 216594006899 DNA polymerase I; Provisional; Region: PRK05755 216594006900 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 216594006901 active site 216594006902 metal binding site 1 [ion binding]; metal-binding site 216594006903 putative 5' ssDNA interaction site; other site 216594006904 metal binding site 3; metal-binding site 216594006905 metal binding site 2 [ion binding]; metal-binding site 216594006906 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 216594006907 putative DNA binding site [nucleotide binding]; other site 216594006908 putative metal binding site [ion binding]; other site 216594006909 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 216594006910 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 216594006911 active site 216594006912 DNA binding site [nucleotide binding] 216594006913 catalytic site [active] 216594006914 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 216594006915 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 216594006916 RNA binding site [nucleotide binding]; other site 216594006917 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 216594006918 RNA binding site [nucleotide binding]; other site 216594006919 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216594006920 RNA binding site [nucleotide binding]; other site 216594006921 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 216594006922 RNA binding site [nucleotide binding]; other site 216594006923 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 216594006924 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 216594006925 CoA-binding site [chemical binding]; other site 216594006926 ATP-binding [chemical binding]; other site 216594006927 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 216594006928 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 216594006929 Protein of unknown function (DUF402); Region: DUF402; cl00979 216594006930 excinuclease ABC subunit B; Provisional; Region: PRK05298 216594006931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594006932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594006933 nucleotide binding region [chemical binding]; other site 216594006934 ATP-binding site [chemical binding]; other site 216594006935 Ultra-violet resistance protein B; Region: UvrB; pfam12344 216594006936 UvrB/uvrC motif; Region: UVR; pfam02151 216594006937 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216594006938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594006939 putative substrate translocation pore; other site 216594006940 Predicted membrane protein [Function unknown]; Region: COG5305 216594006941 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594006942 Ligand Binding Site [chemical binding]; other site 216594006943 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 216594006944 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216594006945 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 216594006946 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216594006947 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216594006948 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 216594006949 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594006950 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594006951 active site 216594006952 ATP binding site [chemical binding]; other site 216594006953 substrate binding site [chemical binding]; other site 216594006954 activation loop (A-loop); other site 216594006955 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594006956 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 216594006957 Predicted esterase [General function prediction only]; Region: COG0627 216594006958 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 216594006959 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 216594006960 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 216594006961 dimer interface [polypeptide binding]; other site 216594006962 putative anticodon binding site; other site 216594006963 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216594006964 motif 1; other site 216594006965 dimer interface [polypeptide binding]; other site 216594006966 active site 216594006967 motif 2; other site 216594006968 motif 3; other site 216594006969 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 216594006970 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 216594006971 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 216594006972 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 216594006973 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 216594006974 23S rRNA binding site [nucleotide binding]; other site 216594006975 L21 binding site [polypeptide binding]; other site 216594006976 L13 binding site [polypeptide binding]; other site 216594006977 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216594006978 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 216594006979 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216594006980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 216594006981 PE family; Region: PE; pfam00934 216594006982 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594006983 cyclase homology domain; Region: CHD; cd07302 216594006984 nucleotidyl binding site; other site 216594006985 metal binding site [ion binding]; metal-binding site 216594006986 dimer interface [polypeptide binding]; other site 216594006987 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 216594006988 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 216594006989 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 216594006990 dimer interface [polypeptide binding]; other site 216594006991 motif 1; other site 216594006992 active site 216594006993 motif 2; other site 216594006994 motif 3; other site 216594006995 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 216594006996 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 216594006997 putative tRNA-binding site [nucleotide binding]; other site 216594006998 B3/4 domain; Region: B3_4; pfam03483 216594006999 tRNA synthetase B5 domain; Region: B5; pfam03484 216594007000 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 216594007001 dimer interface [polypeptide binding]; other site 216594007002 motif 1; other site 216594007003 motif 3; other site 216594007004 motif 2; other site 216594007005 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 216594007006 PE family; Region: PE; pfam00934 216594007007 PE family; Region: PE; pfam00934 216594007008 PE family; Region: PE; pfam00934 216594007009 PE family; Region: PE; pfam00934 216594007010 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 216594007011 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216594007012 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 216594007013 heterotetramer interface [polypeptide binding]; other site 216594007014 active site pocket [active] 216594007015 cleavage site 216594007016 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 216594007017 feedback inhibition sensing region; other site 216594007018 homohexameric interface [polypeptide binding]; other site 216594007019 nucleotide binding site [chemical binding]; other site 216594007020 N-acetyl-L-glutamate binding site [chemical binding]; other site 216594007021 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 216594007022 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594007023 inhibitor-cofactor binding pocket; inhibition site 216594007024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594007025 catalytic residue [active] 216594007026 ornithine carbamoyltransferase; Provisional; Region: PRK00779 216594007027 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216594007028 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216594007029 arginine repressor; Provisional; Region: PRK03341 216594007030 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 216594007031 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 216594007032 argininosuccinate synthase; Provisional; Region: PRK13820 216594007033 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 216594007034 ANP binding site [chemical binding]; other site 216594007035 Substrate Binding Site II [chemical binding]; other site 216594007036 Substrate Binding Site I [chemical binding]; other site 216594007037 argininosuccinate lyase; Provisional; Region: PRK00855 216594007038 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 216594007039 active sites [active] 216594007040 tetramer interface [polypeptide binding]; other site 216594007041 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 216594007042 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 216594007043 malonyl-CoA binding site [chemical binding]; other site 216594007044 dimer interface [polypeptide binding]; other site 216594007045 active site 216594007046 product binding site; other site 216594007047 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594007048 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594007049 active site 216594007050 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594007051 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594007052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594007053 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594007054 Enoylreductase; Region: PKS_ER; smart00829 216594007055 NAD(P) binding site [chemical binding]; other site 216594007056 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594007057 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594007058 putative NADP binding site [chemical binding]; other site 216594007059 active site 216594007060 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594007061 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594007062 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594007063 active site 216594007064 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594007065 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594007066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594007067 Enoylreductase; Region: PKS_ER; smart00829 216594007068 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594007069 NAD(P) binding site [chemical binding]; other site 216594007070 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594007071 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594007072 putative NADP binding site [chemical binding]; other site 216594007073 active site 216594007074 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594007075 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594007076 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594007077 active site 216594007078 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594007079 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594007080 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 216594007081 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 216594007082 malonyl-CoA binding site [chemical binding]; other site 216594007083 dimer interface [polypeptide binding]; other site 216594007084 active site 216594007085 product binding site; other site 216594007086 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594007087 Cytochrome P450; Region: p450; cl12078 216594007088 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216594007089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216594007090 ABC transporter; Region: ABC_tran_2; pfam12848 216594007091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216594007092 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216594007093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594007094 acyl-CoA synthetase; Validated; Region: PRK07868 216594007095 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594007096 acyl-activating enzyme (AAE) consensus motif; other site 216594007097 AMP binding site [chemical binding]; other site 216594007098 active site 216594007099 CoA binding site [chemical binding]; other site 216594007100 Uncharacterized conserved protein [Function unknown]; Region: COG2835 216594007101 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 216594007102 putative dimer interface [polypeptide binding]; other site 216594007103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594007104 PE family; Region: PE; pfam00934 216594007105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594007107 ABC-2 type transporter; Region: ABC2_membrane; cl17235 216594007108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594007110 ABC-2 type transporter; Region: ABC2_membrane; cl17235 216594007111 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216594007112 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 216594007113 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216594007114 Walker A/P-loop; other site 216594007115 ATP binding site [chemical binding]; other site 216594007116 Q-loop/lid; other site 216594007117 ABC transporter signature motif; other site 216594007118 Walker B; other site 216594007119 D-loop; other site 216594007120 H-loop/switch region; other site 216594007121 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 216594007122 active site 216594007123 DNA binding site [nucleotide binding] 216594007124 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 216594007125 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 216594007126 active site 216594007127 HIGH motif; other site 216594007128 dimer interface [polypeptide binding]; other site 216594007129 KMSKS motif; other site 216594007130 S4 RNA-binding domain; Region: S4; smart00363 216594007131 RNA binding surface [nucleotide binding]; other site 216594007132 MURD56; Putative insertion sequence 216594007133 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 216594007134 Winged helix-turn helix; Region: HTH_29; pfam13551 216594007135 Integrase core domain; Region: rve; pfam00665 216594007136 Integrase core domain; Region: rve_3; pfam13683 216594007137 PE family; Region: PE; pfam00934 216594007138 Double zinc ribbon; Region: DZR; pfam12773 216594007139 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 216594007140 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 216594007141 PE family; Region: PE; pfam00934 216594007142 Uncharacterized conserved protein [Function unknown]; Region: COG3482 216594007143 uncharacterized domain; Region: TIGR00702 216594007144 YcaO-like family; Region: YcaO; pfam02624 216594007145 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594007146 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 216594007147 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 216594007148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594007149 active site 216594007150 motif I; other site 216594007151 motif II; other site 216594007152 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 216594007153 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 216594007154 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216594007155 RNA binding surface [nucleotide binding]; other site 216594007156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594007157 S-adenosylmethionine binding site [chemical binding]; other site 216594007158 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 216594007159 ATP-NAD kinase; Region: NAD_kinase; pfam01513 216594007160 DNA repair protein RecN; Region: recN; TIGR00634 216594007161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594007162 Walker A/P-loop; other site 216594007163 ATP binding site [chemical binding]; other site 216594007164 Q-loop/lid; other site 216594007165 ABC transporter signature motif; other site 216594007166 Walker B; other site 216594007167 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 216594007168 ABC transporter signature motif; other site 216594007169 Walker B; other site 216594007170 D-loop; other site 216594007171 H-loop/switch region; other site 216594007172 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 216594007173 Thiamine pyrophosphokinase; Region: TPK; cl08415 216594007174 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 216594007175 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 216594007176 CTP synthetase; Validated; Region: pyrG; PRK05380 216594007177 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 216594007178 Catalytic site [active] 216594007179 active site 216594007180 UTP binding site [chemical binding]; other site 216594007181 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 216594007182 active site 216594007183 putative oxyanion hole; other site 216594007184 catalytic triad [active] 216594007185 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 216594007186 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 216594007187 dimer interface [polypeptide binding]; other site 216594007188 ADP-ribose binding site [chemical binding]; other site 216594007189 active site 216594007190 nudix motif; other site 216594007191 metal binding site [ion binding]; metal-binding site 216594007192 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 216594007193 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594007194 active site 216594007195 DNA binding site [nucleotide binding] 216594007196 Int/Topo IB signature motif; other site 216594007197 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 216594007198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594007199 S-adenosylmethionine binding site [chemical binding]; other site 216594007200 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 216594007201 UbiA prenyltransferase family; Region: UbiA; pfam01040 216594007202 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 216594007203 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216594007204 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 216594007205 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 216594007206 TatD related DNase; Region: TatD_DNase; pfam01026 216594007207 active site 216594007208 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216594007209 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 216594007210 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594007211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594007212 putative substrate translocation pore; other site 216594007213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594007214 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007215 PPE family; Region: PPE; pfam00823 216594007216 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594007217 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007218 PPE family; Region: PPE; pfam00823 216594007219 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594007220 Condensation domain; Region: Condensation; pfam00668 216594007221 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594007222 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594007223 acyl-activating enzyme (AAE) consensus motif; other site 216594007224 AMP binding site [chemical binding]; other site 216594007225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594007226 Condensation domain; Region: Condensation; pfam00668 216594007227 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216594007228 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 216594007229 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594007230 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594007231 acyl-activating enzyme (AAE) consensus motif; other site 216594007232 AMP binding site [chemical binding]; other site 216594007233 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594007234 MURD57; This region lies within a two-module NRP - peptide product unknown 216594007235 MbtH-like protein; Region: MbtH; pfam03621 216594007236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594007237 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594007238 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594007239 active site 216594007240 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 216594007241 heme binding pocket [chemical binding]; other site 216594007242 heme ligand [chemical binding]; other site 216594007243 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216594007244 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216594007245 P loop; other site 216594007246 Nucleotide binding site [chemical binding]; other site 216594007247 DTAP/Switch II; other site 216594007248 Switch I; other site 216594007249 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216594007250 Magnesium ion binding site [ion binding]; other site 216594007251 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 216594007252 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 216594007253 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 216594007254 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216594007255 RNA binding surface [nucleotide binding]; other site 216594007256 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 216594007257 active site 216594007258 cytidylate kinase; Provisional; Region: cmk; PRK00023 216594007259 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 216594007260 CMP-binding site; other site 216594007261 The sites determining sugar specificity; other site 216594007262 GTP-binding protein Der; Reviewed; Region: PRK03003 216594007263 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 216594007264 G1 box; other site 216594007265 GTP/Mg2+ binding site [chemical binding]; other site 216594007266 Switch I region; other site 216594007267 G2 box; other site 216594007268 Switch II region; other site 216594007269 G3 box; other site 216594007270 G4 box; other site 216594007271 G5 box; other site 216594007272 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 216594007273 G1 box; other site 216594007274 GTP/Mg2+ binding site [chemical binding]; other site 216594007275 Switch I region; other site 216594007276 G2 box; other site 216594007277 G3 box; other site 216594007278 Switch II region; other site 216594007279 G4 box; other site 216594007280 G5 box; other site 216594007281 bacteriophage phiMmar07; MURD58; Putative prophage, insertion at proline tRNA gene. Harbours a CDS encoding PPE family protein 216594007282 Transposase; Region: HTH_Tnp_1; cl17663 216594007283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216594007284 putative transposase OrfB; Reviewed; Region: PHA02517 216594007285 HTH-like domain; Region: HTH_21; pfam13276 216594007286 Integrase core domain; Region: rve; pfam00665 216594007287 Integrase core domain; Region: rve_3; pfam13683 216594007288 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 216594007289 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007290 PPE family; Region: PPE; pfam00823 216594007291 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594007292 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 216594007293 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594007294 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594007295 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 216594007296 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 216594007297 putative homodimer interface [polypeptide binding]; other site 216594007298 putative homotetramer interface [polypeptide binding]; other site 216594007299 allosteric switch controlling residues; other site 216594007300 putative metal binding site [ion binding]; other site 216594007301 putative homodimer-homodimer interface [polypeptide binding]; other site 216594007302 Uncharacterized conserved protein [Function unknown]; Region: COG3391 216594007303 NHL repeat; Region: NHL; pfam01436 216594007304 NHL repeat; Region: NHL; pfam01436 216594007305 NHL repeat; Region: NHL; pfam01436 216594007306 NHL repeat; Region: NHL; pfam01436 216594007307 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 216594007308 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594007309 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 216594007310 active site clefts [active] 216594007311 zinc binding site [ion binding]; other site 216594007312 dimer interface [polypeptide binding]; other site 216594007313 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 216594007314 Transposase; Region: HTH_Tnp_1; cl17663 216594007315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216594007316 putative transposase OrfB; Reviewed; Region: PHA02517 216594007317 HTH-like domain; Region: HTH_21; pfam13276 216594007318 Integrase core domain; Region: rve; pfam00665 216594007319 Integrase core domain; Region: rve_3; pfam13683 216594007320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594007321 dimerization interface [polypeptide binding]; other site 216594007322 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594007323 cyclase homology domain; Region: CHD; cd07302 216594007324 nucleotidyl binding site; other site 216594007325 metal binding site [ion binding]; metal-binding site 216594007326 dimer interface [polypeptide binding]; other site 216594007327 PE family; Region: PE; pfam00934 216594007328 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 216594007329 substrate binding pocket [chemical binding]; other site 216594007330 catalytic residues [active] 216594007331 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 216594007332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594007333 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 216594007334 active site 216594007335 catalytic residues [active] 216594007336 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216594007337 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216594007338 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594007339 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 216594007340 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216594007341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594007342 DNA-binding site [nucleotide binding]; DNA binding site 216594007343 UTRA domain; Region: UTRA; pfam07702 216594007344 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216594007345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 216594007346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 216594007347 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216594007348 homotrimer interaction site [polypeptide binding]; other site 216594007349 putative active site [active] 216594007350 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 216594007351 substrate binding pocket [chemical binding]; other site 216594007352 substrate-Mg2+ binding site; other site 216594007353 aspartate-rich region 1; other site 216594007354 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594007355 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594007356 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 216594007357 homodimer interface [polypeptide binding]; other site 216594007358 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 216594007359 active site pocket [active] 216594007360 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 216594007361 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 216594007362 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 216594007363 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 216594007364 NAD(P) binding site [chemical binding]; other site 216594007365 catalytic residues [active] 216594007366 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 216594007367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594007368 putative substrate translocation pore; other site 216594007369 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 216594007370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594007371 PE family; Region: PE; pfam00934 216594007372 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594007373 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594007374 active site 216594007375 ATP binding site [chemical binding]; other site 216594007376 substrate binding site [chemical binding]; other site 216594007377 activation loop (A-loop); other site 216594007378 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216594007379 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 216594007380 AAA ATPase domain; Region: AAA_16; pfam13191 216594007381 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 216594007382 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 216594007383 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 216594007384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594007385 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 216594007386 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216594007387 amino acid transporter; Region: 2A0306; TIGR00909 216594007388 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594007389 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594007390 active site 216594007391 ATP binding site [chemical binding]; other site 216594007392 substrate binding site [chemical binding]; other site 216594007393 activation loop (A-loop); other site 216594007394 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 216594007395 Acyltransferase family; Region: Acyl_transf_3; pfam01757 216594007396 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 216594007397 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216594007398 TrkA-C domain; Region: TrkA_C; pfam02080 216594007399 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 216594007400 TrkA-N domain; Region: TrkA_N; pfam02254 216594007401 TrkA-C domain; Region: TrkA_C; pfam02080 216594007402 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 216594007403 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 216594007404 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 216594007405 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216594007406 RNA binding site [nucleotide binding]; other site 216594007407 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 216594007408 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 216594007409 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 216594007410 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 216594007411 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 216594007412 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 216594007413 catalytic residue [active] 216594007414 putative FPP diphosphate binding site; other site 216594007415 putative FPP binding hydrophobic cleft; other site 216594007416 dimer interface [polypeptide binding]; other site 216594007417 putative IPP diphosphate binding site; other site 216594007418 NYN domain; Region: NYN; pfam01936 216594007419 putative metal binding site [ion binding]; other site 216594007420 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 216594007421 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007422 PPE family; Region: PPE; pfam00823 216594007423 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 216594007424 classical (c) SDRs; Region: SDR_c; cd05233 216594007425 NAD(P) binding site [chemical binding]; other site 216594007426 active site 216594007427 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 216594007428 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 216594007429 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 216594007430 PE family; Region: PE; pfam00934 216594007431 MURD157; Overlaps the C-term of PE-PGRS family gene 216594007432 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 216594007433 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594007434 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 216594007435 acyl-activating enzyme (AAE) consensus motif; other site 216594007436 acyl-activating enzyme (AAE) consensus motif; other site 216594007437 putative AMP binding site [chemical binding]; other site 216594007438 putative active site [active] 216594007439 putative CoA binding site [chemical binding]; other site 216594007440 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594007441 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594007442 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594007443 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594007444 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 216594007445 classical (c) SDRs; Region: SDR_c; cd05233 216594007446 short chain dehydrogenase; Provisional; Region: PRK07832 216594007447 NAD(P) binding site [chemical binding]; other site 216594007448 active site 216594007449 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594007450 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594007451 Cupin domain; Region: Cupin_2; cl17218 216594007452 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 216594007453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594007454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216594007455 putative substrate translocation pore; other site 216594007456 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 216594007457 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216594007458 molybdopterin cofactor binding site; other site 216594007459 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 216594007460 putative molybdopterin cofactor binding site; other site 216594007461 MURD59; Overlaps four CDS encoding the STPK, PknF and MaoX - a copper methylamine oxidase precursor and other hypothetical membrane proteins 216594007462 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594007463 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594007464 active site 216594007465 ATP binding site [chemical binding]; other site 216594007466 substrate binding site [chemical binding]; other site 216594007467 activation loop (A-loop); other site 216594007468 tyramine oxidase; Provisional; Region: tynA; PRK11504 216594007469 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 216594007470 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 216594007471 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 216594007472 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216594007473 Cation efflux family; Region: Cation_efflux; cl00316 216594007474 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 216594007475 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 216594007476 tetrameric interface [polypeptide binding]; other site 216594007477 NAD binding site [chemical binding]; other site 216594007478 catalytic residues [active] 216594007479 substrate binding site [chemical binding]; other site 216594007480 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216594007481 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 216594007482 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 216594007483 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594007484 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594007485 phosphopeptide binding site; other site 216594007486 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594007487 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594007488 phosphopeptide binding site; other site 216594007489 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 216594007490 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 216594007491 Walker A/P-loop; other site 216594007492 ATP binding site [chemical binding]; other site 216594007493 Q-loop/lid; other site 216594007494 ABC transporter signature motif; other site 216594007495 Walker B; other site 216594007496 D-loop; other site 216594007497 H-loop/switch region; other site 216594007498 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216594007499 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216594007500 Peptidase family M48; Region: Peptidase_M48; pfam01435 216594007501 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216594007502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594007503 Coenzyme A binding pocket [chemical binding]; other site 216594007504 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594007505 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 216594007506 acyl-activating enzyme (AAE) consensus motif; other site 216594007507 putative AMP binding site [chemical binding]; other site 216594007508 putative active site [active] 216594007509 putative CoA binding site [chemical binding]; other site 216594007510 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 216594007511 intersubunit interface [polypeptide binding]; other site 216594007512 active site 216594007513 Zn2+ binding site [ion binding]; other site 216594007514 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594007515 MURD60; Putative insertion sequence 216594007516 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 216594007517 Winged helix-turn helix; Region: HTH_29; pfam13551 216594007518 Integrase core domain; Region: rve; pfam00665 216594007519 Integrase core domain; Region: rve_3; pfam13683 216594007520 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 216594007521 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594007522 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594007523 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594007524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594007525 short chain dehydrogenase; Provisional; Region: PRK08267 216594007526 classical (c) SDRs; Region: SDR_c; cd05233 216594007527 NAD(P) binding site [chemical binding]; other site 216594007528 active site 216594007529 acyl-CoA synthetase; Provisional; Region: PRK13388 216594007530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594007531 acyl-activating enzyme (AAE) consensus motif; other site 216594007532 AMP binding site [chemical binding]; other site 216594007533 active site 216594007534 CoA binding site [chemical binding]; other site 216594007535 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 216594007536 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594007537 hypothetical protein; Provisional; Region: PRK06185 216594007538 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594007539 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594007540 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216594007541 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216594007542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594007543 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 216594007544 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 216594007545 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594007546 Cytochrome P450; Region: p450; cl12078 216594007547 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 216594007548 classical (c) SDRs; Region: SDR_c; cd05233 216594007549 NAD(P) binding site [chemical binding]; other site 216594007550 active site 216594007551 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594007552 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594007553 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 216594007554 Uncharacterized conserved protein [Function unknown]; Region: COG0393 216594007555 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 216594007556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594007559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594007560 S-adenosylmethionine binding site [chemical binding]; other site 216594007561 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216594007562 catalytic residues [active] 216594007563 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 216594007564 putative homotetramer interface [polypeptide binding]; other site 216594007565 putative homodimer interface [polypeptide binding]; other site 216594007566 putative allosteric switch controlling residues; other site 216594007567 putative metal binding site [ion binding]; other site 216594007568 putative homodimer-homodimer interface [polypeptide binding]; other site 216594007569 Domain of unknown function DUF302; Region: DUF302; pfam03625 216594007570 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 216594007571 PE family; Region: PE; pfam00934 216594007572 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 216594007573 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 216594007574 dimer interface [polypeptide binding]; other site 216594007575 active site 216594007576 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216594007577 substrate binding site [chemical binding]; other site 216594007578 catalytic residue [active] 216594007579 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 216594007580 Peptidase family M28; Region: Peptidase_M28; pfam04389 216594007581 metal binding site [ion binding]; metal-binding site 216594007582 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 216594007583 FAD binding domain; Region: FAD_binding_4; pfam01565 216594007584 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 216594007585 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594007586 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594007587 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007588 PPE family; Region: PPE; pfam00823 216594007589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007590 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594007591 Cytochrome P450; Region: p450; cl12078 216594007592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594007594 PE family; Region: PE; pfam00934 216594007595 MURD61; Overlaps a PE-PGRS family gene 216594007596 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216594007597 Isochorismatase family; Region: Isochorismatase; pfam00857 216594007598 catalytic triad [active] 216594007599 conserved cis-peptide bond; other site 216594007600 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 216594007601 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216594007602 hydrophobic ligand binding site; other site 216594007603 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 216594007604 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 216594007605 ESX-5 216594007606 Protein of unknown function (DUF690); Region: DUF690; pfam05108 216594007607 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 216594007608 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594007609 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 216594007610 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594007611 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594007612 Cytochrome P450; Region: p450; cl12078 216594007613 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 216594007614 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007615 PPE family; Region: PPE; pfam00823 216594007616 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594007617 PE family; Region: PE; pfam00934 216594007618 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007619 PPE family; Region: PPE; pfam00823 216594007620 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594007621 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594007622 PE family; Region: PE; pfam00934 216594007623 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 216594007624 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 216594007625 EspG family; Region: ESX-1_EspG; pfam14011 216594007626 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 216594007627 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 216594007628 catalytic residues [active] 216594007629 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 216594007630 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 216594007631 active site 216594007632 catalytic residues [active] 216594007633 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 216594007634 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 216594007635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594007636 Walker A motif; other site 216594007637 ATP binding site [chemical binding]; other site 216594007638 Walker B motif; other site 216594007639 arginine finger; other site 216594007640 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007641 PPE family; Region: PPE; pfam00823 216594007642 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007643 PPE family; Region: PPE; pfam00823 216594007644 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594007645 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007646 PPE family; Region: PPE; pfam00823 216594007647 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007648 PPE family; Region: PPE; pfam00823 216594007649 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594007650 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007651 PPE family; Region: PPE; pfam00823 216594007652 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594007653 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 216594007654 MgtC family; Region: MgtC; pfam02308 216594007655 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 216594007656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594007657 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594007658 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 216594007659 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 216594007660 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216594007661 active site 216594007662 metal binding site [ion binding]; metal-binding site 216594007663 hypothetical protein; Validated; Region: PRK07121 216594007664 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 216594007665 PE family; Region: PE; pfam00934 216594007666 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 216594007667 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 216594007668 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 216594007669 hypothetical protein; Provisional; Region: PRK05858 216594007670 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216594007671 PYR/PP interface [polypeptide binding]; other site 216594007672 dimer interface [polypeptide binding]; other site 216594007673 TPP binding site [chemical binding]; other site 216594007674 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216594007675 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 216594007676 TPP-binding site; other site 216594007677 dimer interface [polypeptide binding]; other site 216594007678 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 216594007679 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 216594007680 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 216594007681 nucleotide binding region [chemical binding]; other site 216594007682 ATP-binding site [chemical binding]; other site 216594007683 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 216594007684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 216594007685 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 216594007686 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 216594007687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 216594007688 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 216594007689 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 216594007690 lipoyl attachment site [posttranslational modification]; other site 216594007691 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594007692 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594007693 phosphopeptide binding site; other site 216594007694 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 216594007695 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216594007696 DNA binding residues [nucleotide binding] 216594007697 Bifunctional nuclease; Region: DNase-RNase; pfam02577 216594007698 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 216594007699 DNA binding residues [nucleotide binding] 216594007700 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216594007701 putative dimer interface [polypeptide binding]; other site 216594007702 glycine dehydrogenase; Provisional; Region: PRK05367 216594007703 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216594007704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594007705 tetramer interface [polypeptide binding]; other site 216594007706 catalytic residue [active] 216594007707 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216594007708 tetramer interface [polypeptide binding]; other site 216594007709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594007710 catalytic residue [active] 216594007711 PE family; Region: PE; pfam00934 216594007712 haloalkane dehalogenase; Provisional; Region: PRK03204 216594007713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594007714 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216594007715 metal ion-dependent adhesion site (MIDAS); other site 216594007716 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 216594007717 active site 216594007718 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216594007719 Domain of unknown function DUF21; Region: DUF21; pfam01595 216594007720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216594007721 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216594007722 Domain of unknown function DUF21; Region: DUF21; pfam01595 216594007723 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216594007724 Transporter associated domain; Region: CorC_HlyC; smart01091 216594007725 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 216594007726 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216594007727 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 216594007728 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 216594007729 active site 216594007730 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216594007731 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 216594007732 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 216594007733 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 216594007734 Predicted transcriptional regulator [Transcription]; Region: COG3682 216594007735 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594007736 CoenzymeA binding site [chemical binding]; other site 216594007737 subunit interaction site [polypeptide binding]; other site 216594007738 PHB binding site; other site 216594007739 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 216594007740 alpha-gamma subunit interface [polypeptide binding]; other site 216594007741 beta-gamma subunit interface [polypeptide binding]; other site 216594007742 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 216594007743 gamma-beta subunit interface [polypeptide binding]; other site 216594007744 alpha-beta subunit interface [polypeptide binding]; other site 216594007745 urease subunit alpha; Reviewed; Region: ureC; PRK13206 216594007746 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 216594007747 subunit interactions [polypeptide binding]; other site 216594007748 active site 216594007749 flap region; other site 216594007750 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 216594007751 UreF; Region: UreF; pfam01730 216594007752 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216594007753 UreD urease accessory protein; Region: UreD; cl00530 216594007754 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 216594007755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594007756 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 216594007757 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594007758 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594007759 classical (c) SDRs; Region: SDR_c; cd05233 216594007760 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 216594007761 NAD(P) binding site [chemical binding]; other site 216594007762 active site 216594007763 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 216594007764 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216594007765 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216594007766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594007767 dimer interface [polypeptide binding]; other site 216594007768 conserved gate region; other site 216594007769 putative PBP binding loops; other site 216594007770 ABC-ATPase subunit interface; other site 216594007771 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594007772 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 216594007773 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 216594007774 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 216594007775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594007776 Walker A/P-loop; other site 216594007777 ATP binding site [chemical binding]; other site 216594007778 Q-loop/lid; other site 216594007779 ABC transporter signature motif; other site 216594007780 Walker B; other site 216594007781 D-loop; other site 216594007782 H-loop/switch region; other site 216594007783 TOBE domain; Region: TOBE; pfam03459 216594007784 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 216594007785 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 216594007786 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594007787 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 216594007788 NAD(P) binding site [chemical binding]; other site 216594007789 CAAX protease self-immunity; Region: Abi; pfam02517 216594007790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 216594007791 MOSC domain; Region: MOSC; pfam03473 216594007792 putative phosphoketolase; Provisional; Region: PRK05261 216594007793 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 216594007794 TPP-binding site; other site 216594007795 XFP C-terminal domain; Region: XFP_C; pfam09363 216594007796 short chain dehydrogenase; Provisional; Region: PRK07825 216594007797 classical (c) SDRs; Region: SDR_c; cd05233 216594007798 NAD(P) binding site [chemical binding]; other site 216594007799 active site 216594007800 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216594007801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594007802 Coenzyme A binding pocket [chemical binding]; other site 216594007803 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594007804 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594007805 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594007806 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594007807 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 216594007808 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594007809 active site 216594007810 hypothetical protein; Provisional; Region: PRK12320 216594007811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594007812 NAD(P) binding site [chemical binding]; other site 216594007813 active site 216594007814 Protein of unknown function, DUF606; Region: DUF606; pfam04657 216594007815 Domain of unknown function (DUF385); Region: DUF385; pfam04075 216594007816 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 216594007817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594007818 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216594007819 Walker A motif; other site 216594007820 ATP binding site [chemical binding]; other site 216594007821 Walker B motif; other site 216594007822 arginine finger; other site 216594007823 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216594007824 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 216594007825 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 216594007826 active site 216594007827 substrate binding site [chemical binding]; other site 216594007828 FMN binding site [chemical binding]; other site 216594007829 putative catalytic residues [active] 216594007830 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 216594007831 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216594007832 active site 216594007833 catalytic site [active] 216594007834 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 216594007835 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 216594007836 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 216594007837 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 216594007838 dimer interface [polypeptide binding]; other site 216594007839 decamer (pentamer of dimers) interface [polypeptide binding]; other site 216594007840 catalytic triad [active] 216594007841 peroxidatic and resolving cysteines [active] 216594007842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216594007843 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 216594007844 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 216594007845 dimerization interface [polypeptide binding]; other site 216594007846 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 216594007847 enoyl-CoA hydratase; Provisional; Region: PRK06688 216594007848 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594007849 substrate binding site [chemical binding]; other site 216594007850 oxyanion hole (OAH) forming residues; other site 216594007851 trimer interface [polypeptide binding]; other site 216594007852 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 216594007853 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 216594007854 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 216594007855 heme binding site [chemical binding]; other site 216594007856 ferroxidase pore; other site 216594007857 ferroxidase diiron center [ion binding]; other site 216594007858 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216594007859 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216594007860 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216594007861 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594007862 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 216594007863 Amidase; Region: Amidase; cl11426 216594007864 Condensation domain; Region: Condensation; pfam00668 216594007865 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594007866 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594007867 acyl-activating enzyme (AAE) consensus motif; other site 216594007868 AMP binding site [chemical binding]; other site 216594007869 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594007870 Condensation domain; Region: Condensation; pfam00668 216594007871 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594007872 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594007873 MURD62; Overlaps the C-term of a NRP 216594007874 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216594007875 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594007876 Cytochrome P450; Region: p450; cl12078 216594007877 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 216594007878 short chain dehydrogenase; Provisional; Region: PRK08267 216594007879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594007880 NAD(P) binding site [chemical binding]; other site 216594007881 active site 216594007882 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216594007883 hydrophobic ligand binding site; other site 216594007884 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 216594007885 chorismate mutase; Provisional; Region: PRK09269 216594007886 chorismate mutase, putative; Region: CM_mono2; TIGR01806 216594007887 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594007888 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 216594007889 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594007890 Putative esterase; Region: Esterase; pfam00756 216594007891 YceI-like domain; Region: YceI; smart00867 216594007892 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216594007893 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 216594007894 putative NAD(P) binding site [chemical binding]; other site 216594007895 putative substrate binding site [chemical binding]; other site 216594007896 catalytic Zn binding site [ion binding]; other site 216594007897 structural Zn binding site [ion binding]; other site 216594007898 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594007899 Cytochrome P450; Region: p450; cl12078 216594007900 Nitronate monooxygenase; Region: NMO; pfam03060 216594007901 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216594007902 FMN binding site [chemical binding]; other site 216594007903 substrate binding site [chemical binding]; other site 216594007904 putative catalytic residue [active] 216594007905 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594007906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594007907 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594007908 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216594007909 NAD(P) binding site [chemical binding]; other site 216594007910 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594007911 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594007912 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 216594007913 putative active site [active] 216594007914 dimerization interface [polypeptide binding]; other site 216594007915 putative tRNAtyr binding site [nucleotide binding]; other site 216594007916 Domain of unknown function DUF77; Region: DUF77; pfam01910 216594007917 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 216594007918 putative ADP-ribose binding site [chemical binding]; other site 216594007919 competence damage-inducible protein A; Provisional; Region: PRK00549 216594007920 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 216594007921 putative MPT binding site; other site 216594007922 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 216594007923 putative sialic acid transporter; Region: 2A0112; TIGR00891 216594007924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594007925 putative substrate translocation pore; other site 216594007926 MURD63; Overlaps a putative amidohydrolase 216594007927 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594007928 Predicted membrane protein [Function unknown]; Region: COG1950 216594007929 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216594007930 anti sigma factor interaction site; other site 216594007931 regulatory phosphorylation site [posttranslational modification]; other site 216594007932 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216594007933 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 216594007934 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007935 PPE family; Region: PPE; pfam00823 216594007936 MURD64; Overlaps two hypothetical membrane proteins 216594007937 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 216594007938 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 216594007939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594007940 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216594007941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594007942 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216594007943 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594007944 NAD(P) binding site [chemical binding]; other site 216594007945 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 216594007946 putative hydrophobic ligand binding site [chemical binding]; other site 216594007947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594007948 dimerization interface [polypeptide binding]; other site 216594007949 putative DNA binding site [nucleotide binding]; other site 216594007950 putative Zn2+ binding site [ion binding]; other site 216594007951 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594007952 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216594007953 tetramer interface [polypeptide binding]; other site 216594007954 active site 216594007955 Mg2+/Mn2+ binding site [ion binding]; other site 216594007956 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 216594007957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007958 PPE family; Region: PPE; pfam00823 216594007959 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594007960 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594007961 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594007962 MURD65; No coding sequences detected 216594007963 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594007964 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 216594007965 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 216594007966 putative hydrophobic ligand binding site [chemical binding]; other site 216594007967 protein interface [polypeptide binding]; other site 216594007968 gate; other site 216594007969 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 216594007970 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594007971 putative acyl-acceptor binding pocket; other site 216594007972 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594007973 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594007974 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594007975 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594007976 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594007977 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 216594007978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594007980 Predicted ATPase [General function prediction only]; Region: COG3903 216594007981 MURD66; Overlaps a putative transcriptional regulator 216594007982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594007984 Predicted ATPase [General function prediction only]; Region: COG3903 216594007985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594007986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594007987 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 216594007988 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 216594007989 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594007990 acyl-activating enzyme (AAE) consensus motif; other site 216594007991 active site 216594007992 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216594007993 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216594007994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216594007995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594007996 Coenzyme A binding pocket [chemical binding]; other site 216594007997 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 216594007998 Phosphotransferase enzyme family; Region: APH; pfam01636 216594007999 putative active site [active] 216594008000 putative substrate binding site [chemical binding]; other site 216594008001 ATP binding site [chemical binding]; other site 216594008002 MURD67; Contains MPT63 - an extracellular immunodominant antigen in MTB. This MURD also contains hypothetical membrane proteins and an arylsulphatase orthologue 216594008003 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 216594008004 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594008005 Sulfatase; Region: Sulfatase; pfam00884 216594008006 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 216594008007 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 216594008008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 216594008009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 216594008010 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 216594008011 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 216594008012 active site 216594008013 putative substrate binding pocket [chemical binding]; other site 216594008014 peroxiredoxin; Provisional; Region: PRK13189 216594008015 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 216594008016 dimer interface [polypeptide binding]; other site 216594008017 decamer (pentamer of dimers) interface [polypeptide binding]; other site 216594008018 catalytic triad [active] 216594008019 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 216594008020 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 216594008021 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 216594008022 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 216594008023 short chain dehydrogenase; Provisional; Region: PRK05867 216594008024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008025 NAD(P) binding site [chemical binding]; other site 216594008026 active site 216594008027 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594008028 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594008029 RibD C-terminal domain; Region: RibD_C; cl17279 216594008030 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 216594008031 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 216594008032 conserved cys residue [active] 216594008033 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216594008034 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216594008035 conserved cys residue [active] 216594008036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216594008037 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216594008038 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 216594008039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594008040 Radical SAM superfamily; Region: Radical_SAM; pfam04055 216594008041 FeS/SAM binding site; other site 216594008042 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 216594008043 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 216594008044 dimer interface [polypeptide binding]; other site 216594008045 catalytic triad [active] 216594008046 peroxidatic and resolving cysteines [active] 216594008047 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594008048 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594008049 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594008050 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 216594008051 active site 216594008052 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 216594008053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594008054 FAD binding site [chemical binding]; other site 216594008055 substrate binding site [chemical binding]; other site 216594008056 catalytic base [active] 216594008057 enoyl-CoA hydratase; Provisional; Region: PRK08290 216594008058 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594008059 substrate binding site [chemical binding]; other site 216594008060 oxyanion hole (OAH) forming residues; other site 216594008061 trimer interface [polypeptide binding]; other site 216594008062 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594008063 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594008064 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 216594008065 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594008066 catalytic loop [active] 216594008067 iron binding site [ion binding]; other site 216594008068 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 216594008069 FAD binding pocket [chemical binding]; other site 216594008070 FAD binding motif [chemical binding]; other site 216594008071 phosphate binding motif [ion binding]; other site 216594008072 beta-alpha-beta structure motif; other site 216594008073 NAD binding pocket [chemical binding]; other site 216594008074 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594008075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594008076 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594008077 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 216594008078 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 216594008079 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 216594008080 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 216594008081 dimerization interface [polypeptide binding]; other site 216594008082 active site 216594008083 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 216594008084 putative NAD(P) binding site [chemical binding]; other site 216594008085 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 216594008086 active site 216594008087 homodimer interface [polypeptide binding]; other site 216594008088 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 216594008089 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594008090 putative Zn2+ binding site [ion binding]; other site 216594008091 putative DNA binding site [nucleotide binding]; other site 216594008092 dimerization interface [polypeptide binding]; other site 216594008093 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216594008094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008098 SCP-2 sterol transfer family; Region: SCP2; cl01225 216594008099 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594008100 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 216594008101 NAD(P) binding site [chemical binding]; other site 216594008102 catalytic residues [active] 216594008103 GAF domain; Region: GAF; cl17456 216594008104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594008105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594008106 DNA binding residues [nucleotide binding] 216594008107 dimerization interface [polypeptide binding]; other site 216594008108 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594008109 Cytochrome P450; Region: p450; cl12078 216594008110 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594008111 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 216594008112 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 216594008113 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594008114 Permease; Region: Permease; pfam02405 216594008115 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594008116 Permease; Region: Permease; pfam02405 216594008117 mce related protein; Region: MCE; pfam02470 216594008118 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594008119 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594008120 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594008121 mce related protein; Region: MCE; pfam02470 216594008122 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594008123 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594008124 mce related protein; Region: MCE; pfam02470 216594008125 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 216594008126 mce related protein; Region: MCE; pfam02470 216594008127 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 216594008128 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594008129 mce related protein; Region: MCE; pfam02470 216594008130 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594008131 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594008132 mce related protein; Region: MCE; pfam02470 216594008133 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 216594008134 MURD68; Contains 8 CDS encoding proteins of unknown function, many predicted to be membrane-associated, inlcuding a PE and a PPE family protein 216594008135 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594008136 YacP-like NYN domain; Region: NYN_YacP; cl01491 216594008137 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594008138 PPE family; Region: PPE; pfam00823 216594008139 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216594008140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008141 NAD(P) binding site [chemical binding]; other site 216594008142 active site 216594008143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008144 active site 216594008145 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 216594008146 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 216594008147 active site 216594008148 catalytic residues [active] 216594008149 MURD69; Contains 6 CDS of unknown function but predicted protein domain homologies to SERPINS and Zn-proteases suggest proteolytic functions 216594008150 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 216594008151 Prostaglandin dehydrogenases; Region: PGDH; cd05288 216594008152 NAD(P) binding site [chemical binding]; other site 216594008153 substrate binding site [chemical binding]; other site 216594008154 dimer interface [polypeptide binding]; other site 216594008155 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594008156 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 216594008157 Peptidase family M48; Region: Peptidase_M48; pfam01435 216594008158 Cutinase; Region: Cutinase; pfam01083 216594008159 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 216594008160 MURD70; Contains a single CDS encoding a hypothetical hydrolase 216594008161 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594008162 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 216594008163 nucleophilic elbow; other site 216594008164 catalytic triad; other site 216594008165 BCCT family transporter; Region: BCCT; pfam02028 216594008166 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 216594008167 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 216594008168 heme binding site [chemical binding]; other site 216594008169 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 216594008170 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216594008171 metal binding site 2 [ion binding]; metal-binding site 216594008172 putative DNA binding helix; other site 216594008173 metal binding site 1 [ion binding]; metal-binding site 216594008174 dimer interface [polypeptide binding]; other site 216594008175 structural Zn2+ binding site [ion binding]; other site 216594008176 Domain of unknown function (DUF385); Region: DUF385; cl04387 216594008177 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 216594008178 MURD71; function unknown; however this locus contains mmaA2 _1, a paralogous gene encoding a copy of methoxy mycolic acid synthase. Other genes in this region encode other methylases, glycosyltransferases and putative transport proteins. Region also overlaps the 5' end of a PPE gene 216594008179 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 216594008180 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 216594008181 active site residue [active] 216594008182 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 216594008183 active site residue [active] 216594008184 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 216594008185 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594008186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594008187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594008188 S-adenosylmethionine binding site [chemical binding]; other site 216594008189 Methyltransferase domain; Region: Methyltransf_24; pfam13578 216594008190 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 216594008191 Protein of unknown function, DUF608; Region: DUF608; pfam04685 216594008192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594008193 S-adenosylmethionine binding site [chemical binding]; other site 216594008194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594008195 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216594008196 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 216594008197 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216594008198 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594008199 active site 216594008200 metal binding site [ion binding]; metal-binding site 216594008201 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594008202 PPE family; Region: PPE; pfam00823 216594008203 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594008204 Short C-terminal domain; Region: SHOCT; pfam09851 216594008205 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594008206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594008207 Cytochrome P450; Region: p450; cl12078 216594008208 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 216594008209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594008210 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 216594008211 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 216594008212 PE family; Region: PE; pfam00934 216594008213 Cutinase; Region: Cutinase; pfam01083 216594008214 YcaO-like family; Region: YcaO; pfam02624 216594008215 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216594008216 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594008217 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594008218 acyl-activating enzyme (AAE) consensus motif; other site 216594008219 acyl-activating enzyme (AAE) consensus motif; other site 216594008220 AMP binding site [chemical binding]; other site 216594008221 active site 216594008222 CoA binding site [chemical binding]; other site 216594008223 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008224 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 216594008225 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 216594008226 putative NAD(P) binding site [chemical binding]; other site 216594008227 active site 216594008228 putative substrate binding site [chemical binding]; other site 216594008229 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 216594008230 putative catalytic residue [active] 216594008231 Nitroreductase family; Region: Nitroreductase; pfam00881 216594008232 FMN binding site [chemical binding]; other site 216594008233 dimer interface [polypeptide binding]; other site 216594008234 MURD72; Overlaps a single hypothetical regulatory protein 216594008235 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216594008236 MarR family; Region: MarR; pfam01047 216594008237 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 216594008238 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216594008239 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594008240 active site 216594008241 ATP binding site [chemical binding]; other site 216594008242 substrate binding site [chemical binding]; other site 216594008243 activation loop (A-loop); other site 216594008244 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594008245 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594008246 ligand binding site [chemical binding]; other site 216594008247 flexible hinge region; other site 216594008248 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594008249 PPE family; Region: PPE; pfam00823 216594008250 D-cysteine desulfhydrase; Validated; Region: PRK03910 216594008251 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 216594008252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594008253 catalytic residue [active] 216594008254 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 216594008255 oligomer interface [polypeptide binding]; other site 216594008256 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 216594008257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594008258 ATP binding site [chemical binding]; other site 216594008259 putative Mg++ binding site [ion binding]; other site 216594008260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594008261 nucleotide binding region [chemical binding]; other site 216594008262 ATP-binding site [chemical binding]; other site 216594008263 Helicase associated domain (HA2); Region: HA2; pfam04408 216594008264 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 216594008265 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 216594008266 PE family; Region: PE; pfam00934 216594008267 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216594008268 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216594008269 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 216594008270 putative NAD(P) binding site [chemical binding]; other site 216594008271 Cellulose binding domain; Region: CBM_2; pfam00553 216594008272 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 216594008273 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216594008274 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 216594008275 active site 216594008276 choline dehydrogenase; Validated; Region: PRK02106 216594008277 lycopene cyclase; Region: lycopene_cycl; TIGR01789 216594008278 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594008279 MURD73; Contains genes whose products include oxidoreductases, membrane proteins and regulatory proteins. This locus may play a role in electron transport 216594008280 PemK-like protein; Region: PemK; pfam02452 216594008281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594008282 ABC transporter signature motif; other site 216594008283 Walker B; other site 216594008284 D-loop; other site 216594008285 H-loop/switch region; other site 216594008286 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594008287 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216594008288 NAD(P) binding site [chemical binding]; other site 216594008289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008291 hypothetical protein; Provisional; Region: PRK02237 216594008292 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594008293 cyclase homology domain; Region: CHD; cd07302 216594008294 nucleotidyl binding site; other site 216594008295 metal binding site [ion binding]; metal-binding site 216594008296 dimer interface [polypeptide binding]; other site 216594008297 Predicted ATPase [General function prediction only]; Region: COG3903 216594008298 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594008299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594008300 DNA binding residues [nucleotide binding] 216594008301 dimerization interface [polypeptide binding]; other site 216594008302 Uncharacterized conserved protein [Function unknown]; Region: COG3349 216594008303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594008304 putative substrate translocation pore; other site 216594008305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594008306 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594008307 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594008308 ligand binding site [chemical binding]; other site 216594008309 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216594008310 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 216594008311 nucleophile elbow; other site 216594008312 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 216594008313 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216594008314 active site 216594008315 nucleotide binding site [chemical binding]; other site 216594008316 HIGH motif; other site 216594008317 KMSKS motif; other site 216594008318 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 216594008319 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594008320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594008321 putative substrate translocation pore; other site 216594008322 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 216594008323 putative catalytic residues [active] 216594008324 Hemerythrin-like domain; Region: Hr-like; cd12108 216594008325 Fe binding site [ion binding]; other site 216594008326 MURD74; This region is directly downstream of MURD73 and contains 3 PE-PGRS family genes together with CDS encoding a putative O-methyltransferase and a sugar transporter 216594008327 PE family; Region: PE; pfam00934 216594008328 PE family; Region: PE; pfam00934 216594008329 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594008330 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 216594008331 Cupin; Region: Cupin_1; smart00835 216594008332 Cupin; Region: Cupin_1; smart00835 216594008333 PE family; Region: PE; pfam00934 216594008334 enoyl-CoA hydratase; Provisional; Region: PRK08260 216594008335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594008336 substrate binding site [chemical binding]; other site 216594008337 oxyanion hole (OAH) forming residues; other site 216594008338 trimer interface [polypeptide binding]; other site 216594008339 Predicted membrane protein [Function unknown]; Region: COG4325 216594008340 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 216594008341 MURD75; This region is immediately d/s of MURD74 and harbours CDS encoding a cytochrome P450 CYTOCHROME P450 Cyp135B2, a putative thioesterase and other proteins that may be involved in lipid degradation 216594008342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594008343 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 216594008344 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594008345 active site 2 [active] 216594008346 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594008347 Cytochrome P450; Region: p450; cl12078 216594008348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008350 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 216594008351 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594008352 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 216594008353 homotetramer interface [polypeptide binding]; other site 216594008354 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594008355 NAD binding site [chemical binding]; other site 216594008356 homodimer interface [polypeptide binding]; other site 216594008357 active site 216594008358 Acyltransferase family; Region: Acyl_transf_3; pfam01757 216594008359 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 216594008360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594008361 Ligand Binding Site [chemical binding]; other site 216594008362 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594008363 Ligand Binding Site [chemical binding]; other site 216594008364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008366 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 216594008367 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 216594008368 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 216594008369 putative active site [active] 216594008370 putative metal binding site [ion binding]; other site 216594008371 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216594008372 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 216594008373 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594008374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216594008375 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216594008376 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216594008377 DNA binding residues [nucleotide binding] 216594008378 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216594008379 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 216594008380 putative dimer interface [polypeptide binding]; other site 216594008381 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 216594008382 active site 216594008383 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594008384 Ligand Binding Site [chemical binding]; other site 216594008385 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594008386 Ligand Binding Site [chemical binding]; other site 216594008387 Ferredoxin [Energy production and conversion]; Region: COG1146 216594008388 4Fe-4S binding domain; Region: Fer4; cl02805 216594008389 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594008390 Ligand Binding Site [chemical binding]; other site 216594008391 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594008392 Ligand Binding Site [chemical binding]; other site 216594008393 Putative zinc-finger; Region: zf-HC2; pfam13490 216594008394 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216594008395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594008396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594008397 DNA binding residues [nucleotide binding] 216594008398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594008399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594008400 OsmC-like protein; Region: OsmC; pfam02566 216594008401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 216594008402 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594008403 PPE family; Region: PPE; pfam00823 216594008404 PE family; Region: PE; pfam00934 216594008405 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594008406 PPE family; Region: PPE; pfam00823 216594008407 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594008408 PPE family; Region: PPE; pfam00823 216594008409 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 216594008410 PE family; Region: PE; pfam00934 216594008411 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216594008412 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 216594008413 nucleophile elbow; other site 216594008414 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216594008415 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216594008416 Walker A/P-loop; other site 216594008417 ATP binding site [chemical binding]; other site 216594008418 Q-loop/lid; other site 216594008419 ABC transporter signature motif; other site 216594008420 Walker B; other site 216594008421 D-loop; other site 216594008422 H-loop/switch region; other site 216594008423 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216594008424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594008425 dimer interface [polypeptide binding]; other site 216594008426 conserved gate region; other site 216594008427 putative PBP binding loops; other site 216594008428 ABC-ATPase subunit interface; other site 216594008429 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216594008430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594008431 dimer interface [polypeptide binding]; other site 216594008432 conserved gate region; other site 216594008433 putative PBP binding loops; other site 216594008434 ABC-ATPase subunit interface; other site 216594008435 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216594008436 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216594008437 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 216594008438 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 216594008439 Isochorismatase family; Region: Isochorismatase; pfam00857 216594008440 catalytic triad [active] 216594008441 metal binding site [ion binding]; metal-binding site 216594008442 conserved cis-peptide bond; other site 216594008443 Predicted membrane protein [Function unknown]; Region: COG2259 216594008444 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 216594008445 AAA domain; Region: AAA_33; pfam13671 216594008446 ATP-binding site [chemical binding]; other site 216594008447 Gluconate-6-phosphate binding site [chemical binding]; other site 216594008448 Ecdysteroid kinase; Region: EcKinase; cl17738 216594008449 Phosphotransferase enzyme family; Region: APH; pfam01636 216594008450 Mating-type protein beta 1; Region: Mating_N; pfam12731 216594008451 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 216594008452 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594008453 substrate binding pocket [chemical binding]; other site 216594008454 catalytic triad [active] 216594008455 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 216594008456 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 216594008457 hypothetical protein; Provisional; Region: PRK05865 216594008458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008459 NAD(P) binding site [chemical binding]; other site 216594008460 active site 216594008461 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216594008462 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594008463 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594008464 active site 216594008465 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594008466 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594008467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008468 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594008469 Enoylreductase; Region: PKS_ER; smart00829 216594008470 NAD(P) binding site [chemical binding]; other site 216594008471 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594008472 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594008473 putative NADP binding site [chemical binding]; other site 216594008474 active site 216594008475 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594008476 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594008477 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594008478 active site 216594008479 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594008480 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594008481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008482 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594008483 Enoylreductase; Region: PKS_ER; smart00829 216594008484 NAD(P) binding site [chemical binding]; other site 216594008485 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594008486 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594008487 putative NADP binding site [chemical binding]; other site 216594008488 active site 216594008489 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594008490 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 216594008491 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 216594008492 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 216594008493 Ligand binding site; other site 216594008494 Putative Catalytic site; other site 216594008495 DXD motif; other site 216594008496 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 216594008497 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 216594008498 putative active site [active] 216594008499 catalytic triad [active] 216594008500 putative dimer interface [polypeptide binding]; other site 216594008501 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 216594008502 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594008503 active site 216594008504 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 216594008505 Dienelactone hydrolase family; Region: DLH; pfam01738 216594008506 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 216594008507 Domain of unknown function (DUF389); Region: DUF389; pfam04087 216594008508 Uncharacterized conserved protein [Function unknown]; Region: COG2966 216594008509 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 216594008510 Uncharacterized conserved protein [Function unknown]; Region: COG3610 216594008511 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 216594008512 conserved cys residue [active] 216594008513 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 216594008514 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 216594008515 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 216594008516 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 216594008517 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 216594008518 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 216594008519 Moco binding site; other site 216594008520 metal coordination site [ion binding]; other site 216594008521 short chain dehydrogenase; Provisional; Region: PRK07825 216594008522 classical (c) SDRs; Region: SDR_c; cd05233 216594008523 NAD(P) binding site [chemical binding]; other site 216594008524 active site 216594008525 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 216594008526 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594008527 cyclase homology domain; Region: CHD; cd07302 216594008528 nucleotidyl binding site; other site 216594008529 metal binding site [ion binding]; metal-binding site 216594008530 dimer interface [polypeptide binding]; other site 216594008531 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594008532 cyclase homology domain; Region: CHD; cd07302 216594008533 nucleotidyl binding site; other site 216594008534 metal binding site [ion binding]; metal-binding site 216594008535 dimer interface [polypeptide binding]; other site 216594008536 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 216594008537 AAA ATPase domain; Region: AAA_16; pfam13191 216594008538 precorrin-3B synthase; Region: CobG; TIGR02435 216594008539 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216594008540 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216594008541 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 216594008542 Precorrin-8X methylmutase; Region: CbiC; pfam02570 216594008543 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 216594008544 active site 216594008545 SAM binding site [chemical binding]; other site 216594008546 homodimer interface [polypeptide binding]; other site 216594008547 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 216594008548 active site 216594008549 SAM binding site [chemical binding]; other site 216594008550 homodimer interface [polypeptide binding]; other site 216594008551 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594008552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594008553 S-adenosylmethionine binding site [chemical binding]; other site 216594008554 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 216594008555 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594008556 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594008557 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 216594008558 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 216594008559 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 216594008560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594008561 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216594008562 DNA binding residues [nucleotide binding] 216594008563 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 216594008564 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 216594008565 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 216594008566 active site 216594008567 SAM binding site [chemical binding]; other site 216594008568 homodimer interface [polypeptide binding]; other site 216594008569 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 216594008570 active site 216594008571 putative homodimer interface [polypeptide binding]; other site 216594008572 SAM binding site [chemical binding]; other site 216594008573 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 216594008574 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 216594008575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008576 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216594008577 NAD(P) binding site [chemical binding]; other site 216594008578 active site 216594008579 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 216594008580 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 216594008581 active site 216594008582 catalytic site [active] 216594008583 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 216594008584 ligand binding surface [chemical binding]; other site 216594008585 chromosome segregation protein; Provisional; Region: PRK02224 216594008586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 216594008587 P-loop containing region of AAA domain; Region: AAA_29; cl17516 216594008588 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 216594008589 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 216594008590 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 216594008591 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594008592 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594008593 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216594008594 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216594008595 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 216594008596 active site 216594008597 5'-3' exonuclease; Region: 53EXOc; smart00475 216594008598 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 216594008599 active site 216594008600 metal binding site 1 [ion binding]; metal-binding site 216594008601 putative 5' ssDNA interaction site; other site 216594008602 metal binding site 3; metal-binding site 216594008603 metal binding site 2 [ion binding]; metal-binding site 216594008604 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 216594008605 putative DNA binding site [nucleotide binding]; other site 216594008606 putative metal binding site [ion binding]; other site 216594008607 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 216594008608 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 216594008609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594008610 ATP binding site [chemical binding]; other site 216594008611 putative Mg++ binding site [ion binding]; other site 216594008612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594008613 nucleotide binding region [chemical binding]; other site 216594008614 ATP-binding site [chemical binding]; other site 216594008615 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 216594008616 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 216594008617 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 216594008618 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 216594008619 Predicted transcriptional regulator [Transcription]; Region: COG2378 216594008620 WYL domain; Region: WYL; pfam13280 216594008621 Predicted transcriptional regulator [Transcription]; Region: COG2378 216594008622 WYL domain; Region: WYL; pfam13280 216594008623 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 216594008624 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 216594008625 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 216594008626 active site 216594008627 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 216594008628 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 216594008629 active site 216594008630 Pup-like protein; Region: Pup; cl05289 216594008631 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 216594008632 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 216594008633 proteasome ATPase; Region: pup_AAA; TIGR03689 216594008634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594008635 Walker A motif; other site 216594008636 ATP binding site [chemical binding]; other site 216594008637 Walker B motif; other site 216594008638 arginine finger; other site 216594008639 Protein of unknown function (DUF503); Region: DUF503; cl00669 216594008640 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 216594008641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594008642 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 216594008643 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 216594008644 Condensation domain; Region: Condensation; pfam00668 216594008645 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008646 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008647 acyl-activating enzyme (AAE) consensus motif; other site 216594008648 AMP binding site [chemical binding]; other site 216594008649 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008650 Condensation domain; Region: Condensation; pfam00668 216594008651 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008652 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594008653 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008654 acyl-activating enzyme (AAE) consensus motif; other site 216594008655 AMP binding site [chemical binding]; other site 216594008656 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008657 Condensation domain; Region: Condensation; pfam00668 216594008658 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008659 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594008660 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008661 acyl-activating enzyme (AAE) consensus motif; other site 216594008662 AMP binding site [chemical binding]; other site 216594008663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008664 Condensation domain; Region: Condensation; pfam00668 216594008665 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008666 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594008667 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008668 acyl-activating enzyme (AAE) consensus motif; other site 216594008669 AMP binding site [chemical binding]; other site 216594008670 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008671 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 216594008672 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594008673 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008674 acyl-activating enzyme (AAE) consensus motif; other site 216594008675 AMP binding site [chemical binding]; other site 216594008676 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008677 MURD76; Spans a 5-module NRP, metabolite unknown 216594008678 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594008679 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594008680 active site 216594008681 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594008682 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594008683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008684 Enoylreductase; Region: PKS_ER; smart00829 216594008685 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594008686 NAD(P) binding site [chemical binding]; other site 216594008687 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594008688 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594008689 putative NADP binding site [chemical binding]; other site 216594008690 active site 216594008691 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594008692 Condensation domain; Region: Condensation; pfam00668 216594008693 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008694 MURD77; This region is immediately adjacent to MURD76. It overlaps a single-module PKS (acetate, full reduction), the product of which is probably linked to the adjacent single-module PKS and the following NRP locus within MURD76 216594008695 acyl-CoA synthetase; Validated; Region: PRK05850 216594008696 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594008697 acyl-activating enzyme (AAE) consensus motif; other site 216594008698 active site 216594008699 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594008700 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594008701 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594008702 active site 216594008703 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594008704 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594008705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594008706 Enoylreductase; Region: PKS_ER; smart00829 216594008707 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594008708 NAD(P) binding site [chemical binding]; other site 216594008709 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594008710 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594008711 putative NADP binding site [chemical binding]; other site 216594008712 active site 216594008713 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594008714 MURD78; Part of the preceding PKS/NRP cluster in MURD76 and MURD77; contains 2 CDS encoding an ErmB-like transporter and a hypothetical dehydrogenase 216594008715 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594008716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594008717 putative substrate translocation pore; other site 216594008718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594008719 mercuric reductase; Validated; Region: PRK06370 216594008720 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 216594008721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594008722 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216594008723 Predicted membrane protein [Function unknown]; Region: COG3918 216594008724 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 216594008725 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 216594008726 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 216594008727 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 216594008728 homodimer interface [polypeptide binding]; other site 216594008729 putative metal binding site [ion binding]; other site 216594008730 PE family; Region: PE; pfam00934 216594008731 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594008732 PPE family; Region: PPE; pfam00823 216594008733 PAC2 family; Region: PAC2; pfam09754 216594008734 hypothetical protein; Provisional; Region: PRK07588 216594008735 hypothetical protein; Provisional; Region: PRK07236 216594008736 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594008737 short chain dehydrogenase; Provisional; Region: PRK05872 216594008738 classical (c) SDRs; Region: SDR_c; cd05233 216594008739 NAD(P) binding site [chemical binding]; other site 216594008740 active site 216594008741 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216594008742 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 216594008743 active site 216594008744 HIGH motif; other site 216594008745 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216594008746 active site 216594008747 KMSKS motif; other site 216594008748 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 216594008749 putative tRNA binding surface [nucleotide binding]; other site 216594008750 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594008751 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 216594008752 NAD(P) binding site [chemical binding]; other site 216594008753 catalytic residues [active] 216594008754 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 216594008755 active site 216594008756 conserved hypothetical protein; Region: TIGR03843 216594008757 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 216594008758 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594008759 catalytic core [active] 216594008760 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 216594008761 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 216594008762 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 216594008763 quinone interaction residues [chemical binding]; other site 216594008764 active site 216594008765 catalytic residues [active] 216594008766 FMN binding site [chemical binding]; other site 216594008767 substrate binding site [chemical binding]; other site 216594008768 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594008769 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594008770 active site 216594008771 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 216594008772 substrate binding site [chemical binding]; other site 216594008773 hypothetical protein; Provisional; Region: PRK07906 216594008774 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 216594008775 putative metal binding site [ion binding]; other site 216594008776 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216594008777 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 216594008778 catalytic residues [active] 216594008779 catalytic nucleophile [active] 216594008780 Recombinase; Region: Recombinase; pfam07508 216594008781 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 216594008782 bacteriophage phiMmar08; MURD79; putative prophage, insertion near tRNA, presence of integrase, replication and partioning genes. This region also harbours genes encoding CDS involved in beta- oxidation, 2 cytochrome P450s and 3 putative monooxygenases in an operon-like structure 216594008783 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594008784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594008785 non-specific DNA binding site [nucleotide binding]; other site 216594008786 salt bridge; other site 216594008787 sequence-specific DNA binding site [nucleotide binding]; other site 216594008788 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 216594008789 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 216594008790 nudix motif; other site 216594008791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216594008792 Zn2+ binding site [ion binding]; other site 216594008793 Mg2+ binding site [ion binding]; other site 216594008794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594008795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594008796 active site 216594008797 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 216594008798 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 216594008799 dimer interface [polypeptide binding]; other site 216594008800 acyl-activating enzyme (AAE) consensus motif; other site 216594008801 putative active site [active] 216594008802 AMP binding site [chemical binding]; other site 216594008803 putative CoA binding site [chemical binding]; other site 216594008804 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216594008805 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216594008806 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 216594008807 Cytochrome P450; Region: p450; cl12078 216594008808 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594008809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594008810 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594008811 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594008812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594008813 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594008814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594008815 classical (c) SDRs; Region: SDR_c; cd05233 216594008816 short chain dehydrogenase; Provisional; Region: PRK05650 216594008817 NAD(P) binding site [chemical binding]; other site 216594008818 active site 216594008819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008821 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 216594008822 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 216594008823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008825 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594008826 subunit interaction site [polypeptide binding]; other site 216594008827 PHB binding site; other site 216594008828 CoenzymeA binding site [chemical binding]; other site 216594008829 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 216594008830 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 216594008831 putative active site [active] 216594008832 putative transposase OrfB; Reviewed; Region: PHA02517 216594008833 HTH-like domain; Region: HTH_21; pfam13276 216594008834 Integrase core domain; Region: rve; pfam00665 216594008835 Integrase core domain; Region: rve_3; pfam13683 216594008836 Transposase; Region: HTH_Tnp_1; pfam01527 216594008837 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 216594008838 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 216594008839 NAD binding site [chemical binding]; other site 216594008840 catalytic Zn binding site [ion binding]; other site 216594008841 substrate binding site [chemical binding]; other site 216594008842 structural Zn binding site [ion binding]; other site 216594008843 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 216594008844 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 216594008845 dimer interface [polypeptide binding]; other site 216594008846 acyl-activating enzyme (AAE) consensus motif; other site 216594008847 putative active site [active] 216594008848 AMP binding site [chemical binding]; other site 216594008849 putative CoA binding site [chemical binding]; other site 216594008850 SCP-2 sterol transfer family; Region: SCP2; pfam02036 216594008851 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 216594008852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594008853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594008854 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594008855 Cytochrome P450; Region: p450; cl12078 216594008856 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216594008857 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594008858 catalytic loop [active] 216594008859 iron binding site [ion binding]; other site 216594008860 Uncharacterized ACR, COG1753; Region: DUF217; cl00762 216594008861 Helix-turn-helix domain; Region: HTH_18; pfam12833 216594008862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216594008863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008865 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594008866 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594008867 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594008868 CoenzymeA binding site [chemical binding]; other site 216594008869 subunit interaction site [polypeptide binding]; other site 216594008870 PHB binding site; other site 216594008871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594008872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594008873 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 216594008874 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 216594008875 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216594008876 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594008877 NAD(P) binding site [chemical binding]; other site 216594008878 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216594008879 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216594008880 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 216594008881 putative active site [active] 216594008882 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594008883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594008884 S-adenosylmethionine binding site [chemical binding]; other site 216594008885 MbtH-like protein; Region: MbtH; pfam03621 216594008886 Transport protein; Region: actII; TIGR00833 216594008887 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594008888 Condensation domain; Region: Condensation; pfam00668 216594008889 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008890 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594008891 acyl-activating enzyme (AAE) consensus motif; other site 216594008892 AMP binding site [chemical binding]; other site 216594008893 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594008894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594008895 S-adenosylmethionine binding site [chemical binding]; other site 216594008896 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594008897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008898 Condensation domain; Region: Condensation; pfam00668 216594008899 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008900 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594008901 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008902 acyl-activating enzyme (AAE) consensus motif; other site 216594008903 AMP binding site [chemical binding]; other site 216594008904 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594008905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594008906 S-adenosylmethionine binding site [chemical binding]; other site 216594008907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594008908 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008909 Condensation domain; Region: Condensation; pfam00668 216594008910 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008911 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594008912 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008913 acyl-activating enzyme (AAE) consensus motif; other site 216594008914 AMP binding site [chemical binding]; other site 216594008915 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008916 Condensation domain; Region: Condensation; pfam00668 216594008917 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008918 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594008919 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008920 acyl-activating enzyme (AAE) consensus motif; other site 216594008921 AMP binding site [chemical binding]; other site 216594008922 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008923 Condensation domain; Region: Condensation; pfam00668 216594008924 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594008925 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594008926 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594008927 acyl-activating enzyme (AAE) consensus motif; other site 216594008928 AMP binding site [chemical binding]; other site 216594008929 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594008930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594008931 S-adenosylmethionine binding site [chemical binding]; other site 216594008932 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594008933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594008934 Thioesterase domain; Region: Thioesterase; pfam00975 216594008935 MURD80; Contains a CDS encoding a 5-module NRP 216594008936 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 216594008937 tetramerization interface [polypeptide binding]; other site 216594008938 active site 216594008939 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594008940 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 216594008941 putative active site [active] 216594008942 DivIVA domain; Region: DivI1A_domain; TIGR03544 216594008943 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 216594008944 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 216594008945 Predicted integral membrane protein [Function unknown]; Region: COG0762 216594008946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 216594008947 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 216594008948 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216594008949 catalytic residue [active] 216594008950 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 216594008951 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 216594008952 cell division protein FtsZ; Validated; Region: PRK09330 216594008953 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 216594008954 nucleotide binding site [chemical binding]; other site 216594008955 SulA interaction site; other site 216594008956 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 216594008957 Cell division protein FtsQ; Region: FtsQ; pfam03799 216594008958 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 216594008959 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216594008960 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216594008961 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216594008962 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 216594008963 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 216594008964 active site 216594008965 homodimer interface [polypeptide binding]; other site 216594008966 cell division protein FtsW; Region: ftsW; TIGR02614 216594008967 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 216594008968 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216594008969 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216594008970 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 216594008971 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 216594008972 Mg++ binding site [ion binding]; other site 216594008973 putative catalytic motif [active] 216594008974 putative substrate binding site [chemical binding]; other site 216594008975 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216594008976 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216594008977 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 216594008978 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216594008979 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216594008980 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216594008981 PE family; Region: PE; pfam00934 216594008982 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 216594008983 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216594008984 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216594008985 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 216594008986 MraW methylase family; Region: Methyltransf_5; cl17771 216594008987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 216594008988 MraZ protein; Region: MraZ; pfam02381 216594008989 MraZ protein; Region: MraZ; pfam02381 216594008990 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 216594008991 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216594008992 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216594008993 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216594008994 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216594008995 substrate binding pocket [chemical binding]; other site 216594008996 chain length determination region; other site 216594008997 substrate-Mg2+ binding site; other site 216594008998 catalytic residues [active] 216594008999 aspartate-rich region 1; other site 216594009000 active site lid residues [active] 216594009001 aspartate-rich region 2; other site 216594009002 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 216594009003 Helix-turn-helix domain; Region: HTH_17; cl17695 216594009004 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594009005 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594009006 active site 216594009007 ATP binding site [chemical binding]; other site 216594009008 substrate binding site [chemical binding]; other site 216594009009 activation loop (A-loop); other site 216594009010 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216594009011 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216594009012 substrate binding pocket [chemical binding]; other site 216594009013 chain length determination region; other site 216594009014 substrate-Mg2+ binding site; other site 216594009015 catalytic residues [active] 216594009016 aspartate-rich region 1; other site 216594009017 active site lid residues [active] 216594009018 aspartate-rich region 2; other site 216594009019 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 216594009020 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 216594009021 dimer interface [polypeptide binding]; other site 216594009022 active site 216594009023 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 216594009024 homodimer interface [polypeptide binding]; other site 216594009025 substrate binding pocket [chemical binding]; other site 216594009026 catalytic residues [active] 216594009027 NADH/NADPH cofactor binding site [chemical binding]; other site 216594009028 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 216594009029 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 216594009030 diphosphomevalonate decarboxylase; Region: PLN02407 216594009031 diphosphomevalonate decarboxylase; Region: PLN02407 216594009032 mevalonate kinase; Region: mevalon_kin; TIGR00549 216594009033 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 216594009034 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 216594009035 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 216594009036 active site 216594009037 metal binding site [ion binding]; metal-binding site 216594009038 nudix motif; other site 216594009039 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216594009040 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216594009041 substrate binding pocket [chemical binding]; other site 216594009042 chain length determination region; other site 216594009043 substrate-Mg2+ binding site; other site 216594009044 catalytic residues [active] 216594009045 aspartate-rich region 1; other site 216594009046 active site lid residues [active] 216594009047 aspartate-rich region 2; other site 216594009048 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 216594009049 substrate binding pocket [chemical binding]; other site 216594009050 substrate-Mg2+ binding site; other site 216594009051 aspartate-rich region 1; other site 216594009052 aspartate-rich region 2; other site 216594009053 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216594009054 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216594009055 dimer interface [polypeptide binding]; other site 216594009056 active site 216594009057 CoA binding pocket [chemical binding]; other site 216594009058 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 216594009059 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 216594009060 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594009061 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216594009062 putative acyl-acceptor binding pocket; other site 216594009063 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 216594009064 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216594009065 DTAP/Switch II; other site 216594009066 Switch I; other site 216594009067 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 216594009068 putative hydrophobic ligand binding site [chemical binding]; other site 216594009069 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216594009070 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 216594009071 acyl-activating enzyme (AAE) consensus motif; other site 216594009072 putative AMP binding site [chemical binding]; other site 216594009073 putative active site [active] 216594009074 putative CoA binding site [chemical binding]; other site 216594009075 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216594009076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594009077 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 216594009078 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216594009079 NlpC/P60 family; Region: NLPC_P60; pfam00877 216594009080 hypothetical protein; Validated; Region: PRK07883 216594009081 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216594009082 active site 216594009083 substrate binding site [chemical binding]; other site 216594009084 catalytic site [active] 216594009085 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 216594009086 GIY-YIG motif/motif A; other site 216594009087 active site 216594009088 catalytic site [active] 216594009089 putative DNA binding site [nucleotide binding]; other site 216594009090 metal binding site [ion binding]; metal-binding site 216594009091 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 216594009092 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216594009093 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216594009094 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 216594009095 Subunit I/III interface [polypeptide binding]; other site 216594009096 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216594009097 Cytochrome c; Region: Cytochrom_C; pfam00034 216594009098 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 216594009099 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 216594009100 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 216594009101 iron-sulfur cluster [ion binding]; other site 216594009102 [2Fe-2S] cluster binding site [ion binding]; other site 216594009103 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 216594009104 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 216594009105 heme bH binding site [chemical binding]; other site 216594009106 intrachain domain interface; other site 216594009107 heme bL binding site [chemical binding]; other site 216594009108 interchain domain interface [polypeptide binding]; other site 216594009109 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 216594009110 Qo binding site; other site 216594009111 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 216594009112 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594009113 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 216594009114 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 216594009115 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 216594009116 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 216594009117 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 216594009118 dimer interface [polypeptide binding]; other site 216594009119 active site 216594009120 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 216594009121 Ligand Binding Site [chemical binding]; other site 216594009122 Molecular Tunnel; other site 216594009123 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 216594009124 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216594009125 substrate binding site [chemical binding]; other site 216594009126 ATP binding site [chemical binding]; other site 216594009127 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 216594009128 Glycerate kinase family; Region: Gly_kinase; pfam02595 216594009129 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 216594009130 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 216594009131 homotrimer interface [polypeptide binding]; other site 216594009132 Walker A motif; other site 216594009133 GTP binding site [chemical binding]; other site 216594009134 Walker B motif; other site 216594009135 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 216594009136 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 216594009137 active site pocket [active] 216594009138 putative dimer interface [polypeptide binding]; other site 216594009139 putative cataytic base [active] 216594009140 cobalamin synthase; Reviewed; Region: cobS; PRK00235 216594009141 MFS/sugar transport protein; Region: MFS_2; pfam13347 216594009142 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 216594009143 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 216594009144 homodimer interface [polypeptide binding]; other site 216594009145 substrate-cofactor binding pocket; other site 216594009146 catalytic residue [active] 216594009147 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 216594009148 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216594009149 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216594009150 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594009151 cyclase homology domain; Region: CHD; cd07302 216594009152 nucleotidyl binding site; other site 216594009153 metal binding site [ion binding]; metal-binding site 216594009154 dimer interface [polypeptide binding]; other site 216594009155 multifunctional aminopeptidase A; Provisional; Region: PRK00913 216594009156 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 216594009157 interface (dimer of trimers) [polypeptide binding]; other site 216594009158 Substrate-binding/catalytic site; other site 216594009159 Zn-binding sites [ion binding]; other site 216594009160 short chain dehydrogenase; Validated; Region: PRK05855 216594009161 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594009162 classical (c) SDRs; Region: SDR_c; cd05233 216594009163 NAD(P) binding site [chemical binding]; other site 216594009164 active site 216594009165 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216594009166 E3 interaction surface; other site 216594009167 lipoyl attachment site [posttranslational modification]; other site 216594009168 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216594009169 E3 interaction surface; other site 216594009170 lipoyl attachment site [posttranslational modification]; other site 216594009171 e3 binding domain; Region: E3_binding; pfam02817 216594009172 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 216594009173 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216594009174 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 216594009175 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 216594009176 putative NAD(P) binding site [chemical binding]; other site 216594009177 putative active site [active] 216594009178 MURD81; Overlaps a single CDS encoding a putative transport protein 216594009179 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216594009180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594009181 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 216594009182 Walker A/P-loop; other site 216594009183 ATP binding site [chemical binding]; other site 216594009184 Q-loop/lid; other site 216594009185 ABC transporter signature motif; other site 216594009186 Walker B; other site 216594009187 D-loop; other site 216594009188 H-loop/switch region; other site 216594009189 MURD82; Overlaps two CDS encoding MmpL family proteins 216594009190 Transport protein; Region: actII; TIGR00833 216594009191 MbtH-like protein; Region: MbtH; pfam03621 216594009192 Transport protein; Region: actII; TIGR00833 216594009193 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594009194 Condensation domain; Region: Condensation; pfam00668 216594009195 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009196 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009197 acyl-activating enzyme (AAE) consensus motif; other site 216594009198 AMP binding site [chemical binding]; other site 216594009199 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009200 Condensation domain; Region: Condensation; pfam00668 216594009201 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009202 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009203 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009204 acyl-activating enzyme (AAE) consensus motif; other site 216594009205 AMP binding site [chemical binding]; other site 216594009206 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009207 Condensation domain; Region: Condensation; pfam00668 216594009208 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594009209 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009210 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009211 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009212 acyl-activating enzyme (AAE) consensus motif; other site 216594009213 AMP binding site [chemical binding]; other site 216594009214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009215 Condensation domain; Region: Condensation; pfam00668 216594009216 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009217 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009218 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009219 acyl-activating enzyme (AAE) consensus motif; other site 216594009220 AMP binding site [chemical binding]; other site 216594009221 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009222 Condensation domain; Region: Condensation; pfam00668 216594009223 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009224 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009225 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009226 acyl-activating enzyme (AAE) consensus motif; other site 216594009227 AMP binding site [chemical binding]; other site 216594009228 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009229 Condensation domain; Region: Condensation; pfam00668 216594009230 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009231 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009232 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009233 acyl-activating enzyme (AAE) consensus motif; other site 216594009234 AMP binding site [chemical binding]; other site 216594009235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009236 Condensation domain; Region: Condensation; pfam00668 216594009237 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009238 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009239 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009240 acyl-activating enzyme (AAE) consensus motif; other site 216594009241 AMP binding site [chemical binding]; other site 216594009242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009243 Condensation domain; Region: Condensation; pfam00668 216594009244 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009245 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009246 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009247 acyl-activating enzyme (AAE) consensus motif; other site 216594009248 AMP binding site [chemical binding]; other site 216594009249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009250 Condensation domain; Region: Condensation; pfam00668 216594009251 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009252 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009253 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009254 acyl-activating enzyme (AAE) consensus motif; other site 216594009255 AMP binding site [chemical binding]; other site 216594009256 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009257 MURD83; Contains three very large CDS encoding NRP synthetases of 9,2 & 4 extension modules for production of unknown metabolite. Also contains a putative FAAL for ligation to other product. The region is immediately d/s of MURD82 (MmpL) 216594009258 Condensation domain; Region: Condensation; pfam00668 216594009259 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009260 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009261 acyl-activating enzyme (AAE) consensus motif; other site 216594009262 AMP binding site [chemical binding]; other site 216594009263 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009264 Condensation domain; Region: Condensation; pfam00668 216594009265 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009266 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009267 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009268 acyl-activating enzyme (AAE) consensus motif; other site 216594009269 AMP binding site [chemical binding]; other site 216594009270 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009271 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009272 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009273 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009274 acyl-activating enzyme (AAE) consensus motif; other site 216594009275 AMP binding site [chemical binding]; other site 216594009276 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009277 Condensation domain; Region: Condensation; pfam00668 216594009278 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009279 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009280 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009281 acyl-activating enzyme (AAE) consensus motif; other site 216594009282 AMP binding site [chemical binding]; other site 216594009283 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009284 Condensation domain; Region: Condensation; pfam00668 216594009285 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009286 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009287 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009288 acyl-activating enzyme (AAE) consensus motif; other site 216594009289 AMP binding site [chemical binding]; other site 216594009290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009291 Condensation domain; Region: Condensation; pfam00668 216594009292 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594009293 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594009294 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594009295 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594009296 acyl-activating enzyme (AAE) consensus motif; other site 216594009297 AMP binding site [chemical binding]; other site 216594009298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594009299 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 216594009300 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594009301 acyl-activating enzyme (AAE) consensus motif; other site 216594009302 AMP binding site [chemical binding]; other site 216594009303 active site 216594009304 CoA binding site [chemical binding]; other site 216594009305 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594009306 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 216594009307 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 216594009308 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 216594009309 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216594009310 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 216594009311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594009312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594009313 DNA binding residues [nucleotide binding] 216594009314 Putative zinc-finger; Region: zf-HC2; pfam13490 216594009315 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216594009316 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 216594009317 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 216594009318 acetolactate synthase; Reviewed; Region: PRK08322 216594009319 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216594009320 PYR/PP interface [polypeptide binding]; other site 216594009321 dimer interface [polypeptide binding]; other site 216594009322 TPP binding site [chemical binding]; other site 216594009323 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216594009324 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 216594009325 TPP-binding site [chemical binding]; other site 216594009326 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 216594009327 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216594009328 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216594009329 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 216594009330 Walker A/P-loop; other site 216594009331 ATP binding site [chemical binding]; other site 216594009332 Q-loop/lid; other site 216594009333 ABC transporter signature motif; other site 216594009334 Walker B; other site 216594009335 D-loop; other site 216594009336 H-loop/switch region; other site 216594009337 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216594009338 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216594009339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594009340 Walker A/P-loop; other site 216594009341 ATP binding site [chemical binding]; other site 216594009342 Q-loop/lid; other site 216594009343 ABC transporter signature motif; other site 216594009344 Walker B; other site 216594009345 D-loop; other site 216594009346 H-loop/switch region; other site 216594009347 lipoate-protein ligase B; Provisional; Region: PRK14345 216594009348 lipoyl synthase; Provisional; Region: PRK05481 216594009349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594009350 FeS/SAM binding site; other site 216594009351 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 216594009352 RDD family; Region: RDD; pfam06271 216594009353 glutamine synthetase, type I; Region: GlnA; TIGR00653 216594009354 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 216594009355 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216594009356 PE family; Region: PE; pfam00934 216594009357 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594009358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594009359 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594009360 CoenzymeA binding site [chemical binding]; other site 216594009361 subunit interaction site [polypeptide binding]; other site 216594009362 PHB binding site; other site 216594009363 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 216594009364 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216594009365 metal binding triad; other site 216594009366 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216594009367 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216594009368 metal binding triad; other site 216594009369 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216594009370 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216594009371 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 216594009372 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216594009373 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 216594009374 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594009375 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 216594009376 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 216594009377 D-pathway; other site 216594009378 Putative ubiquinol binding site [chemical binding]; other site 216594009379 Low-spin heme (heme b) binding site [chemical binding]; other site 216594009380 Putative water exit pathway; other site 216594009381 Binuclear center (heme o3/CuB) [ion binding]; other site 216594009382 K-pathway; other site 216594009383 Putative proton exit pathway; other site 216594009384 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 216594009385 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594009386 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594009387 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594009388 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 216594009389 oligomerization interface [polypeptide binding]; other site 216594009390 active site 216594009391 metal binding site [ion binding]; metal-binding site 216594009392 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 216594009393 putative active site; other site 216594009394 putative metal binding residues [ion binding]; other site 216594009395 signature motif; other site 216594009396 putative triphosphate binding site [ion binding]; other site 216594009397 CHAD domain; Region: CHAD; pfam05235 216594009398 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 216594009399 PE family; Region: PE; pfam00934 216594009400 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 216594009401 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 216594009402 RNA/DNA hybrid binding site [nucleotide binding]; other site 216594009403 active site 216594009404 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594009405 catalytic core [active] 216594009406 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 216594009407 Putative zinc ribbon domain; Region: DUF164; pfam02591 216594009408 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 216594009409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 216594009410 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 216594009411 hypothetical protein; Provisional; Region: PRK07908 216594009412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594009413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594009414 homodimer interface [polypeptide binding]; other site 216594009415 catalytic residue [active] 216594009416 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216594009417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594009418 motif II; other site 216594009419 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 216594009420 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216594009421 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 216594009422 active site 216594009423 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 216594009424 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 216594009425 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 216594009426 Cation efflux family; Region: Cation_efflux; cl00316 216594009427 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 216594009428 MURD84; Contains genes encoding two PE-PGRS family genes, pdhA and pdhB (pyruvate to Acetyl-CoA), other dehydrogenases, putative transcriptional regulators and hypothetical proteins 216594009429 Epoxide hydrolase N terminus; Region: EHN; pfam06441 216594009430 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594009431 PE family; Region: PE; pfam00934 216594009432 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 216594009433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594009434 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216594009435 NAD(P) binding site [chemical binding]; other site 216594009436 active site 216594009437 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216594009438 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216594009439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216594009440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594009441 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216594009442 active site 216594009443 metal binding site [ion binding]; metal-binding site 216594009444 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594009445 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 216594009446 active site 216594009447 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 216594009448 putative hydrophobic ligand binding site [chemical binding]; other site 216594009449 protein interface [polypeptide binding]; other site 216594009450 gate; other site 216594009451 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216594009452 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 216594009453 PYR/PP interface [polypeptide binding]; other site 216594009454 dimer interface [polypeptide binding]; other site 216594009455 TPP binding site [chemical binding]; other site 216594009456 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216594009457 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216594009458 tetramer interface [polypeptide binding]; other site 216594009459 TPP-binding site [chemical binding]; other site 216594009460 heterodimer interface [polypeptide binding]; other site 216594009461 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216594009462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594009463 NAD(P) binding site [chemical binding]; other site 216594009464 active site 216594009465 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 216594009466 PE family; Region: PE; pfam00934 216594009467 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 216594009468 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 216594009469 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216594009470 putative NAD(P) binding site [chemical binding]; other site 216594009471 catalytic Zn binding site [ion binding]; other site 216594009472 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594009473 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594009474 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594009475 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594009476 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 216594009477 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 216594009478 dimer interface [polypeptide binding]; other site 216594009479 catalytic triad [active] 216594009480 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 216594009481 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 216594009482 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 216594009483 dimer interface [polypeptide binding]; other site 216594009484 TPP-binding site [chemical binding]; other site 216594009485 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594009486 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594009487 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 216594009488 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594009489 acyl carrier protein; Provisional; Region: acpP; PRK00982 216594009490 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 216594009491 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216594009492 dimer interface [polypeptide binding]; other site 216594009493 active site 216594009494 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 216594009495 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216594009496 dimer interface [polypeptide binding]; other site 216594009497 active site 216594009498 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216594009499 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216594009500 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216594009501 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 216594009502 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 216594009503 putative active site [active] 216594009504 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 216594009505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594009506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594009507 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594009508 FAD binding domain; Region: FAD_binding_4; pfam01565 216594009509 diacylglycerol kinase; Reviewed; Region: PRK11914 216594009510 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 216594009511 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 216594009512 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594009513 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594009514 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594009515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594009516 S-adenosylmethionine binding site [chemical binding]; other site 216594009517 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 216594009518 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 216594009519 NAD binding site [chemical binding]; other site 216594009520 catalytic Zn binding site [ion binding]; other site 216594009521 substrate binding site [chemical binding]; other site 216594009522 structural Zn binding site [ion binding]; other site 216594009523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594009524 MURD85; Putative insertion sequence 216594009525 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 216594009526 Short C-terminal domain; Region: SHOCT; pfam09851 216594009527 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 216594009528 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 216594009529 putative active site [active] 216594009530 catalytic triad [active] 216594009531 putative dimer interface [polypeptide binding]; other site 216594009532 short chain dehydrogenase; Provisional; Region: PRK05854 216594009533 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 216594009534 putative NAD(P) binding site [chemical binding]; other site 216594009535 active site 216594009536 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 216594009537 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 216594009538 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216594009539 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 216594009540 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216594009541 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594009542 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594009543 Cytochrome P450; Region: p450; cl12078 216594009544 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 216594009545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594009546 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216594009547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594009548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594009549 S-adenosylmethionine binding site [chemical binding]; other site 216594009550 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216594009551 Predicted membrane protein [Function unknown]; Region: COG2149 216594009552 Domain of unknown function (DUF202); Region: DUF202; pfam02656 216594009553 Ion channel; Region: Ion_trans_2; pfam07885 216594009554 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 216594009555 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 216594009556 Transposase; Region: HTH_Tnp_1; pfam01527 216594009557 putative transposase OrfB; Reviewed; Region: PHA02517 216594009558 HTH-like domain; Region: HTH_21; pfam13276 216594009559 Integrase core domain; Region: rve; pfam00665 216594009560 Integrase core domain; Region: rve_3; pfam13683 216594009561 MURD86; Putative insertion sequence 216594009562 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 216594009563 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 216594009564 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594009565 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594009566 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 216594009567 active site 216594009568 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594009569 PPE family; Region: PPE; pfam00823 216594009570 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594009571 PPE family; Region: PPE; pfam00823 216594009572 Transposase; Region: HTH_Tnp_1; cl17663 216594009573 SIR2-like domain; Region: SIR2_2; pfam13289 216594009574 MURD87; Functions unknown. Contains genes encoding 2 PE- PGRS family proteins, PfkA (6-phophofructokinase involved in glycolysis) and hypothetical proteins with possible roles in intermediary metabolism 216594009575 Emopamil binding protein; Region: EBP; pfam05241 216594009576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594009577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594009578 NAD(P) binding site [chemical binding]; other site 216594009579 active site 216594009580 hypothetical protein; Provisional; Region: PRK06126 216594009581 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594009582 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594009583 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 216594009584 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594009585 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594009586 biotin carboxylase-like protein; Validated; Region: PRK06524 216594009587 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 216594009588 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216594009589 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 216594009590 acyl-activating enzyme (AAE) consensus motif; other site 216594009591 putative AMP binding site [chemical binding]; other site 216594009592 putative active site [active] 216594009593 putative CoA binding site [chemical binding]; other site 216594009594 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594009595 Domain of unknown function (DUF385); Region: DUF385; cl04387 216594009596 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594009597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594009598 S-adenosylmethionine binding site [chemical binding]; other site 216594009599 hypothetical protein; Provisional; Region: PRK06185 216594009600 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594009601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594009602 S-adenosylmethionine binding site [chemical binding]; other site 216594009603 Domain of unknown function (DUF385); Region: DUF385; cl04387 216594009604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594009605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594009606 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594009607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594009608 active site 216594009609 ATP binding site [chemical binding]; other site 216594009610 substrate binding site [chemical binding]; other site 216594009611 activation loop (A-loop); other site 216594009612 Uncharacterized conserved protein [Function unknown]; Region: COG3391 216594009613 NHL repeat; Region: NHL; pfam01436 216594009614 NHL repeat; Region: NHL; pfam01436 216594009615 NHL repeat; Region: NHL; pfam01436 216594009616 NHL repeat; Region: NHL; pfam01436 216594009617 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594009618 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594009619 PE family; Region: PE; pfam00934 216594009620 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216594009621 PE family; Region: PE; pfam00934 216594009622 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594009623 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594009624 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594009625 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594009626 active site 216594009627 ATP binding site [chemical binding]; other site 216594009628 substrate binding site [chemical binding]; other site 216594009629 activation loop (A-loop); other site 216594009630 AAA ATPase domain; Region: AAA_16; pfam13191 216594009631 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 216594009632 FOG: WD40 repeat [General function prediction only]; Region: COG2319 216594009633 structural tetrad; other site 216594009634 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 216594009635 structural tetrad; other site 216594009636 FOG: WD40 repeat [General function prediction only]; Region: COG2319 216594009637 WD domain, G-beta repeat; Region: WD40; pfam00400 216594009638 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 216594009639 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594009640 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594009641 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 216594009642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594009643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594009644 4Fe-4S binding domain; Region: Fer4; pfam00037 216594009645 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 216594009646 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 216594009647 dimer interface [polypeptide binding]; other site 216594009648 PYR/PP interface [polypeptide binding]; other site 216594009649 TPP binding site [chemical binding]; other site 216594009650 substrate binding site [chemical binding]; other site 216594009651 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 216594009652 Domain of unknown function; Region: EKR; pfam10371 216594009653 4Fe-4S binding domain; Region: Fer4_6; pfam12837 216594009654 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216594009655 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 216594009656 TPP-binding site [chemical binding]; other site 216594009657 dimer interface [polypeptide binding]; other site 216594009658 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 216594009659 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216594009660 phosphate binding site [ion binding]; other site 216594009661 phosphoenolpyruvate synthase; Validated; Region: PRK06464 216594009662 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 216594009663 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216594009664 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216594009665 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 216594009666 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 216594009667 active site 216594009668 ADP/pyrophosphate binding site [chemical binding]; other site 216594009669 dimerization interface [polypeptide binding]; other site 216594009670 allosteric effector site; other site 216594009671 fructose-1,6-bisphosphate binding site; other site 216594009672 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594009673 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216594009674 active site 216594009675 metal binding site [ion binding]; metal-binding site 216594009676 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594009677 FAD binding domain; Region: FAD_binding_4; pfam01565 216594009678 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216594009679 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216594009680 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 216594009681 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216594009682 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216594009683 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 216594009684 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216594009685 Active Sites [active] 216594009686 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 216594009687 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 216594009688 putative active site [active] 216594009689 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 216594009690 putative active site [active] 216594009691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216594009692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216594009693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216594009694 dimerization interface [polypeptide binding]; other site 216594009695 ferredoxin-NADP+ reductase; Region: PLN02852 216594009696 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 216594009697 4Fe-4S binding domain; Region: Fer4; cl02805 216594009698 MURD88; Overlaps a CDS encoding conserved hypothetical protein 216594009699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594009700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594009701 PE family; Region: PE; pfam00934 216594009702 MURD89; Overlaps 4 genes encoding hypothetical proteins, a PE-PGRS and PE family protein 216594009703 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 216594009704 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594009705 putative acyl-acceptor binding pocket; other site 216594009706 PE family; Region: PE; pfam00934 216594009707 PE-PPE domain; Region: PE-PPE; pfam08237 216594009708 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 216594009709 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594009710 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594009711 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594009712 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 216594009713 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594009714 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594009715 MURD90; Putative insertion sequence 216594009716 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 216594009717 Winged helix-turn helix; Region: HTH_29; pfam13551 216594009718 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216594009719 Integrase core domain; Region: rve; pfam00665 216594009720 Integrase core domain; Region: rve_3; pfam13683 216594009721 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594009722 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594009723 active site 216594009724 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 216594009725 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216594009726 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 216594009727 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 216594009728 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 216594009729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594009730 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 216594009731 hypothetical protein; Provisional; Region: PRK06834 216594009732 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594009733 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 216594009734 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594009735 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 216594009736 MURD156; Overlaps a unique CDS 216594009737 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594009738 PPE family; Region: PPE; pfam00823 216594009739 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594009740 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594009741 PPE family; Region: PPE; pfam00823 216594009742 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594009743 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 216594009744 Soybean trypsin inhibitor (Kunitz) family of protease inhibitors. Inhibit proteases by binding with high affinity to their active sites. Trefoil fold, common to interleukins and fibroblast growth factors; Region: STI; cl11466 216594009745 Peptidase family M23; Region: Peptidase_M23; pfam01551 216594009746 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216594009747 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594009748 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594009749 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594009750 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 216594009751 active site 216594009752 metal binding site [ion binding]; metal-binding site 216594009753 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 216594009754 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 216594009755 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 216594009756 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 216594009757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594009758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594009759 homodimer interface [polypeptide binding]; other site 216594009760 catalytic residue [active] 216594009761 Predicted transcriptional regulators [Transcription]; Region: COG1695 216594009762 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216594009763 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 216594009764 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216594009765 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 216594009766 active site 216594009767 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594009768 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594009769 active site 216594009770 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594009771 FAD binding domain; Region: FAD_binding_4; pfam01565 216594009772 MURD91; Putative insertion sequence 216594009773 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594009774 PPE family; Region: PPE; pfam00823 216594009775 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594009776 PPE family; Region: PPE; pfam00823 216594009777 MURD92; function Unknown functions; amongst many CDS, this MURD contains some encoding a putative pyruvate deydrogenase locus and PPE and PE-PGRS family proteins 216594009778 PE family; Region: PE; pfam00934 216594009779 PE-PPE domain; Region: PE-PPE; pfam08237 216594009780 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594009781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594009782 NAD(P) binding site [chemical binding]; other site 216594009783 active site 216594009784 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 216594009785 putative hydrophobic ligand binding site [chemical binding]; other site 216594009786 protein interface [polypeptide binding]; other site 216594009787 gate; other site 216594009788 haloalkane dehalogenase; Provisional; Region: PRK00870 216594009789 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 216594009790 active site 216594009791 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 216594009792 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 216594009793 active site 216594009794 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216594009795 dimer interface [polypeptide binding]; other site 216594009796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 216594009797 Predicted kinase [General function prediction only]; Region: COG0645 216594009798 AAA domain; Region: AAA_17; pfam13207 216594009799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594009800 Ligand Binding Site [chemical binding]; other site 216594009801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594009802 Ligand Binding Site [chemical binding]; other site 216594009803 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594009804 Ligand Binding Site [chemical binding]; other site 216594009805 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594009806 Ligand Binding Site [chemical binding]; other site 216594009807 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216594009808 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216594009809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216594009810 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216594009811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216594009812 Histidine kinase; Region: HisKA_3; pfam07730 216594009813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594009814 ATP binding site [chemical binding]; other site 216594009815 Mg2+ binding site [ion binding]; other site 216594009816 G-X-G motif; other site 216594009817 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594009818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594009819 active site 216594009820 phosphorylation site [posttranslational modification] 216594009821 intermolecular recognition site; other site 216594009822 dimerization interface [polypeptide binding]; other site 216594009823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594009824 DNA binding residues [nucleotide binding] 216594009825 dimerization interface [polypeptide binding]; other site 216594009826 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594009827 Ligand Binding Site [chemical binding]; other site 216594009828 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 216594009829 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 216594009830 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 216594009831 putative substrate binding site [chemical binding]; other site 216594009832 putative ATP binding site [chemical binding]; other site 216594009833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216594009834 active site 216594009835 Erythromycin esterase; Region: Erythro_esteras; pfam05139 216594009836 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216594009837 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 216594009838 putative dimer interface [polypeptide binding]; other site 216594009839 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216594009840 dimer interface [polypeptide binding]; other site 216594009841 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216594009842 acetyl-CoA synthetase; Provisional; Region: PRK04319 216594009843 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 216594009844 active site 216594009845 acyl-activating enzyme (AAE) consensus motif; other site 216594009846 putative CoA binding site [chemical binding]; other site 216594009847 AMP binding site [chemical binding]; other site 216594009848 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 216594009849 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216594009850 tetramer interface [polypeptide binding]; other site 216594009851 TPP-binding site [chemical binding]; other site 216594009852 heterodimer interface [polypeptide binding]; other site 216594009853 phosphorylation loop region [posttranslational modification] 216594009854 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216594009855 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216594009856 alpha subunit interface [polypeptide binding]; other site 216594009857 TPP binding site [chemical binding]; other site 216594009858 heterodimer interface [polypeptide binding]; other site 216594009859 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216594009860 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 216594009861 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216594009862 E3 interaction surface; other site 216594009863 lipoyl attachment site [posttranslational modification]; other site 216594009864 e3 binding domain; Region: E3_binding; pfam02817 216594009865 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216594009866 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216594009867 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 216594009868 PE family; Region: PE; pfam00934 216594009869 Domain of unknown function DUF302; Region: DUF302; pfam03625 216594009870 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 216594009871 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 216594009872 nickel binding site [ion binding]; other site 216594009873 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 216594009874 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 216594009875 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 216594009876 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 216594009877 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 216594009878 FAD binding pocket [chemical binding]; other site 216594009879 FAD binding motif [chemical binding]; other site 216594009880 phosphate binding motif [ion binding]; other site 216594009881 beta-alpha-beta structure motif; other site 216594009882 NAD binding pocket [chemical binding]; other site 216594009883 Iron coordination center [ion binding]; other site 216594009884 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 216594009885 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216594009886 dimer interface [polypeptide binding]; other site 216594009887 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216594009888 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 216594009889 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594009890 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216594009891 Hemerythrin-like domain; Region: Hr-like; cd12108 216594009892 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 216594009893 dimer interface [polypeptide binding]; other site 216594009894 ligand binding site [chemical binding]; other site 216594009895 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594009896 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594009897 cyclase homology domain; Region: CHD; cd07302 216594009898 nucleotidyl binding site; other site 216594009899 metal binding site [ion binding]; metal-binding site 216594009900 dimer interface [polypeptide binding]; other site 216594009901 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216594009902 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216594009903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594009904 NAD(P) binding site [chemical binding]; other site 216594009905 active site 216594009906 enoyl-CoA hydratase; Provisional; Region: PRK09245 216594009907 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594009908 substrate binding site [chemical binding]; other site 216594009909 oxyanion hole (OAH) forming residues; other site 216594009910 trimer interface [polypeptide binding]; other site 216594009911 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594009912 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594009913 active site 216594009914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594009915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594009916 NAD(P) binding site [chemical binding]; other site 216594009917 active site 216594009918 short chain dehydrogenase; Provisional; Region: PRK06482 216594009919 classical (c) SDRs; Region: SDR_c; cd05233 216594009920 NAD(P) binding site [chemical binding]; other site 216594009921 active site 216594009922 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 216594009923 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 216594009924 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 216594009925 active site 216594009926 catalytic site [active] 216594009927 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 216594009928 Fatty acid desaturase; Region: FA_desaturase; pfam00487 216594009929 Di-iron ligands [ion binding]; other site 216594009930 Rubredoxin [Energy production and conversion]; Region: COG1773 216594009931 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 216594009932 iron binding site [ion binding]; other site 216594009933 Rubredoxin [Energy production and conversion]; Region: COG1773 216594009934 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 216594009935 iron binding site [ion binding]; other site 216594009936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594009937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594009938 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216594009939 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216594009940 active site 216594009941 catalytic tetrad [active] 216594009942 heat shock protein 90; Provisional; Region: PRK05218 216594009943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594009944 ATP binding site [chemical binding]; other site 216594009945 Mg2+ binding site [ion binding]; other site 216594009946 G-X-G motif; other site 216594009947 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594009948 cyclase homology domain; Region: CHD; cd07302 216594009949 nucleotidyl binding site; other site 216594009950 metal binding site [ion binding]; metal-binding site 216594009951 dimer interface [polypeptide binding]; other site 216594009952 Predicted ATPase [General function prediction only]; Region: COG3903 216594009953 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594009954 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 216594009955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594009956 putative substrate translocation pore; other site 216594009957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594009958 S-adenosylmethionine binding site [chemical binding]; other site 216594009959 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 216594009960 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594009961 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216594009962 MURD93; Contains two genes, one encoding a hypothetical dehydrogenase 216594009963 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216594009964 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216594009965 NAD(P) binding site [chemical binding]; other site 216594009966 glycerol-3-phosphate dehydrogenase; Region: PLN02464 216594009967 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 216594009968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594009969 S-adenosylmethionine binding site [chemical binding]; other site 216594009970 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594009971 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594009972 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 216594009973 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 216594009974 active site 216594009975 NTP binding site [chemical binding]; other site 216594009976 nucleic acid binding site [nucleotide binding]; other site 216594009977 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 216594009978 CAS motifs; other site 216594009979 active site 216594009980 MURD94; Overlaps two CDS encoding hypothetical membrane proteins 216594009981 Uncharacterized conserved protein [Function unknown]; Region: COG0398 216594009982 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 216594009983 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216594009984 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216594009985 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 216594009986 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 216594009987 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216594009988 metal ion-dependent adhesion site (MIDAS); other site 216594009989 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 216594009990 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 216594009991 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 216594009992 DNA binding site [nucleotide binding] 216594009993 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594009994 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594009995 phosphopeptide binding site; other site 216594009996 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594009997 PPE family; Region: PPE; pfam00823 216594009998 MURD95; Overlaps a CDS encoding a serine threonine protein kinase (STPK) the N-term of which resemble PknK from MTB 216594009999 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594010000 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594010001 active site 216594010002 ATP binding site [chemical binding]; other site 216594010003 substrate binding site [chemical binding]; other site 216594010004 activation loop (A-loop); other site 216594010005 Predicted ATPase [General function prediction only]; Region: COG3903 216594010006 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 216594010007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594010008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594010009 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 216594010010 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 216594010011 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216594010012 PE family; Region: PE; pfam00934 216594010013 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 216594010014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216594010015 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216594010016 Dienelactone hydrolase family; Region: DLH; pfam01738 216594010017 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216594010018 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 216594010019 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 216594010020 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216594010021 NAD(P) binding site [chemical binding]; other site 216594010022 catalytic residues [active] 216594010023 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 216594010024 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 216594010025 AsnC family; Region: AsnC_trans_reg; pfam01037 216594010026 hypothetical protein; Provisional; Region: PRK06541 216594010027 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594010028 inhibitor-cofactor binding pocket; inhibition site 216594010029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594010030 catalytic residue [active] 216594010031 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594010032 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594010033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594010034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594010035 short chain dehydrogenase; Provisional; Region: PRK06179 216594010036 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216594010037 NADP binding site [chemical binding]; other site 216594010038 active site 216594010039 steroid binding site; other site 216594010040 Domain of unknown function (DUF385); Region: DUF385; cl04387 216594010041 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 216594010042 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 216594010043 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216594010044 NADP binding site [chemical binding]; other site 216594010045 dimer interface [polypeptide binding]; other site 216594010046 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 216594010047 Amidase; Region: Amidase; pfam01425 216594010048 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216594010049 Phosphoesterase family; Region: Phosphoesterase; pfam04185 216594010050 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594010051 MURD96; Contains CDS encoding a PPE and two PE-PGRS family proteins, two Esx-like proteins as well as other putative membrane proteins 216594010052 PE family; Region: PE; pfam00934 216594010053 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 216594010054 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 216594010055 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 216594010056 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 216594010057 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594010058 PPE family; Region: PPE; pfam00823 216594010059 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 216594010060 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 216594010061 PE family; Region: PE; pfam00934 216594010062 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 216594010063 SnoaL-like domain; Region: SnoaL_3; pfam13474 216594010064 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 216594010065 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594010066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594010067 DNA binding site [nucleotide binding] 216594010068 active site 216594010069 Int/Topo IB signature motif; other site 216594010070 bacteriophage phiMmar10; MURD97; Putative prophage. Intergrated near a tRNA gene and contains CDS encoding an integrase, partioning proteins and restriction modification systems 216594010071 Recombinase; Region: Recombinase; pfam07508 216594010072 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 216594010073 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 216594010074 HIRAN domain; Region: HIRAN; cl07418 216594010075 AAA ATPase domain; Region: AAA_15; pfam13175 216594010076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594010077 Walker A/P-loop; other site 216594010078 ATP binding site [chemical binding]; other site 216594010079 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 216594010080 putative active site [active] 216594010081 putative metal-binding site [ion binding]; other site 216594010082 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 216594010083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594010084 AAA domain; Region: AAA_23; pfam13476 216594010085 Walker A/P-loop; other site 216594010086 ATP binding site [chemical binding]; other site 216594010087 Q-loop/lid; other site 216594010088 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 216594010089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594010090 ABC transporter signature motif; other site 216594010091 Walker B; other site 216594010092 D-loop; other site 216594010093 H-loop/switch region; other site 216594010094 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 216594010095 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216594010096 active site 216594010097 metal binding site [ion binding]; metal-binding site 216594010098 DNA binding site [nucleotide binding] 216594010099 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 216594010100 HerA helicase [Replication, recombination, and repair]; Region: COG0433 216594010101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 216594010102 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 216594010103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594010104 non-specific DNA binding site [nucleotide binding]; other site 216594010105 salt bridge; other site 216594010106 sequence-specific DNA binding site [nucleotide binding]; other site 216594010107 Domain of unknown function (DUF955); Region: DUF955; pfam06114 216594010108 TrwC relaxase; Region: TrwC; pfam08751 216594010109 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 216594010110 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 216594010111 AAA domain; Region: AAA_30; pfam13604 216594010112 Family description; Region: UvrD_C_2; pfam13538 216594010113 Helix-turn-helix domain; Region: HTH_17; pfam12728 216594010114 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 216594010115 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594010116 active site 216594010117 DNA binding site [nucleotide binding] 216594010118 Int/Topo IB signature motif; other site 216594010119 Transport protein; Region: actII; TIGR00833 216594010120 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 216594010121 putative dimer interface [polypeptide binding]; other site 216594010122 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594010123 ligand binding site [chemical binding]; other site 216594010124 Zn binding site [ion binding]; other site 216594010125 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 216594010126 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 216594010127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594010128 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 216594010129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594010130 motif II; other site 216594010131 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216594010132 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216594010133 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 216594010134 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 216594010135 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216594010136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594010137 dimer interface [polypeptide binding]; other site 216594010138 conserved gate region; other site 216594010139 putative PBP binding loops; other site 216594010140 ABC-ATPase subunit interface; other site 216594010141 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216594010142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594010143 dimer interface [polypeptide binding]; other site 216594010144 conserved gate region; other site 216594010145 putative PBP binding loops; other site 216594010146 ABC-ATPase subunit interface; other site 216594010147 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216594010148 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216594010149 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594010150 Ligand Binding Site [chemical binding]; other site 216594010151 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594010152 Ligand Binding Site [chemical binding]; other site 216594010153 amino acid transporter; Region: 2A0306; TIGR00909 216594010154 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 216594010155 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 216594010156 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216594010157 inhibitor-cofactor binding pocket; inhibition site 216594010158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594010159 catalytic residue [active] 216594010160 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 216594010161 Amidinotransferase; Region: Amidinotransf; pfam02274 216594010162 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 216594010163 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216594010164 putative DNA binding site [nucleotide binding]; other site 216594010165 putative Zn2+ binding site [ion binding]; other site 216594010166 AsnC family; Region: AsnC_trans_reg; pfam01037 216594010167 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 216594010168 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644 216594010169 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 216594010170 Walker A/P-loop; other site 216594010171 ATP binding site [chemical binding]; other site 216594010172 Q-loop/lid; other site 216594010173 ABC transporter signature motif; other site 216594010174 Walker B; other site 216594010175 D-loop; other site 216594010176 H-loop/switch region; other site 216594010177 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 216594010178 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 216594010179 Walker A/P-loop; other site 216594010180 ATP binding site [chemical binding]; other site 216594010181 Q-loop/lid; other site 216594010182 ABC transporter signature motif; other site 216594010183 Walker B; other site 216594010184 D-loop; other site 216594010185 H-loop/switch region; other site 216594010186 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216594010187 MarR family; Region: MarR; pfam01047 216594010188 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 216594010189 phosphopeptide binding site; other site 216594010190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594010191 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 216594010192 Walker A/P-loop; other site 216594010193 ATP binding site [chemical binding]; other site 216594010194 Q-loop/lid; other site 216594010195 ABC transporter signature motif; other site 216594010196 Walker B; other site 216594010197 D-loop; other site 216594010198 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216594010199 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 216594010200 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 216594010201 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 216594010202 CCC1-related family of proteins; Region: CCC1_like; cl00278 216594010203 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594010204 active site 216594010205 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 216594010206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594010207 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594010208 active site 216594010209 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594010210 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594010211 acyl-activating enzyme (AAE) consensus motif; other site 216594010212 AMP binding site [chemical binding]; other site 216594010213 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594010214 Condensation domain; Region: Condensation; pfam00668 216594010215 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594010216 Condensation domain; Region: Condensation; pfam00668 216594010217 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594010218 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594010219 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594010220 acyl-activating enzyme (AAE) consensus motif; other site 216594010221 AMP binding site [chemical binding]; other site 216594010222 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594010223 Condensation domain; Region: Condensation; pfam00668 216594010224 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594010225 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 216594010226 MURD98; Possible transport locus. This MURD encodes 3 CDS encoding membrane proteins, including NarK1 involved in nitrite export 216594010227 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 216594010228 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 216594010229 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594010230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594010231 S-adenosylmethionine binding site [chemical binding]; other site 216594010232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594010233 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 216594010234 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 216594010235 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 216594010236 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 216594010237 [4Fe-4S] binding site [ion binding]; other site 216594010238 molybdopterin cofactor binding site; other site 216594010239 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 216594010240 molybdopterin cofactor binding site; other site 216594010241 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 216594010242 Flavodoxin; Region: Flavodoxin_1; pfam00258 216594010243 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 216594010244 FAD binding pocket [chemical binding]; other site 216594010245 FAD binding motif [chemical binding]; other site 216594010246 catalytic residues [active] 216594010247 NAD binding pocket [chemical binding]; other site 216594010248 phosphate binding motif [ion binding]; other site 216594010249 beta-alpha-beta structure motif; other site 216594010250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594010251 dimerization interface [polypeptide binding]; other site 216594010252 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594010253 cyclase homology domain; Region: CHD; cd07302 216594010254 nucleotidyl binding site; other site 216594010255 metal binding site [ion binding]; metal-binding site 216594010256 dimer interface [polypeptide binding]; other site 216594010257 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594010258 PPE family; Region: PPE; pfam00823 216594010259 MURD99; Overlaps 2 CDS encoding a PPE family protein and a hypothetical membrane protein 216594010260 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594010261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594010262 putative substrate translocation pore; other site 216594010263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594010264 malate dehydrogenase; Provisional; Region: PRK13529 216594010265 Malic enzyme, N-terminal domain; Region: malic; pfam00390 216594010266 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 216594010267 NAD(P) binding pocket [chemical binding]; other site 216594010268 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216594010269 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216594010270 dimer interface [polypeptide binding]; other site 216594010271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594010272 catalytic residue [active] 216594010273 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 216594010274 trimer interface [polypeptide binding]; other site 216594010275 active site 216594010276 substrate binding site [chemical binding]; other site 216594010277 CoA binding site [chemical binding]; other site 216594010278 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216594010279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216594010280 catalytic residues [active] 216594010281 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 216594010282 DNA primase; Validated; Region: dnaG; PRK05667 216594010283 CHC2 zinc finger; Region: zf-CHC2; cl17510 216594010284 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 216594010285 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 216594010286 active site 216594010287 metal binding site [ion binding]; metal-binding site 216594010288 interdomain interaction site; other site 216594010289 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 216594010290 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 216594010291 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 216594010292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216594010293 Zn2+ binding site [ion binding]; other site 216594010294 Mg2+ binding site [ion binding]; other site 216594010295 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 216594010296 Repair protein; Region: Repair_PSII; pfam04536 216594010297 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 216594010298 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 216594010299 MURD100; Contains CDS encoding 4 PPE family proteins and 2 phospholipase C proteins and 2 pairs of Esx-like proteins 216594010300 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216594010301 Phosphoesterase family; Region: Phosphoesterase; pfam04185 216594010302 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216594010303 Phosphoesterase family; Region: Phosphoesterase; pfam04185 216594010304 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 216594010305 Proteins of 100 residues with WXG; Region: WXG100; cl02005 216594010306 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 216594010307 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594010308 PPE family; Region: PPE; pfam00823 216594010309 Proteins of 100 residues with WXG; Region: WXG100; cl02005 216594010310 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 216594010311 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594010312 PPE family; Region: PPE; pfam00823 216594010313 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594010314 PPE family; Region: PPE; pfam00823 216594010315 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594010316 PPE family; Region: PPE; pfam00823 216594010317 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594010318 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594010319 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594010320 PPE family; Region: PPE; pfam00823 216594010321 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594010322 PPE family; Region: PPE; pfam00823 216594010323 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594010324 glycyl-tRNA synthetase; Provisional; Region: PRK04173 216594010325 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216594010326 motif 1; other site 216594010327 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 216594010328 active site 216594010329 motif 2; other site 216594010330 motif 3; other site 216594010331 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 216594010332 anticodon binding site; other site 216594010333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594010334 dimerization interface [polypeptide binding]; other site 216594010335 putative DNA binding site [nucleotide binding]; other site 216594010336 putative Zn2+ binding site [ion binding]; other site 216594010337 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216594010338 metal binding site 2 [ion binding]; metal-binding site 216594010339 putative DNA binding helix; other site 216594010340 metal binding site 1 [ion binding]; metal-binding site 216594010341 dimer interface [polypeptide binding]; other site 216594010342 structural Zn2+ binding site [ion binding]; other site 216594010343 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 216594010344 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 216594010345 catalytic residue [active] 216594010346 putative FPP diphosphate binding site; other site 216594010347 putative FPP binding hydrophobic cleft; other site 216594010348 dimer interface [polypeptide binding]; other site 216594010349 putative IPP diphosphate binding site; other site 216594010350 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 216594010351 Recombination protein O N terminal; Region: RecO_N; pfam11967 216594010352 Recombination protein O C terminal; Region: RecO_C; pfam02565 216594010353 amidase; Provisional; Region: PRK06061 216594010354 Amidase; Region: Amidase; pfam01425 216594010355 GTPase Era; Reviewed; Region: era; PRK00089 216594010356 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 216594010357 G1 box; other site 216594010358 GTP/Mg2+ binding site [chemical binding]; other site 216594010359 Switch I region; other site 216594010360 G2 box; other site 216594010361 Switch II region; other site 216594010362 G3 box; other site 216594010363 G4 box; other site 216594010364 G5 box; other site 216594010365 KH domain; Region: KH_2; pfam07650 216594010366 Domain of unknown function DUF21; Region: DUF21; pfam01595 216594010367 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216594010368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216594010369 Transporter associated domain; Region: CorC_HlyC; smart01091 216594010370 metal-binding heat shock protein; Provisional; Region: PRK00016 216594010371 K homology RNA-binding domain; Region: KH; smart00322 216594010372 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 216594010373 PhoH-like protein; Region: PhoH; pfam02562 216594010374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594010375 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 216594010376 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594010377 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594010378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594010379 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594010380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 216594010381 RNA methyltransferase, RsmE family; Region: TIGR00046 216594010382 chaperone protein DnaJ; Provisional; Region: PRK14278 216594010383 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216594010384 HSP70 interaction site [polypeptide binding]; other site 216594010385 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216594010386 Zn binding sites [ion binding]; other site 216594010387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 216594010388 dimer interface [polypeptide binding]; other site 216594010389 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 216594010390 HTH domain; Region: HTH_11; cl17392 216594010391 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 216594010392 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216594010393 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216594010394 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 216594010395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594010396 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 216594010397 Condensation domain; Region: Condensation; pfam00668 216594010398 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594010399 Nonribosomal peptide synthase; Region: NRPS; pfam08415 216594010400 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 216594010401 acyl-activating enzyme (AAE) consensus motif; other site 216594010402 AMP binding site [chemical binding]; other site 216594010403 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594010404 Condensation domain; Region: Condensation; pfam00668 216594010405 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594010406 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594010407 acyl-activating enzyme (AAE) consensus motif; other site 216594010408 AMP binding site [chemical binding]; other site 216594010409 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594010410 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216594010411 Condensation domain; Region: Condensation; pfam00668 216594010412 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594010413 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594010414 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594010415 acyl-activating enzyme (AAE) consensus motif; other site 216594010416 AMP binding site [chemical binding]; other site 216594010417 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594010418 Condensation domain; Region: Condensation; pfam00668 216594010419 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594010420 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594010421 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594010422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 216594010423 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 216594010424 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 216594010425 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594010426 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 216594010427 active site 216594010428 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594010429 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594010430 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 216594010431 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594010432 NADP binding site [chemical binding]; other site 216594010433 active site 216594010434 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594010435 MbtH-like protein; Region: MbtH; pfam03621 216594010436 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 216594010437 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 216594010438 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 216594010439 acyl-activating enzyme (AAE) consensus motif; other site 216594010440 active site 216594010441 AMP binding site [chemical binding]; other site 216594010442 substrate binding site [chemical binding]; other site 216594010443 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 216594010444 short chain dehydrogenase; Provisional; Region: PRK07832 216594010445 classical (c) SDRs; Region: SDR_c; cd05233 216594010446 NAD(P) binding site [chemical binding]; other site 216594010447 active site 216594010448 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 216594010449 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594010450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594010451 MURD101 216594010452 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 216594010453 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216594010454 DNA binding residues [nucleotide binding] 216594010455 putative dimer interface [polypeptide binding]; other site 216594010456 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 216594010457 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 216594010458 homodimer interface [polypeptide binding]; other site 216594010459 putative substrate binding pocket [chemical binding]; other site 216594010460 diiron center [ion binding]; other site 216594010461 salicylate synthase MbtI; Reviewed; Region: PRK07912 216594010462 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216594010463 Predicted permease [General function prediction only]; Region: COG3329 216594010464 coproporphyrinogen III oxidase; Validated; Region: PRK05628 216594010465 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 216594010466 active site 216594010467 HemN C-terminal domain; Region: HemN_C; pfam06969 216594010468 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 216594010469 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216594010470 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216594010471 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 216594010472 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216594010473 Active Sites [active] 216594010474 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 216594010475 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 216594010476 putative active site [active] 216594010477 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 216594010478 putative active site [active] 216594010479 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 216594010480 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216594010481 Predicted membrane protein [Function unknown]; Region: COG1297 216594010482 putative oligopeptide transporter, OPT family; Region: TIGR00733 216594010483 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 216594010484 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 216594010485 Walker A/P-loop; other site 216594010486 ATP binding site [chemical binding]; other site 216594010487 Q-loop/lid; other site 216594010488 ABC transporter signature motif; other site 216594010489 Walker B; other site 216594010490 D-loop; other site 216594010491 H-loop/switch region; other site 216594010492 TOBE domain; Region: TOBE; pfam03459 216594010493 sulfate transport protein; Provisional; Region: cysT; CHL00187 216594010494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594010495 dimer interface [polypeptide binding]; other site 216594010496 conserved gate region; other site 216594010497 putative PBP binding loops; other site 216594010498 ABC-ATPase subunit interface; other site 216594010499 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216594010500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594010501 dimer interface [polypeptide binding]; other site 216594010502 conserved gate region; other site 216594010503 putative PBP binding loops; other site 216594010504 ABC-ATPase subunit interface; other site 216594010505 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216594010506 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 216594010507 hypothetical protein; Provisional; Region: PRK06185 216594010508 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594010509 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 216594010510 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 216594010511 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594010512 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594010513 GTP-binding protein LepA; Provisional; Region: PRK05433 216594010514 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 216594010515 G1 box; other site 216594010516 putative GEF interaction site [polypeptide binding]; other site 216594010517 GTP/Mg2+ binding site [chemical binding]; other site 216594010518 Switch I region; other site 216594010519 G2 box; other site 216594010520 G3 box; other site 216594010521 Switch II region; other site 216594010522 G4 box; other site 216594010523 G5 box; other site 216594010524 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 216594010525 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 216594010526 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 216594010527 PemK-like protein; Region: PemK; pfam02452 216594010528 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 216594010529 FOG: CBS domain [General function prediction only]; Region: COG0517 216594010530 ribonuclease Z; Reviewed; Region: PRK00055 216594010531 PE family; Region: PE; pfam00934 216594010532 PE family; Region: PE; pfam00934 216594010533 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216594010534 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216594010535 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216594010536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 216594010537 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 216594010538 Uncharacterized conserved protein [Function unknown]; Region: COG2308 216594010539 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 216594010540 hypothetical protein; Reviewed; Region: PRK07914 216594010541 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 216594010542 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 216594010543 Competence protein; Region: Competence; cl00471 216594010544 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 216594010545 Helix-hairpin-helix motif; Region: HHH; pfam00633 216594010546 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 216594010547 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594010548 active site 216594010549 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 216594010550 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594010551 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594010552 active site 216594010553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594010554 hypothetical protein; Provisional; Region: PRK01346 216594010555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594010556 Coenzyme A binding pocket [chemical binding]; other site 216594010557 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 216594010558 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 216594010559 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 216594010560 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594010561 EDD domain protein, DegV family; Region: DegV; TIGR00762 216594010562 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 216594010563 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 216594010564 active site 216594010565 catalytic triad [active] 216594010566 oxyanion hole [active] 216594010567 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594010568 catalytic core [active] 216594010569 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 216594010570 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 216594010571 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 216594010572 active site 216594010573 (T/H)XGH motif; other site 216594010574 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594010575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594010576 S-adenosylmethionine binding site [chemical binding]; other site 216594010577 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 216594010578 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216594010579 metal ion-dependent adhesion site (MIDAS); other site 216594010580 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216594010581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594010582 Walker A motif; other site 216594010583 ATP binding site [chemical binding]; other site 216594010584 Walker B motif; other site 216594010585 arginine finger; other site 216594010586 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 216594010587 putative catalytic cysteine [active] 216594010588 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216594010589 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216594010590 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594010591 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594010592 ligand binding site [chemical binding]; other site 216594010593 flexible hinge region; other site 216594010594 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594010595 dimerization interface [polypeptide binding]; other site 216594010596 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 216594010597 cyclase homology domain; Region: CHD; cd07302 216594010598 nucleotidyl binding site; other site 216594010599 metal binding site [ion binding]; metal-binding site 216594010600 dimer interface [polypeptide binding]; other site 216594010601 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216594010602 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216594010603 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594010604 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594010605 ligand binding site [chemical binding]; other site 216594010606 flexible hinge region; other site 216594010607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594010608 dimerization interface [polypeptide binding]; other site 216594010609 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 216594010610 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 216594010611 cyclase homology domain; Region: CHD; cd07302 216594010612 nucleotidyl binding site; other site 216594010613 metal binding site [ion binding]; metal-binding site 216594010614 dimer interface [polypeptide binding]; other site 216594010615 PE family; Region: PE; pfam00934 216594010616 NAD synthetase; Reviewed; Region: nadE; PRK02628 216594010617 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 216594010618 multimer interface [polypeptide binding]; other site 216594010619 active site 216594010620 catalytic triad [active] 216594010621 protein interface 1 [polypeptide binding]; other site 216594010622 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 216594010623 homodimer interface [polypeptide binding]; other site 216594010624 NAD binding pocket [chemical binding]; other site 216594010625 ATP binding pocket [chemical binding]; other site 216594010626 Mg binding site [ion binding]; other site 216594010627 active-site loop [active] 216594010628 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 216594010629 NAD+ binding site [chemical binding]; other site 216594010630 substrate binding site [chemical binding]; other site 216594010631 Zn binding site [ion binding]; other site 216594010632 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594010633 Cytochrome P450; Region: p450; cl12078 216594010634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594010635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594010636 PE family; Region: PE; pfam00934 216594010637 gamma-glutamyl kinase; Provisional; Region: PRK05429 216594010638 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 216594010639 nucleotide binding site [chemical binding]; other site 216594010640 homotetrameric interface [polypeptide binding]; other site 216594010641 putative phosphate binding site [ion binding]; other site 216594010642 putative allosteric binding site; other site 216594010643 PUA domain; Region: PUA; pfam01472 216594010644 GTPase CgtA; Reviewed; Region: obgE; PRK12296 216594010645 GTP1/OBG; Region: GTP1_OBG; pfam01018 216594010646 Obg GTPase; Region: Obg; cd01898 216594010647 G1 box; other site 216594010648 GTP/Mg2+ binding site [chemical binding]; other site 216594010649 Switch I region; other site 216594010650 G2 box; other site 216594010651 G3 box; other site 216594010652 Switch II region; other site 216594010653 G4 box; other site 216594010654 G5 box; other site 216594010655 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 216594010656 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 216594010657 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 216594010658 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 216594010659 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 216594010660 homodimer interface [polypeptide binding]; other site 216594010661 oligonucleotide binding site [chemical binding]; other site 216594010662 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 216594010663 active site 216594010664 multimer interface [polypeptide binding]; other site 216594010665 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 216594010666 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 216594010667 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216594010668 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 216594010669 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216594010670 active site 216594010671 HIGH motif; other site 216594010672 nucleotide binding site [chemical binding]; other site 216594010673 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216594010674 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 216594010675 active site 216594010676 KMSKS motif; other site 216594010677 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 216594010678 tRNA binding surface [nucleotide binding]; other site 216594010679 anticodon binding site; other site 216594010680 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 216594010681 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 216594010682 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 216594010683 dimerization interface [polypeptide binding]; other site 216594010684 mannose binding site [chemical binding]; other site 216594010685 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216594010686 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 216594010687 Uncharacterized conserved protein [Function unknown]; Region: COG3268 216594010688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594010689 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 216594010690 MURD102; Large 64 kbp deletion of a secondary metabolite locus 216594010691 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594010692 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 216594010693 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594010694 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594010695 acyl-activating enzyme (AAE) consensus motif; other site 216594010696 AMP binding site [chemical binding]; other site 216594010697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594010698 S-adenosylmethionine binding site [chemical binding]; other site 216594010699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594010700 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594010701 Condensation domain; Region: Condensation; pfam00668 216594010702 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594010703 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594010704 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594010705 acyl-activating enzyme (AAE) consensus motif; other site 216594010706 AMP binding site [chemical binding]; other site 216594010707 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594010708 Condensation domain; Region: Condensation; pfam00668 216594010709 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216594010710 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 216594010711 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 216594010712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594010713 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216594010714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216594010715 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216594010716 HTH-like domain; Region: HTH_21; pfam13276 216594010717 Integrase core domain; Region: rve; pfam00665 216594010718 Integrase core domain; Region: rve_3; pfam13683 216594010719 Transposase; Region: HTH_Tnp_1; pfam01527 216594010720 Transposase; Region: HTH_Tnp_1; pfam01527 216594010721 HTH-like domain; Region: HTH_21; pfam13276 216594010722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216594010723 Integrase core domain; Region: rve; pfam00665 216594010724 Integrase core domain; Region: rve_3; pfam13683 216594010725 Isochorismatase family; Region: Isochorismatase; pfam00857 216594010726 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216594010727 catalytic triad [active] 216594010728 conserved cis-peptide bond; other site 216594010729 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216594010730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216594010731 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216594010732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216594010733 Transposase; Region: HTH_Tnp_1; cl17663 216594010734 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 216594010735 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216594010736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594010737 dimerization interface [polypeptide binding]; other site 216594010738 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594010739 cyclase homology domain; Region: CHD; cd07302 216594010740 nucleotidyl binding site; other site 216594010741 metal binding site [ion binding]; metal-binding site 216594010742 dimer interface [polypeptide binding]; other site 216594010743 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594010744 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594010745 active site 216594010746 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594010747 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594010748 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594010749 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594010750 putative NADP binding site [chemical binding]; other site 216594010751 active site 216594010752 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594010753 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594010754 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594010755 active site 216594010756 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594010757 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594010758 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594010759 putative NADP binding site [chemical binding]; other site 216594010760 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594010761 active site 216594010762 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594010763 Erythronolide synthase docking; Region: Docking; pfam08990 216594010764 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594010765 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594010766 active site 216594010767 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594010768 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594010769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594010770 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 216594010771 Enoylreductase; Region: PKS_ER; smart00829 216594010772 NAD(P) binding site [chemical binding]; other site 216594010773 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594010774 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594010775 putative NADP binding site [chemical binding]; other site 216594010776 active site 216594010777 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594010778 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594010779 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 216594010780 active site 216594010781 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594010782 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594010783 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 216594010784 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594010785 NADP binding site [chemical binding]; other site 216594010786 active site 216594010787 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594010788 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594010789 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594010790 active site 216594010791 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594010792 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594010793 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594010794 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594010795 putative NADP binding site [chemical binding]; other site 216594010796 active site 216594010797 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594010798 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 216594010799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594010800 active site 216594010801 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594010802 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 216594010803 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 216594010804 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 216594010805 putative NADP binding site [chemical binding]; other site 216594010806 active site 216594010807 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594010808 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 216594010809 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 216594010810 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 216594010811 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 216594010812 GTP binding site; other site 216594010813 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 216594010814 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 216594010815 TPP-binding site [chemical binding]; other site 216594010816 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 216594010817 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 216594010818 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 216594010819 dimer interface [polypeptide binding]; other site 216594010820 PYR/PP interface [polypeptide binding]; other site 216594010821 TPP binding site [chemical binding]; other site 216594010822 substrate binding site [chemical binding]; other site 216594010823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216594010824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594010825 putative substrate translocation pore; other site 216594010826 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 216594010827 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 216594010828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594010829 Walker A motif; other site 216594010830 ATP binding site [chemical binding]; other site 216594010831 Walker B motif; other site 216594010832 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 216594010833 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 216594010834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594010835 putative substrate translocation pore; other site 216594010836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594010837 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 216594010838 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216594010839 oligomer interface [polypeptide binding]; other site 216594010840 active site residues [active] 216594010841 Clp protease; Region: CLP_protease; pfam00574 216594010842 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216594010843 oligomer interface [polypeptide binding]; other site 216594010844 active site residues [active] 216594010845 trigger factor; Provisional; Region: tig; PRK01490 216594010846 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216594010847 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 216594010848 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594010849 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594010850 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 216594010851 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 216594010852 putative DNA binding site [nucleotide binding]; other site 216594010853 catalytic residue [active] 216594010854 putative H2TH interface [polypeptide binding]; other site 216594010855 putative catalytic residues [active] 216594010856 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 216594010857 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216594010858 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 216594010859 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216594010860 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216594010861 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 216594010862 catalytic residues [active] 216594010863 PE family; Region: PE; pfam00934 216594010864 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 216594010865 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 216594010866 Zn binding site [ion binding]; other site 216594010867 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 216594010868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594010869 active site 216594010870 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 216594010871 apolar tunnel; other site 216594010872 heme binding site [chemical binding]; other site 216594010873 dimerization interface [polypeptide binding]; other site 216594010874 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 216594010875 active site 216594010876 catalytic site [active] 216594010877 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216594010878 Phosphoesterase family; Region: Phosphoesterase; pfam04185 216594010879 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216594010880 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594010881 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 216594010882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594010883 putative substrate translocation pore; other site 216594010884 hypothetical protein; Provisional; Region: PRK07877 216594010885 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 216594010886 ATP binding site [chemical binding]; other site 216594010887 substrate interface [chemical binding]; other site 216594010888 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216594010889 active site 216594010890 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 216594010891 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 216594010892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216594010893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216594010894 ABC transporter; Region: ABC_tran_2; pfam12848 216594010895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216594010896 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216594010897 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216594010898 dimer interface [polypeptide binding]; other site 216594010899 ssDNA binding site [nucleotide binding]; other site 216594010900 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216594010901 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 216594010902 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 216594010903 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 216594010904 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 216594010905 putative acyl-acceptor binding pocket; other site 216594010906 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216594010907 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 216594010908 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594010909 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216594010910 putative acyl-acceptor binding pocket; other site 216594010911 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594010912 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594010913 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594010914 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216594010915 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594010916 Cutinase; Region: Cutinase; pfam01083 216594010917 cobyric acid synthase; Provisional; Region: PRK00784 216594010918 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 216594010919 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 216594010920 catalytic triad [active] 216594010921 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594010922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216594010923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594010924 S-adenosylmethionine binding site [chemical binding]; other site 216594010925 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 216594010926 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216594010927 E3 interaction surface; other site 216594010928 lipoyl attachment site [posttranslational modification]; other site 216594010929 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216594010930 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216594010931 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216594010932 alpha subunit interface [polypeptide binding]; other site 216594010933 TPP binding site [chemical binding]; other site 216594010934 heterodimer interface [polypeptide binding]; other site 216594010935 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216594010936 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 216594010937 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216594010938 tetramer interface [polypeptide binding]; other site 216594010939 TPP-binding site [chemical binding]; other site 216594010940 heterodimer interface [polypeptide binding]; other site 216594010941 phosphorylation loop region [posttranslational modification] 216594010942 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 216594010943 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 216594010944 putative active site [active] 216594010945 putative catalytic site [active] 216594010946 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594010947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594010948 active site 216594010949 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 216594010950 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216594010951 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216594010952 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 216594010953 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216594010954 carboxyltransferase (CT) interaction site; other site 216594010955 biotinylation site [posttranslational modification]; other site 216594010956 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 216594010957 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216594010958 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216594010959 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 216594010960 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 216594010961 AMP-binding domain protein; Validated; Region: PRK08315 216594010962 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594010963 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 216594010964 acyl-activating enzyme (AAE) consensus motif; other site 216594010965 acyl-activating enzyme (AAE) consensus motif; other site 216594010966 putative AMP binding site [chemical binding]; other site 216594010967 putative active site [active] 216594010968 putative CoA binding site [chemical binding]; other site 216594010969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594010970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594010971 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 216594010972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594010973 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216594010974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594010975 NAD(P) binding site [chemical binding]; other site 216594010976 active site 216594010977 MURD103; Putative insertion sequence 216594010978 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 216594010979 Winged helix-turn helix; Region: HTH_29; pfam13551 216594010980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216594010981 Integrase core domain; Region: rve; pfam00665 216594010982 Integrase core domain; Region: rve_3; pfam13683 216594010983 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 216594010984 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 216594010985 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 216594010986 catalytic site [active] 216594010987 putative active site [active] 216594010988 putative substrate binding site [chemical binding]; other site 216594010989 dimer interface [polypeptide binding]; other site 216594010990 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 216594010991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594010992 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594010993 Permease; Region: Permease; pfam02405 216594010994 Permease; Region: Permease; pfam02405 216594010995 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 216594010996 mce related protein; Region: MCE; pfam02470 216594010997 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594010998 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594010999 mce related protein; Region: MCE; pfam02470 216594011000 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011001 mce related protein; Region: MCE; pfam02470 216594011002 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011003 mce related protein; Region: MCE; pfam02470 216594011004 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011005 mce related protein; Region: MCE; pfam02470 216594011006 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011007 mce related protein; Region: MCE; pfam02470 216594011008 Mannan-binding protein; Region: MVL; pfam12151 216594011009 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 216594011010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216594011011 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 216594011012 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216594011013 bacteriophage phiMmar02; MURD104; Putative prophage. Contains many CDS encoding proteins with predicted functions in phage replication. Inserted near a tRNA gene 216594011014 PE family; Region: PE; pfam00934 216594011015 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 216594011016 active site 216594011017 Phage-related protein [Function unknown]; Region: COG5412 216594011018 Phage-related protein [Function unknown]; Region: COG5412 216594011019 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 216594011020 Interdomain contacts; other site 216594011021 Cytokine receptor motif; other site 216594011022 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 216594011023 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 216594011024 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 216594011025 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 216594011026 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 216594011027 HNH endonuclease; Region: HNH_3; pfam13392 216594011028 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216594011029 Transcription factor WhiB; Region: Whib; pfam02467 216594011030 NUMOD4 motif; Region: NUMOD4; pfam07463 216594011031 HNH endonuclease; Region: HNH_3; pfam13392 216594011032 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 216594011033 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 216594011034 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 216594011035 cofactor binding site; other site 216594011036 DNA binding site [nucleotide binding] 216594011037 substrate interaction site [chemical binding]; other site 216594011038 DNA polymerase III subunit beta; Validated; Region: PRK07761 216594011039 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 216594011040 putative DNA binding surface [nucleotide binding]; other site 216594011041 dimer interface [polypeptide binding]; other site 216594011042 beta-clamp/translesion DNA polymerase binding surface; other site 216594011043 beta-clamp/clamp loader binding surface; other site 216594011044 RecT family; Region: RecT; cl04285 216594011045 HNH endonuclease; Region: HNH_3; pfam13392 216594011046 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 216594011047 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594011048 Helix-turn-helix domain; Region: HTH_17; cl17695 216594011049 BRO family, N-terminal domain; Region: Bro-N; smart01040 216594011050 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 216594011051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594011052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216594011053 salt bridge; other site 216594011054 non-specific DNA binding site [nucleotide binding]; other site 216594011055 sequence-specific DNA binding site [nucleotide binding]; other site 216594011056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216594011057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216594011058 salt bridge; other site 216594011059 non-specific DNA binding site [nucleotide binding]; other site 216594011060 sequence-specific DNA binding site [nucleotide binding]; other site 216594011061 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594011062 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 216594011063 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594011064 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 216594011065 active site 216594011066 Int/Topo IB signature motif; other site 216594011067 DNA binding site [nucleotide binding] 216594011068 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 216594011069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594011070 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 216594011071 putative acyl-acceptor binding pocket; other site 216594011072 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 216594011073 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 216594011074 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 216594011075 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216594011076 catalytic triad [active] 216594011077 hypothetical protein; Provisional; Region: PRK07907 216594011078 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 216594011079 active site 216594011080 metal binding site [ion binding]; metal-binding site 216594011081 dimer interface [polypeptide binding]; other site 216594011082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216594011083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594011084 ATP binding site [chemical binding]; other site 216594011085 Mg2+ binding site [ion binding]; other site 216594011086 G-X-G motif; other site 216594011087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594011088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594011089 active site 216594011090 phosphorylation site [posttranslational modification] 216594011091 intermolecular recognition site; other site 216594011092 dimerization interface [polypeptide binding]; other site 216594011093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594011094 DNA binding residues [nucleotide binding] 216594011095 dimerization interface [polypeptide binding]; other site 216594011096 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 216594011097 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 216594011098 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 216594011099 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216594011100 phosphate binding site [ion binding]; other site 216594011101 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 216594011102 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 216594011103 putative active site [active] 216594011104 putative catalytic site [active] 216594011105 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 216594011106 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594011107 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 216594011108 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 216594011109 putative NAD(P) binding site [chemical binding]; other site 216594011110 active site 216594011111 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 216594011112 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 216594011113 active site 216594011114 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 216594011115 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594011116 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216594011117 [2Fe-2S] cluster binding site [ion binding]; other site 216594011118 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 216594011119 putative alpha subunit interface [polypeptide binding]; other site 216594011120 putative active site [active] 216594011121 putative substrate binding site [chemical binding]; other site 216594011122 Fe binding site [ion binding]; other site 216594011123 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 216594011124 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594011125 NAD binding site [chemical binding]; other site 216594011126 catalytic residues [active] 216594011127 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 216594011128 putative active site [active] 216594011129 putative catalytic site [active] 216594011130 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216594011131 active site 2 [active] 216594011132 active site 1 [active] 216594011133 SnoaL-like domain; Region: SnoaL_4; pfam13577 216594011134 SnoaL-like domain; Region: SnoaL_3; pfam13474 216594011135 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594011136 Cytochrome P450; Region: p450; cl12078 216594011137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594011138 putative substrate translocation pore; other site 216594011139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216594011140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594011141 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594011142 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216594011143 [2Fe-2S] cluster binding site [ion binding]; other site 216594011144 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216594011145 hydrophobic ligand binding site; other site 216594011146 MURD105; Contains a single gene encoding a putative NRP - metabolite unknown 216594011147 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216594011148 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216594011149 acyl-activating enzyme (AAE) consensus motif; other site 216594011150 AMP binding site [chemical binding]; other site 216594011151 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594011152 thioester reductase domain; Region: Thioester-redct; TIGR01746 216594011153 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 216594011154 putative NAD(P) binding site [chemical binding]; other site 216594011155 active site 216594011156 putative substrate binding site [chemical binding]; other site 216594011157 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 216594011158 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 216594011159 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594011160 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594011161 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594011162 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594011163 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216594011164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594011165 DNA-binding site [nucleotide binding]; DNA binding site 216594011166 FCD domain; Region: FCD; pfam07729 216594011167 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594011168 Cytochrome P450; Region: p450; cl12078 216594011169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594011170 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216594011171 putative substrate translocation pore; other site 216594011172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594011173 putative substrate translocation pore; other site 216594011174 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 216594011175 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594011176 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594011177 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011178 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594011179 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011180 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011181 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011182 active site 216594011183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011185 active site 216594011186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011187 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594011188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594011189 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 216594011190 putative AMP binding site [chemical binding]; other site 216594011191 putative active site [active] 216594011192 acyl-activating enzyme (AAE) consensus motif; other site 216594011193 acyl-activating enzyme (AAE) consensus motif; other site 216594011194 putative CoA binding site [chemical binding]; other site 216594011195 PE family; Region: PE; pfam00934 216594011196 PE-PPE domain; Region: PE-PPE; pfam08237 216594011197 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 216594011198 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 216594011199 putative sugar binding sites [chemical binding]; other site 216594011200 Q-X-W motif; other site 216594011201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594011202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594011203 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594011204 CoenzymeA binding site [chemical binding]; other site 216594011205 subunit interaction site [polypeptide binding]; other site 216594011206 PHB binding site; other site 216594011207 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594011208 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594011209 PPE family; Region: PPE; pfam00823 216594011210 PAS fold; Region: PAS_4; pfam08448 216594011211 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 216594011212 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 216594011213 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 216594011214 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216594011215 anti sigma factor interaction site; other site 216594011216 regulatory phosphorylation site [posttranslational modification]; other site 216594011217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011218 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011219 active site 216594011220 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011221 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594011222 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594011223 active site 216594011224 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 216594011225 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594011226 Cytochrome P450; Region: p450; cl12078 216594011227 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 216594011228 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 216594011229 NAD binding site [chemical binding]; other site 216594011230 catalytic Zn binding site [ion binding]; other site 216594011231 substrate binding site [chemical binding]; other site 216594011232 structural Zn binding site [ion binding]; other site 216594011233 short chain dehydrogenase; Provisional; Region: PRK06197 216594011234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594011235 NAD(P) binding site [chemical binding]; other site 216594011236 active site 216594011237 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594011238 Cytochrome P450; Region: p450; cl12078 216594011239 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216594011240 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216594011241 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216594011242 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 216594011243 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 216594011244 short chain dehydrogenase; Validated; Region: PRK06182 216594011245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594011246 NAD(P) binding site [chemical binding]; other site 216594011247 active site 216594011248 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 216594011249 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594011250 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216594011251 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594011252 CoenzymeA binding site [chemical binding]; other site 216594011253 subunit interaction site [polypeptide binding]; other site 216594011254 PHB binding site; other site 216594011255 acyl-CoA synthetase; Validated; Region: PRK07798 216594011256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594011257 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 216594011258 acyl-activating enzyme (AAE) consensus motif; other site 216594011259 acyl-activating enzyme (AAE) consensus motif; other site 216594011260 putative AMP binding site [chemical binding]; other site 216594011261 putative active site [active] 216594011262 putative CoA binding site [chemical binding]; other site 216594011263 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594011264 Cytochrome P450; Region: p450; cl12078 216594011265 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594011266 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594011267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011268 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011269 active site 216594011270 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 216594011271 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594011272 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011273 active site 216594011274 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594011275 acyl-CoA synthetase; Validated; Region: PRK07798 216594011276 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594011277 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 216594011278 acyl-activating enzyme (AAE) consensus motif; other site 216594011279 acyl-activating enzyme (AAE) consensus motif; other site 216594011280 putative AMP binding site [chemical binding]; other site 216594011281 putative active site [active] 216594011282 putative CoA binding site [chemical binding]; other site 216594011283 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594011284 enoyl-CoA hydratase; Provisional; Region: PRK06210 216594011285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594011286 substrate binding site [chemical binding]; other site 216594011287 oxyanion hole (OAH) forming residues; other site 216594011288 trimer interface [polypeptide binding]; other site 216594011289 tetracycline repressor protein TetR; Provisional; Region: PRK13756 216594011290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594011291 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 216594011292 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594011293 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594011294 substrate binding site [chemical binding]; other site 216594011295 oxyanion hole (OAH) forming residues; other site 216594011296 trimer interface [polypeptide binding]; other site 216594011297 enoyl-CoA hydratase; Provisional; Region: PRK06688 216594011298 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594011299 substrate binding site [chemical binding]; other site 216594011300 oxyanion hole (OAH) forming residues; other site 216594011301 trimer interface [polypeptide binding]; other site 216594011302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594011303 enoyl-CoA hydratase; Provisional; Region: PRK06494 216594011304 substrate binding site [chemical binding]; other site 216594011305 oxyanion hole (OAH) forming residues; other site 216594011306 trimer interface [polypeptide binding]; other site 216594011307 enoyl-CoA hydratase; Provisional; Region: PRK05980 216594011308 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594011309 substrate binding site [chemical binding]; other site 216594011310 oxyanion hole (OAH) forming residues; other site 216594011311 trimer interface [polypeptide binding]; other site 216594011312 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594011313 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594011314 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594011315 acyl-activating enzyme (AAE) consensus motif; other site 216594011316 acyl-activating enzyme (AAE) consensus motif; other site 216594011317 AMP binding site [chemical binding]; other site 216594011318 active site 216594011319 CoA binding site [chemical binding]; other site 216594011320 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594011321 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594011322 acyl-activating enzyme (AAE) consensus motif; other site 216594011323 AMP binding site [chemical binding]; other site 216594011324 active site 216594011325 CoA binding site [chemical binding]; other site 216594011326 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216594011327 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594011328 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594011329 acyl-activating enzyme (AAE) consensus motif; other site 216594011330 acyl-activating enzyme (AAE) consensus motif; other site 216594011331 AMP binding site [chemical binding]; other site 216594011332 active site 216594011333 CoA binding site [chemical binding]; other site 216594011334 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216594011335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594011336 DNA-binding site [nucleotide binding]; DNA binding site 216594011337 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216594011338 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011339 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011340 active site 216594011341 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 216594011342 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594011343 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 216594011344 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594011345 dimer interface [polypeptide binding]; other site 216594011346 active site 216594011347 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594011348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594011349 NAD(P) binding site [chemical binding]; other site 216594011350 active site 216594011351 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011352 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011353 active site 216594011354 Phosphotransferase enzyme family; Region: APH; pfam01636 216594011355 Ecdysteroid kinase; Region: EcKinase; cl17738 216594011356 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216594011357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594011358 Walker A/P-loop; other site 216594011359 ATP binding site [chemical binding]; other site 216594011360 Q-loop/lid; other site 216594011361 ABC transporter signature motif; other site 216594011362 Walker B; other site 216594011363 D-loop; other site 216594011364 H-loop/switch region; other site 216594011365 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 216594011366 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 216594011367 FAD binding pocket [chemical binding]; other site 216594011368 FAD binding motif [chemical binding]; other site 216594011369 phosphate binding motif [ion binding]; other site 216594011370 NAD binding pocket [chemical binding]; other site 216594011371 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216594011372 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 216594011373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594011374 Walker A/P-loop; other site 216594011375 ATP binding site [chemical binding]; other site 216594011376 Q-loop/lid; other site 216594011377 ABC transporter signature motif; other site 216594011378 Walker B; other site 216594011379 D-loop; other site 216594011380 H-loop/switch region; other site 216594011381 Glucitol operon activator protein (GutM); Region: GutM; cl01890 216594011382 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 216594011383 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 216594011384 active site 216594011385 dimerization interface [polypeptide binding]; other site 216594011386 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 216594011387 ribonuclease PH; Reviewed; Region: rph; PRK00173 216594011388 Ribonuclease PH; Region: RNase_PH_bact; cd11362 216594011389 hexamer interface [polypeptide binding]; other site 216594011390 active site 216594011391 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 216594011392 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 216594011393 TPP-binding site [chemical binding]; other site 216594011394 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 216594011395 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216594011396 dimerization interface [polypeptide binding]; other site 216594011397 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216594011398 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 216594011399 putative DNA binding site [nucleotide binding]; other site 216594011400 putative Zn2+ binding site [ion binding]; other site 216594011401 AsnC family; Region: AsnC_trans_reg; pfam01037 216594011402 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 216594011403 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594011404 Permease; Region: Permease; pfam02405 216594011405 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594011406 Permease; Region: Permease; pfam02405 216594011407 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011408 mce related protein; Region: MCE; pfam02470 216594011409 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594011410 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011411 mce related protein; Region: MCE; pfam02470 216594011412 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011413 mce related protein; Region: MCE; pfam02470 216594011414 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011415 mce related protein; Region: MCE; pfam02470 216594011416 mce related protein; Region: MCE; pfam02470 216594011417 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594011418 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594011419 mce related protein; Region: MCE; pfam02470 216594011420 glutamate racemase; Provisional; Region: PRK00865 216594011421 Rhomboid family; Region: Rhomboid; pfam01694 216594011422 MURD106; function Unknown function. Contains 3 hypothetical proteins 216594011423 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 216594011424 MoaE interaction surface [polypeptide binding]; other site 216594011425 MoeB interaction surface [polypeptide binding]; other site 216594011426 thiocarboxylated glycine; other site 216594011427 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 216594011428 MPN+ (JAMM) motif; other site 216594011429 Zinc-binding site [ion binding]; other site 216594011430 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 216594011431 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 216594011432 cleavage site 216594011433 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 216594011434 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 216594011435 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 216594011436 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 216594011437 active site 216594011438 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 216594011439 DEAD/DEAH box helicase; Region: DEAD; pfam00270 216594011440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594011441 putative Mg++ binding site [ion binding]; other site 216594011442 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 216594011443 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 216594011444 putative homodimer interface [polypeptide binding]; other site 216594011445 putative active site pocket [active] 216594011446 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 216594011447 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 216594011448 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 216594011449 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216594011450 active site 216594011451 homodimer interface [polypeptide binding]; other site 216594011452 catalytic site [active] 216594011453 acceptor binding site [chemical binding]; other site 216594011454 glycogen branching enzyme; Provisional; Region: PRK05402 216594011455 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 216594011456 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 216594011457 active site 216594011458 catalytic site [active] 216594011459 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 216594011460 MURD107; Putative insertion sequence 216594011461 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 216594011462 Winged helix-turn helix; Region: HTH_29; pfam13551 216594011463 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216594011464 Integrase core domain; Region: rve; pfam00665 216594011465 Integrase core domain; Region: rve_3; pfam13683 216594011466 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 216594011467 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 216594011468 putative acyltransferase; Provisional; Region: PRK05790 216594011469 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594011470 dimer interface [polypeptide binding]; other site 216594011471 active site 216594011472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594011473 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 216594011474 dimer interface [polypeptide binding]; other site 216594011475 substrate binding site [chemical binding]; other site 216594011476 metal binding site [ion binding]; metal-binding site 216594011477 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 216594011478 hypothetical protein; Provisional; Region: PRK03298 216594011479 HAMP domain; Region: HAMP; pfam00672 216594011480 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594011481 cyclase homology domain; Region: CHD; cd07302 216594011482 nucleotidyl binding site; other site 216594011483 metal binding site [ion binding]; metal-binding site 216594011484 dimer interface [polypeptide binding]; other site 216594011485 MURD108; Overlaps a CDS encoding a putative adenylate cyclase 216594011486 HAMP domain; Region: HAMP; pfam00672 216594011487 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594011488 cyclase homology domain; Region: CHD; cd07302 216594011489 nucleotidyl binding site; other site 216594011490 metal binding site [ion binding]; metal-binding site 216594011491 dimer interface [polypeptide binding]; other site 216594011492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594011493 dimerization interface [polypeptide binding]; other site 216594011494 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594011495 cyclase homology domain; Region: CHD; cd07302 216594011496 nucleotidyl binding site; other site 216594011497 metal binding site [ion binding]; metal-binding site 216594011498 dimer interface [polypeptide binding]; other site 216594011499 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 216594011500 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 216594011501 AlkA N-terminal domain; Region: AlkA_N; pfam06029 216594011502 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 216594011503 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216594011504 minor groove reading motif; other site 216594011505 helix-hairpin-helix signature motif; other site 216594011506 substrate binding pocket [chemical binding]; other site 216594011507 active site 216594011508 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 216594011509 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 216594011510 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216594011511 DNA binding site [nucleotide binding] 216594011512 active site 216594011513 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 216594011514 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 216594011515 hinge; other site 216594011516 active site 216594011517 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 216594011518 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 216594011519 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 216594011520 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 216594011521 gamma subunit interface [polypeptide binding]; other site 216594011522 epsilon subunit interface [polypeptide binding]; other site 216594011523 LBP interface [polypeptide binding]; other site 216594011524 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 216594011525 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 216594011526 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 216594011527 alpha subunit interaction interface [polypeptide binding]; other site 216594011528 Walker A motif; other site 216594011529 ATP binding site [chemical binding]; other site 216594011530 Walker B motif; other site 216594011531 inhibitor binding site; inhibition site 216594011532 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216594011533 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 216594011534 core domain interface [polypeptide binding]; other site 216594011535 delta subunit interface [polypeptide binding]; other site 216594011536 epsilon subunit interface [polypeptide binding]; other site 216594011537 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 216594011538 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 216594011539 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 216594011540 beta subunit interaction interface [polypeptide binding]; other site 216594011541 Walker A motif; other site 216594011542 ATP binding site [chemical binding]; other site 216594011543 Walker B motif; other site 216594011544 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216594011545 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 216594011546 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 216594011547 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 216594011548 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 216594011549 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 216594011550 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 216594011551 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 216594011552 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 216594011553 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 216594011554 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 216594011555 Mg++ binding site [ion binding]; other site 216594011556 putative catalytic motif [active] 216594011557 substrate binding site [chemical binding]; other site 216594011558 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 216594011559 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 216594011560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594011561 S-adenosylmethionine binding site [chemical binding]; other site 216594011562 peptide chain release factor 1; Validated; Region: prfA; PRK00591 216594011563 This domain is found in peptide chain release factors; Region: PCRF; smart00937 216594011564 RF-1 domain; Region: RF-1; pfam00472 216594011565 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 216594011566 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 216594011567 transcription termination factor Rho; Provisional; Region: PRK12608 216594011568 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216594011569 RNA binding site [nucleotide binding]; other site 216594011570 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 216594011571 multimer interface [polypeptide binding]; other site 216594011572 Walker A motif; other site 216594011573 ATP binding site [chemical binding]; other site 216594011574 Walker B motif; other site 216594011575 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 216594011576 threonine synthase; Reviewed; Region: PRK06721 216594011577 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 216594011578 homodimer interface [polypeptide binding]; other site 216594011579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594011580 catalytic residue [active] 216594011581 homoserine dehydrogenase; Provisional; Region: PRK06349 216594011582 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 216594011583 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216594011584 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 216594011585 diaminopimelate decarboxylase; Region: lysA; TIGR01048 216594011586 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 216594011587 active site 216594011588 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216594011589 substrate binding site [chemical binding]; other site 216594011590 catalytic residues [active] 216594011591 dimer interface [polypeptide binding]; other site 216594011592 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 216594011593 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 216594011594 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 216594011595 active site 216594011596 HIGH motif; other site 216594011597 KMSK motif region; other site 216594011598 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 216594011599 tRNA binding surface [nucleotide binding]; other site 216594011600 anticodon binding site; other site 216594011601 MURD109; function Unknown function, three CDS encode a transposase and two proteins of unknown function. Possible insertion sequence 216594011602 Winged helix-turn helix; Region: HTH_29; pfam13551 216594011603 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216594011604 DNA-binding interface [nucleotide binding]; DNA binding site 216594011605 Homeodomain-like domain; Region: HTH_32; pfam13565 216594011606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216594011607 Integrase core domain; Region: rve; pfam00665 216594011608 Integrase core domain; Region: rve_3; pfam13683 216594011609 PE family; Region: PE; pfam00934 216594011610 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 216594011611 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 216594011612 putative catalytic cysteine [active] 216594011613 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 216594011614 active site 216594011615 NAD binding site [chemical binding]; other site 216594011616 metal binding site [ion binding]; metal-binding site 216594011617 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 216594011618 YCII-related domain; Region: YCII; cl00999 216594011619 haloalkane dehalogenase; Provisional; Region: PRK03592 216594011620 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 216594011621 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 216594011622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594011623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594011624 PE family; Region: PE; pfam00934 216594011625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216594011626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216594011627 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 216594011628 putative dimerization interface [polypeptide binding]; other site 216594011629 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 216594011630 EamA-like transporter family; Region: EamA; pfam00892 216594011631 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 216594011632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594011633 dimerization interface [polypeptide binding]; other site 216594011634 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594011635 cyclase homology domain; Region: CHD; cd07302 216594011636 nucleotidyl binding site; other site 216594011637 metal binding site [ion binding]; metal-binding site 216594011638 dimer interface [polypeptide binding]; other site 216594011639 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594011640 Predicted membrane protein [Function unknown]; Region: COG4325 216594011641 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 216594011642 MURD110; Function unknown but contains CDS encoding two hypothetical membrane proteins and a nudix hydrolase 216594011643 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 216594011644 dimer interface [polypeptide binding]; other site 216594011645 ADP-ribose binding site [chemical binding]; other site 216594011646 active site 216594011647 nudix motif; other site 216594011648 metal binding site [ion binding]; metal-binding site 216594011649 TrkA-N domain; Region: TrkA_N; pfam02254 216594011650 Ion channel; Region: Ion_trans_2; pfam07885 216594011651 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 216594011652 TrkA-N domain; Region: TrkA_N; pfam02254 216594011653 TrkA-C domain; Region: TrkA_C; pfam02080 216594011654 PE family; Region: PE; pfam00934 216594011655 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 216594011656 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 216594011657 putative dimer interface [polypeptide binding]; other site 216594011658 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594011659 ligand binding site [chemical binding]; other site 216594011660 Zn binding site [ion binding]; other site 216594011661 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 216594011662 metal binding site [ion binding]; metal-binding site 216594011663 Rrf2 family protein; Region: rrf2_super; TIGR00738 216594011664 Transcriptional regulator; Region: Rrf2; pfam02082 216594011665 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 216594011666 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 216594011667 CysD dimerization site [polypeptide binding]; other site 216594011668 G1 box; other site 216594011669 putative GEF interaction site [polypeptide binding]; other site 216594011670 GTP/Mg2+ binding site [chemical binding]; other site 216594011671 Switch I region; other site 216594011672 G2 box; other site 216594011673 G3 box; other site 216594011674 Switch II region; other site 216594011675 G4 box; other site 216594011676 G5 box; other site 216594011677 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 216594011678 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 216594011679 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 216594011680 ligand-binding site [chemical binding]; other site 216594011681 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 216594011682 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216594011683 Active Sites [active] 216594011684 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594011685 CoenzymeA binding site [chemical binding]; other site 216594011686 subunit interaction site [polypeptide binding]; other site 216594011687 PHB binding site; other site 216594011688 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 216594011689 active site clefts [active] 216594011690 zinc binding site [ion binding]; other site 216594011691 dimer interface [polypeptide binding]; other site 216594011692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216594011693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594011694 dimer interface [polypeptide binding]; other site 216594011695 conserved gate region; other site 216594011696 putative PBP binding loops; other site 216594011697 ABC-ATPase subunit interface; other site 216594011698 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216594011699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594011700 dimer interface [polypeptide binding]; other site 216594011701 conserved gate region; other site 216594011702 putative PBP binding loops; other site 216594011703 ABC-ATPase subunit interface; other site 216594011704 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 216594011705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216594011706 Walker A/P-loop; other site 216594011707 ATP binding site [chemical binding]; other site 216594011708 Q-loop/lid; other site 216594011709 ABC transporter signature motif; other site 216594011710 Walker B; other site 216594011711 D-loop; other site 216594011712 H-loop/switch region; other site 216594011713 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216594011714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216594011715 Walker A/P-loop; other site 216594011716 ATP binding site [chemical binding]; other site 216594011717 Q-loop/lid; other site 216594011718 ABC transporter signature motif; other site 216594011719 Walker B; other site 216594011720 D-loop; other site 216594011721 H-loop/switch region; other site 216594011722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216594011723 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 216594011724 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216594011725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594011726 choline dehydrogenase; Validated; Region: PRK02106 216594011727 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594011728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594011729 Walker A/P-loop; other site 216594011730 ATP binding site [chemical binding]; other site 216594011731 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 216594011732 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 216594011733 active site 216594011734 metal binding site [ion binding]; metal-binding site 216594011735 DNA binding site [nucleotide binding] 216594011736 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594011737 catalytic core [active] 216594011738 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 216594011739 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 216594011740 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216594011741 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216594011742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594011743 Walker A/P-loop; other site 216594011744 ATP binding site [chemical binding]; other site 216594011745 Q-loop/lid; other site 216594011746 ABC transporter signature motif; other site 216594011747 Walker B; other site 216594011748 D-loop; other site 216594011749 H-loop/switch region; other site 216594011750 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216594011751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216594011752 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 216594011753 Walker A/P-loop; other site 216594011754 ATP binding site [chemical binding]; other site 216594011755 Q-loop/lid; other site 216594011756 ABC transporter signature motif; other site 216594011757 Walker B; other site 216594011758 D-loop; other site 216594011759 H-loop/switch region; other site 216594011760 PE family; Region: PE; pfam00934 216594011761 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594011762 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594011763 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 216594011764 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 216594011765 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 216594011766 putative active site [active] 216594011767 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 216594011768 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 216594011769 DNA binding site [nucleotide binding] 216594011770 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594011771 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594011772 phosphopeptide binding site; other site 216594011773 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594011774 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594011775 active site 216594011776 ATP binding site [chemical binding]; other site 216594011777 substrate binding site [chemical binding]; other site 216594011778 activation loop (A-loop); other site 216594011779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216594011780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216594011781 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 216594011782 putative dimerization interface [polypeptide binding]; other site 216594011783 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 216594011784 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 216594011785 putative active site [active] 216594011786 putative catalytic site [active] 216594011787 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 216594011788 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 216594011789 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 216594011790 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594011791 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594011792 active site 216594011793 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 216594011794 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 216594011795 putative active site [active] 216594011796 catalytic site [active] 216594011797 putative metal binding site [ion binding]; other site 216594011798 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 216594011799 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 216594011800 putative DNA binding site [nucleotide binding]; other site 216594011801 putative Zn2+ binding site [ion binding]; other site 216594011802 AsnC family; Region: AsnC_trans_reg; pfam01037 216594011803 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 216594011804 dimer interface [polypeptide binding]; other site 216594011805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594011806 metal binding site [ion binding]; metal-binding site 216594011807 MURD111; function Unknown function but overlaps a potential signal transduction locus as this regions includes a CDS encoding STPK 216594011808 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 216594011809 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594011810 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594011811 active site 216594011812 ATP binding site [chemical binding]; other site 216594011813 substrate binding site [chemical binding]; other site 216594011814 activation loop (A-loop); other site 216594011815 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594011816 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594011817 phosphopeptide binding site; other site 216594011818 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216594011819 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216594011820 phosphopeptide binding site; other site 216594011821 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 216594011822 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216594011823 Walker A/P-loop; other site 216594011824 ATP binding site [chemical binding]; other site 216594011825 Q-loop/lid; other site 216594011826 ABC transporter signature motif; other site 216594011827 Walker B; other site 216594011828 D-loop; other site 216594011829 H-loop/switch region; other site 216594011830 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 216594011831 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594011832 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594011833 active site 216594011834 ATP binding site [chemical binding]; other site 216594011835 substrate binding site [chemical binding]; other site 216594011836 activation loop (A-loop); other site 216594011837 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594011838 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594011839 cyclase homology domain; Region: CHD; cd07302 216594011840 nucleotidyl binding site; other site 216594011841 metal binding site [ion binding]; metal-binding site 216594011842 dimer interface [polypeptide binding]; other site 216594011843 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594011844 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594011845 active site 216594011846 ATP binding site [chemical binding]; other site 216594011847 substrate binding site [chemical binding]; other site 216594011848 activation loop (A-loop); other site 216594011849 amidase; Provisional; Region: PRK12470 216594011850 Amidase; Region: Amidase; cl11426 216594011851 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 216594011852 HIT family signature motif; other site 216594011853 catalytic residue [active] 216594011854 Domain of unknown function (DUF385); Region: DUF385; pfam04075 216594011855 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 216594011856 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594011857 hypothetical protein; Validated; Region: PRK05868 216594011858 hypothetical protein; Provisional; Region: PRK07236 216594011859 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594011860 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 216594011861 Fe-S cluster binding site [ion binding]; other site 216594011862 DNA binding site [nucleotide binding] 216594011863 active site 216594011864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594011865 H+ Antiporter protein; Region: 2A0121; TIGR00900 216594011866 putative substrate translocation pore; other site 216594011867 FAD binding domain; Region: FAD_binding_4; pfam01565 216594011868 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 216594011869 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594011870 Cytochrome P450; Region: p450; cl12078 216594011871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594011872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594011873 PE family; Region: PE; pfam00934 216594011874 MURD112; Within a CDS encoding a PE-PGRS family protein 216594011875 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594011876 PPE family; Region: PPE; pfam00823 216594011877 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216594011878 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 216594011879 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216594011880 ATP binding site [chemical binding]; other site 216594011881 Mg++ binding site [ion binding]; other site 216594011882 motif III; other site 216594011883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594011884 nucleotide binding region [chemical binding]; other site 216594011885 ATP-binding site [chemical binding]; other site 216594011886 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 216594011887 putative RNA binding site [nucleotide binding]; other site 216594011888 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 216594011889 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 216594011890 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 216594011891 RNase_H superfamily; Region: RNase_H_2; pfam13482 216594011892 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 216594011893 Part of AAA domain; Region: AAA_19; pfam13245 216594011894 AAA domain; Region: AAA_12; pfam13087 216594011895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594011896 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594011897 putative substrate translocation pore; other site 216594011898 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 216594011899 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216594011900 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 216594011901 TPP-binding site [chemical binding]; other site 216594011902 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 216594011903 dimer interface [polypeptide binding]; other site 216594011904 PYR/PP interface [polypeptide binding]; other site 216594011905 TPP binding site [chemical binding]; other site 216594011906 classical (c) SDRs; Region: SDR_c; cd05233 216594011907 short chain dehydrogenase; Provisional; Region: PRK08267 216594011908 NAD(P) binding site [chemical binding]; other site 216594011909 active site 216594011910 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216594011911 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 216594011912 Malic enzyme, N-terminal domain; Region: malic; pfam00390 216594011913 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 216594011914 putative NAD(P) binding site [chemical binding]; other site 216594011915 malate dehydrogenase; Provisional; Region: PRK05442 216594011916 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 216594011917 NAD(P) binding site [chemical binding]; other site 216594011918 dimer interface [polypeptide binding]; other site 216594011919 malate binding site [chemical binding]; other site 216594011920 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216594011921 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 216594011922 oligomer interface [polypeptide binding]; other site 216594011923 metal binding site [ion binding]; metal-binding site 216594011924 metal binding site [ion binding]; metal-binding site 216594011925 putative Cl binding site [ion binding]; other site 216594011926 basic sphincter; other site 216594011927 hydrophobic gate; other site 216594011928 periplasmic entrance; other site 216594011929 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216594011930 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 216594011931 active site 216594011932 dimer interface [polypeptide binding]; other site 216594011933 non-prolyl cis peptide bond; other site 216594011934 insertion regions; other site 216594011935 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 216594011936 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 216594011937 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216594011938 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216594011939 Walker A/P-loop; other site 216594011940 ATP binding site [chemical binding]; other site 216594011941 Q-loop/lid; other site 216594011942 ABC transporter signature motif; other site 216594011943 Walker B; other site 216594011944 D-loop; other site 216594011945 H-loop/switch region; other site 216594011946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216594011947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594011948 dimer interface [polypeptide binding]; other site 216594011949 conserved gate region; other site 216594011950 ABC-ATPase subunit interface; other site 216594011951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594011952 dimer interface [polypeptide binding]; other site 216594011953 conserved gate region; other site 216594011954 putative PBP binding loops; other site 216594011955 ABC-ATPase subunit interface; other site 216594011956 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216594011957 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216594011958 MURD113; function Unknown but region contains CDS encoding hypothetical membrane proteins and a lipoprotein 216594011959 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 216594011960 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 216594011961 MgtE intracellular N domain; Region: MgtE_N; smart00924 216594011962 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 216594011963 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 216594011964 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 216594011965 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216594011966 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216594011967 catalytic residue [active] 216594011968 Domain of unknown function DUF59; Region: DUF59; cl00941 216594011969 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 216594011970 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 216594011971 sec-independent translocase; Provisional; Region: PRK03100 216594011972 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 216594011973 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216594011974 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216594011975 protein binding site [polypeptide binding]; other site 216594011976 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 216594011977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594011978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216594011979 DNA binding residues [nucleotide binding] 216594011980 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 216594011981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594011982 S-adenosylmethionine binding site [chemical binding]; other site 216594011983 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594011984 PPE family; Region: PPE; pfam00823 216594011985 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594011986 MURD114; Overlaps the N-term of a CDS encoding a PPE family protein. Other CDS encode a transcriptional regulator and putative transporter 216594011987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594011988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594011989 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216594011990 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216594011991 Walker A/P-loop; other site 216594011992 ATP binding site [chemical binding]; other site 216594011993 Q-loop/lid; other site 216594011994 ABC transporter signature motif; other site 216594011995 Walker B; other site 216594011996 D-loop; other site 216594011997 H-loop/switch region; other site 216594011998 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 216594011999 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 216594012000 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 216594012001 PE family; Region: PE; pfam00934 216594012002 MURD115; Contains two CDS encoding PE-PGRS family proteins 216594012003 PE family; Region: PE; pfam00934 216594012004 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 216594012005 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 216594012006 ligand binding site; other site 216594012007 oligomer interface; other site 216594012008 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 216594012009 dimer interface [polypeptide binding]; other site 216594012010 N-terminal domain interface [polypeptide binding]; other site 216594012011 sulfate 1 binding site; other site 216594012012 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 216594012013 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216594012014 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 216594012015 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 216594012016 DivIVA domain; Region: DivI1A_domain; TIGR03544 216594012017 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 216594012018 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216594012019 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 216594012020 dihydropteroate synthase; Region: DHPS; TIGR01496 216594012021 substrate binding pocket [chemical binding]; other site 216594012022 dimer interface [polypeptide binding]; other site 216594012023 inhibitor binding site; inhibition site 216594012024 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 216594012025 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 216594012026 acyl-activating enzyme (AAE) consensus motif; other site 216594012027 putative AMP binding site [chemical binding]; other site 216594012028 putative active site [active] 216594012029 putative CoA binding site [chemical binding]; other site 216594012030 TIGR00730 family protein; Region: TIGR00730 216594012031 AAA ATPase domain; Region: AAA_16; pfam13191 216594012032 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 216594012033 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 216594012034 metal binding site [ion binding]; metal-binding site 216594012035 putative dimer interface [polypeptide binding]; other site 216594012036 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 216594012037 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 216594012038 putative trimer interface [polypeptide binding]; other site 216594012039 putative CoA binding site [chemical binding]; other site 216594012040 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594012041 putative DNA binding site [nucleotide binding]; other site 216594012042 putative Zn2+ binding site [ion binding]; other site 216594012043 metabolite-proton symporter; Region: 2A0106; TIGR00883 216594012044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594012045 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012046 PPE family; Region: PPE; pfam00823 216594012047 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594012048 PE family; Region: PE; pfam00934 216594012049 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594012050 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594012051 acyl-CoA synthetase; Validated; Region: PRK07787 216594012052 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594012053 acyl-activating enzyme (AAE) consensus motif; other site 216594012054 AMP binding site [chemical binding]; other site 216594012055 active site 216594012056 CoA binding site [chemical binding]; other site 216594012057 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594012058 PGAP1-like protein; Region: PGAP1; pfam07819 216594012059 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594012060 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 216594012061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594012062 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216594012063 NAD(P) binding site [chemical binding]; other site 216594012064 catalytic residues [active] 216594012065 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 216594012066 active site 216594012067 catalytic site [active] 216594012068 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 216594012069 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 216594012070 DUF35 OB-fold domain; Region: DUF35; pfam01796 216594012071 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 216594012072 putative active site [active] 216594012073 putative catalytic site [active] 216594012074 lipid-transfer protein; Provisional; Region: PRK07855 216594012075 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594012076 active site 216594012077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594012078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594012079 Proline dehydrogenase; Region: Pro_dh; cl03282 216594012080 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 216594012081 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 216594012082 Glutamate binding site [chemical binding]; other site 216594012083 NAD binding site [chemical binding]; other site 216594012084 catalytic residues [active] 216594012085 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594012086 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594012087 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 216594012088 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 216594012089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594012090 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 216594012091 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216594012092 active site 216594012093 MURD116; Contains three CDS that encode enzymes possibly involved in the sulfation of glycolipids 216594012094 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 216594012095 ligand-binding site [chemical binding]; other site 216594012096 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 216594012097 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 216594012098 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 216594012099 MURD117; Contains a single hypothetical membrane protein 216594012100 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 216594012101 ATP-sulfurylase; Region: ATPS; cd00517 216594012102 active site 216594012103 HXXH motif; other site 216594012104 flexible loop; other site 216594012105 MURD118; Overlaps two CDS encoding a nitrite export protein and PPE family protein 216594012106 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 216594012107 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012108 PPE family; Region: PPE; pfam00823 216594012109 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012110 PPE family; Region: PPE; pfam00823 216594012111 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594012112 MURD119; Overlaps three CDS including two PPE family proteins and a PE-PGRS family protein 216594012113 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012114 PPE family; Region: PPE; pfam00823 216594012115 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594012116 PE family; Region: PE; pfam00934 216594012117 hypothetical protein; Provisional; Region: PRK06834 216594012118 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594012119 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594012120 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 216594012121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594012122 ATP binding site [chemical binding]; other site 216594012123 putative Mg++ binding site [ion binding]; other site 216594012124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 216594012125 nucleotide binding region [chemical binding]; other site 216594012126 ATP-binding site [chemical binding]; other site 216594012127 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 216594012128 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594012129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594012130 homodimer interface [polypeptide binding]; other site 216594012131 catalytic residue [active] 216594012132 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 216594012133 4Fe-4S binding domain; Region: Fer4; pfam00037 216594012134 Predicted transcriptional regulators [Transcription]; Region: COG1695 216594012135 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216594012136 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 216594012137 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216594012138 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 216594012139 active site 216594012140 FMN binding site [chemical binding]; other site 216594012141 2,4-decadienoyl-CoA binding site; other site 216594012142 catalytic residue [active] 216594012143 4Fe-4S cluster binding site [ion binding]; other site 216594012144 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 216594012145 PE family; Region: PE; pfam00934 216594012146 Cellulose binding domain; Region: CBM_2; pfam00553 216594012147 Cellulose binding domain; Region: CBM_2; pfam00553 216594012148 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 216594012149 active site 216594012150 FO synthase; Reviewed; Region: fbiC; PRK09234 216594012151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594012152 FeS/SAM binding site; other site 216594012153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594012154 FeS/SAM binding site; other site 216594012155 PE family; Region: PE; pfam00934 216594012156 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 216594012157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594012158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594012159 PE family; Region: PE; pfam00934 216594012160 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 216594012161 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216594012162 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 216594012163 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 216594012164 G1 box; other site 216594012165 putative GEF interaction site [polypeptide binding]; other site 216594012166 GTP/Mg2+ binding site [chemical binding]; other site 216594012167 Switch I region; other site 216594012168 G2 box; other site 216594012169 G3 box; other site 216594012170 Switch II region; other site 216594012171 G4 box; other site 216594012172 G5 box; other site 216594012173 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 216594012174 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 216594012175 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 216594012176 active site 216594012177 8-oxo-dGMP binding site [chemical binding]; other site 216594012178 nudix motif; other site 216594012179 metal binding site [ion binding]; metal-binding site 216594012180 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 216594012181 aromatic arch; other site 216594012182 DCoH dimer interaction site [polypeptide binding]; other site 216594012183 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 216594012184 DCoH tetramer interaction site [polypeptide binding]; other site 216594012185 substrate binding site [chemical binding]; other site 216594012186 mannosyltransferase; Provisional; Region: pimE; PRK13375 216594012187 uncharacterized HhH-GPD family protein; Region: TIGR03252 216594012188 minor groove reading motif; other site 216594012189 helix-hairpin-helix signature motif; other site 216594012190 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 216594012191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 216594012192 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594012193 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 216594012194 Predicted transcriptional regulators [Transcription]; Region: COG1725 216594012195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594012196 DNA-binding site [nucleotide binding]; DNA binding site 216594012197 NAD-dependent deacetylase; Provisional; Region: PRK00481 216594012198 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 216594012199 NAD+ binding site [chemical binding]; other site 216594012200 substrate binding site [chemical binding]; other site 216594012201 Zn binding site [ion binding]; other site 216594012202 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594012203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012204 S-adenosylmethionine binding site [chemical binding]; other site 216594012205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594012206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594012207 WHG domain; Region: WHG; pfam13305 216594012208 MMPL family; Region: MMPL; pfam03176 216594012209 MMPL family; Region: MMPL; pfam03176 216594012210 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 216594012211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594012212 NAD(P) binding site [chemical binding]; other site 216594012213 active site 216594012214 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594012215 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594012216 enoyl-CoA hydratase; Provisional; Region: PRK06688 216594012217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594012218 substrate binding site [chemical binding]; other site 216594012219 oxyanion hole (OAH) forming residues; other site 216594012220 trimer interface [polypeptide binding]; other site 216594012221 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 216594012222 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216594012223 putative NAD(P) binding site [chemical binding]; other site 216594012224 putative active site [active] 216594012225 CAAX protease self-immunity; Region: Abi; pfam02517 216594012226 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216594012227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594012228 NAD(P) binding site [chemical binding]; other site 216594012229 active site 216594012230 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 216594012231 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 216594012232 malonyl-CoA binding site [chemical binding]; other site 216594012233 dimer interface [polypeptide binding]; other site 216594012234 active site 216594012235 product binding site; other site 216594012236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 216594012237 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 216594012238 PE family; Region: PE; pfam00934 216594012239 MURD120; Overlaps a single, large CDS encoding PE-PGRS family protein 216594012240 enoyl-CoA hydratase; Provisional; Region: PRK08252 216594012241 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594012242 substrate binding site [chemical binding]; other site 216594012243 oxyanion hole (OAH) forming residues; other site 216594012244 trimer interface [polypeptide binding]; other site 216594012245 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 216594012246 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594012247 dimer interface [polypeptide binding]; other site 216594012248 active site 216594012249 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012250 PPE family; Region: PPE; pfam00823 216594012251 PPE family; Region: PPE; pfam00823 216594012252 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012253 PE family; Region: PE; pfam00934 216594012254 PE-PPE domain; Region: PE-PPE; pfam08237 216594012255 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 216594012256 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 216594012257 NAD binding site [chemical binding]; other site 216594012258 catalytic residues [active] 216594012259 MURD121; Putative insertion sequence 216594012260 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216594012261 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012262 PPE family; Region: PPE; pfam00823 216594012263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594012264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594012265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594012266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594012267 short chain dehydrogenase; Provisional; Region: PRK12829 216594012268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594012269 NAD(P) binding site [chemical binding]; other site 216594012270 active site 216594012271 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 216594012272 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216594012273 NAD(P) binding site [chemical binding]; other site 216594012274 putative active site [active] 216594012275 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 216594012276 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 216594012277 THF binding site; other site 216594012278 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 216594012279 substrate binding site [chemical binding]; other site 216594012280 THF binding site; other site 216594012281 zinc-binding site [ion binding]; other site 216594012282 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 216594012283 Predicted membrane protein [Function unknown]; Region: COG2259 216594012284 pyruvate phosphate dikinase; Provisional; Region: PRK05878 216594012285 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 216594012286 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216594012287 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594012288 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594012289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594012290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594012291 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 216594012292 dimer interface [polypeptide binding]; other site 216594012293 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594012294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594012295 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216594012296 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 216594012297 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216594012298 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 216594012299 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 216594012300 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 216594012301 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594012302 cyclase homology domain; Region: CHD; cd07302 216594012303 nucleotidyl binding site; other site 216594012304 metal binding site [ion binding]; metal-binding site 216594012305 dimer interface [polypeptide binding]; other site 216594012306 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 216594012307 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216594012308 OsmC-like protein; Region: OsmC; pfam02566 216594012309 NlpC/P60 family; Region: NLPC_P60; cl17555 216594012310 MURD122; Overlaps two CDS encoding a hypothetical secreted protein and a PPE family protein 216594012311 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012312 PPE family; Region: PPE; pfam00823 216594012313 MURD123; function Unknown; contains a single hypothetical CDS 216594012314 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 216594012315 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 216594012316 GTP-binding protein YchF; Reviewed; Region: PRK09601 216594012317 YchF GTPase; Region: YchF; cd01900 216594012318 G1 box; other site 216594012319 GTP/Mg2+ binding site [chemical binding]; other site 216594012320 Switch I region; other site 216594012321 G2 box; other site 216594012322 Switch II region; other site 216594012323 G3 box; other site 216594012324 G4 box; other site 216594012325 G5 box; other site 216594012326 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 216594012327 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 216594012328 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 216594012329 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 216594012330 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 216594012331 generic binding surface II; other site 216594012332 generic binding surface I; other site 216594012333 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 216594012334 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 216594012335 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 216594012336 putative NAD(P) binding site [chemical binding]; other site 216594012337 active site 216594012338 putative substrate binding site [chemical binding]; other site 216594012339 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 216594012340 MURD124; Overlaps a CDS encoding a PE-PGRS family protein 216594012341 PE family; Region: PE; pfam00934 216594012342 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 216594012343 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216594012344 substrate binding pocket [chemical binding]; other site 216594012345 catalytic triad [active] 216594012346 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216594012347 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216594012348 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 216594012349 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 216594012350 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 216594012351 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 216594012352 putative active site [active] 216594012353 fumarate hydratase; Reviewed; Region: fumC; PRK00485 216594012354 Class II fumarases; Region: Fumarase_classII; cd01362 216594012355 active site 216594012356 tetramer interface [polypeptide binding]; other site 216594012357 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 216594012358 dimerization interface [polypeptide binding]; other site 216594012359 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594012360 cyclase homology domain; Region: CHD; cd07302 216594012361 nucleotidyl binding site; other site 216594012362 metal binding site [ion binding]; metal-binding site 216594012363 dimer interface [polypeptide binding]; other site 216594012364 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 216594012365 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 216594012366 NodB motif; other site 216594012367 active site 216594012368 catalytic site [active] 216594012369 metal binding site [ion binding]; metal-binding site 216594012370 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 216594012371 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 216594012372 putative active site [active] 216594012373 PhoH-like protein; Region: PhoH; pfam02562 216594012374 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 216594012375 dinuclear metal binding motif [ion binding]; other site 216594012376 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 216594012377 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 216594012378 dimer interface [polypeptide binding]; other site 216594012379 active site 216594012380 glycine-pyridoxal phosphate binding site [chemical binding]; other site 216594012381 folate binding site [chemical binding]; other site 216594012382 pantothenate kinase; Provisional; Region: PRK05439 216594012383 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 216594012384 ATP-binding site [chemical binding]; other site 216594012385 CoA-binding site [chemical binding]; other site 216594012386 Mg2+-binding site [ion binding]; other site 216594012387 PE family; Region: PE; pfam00934 216594012388 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 216594012389 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 216594012390 catalytic residue [active] 216594012391 putative FPP diphosphate binding site; other site 216594012392 putative FPP binding hydrophobic cleft; other site 216594012393 dimer interface [polypeptide binding]; other site 216594012394 putative IPP diphosphate binding site; other site 216594012395 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 216594012396 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 216594012397 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216594012398 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 216594012399 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 216594012400 catalytic residues [active] 216594012401 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 216594012402 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 216594012403 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 216594012404 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 216594012405 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216594012406 cystathionine gamma-synthase; Provisional; Region: PRK07811 216594012407 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216594012408 homodimer interface [polypeptide binding]; other site 216594012409 substrate-cofactor binding pocket; other site 216594012410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594012411 catalytic residue [active] 216594012412 RDD family; Region: RDD; pfam06271 216594012413 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 216594012414 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216594012415 dimer interface [polypeptide binding]; other site 216594012416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594012417 catalytic residue [active] 216594012418 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 216594012419 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 216594012420 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 216594012421 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 216594012422 active site 216594012423 catalytic triad [active] 216594012424 oxyanion hole [active] 216594012425 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 216594012426 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594012427 dimer interface [polypeptide binding]; other site 216594012428 active site 216594012429 Predicted membrane protein [Function unknown]; Region: COG4760 216594012430 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 216594012431 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594012432 substrate binding site [chemical binding]; other site 216594012433 oxyanion hole (OAH) forming residues; other site 216594012434 trimer interface [polypeptide binding]; other site 216594012435 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 216594012436 enoyl-CoA hydratase; Provisional; Region: PRK05862 216594012437 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594012438 substrate binding site [chemical binding]; other site 216594012439 oxyanion hole (OAH) forming residues; other site 216594012440 trimer interface [polypeptide binding]; other site 216594012441 Predicted membrane protein [Function unknown]; Region: COG4425 216594012442 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 216594012443 PE family; Region: PE; pfam00934 216594012444 MURD125; Contains two CDS encoding two large PE-PGRS family proteins 216594012445 PE family; Region: PE; pfam00934 216594012446 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 216594012447 active site residue [active] 216594012448 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 216594012449 hypothetical protein; Provisional; Region: PRK10279 216594012450 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 216594012451 active site 216594012452 nucleophile elbow; other site 216594012453 Patatin-like phospholipase; Region: Patatin; pfam01734 216594012454 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 216594012455 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 216594012456 putative active site [active] 216594012457 putative dimer interface [polypeptide binding]; other site 216594012458 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 216594012459 hydrophobic ligand binding site; other site 216594012460 PE family; Region: PE; pfam00934 216594012461 MURD126; Contains a single CDS encoding a PE-PGRS family protein 216594012462 Uncharacterized conserved protein [Function unknown]; Region: COG1262 216594012463 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 216594012464 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 216594012465 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 216594012466 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594012467 Sulfatase; Region: Sulfatase; pfam00884 216594012468 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 216594012469 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216594012470 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 216594012471 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 216594012472 dimer interface [polypeptide binding]; other site 216594012473 acyl-activating enzyme (AAE) consensus motif; other site 216594012474 putative active site [active] 216594012475 AMP binding site [chemical binding]; other site 216594012476 putative CoA binding site [chemical binding]; other site 216594012477 Uncharacterized conserved protein [Function unknown]; Region: COG3391 216594012478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 216594012479 MURD127; A large deletion harbouring CDS with a possible role in intermediary metabolism. Includes CDS encoding dehydrogenases, oxidoreductases, a P450 hydroxylase and an aminomethyltransferase - the latter being a component of the glycine cleavage system 216594012480 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 216594012481 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 216594012482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594012483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594012484 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 216594012485 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216594012486 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216594012487 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 216594012488 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216594012489 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 216594012490 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216594012491 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594012492 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216594012493 [2Fe-2S] cluster binding site [ion binding]; other site 216594012494 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 216594012495 putative alpha subunit interface [polypeptide binding]; other site 216594012496 putative active site [active] 216594012497 putative substrate binding site [chemical binding]; other site 216594012498 Fe binding site [ion binding]; other site 216594012499 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216594012500 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216594012501 Bacterial transcriptional regulator; Region: IclR; pfam01614 216594012502 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 216594012503 putative active site [active] 216594012504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012505 S-adenosylmethionine binding site [chemical binding]; other site 216594012506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216594012507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216594012508 choline dehydrogenase; Validated; Region: PRK02106 216594012509 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216594012510 haloalkane dehalogenase; Provisional; Region: PRK03204 216594012511 Transport protein; Region: actII; TIGR00833 216594012512 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594012513 Cytochrome P450; Region: p450; cl12078 216594012514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594012515 Coenzyme A binding pocket [chemical binding]; other site 216594012516 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 216594012517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594012518 dimerization interface [polypeptide binding]; other site 216594012519 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594012520 cyclase homology domain; Region: CHD; cd07302 216594012521 nucleotidyl binding site; other site 216594012522 metal binding site [ion binding]; metal-binding site 216594012523 dimer interface [polypeptide binding]; other site 216594012524 bacteriophage phiMmar03; MURD128; Putative prophage, insertion at leucine tRNA gene 216594012525 Protein of unknown function DUF262; Region: DUF262; pfam03235 216594012526 Uncharacterized conserved protein [Function unknown]; Region: COG1479 216594012527 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594012528 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 216594012529 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594012530 active site 216594012531 DNA binding site [nucleotide binding] 216594012532 Int/Topo IB signature motif; other site 216594012533 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216594012534 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216594012535 catalytic residues [active] 216594012536 catalytic nucleophile [active] 216594012537 Presynaptic Site I dimer interface [polypeptide binding]; other site 216594012538 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216594012539 Synaptic Flat tetramer interface [polypeptide binding]; other site 216594012540 Synaptic Site I dimer interface [polypeptide binding]; other site 216594012541 DNA binding site [nucleotide binding] 216594012542 Recombinase; Region: Recombinase; pfam07508 216594012543 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 216594012544 polymerase nucleotide-binding site; other site 216594012545 DNA-binding residues [nucleotide binding]; DNA binding site 216594012546 nucleotide binding site [chemical binding]; other site 216594012547 primase nucleotide-binding site [nucleotide binding]; other site 216594012548 AAA domain; Region: AAA_25; pfam13481 216594012549 PE family; Region: PE; pfam00934 216594012550 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594012551 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012552 PPE family; Region: PPE; pfam00823 216594012553 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 216594012554 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 216594012555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594012556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594012557 active site 216594012558 phosphorylation site [posttranslational modification] 216594012559 intermolecular recognition site; other site 216594012560 dimerization interface [polypeptide binding]; other site 216594012561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594012562 DNA binding site [nucleotide binding] 216594012563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216594012564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594012565 dimer interface [polypeptide binding]; other site 216594012566 phosphorylation site [posttranslational modification] 216594012567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594012568 ATP binding site [chemical binding]; other site 216594012569 Mg2+ binding site [ion binding]; other site 216594012570 G-X-G motif; other site 216594012571 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 216594012572 exopolyphosphatase; Region: exo_poly_only; TIGR03706 216594012573 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 216594012574 Uncharacterized conserved protein [Function unknown]; Region: COG1507 216594012575 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 216594012576 Septum formation initiator; Region: DivIC; pfam04977 216594012577 enolase; Provisional; Region: eno; PRK00077 216594012578 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 216594012579 dimer interface [polypeptide binding]; other site 216594012580 metal binding site [ion binding]; metal-binding site 216594012581 substrate binding pocket [chemical binding]; other site 216594012582 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 216594012583 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216594012584 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216594012585 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 216594012586 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 216594012587 homodimer interface [polypeptide binding]; other site 216594012588 metal binding site [ion binding]; metal-binding site 216594012589 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 216594012590 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 216594012591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594012592 ATP binding site [chemical binding]; other site 216594012593 putative Mg++ binding site [ion binding]; other site 216594012594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594012595 nucleotide binding region [chemical binding]; other site 216594012596 ATP-binding site [chemical binding]; other site 216594012597 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 216594012598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594012599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594012600 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 216594012601 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 216594012602 Substrate binding site; other site 216594012603 Mg++ binding site; other site 216594012604 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 216594012605 active site 216594012606 substrate binding site [chemical binding]; other site 216594012607 CoA binding site [chemical binding]; other site 216594012608 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 216594012609 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 216594012610 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216594012611 active site 216594012612 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 216594012613 ArsC family; Region: ArsC; pfam03960 216594012614 catalytic residues [active] 216594012615 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 216594012616 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 216594012617 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 216594012618 5S rRNA interface [nucleotide binding]; other site 216594012619 CTC domain interface [polypeptide binding]; other site 216594012620 L16 interface [polypeptide binding]; other site 216594012621 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 216594012622 putative active site [active] 216594012623 catalytic residue [active] 216594012624 Domain of unknown function DUF302; Region: DUF302; pfam03625 216594012625 Domain of unknown function DUF302; Region: DUF302; pfam03625 216594012626 PE family; Region: PE; pfam00934 216594012627 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 216594012628 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594012629 acyl-activating enzyme (AAE) consensus motif; other site 216594012630 active site 216594012631 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 216594012632 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 216594012633 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 216594012634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012635 S-adenosylmethionine binding site [chemical binding]; other site 216594012636 Domain of unknown function (DUF348); Region: DUF348; pfam03990 216594012637 Domain of unknown function (DUF348); Region: DUF348; pfam03990 216594012638 G5 domain; Region: G5; pfam07501 216594012639 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 216594012640 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216594012641 active site 216594012642 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 216594012643 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 216594012644 active site 216594012645 HIGH motif; other site 216594012646 KMSKS motif; other site 216594012647 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 216594012648 tRNA binding surface [nucleotide binding]; other site 216594012649 anticodon binding site; other site 216594012650 MURD129; Overlaps a methytransferase and P450 hydroxylase 216594012651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012652 S-adenosylmethionine binding site [chemical binding]; other site 216594012653 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594012654 Cytochrome P450; Region: p450; cl12078 216594012655 putative acyl transferase; Provisional; Region: PRK10191 216594012656 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 216594012657 trimer interface [polypeptide binding]; other site 216594012658 active site 216594012659 substrate binding site [chemical binding]; other site 216594012660 CoA binding site [chemical binding]; other site 216594012661 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 216594012662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594012663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594012664 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 216594012665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594012666 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216594012667 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 216594012668 chorismate binding enzyme; Region: Chorismate_bind; cl10555 216594012669 Predicted methyltransferases [General function prediction only]; Region: COG0313 216594012670 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 216594012671 putative SAM binding site [chemical binding]; other site 216594012672 putative homodimer interface [polypeptide binding]; other site 216594012673 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 216594012674 arginine deiminase; Provisional; Region: PRK01388 216594012675 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 216594012676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594012677 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594012678 ligand binding site [chemical binding]; other site 216594012679 flexible hinge region; other site 216594012680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216594012681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594012682 Coenzyme A binding pocket [chemical binding]; other site 216594012683 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594012684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012685 S-adenosylmethionine binding site [chemical binding]; other site 216594012686 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 216594012687 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012688 PPE family; Region: PPE; pfam00823 216594012689 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 216594012690 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 216594012691 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216594012692 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216594012693 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 216594012694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216594012695 active site 216594012696 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216594012697 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216594012698 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594012699 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216594012700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594012701 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594012702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012703 S-adenosylmethionine binding site [chemical binding]; other site 216594012704 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 216594012705 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216594012706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012707 S-adenosylmethionine binding site [chemical binding]; other site 216594012708 Methyltransferase domain; Region: Methyltransf_11; pfam08241 216594012709 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216594012710 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 216594012711 active site 216594012712 catalytic triad [active] 216594012713 dimer interface [polypeptide binding]; other site 216594012714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012715 S-adenosylmethionine binding site [chemical binding]; other site 216594012716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216594012717 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216594012718 O-Antigen ligase; Region: Wzy_C; pfam04932 216594012719 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 216594012720 Chain length determinant protein; Region: Wzz; pfam02706 216594012721 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 216594012722 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 216594012723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216594012724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216594012725 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 216594012726 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 216594012727 dimer interface [polypeptide binding]; other site 216594012728 putative functional site; other site 216594012729 putative MPT binding site; other site 216594012730 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 216594012731 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 216594012732 active site 216594012733 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 216594012734 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 216594012735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 216594012736 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 216594012737 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 216594012738 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 216594012739 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 216594012740 MPT binding site; other site 216594012741 trimer interface [polypeptide binding]; other site 216594012742 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 216594012743 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216594012744 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216594012745 protein binding site [polypeptide binding]; other site 216594012746 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216594012747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594012748 dimerization interface [polypeptide binding]; other site 216594012749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594012750 dimer interface [polypeptide binding]; other site 216594012751 phosphorylation site [posttranslational modification] 216594012752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594012753 ATP binding site [chemical binding]; other site 216594012754 Mg2+ binding site [ion binding]; other site 216594012755 G-X-G motif; other site 216594012756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594012757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594012758 active site 216594012759 phosphorylation site [posttranslational modification] 216594012760 intermolecular recognition site; other site 216594012761 dimerization interface [polypeptide binding]; other site 216594012762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594012763 DNA binding site [nucleotide binding] 216594012764 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 216594012765 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594012766 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594012767 active site 216594012768 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216594012769 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216594012770 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216594012771 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 216594012772 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216594012773 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216594012774 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216594012775 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216594012776 carboxyltransferase (CT) interaction site; other site 216594012777 biotinylation site [posttranslational modification]; other site 216594012778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594012779 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594012780 active site 216594012781 enoyl-CoA hydratase; Provisional; Region: PRK07827 216594012782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594012783 substrate binding site [chemical binding]; other site 216594012784 oxyanion hole (OAH) forming residues; other site 216594012785 trimer interface [polypeptide binding]; other site 216594012786 PE family; Region: PE; pfam00934 216594012787 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 216594012788 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 216594012789 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216594012790 metal ion-dependent adhesion site (MIDAS); other site 216594012791 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 216594012792 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 216594012793 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 216594012794 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 216594012795 purine monophosphate binding site [chemical binding]; other site 216594012796 dimer interface [polypeptide binding]; other site 216594012797 putative catalytic residues [active] 216594012798 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 216594012799 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 216594012800 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 216594012801 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 216594012802 active site 216594012803 substrate binding site [chemical binding]; other site 216594012804 cosubstrate binding site; other site 216594012805 catalytic site [active] 216594012806 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594012807 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594012808 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 216594012809 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 216594012810 active site 216594012811 PE family; Region: PE; pfam00934 216594012812 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 216594012813 CoA binding domain; Region: CoA_binding; smart00881 216594012814 CoA-ligase; Region: Ligase_CoA; pfam00549 216594012815 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 216594012816 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 216594012817 CoA-ligase; Region: Ligase_CoA; pfam00549 216594012818 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216594012819 Peptidase family M23; Region: Peptidase_M23; pfam01551 216594012820 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 216594012821 Part of AAA domain; Region: AAA_19; pfam13245 216594012822 Family description; Region: UvrD_C_2; pfam13538 216594012823 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012824 PPE family; Region: PPE; pfam00823 216594012825 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012826 hypothetical protein; Provisional; Region: PRK07857 216594012827 Putative esterase; Region: Esterase; pfam00756 216594012828 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 216594012829 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 216594012830 active site 216594012831 dimer interface [polypeptide binding]; other site 216594012832 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 216594012833 dimer interface [polypeptide binding]; other site 216594012834 active site 216594012835 short chain dehydrogenase; Provisional; Region: PRK08251 216594012836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594012837 NAD(P) binding site [chemical binding]; other site 216594012838 active site 216594012839 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 216594012840 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 216594012841 putative DNA binding site [nucleotide binding]; other site 216594012842 catalytic residue [active] 216594012843 putative H2TH interface [polypeptide binding]; other site 216594012844 putative catalytic residues [active] 216594012845 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 216594012846 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216594012847 PE family; Region: PE; pfam00934 216594012848 PE family; Region: PE; pfam00934 216594012849 PE family; Region: PE; pfam00934 216594012850 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 216594012851 active site 216594012852 SAM binding site [chemical binding]; other site 216594012853 homodimer interface [polypeptide binding]; other site 216594012854 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 216594012855 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 216594012856 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594012857 NAD binding site [chemical binding]; other site 216594012858 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216594012859 anti sigma factor interaction site; other site 216594012860 regulatory phosphorylation site [posttranslational modification]; other site 216594012861 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 216594012862 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594012863 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594012864 enoyl-CoA hydratase; Provisional; Region: PRK06688 216594012865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594012866 substrate binding site [chemical binding]; other site 216594012867 oxyanion hole (OAH) forming residues; other site 216594012868 trimer interface [polypeptide binding]; other site 216594012869 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594012870 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594012871 PE family; Region: PE; pfam00934 216594012872 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216594012873 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216594012874 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216594012875 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 216594012876 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 216594012877 nucleotide binding site [chemical binding]; other site 216594012878 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 216594012879 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 216594012880 active site 216594012881 DNA binding site [nucleotide binding] 216594012882 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 216594012883 DNA binding site [nucleotide binding] 216594012884 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216594012885 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 216594012886 putative substrate binding site [chemical binding]; other site 216594012887 putative ATP binding site [chemical binding]; other site 216594012888 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 216594012889 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 216594012890 putative DNA binding site [nucleotide binding]; other site 216594012891 putative homodimer interface [polypeptide binding]; other site 216594012892 PBP superfamily domain; Region: PBP_like_2; cl17296 216594012893 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594012894 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594012895 active site 216594012896 ATP binding site [chemical binding]; other site 216594012897 substrate binding site [chemical binding]; other site 216594012898 activation loop (A-loop); other site 216594012899 Uncharacterized conserved protein [Function unknown]; Region: COG3391 216594012900 NHL repeat; Region: NHL; pfam01436 216594012901 NHL repeat; Region: NHL; pfam01436 216594012902 NHL repeat; Region: NHL; pfam01436 216594012903 NHL repeat; Region: NHL; pfam01436 216594012904 NHL repeat; Region: NHL; pfam01436 216594012905 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 216594012906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594012907 dimer interface [polypeptide binding]; other site 216594012908 conserved gate region; other site 216594012909 putative PBP binding loops; other site 216594012910 ABC-ATPase subunit interface; other site 216594012911 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 216594012912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594012913 dimer interface [polypeptide binding]; other site 216594012914 conserved gate region; other site 216594012915 putative PBP binding loops; other site 216594012916 ABC-ATPase subunit interface; other site 216594012917 PBP superfamily domain; Region: PBP_like_2; cl17296 216594012918 short chain dehydrogenase; Provisional; Region: PRK07814 216594012919 classical (c) SDRs; Region: SDR_c; cd05233 216594012920 NAD(P) binding site [chemical binding]; other site 216594012921 active site 216594012922 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 216594012923 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 216594012924 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216594012925 manganese transport protein MntH; Reviewed; Region: PRK00701 216594012926 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 216594012927 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 216594012928 putative active site pocket [active] 216594012929 dimerization interface [polypeptide binding]; other site 216594012930 putative catalytic residue [active] 216594012931 Protein of unknown function (DUF867); Region: DUF867; pfam05908 216594012932 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 216594012933 bacteriophage phiMmar04; MURD130; Putative prophage, insertion at arginine tRNA gene 216594012934 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 216594012935 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216594012936 DNA binding residues [nucleotide binding] 216594012937 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216594012938 Protein of unknown function (DUF433); Region: DUF433; pfam04255 216594012939 Transposase; Region: HTH_Tnp_1; cl17663 216594012940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216594012941 Transposase; Region: HTH_Tnp_1; cl17663 216594012942 Transposase; Region: HTH_Tnp_1; pfam01527 216594012943 putative transposase OrfB; Reviewed; Region: PHA02517 216594012944 HTH-like domain; Region: HTH_21; pfam13276 216594012945 Integrase core domain; Region: rve; pfam00665 216594012946 Integrase core domain; Region: rve_3; pfam13683 216594012947 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 216594012948 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216594012949 CoenzymeA binding site [chemical binding]; other site 216594012950 subunit interaction site [polypeptide binding]; other site 216594012951 PHB binding site; other site 216594012952 PE family; Region: PE; pfam00934 216594012953 Transposase IS200 like; Region: Y1_Tnp; pfam01797 216594012954 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012955 PPE family; Region: PPE; pfam00823 216594012956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594012957 S-adenosylmethionine binding site [chemical binding]; other site 216594012958 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 216594012959 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 216594012960 PE family; Region: PE; pfam00934 216594012961 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012962 PPE family; Region: PPE; pfam00823 216594012963 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594012964 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 216594012965 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594012966 active site 216594012967 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 216594012968 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 216594012969 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216594012970 active site 216594012971 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 216594012972 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 216594012973 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594012974 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216594012975 hydrophobic ligand binding site; other site 216594012976 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 216594012977 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012978 PPE family; Region: PPE; pfam00823 216594012979 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012980 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012981 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012982 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012983 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012984 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012985 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012986 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012987 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012988 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012989 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012990 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012991 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012992 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594012993 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012994 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594012995 MURD131; Overlaps a CDS encoding a very large PPE family protein 216594012996 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594012997 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 216594012998 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594012999 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594013000 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594013001 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 216594013002 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216594013003 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 216594013004 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594013005 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594013006 substrate binding site [chemical binding]; other site 216594013007 oxyanion hole (OAH) forming residues; other site 216594013008 trimer interface [polypeptide binding]; other site 216594013009 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 216594013010 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216594013011 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594013012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594013013 putative substrate translocation pore; other site 216594013014 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216594013015 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594013016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594013017 catalytic residue [active] 216594013018 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216594013019 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216594013020 dimer interface [polypeptide binding]; other site 216594013021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594013022 catalytic residue [active] 216594013023 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 216594013024 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 216594013025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013026 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 216594013027 FAD binding domain; Region: FAD_binding_2; pfam00890 216594013028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594013029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594013030 active site 216594013031 phosphorylation site [posttranslational modification] 216594013032 intermolecular recognition site; other site 216594013033 dimerization interface [polypeptide binding]; other site 216594013034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594013035 DNA binding site [nucleotide binding] 216594013036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216594013037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594013038 dimerization interface [polypeptide binding]; other site 216594013039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594013040 dimer interface [polypeptide binding]; other site 216594013041 phosphorylation site [posttranslational modification] 216594013042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594013043 ATP binding site [chemical binding]; other site 216594013044 Mg2+ binding site [ion binding]; other site 216594013045 G-X-G motif; other site 216594013046 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 216594013047 BON domain; Region: BON; pfam04972 216594013048 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216594013049 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216594013050 ligand binding site [chemical binding]; other site 216594013051 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 216594013052 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216594013053 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594013054 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 216594013055 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 216594013056 dimer interface [polypeptide binding]; other site 216594013057 active site 216594013058 citrylCoA binding site [chemical binding]; other site 216594013059 NADH binding [chemical binding]; other site 216594013060 cationic pore residues; other site 216594013061 oxalacetate/citrate binding site [chemical binding]; other site 216594013062 coenzyme A binding site [chemical binding]; other site 216594013063 catalytic triad [active] 216594013064 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594013065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594013066 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 216594013067 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 216594013068 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 216594013069 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 216594013070 dimer interface [polypeptide binding]; other site 216594013071 Citrate synthase; Region: Citrate_synt; pfam00285 216594013072 active site 216594013073 citrylCoA binding site [chemical binding]; other site 216594013074 oxalacetate/citrate binding site [chemical binding]; other site 216594013075 coenzyme A binding site [chemical binding]; other site 216594013076 catalytic triad [active] 216594013077 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216594013078 putative catalytic site [active] 216594013079 putative phosphate binding site [ion binding]; other site 216594013080 putative metal binding site [ion binding]; other site 216594013081 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 216594013082 putative dimer interface [polypeptide binding]; other site 216594013083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594013084 Ferredoxin [Energy production and conversion]; Region: COG1146 216594013085 4Fe-4S binding domain; Region: Fer4; pfam00037 216594013086 ferredoxin-NADP+ reductase; Region: PLN02852 216594013087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594013088 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 216594013089 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594013090 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594013091 catalytic residue [active] 216594013092 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 216594013093 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 216594013094 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216594013095 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216594013096 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216594013097 MarR family; Region: MarR; pfam01047 216594013098 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216594013099 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 216594013100 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216594013101 hydrophobic ligand binding site; other site 216594013102 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 216594013103 H+ Antiporter protein; Region: 2A0121; TIGR00900 216594013104 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 216594013105 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 216594013106 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 216594013107 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 216594013108 putative dimer interface [polypeptide binding]; other site 216594013109 N-terminal domain interface [polypeptide binding]; other site 216594013110 putative substrate binding pocket (H-site) [chemical binding]; other site 216594013111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013112 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 216594013113 active site 216594013114 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216594013115 DNA-binding site [nucleotide binding]; DNA binding site 216594013116 RNA-binding motif; other site 216594013117 hypothetical protein; Provisional; Region: PRK11770 216594013118 Domain of unknown function (DUF307); Region: DUF307; pfam03733 216594013119 Domain of unknown function (DUF307); Region: DUF307; pfam03733 216594013120 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 216594013121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216594013122 FeS/SAM binding site; other site 216594013123 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 216594013124 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 216594013125 MoaE interaction surface [polypeptide binding]; other site 216594013126 MoeB interaction surface [polypeptide binding]; other site 216594013127 thiocarboxylated glycine; other site 216594013128 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 216594013129 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 216594013130 MoaE homodimer interface [polypeptide binding]; other site 216594013131 MoaD interaction [polypeptide binding]; other site 216594013132 active site residues [active] 216594013133 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 216594013134 MPT binding site; other site 216594013135 trimer interface [polypeptide binding]; other site 216594013136 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 216594013137 trimer interface [polypeptide binding]; other site 216594013138 dimer interface [polypeptide binding]; other site 216594013139 putative active site [active] 216594013140 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 216594013141 WYL domain; Region: WYL; pfam13280 216594013142 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 216594013143 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 216594013144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594013145 ATP binding site [chemical binding]; other site 216594013146 putative Mg++ binding site [ion binding]; other site 216594013147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594013148 nucleotide binding region [chemical binding]; other site 216594013149 ATP-binding site [chemical binding]; other site 216594013150 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594013151 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 216594013152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013154 hypothetical protein; Provisional; Region: PRK07588 216594013155 hypothetical protein; Provisional; Region: PRK07236 216594013156 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 216594013157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594013158 substrate binding site [chemical binding]; other site 216594013159 oxyanion hole (OAH) forming residues; other site 216594013160 trimer interface [polypeptide binding]; other site 216594013161 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216594013162 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216594013163 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 216594013164 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594013165 dimer interface [polypeptide binding]; other site 216594013166 active site 216594013167 aminotransferase; Validated; Region: PRK07777 216594013168 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594013169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594013170 homodimer interface [polypeptide binding]; other site 216594013171 catalytic residue [active] 216594013172 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 216594013173 putative hydrophobic ligand binding site [chemical binding]; other site 216594013174 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 216594013175 putative hydrophobic ligand binding site [chemical binding]; other site 216594013176 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594013177 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594013178 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 216594013179 putative hydrophobic ligand binding site [chemical binding]; other site 216594013180 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 216594013181 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 216594013182 dimer interface [polypeptide binding]; other site 216594013183 PYR/PP interface [polypeptide binding]; other site 216594013184 TPP binding site [chemical binding]; other site 216594013185 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216594013186 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 216594013187 TPP-binding site [chemical binding]; other site 216594013188 dimer interface [polypeptide binding]; other site 216594013189 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 216594013190 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594013191 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 216594013192 acyl-activating enzyme (AAE) consensus motif; other site 216594013193 acyl-activating enzyme (AAE) consensus motif; other site 216594013194 putative AMP binding site [chemical binding]; other site 216594013195 putative active site [active] 216594013196 putative CoA binding site [chemical binding]; other site 216594013197 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594013198 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 216594013199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594013200 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594013201 substrate binding site [chemical binding]; other site 216594013202 oxyanion hole (OAH) forming residues; other site 216594013203 trimer interface [polypeptide binding]; other site 216594013204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013207 Cytochrome P450; Region: p450; cl12078 216594013208 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 216594013209 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 216594013210 Subunit I/III interface [polypeptide binding]; other site 216594013211 MURD132; Contains six CDS encoding MCE4-family proteins. These are putative invasin-like exported proteins (Mce4A- F), possibly involved in entry and survival of mycobacteria inside macrophages 216594013212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013214 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013215 mce related protein; Region: MCE; pfam02470 216594013216 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013217 mce related protein; Region: MCE; pfam02470 216594013218 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594013219 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013220 mce related protein; Region: MCE; pfam02470 216594013221 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013222 mce related protein; Region: MCE; pfam02470 216594013223 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594013224 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013225 mce related protein; Region: MCE; pfam02470 216594013226 mce related protein; Region: MCE; pfam02470 216594013227 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594013228 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594013229 Permease; Region: Permease; pfam02405 216594013230 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594013231 Permease; Region: Permease; pfam02405 216594013232 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594013233 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594013234 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 216594013235 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 216594013236 NAD binding site [chemical binding]; other site 216594013237 catalytic residues [active] 216594013238 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594013239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594013240 NAD(P) binding site [chemical binding]; other site 216594013241 active site 216594013242 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 216594013243 Cytochrome P450; Region: p450; cl12078 216594013244 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013245 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013246 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013247 active site 216594013248 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013249 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594013250 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013251 active site 216594013252 SnoaL-like domain; Region: SnoaL_4; pfam13577 216594013253 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 216594013254 FMN binding site [chemical binding]; other site 216594013255 dimer interface [polypeptide binding]; other site 216594013256 MURD133; CDS in this region encode proteins with various roles in intermediary metabolism - possibly fatty-acid degradation. Includes a phoshoplipase C orthologue, two P450 hydroxylases, beta-oxidation enzymes, and a PE-PGRS family protein 216594013257 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216594013258 Phosphoesterase family; Region: Phosphoesterase; pfam04185 216594013259 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 216594013260 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594013261 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594013262 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 216594013263 iron-sulfur cluster [ion binding]; other site 216594013264 [2Fe-2S] cluster binding site [ion binding]; other site 216594013265 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594013266 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 216594013267 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 216594013268 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 216594013269 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 216594013270 DUF35 OB-fold domain; Region: DUF35; pfam01796 216594013271 lipid-transfer protein; Provisional; Region: PRK07855 216594013272 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594013273 active site 216594013274 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594013275 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 216594013276 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013277 Cytochrome P450; Region: p450; cl12078 216594013278 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 216594013279 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 216594013280 PE family; Region: PE; pfam00934 216594013281 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 216594013282 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013283 Cytochrome P450; Region: p450; cl12078 216594013284 TetR family transcriptional regulator; Provisional; Region: PRK14996 216594013285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013286 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 216594013287 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594013288 dimer interface [polypeptide binding]; other site 216594013289 active site 216594013290 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013292 active site 216594013293 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594013294 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216594013295 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216594013296 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594013297 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216594013298 [2Fe-2S] cluster binding site [ion binding]; other site 216594013299 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 216594013300 alpha subunit interface [polypeptide binding]; other site 216594013301 active site 216594013302 substrate binding site [chemical binding]; other site 216594013303 Fe binding site [ion binding]; other site 216594013304 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 216594013305 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594013306 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 216594013307 active site 216594013308 SnoaL-like domain; Region: SnoaL_4; pfam13577 216594013309 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013311 active site 216594013312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013314 high affinity sulphate transporter 1; Region: sulP; TIGR00815 216594013315 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 216594013316 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216594013317 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 216594013318 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013319 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013320 active site 216594013321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013323 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013324 Cytochrome P450; Region: p450; cl12078 216594013325 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 216594013326 classical (c) SDRs; Region: SDR_c; cd05233 216594013327 NAD(P) binding site [chemical binding]; other site 216594013328 active site 216594013329 short chain dehydrogenase; Provisional; Region: PRK05876 216594013330 classical (c) SDRs; Region: SDR_c; cd05233 216594013331 NAD(P) binding site [chemical binding]; other site 216594013332 active site 216594013333 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594013334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594013335 NAD(P) binding site [chemical binding]; other site 216594013336 active site 216594013337 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594013338 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594013339 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594013340 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594013341 enoyl-CoA hydratase; Provisional; Region: PRK12478 216594013342 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594013343 substrate binding site [chemical binding]; other site 216594013344 oxyanion hole (OAH) forming residues; other site 216594013345 trimer interface [polypeptide binding]; other site 216594013346 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216594013347 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216594013348 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 216594013349 active site 216594013350 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216594013351 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216594013352 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 216594013353 active site 216594013354 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594013355 Cytochrome P450; Region: p450; cl12078 216594013356 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013357 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 216594013358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013359 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 216594013360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594013361 NAD(P) binding site [chemical binding]; other site 216594013362 active site 216594013363 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216594013364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594013365 active site 216594013366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594013367 putative substrate translocation pore; other site 216594013368 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216594013369 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216594013370 dimer interface [polypeptide binding]; other site 216594013371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594013372 catalytic residue [active] 216594013373 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 216594013374 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 216594013375 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 216594013376 Multicopper oxidase; Region: Cu-oxidase; pfam00394 216594013377 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 216594013378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594013379 TAP-like protein; Region: Abhydrolase_4; pfam08386 216594013380 Putative cyclase; Region: Cyclase; pfam04199 216594013381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594013382 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216594013383 NAD(P) binding site [chemical binding]; other site 216594013384 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 216594013385 active site 216594013386 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 216594013387 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594013388 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 216594013389 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 216594013390 active site 216594013391 metal binding site [ion binding]; metal-binding site 216594013392 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 216594013393 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216594013394 MURD134; function Unknown, contains two CDS encoding hypothetical hydrolases 216594013395 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594013396 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594013397 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216594013398 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216594013399 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 216594013400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216594013401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594013402 ATP binding site [chemical binding]; other site 216594013403 Mg2+ binding site [ion binding]; other site 216594013404 G-X-G motif; other site 216594013405 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216594013406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594013407 active site 216594013408 phosphorylation site [posttranslational modification] 216594013409 intermolecular recognition site; other site 216594013410 dimerization interface [polypeptide binding]; other site 216594013411 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216594013412 DNA binding residues [nucleotide binding] 216594013413 dimerization interface [polypeptide binding]; other site 216594013414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216594013415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594013416 ATP binding site [chemical binding]; other site 216594013417 Mg2+ binding site [ion binding]; other site 216594013418 G-X-G motif; other site 216594013419 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 216594013420 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 216594013421 TPP-binding site [chemical binding]; other site 216594013422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594013423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216594013424 putative substrate translocation pore; other site 216594013425 PE family; Region: PE; pfam00934 216594013426 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 216594013427 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 216594013428 Walker A; other site 216594013429 putative acyltransferase; Provisional; Region: PRK05790 216594013430 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594013431 dimer interface [polypeptide binding]; other site 216594013432 active site 216594013433 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 216594013434 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594013435 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594013436 substrate binding site [chemical binding]; other site 216594013437 oxyanion hole (OAH) forming residues; other site 216594013438 trimer interface [polypeptide binding]; other site 216594013439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013441 active site 216594013442 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013443 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594013444 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 216594013445 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594013446 acyl-activating enzyme (AAE) consensus motif; other site 216594013447 AMP binding site [chemical binding]; other site 216594013448 active site 216594013449 CoA binding site [chemical binding]; other site 216594013450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594013451 catalytic loop [active] 216594013452 iron binding site [ion binding]; other site 216594013453 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216594013454 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216594013455 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 216594013456 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594013457 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 216594013458 B12 binding site [chemical binding]; other site 216594013459 cobalt ligand [ion binding]; other site 216594013460 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 216594013461 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216594013462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594013463 S-adenosylmethionine binding site [chemical binding]; other site 216594013464 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 216594013465 Cellulose binding domain; Region: CBM_2; pfam00553 216594013466 CBD_II domain; Region: CBD_II; smart00637 216594013467 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216594013468 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216594013469 substrate binding pocket [chemical binding]; other site 216594013470 chain length determination region; other site 216594013471 substrate-Mg2+ binding site; other site 216594013472 catalytic residues [active] 216594013473 aspartate-rich region 1; other site 216594013474 active site lid residues [active] 216594013475 aspartate-rich region 2; other site 216594013476 phytoene desaturase; Region: crtI_fam; TIGR02734 216594013477 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 216594013478 active site lid residues [active] 216594013479 substrate binding pocket [chemical binding]; other site 216594013480 catalytic residues [active] 216594013481 substrate-Mg2+ binding site; other site 216594013482 aspartate-rich region 1; other site 216594013483 aspartate-rich region 2; other site 216594013484 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 216594013485 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 216594013486 MMPL family; Region: MMPL; pfam03176 216594013487 MMPL family; Region: MMPL; pfam03176 216594013488 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216594013489 MarR family; Region: MarR_2; pfam12802 216594013490 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 216594013491 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 216594013492 homotetramer interface [polypeptide binding]; other site 216594013493 FMN binding site [chemical binding]; other site 216594013494 homodimer contacts [polypeptide binding]; other site 216594013495 putative active site [active] 216594013496 putative substrate binding site [chemical binding]; other site 216594013497 RES domain; Region: RES; pfam08808 216594013498 Helix-turn-helix domain; Region: HTH_17; pfam12728 216594013499 L-asparagine permease; Provisional; Region: PRK15049 216594013500 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 216594013501 Predicted ATPase [General function prediction only]; Region: COG3911 216594013502 AAA domain; Region: AAA_28; pfam13521 216594013503 hypothetical protein; Provisional; Region: PRK06194 216594013504 classical (c) SDRs; Region: SDR_c; cd05233 216594013505 NAD(P) binding site [chemical binding]; other site 216594013506 active site 216594013507 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 216594013508 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594013509 Amidohydrolase; Region: Amidohydro_2; pfam04909 216594013510 PE family; Region: PE; pfam00934 216594013511 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216594013512 DNA-binding site [nucleotide binding]; DNA binding site 216594013513 RNA-binding motif; other site 216594013514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 216594013515 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216594013516 ATP binding site [chemical binding]; other site 216594013517 putative Mg++ binding site [ion binding]; other site 216594013518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216594013519 nucleotide binding region [chemical binding]; other site 216594013520 ATP-binding site [chemical binding]; other site 216594013521 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 216594013522 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 216594013523 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 216594013524 substrate binding pocket [chemical binding]; other site 216594013525 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 216594013526 B12 binding site [chemical binding]; other site 216594013527 cobalt ligand [ion binding]; other site 216594013528 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 216594013529 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 216594013530 active site 216594013531 NTP binding site [chemical binding]; other site 216594013532 metal binding triad [ion binding]; metal-binding site 216594013533 bacteriophage phiMmar05; MURD135; Putative prophage, integrated at a phenylalanine tRNA 216594013534 Abi-like protein; Region: Abi_2; pfam07751 216594013535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013537 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013538 Cytochrome P450; Region: p450; cl12078 216594013539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013541 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 216594013542 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 216594013543 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594013544 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594013545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013547 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 216594013548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013549 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 216594013550 nudix motif; other site 216594013551 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216594013552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216594013553 DNA-binding site [nucleotide binding]; DNA binding site 216594013554 UTRA domain; Region: UTRA; pfam07702 216594013555 Transposase; Region: HTH_Tnp_1; pfam01527 216594013556 putative transposase OrfB; Reviewed; Region: PHA02517 216594013557 HTH-like domain; Region: HTH_21; pfam13276 216594013558 Integrase core domain; Region: rve; pfam00665 216594013559 Integrase core domain; Region: rve_3; pfam13683 216594013560 Helix-turn-helix domain; Region: HTH_17; pfam12728 216594013561 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 216594013562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216594013563 active site 216594013564 DNA binding site [nucleotide binding] 216594013565 Int/Topo IB signature motif; other site 216594013566 TIGR04255 family protein; Region: sporadTIGR04255 216594013567 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594013568 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594013569 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 216594013570 nucleoside/Zn binding site; other site 216594013571 dimer interface [polypeptide binding]; other site 216594013572 catalytic motif [active] 216594013573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594013574 dimerization interface [polypeptide binding]; other site 216594013575 putative DNA binding site [nucleotide binding]; other site 216594013576 putative Zn2+ binding site [ion binding]; other site 216594013577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 216594013578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013579 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 216594013580 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 216594013581 homodimer interface [polypeptide binding]; other site 216594013582 putative substrate binding pocket [chemical binding]; other site 216594013583 diiron center [ion binding]; other site 216594013584 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 216594013585 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 216594013586 FMN binding site [chemical binding]; other site 216594013587 active site 216594013588 catalytic residues [active] 216594013589 substrate binding site [chemical binding]; other site 216594013590 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 216594013591 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 216594013592 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 216594013593 PhoU domain; Region: PhoU; pfam01895 216594013594 PhoU domain; Region: PhoU; pfam01895 216594013595 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 216594013596 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 216594013597 Walker A/P-loop; other site 216594013598 ATP binding site [chemical binding]; other site 216594013599 Q-loop/lid; other site 216594013600 ABC transporter signature motif; other site 216594013601 Walker B; other site 216594013602 D-loop; other site 216594013603 H-loop/switch region; other site 216594013604 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 216594013605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594013606 dimer interface [polypeptide binding]; other site 216594013607 conserved gate region; other site 216594013608 putative PBP binding loops; other site 216594013609 ABC-ATPase subunit interface; other site 216594013610 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 216594013611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594013612 dimer interface [polypeptide binding]; other site 216594013613 conserved gate region; other site 216594013614 putative PBP binding loops; other site 216594013615 ABC-ATPase subunit interface; other site 216594013616 PBP superfamily domain; Region: PBP_like_2; cl17296 216594013617 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 216594013618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594013619 Coenzyme A binding pocket [chemical binding]; other site 216594013620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216594013621 Coenzyme A binding pocket [chemical binding]; other site 216594013622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594013623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594013624 DNA binding site [nucleotide binding] 216594013625 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 216594013626 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 216594013627 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 216594013628 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 216594013629 active site residue [active] 216594013630 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 216594013631 active site residue [active] 216594013632 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 216594013633 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 216594013634 heme-binding site [chemical binding]; other site 216594013635 RyR domain; Region: RyR; pfam02026 216594013636 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 216594013637 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 216594013638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594013639 catalytic residue [active] 216594013640 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 216594013641 putative homodimer interface [polypeptide binding]; other site 216594013642 putative homotetramer interface [polypeptide binding]; other site 216594013643 allosteric switch controlling residues; other site 216594013644 putative metal binding site [ion binding]; other site 216594013645 putative homodimer-homodimer interface [polypeptide binding]; other site 216594013646 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 216594013647 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216594013648 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216594013649 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216594013650 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 216594013651 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 216594013652 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216594013653 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 216594013654 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 216594013655 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 216594013656 dimerization interface [polypeptide binding]; other site 216594013657 putative ATP binding site [chemical binding]; other site 216594013658 amidophosphoribosyltransferase; Provisional; Region: PRK07847 216594013659 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 216594013660 active site 216594013661 tetramer interface [polypeptide binding]; other site 216594013662 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216594013663 active site 216594013664 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013665 mce related protein; Region: MCE; pfam02470 216594013666 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594013667 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216594013668 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 216594013669 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 216594013670 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 216594013671 active site 216594013672 metal binding site [ion binding]; metal-binding site 216594013673 hexamer interface [polypeptide binding]; other site 216594013674 CAAX protease self-immunity; Region: Abi; pfam02517 216594013675 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 216594013676 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 216594013677 dimerization interface [polypeptide binding]; other site 216594013678 ATP binding site [chemical binding]; other site 216594013679 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 216594013680 dimerization interface [polypeptide binding]; other site 216594013681 ATP binding site [chemical binding]; other site 216594013682 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216594013683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216594013684 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216594013685 active site 216594013686 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594013687 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 216594013688 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 216594013689 active site 216594013690 metal binding site [ion binding]; metal-binding site 216594013691 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 216594013692 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 216594013693 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 216594013694 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594013695 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216594013696 Cupin domain; Region: Cupin_2; cl17218 216594013697 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 216594013698 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 216594013699 putative active site [active] 216594013700 catalytic triad [active] 216594013701 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 216594013702 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594013703 PPE family; Region: PPE; pfam00823 216594013704 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216594013705 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 216594013706 MURD155; Overlaps a CDS encoding a putative hydrolase 216594013707 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594013708 putative DNA binding site [nucleotide binding]; other site 216594013709 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 216594013710 putative Zn2+ binding site [ion binding]; other site 216594013711 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 216594013712 putative dimerization interface [polypeptide binding]; other site 216594013713 EamA-like transporter family; Region: EamA; pfam00892 216594013714 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 216594013715 Predicted deacetylase [General function prediction only]; Region: COG3233 216594013716 putative active site [active] 216594013717 putative Zn binding site [ion binding]; other site 216594013718 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594013719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594013720 putative substrate translocation pore; other site 216594013721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594013722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013724 WHG domain; Region: WHG; pfam13305 216594013725 Predicted membrane protein [Function unknown]; Region: COG4270 216594013726 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 216594013727 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216594013728 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 216594013729 ATP binding site [chemical binding]; other site 216594013730 active site 216594013731 substrate binding site [chemical binding]; other site 216594013732 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216594013733 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 216594013734 NAD binding site [chemical binding]; other site 216594013735 substrate binding site [chemical binding]; other site 216594013736 catalytic Zn binding site [ion binding]; other site 216594013737 tetramer interface [polypeptide binding]; other site 216594013738 structural Zn binding site [ion binding]; other site 216594013739 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 216594013740 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216594013741 NAD(P) binding site [chemical binding]; other site 216594013742 catalytic residues [active] 216594013743 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 216594013744 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594013745 PPE family; Region: PPE; pfam00823 216594013746 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013747 Cytochrome P450; Region: p450; cl12078 216594013748 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 216594013749 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 216594013750 tetramer interface [polypeptide binding]; other site 216594013751 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 216594013752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 216594013753 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 216594013754 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216594013755 hypothetical protein; Provisional; Region: PRK07877 216594013756 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 216594013757 ATP binding site [chemical binding]; other site 216594013758 substrate interface [chemical binding]; other site 216594013759 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594013760 Ligand Binding Site [chemical binding]; other site 216594013761 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594013762 Ligand Binding Site [chemical binding]; other site 216594013763 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216594013764 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216594013765 active site 216594013766 ATP binding site [chemical binding]; other site 216594013767 substrate binding site [chemical binding]; other site 216594013768 activation loop (A-loop); other site 216594013769 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594013770 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 216594013771 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 216594013772 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 216594013773 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 216594013774 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 216594013775 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216594013776 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 216594013777 short chain dehydrogenase; Provisional; Region: PRK07774 216594013778 classical (c) SDRs; Region: SDR_c; cd05233 216594013779 NAD(P) binding site [chemical binding]; other site 216594013780 active site 216594013781 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 216594013782 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 216594013783 NAD binding site [chemical binding]; other site 216594013784 catalytic residues [active] 216594013785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594013786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594013787 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013788 Cytochrome P450; Region: p450; cl12078 216594013789 short chain dehydrogenase; Provisional; Region: PRK07775 216594013790 classical (c) SDRs; Region: SDR_c; cd05233 216594013791 NAD(P) binding site [chemical binding]; other site 216594013792 active site 216594013793 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013794 Cytochrome P450; Region: p450; cl12078 216594013795 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 216594013796 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 216594013797 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 216594013798 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 216594013799 NAD binding site [chemical binding]; other site 216594013800 catalytic Zn binding site [ion binding]; other site 216594013801 substrate binding site [chemical binding]; other site 216594013802 structural Zn binding site [ion binding]; other site 216594013803 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216594013804 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 216594013805 PE family; Region: PE; pfam00934 216594013806 PE-PPE domain; Region: PE-PPE; pfam08237 216594013807 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 216594013808 nucleotide binding site/active site [active] 216594013809 HIT family signature motif; other site 216594013810 catalytic residue [active] 216594013811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216594013812 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594013813 dimerization interface [polypeptide binding]; other site 216594013814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594013815 dimer interface [polypeptide binding]; other site 216594013816 phosphorylation site [posttranslational modification] 216594013817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594013818 ATP binding site [chemical binding]; other site 216594013819 Mg2+ binding site [ion binding]; other site 216594013820 G-X-G motif; other site 216594013821 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594013822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594013823 active site 216594013824 phosphorylation site [posttranslational modification] 216594013825 intermolecular recognition site; other site 216594013826 dimerization interface [polypeptide binding]; other site 216594013827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594013828 DNA binding site [nucleotide binding] 216594013829 hypothetical protein; Provisional; Region: PRK07236 216594013830 salicylate hydroxylase; Provisional; Region: PRK08163 216594013831 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216594013832 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594013833 catalytic loop [active] 216594013834 iron binding site [ion binding]; other site 216594013835 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216594013836 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 216594013837 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 216594013838 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216594013839 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 216594013840 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 216594013841 active site 216594013842 homotetramer interface [polypeptide binding]; other site 216594013843 putative OHCU decarboxylase; Provisional; Region: PRK13798 216594013844 xanthine permease; Region: pbuX; TIGR03173 216594013845 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 216594013846 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216594013847 Sulfatase; Region: Sulfatase; pfam00884 216594013848 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 216594013849 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216594013850 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594013851 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594013852 substrate binding site [chemical binding]; other site 216594013853 oxyanion hole (OAH) forming residues; other site 216594013854 trimer interface [polypeptide binding]; other site 216594013855 PE family; Region: PE; pfam00934 216594013856 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594013857 catalytic core [active] 216594013858 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 216594013859 Amidase; Region: Amidase; cl11426 216594013860 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594013861 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594013862 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 216594013863 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216594013864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594013865 putative substrate translocation pore; other site 216594013866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594013867 MURD136; Overlaps a unique hypothetical protein 216594013868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594013869 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216594013870 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 216594013871 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 216594013872 gating phenylalanine in ion channel; other site 216594013873 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 216594013874 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 216594013875 Transcriptional regulator [Transcription]; Region: LytR; COG1316 216594013876 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 216594013877 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594013878 classical (c) SDRs; Region: SDR_c; cd05233 216594013879 NAD(P) binding site [chemical binding]; other site 216594013880 active site 216594013881 short chain dehydrogenase; Provisional; Region: PRK05875 216594013882 classical (c) SDRs; Region: SDR_c; cd05233 216594013883 NAD(P) binding site [chemical binding]; other site 216594013884 active site 216594013885 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216594013886 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 216594013887 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594013888 acyl-activating enzyme (AAE) consensus motif; other site 216594013889 active site 216594013890 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 216594013891 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594013892 catalytic residue [active] 216594013893 enoyl-CoA hydratase; Provisional; Region: PRK08290 216594013894 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594013895 substrate binding site [chemical binding]; other site 216594013896 oxyanion hole (OAH) forming residues; other site 216594013897 trimer interface [polypeptide binding]; other site 216594013898 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 216594013899 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 216594013900 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 216594013901 Walker A/P-loop; other site 216594013902 ATP binding site [chemical binding]; other site 216594013903 Q-loop/lid; other site 216594013904 ABC transporter signature motif; other site 216594013905 Walker B; other site 216594013906 D-loop; other site 216594013907 H-loop/switch region; other site 216594013908 MURD137; Overlaps a CDS encoding a MMPL-family protein 216594013909 Transport protein; Region: actII; TIGR00833 216594013910 Predicted transcriptional regulators [Transcription]; Region: COG1695 216594013911 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216594013912 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 216594013913 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 216594013914 active site 216594013915 homotetramer interface [polypeptide binding]; other site 216594013916 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013917 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 216594013918 mce related protein; Region: MCE; pfam02470 216594013919 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013920 mce related protein; Region: MCE; pfam02470 216594013921 mce related protein; Region: MCE; pfam02470 216594013922 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013923 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013924 mce related protein; Region: MCE; pfam02470 216594013925 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013926 mce related protein; Region: MCE; pfam02470 216594013927 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594013928 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 216594013929 mce related protein; Region: MCE; pfam02470 216594013930 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 216594013931 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594013932 Permease; Region: Permease; pfam02405 216594013933 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216594013934 Permease; Region: Permease; pfam02405 216594013935 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 216594013936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594013937 NAD(P) binding site [chemical binding]; other site 216594013938 active site 216594013939 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 216594013940 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013941 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 216594013942 FAD binding site [chemical binding]; other site 216594013943 substrate binding site [chemical binding]; other site 216594013944 catalytic base [active] 216594013945 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594013946 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594013947 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216594013948 active site 216594013949 acyl-CoA synthetase; Validated; Region: PRK07867 216594013950 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 216594013951 acyl-activating enzyme (AAE) consensus motif; other site 216594013952 putative AMP binding site [chemical binding]; other site 216594013953 putative active site [active] 216594013954 putative CoA binding site [chemical binding]; other site 216594013955 PE family; Region: PE; pfam00934 216594013956 MURD138; Overlaps a large PE-PGRS family protein 216594013957 hypothetical protein; Validated; Region: PRK07586 216594013958 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216594013959 PYR/PP interface [polypeptide binding]; other site 216594013960 dimer interface [polypeptide binding]; other site 216594013961 TPP binding site [chemical binding]; other site 216594013962 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 216594013963 TPP-binding site [chemical binding]; other site 216594013964 dimer interface [polypeptide binding]; other site 216594013965 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 216594013966 MURD139; Overlaps a large PE-PGRS family protein 216594013967 PE family; Region: PE; pfam00934 216594013968 Fructosamine kinase; Region: Fructosamin_kin; cl17579 216594013969 Phosphotransferase enzyme family; Region: APH; pfam01636 216594013970 acyl-CoA synthetase; Validated; Region: PRK07798 216594013971 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594013972 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 216594013973 acyl-activating enzyme (AAE) consensus motif; other site 216594013974 acyl-activating enzyme (AAE) consensus motif; other site 216594013975 putative AMP binding site [chemical binding]; other site 216594013976 putative active site [active] 216594013977 putative CoA binding site [chemical binding]; other site 216594013978 enoyl-CoA hydratase; Provisional; Region: PRK07799 216594013979 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594013980 substrate binding site [chemical binding]; other site 216594013981 oxyanion hole (OAH) forming residues; other site 216594013982 trimer interface [polypeptide binding]; other site 216594013983 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594013984 Cytochrome P450; Region: p450; cl12078 216594013985 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 216594013986 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 216594013987 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 216594013988 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 216594013989 DUF35 OB-fold domain; Region: DUF35; pfam01796 216594013990 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 216594013991 DUF35 OB-fold domain; Region: DUF35; pfam01796 216594013992 lipid-transfer protein; Provisional; Region: PRK07937 216594013993 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594013994 active site 216594013995 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 216594013996 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594013997 active site 216594013998 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 216594013999 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594014000 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216594014001 Uncharacterized conserved protein [Function unknown]; Region: COG3391 216594014002 NHL repeat; Region: NHL; pfam01436 216594014003 NHL repeat; Region: NHL; pfam01436 216594014004 NHL repeat; Region: NHL; pfam01436 216594014005 Uncharacterized conserved protein [Function unknown]; Region: COG3391 216594014006 NHL repeat; Region: NHL; pfam01436 216594014007 NHL repeat; Region: NHL; pfam01436 216594014008 PE family; Region: PE; pfam00934 216594014009 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 216594014010 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 216594014011 trimer interface [polypeptide binding]; other site 216594014012 putative metal binding site [ion binding]; other site 216594014013 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216594014014 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 216594014015 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 216594014016 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 216594014017 short chain dehydrogenase; Provisional; Region: PRK07890 216594014018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594014019 NAD(P) binding site [chemical binding]; other site 216594014020 active site 216594014021 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 216594014022 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 216594014023 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 216594014024 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 216594014025 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 216594014026 active site 216594014027 catalytic residues [active] 216594014028 metal binding site [ion binding]; metal-binding site 216594014029 DmpG-like communication domain; Region: DmpG_comm; pfam07836 216594014030 acetaldehyde dehydrogenase; Validated; Region: PRK08300 216594014031 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 216594014032 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 216594014033 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 216594014034 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 216594014035 enoyl-CoA hydratase; Region: PLN02864 216594014036 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 216594014037 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 216594014038 dimer interaction site [polypeptide binding]; other site 216594014039 substrate-binding tunnel; other site 216594014040 active site 216594014041 catalytic site [active] 216594014042 substrate binding site [chemical binding]; other site 216594014043 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 216594014044 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 216594014045 putative active site [active] 216594014046 lipid-transfer protein; Provisional; Region: PRK07855 216594014047 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 216594014048 active site 216594014049 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 216594014050 putative active site [active] 216594014051 putative catalytic site [active] 216594014052 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 216594014053 active site 216594014054 catalytic site [active] 216594014055 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 216594014056 DUF35 OB-fold domain; Region: DUF35; pfam01796 216594014057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014058 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014059 active site 216594014060 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014061 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594014062 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014063 active site 216594014064 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594014065 Cytochrome P450; Region: p450; cl12078 216594014066 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 216594014067 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594014068 dimer interface [polypeptide binding]; other site 216594014069 active site 216594014070 Domain of unknown function (DUF385); Region: DUF385; pfam04075 216594014071 short chain dehydrogenase; Provisional; Region: PRK07791 216594014072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594014073 NAD(P) binding site [chemical binding]; other site 216594014074 active site 216594014075 short chain dehydrogenase; Provisional; Region: PRK07856 216594014076 classical (c) SDRs; Region: SDR_c; cd05233 216594014077 NAD(P) binding site [chemical binding]; other site 216594014078 active site 216594014079 PE family; Region: PE; pfam00934 216594014080 enoyl-CoA hydratase; Provisional; Region: PRK06495 216594014081 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594014082 substrate binding site [chemical binding]; other site 216594014083 oxyanion hole (OAH) forming residues; other site 216594014084 trimer interface [polypeptide binding]; other site 216594014085 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 216594014086 Coenzyme A transferase; Region: CoA_trans; cl17247 216594014087 Nitronate monooxygenase; Region: NMO; pfam03060 216594014088 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216594014089 FMN binding site [chemical binding]; other site 216594014090 substrate binding site [chemical binding]; other site 216594014091 putative catalytic residue [active] 216594014092 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 216594014093 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 216594014094 putative di-iron ligands [ion binding]; other site 216594014095 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 216594014096 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 216594014097 FAD binding pocket [chemical binding]; other site 216594014098 FAD binding motif [chemical binding]; other site 216594014099 phosphate binding motif [ion binding]; other site 216594014100 beta-alpha-beta structure motif; other site 216594014101 NAD(p) ribose binding residues [chemical binding]; other site 216594014102 NAD binding pocket [chemical binding]; other site 216594014103 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 216594014104 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594014105 catalytic loop [active] 216594014106 iron binding site [ion binding]; other site 216594014107 PE family; Region: PE; pfam00934 216594014108 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 216594014109 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216594014110 dimer interface [polypeptide binding]; other site 216594014111 active site 216594014112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594014113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594014114 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 216594014115 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594014116 PPE family; Region: PPE; pfam00823 216594014117 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594014118 short chain dehydrogenase; Provisional; Region: PRK07831 216594014119 classical (c) SDRs; Region: SDR_c; cd05233 216594014120 NAD(P) binding site [chemical binding]; other site 216594014121 active site 216594014122 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014124 active site 216594014125 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 216594014126 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594014127 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 216594014128 acyl-activating enzyme (AAE) consensus motif; other site 216594014129 acyl-activating enzyme (AAE) consensus motif; other site 216594014130 putative AMP binding site [chemical binding]; other site 216594014131 putative active site [active] 216594014132 putative CoA binding site [chemical binding]; other site 216594014133 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014134 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014135 active site 216594014136 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594014137 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014139 active site 216594014140 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014141 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594014142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014143 aspartate aminotransferase; Provisional; Region: PRK05764 216594014144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594014145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594014146 homodimer interface [polypeptide binding]; other site 216594014147 catalytic residue [active] 216594014148 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 216594014149 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 216594014150 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216594014151 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216594014152 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216594014153 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 216594014154 Peptidase family M48; Region: Peptidase_M48; cl12018 216594014155 Penicillinase repressor; Region: Pencillinase_R; cl17580 216594014156 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 216594014157 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 216594014158 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 216594014159 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 216594014160 active site 216594014161 Fe binding site [ion binding]; other site 216594014162 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 216594014163 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594014164 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 216594014165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014166 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 216594014167 Flavin binding site [chemical binding]; other site 216594014168 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216594014169 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 216594014170 FAD binding pocket [chemical binding]; other site 216594014171 FAD binding motif [chemical binding]; other site 216594014172 phosphate binding motif [ion binding]; other site 216594014173 beta-alpha-beta structure motif; other site 216594014174 NAD(p) ribose binding residues [chemical binding]; other site 216594014175 NAD binding pocket [chemical binding]; other site 216594014176 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 216594014177 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216594014178 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216594014179 catalytic loop [active] 216594014180 iron binding site [ion binding]; other site 216594014181 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014182 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216594014183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014184 active site 216594014185 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014186 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014187 active site 216594014188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594014189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594014190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216594014191 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216594014192 DNA binding site [nucleotide binding] 216594014193 domain linker motif; other site 216594014194 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 216594014195 putative dimerization interface [polypeptide binding]; other site 216594014196 putative ligand binding site [chemical binding]; other site 216594014197 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 216594014198 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 216594014199 intersubunit interface [polypeptide binding]; other site 216594014200 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 216594014201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594014202 Walker A/P-loop; other site 216594014203 ATP binding site [chemical binding]; other site 216594014204 Q-loop/lid; other site 216594014205 ABC transporter signature motif; other site 216594014206 Walker B; other site 216594014207 D-loop; other site 216594014208 H-loop/switch region; other site 216594014209 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216594014210 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 216594014211 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594014212 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594014213 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 216594014214 putative active site [active] 216594014215 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216594014216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216594014217 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 216594014218 transmembrane helices; other site 216594014219 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 216594014220 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216594014221 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 216594014222 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216594014223 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 216594014224 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216594014225 active site 216594014226 HIGH motif; other site 216594014227 nucleotide binding site [chemical binding]; other site 216594014228 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216594014229 KMSKS motif; other site 216594014230 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216594014231 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 216594014232 homotrimer interaction site [polypeptide binding]; other site 216594014233 zinc binding site [ion binding]; other site 216594014234 CDP-binding sites; other site 216594014235 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 216594014236 substrate binding site; other site 216594014237 dimer interface; other site 216594014238 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 216594014239 DNA repair protein RadA; Provisional; Region: PRK11823 216594014240 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216594014241 Walker A motif; other site 216594014242 ATP binding site [chemical binding]; other site 216594014243 Walker B motif; other site 216594014244 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 216594014245 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 216594014246 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 216594014247 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 216594014248 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 216594014249 active site clefts [active] 216594014250 zinc binding site [ion binding]; other site 216594014251 dimer interface [polypeptide binding]; other site 216594014252 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216594014253 endonuclease III; Region: ENDO3c; smart00478 216594014254 minor groove reading motif; other site 216594014255 helix-hairpin-helix signature motif; other site 216594014256 substrate binding pocket [chemical binding]; other site 216594014257 active site 216594014258 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594014259 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216594014260 catalytic site [active] 216594014261 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 216594014262 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 216594014263 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 216594014264 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 216594014265 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 216594014266 Ligand binding site; other site 216594014267 Putative Catalytic site; other site 216594014268 DXD motif; other site 216594014269 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 216594014270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594014271 putative substrate translocation pore; other site 216594014272 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216594014273 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216594014274 substrate binding pocket [chemical binding]; other site 216594014275 chain length determination region; other site 216594014276 substrate-Mg2+ binding site; other site 216594014277 catalytic residues [active] 216594014278 aspartate-rich region 1; other site 216594014279 active site lid residues [active] 216594014280 aspartate-rich region 2; other site 216594014281 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594014282 catalytic core [active] 216594014283 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 216594014284 PE family; Region: PE; pfam00934 216594014285 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 216594014286 Clp amino terminal domain; Region: Clp_N; pfam02861 216594014287 Clp amino terminal domain; Region: Clp_N; pfam02861 216594014288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594014289 Walker A motif; other site 216594014290 ATP binding site [chemical binding]; other site 216594014291 Walker B motif; other site 216594014292 arginine finger; other site 216594014293 UvrB/uvrC motif; Region: UVR; pfam02151 216594014294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594014295 Walker A motif; other site 216594014296 ATP binding site [chemical binding]; other site 216594014297 Walker B motif; other site 216594014298 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216594014299 Lsr2; Region: Lsr2; pfam11774 216594014300 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 216594014301 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 216594014302 dimer interface [polypeptide binding]; other site 216594014303 putative anticodon binding site; other site 216594014304 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216594014305 motif 1; other site 216594014306 dimer interface [polypeptide binding]; other site 216594014307 active site 216594014308 motif 2; other site 216594014309 motif 3; other site 216594014310 pantothenate kinase; Reviewed; Region: PRK13318 216594014311 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 216594014312 tetramerization interface [polypeptide binding]; other site 216594014313 active site 216594014314 Pantoate-beta-alanine ligase; Region: PanC; cd00560 216594014315 pantoate--beta-alanine ligase; Region: panC; TIGR00018 216594014316 active site 216594014317 ATP-binding site [chemical binding]; other site 216594014318 pantoate-binding site; other site 216594014319 HXXH motif; other site 216594014320 Uncharacterized conserved protein [Function unknown]; Region: COG5495 216594014321 Rossmann-like domain; Region: Rossmann-like; pfam10727 216594014322 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 216594014323 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 216594014324 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 216594014325 catalytic center binding site [active] 216594014326 ATP binding site [chemical binding]; other site 216594014327 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 216594014328 homooctamer interface [polypeptide binding]; other site 216594014329 active site 216594014330 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 216594014331 dihydropteroate synthase; Region: DHPS; TIGR01496 216594014332 substrate binding pocket [chemical binding]; other site 216594014333 dimer interface [polypeptide binding]; other site 216594014334 inhibitor binding site; inhibition site 216594014335 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 216594014336 GTP cyclohydrolase I; Provisional; Region: PLN03044 216594014337 homodecamer interface [polypeptide binding]; other site 216594014338 active site 216594014339 putative catalytic site residues [active] 216594014340 zinc binding site [ion binding]; other site 216594014341 GTP-CH-I/GFRP interaction surface; other site 216594014342 FtsH Extracellular; Region: FtsH_ext; pfam06480 216594014343 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 216594014344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594014345 Walker A motif; other site 216594014346 ATP binding site [chemical binding]; other site 216594014347 Walker B motif; other site 216594014348 arginine finger; other site 216594014349 Peptidase family M41; Region: Peptidase_M41; pfam01434 216594014350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594014351 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216594014352 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594014353 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216594014354 MURD140; Overlaps a putative dehydrogenase 216594014355 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216594014356 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 216594014357 putative NAD(P) binding site [chemical binding]; other site 216594014358 catalytic Zn binding site [ion binding]; other site 216594014359 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594014360 PPE family; Region: PPE; pfam00823 216594014361 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594014362 PE family; Region: PE; pfam00934 216594014363 MURD141; Contains CDS of an ESX-like locus 216594014364 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 216594014365 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 216594014366 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594014367 PPE family; Region: PPE; pfam00823 216594014368 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 216594014369 PE family; Region: PE; pfam00934 216594014370 Uncharacterized conserved protein [Function unknown]; Region: COG2968 216594014371 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 216594014372 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216594014373 active site 216594014374 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 216594014375 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 216594014376 Ligand Binding Site [chemical binding]; other site 216594014377 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 216594014378 putative hydrolase; Region: TIGR03624 216594014379 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 216594014380 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 216594014381 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 216594014382 dimer interface [polypeptide binding]; other site 216594014383 substrate binding site [chemical binding]; other site 216594014384 metal binding sites [ion binding]; metal-binding site 216594014385 hypothetical protein; Provisional; Region: PRK14013 216594014386 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216594014387 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 216594014388 Ligand binding site; other site 216594014389 Putative Catalytic site; other site 216594014390 DXD motif; other site 216594014391 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 216594014392 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216594014393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594014394 NAD(P) binding site [chemical binding]; other site 216594014395 active site 216594014396 PE family; Region: PE; pfam00934 216594014397 DNA polymerase III subunit delta'; Validated; Region: PRK07940 216594014398 DNA polymerase III subunit delta'; Validated; Region: PRK08485 216594014399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216594014400 dimerization interface [polypeptide binding]; other site 216594014401 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594014402 cyclase homology domain; Region: CHD; cd07302 216594014403 nucleotidyl binding site; other site 216594014404 metal binding site [ion binding]; metal-binding site 216594014405 dimer interface [polypeptide binding]; other site 216594014406 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 216594014407 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 216594014408 active site 216594014409 interdomain interaction site; other site 216594014410 putative metal-binding site [ion binding]; other site 216594014411 nucleotide binding site [chemical binding]; other site 216594014412 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 216594014413 domain I; other site 216594014414 phosphate binding site [ion binding]; other site 216594014415 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 216594014416 domain II; other site 216594014417 domain III; other site 216594014418 nucleotide binding site [chemical binding]; other site 216594014419 DNA binding groove [nucleotide binding] 216594014420 catalytic site [active] 216594014421 domain IV; other site 216594014422 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 216594014423 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 216594014424 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 216594014425 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216594014426 DNA-binding site [nucleotide binding]; DNA binding site 216594014427 RNA-binding motif; other site 216594014428 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 216594014429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216594014430 ATP binding site [chemical binding]; other site 216594014431 putative Mg++ binding site [ion binding]; other site 216594014432 nucleotide binding region [chemical binding]; other site 216594014433 helicase superfamily c-terminal domain; Region: HELICc; smart00490 216594014434 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 216594014435 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 216594014436 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 216594014437 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 216594014438 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 216594014439 ATP binding site [chemical binding]; other site 216594014440 Walker A motif; other site 216594014441 hexamer interface [polypeptide binding]; other site 216594014442 Walker B motif; other site 216594014443 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 216594014444 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216594014445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216594014446 motif II; other site 216594014447 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216594014448 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216594014449 Walker A/P-loop; other site 216594014450 ATP binding site [chemical binding]; other site 216594014451 Q-loop/lid; other site 216594014452 ABC transporter signature motif; other site 216594014453 Walker B; other site 216594014454 D-loop; other site 216594014455 H-loop/switch region; other site 216594014456 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216594014457 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216594014458 Walker A/P-loop; other site 216594014459 ATP binding site [chemical binding]; other site 216594014460 Q-loop/lid; other site 216594014461 ABC transporter signature motif; other site 216594014462 Walker B; other site 216594014463 D-loop; other site 216594014464 H-loop/switch region; other site 216594014465 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216594014466 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216594014467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594014468 dimer interface [polypeptide binding]; other site 216594014469 conserved gate region; other site 216594014470 putative PBP binding loops; other site 216594014471 ABC-ATPase subunit interface; other site 216594014472 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216594014473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594014474 dimer interface [polypeptide binding]; other site 216594014475 conserved gate region; other site 216594014476 ABC-ATPase subunit interface; other site 216594014477 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 216594014478 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216594014479 acetyl-CoA synthetase; Provisional; Region: PRK00174 216594014480 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 216594014481 active site 216594014482 CoA binding site [chemical binding]; other site 216594014483 acyl-activating enzyme (AAE) consensus motif; other site 216594014484 AMP binding site [chemical binding]; other site 216594014485 acetate binding site [chemical binding]; other site 216594014486 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 216594014487 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 216594014488 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216594014489 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 216594014490 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216594014491 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 216594014492 putative active site [active] 216594014493 putative CoA binding site [chemical binding]; other site 216594014494 nudix motif; other site 216594014495 metal binding site [ion binding]; metal-binding site 216594014496 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216594014497 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216594014498 catalytic residues [active] 216594014499 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 216594014500 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216594014501 minor groove reading motif; other site 216594014502 helix-hairpin-helix signature motif; other site 216594014503 substrate binding pocket [chemical binding]; other site 216594014504 active site 216594014505 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 216594014506 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216594014507 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216594014508 ligand binding site [chemical binding]; other site 216594014509 flexible hinge region; other site 216594014510 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216594014511 putative switch regulator; other site 216594014512 non-specific DNA interactions [nucleotide binding]; other site 216594014513 DNA binding site [nucleotide binding] 216594014514 sequence specific DNA binding site [nucleotide binding]; other site 216594014515 putative cAMP binding site [chemical binding]; other site 216594014516 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594014517 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216594014518 homotrimer interaction site [polypeptide binding]; other site 216594014519 putative active site [active] 216594014520 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 216594014521 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 216594014522 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216594014523 P loop; other site 216594014524 Nucleotide binding site [chemical binding]; other site 216594014525 DTAP/Switch II; other site 216594014526 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 216594014527 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216594014528 DTAP/Switch II; other site 216594014529 Switch I; other site 216594014530 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216594014531 Transcription factor WhiB; Region: Whib; pfam02467 216594014532 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 216594014533 Transglycosylase; Region: Transgly; pfam00912 216594014534 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 216594014535 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 216594014536 phosphodiesterase YaeI; Provisional; Region: PRK11340 216594014537 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 216594014538 putative active site [active] 216594014539 putative metal binding site [ion binding]; other site 216594014540 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216594014541 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 216594014542 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594014543 catalytic residue [active] 216594014544 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594014545 Cytochrome P450; Region: p450; cl12078 216594014546 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 216594014547 PAS fold; Region: PAS_3; pfam08447 216594014548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216594014549 putative active site [active] 216594014550 heme pocket [chemical binding]; other site 216594014551 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 216594014552 MURD142; This region contains a two-component regulator, the selenosyteine synthase, elongation factor and selenocysteine tRNA 216594014553 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216594014554 anti sigma factor interaction site; other site 216594014555 regulatory phosphorylation site [posttranslational modification]; other site 216594014556 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 216594014557 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 216594014558 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 216594014559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594014560 ATP binding site [chemical binding]; other site 216594014561 Mg2+ binding site [ion binding]; other site 216594014562 G-X-G motif; other site 216594014563 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 216594014564 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 216594014565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216594014566 PAS domain; Region: PAS_9; pfam13426 216594014567 putative active site [active] 216594014568 heme pocket [chemical binding]; other site 216594014569 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 216594014570 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 216594014571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 216594014572 Domain of unknown function (DUF222); Region: DUF222; pfam02720 216594014573 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216594014574 active site 216594014575 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 216594014576 intracellular protease, PfpI family; Region: PfpI; TIGR01382 216594014577 proposed catalytic triad [active] 216594014578 conserved cys residue [active] 216594014579 selenophosphate synthetase; Provisional; Region: PRK00943 216594014580 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 216594014581 dimerization interface [polypeptide binding]; other site 216594014582 putative ATP binding site [chemical binding]; other site 216594014583 selenocysteine synthase; Provisional; Region: PRK04311 216594014584 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 216594014585 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594014586 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 216594014587 G1 box; other site 216594014588 GTP/Mg2+ binding site [chemical binding]; other site 216594014589 G2 box; other site 216594014590 Switch I region; other site 216594014591 G3 box; other site 216594014592 Switch II region; other site 216594014593 G4 box; other site 216594014594 G5 box; other site 216594014595 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 216594014596 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 216594014597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594014598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216594014599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594014600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594014601 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216594014602 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216594014603 molybdopterin cofactor binding site; other site 216594014604 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216594014605 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 216594014606 molybdopterin cofactor binding site; other site 216594014607 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 216594014608 4Fe-4S binding domain; Region: Fer4; cl02805 216594014609 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 216594014610 Uncharacterized conserved protein [Function unknown]; Region: COG1610 216594014611 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 216594014612 MoxR-like ATPases [General function prediction only]; Region: COG0714 216594014613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594014614 Walker A motif; other site 216594014615 ATP binding site [chemical binding]; other site 216594014616 Walker B motif; other site 216594014617 arginine finger; other site 216594014618 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 216594014619 Protein of unknown function DUF58; Region: DUF58; pfam01882 216594014620 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 216594014621 Predicted membrane protein/domain [Function unknown]; Region: COG1714 216594014622 Predicted transcriptional regulators [Transcription]; Region: COG1695 216594014623 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216594014624 PE family; Region: PE; pfam00934 216594014625 glycerol kinase; Provisional; Region: glpK; PRK00047 216594014626 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 216594014627 N- and C-terminal domain interface [polypeptide binding]; other site 216594014628 active site 216594014629 MgATP binding site [chemical binding]; other site 216594014630 catalytic site [active] 216594014631 metal binding site [ion binding]; metal-binding site 216594014632 putative homotetramer interface [polypeptide binding]; other site 216594014633 glycerol binding site [chemical binding]; other site 216594014634 homodimer interface [polypeptide binding]; other site 216594014635 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 216594014636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594014637 S-adenosylmethionine binding site [chemical binding]; other site 216594014638 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 216594014639 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216594014640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594014641 catalytic residue [active] 216594014642 Uncharacterized conserved protein [Function unknown]; Region: COG4301 216594014643 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 216594014644 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 216594014645 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 216594014646 putative active site [active] 216594014647 putative dimer interface [polypeptide binding]; other site 216594014648 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 216594014649 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 216594014650 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 216594014651 PknH-like extracellular domain; Region: PknH_C; pfam14032 216594014652 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 216594014653 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 216594014654 tetramer interface [polypeptide binding]; other site 216594014655 heme binding pocket [chemical binding]; other site 216594014656 NADPH binding site [chemical binding]; other site 216594014657 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 216594014658 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 216594014659 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216594014660 aspartate kinase; Reviewed; Region: PRK06635 216594014661 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 216594014662 putative nucleotide binding site [chemical binding]; other site 216594014663 putative catalytic residues [active] 216594014664 putative Mg ion binding site [ion binding]; other site 216594014665 putative aspartate binding site [chemical binding]; other site 216594014666 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 216594014667 putative allosteric regulatory site; other site 216594014668 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 216594014669 putative allosteric regulatory residue; other site 216594014670 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216594014671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216594014672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594014673 Walker A/P-loop; other site 216594014674 ATP binding site [chemical binding]; other site 216594014675 Q-loop/lid; other site 216594014676 ABC transporter signature motif; other site 216594014677 Walker B; other site 216594014678 D-loop; other site 216594014679 H-loop/switch region; other site 216594014680 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216594014681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216594014682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216594014683 Walker A/P-loop; other site 216594014684 ATP binding site [chemical binding]; other site 216594014685 Q-loop/lid; other site 216594014686 ABC transporter signature motif; other site 216594014687 Walker B; other site 216594014688 D-loop; other site 216594014689 H-loop/switch region; other site 216594014690 2-isopropylmalate synthase; Validated; Region: PRK03739 216594014691 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 216594014692 active site 216594014693 catalytic residues [active] 216594014694 metal binding site [ion binding]; metal-binding site 216594014695 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 216594014696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 216594014697 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 216594014698 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216594014699 active site 216594014700 catalytic site [active] 216594014701 substrate binding site [chemical binding]; other site 216594014702 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 216594014703 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216594014704 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 216594014705 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 216594014706 catalytic triad [active] 216594014707 recombination protein RecR; Reviewed; Region: recR; PRK00076 216594014708 RecR protein; Region: RecR; pfam02132 216594014709 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 216594014710 putative active site [active] 216594014711 putative metal-binding site [ion binding]; other site 216594014712 tetramer interface [polypeptide binding]; other site 216594014713 hypothetical protein; Validated; Region: PRK00153 216594014714 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 216594014715 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216594014716 active site 216594014717 metal binding site [ion binding]; metal-binding site 216594014718 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 216594014719 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594014720 FAD binding domain; Region: FAD_binding_4; pfam01565 216594014721 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 216594014722 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216594014723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216594014724 S-adenosylmethionine binding site [chemical binding]; other site 216594014725 RDD family; Region: RDD; pfam06271 216594014726 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 216594014727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594014728 Walker A motif; other site 216594014729 ATP binding site [chemical binding]; other site 216594014730 Walker B motif; other site 216594014731 arginine finger; other site 216594014732 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 216594014733 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 216594014734 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594014735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594014736 catalytic residue [active] 216594014737 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216594014738 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594014739 substrate binding site [chemical binding]; other site 216594014740 oxyanion hole (OAH) forming residues; other site 216594014741 trimer interface [polypeptide binding]; other site 216594014742 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 216594014743 CHAT domain; Region: CHAT; cl17868 216594014744 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 216594014745 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216594014746 Cutinase; Region: Cutinase; pfam01083 216594014747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216594014748 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 216594014749 NAD(P) binding site [chemical binding]; other site 216594014750 active site 216594014751 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 216594014752 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 216594014753 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594014754 cyclase homology domain; Region: CHD; cd07302 216594014755 nucleotidyl binding site; other site 216594014756 metal binding site [ion binding]; metal-binding site 216594014757 dimer interface [polypeptide binding]; other site 216594014758 Predicted ATPase [General function prediction only]; Region: COG3899 216594014759 AAA ATPase domain; Region: AAA_16; pfam13191 216594014760 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 216594014761 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216594014762 Double zinc ribbon; Region: DZR; pfam12773 216594014763 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216594014764 cyclase homology domain; Region: CHD; cd07302 216594014765 nucleotidyl binding site; other site 216594014766 metal binding site [ion binding]; metal-binding site 216594014767 dimer interface [polypeptide binding]; other site 216594014768 Predicted ATPase [General function prediction only]; Region: COG3899 216594014769 AAA ATPase domain; Region: AAA_16; pfam13191 216594014770 PE family; Region: PE; pfam00934 216594014771 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594014772 PPE family; Region: PPE; pfam00823 216594014773 MURD143; Contains three hypothetical secreted proteins 216594014774 Protein of unknown function (DUF732); Region: DUF732; pfam05305 216594014775 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 216594014776 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 216594014777 nucleotide binding site [chemical binding]; other site 216594014778 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 216594014779 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 216594014780 active site 216594014781 DNA binding site [nucleotide binding] 216594014782 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 216594014783 DNA binding site [nucleotide binding] 216594014784 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216594014785 Cytochrome P450; Region: p450; cl12078 216594014786 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; pfam10092 216594014787 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 216594014788 nudix motif; other site 216594014789 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594014790 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594014791 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 216594014792 putative NAD(P) binding site [chemical binding]; other site 216594014793 active site 216594014794 putative substrate binding site [chemical binding]; other site 216594014795 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 216594014796 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594014797 putative acyl-acceptor binding pocket; other site 216594014798 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 216594014799 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216594014800 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 216594014801 acyl-activating enzyme (AAE) consensus motif; other site 216594014802 putative AMP binding site [chemical binding]; other site 216594014803 putative active site [active] 216594014804 putative CoA binding site [chemical binding]; other site 216594014805 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216594014806 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216594014807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216594014808 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594014809 PPE family; Region: PPE; pfam00823 216594014810 MURD144; Overlaps a single PPE-family protein 216594014811 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 216594014812 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 216594014813 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594014814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 216594014815 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 216594014816 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216594014817 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594014818 classical (c) SDRs; Region: SDR_c; cd05233 216594014819 NAD(P) binding site [chemical binding]; other site 216594014820 active site 216594014821 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 216594014822 dimerization interface [polypeptide binding]; other site 216594014823 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216594014824 NAD binding site [chemical binding]; other site 216594014825 ligand binding site [chemical binding]; other site 216594014826 catalytic site [active] 216594014827 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 216594014828 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216594014829 acyl-activating enzyme (AAE) consensus motif; other site 216594014830 AMP binding site [chemical binding]; other site 216594014831 active site 216594014832 CoA binding site [chemical binding]; other site 216594014833 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216594014834 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 216594014835 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216594014836 putative trimer interface [polypeptide binding]; other site 216594014837 putative CoA binding site [chemical binding]; other site 216594014838 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216594014839 putative trimer interface [polypeptide binding]; other site 216594014840 putative CoA binding site [chemical binding]; other site 216594014841 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 216594014842 Zn binding site [ion binding]; other site 216594014843 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 216594014844 PE family; Region: PE; pfam00934 216594014845 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216594014846 classical (c) SDRs; Region: SDR_c; cd05233 216594014847 NAD(P) binding site [chemical binding]; other site 216594014848 active site 216594014849 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594014850 TM2 domain; Region: TM2; pfam05154 216594014851 Uncharacterized conserved protein [Function unknown]; Region: COG0393 216594014852 PE family; Region: PE; pfam00934 216594014853 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 216594014854 nucleoside/Zn binding site; other site 216594014855 dimer interface [polypeptide binding]; other site 216594014856 catalytic motif [active] 216594014857 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 216594014858 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 216594014859 prephenate dehydrogenase; Validated; Region: PRK08507 216594014860 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 216594014861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216594014862 ABC-ATPase subunit interface; other site 216594014863 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 216594014864 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 216594014865 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 216594014866 Walker A/P-loop; other site 216594014867 ATP binding site [chemical binding]; other site 216594014868 Q-loop/lid; other site 216594014869 ABC transporter signature motif; other site 216594014870 Walker B; other site 216594014871 D-loop; other site 216594014872 H-loop/switch region; other site 216594014873 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216594014874 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 216594014875 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 216594014876 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 216594014877 putative active site [active] 216594014878 ATP binding site [chemical binding]; other site 216594014879 putative substrate binding site [chemical binding]; other site 216594014880 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594014881 catalytic core [active] 216594014882 PE family; Region: PE; pfam00934 216594014883 MURD145; Overlaps three large CDS encoding PE-PGRS family proteins 216594014884 PE family; Region: PE; pfam00934 216594014885 PE family; Region: PE; pfam00934 216594014886 Phosphotransferase enzyme family; Region: APH; pfam01636 216594014887 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 216594014888 putative active site [active] 216594014889 putative substrate binding site [chemical binding]; other site 216594014890 ATP binding site [chemical binding]; other site 216594014891 short chain dehydrogenase; Provisional; Region: PRK07035 216594014892 classical (c) SDRs; Region: SDR_c; cd05233 216594014893 NAD(P) binding site [chemical binding]; other site 216594014894 active site 216594014895 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594014896 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594014897 active site 216594014898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594014899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594014900 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216594014901 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 216594014902 NAD(P) binding site [chemical binding]; other site 216594014903 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 216594014904 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216594014905 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 216594014906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216594014907 dimer interface [polypeptide binding]; other site 216594014908 phosphorylation site [posttranslational modification] 216594014909 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 216594014910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216594014911 ATP binding site [chemical binding]; other site 216594014912 Mg2+ binding site [ion binding]; other site 216594014913 G-X-G motif; other site 216594014914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216594014915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216594014916 active site 216594014917 phosphorylation site [posttranslational modification] 216594014918 intermolecular recognition site; other site 216594014919 dimerization interface [polypeptide binding]; other site 216594014920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216594014921 DNA binding site [nucleotide binding] 216594014922 Protein of unknown function (DUF419); Region: DUF419; cl15265 216594014923 PE family; Region: PE; pfam00934 216594014924 PE family; Region: PE; pfam00934 216594014925 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 216594014926 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 216594014927 SnoaL-like domain; Region: SnoaL_2; pfam12680 216594014928 Phosphotransferase enzyme family; Region: APH; pfam01636 216594014929 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 216594014930 putative active site [active] 216594014931 putative substrate binding site [chemical binding]; other site 216594014932 ATP binding site [chemical binding]; other site 216594014933 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 216594014934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216594014935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216594014936 homodimer interface [polypeptide binding]; other site 216594014937 catalytic residue [active] 216594014938 GXWXG protein; Region: GXWXG; pfam14231 216594014939 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 216594014940 TIGR03086 family protein; Region: TIGR03086 216594014941 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 216594014942 enoyl-CoA hydratase; Provisional; Region: PRK06142 216594014943 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216594014944 substrate binding site [chemical binding]; other site 216594014945 oxyanion hole (OAH) forming residues; other site 216594014946 trimer interface [polypeptide binding]; other site 216594014947 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216594014948 Beta-lactamase; Region: Beta-lactamase; pfam00144 216594014949 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594014950 PPE family; Region: PPE; pfam00823 216594014951 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594014952 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 216594014953 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 216594014954 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 216594014955 NAD(P) binding site [chemical binding]; other site 216594014956 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216594014957 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216594014958 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216594014959 catalytic residue [active] 216594014960 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 216594014961 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 216594014962 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 216594014963 Walker A/P-loop; other site 216594014964 ATP binding site [chemical binding]; other site 216594014965 Q-loop/lid; other site 216594014966 ABC transporter signature motif; other site 216594014967 Walker B; other site 216594014968 D-loop; other site 216594014969 H-loop/switch region; other site 216594014970 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216594014971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216594014972 active site 216594014973 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 216594014974 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216594014975 MURD146; Contains a single PE-PGRS family protein 216594014976 PE family; Region: PE; pfam00934 216594014977 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216594014978 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216594014979 hydrophobic ligand binding site; other site 216594014980 PE family; Region: PE; pfam00934 216594014981 MURD147; OVerlaps a single PE-PGRS family protein 216594014982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216594014983 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 216594014984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216594014985 dimerization interface [polypeptide binding]; other site 216594014986 putative DNA binding site [nucleotide binding]; other site 216594014987 putative Zn2+ binding site [ion binding]; other site 216594014988 PE family; Region: PE; pfam00934 216594014989 MURD148; Overlaps a single PE-PGRS family protein 216594014990 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 216594014991 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216594014992 active site 216594014993 MURD149; Contains a hypothetical dehydratase 216594014994 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 216594014995 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 216594014996 NAD binding site [chemical binding]; other site 216594014997 substrate binding site [chemical binding]; other site 216594014998 active site 216594014999 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216594015000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216594015001 active site 216594015002 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216594015003 Peptidase family M23; Region: Peptidase_M23; pfam01551 216594015004 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 216594015005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 216594015006 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 216594015007 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 216594015008 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216594015009 Predicted membrane protein [Function unknown]; Region: COG2246 216594015010 GtrA-like protein; Region: GtrA; pfam04138 216594015011 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216594015012 FAD binding domain; Region: FAD_binding_4; pfam01565 216594015013 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 216594015014 short chain dehydrogenase; Provisional; Region: PRK07904 216594015015 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216594015016 NAD(P) binding site [chemical binding]; other site 216594015017 active site 216594015018 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 216594015019 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 216594015020 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 216594015021 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 216594015022 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 216594015023 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 216594015024 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216594015025 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216594015026 active site 216594015027 PE family; Region: PE; pfam00934 216594015028 MURD150; Overlaps the C-term of a large PE-PGRS family protein 216594015029 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216594015030 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216594015031 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216594015032 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594015033 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216594015034 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 216594015035 active site 216594015036 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216594015037 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216594015038 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 216594015039 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 216594015040 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 216594015041 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216594015042 acyl-activating enzyme (AAE) consensus motif; other site 216594015043 active site 216594015044 Cutinase; Region: Cutinase; pfam01083 216594015045 Predicted esterase [General function prediction only]; Region: COG0627 216594015046 Putative esterase; Region: Esterase; pfam00756 216594015047 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 216594015048 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216594015049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216594015050 active site 216594015051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216594015052 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 216594015053 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594015054 UDP-galactopyranose mutase; Region: GLF; pfam03275 216594015055 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 216594015056 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 216594015057 substrate binding site [chemical binding]; other site 216594015058 amidase catalytic site [active] 216594015059 Zn binding residues [ion binding]; other site 216594015060 LGFP repeat; Region: LGFP; pfam08310 216594015061 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 216594015062 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216594015063 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594015064 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216594015065 putative acyl-acceptor binding pocket; other site 216594015066 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594015067 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216594015068 putative acyl-acceptor binding pocket; other site 216594015069 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216594015070 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216594015071 putative acyl-acceptor binding pocket; other site 216594015072 Phosphotransferase enzyme family; Region: APH; pfam01636 216594015073 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 216594015074 active site 216594015075 ATP binding site [chemical binding]; other site 216594015076 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216594015077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216594015078 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 216594015079 iron-sulfur cluster [ion binding]; other site 216594015080 [2Fe-2S] cluster binding site [ion binding]; other site 216594015081 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 216594015082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594015083 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 216594015084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594015085 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 216594015086 seryl-tRNA synthetase; Provisional; Region: PRK05431 216594015087 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 216594015088 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 216594015089 dimer interface [polypeptide binding]; other site 216594015090 active site 216594015091 motif 1; other site 216594015092 motif 2; other site 216594015093 motif 3; other site 216594015094 Septum formation; Region: Septum_form; pfam13845 216594015095 Septum formation; Region: Septum_form; pfam13845 216594015096 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 216594015097 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216594015098 catalytic core [active] 216594015099 prephenate dehydratase; Provisional; Region: PRK11898 216594015100 Prephenate dehydratase; Region: PDT; pfam00800 216594015101 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 216594015102 putative L-Phe binding site [chemical binding]; other site 216594015103 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 216594015104 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 216594015105 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 216594015106 Ferritin-like domain; Region: Ferritin; pfam00210 216594015107 ferroxidase diiron center [ion binding]; other site 216594015108 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 216594015109 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 216594015110 putative active site [active] 216594015111 catalytic site [active] 216594015112 putative metal binding site [ion binding]; other site 216594015113 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 216594015114 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 216594015115 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 216594015116 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 216594015117 Predicted membrane protein [Function unknown]; Region: COG2119 216594015118 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 216594015119 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 216594015120 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216594015121 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 216594015122 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216594015123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594015124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216594015125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216594015126 DNA polymerase IV; Validated; Region: PRK03858 216594015127 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 216594015128 active site 216594015129 DNA binding site [nucleotide binding] 216594015130 hypothetical protein; Provisional; Region: PRK07945 216594015131 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 216594015132 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 216594015133 active site 216594015134 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 216594015135 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594015136 Ligand Binding Site [chemical binding]; other site 216594015137 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216594015138 Ligand Binding Site [chemical binding]; other site 216594015139 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 216594015140 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216594015141 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 216594015142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216594015143 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 216594015144 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 216594015145 active site 216594015146 dimer interface [polypeptide binding]; other site 216594015147 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 216594015148 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 216594015149 active site 216594015150 FMN binding site [chemical binding]; other site 216594015151 substrate binding site [chemical binding]; other site 216594015152 3Fe-4S cluster binding site [ion binding]; other site 216594015153 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 216594015154 domain interface; other site 216594015155 MURD151; This region contains 11 paralogous hypothetical transmembrane proteins - function unknown. They are not present in M. tuberculosis, M. leprae, M. avium paratuberculosis or M. smegmatis 216594015156 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594015157 PPE family; Region: PPE; pfam00823 216594015158 Potato leaf roll virus readthrough protein; Region: PLRV_ORF5; pfam01690 216594015159 Proteins of 100 residues with WXG; Region: WXG100; cl02005 216594015160 Domain of unknown function (DUF373); Region: DUF373; cl12079 216594015161 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 216594015162 ESX-1 216594015163 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 216594015164 FHA domain; Region: FHA; pfam00498 216594015165 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 216594015166 EspG family; Region: ESX-1_EspG; pfam14011 216594015167 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 216594015168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216594015169 Walker A motif; other site 216594015170 ATP binding site [chemical binding]; other site 216594015171 Walker B motif; other site 216594015172 arginine finger; other site 216594015173 Protein of unknown function (DUF690); Region: DUF690; pfam05108 216594015174 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 216594015175 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594015176 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 216594015177 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594015178 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216594015179 MURD152; This is the region orthologous to RD1 in M. tuberculosis and includes ESAT-6 and CFP-10 216594015180 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 216594015181 PPE family; Region: PPE; pfam00823 216594015182 Proteins of 100 residues with WXG; Region: WXG100; cl02005 216594015183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 216594015184 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 216594015185 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 216594015186 MURD153; function Unknown but contains a putative proteolytic enzyme, membrane proteins and conserved hypothetical alanine-rich proteins 216594015187 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 216594015188 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 216594015189 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 216594015190 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 216594015191 active site 216594015192 catalytic residues [active] 216594015193 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 216594015194 catalytic residue [active] 216594015195 MURD154; function Unknown but contains a conserved hypothetical alanine and proline-rich protein 216594015196 Hemerythrin family; Region: Hemerythrin-like; cl15774 216594015197 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 216594015198 active site 216594015199 conformational flexibility of ligand binding pocket; other site 216594015200 ADP-ribosylating toxin turn-turn motif; other site 216594015201 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 216594015202 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 216594015203 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 216594015204 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 216594015205 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 216594015206 active site 216594015207 NTP binding site [chemical binding]; other site 216594015208 metal binding triad [ion binding]; metal-binding site 216594015209 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 216594015210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216594015211 Zn2+ binding site [ion binding]; other site 216594015212 Mg2+ binding site [ion binding]; other site 216594015213 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 216594015214 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 216594015215 active site 216594015216 Ap6A binding site [chemical binding]; other site 216594015217 nudix motif; other site 216594015218 metal binding site [ion binding]; metal-binding site 216594015219 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 216594015220 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 216594015221 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216594015222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216594015223 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216594015224 DNA binding residues [nucleotide binding] 216594015225 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 216594015226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216594015227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216594015228 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216594015229 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216594015230 catalytic residues [active] 216594015231 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 216594015232 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216594015233 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216594015234 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 216594015235 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216594015236 active site 216594015237 metal binding site [ion binding]; metal-binding site 216594015238 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 216594015239 ParB-like nuclease domain; Region: ParB; smart00470 216594015240 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216594015241 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216594015242 P-loop; other site 216594015243 Magnesium ion binding site [ion binding]; other site 216594015244 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216594015245 Magnesium ion binding site [ion binding]; other site 216594015246 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 216594015247 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 216594015248 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 216594015249 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 216594015250 G-X-X-G motif; other site 216594015251 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 216594015252 RxxxH motif; other site 216594015253 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 216594015254 hypothetical protein; Validated; Region: PRK00041 216594015255 ribonuclease P; Reviewed; Region: rnpA; PRK00588 216594015256 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399