-- dump date 20140619_153116 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 216594000001 SEQ_END SEQ_END NC_010604.1 23317 23317 DR NC_010604.1; contig end 23317..23317 Mycobacterium marinum M 216594000002 SEQ_END SEQ_END NC_010612.1 6636827 6636827 DR NC_010612.1; contig end 6636827..6636827 Mycobacterium marinum M YP_001840829.1 CDS repA NC_010604.1 241 1317 D replication protein, repA 241..1317 Mycobacterium marinum M 6229865 YP_001840830.1 CDS MMAR_p03 NC_010604.1 1634 4966 D similar to AA sequence INSD:AY056023; ATP-dependent exoDNAse (exonuclease V) 1634..4966 Mycobacterium marinum M 6229848 YP_001840831.1 CDS MMAR_p04 NC_010604.1 4978 5739 R hypothetical protein complement(4978..5739) Mycobacterium marinum M 6229854 YP_001840832.1 CDS MMAR_p05 NC_010604.1 5736 8180 R hypothetical protein complement(5736..8180) Mycobacterium marinum M 6229853 YP_001840833.1 CDS MMAR_p06 NC_010604.1 8180 8707 R hypothetical protein complement(8180..8707) Mycobacterium marinum M 6229856 YP_001840834.1 CDS MMAR_p07 NC_010604.1 8874 9464 R hypothetical protein complement(8874..9464) Mycobacterium marinum M 6229871 YP_001840835.1 CDS MMAR_p08 NC_010604.1 9522 10106 R site-specific DNA recombinase complement(9522..10106) Mycobacterium marinum M 6229873 YP_001840836.1 CDS MMAR_p09 NC_010604.1 10305 11657 R pyridine nucleotide-disulfide oxidoreductase complement(10305..11657) Mycobacterium marinum M 6229860 YP_001840837.1 CDS merB NC_010604.1 11654 12310 R cleaves the carbon-mercury bond of organomercuric compounds; alkylmercury lyase complement(11654..12310) Mycobacterium marinum M 6229850 YP_001840838.1 CDS merH NC_010604.1 12357 12872 R Contains four transmembrane domains.; mercuric transporter MerH complement(12357..12872) Mycobacterium marinum M 6229852 YP_001840839.1 CDS merA NC_010604.1 12901 14319 R mercuric reductase, MerA complement(12901..14319) Mycobacterium marinum M 6229859 YP_001840840.1 CDS MMAR_p13 NC_010604.1 14458 14841 D Proposed that MerR binds to inverted repeat and represses transcription of merA in the absence of mercuric ions and negatively regulates its own expression in the presence of mercuric ions.; transcriptional repressor protein, MerR 14458..14841 Mycobacterium marinum M 6229869 YP_001840841.1 CDS merT NC_010604.1 14841 15275 D mercuric transport protein, MerT 14841..15275 Mycobacterium marinum M 6229872 YP_001840842.1 CDS MMAR_p15 NC_010604.1 15272 15868 D site-specific DNA recombinase 15272..15868 Mycobacterium marinum M 6229847 YP_001840843.1 CDS MMAR_p16 NC_010604.1 15865 16044 D hypothetical protein 15865..16044 Mycobacterium marinum M 6229870 YP_001840844.1 CDS MMAR_p17 NC_010604.1 16052 16195 D hypothetical protein 16052..16195 Mycobacterium marinum M 6229855 YP_001840845.1 CDS MMAR_p18 NC_010604.1 16219 16515 R hypothetical protein complement(16219..16515) Mycobacterium marinum M 6229849 YP_001840846.1 CDS MMAR_p19 NC_010604.1 16515 16748 R hypothetical protein complement(16515..16748) Mycobacterium marinum M 6229863 YP_001840847.1 CDS MMAR_p20 NC_010604.1 16837 17277 R hypothetical protein complement(16837..17277) Mycobacterium marinum M 6229862 YP_001840848.1 CDS MMAR_p21 NC_010604.1 17274 18095 R Fis family transcriptional regulator complement(17274..18095) Mycobacterium marinum M 6229851 YP_001840849.1 CDS MMAR_p22 NC_010604.1 18462 19307 D hypothetical protein 18462..19307 Mycobacterium marinum M 6229866 YP_001840850.1 CDS parA NC_010604.1 19405 20235 D chromosome partitioning protein, ParA 19405..20235 Mycobacterium marinum M 6229861 YP_001840851.1 CDS MMAR_p24 NC_010604.1 20232 20624 D hypothetical protein 20232..20624 Mycobacterium marinum M 6229868 YP_001840852.1 CDS MMAR_p25 NC_010604.1 21101 21307 D contains two transmembrane domains and a potential signal peptide sequence; hypothetical protein 21101..21307 Mycobacterium marinum M 6229874 YP_001840853.1 CDS MMAR_p27 NC_010604.1 21510 21737 R hypothetical protein complement(21510..21737) Mycobacterium marinum M 6229867 YP_001840854.1 CDS MMAR_p30 NC_010604.1 21820 22098 D hypothetical protein 21820..22098 Mycobacterium marinum M 6229846 YP_001840855.1 CDS MMAR_p31 NC_010604.1 22110 22430 D hypothetical protein 22110..22430 Mycobacterium marinum M 6229864 YP_001840856.1 CDS MMAR_p32 NC_010604.1 22453 22839 R hypothetical protein complement(22453..22839) Mycobacterium marinum M 6229857 YP_001840857.1 CDS MMAR_p33 NC_010604.1 22833 23135 R hypothetical protein complement(22833..23135) Mycobacterium marinum M 6229858 YP_001848327.1 CDS dnaA NC_010612.1 1 1533 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1533 Mycobacterium marinum M 6229632 YP_001848328.1 CDS dnaN NC_010612.1 2074 3282 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2074..3282 Mycobacterium marinum M 6224526 YP_001848329.1 CDS recF NC_010612.1 3303 4460 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3303..4460 Mycobacterium marinum M 6224527 YP_001848330.1 CDS MMAR_0004 NC_010612.1 4457 5020 D hypothetical protein 4457..5020 Mycobacterium marinum M 6224528 YP_001848331.1 CDS gyrB NC_010612.1 5230 7308 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 5230..7308 Mycobacterium marinum M 6224529 YP_001848332.1 CDS gyrA NC_010612.1 7348 9867 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 7348..9867 Mycobacterium marinum M 6224530 YP_001848333.1 CDS MMAR_0007 NC_010612.1 9951 10853 D hypothetical protein 9951..10853 Mycobacterium marinum M 6224531 YP_001848334.1 CDS MMAR_0008 NC_010612.1 11363 12199 D hypothetical protein 11363..12199 Mycobacterium marinum M 6224534 YP_001848335.1 CDS MMAR_0009 NC_010612.1 12227 12988 R transcription; transcriptional regulator complement(12227..12988) Mycobacterium marinum M 6224535 YP_001848336.1 CDS MMAR_0010 NC_010612.1 13099 13527 R hypothetical protein complement(13099..13527) Mycobacterium marinum M 6224536 YP_001848337.1 CDS ppiA NC_010612.1 13692 14240 D ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides]; peptidyl-prolyl cis-trans isomerase A, PpiA 13692..14240 Mycobacterium marinum M 6224537 YP_001848338.1 CDS MMAR_0012 NC_010612.1 14251 14676 R hypothetical protein complement(14251..14676) Mycobacterium marinum M 6224538 YP_001848339.1 CDS MMAR_0013 NC_010612.1 14832 15113 R integral membrane protein involved in inhibition of the Z-ring formation; putative septation inhibitor protein complement(14832..15113) Mycobacterium marinum M 6224539 YP_001848340.1 CDS MMAR_0014 NC_010612.1 15242 15985 D hypothetical protein 15242..15985 Mycobacterium marinum M 6224540 YP_001848341.1 CDS trpG NC_010612.1 16023 16709 D aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 16023..16709 Mycobacterium marinum M 6224541 YP_001848342.1 CDS pknB NC_010612.1 16687 18567 R involved in signal transduction (via phosphorylation). thought to regulate cell division/differentiation. can phosphorylate the peptide substrate myelin basic protein (MBP) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase B PknB complement(16687..18567) Mycobacterium marinum M 6224542 YP_001848343.1 CDS pknA NC_010612.1 18564 19922 R involved in signal transduction (via phosphorylation). thought to regulate morphological changes associated with cell division/differentiation process. phosphorylates at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase a PknA complement(18564..19922) Mycobacterium marinum M 6224543 YP_001848344.1 CDS pbpA NC_010612.1 19919 21394 R involved in peptidoglycan synthesis (at the final stages). cell wall formation; PbpA is supposed to be responsible for the determination of the rod shape of the cell. its synthesizes cross-linked peptidoglycan from lipid intermediates; penicillin-binding protein PbpA complement(19919..21394) Mycobacterium marinum M 6224544 YP_001848345.1 CDS rodA NC_010612.1 21391 22800 R this is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. plays a role in the stabilization of the FtsZ ring during cell division; cell division protein RodA complement(21391..22800) Mycobacterium marinum M 6224545 YP_001848346.1 CDS pstP NC_010612.1 22797 24356 R involved in regulation (using dephosphorylation of a specific phosphorylated substrate); serine/threonine phosphatase PstP complement(22797..24356) Mycobacterium marinum M 6224546 YP_001848347.1 CDS MMAR_0021 NC_010612.1 24353 24820 R hypothetical protein complement(24353..24820) Mycobacterium marinum M 6224547 YP_001848348.1 CDS MMAR_0022 NC_010612.1 24954 26594 R function unknown, contains FHA domain; hypothetical protein complement(24954..26594) Mycobacterium marinum M 6224548 YP_001848349.1 CDS MMAR_0023 NC_010612.1 27392 27772 D some domain conservation with a putative killer suppression protein HigA, from Methylococcus capsulatus str. Bath; killer suppression protein 27392..27772 Mycobacterium marinum M 6224550 YP_001848350.1 CDS MMAR_0024 NC_010612.1 27769 28845 D antidote for potential plasmid segregant killing system. maybe the partner for the toxin encoded by the upstream gene; plasmid maintenance system antidote protein 27769..28845 Mycobacterium marinum M 6224551 YP_001848351.1 CDS MMAR_0025 NC_010612.1 28826 29764 R hypothetical protein complement(28826..29764) Mycobacterium marinum M 6224552 YP_001848352.1 CDS MMAR_0026 NC_010612.1 29745 30536 R hypothetical protein complement(29745..30536) Mycobacterium marinum M 6224553 YP_001848353.1 CDS thyA_1 NC_010612.1 30550 31500 R involved in deoxyribonucleotide biosynthesis. provides the sole de novo source of dTMP for dana biosynthesis [catalytic activity: 5,10- methylenetetrahydrofolate + dump = dihydrofolate + dTMP]; thymidylate synthase, ThyA complement(30550..31500) Mycobacterium marinum M 6224554 YP_001848354.1 CDS MMAR_0028 NC_010612.1 31578 31934 R hypothetical protein complement(31578..31934) Mycobacterium marinum M 6224555 YP_001848355.1 CDS MMAR_0029 NC_010612.1 31934 32410 R hypothetical protein complement(31934..32410) Mycobacterium marinum M 6224556 YP_001848356.1 CDS MMAR_0030 NC_010612.1 33374 34174 R short-chain dehydrogenase complement(33374..34174) Mycobacterium marinum M 6224557 YP_001848357.1 CDS MMAR_0031 NC_010612.1 34328 35080 D hypothetical protein 34328..35080 Mycobacterium marinum M 6224558 YP_001848358.1 CDS MMAR_0032 NC_010612.1 35105 36100 R hypothetical protein complement(35105..36100) Mycobacterium marinum M 6224559 YP_001848359.1 CDS MMAR_0033 NC_010612.1 36106 36915 R hypothetical protein complement(36106..36915) Mycobacterium marinum M 6224251 YP_001848360.1 CDS proV_1 NC_010612.1 36912 38111 R thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for energy coupling to the transport system; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV complement(36912..38111) Mycobacterium marinum M 6224252 YP_001848361.1 CDS MMAR_0035 NC_010612.1 38104 38772 R maybe involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane; ABC transporter permease complement(38104..38772) Mycobacterium marinum M 6224253 YP_001848362.1 CDS MMAR_0036 NC_010612.1 39071 39478 D DNA-binding protein 39071..39478 Mycobacterium marinum M 6224254 YP_001848363.1 CDS MMAR_0037 NC_010612.1 39580 40539 R hypothetical protein complement(39580..40539) Mycobacterium marinum M 6224255 YP_001848364.1 CDS amt_1 NC_010612.1 40669 41982 D thought to be involved in transport of ammonium across the membrane (export). responsible for the translocation of the substrate across the membrane; ammonium-transport integral membrane protein, Amt 40669..41982 Mycobacterium marinum M 6224256 YP_001848365.1 CDS MMAR_0039 NC_010612.1 41992 42291 R hypothetical protein complement(41992..42291) Mycobacterium marinum M 6224257 YP_001848366.1 CDS MMAR_0040 NC_010612.1 42288 43256 R N-term truncated by frame-shift mutation; hypothetical protein complement(42288..43256) Mycobacterium marinum M 6224258 YP_001848367.1 CDS whiB5 NC_010612.1 43370 43786 R involved in transcriptional mechanism; transcriptional regulatory protein (Whib-like), WhiB5 complement(43370..43786) Mycobacterium marinum M 6224259 YP_001848368.1 CDS MMAR_0042 NC_010612.1 43930 44721 D maybe involved in transcriptional mechanism; transcriptional regulatory protein 43930..44721 Mycobacterium marinum M 6224260 YP_001848369.1 CDS MMAR_0043 NC_010612.1 44718 45545 D function unknown. the P60 protein is a major extracellular protein may be involved in the invasion of host cells; secreted protein P60-related protein 44718..45545 Mycobacterium marinum M 6224261 YP_001848370.1 CDS MMAR_0044 NC_010612.1 45542 45922 D hypothetical protein 45542..45922 Mycobacterium marinum M 6224262 YP_001848371.1 CDS MMAR_0045 NC_010612.1 45997 47250 D hypothetical protein 45997..47250 Mycobacterium marinum M 6224263 YP_001848372.1 CDS MMAR_0046 NC_010612.1 47293 47610 D hypothetical protein 47293..47610 Mycobacterium marinum M 6224264 YP_001848373.1 CDS MMAR_0047 NC_010612.1 47607 47912 D hypothetical protein 47607..47912 Mycobacterium marinum M 6224265 YP_001848374.1 CDS MMAR_0048 NC_010612.1 48140 49246 D hypothetical protein 48140..49246 Mycobacterium marinum M 6224266 YP_001848375.1 CDS MMAR_0049 NC_010612.1 49334 49654 D hypothetical protein 49334..49654 Mycobacterium marinum M 6224267 YP_001848376.1 CDS MMAR_0050 NC_010612.1 49704 50027 D hypothetical protein 49704..50027 Mycobacterium marinum M 6224268 YP_001848377.1 CDS MMAR_0051 NC_010612.1 50055 50828 R hypothetical protein complement(50055..50828) Mycobacterium marinum M 6224269 YP_001848378.1 CDS MMAR_0052 NC_010612.1 50831 52123 R integral membrane protein complement(50831..52123) Mycobacterium marinum M 6224270 YP_001848379.1 CDS MMAR_0053 NC_010612.1 52283 52888 D hypothetical protein 52283..52888 Mycobacterium marinum M 6224271 YP_001848380.1 CDS MMAR_0054 NC_010612.1 52875 53882 R hypothetical protein complement(52875..53882) Mycobacterium marinum M 6224272 YP_001848381.1 CDS MMAR_0055 NC_010612.1 53923 54273 R hypothetical protein complement(53923..54273) Mycobacterium marinum M 6224273 YP_001848382.1 CDS mtc28 NC_010612.1 54358 55491 R secreted proline rich protein Mtc28 complement(54358..55491) Mycobacterium marinum M 6224274 YP_001848383.1 CDS leuS NC_010612.1 55690 58620 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 55690..58620 Mycobacterium marinum M 6224275 YP_001848384.1 CDS MMAR_0058 NC_010612.1 58650 59315 R function unknown, possibly involved in cellular metabolism; short chain dehydrogenase complement(58650..59315) Mycobacterium marinum M 6224276 YP_001848385.1 CDS MMAR_0059 NC_010612.1 59356 59859 R possibly involved in transcriptional mechanism; transcriptional regulatory protein complement(59356..59859) Mycobacterium marinum M 6224277 YP_001848386.1 CDS MMAR_0060 NC_010612.1 59916 60665 R involved in amino acid transport and metabolism; glutamine ABC transporter ATP-binding protein complement(59916..60665) Mycobacterium marinum M 6224278 YP_001848387.1 CDS glnQ NC_010612.1 60662 62431 R amino acid transport and metabolism; ABC transporter permease GlnQ complement(60662..62431) Mycobacterium marinum M 6224279 YP_001848388.1 CDS MMAR_0062 NC_010612.1 62513 63277 R involved in transcriptional mechanism; GntR family transcriptional regulator complement(62513..63277) Mycobacterium marinum M 6224280 YP_001848389.1 CDS MMAR_0063 NC_010612.1 63388 64185 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(63388..64185) Mycobacterium marinum M 6224281 YP_001848390.1 CDS MMAR_0064 NC_010612.1 64217 65131 R function unknown, probably involved in lipid biosynthesis; hydrolase complement(64217..65131) Mycobacterium marinum M 6224282 YP_001848391.1 CDS ino1 NC_010612.1 65222 66340 R involved in phosphatidylinositol (pi) biosynthetic pathway [catalytic activity: d-glucose 6-phosphate = 1L- myo-inositol 1-phosphate]; myo-inositol-1-phosphate synthase Ino1 complement(65222..66340) Mycobacterium marinum M 6224283 YP_001848392.1 CDS MMAR_0066 NC_010612.1 66402 66944 R hypothetical protein complement(66402..66944) Mycobacterium marinum M 6224284 YP_001848393.1 CDS MMAR_0067 NC_010612.1 67100 67969 R hypothetical protein complement(67100..67969) Mycobacterium marinum M 6224285 YP_001848394.1 CDS MMAR_0068 NC_010612.1 68082 68516 D hypothetical protein 68082..68516 Mycobacterium marinum M 6224286 YP_001848395.1 CDS ponA1 NC_010612.1 68974 71046 D involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits); bifunctional penicillin-binding protein 1A/1B PonA1 68974..71046 Mycobacterium marinum M 6224287 YP_001848396.1 CDS MMAR_0070 NC_010612.1 71043 72683 D hypothetical protein 71043..72683 Mycobacterium marinum M 6224288 YP_001848397.1 CDS MMAR_0071 NC_010612.1 72683 73321 D transcriptional regulatory protein 72683..73321 Mycobacterium marinum M 6224289 YP_001848398.1 CDS rpsF NC_010612.1 73445 73735 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 73445..73735 Mycobacterium marinum M 6224290 YP_001848399.1 CDS ssb NC_010612.1 73827 74354 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 73827..74354 Mycobacterium marinum M 6224291 YP_001848400.1 CDS rpsR NC_010612.1 74400 74654 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 74400..74654 Mycobacterium marinum M 6224292 YP_001848401.1 CDS rplI NC_010612.1 74697 75155 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 74697..75155 Mycobacterium marinum M 6224293 YP_001848402.1 CDS dnaB NC_010612.1 75689 77071 D participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity; replicative DNA helicase DnaB 75689..77071 Mycobacterium marinum M 6224294 YP_001848403.1 CDS MMAR_0077 NC_010612.1 77176 77604 D hypothetical protein 77176..77604 Mycobacterium marinum M 6224295 YP_001848404.1 CDS MMAR_0078 NC_010612.1 77847 78095 D hypothetical protein 77847..78095 Mycobacterium marinum M 6224296 YP_001848405.1 CDS MMAR_0079 NC_010612.1 78147 78350 D hypothetical protein 78147..78350 Mycobacterium marinum M 6224297 YP_001848406.1 CDS coxL_2 NC_010612.1 78908 81016 R involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase large chain CoxL_2 complement(78908..81016) Mycobacterium marinum M 6224298 YP_001848407.1 CDS coxM_2 NC_010612.1 81013 82017 R function unknown; probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase medium chain CoxM_2 complement(81013..82017) Mycobacterium marinum M 6224299 YP_001848408.1 CDS coxS_2 NC_010612.1 82014 82523 R involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase small chain CoxS_2 complement(82014..82523) Mycobacterium marinum M 6224300 YP_001848409.1 CDS MMAR_0083 NC_010612.1 82520 83431 R amidohydrolase complement(82520..83431) Mycobacterium marinum M 6224301 YP_001848410.1 CDS MMAR_0084 NC_010612.1 84174 84782 D function unknown; probably involved in cellular metabolism; short chain dehydrogenase 84174..84782 Mycobacterium marinum M 6224302 YP_001848411.1 CDS MMAR_0085 NC_010612.1 84893 87637 D contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription; transcriptional regulatory protein 84893..87637 Mycobacterium marinum M 6224303 YP_001848412.1 CDS MMAR_0086 NC_010612.1 88106 88885 R function unknown, possibly involved in cellular metabolism; hydrolase complement(88106..88885) Mycobacterium marinum M 6224304 YP_001848413.1 CDS MMAR_0087 NC_010612.1 88976 90742 D Contains a non-ribosomal peptide synthetase-like condensation domain; hypothetical protein 88976..90742 Mycobacterium marinum M 6224305 YP_001848414.1 CDS MMAR_0088 NC_010612.1 90890 91492 R transcriptional regulator complement(90890..91492) Mycobacterium marinum M 6224306 YP_001848415.1 CDS MMAR_0089 NC_010612.1 91634 92122 D function unknown; contains thiopurine S- methyltransferase domain. this is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds; hypothetical protein 91634..92122 Mycobacterium marinum M 6224307 YP_001848416.1 CDS MMAR_0090 NC_010612.1 92022 92816 R transposition of the insertion sequence, ISMyma01; transposase, ISMyma01_aa2 complement(92022..92816) Mycobacterium marinum M 6224308 YP_001848417.1 CDS MMAR_0091 NC_010612.1 92858 93139 R transposition of the insertion sequence, ISMyma01; transposase, ISMyma01_aa1 complement(92858..93139) Mycobacterium marinum M 6224309 YP_001848418.1 CDS MMAR_0092 NC_010612.1 93232 93537 D hypothetical protein 93232..93537 Mycobacterium marinum M 6224310 YP_001848419.1 CDS ermB NC_010612.1 93566 95239 R translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane efflux protein ErmB complement(93566..95239) Mycobacterium marinum M 6224311 YP_001848420.1 CDS mmpL5_3 NC_010612.1 95329 98193 R thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(95329..98193) Mycobacterium marinum M 6224312 YP_001848421.1 CDS mmpS5_3 NC_010612.1 98190 98627 R membrane protein MmpS5_3 complement(98190..98627) Mycobacterium marinum M 6224313 YP_001848422.1 CDS MMAR_0096 NC_010612.1 99141 99527 D hypothetical protein 99141..99527 Mycobacterium marinum M 6224314 YP_001848423.1 CDS MMAR_0097 NC_010612.1 99527 99763 D function unknown; many of the members of this family are found in known antibiotic synthesis gene clusters; MbtH-like protein 99527..99763 Mycobacterium marinum M 6224315 YP_001848424.1 CDS MMAR_0098 NC_010612.1 99926 103084 D polyketide synthase possibly involved in lipid synthesis; polyketide synthase 99926..103084 Mycobacterium marinum M 6224316 YP_001848425.1 CDS MMAR_0099 NC_010612.1 103081 114750 D function unknown but the gene encodes a Nrp of three functional domains with the predicted sequential condensation of the amino acids threonine, threonine and alanine. the second domain contains an epimerization domain and the third domains contains a terminal te; non-ribosomal peptide synthetase 103081..114750 Mycobacterium marinum M 6224317 YP_001848426.1 CDS MMAR_0100 NC_010612.1 114798 115397 D 4-hydroxybenzoate synthetase 114798..115397 Mycobacterium marinum M 6224318 YP_001848427.1 CDS MMAR_0101 NC_010612.1 115545 122879 D function unknown but contains a single extension module with domain structure (KS, Ata, DH, KR, ACP); polyketide synthase 115545..122879 Mycobacterium marinum M 6224319 YP_001848428.1 CDS MMAR_0102 NC_010612.1 122876 129469 D function unknown but contains a single extension module with domain structure (KS, ATP, DH, ER, ACP); polyketide synthase 122876..129469 Mycobacterium marinum M 6224320 YP_001848429.1 CDS MMAR_0103 NC_010612.1 129487 130578 D hypothetical protein 129487..130578 Mycobacterium marinum M 6224321 YP_001848430.1 CDS MMAR_0104 NC_010612.1 130639 132027 D function unknown but probable role in the production of unknown PKS/NRP metabolite from this locus. amino acid homology suggests this gene product may have fatty acid ligase activity; hypothetical protein 130639..132027 Mycobacterium marinum M 6224322 YP_001848431.1 CDS MMAR_0105 NC_010612.1 132134 132397 R hypothetical protein complement(132134..132397) Mycobacterium marinum M 6224323 YP_001848432.1 CDS MMAR_0106 NC_010612.1 132604 133635 R contains two MaoC acyl dehydratase domains; hypothetical protein complement(132604..133635) Mycobacterium marinum M 6224324 YP_001848433.1 CDS celA NC_010612.1 133857 134909 D hydrolysis of cellobiose; cellobiohydrolase a (1,4-beta-cellobiosidase a) CelA 133857..134909 Mycobacterium marinum M 6224325 YP_001848434.1 CDS MMAR_0108 NC_010612.1 135051 135656 D involved in transcriptional mechanism; transcriptional regulatory protein 135051..135656 Mycobacterium marinum M 6224326 YP_001848435.1 CDS MMAR_0109 NC_010612.1 135771 136856 D hypothetical protein 135771..136856 Mycobacterium marinum M 6224327 YP_001848436.1 CDS MMAR_0110 NC_010612.1 137017 138456 D function unknown; probably involved in cellular metabolism; oxidoreductase 137017..138456 Mycobacterium marinum M 6224328 YP_001848437.1 CDS MMAR_0111 NC_010612.1 138493 139467 R PE family protein complement(138493..139467) Mycobacterium marinum M 6224329 YP_001848438.1 CDS dhaA_1 NC_010612.1 139721 140698 D catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 139721..140698 Mycobacterium marinum M 6224330 YP_001848439.1 CDS MMAR_0113 NC_010612.1 140862 141167 R hypothetical protein complement(140862..141167) Mycobacterium marinum M 6224331 YP_001848440.1 CDS MMAR_0115 NC_010612.1 141538 141798 R hypothetical protein complement(141538..141798) Mycobacterium marinum M 6224332 YP_001848441.1 CDS MMAR_0116 NC_010612.1 141795 142814 R hypothetical protein complement(141795..142814) Mycobacterium marinum M 6224333 YP_001848442.1 CDS MMAR_0117 NC_010612.1 142815 143285 R hypothetical protein complement(142815..143285) Mycobacterium marinum M 6224334 YP_001848443.1 CDS MMAR_0118 NC_010612.1 143631 144206 R regulatory protein complement(143631..144206) Mycobacterium marinum M 6224335 YP_001848444.1 CDS MMAR_0119 NC_010612.1 144293 145480 D function unknown but some domain identity with nitroreductase-related proteins; hypothetical protein 144293..145480 Mycobacterium marinum M 6224336 YP_001848445.1 CDS MMAR_0120 NC_010612.1 145613 147001 D function unknown but contains C-term predicted ATPase domain (AAA+ superfamily); hypothetical protein 145613..147001 Mycobacterium marinum M 6224337 YP_001848446.1 CDS MMAR_0121 NC_010612.1 147163 149505 D decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [catalytic activity: formate + NAD(+) = CO(2) + NADH]; formate dehydrogenase H 147163..149505 Mycobacterium marinum M 6224338 YP_001848447.1 CDS cyp279A2 NC_010612.1 149522 150760 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 279A2 Cyp279A2 complement(149522..150760) Mycobacterium marinum M 6224339 YP_001848448.1 CDS MMAR_0123 NC_010612.1 150923 154276 D involved in transcriptional mechanism; LuxR family transcriptional regulator 150923..154276 Mycobacterium marinum M 6224340 YP_001848449.1 CDS MMAR_0124 NC_010612.1 154332 155273 R possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone oxidoreductase complement(154332..155273) Mycobacterium marinum M 6224341 YP_001848450.1 CDS MMAR_0125 NC_010612.1 155386 155832 D MarR family transcriptional regulator 155386..155832 Mycobacterium marinum M 6224342 YP_001848451.1 CDS MMAR_0126 NC_010612.1 155864 156622 R hypothetical protein complement(155864..156622) Mycobacterium marinum M 6224343 YP_001848452.1 CDS adhD_1 NC_010612.1 156692 157801 R thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD- dependent, AdhD complement(156692..157801) Mycobacterium marinum M 6224344 YP_001848453.1 CDS MMAR_0128 NC_010612.1 157936 158958 R function unknown; may be involved in electron transfer; oxidoreductase complement(157936..158958) Mycobacterium marinum M 6224345 YP_001848454.1 CDS MMAR_0129 NC_010612.1 158967 159284 R function unknown, but the MmoB/DmpM family consists of monooxygenase components such as MmoB methane monooxygenase regulatory protein B. When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilises intermediates required for the activation of dioxygen; monooxygenase effector, MmoB/DmpM family protein complement(158967..159284) Mycobacterium marinum M 6224346 YP_001848455.1 CDS MMAR_0130 NC_010612.1 159281 160372 R function unknown, but enzymes in this family are involved in hydroxylation of hydrocarbons; monooxygenase hydroxylase, subunit B complement(159281..160372) Mycobacterium marinum M 6224347 YP_001848456.1 CDS MMAR_0131 NC_010612.1 160372 161910 R Enzymes in this family are involved in hydroxylation of hydrocarbons; monooxygenase hydroxylase, subunit A complement(160372..161910) Mycobacterium marinum M 6224348 YP_001848457.1 CDS MMAR_0132 NC_010612.1 162067 162729 D response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain; two-component transcriptional regulatory protein 162067..162729 Mycobacterium marinum M 6224349 YP_001848458.1 CDS MMAR_0133 NC_010612.1 162701 163795 R sensor part of the two-component regulatory system; two-component sensor histidine kinase complement(162701..163795) Mycobacterium marinum M 6224350 YP_001848459.1 CDS MMAR_0134 NC_010612.1 164203 164562 D hypothetical protein 164203..164562 Mycobacterium marinum M 6224351 YP_001848460.1 CDS MMAR_0135 NC_010612.1 164572 165291 D hypothetical protein 164572..165291 Mycobacterium marinum M 6224352 YP_001848461.1 CDS MMAR_0136 NC_010612.1 165450 166634 D intergral membrane protein 165450..166634 Mycobacterium marinum M 6224353 YP_001848462.1 CDS MMAR_0137 NC_010612.1 166686 166952 D hypothetical protein 166686..166952 Mycobacterium marinum M 6224354 YP_001848463.1 CDS MMAR_0138 NC_010612.1 166992 168185 R hypothetical protein complement(166992..168185) Mycobacterium marinum M 6224355 YP_001848464.1 CDS fadE6_1 NC_010612.1 168341 170566 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE6 complement(168341..170566) Mycobacterium marinum M 6224356 YP_001848465.1 CDS MMAR_0140 NC_010612.1 170574 171440 R hypothetical protein complement(170574..171440) Mycobacterium marinum M 6224357 YP_001848466.1 CDS MMAR_0141 NC_010612.1 171755 172330 D involved in transcriptional mechanism; TetR family transcriptional regulator 171755..172330 Mycobacterium marinum M 6224358 YP_001848467.1 CDS ltp1_1 NC_010612.1 172339 173550 R possibly catalyzes the transfer of a great variety of lipids between membranes; lipid-transfer protein Ltp1 complement(172339..173550) Mycobacterium marinum M 6224359 YP_001848468.1 CDS MMAR_0143 NC_010612.1 173581 173979 R hypothetical protein complement(173581..173979) Mycobacterium marinum M 6224360 YP_001848469.1 CDS MMAR_0144 NC_010612.1 174075 174491 R hypothetical protein complement(174075..174491) Mycobacterium marinum M 6224361 YP_001848470.1 CDS MMAR_0145 NC_010612.1 174522 175013 R transcriptional regulator complement(174522..175013) Mycobacterium marinum M 6224362 YP_001848471.1 CDS MMAR_0146 NC_010612.1 175147 176310 D ATPase 175147..176310 Mycobacterium marinum M 6224363 YP_001848472.1 CDS MMAR_0147 NC_010612.1 176332 177075 R function unknown; hypothetical protein complement(176332..177075) Mycobacterium marinum M 6224364 YP_001848473.1 CDS MMAR_0148 NC_010612.1 177130 178338 R function unknown, glycosyltransferases, related to UDP-glucuronosyltransferase; glycosyltransferase complement(177130..178338) Mycobacterium marinum M 6224365 YP_001848474.1 CDS fadE25_2 NC_010612.1 178407 179618 R function unknown, but involved in lipid degradation [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]; acyl-CoA dehydrogenase FadE25_2 complement(178407..179618) Mycobacterium marinum M 6224366 YP_001848475.1 CDS MMAR_0150 NC_010612.1 179647 180291 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(179647..180291) Mycobacterium marinum M 6224367 YP_001848476.1 CDS eis1 NC_010612.1 180345 181562 R supposed involved in intracellular survival. possibly associated with the cell surface and secreted; hypothetical protein complement(180345..181562) Mycobacterium marinum M 6224368 YP_001848477.1 CDS MMAR_0152 NC_010612.1 181702 182268 R hypothetical protein complement(181702..182268) Mycobacterium marinum M 6224369 YP_001848478.1 CDS MMAR_0153 NC_010612.1 182396 182827 D hypothetical protein 182396..182827 Mycobacterium marinum M 6224370 YP_001848479.1 CDS MMAR_0154 NC_010612.1 182886 183926 D function unknown, probably involved in cellular metabolism; coenzyme F420-dependent oxidoreductase 182886..183926 Mycobacterium marinum M 6224371 YP_001848480.1 CDS fadE36_1 NC_010612.1 183948 185015 R function unknown, but possibly involvement in lipid degradation; acyl-CoA dehydrogenase FadE36 complement(183948..185015) Mycobacterium marinum M 6224372 YP_001848481.1 CDS fadE2_1 NC_010612.1 185034 186257 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE2 complement(185034..186257) Mycobacterium marinum M 6224373 YP_001848482.1 CDS cyaA NC_010612.1 186380 187504 R possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; adenylate cyclase CyaA complement(186380..187504) Mycobacterium marinum M 6224374 YP_001848483.1 CDS icd2 NC_010612.1 187618 189855 R involved in the krebs cycle [catalytic activity: isocitrate + NADP+ = 2-oxoglutarate + CO(2) + NADPH]; isocitrate dehydrogenase [NADP] Icd2 complement(187618..189855) Mycobacterium marinum M 6224375 YP_001848484.1 CDS MMAR_0159 NC_010612.1 190532 191368 R hypothetical protein complement(190532..191368) Mycobacterium marinum M 6224376 YP_001848485.1 CDS MMAR_0160 NC_010612.1 191358 192149 R function unknown. possibly secreted; hypothetical protein complement(191358..192149) Mycobacterium marinum M 6224377 YP_001848486.1 CDS MMAR_0161 NC_010612.1 192161 192886 R hypothetical protein complement(192161..192886) Mycobacterium marinum M 6224378 YP_001848487.1 CDS MMAR_0162 NC_010612.1 193261 194349 D hypothetical protein 193261..194349 Mycobacterium marinum M 6224379 YP_001848488.1 CDS MMAR_0163 NC_010612.1 194342 195523 D hypothetical protein 194342..195523 Mycobacterium marinum M 6224380 YP_001848489.1 CDS MMAR_0164 NC_010612.1 195523 196503 D function unknown, probably involved in cellular metabolism; nucleoside-diphosphate-sugar epimerase 195523..196503 Mycobacterium marinum M 6224381 YP_001848490.1 CDS MMAR_0165 NC_010612.1 196500 197597 D function unknown; hypothetical protein 196500..197597 Mycobacterium marinum M 6224382 YP_001848491.1 CDS gabT_2 NC_010612.1 197597 198946 D 4-aminobutyrate aminotransferase 197597..198946 Mycobacterium marinum M 6224383 YP_001848492.1 CDS MMAR_0167 NC_010612.1 198943 200451 D catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)]; glutamate decarboxylase 198943..200451 Mycobacterium marinum M 6224384 YP_001848493.1 CDS MMAR_0168 NC_010612.1 200448 201191 D hypothetical protein 200448..201191 Mycobacterium marinum M 6224385 YP_001848494.1 CDS MMAR_0169 NC_010612.1 201188 201694 D hypothetical protein 201188..201694 Mycobacterium marinum M 6224386 YP_001848495.1 CDS MMAR_0170 NC_010612.1 201706 202434 D hypothetical protein 201706..202434 Mycobacterium marinum M 6224387 YP_001848496.1 CDS MMAR_0171 NC_010612.1 202409 203383 D probably involved in active transport of substrate across the membrane (export). responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 202409..203383 Mycobacterium marinum M 6224388 YP_001848497.1 CDS MMAR_0172 NC_010612.1 203380 204156 D hypothetical protein 203380..204156 Mycobacterium marinum M 6224389 YP_001848498.1 CDS MMAR_0173 NC_010612.1 204172 204453 D thought to be involved in de novo fatty acid biosynthesis; this protein is the carrier of the growing fatty acid chain in fatty acid biosynthesis; acyl carrier protein 204172..204453 Mycobacterium marinum M 6224390 YP_001848499.1 CDS pks16_1 NC_010612.1 204462 206102 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 204462..206102 Mycobacterium marinum M 6224391 YP_001848500.1 CDS yrbE6A NC_010612.1 206112 206957 D integral membrane protein YrbE6A 206112..206957 Mycobacterium marinum M 6224392 YP_001848501.1 CDS yrbE6B NC_010612.1 206959 207825 D integral membrane protein YrbE6B 206959..207825 Mycobacterium marinum M 6224393 YP_001848502.1 CDS mce6A NC_010612.1 207828 209318 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce6A 207828..209318 Mycobacterium marinum M 6224394 YP_001848503.1 CDS mce6B NC_010612.1 209337 210410 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce6B 209337..210410 Mycobacterium marinum M 6224395 YP_001848504.1 CDS mce6C NC_010612.1 210403 211449 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce6C 210403..211449 Mycobacterium marinum M 6224396 YP_001848505.1 CDS mce6D NC_010612.1 211446 212558 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce6D 211446..212558 Mycobacterium marinum M 6224397 YP_001848506.1 CDS mce6E NC_010612.1 212555 213682 D function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein Mce6E 212555..213682 Mycobacterium marinum M 6224398 YP_001848507.1 CDS mce6F NC_010612.1 213679 214917 D function unknown, but thought involved in host cell invasion; MCE-family protein Mce6F 213679..214917 Mycobacterium marinum M 6224399 YP_001848508.1 CDS MMAR_0183 NC_010612.1 215603 218155 D PE-PGRS family protein 215603..218155 Mycobacterium marinum M 6224400 YP_001848509.1 CDS MMAR_0184 NC_010612.1 218996 220441 D hypothetical protein 218996..220441 Mycobacterium marinum M 6224401 YP_001848510.1 CDS MMAR_0185 NC_010612.1 220525 220821 D PE family protein 220525..220821 Mycobacterium marinum M 6224402 YP_001848511.1 CDS MMAR_0186 NC_010612.1 220878 221984 D PPE family protein 220878..221984 Mycobacterium marinum M 6224403 YP_001848512.1 CDS esxB_1 NC_010612.1 222089 222391 D a culture filtrate antigen that forms part of a novel secretion apparatus; 10 kDa culture filtrate antigen EsxB 222089..222391 Mycobacterium marinum M 6224404 YP_001848513.1 CDS esxA_1 NC_010612.1 222428 222715 D 6kDA, culture filtrate antigen forms part of a novel secretion apparatus; 6 kDa culture filtrate antigen EsxA 222428..222715 Mycobacterium marinum M 6224405 YP_001848514.1 CDS esxA_3 NC_010612.1 222948 223235 D function unknown but identity with other Esx proteins, including EsxA; EsxA-like protein, EsxA_3 222948..223235 Mycobacterium marinum M 6224406 YP_001848515.1 CDS MMAR_0190 NC_010612.1 223485 223664 D hypothetical protein 223485..223664 Mycobacterium marinum M 6224407 YP_001848516.1 CDS MMAR_0191 NC_010612.1 223778 224923 D PPE family protein 223778..224923 Mycobacterium marinum M 6224408 YP_001848517.1 CDS MMAR_0193 NC_010612.1 225330 225551 D hypothetical protein 225330..225551 Mycobacterium marinum M 6224409 YP_001848518.1 CDS MMAR_0194 NC_010612.1 225548 225676 D hypothetical protein 225548..225676 Mycobacterium marinum M 6224410 YP_001848519.1 CDS esxB_2 NC_010612.1 225736 226038 D EsxB-like protein, EsxB_2 225736..226038 Mycobacterium marinum M 6224411 YP_001848520.1 CDS esxA_2 NC_010612.1 226072 226359 D EsxA-like protein, EsxA_2 226072..226359 Mycobacterium marinum M 6224412 YP_001848521.1 CDS MMAR_0197 NC_010612.1 226403 226750 D hypothetical protein 226403..226750 Mycobacterium marinum M 6224413 YP_001848522.1 CDS MMAR_0198 NC_010612.1 226758 227129 D hypothetical protein 226758..227129 Mycobacterium marinum M 6224414 YP_001848523.1 CDS MMAR_0199 NC_010612.1 227133 229202 D hypothetical protein 227133..229202 Mycobacterium marinum M 6224415 YP_001848524.1 CDS MMAR_0200 NC_010612.1 229316 229807 D hypothetical protein 229316..229807 Mycobacterium marinum M 6224416 YP_001848525.1 CDS MMAR_0201 NC_010612.1 229926 230201 R hypothetical protein complement(229926..230201) Mycobacterium marinum M 6224417 YP_001848526.1 CDS MMAR_0202 NC_010612.1 230276 231814 R hypothetical protein complement(230276..231814) Mycobacterium marinum M 6224418 YP_001848527.1 CDS MMAR_0203 NC_010612.1 232431 233972 D hypothetical protein 232431..233972 Mycobacterium marinum M 6224419 YP_001848528.1 CDS MMAR_0204 NC_010612.1 234056 234607 D hypothetical protein 234056..234607 Mycobacterium marinum M 6224420 YP_001848529.1 CDS MMAR_0205 NC_010612.1 234666 236270 R function unknown, probably involved in cellular metabolism; hypothetical protein complement(234666..236270) Mycobacterium marinum M 6224421 YP_001848530.1 CDS sdaA NC_010612.1 236388 237773 R involved in gluconeogenesis from serine [catalytic activity: L-serine + H2O = pyruvate + NH3 + H2O]; L-serine dehydratase SdaA complement(236388..237773) Mycobacterium marinum M 6224422 YP_001848531.1 CDS glyA NC_010612.1 237770 239047 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(237770..239047) Mycobacterium marinum M 6224423 YP_001848532.1 CDS gcvH_1 NC_010612.1 239044 239448 R the glycine cleavage system catalyses the degradation of glycine. the H protein shuttles the methylamine group of glycine from the P protein to the T protein; glycine cleavage system H protein GcvH complement(239044..239448) Mycobacterium marinum M 6224424 YP_001848533.1 CDS gcvT NC_010612.1 239495 240622 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(239495..240622) Mycobacterium marinum M 6224425 YP_001848534.1 CDS gcvB_1 NC_010612.1 240640 243525 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(240640..243525) Mycobacterium marinum M 6224426 YP_001848535.1 CDS MMAR_5544 NC_010612.1 243865 243963 D hypothetical protein 243865..243963 Mycobacterium marinum M 6224427 YP_001848536.1 CDS MMAR_0212 NC_010612.1 244095 245465 R function unknown; involved in cellular metabolism; oxidoreductase complement(244095..245465) Mycobacterium marinum M 6224428 YP_001848537.1 CDS MMAR_0213 NC_010612.1 245475 247235 R hydrolizes specific D-amino acid; D-amino acid aminohydrolase complement(245475..247235) Mycobacterium marinum M 6224429 YP_001848538.1 CDS MMAR_0214 NC_010612.1 247401 247778 R function unknown. domain identity suggests anti- anti-sigma regulatory factor; hypothetical protein complement(247401..247778) Mycobacterium marinum M 6224430 YP_001848539.1 CDS MMAR_0215 NC_010612.1 248068 249117 D involved in active transport of glutamine across the membrane (import). responsible for the translocation of the substrate across the membrane; glutamine-transport transmembrane protein ABC transporter 248068..249117 Mycobacterium marinum M 6224431 YP_001848540.1 CDS MMAR_0216 NC_010612.1 249121 250113 D involved in active transport of glutamine across the membrane (import). responsible for the translocation of the substrate across the membrane; glutamine-transport ABC transporter ATP-binding protein 249121..250113 Mycobacterium marinum M 6224432 YP_001848541.1 CDS MMAR_0217 NC_010612.1 250135 251085 R lipoprotein complement(250135..251085) Mycobacterium marinum M 6224433 YP_001848542.1 CDS MMAR_0218 NC_010612.1 251170 252468 R hypothetical protein complement(251170..252468) Mycobacterium marinum M 6224434 YP_001848543.1 CDS MMAR_0219 NC_010612.1 252597 252974 R hypothetical protein complement(252597..252974) Mycobacterium marinum M 6224435 YP_001848544.1 CDS MMAR_0220 NC_010612.1 253047 254222 R hypothetical protein complement(253047..254222) Mycobacterium marinum M 6224436 YP_001848545.1 CDS MMAR_0221 NC_010612.1 254219 255316 R hypothetical protein complement(254219..255316) Mycobacterium marinum M 6224437 YP_001848546.1 CDS MMAR_0222 NC_010612.1 255379 255972 D involved in transcriptional mechanism; TetR family transcriptional regulator 255379..255972 Mycobacterium marinum M 6224438 YP_001848547.1 CDS MMAR_0223 NC_010612.1 256036 256866 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(256036..256866) Mycobacterium marinum M 6224439 YP_001848548.1 CDS MMAR_0224 NC_010612.1 256927 257532 D possibly involved in transcriptional mechanism; transcriptional regulatory protein 256927..257532 Mycobacterium marinum M 6224440 YP_001848549.1 CDS MMAR_0225 NC_010612.1 257653 258273 D hypothetical protein 257653..258273 Mycobacterium marinum M 6224441 YP_001848550.1 CDS MMAR_0226 NC_010612.1 258629 259237 D hypothetical protein 258629..259237 Mycobacterium marinum M 6224442 YP_001848551.1 CDS lpqP_1 NC_010612.1 259288 260268 R lipoprotein LpqP complement(259288..260268) Mycobacterium marinum M 6224443 YP_001848552.1 CDS MMAR_0228 NC_010612.1 260305 260754 D function unknown. contains HTH motif. may be involved in transcription regulation; hypothetical protein 260305..260754 Mycobacterium marinum M 6224444 YP_001848553.1 CDS MMAR_0229 NC_010612.1 260799 261605 R hypothetical protein complement(260799..261605) Mycobacterium marinum M 6224445 YP_001848554.1 CDS MMAR_0230 NC_010612.1 261665 262849 D function unknown, involved in cellular metabolism; dioxygenase 261665..262849 Mycobacterium marinum M 6224446 YP_001848555.1 CDS ctpA_1 NC_010612.1 262878 265247 R cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; ATPase P complement(262878..265247) Mycobacterium marinum M 6224447 YP_001848556.1 CDS MMAR_0232 NC_010612.1 265258 266148 R hypothetical protein complement(265258..266148) Mycobacterium marinum M 6224448 YP_001848557.1 CDS MMAR_0233 NC_010612.1 266145 266357 R contains copper chaperone domain; hypothetical protein complement(266145..266357) Mycobacterium marinum M 6224449 YP_001848558.1 CDS MMAR_0234 NC_010612.1 266541 267032 D hypothetical protein 266541..267032 Mycobacterium marinum M 6224450 YP_001848559.1 CDS MMAR_0235 NC_010612.1 267056 267619 R pyridoxamine 5'-phosphate oxidase complement(267056..267619) Mycobacterium marinum M 6224451 YP_001848560.1 CDS MMAR_0236 NC_010612.1 267658 268668 R function unknown. possibly involved in cellular metabolism; hypothetical protein complement(267658..268668) Mycobacterium marinum M 6224452 YP_001848561.1 CDS MMAR_0237 NC_010612.1 268665 269282 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(268665..269282) Mycobacterium marinum M 6224453 YP_001848562.1 CDS MMAR_0238 NC_010612.1 269478 270107 D involved in transcriptional mechanism; TetR family transcriptional regulator 269478..270107 Mycobacterium marinum M 6224454 YP_001848563.1 CDS MMAR_0239 NC_010612.1 270210 272009 D function unknown; probably involved in cellular metabolism; monooxygenase 270210..272009 Mycobacterium marinum M 6224455 YP_001848564.1 CDS MMAR_0240 NC_010612.1 272006 273682 D function unknown, involved in cellular metabolism; monoooxygenase 272006..273682 Mycobacterium marinum M 6224456 YP_001848565.1 CDS adhD NC_010612.1 273566 274723 R function unknown, generates an aldehyde (or perhaps a ketone) from an alcohol; zinc-type alcohol dehydrogenase AdhD complement(273566..274723) Mycobacterium marinum M 6224457 YP_001848566.1 CDS MMAR_0242 NC_010612.1 274874 276589 D PE-PGRS family protein 274874..276589 Mycobacterium marinum M 6224458 YP_001848567.1 CDS MMAR_0243 NC_010612.1 276635 277447 R function unknown, possibly involved in cellular metabolism; short chain dehydrogenase complement(276635..277447) Mycobacterium marinum M 6224459 YP_001848568.1 CDS MMAR_0244 NC_010612.1 277563 278162 D thought to cause methylation; methyltransferase/methylase 277563..278162 Mycobacterium marinum M 6224460 YP_001848569.1 CDS echA8_7 NC_010612.1 278220 279029 R oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_7 complement(278220..279029) Mycobacterium marinum M 6224461 YP_001848570.1 CDS MMAR_0246 NC_010612.1 279266 280096 D hypothetical protein 279266..280096 Mycobacterium marinum M 6224462 YP_001848571.1 CDS MMAR_0247 NC_010612.1 280121 280735 R hypothetical protein complement(280121..280735) Mycobacterium marinum M 6224463 YP_001848572.1 CDS MMAR_0248 NC_010612.1 280805 281665 D function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 280805..281665 Mycobacterium marinum M 6224464 YP_001848573.1 CDS MMAR_0249 NC_010612.1 281711 282340 D possibly involved in transcriptional mechanism; TetR family transcriptional regulator 281711..282340 Mycobacterium marinum M 6224465 YP_001848574.1 CDS MMAR_0250 NC_010612.1 282337 283161 D hypothetical protein 282337..283161 Mycobacterium marinum M 6224466 YP_001848575.1 CDS mtn NC_010612.1 283272 284027 D responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and s- adenosylhomocysteine (sah) [catalytic activity 1: methylthioadenosine + H2O = adenine + 5-methylthio-D- ribose] [catalytic activity 2: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine]; bifunctional Mta/Sah nucleosidase Mtn 283272..284027 Mycobacterium marinum M 6224467 YP_001848576.1 CDS MMAR_0253 NC_010612.1 284385 284870 D hypothetical protein 284385..284870 Mycobacterium marinum M 6224468 YP_001848577.1 CDS MMAR_0254 NC_010612.1 284972 285775 D function unknown, but possibly involvement in lipid metabolism; ketoacyl reductase 284972..285775 Mycobacterium marinum M 6224469 YP_001848578.1 CDS mmpL5_4 NC_010612.1 285857 288769 D thought to be involved in fatty acid transport; transmembrane transport protein MmpL 285857..288769 Mycobacterium marinum M 6224470 YP_001848579.1 CDS MMAR_0256 NC_010612.1 288793 293043 R involved in lipid metabolism; non-ribosomal peptide synthetase complement(288793..293043) Mycobacterium marinum M 6224471 YP_001848580.1 CDS MMAR_0257 NC_010612.1 293040 293291 R hypothetical protein complement(293040..293291) Mycobacterium marinum M 6224472 YP_001848581.1 CDS fadD10 NC_010612.1 293284 294879 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(293284..294879) Mycobacterium marinum M 6224473 YP_001848582.1 CDS MMAR_0259 NC_010612.1 294908 295462 R hypothetical protein complement(294908..295462) Mycobacterium marinum M 6224474 YP_001848583.1 CDS MMAR_0260 NC_010612.1 295459 296328 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(295459..296328) Mycobacterium marinum M 6224475 YP_001848584.1 CDS MMAR_0261 NC_010612.1 296522 297940 R PPE family protein complement(296522..297940) Mycobacterium marinum M 6224476 YP_001848585.1 CDS omt_1 NC_010612.1 298268 299077 D function unknown, but supposed involved in lipid metabolism; O-methyltransferase Omt 298268..299077 Mycobacterium marinum M 6224477 YP_001848586.1 CDS MMAR_0263 NC_010612.1 299159 299872 D hypothetical protein 299159..299872 Mycobacterium marinum M 6224478 YP_001848587.1 CDS ctpA NC_010612.1 299893 302184 R cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation transporter p-type ATPase a CtpA complement(299893..302184) Mycobacterium marinum M 6224479 YP_001848588.1 CDS sigC_1 NC_010612.1 302309 302863 D involved in promoter recognition, transcription initiation; ECF subfamily RNA polymerase sigma factor 302309..302863 Mycobacterium marinum M 6224480 YP_001848589.1 CDS MMAR_0266 NC_010612.1 302899 303642 R hypothetical protein complement(302899..303642) Mycobacterium marinum M 6224481 YP_001848590.1 CDS MMAR_0267 NC_010612.1 303807 305783 D integral membrane protein 303807..305783 Mycobacterium marinum M 6224482 YP_001848591.1 CDS MMAR_0268 NC_010612.1 305800 306018 R hypothetical protein complement(305800..306018) Mycobacterium marinum M 6224483 YP_001848592.1 CDS ctpB NC_010612.1 306011 308284 R cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly coopper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + orthophosphate + cation(out)]; cation-transporter p-type ATPase B CtpB complement(306011..308284) Mycobacterium marinum M 6224484 YP_001848593.1 CDS MMAR_0271 NC_010612.1 308529 309335 R function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase complement(308529..309335) Mycobacterium marinum M 6224485 YP_001848594.1 CDS cyp226B1 NC_010612.1 309447 310718 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 226B1 Cyp226B1 complement(309447..310718) Mycobacterium marinum M 6224486 YP_001848595.1 CDS MMAR_0273 NC_010612.1 311150 312412 R function unknown role in cellular metabolism; amidohydrolase complement(311150..312412) Mycobacterium marinum M 6224487 YP_001848596.1 CDS cyp271A1 NC_010612.1 312399 313694 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 271A1 Cyp271A1 complement(312399..313694) Mycobacterium marinum M 6224488 YP_001848597.1 CDS ispG NC_010612.1 313695 314858 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(313695..314858) Mycobacterium marinum M 6224489 YP_001848598.1 CDS dxs2 NC_010612.1 314855 316708 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(314855..316708) Mycobacterium marinum M 6224490 YP_001848599.1 CDS lytB2 NC_010612.1 316705 317706 R LytB is involved in the trunk line of the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis; LytB-related protein LytB2 complement(316705..317706) Mycobacterium marinum M 6224491 YP_001848600.1 CDS MMAR_0278 NC_010612.1 317703 318719 R hypothetical protein complement(317703..318719) Mycobacterium marinum M 6224492 YP_001848601.1 CDS MMAR_0279 NC_010612.1 318780 319523 R hypothetical protein complement(318780..319523) Mycobacterium marinum M 6224493 YP_001848602.1 CDS MMAR_0280 NC_010612.1 319581 320576 R involved in isoprenoid biosynthesis. enzymes in this class catalyze the ionization of farnesyl diphosphate, followed by the formation of a macrocyclic intermediate by bond formation between C1 with either C10 (aristolochene synthase) or C11 (pentalenene synthase), resulting in production of tricyclic hydrocarbon pentalenene or bicyclic hydrocarbon aristolochene; non-plant terpene cyclase (C1 class) complement(319581..320576) Mycobacterium marinum M 6224494 YP_001848603.1 CDS cyp183B1 NC_010612.1 320584 321972 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. some have been shown to bind tightly to a range of azole-based antifungal drugs (E.G. miconazole, clotrimazole); cytochrome P450 183B1 Cyp183B1 complement(320584..321972) Mycobacterium marinum M 6224495 YP_001848604.1 CDS idsB_3 NC_010612.1 321985 322974 R involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; polyprenyl synthetase IdsB_3 complement(321985..322974) Mycobacterium marinum M 6224496 YP_001848605.1 CDS cyp274A1 NC_010612.1 323882 325237 D cytochrome P450 are a group of heme-thiolate monooxygenases. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 274A1 Cyp274A1 323882..325237 Mycobacterium marinum M 6224497 YP_001848606.1 CDS plcB_3 NC_010612.1 325297 327039 D hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 325297..327039 Mycobacterium marinum M 6224498 YP_001848607.1 CDS MMAR_0285 NC_010612.1 327193 328710 D hypothetical protein 327193..328710 Mycobacterium marinum M 6224499 YP_001848608.1 CDS lipJ NC_010612.1 328780 330156 R function unknown, probably involved in cellular metabolism; lignin peroxidase LipJ complement(328780..330156) Mycobacterium marinum M 6224500 YP_001848609.1 CDS MMAR_0287 NC_010612.1 330159 330764 R involved in transcriptional mechanism; transcriptional regulatory protein complement(330159..330764) Mycobacterium marinum M 6224501 YP_001848610.1 CDS MMAR_0288 NC_010612.1 330953 331903 D hypothetical protein 330953..331903 Mycobacterium marinum M 6224502 YP_001848611.1 CDS rpsR2 NC_010612.1 331924 332187 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(331924..332187) Mycobacterium marinum M 6224503 YP_001848612.1 CDS rpsN NC_010612.1 332194 332499 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(332194..332499) Mycobacterium marinum M 6224504 YP_001848613.1 CDS rpmG NC_010612.1 332500 332664 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(332500..332664) Mycobacterium marinum M 6224505 YP_001848614.1 CDS rpmB2 NC_010612.1 332664 332900 R involved in ribosome activity; 50S ribosomal protein L28 complement(332664..332900) Mycobacterium marinum M 6224506 YP_001848615.1 CDS MMAR_0293 NC_010612.1 333030 334226 D hypothetical protein 333030..334226 Mycobacterium marinum M 6224507 YP_001848616.1 CDS rpmE2 NC_010612.1 334223 334495 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 334223..334495 Mycobacterium marinum M 6224508 YP_001848617.1 CDS MMAR_0295 NC_010612.1 334665 335564 D function unknown; supposed involved in cellular metabolism; short-chain type dehydrogenase/reductase 334665..335564 Mycobacterium marinum M 6224509 YP_001848618.1 CDS fadD12_2 NC_010612.1 335567 337153 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 335567..337153 Mycobacterium marinum M 6224510 YP_001848619.1 CDS ctpI NC_010612.1 337126 341988 R cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly magnesium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation-transporter ATPase I CtpI complement(337126..341988) Mycobacterium marinum M 6224511 YP_001848620.1 CDS MMAR_0298 NC_010612.1 342457 342729 R hypothetical protein complement(342457..342729) Mycobacterium marinum M 6224512 YP_001848621.1 CDS MMAR_0299 NC_010612.1 343064 344737 D PE-PGRS family protein 343064..344737 Mycobacterium marinum M 6224513 YP_001848622.1 CDS MMAR_0300 NC_010612.1 344862 345731 D serine protease 344862..345731 Mycobacterium marinum M 6224514 YP_001848623.1 CDS MMAR_0301 NC_010612.1 345766 346227 D hypothetical protein 345766..346227 Mycobacterium marinum M 6224515 YP_001848624.1 CDS MMAR_0302 NC_010612.1 346209 346997 R function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase complement(346209..346997) Mycobacterium marinum M 6224516 YP_001848625.1 CDS MMAR_0303 NC_010612.1 346999 348609 R acyl-CoA synthetase complement(346999..348609) Mycobacterium marinum M 6224517 YP_001848626.1 CDS MMAR_0304 NC_010612.1 348619 349398 R involved in transcriptional mechanism; GntR family transcriptional regulator complement(348619..349398) Mycobacterium marinum M 6224518 YP_001848627.1 CDS MMAR_0305 NC_010612.1 349411 351033 R hypothetical protein complement(349411..351033) Mycobacterium marinum M 6224519 YP_001848628.1 CDS MMAR_0306 NC_010612.1 351170 352045 D function unknown; possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 351170..352045 Mycobacterium marinum M 6224520 YP_001848629.1 CDS MMAR_0307 NC_010612.1 352047 353441 D function unknown; involved in cellular metabolism; dioxygenase 352047..353441 Mycobacterium marinum M 6224521 YP_001848630.1 CDS MMAR_0308 NC_010612.1 353456 354637 D function unknown, probably involved in cellular metabolism; monooxygenase 353456..354637 Mycobacterium marinum M 6224522 YP_001848631.1 CDS MMAR_0309 NC_010612.1 354634 356496 D function unknown, probably involved in cellular metabolism; monoxygenase 354634..356496 Mycobacterium marinum M 6224523 YP_001848632.1 CDS MMAR_0310 NC_010612.1 356496 357431 D function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 356496..357431 Mycobacterium marinum M 6224524 YP_001848633.1 CDS MMAR_0311 NC_010612.1 357424 358644 D function unknown. possibly involved in energy production and conversion; hypothetical protein 357424..358644 Mycobacterium marinum M 6224525 YP_001848634.1 CDS MMAR_0312 NC_010612.1 358882 360894 D function unknown, probably involved in cellular metabolism; transmembrane acyltransferase 358882..360894 Mycobacterium marinum M 6224560 YP_001848635.1 CDS MMAR_0313 NC_010612.1 360898 361563 R thought to be involved in transfer of methyl group; O-methyltransferase complement(360898..361563) Mycobacterium marinum M 6224561 YP_001848636.1 CDS MMAR_0314 NC_010612.1 362138 362353 D hypothetical protein 362138..362353 Mycobacterium marinum M 6224562 YP_001848637.1 CDS MMAR_0315 NC_010612.1 362455 364209 D H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane; divalent cation-transport integral membrane protein 362455..364209 Mycobacterium marinum M 6224563 YP_001848638.1 CDS MMAR_0316 NC_010612.1 364261 365016 R hypothetical protein complement(364261..365016) Mycobacterium marinum M 6224564 YP_001848639.1 CDS oxyS NC_010612.1 365147 366364 D could effect functions of OxyR during evolution; oxidative stress response regulatory protein OxyS 365147..366364 Mycobacterium marinum M 6224565 YP_001848640.1 CDS oxcA NC_010612.1 366348 368111 R catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase complement(366348..368111) Mycobacterium marinum M 6224566 YP_001848641.1 CDS fadD7 NC_010612.1 368378 370012 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 368378..370012 Mycobacterium marinum M 6224567 YP_001848642.1 CDS MMAR_0320 NC_010612.1 370009 370485 R hypothetical protein complement(370009..370485) Mycobacterium marinum M 6224568 YP_001848643.1 CDS fusA2 NC_010612.1 370501 372657 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(370501..372657) Mycobacterium marinum M 6224569 YP_001848644.1 CDS MMAR_0322 NC_010612.1 372828 373229 R hypothetical protein complement(372828..373229) Mycobacterium marinum M 6224570 YP_001848645.1 CDS MMAR_0323 NC_010612.1 373300 373800 D maybe involved in oxidization of aromatic hydrocarbons; dioxygenase subunit beta 373300..373800 Mycobacterium marinum M 6224571 YP_001848646.1 CDS pepA NC_010612.1 373913 374986 D function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues); serine protease PepA 373913..374986 Mycobacterium marinum M 6224572 YP_001848647.1 CDS treS NC_010612.1 375105 376892 D involved in trehalose biosynthesis (protective effect). converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); trehalose synthase TreS 375105..376892 Mycobacterium marinum M 6224573 YP_001848648.1 CDS MMAR_0326 NC_010612.1 376966 378333 D hypothetical protein 376966..378333 Mycobacterium marinum M 6224574 YP_001848649.1 CDS MMAR_0327 NC_010612.1 378448 379128 D hypothetical protein 378448..379128 Mycobacterium marinum M 6224575 YP_001848650.1 CDS fbpC NC_010612.1 379208 380248 R proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted antigen 85-C FbpC complement(379208..380248) Mycobacterium marinum M 6224576 YP_001848651.1 CDS MMAR_0329 NC_010612.1 380601 381098 R phosphoesterase complement(380601..381098) Mycobacterium marinum M 6224577 YP_001848652.1 CDS MMAR_0330 NC_010612.1 381135 381590 D acyl dehydratase 381135..381590 Mycobacterium marinum M 6224578 YP_001848653.1 CDS fadE1 NC_010612.1 381671 382966 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE1 complement(381671..382966) Mycobacterium marinum M 6224579 YP_001848654.1 CDS MMAR_0332 NC_010612.1 383128 383733 D function unknown, probably involved in cellular metabolism; acetyltransferase 383128..383733 Mycobacterium marinum M 6224580 YP_001848655.1 CDS MMAR_0333 NC_010612.1 383770 385800 R hypothetical protein complement(383770..385800) Mycobacterium marinum M 6224581 YP_001848656.1 CDS MMAR_0334 NC_010612.1 385931 386599 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(385931..386599) Mycobacterium marinum M 6224582 YP_001848657.1 CDS MMAR_0335 NC_010612.1 386670 387767 D function unknown, contains flavodoxin reductases (ferredoxin-NADPH reductases) family 1 domain. [energy production and conversion]; flavodoxin oxidoreductase 386670..387767 Mycobacterium marinum M 6224583 YP_001848658.1 CDS desA3_2 NC_010612.1 387803 388936 D thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3_2 387803..388936 Mycobacterium marinum M 6224584 YP_001848659.1 CDS MMAR_0337 NC_010612.1 389206 389730 D hypothetical protein 389206..389730 Mycobacterium marinum M 6224585 YP_001848660.1 CDS MMAR_0338 NC_010612.1 389730 390788 D function unknown, probably involved in cellular metabolism; coenzyme F420-dependent oxidoreductase 389730..390788 Mycobacterium marinum M 6224586 YP_001848661.1 CDS MMAR_0339 NC_010612.1 390790 391902 R hypothetical protein complement(390790..391902) Mycobacterium marinum M 6224587 YP_001848662.1 CDS MMAR_0340 NC_010612.1 391899 392498 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(391899..392498) Mycobacterium marinum M 6224588 YP_001848663.1 CDS MMAR_0341 NC_010612.1 392605 393768 D hypothetical protein 392605..393768 Mycobacterium marinum M 6224589 YP_001848664.1 CDS ephF NC_010612.1 393807 394697 D thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphF 393807..394697 Mycobacterium marinum M 6224590 YP_001848665.1 CDS MMAR_0343 NC_010612.1 394761 395804 R oxido-reduction; zinc-dependent alcohol dehydrogenase complement(394761..395804) Mycobacterium marinum M 6224591 YP_001848666.1 CDS MMAR_0344 NC_010612.1 395811 396023 R hypothetical protein complement(395811..396023) Mycobacterium marinum M 6224592 YP_001848667.1 CDS MMAR_0345 NC_010612.1 396069 396674 R could be involved in transcriptional mechanism; transcriptional regulatory protein complement(396069..396674) Mycobacterium marinum M 6224593 YP_001848668.1 CDS cyp138A3 NC_010612.1 396804 398129 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 138A3 Cyp138A3 396804..398129 Mycobacterium marinum M 6224594 YP_001848669.1 CDS msrA NC_010612.1 398166 398681 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(398166..398681) Mycobacterium marinum M 6224595 YP_001848670.1 CDS MMAR_0348 NC_010612.1 398841 399347 D hypothetical protein 398841..399347 Mycobacterium marinum M 6224596 YP_001848671.1 CDS MMAR_0349 NC_010612.1 399344 400366 D function unknown, probably involved in cellular metabolism; oxidoreductase 399344..400366 Mycobacterium marinum M 6224597 YP_001848672.1 CDS MMAR_0350 NC_010612.1 400476 400856 D hypothetical protein 400476..400856 Mycobacterium marinum M 6224598 YP_001848673.1 CDS MMAR_0351 NC_010612.1 400843 401244 R hypothetical protein complement(400843..401244) Mycobacterium marinum M 6224599 YP_001848674.1 CDS MMAR_0352 NC_010612.1 401317 402228 D DNA glycosylase 401317..402228 Mycobacterium marinum M 6224600 YP_001848675.1 CDS MMAR_0353 NC_010612.1 402310 403716 R function unknown; possibly ion channel involved in transport of chloride across the membrane; hypothetical protein complement(402310..403716) Mycobacterium marinum M 6224601 YP_001848676.1 CDS MMAR_0354 NC_010612.1 403853 404839 D hypothetical protein 403853..404839 Mycobacterium marinum M 6224602 YP_001848677.1 CDS MMAR_0355 NC_010612.1 404839 405474 D involved in transcriptional mechanism; TetR family transcriptional regulator 404839..405474 Mycobacterium marinum M 6224603 YP_001848678.1 CDS MMAR_0356 NC_010612.1 405619 406551 D hypothetical protein 405619..406551 Mycobacterium marinum M 6224604 YP_001848679.1 CDS MMAR_0357 NC_010612.1 406565 407506 D O-methyltransferase 406565..407506 Mycobacterium marinum M 6224605 YP_001848680.1 CDS MMAR_0358 NC_010612.1 407506 408441 D O-methyltransferase 407506..408441 Mycobacterium marinum M 6224606 YP_001848681.1 CDS MMAR_0359 NC_010612.1 408591 410075 D function unknown, probably involved in cellular metabolism [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase (NAD+) dependent 408591..410075 Mycobacterium marinum M 6224607 YP_001848682.1 CDS MMAR_0360 NC_010612.1 410148 411008 D function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 410148..411008 Mycobacterium marinum M 6224608 YP_001848683.1 CDS MMAR_0361 NC_010612.1 411013 411981 D possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone oxidoreductase 411013..411981 Mycobacterium marinum M 6224609 YP_001848684.1 CDS MMAR_0362 NC_010612.1 412063 412443 R hypothetical protein complement(412063..412443) Mycobacterium marinum M 6224610 YP_001848685.1 CDS MMAR_0363 NC_010612.1 412445 413020 R hypothetical protein complement(412445..413020) Mycobacterium marinum M 6224611 YP_001848686.1 CDS MMAR_0364 NC_010612.1 413350 413568 D hypothetical protein 413350..413568 Mycobacterium marinum M 6224612 YP_001848687.1 CDS pknK_2 NC_010612.1 413629 416613 D involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase transcriptional regulatory protein PknK_2 413629..416613 Mycobacterium marinum M 6224613 YP_001848688.1 CDS pknK_3 NC_010612.1 416727 419777 D involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase transcriptional regulatory protein PknK_3 416727..419777 Mycobacterium marinum M 6224614 YP_001848689.1 CDS MMAR_0367 NC_010612.1 419959 420684 R function unknown; probably involved in lipid metabolism; thioesterase complement(419959..420684) Mycobacterium marinum M 6224615 YP_001848690.1 CDS MMAR_0368 NC_010612.1 420690 430259 R function unknown but contains 3 modules for the potential synthesis of a tripeptide; peptide synthetase Nrp (peptide synthase) complement(420690..430259) Mycobacterium marinum M 6224616 YP_001848691.1 CDS MMAR_0369 NC_010612.1 430989 432758 R PE family protein complement(430989..432758) Mycobacterium marinum M 6224617 YP_001848692.1 CDS MMAR_0370 NC_010612.1 433165 434817 R PE family protein complement(433165..434817) Mycobacterium marinum M 6224618 YP_001848693.1 CDS MMAR_0371 NC_010612.1 434987 436735 R PE family protein complement(434987..436735) Mycobacterium marinum M 6224619 YP_001848694.1 CDS MMAR_0372 NC_010612.1 436835 438487 R PE family protein complement(436835..438487) Mycobacterium marinum M 6224620 YP_001848695.1 CDS ptpB NC_010612.1 438612 439442 R involved in signal transduction (via dephosphorylation). can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0. could be involved in virulence by interfering with phosphotyrosine-mediated signals in macrophages [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate]; phosphotyrosine protein phosphatase PtpB complement(438612..439442) Mycobacterium marinum M 6224621 YP_001848696.1 CDS fadE2 NC_010612.1 439435 440685 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE2 complement(439435..440685) Mycobacterium marinum M 6224622 YP_001848697.1 CDS MMAR_0375 NC_010612.1 440810 441688 D hypothetical protein 440810..441688 Mycobacterium marinum M 6224623 YP_001848698.1 CDS MMAR_0376 NC_010612.1 441754 442224 D hypothetical protein 441754..442224 Mycobacterium marinum M 6224624 YP_001848699.1 CDS pntAa NC_010612.1 442468 443556 D the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenase PntA 442468..443556 Mycobacterium marinum M 6224625 YP_001848700.1 CDS pntAb NC_010612.1 443572 443910 D the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenase (subunit alpha) PntAb 443572..443910 Mycobacterium marinum M 6224626 YP_001848701.1 CDS pntB NC_010612.1 443907 445331 D the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenasePntB 443907..445331 Mycobacterium marinum M 6224627 YP_001848702.1 CDS MMAR_0380 NC_010612.1 445374 445499 R hypothetical protein complement(445374..445499) Mycobacterium marinum M 6224628 YP_001848703.1 CDS MMAR_0381 NC_010612.1 445667 446290 D involved in transcriptional mechanism; TetR family transcriptional regulator 445667..446290 Mycobacterium marinum M 6224629 YP_001848704.1 CDS MMAR_0382 NC_010612.1 446304 447785 R PE-PGRS family protein complement(446304..447785) Mycobacterium marinum M 6224630 YP_001848705.1 CDS MMAR_0383 NC_010612.1 447995 449485 R PE family protein complement(447995..449485) Mycobacterium marinum M 6224631 YP_001848706.1 CDS MMAR_0384 NC_010612.1 449637 451154 R PE family protein complement(449637..451154) Mycobacterium marinum M 6224632 YP_001848707.1 CDS MMAR_0385 NC_010612.1 451282 452190 R hypothetical protein complement(451282..452190) Mycobacterium marinum M 6224633 YP_001848708.1 CDS MMAR_0386 NC_010612.1 452296 453378 D hypothetical protein 452296..453378 Mycobacterium marinum M 6224634 YP_001848709.1 CDS fabG3 NC_010612.1 453398 454138 D thought to be involved in lipid biosynthesis [catalytic activity: androstan-3-alpha,17- beta-diol + NAD+ = 17-beta-hydroxyandrostan-3-one + NADH]; 20-beta-hydroxysteroid dehydrogenase FabG3 453398..454138 Mycobacterium marinum M 6224635 YP_001848710.1 CDS MMAR_0388 NC_010612.1 454159 455499 D function unknown, probably involved in cellular metabolism; oxidoreductase 454159..455499 Mycobacterium marinum M 6224636 YP_001848711.1 CDS MMAR_0389 NC_010612.1 455506 456051 R function unknown. contains TetR_N, bacterial regulatory proteins, TetR family domain. possibly involved in transcriptional mechanism; putative regulatory protein complement(455506..456051) Mycobacterium marinum M 6224637 YP_001848712.1 CDS MMAR_0390 NC_010612.1 456110 456925 R hypothetical protein complement(456110..456925) Mycobacterium marinum M 6224638 YP_001848713.1 CDS MMAR_0391 NC_010612.1 456965 457822 R hypothetical protein complement(456965..457822) Mycobacterium marinum M 6224639 YP_001848714.1 CDS MMAR_0392 NC_010612.1 457915 458805 D hypothetical protein 457915..458805 Mycobacterium marinum M 6224640 YP_001848715.1 CDS MMAR_0393 NC_010612.1 458820 459740 D hypothetical protein 458820..459740 Mycobacterium marinum M 6224641 YP_001848716.1 CDS MMAR_0394 NC_010612.1 459763 460440 R hypothetical protein complement(459763..460440) Mycobacterium marinum M 6224642 YP_001848717.1 CDS MMAR_0395 NC_010612.1 460437 461606 R hypothetical protein complement(460437..461606) Mycobacterium marinum M 6224643 YP_001848718.1 CDS MMAR_0396 NC_010612.1 461708 462877 D acyl-CoA transferase 461708..462877 Mycobacterium marinum M 6224644 YP_001848719.1 CDS MMAR_0397 NC_010612.1 463020 463568 D hypothetical protein 463020..463568 Mycobacterium marinum M 6224645 YP_001848720.1 CDS MMAR_0398 NC_010612.1 463606 464310 D hypothetical protein 463606..464310 Mycobacterium marinum M 6224646 YP_001848721.1 CDS cyp191A3 NC_010612.1 464307 465515 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 191A3 Cyp191A3 464307..465515 Mycobacterium marinum M 6224647 YP_001848722.1 CDS MMAR_0400 NC_010612.1 465517 466485 D function unknown; probably involved in cellular metabolism; dehydrogenase 465517..466485 Mycobacterium marinum M 6224648 YP_001848723.1 CDS MMAR_0401 NC_010612.1 466482 467243 D hypothetical protein 466482..467243 Mycobacterium marinum M 6224649 YP_001848724.1 CDS MMAR_0402 NC_010612.1 467240 467974 D short chain dehydrogenase 467240..467974 Mycobacterium marinum M 6224650 YP_001848725.1 CDS MMAR_0403 NC_010612.1 467971 469476 D function unknown, probably involved in cellular metabolism; monooxygenase 467971..469476 Mycobacterium marinum M 6224651 YP_001848726.1 CDS lipW NC_010612.1 469473 470414 D function unknown, lipolytic enzyme probably involved in cellular metabolism; esterase LipW 469473..470414 Mycobacterium marinum M 6224652 YP_001848727.1 CDS adhE NC_010612.1 470419 471561 R dehydrogeneses a alcohol (oxido-reduction) [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-type alcohol dehydrogenase AdhE complement(470419..471561) Mycobacterium marinum M 6224653 YP_001848728.1 CDS MMAR_0406 NC_010612.1 471564 472037 D hypothetical protein 471564..472037 Mycobacterium marinum M 6224654 YP_001848729.1 CDS MMAR_0407 NC_010612.1 472089 472550 D hypothetical protein 472089..472550 Mycobacterium marinum M 6224655 YP_001848730.1 CDS MMAR_0408 NC_010612.1 472575 473267 R possibly involved in transcriptional mechanism; GntR family transcriptional regulator complement(472575..473267) Mycobacterium marinum M 6224656 YP_001848731.1 CDS fadD5 NC_010612.1 473427 475076 D function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD5 473427..475076 Mycobacterium marinum M 6224657 YP_001848732.1 CDS yrbE1A NC_010612.1 475292 476095 D integral membrane protein YrbE1A 475292..476095 Mycobacterium marinum M 6224658 YP_001848733.1 CDS yrbE1B NC_010612.1 476097 476966 D integral membrane protein YrbE1B 476097..476966 Mycobacterium marinum M 6224659 YP_001848734.1 CDS mce1A NC_010612.1 476971 478275 D function unknown, but thought to be involved in host cell invasion (entry and survival inside macrophages); MCE-family protein Mce1A 476971..478275 Mycobacterium marinum M 6224660 YP_001848735.1 CDS mce1B NC_010612.1 478272 479312 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce1B 478272..479312 Mycobacterium marinum M 6224661 YP_001848736.1 CDS mce1C NC_010612.1 479309 480874 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce1C 479309..480874 Mycobacterium marinum M 6224662 YP_001848737.1 CDS mce1D NC_010612.1 480871 482478 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce1D 480871..482478 Mycobacterium marinum M 6224663 YP_001848738.1 CDS lprK NC_010612.1 482475 483701 D function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein LprK 482475..483701 Mycobacterium marinum M 6224664 YP_001848739.1 CDS mce1F NC_010612.1 483695 485248 D function unknown, but thought involved in host cell invasion; MCE-family protein Mce1F 483695..485248 Mycobacterium marinum M 6224665 YP_001848740.1 CDS MMAR_0418 NC_010612.1 485341 486021 D Mce associated membrane protein 485341..486021 Mycobacterium marinum M 6224666 YP_001848741.1 CDS MMAR_0419 NC_010612.1 486018 487007 D Mce associated transmembrane protein 486018..487007 Mycobacterium marinum M 6224667 YP_001848742.1 CDS MMAR_0420 NC_010612.1 487004 487561 D Mce associated protein 487004..487561 Mycobacterium marinum M 6224668 YP_001848743.1 CDS MMAR_0421 NC_010612.1 487528 488349 D Mce associated membrane protein 487528..488349 Mycobacterium marinum M 6224669 YP_001848744.1 CDS lprO NC_010612.1 488417 489562 R lipoprotein LprO complement(488417..489562) Mycobacterium marinum M 6224670 YP_001848745.1 CDS MMAR_0423 NC_010612.1 489608 490981 R transmembrane protein complement(489608..490981) Mycobacterium marinum M 6224671 YP_001848746.1 CDS MMAR_0424 NC_010612.1 491031 491756 R hypothetical protein complement(491031..491756) Mycobacterium marinum M 6224672 YP_001848747.1 CDS MMAR_0425 NC_010612.1 491956 493383 R hypothetical protein complement(491956..493383) Mycobacterium marinum M 6224673 YP_001848748.1 CDS sigG NC_010612.1 493386 494417 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70 complement(493386..494417) Mycobacterium marinum M 6224674 YP_001848749.1 CDS MMAR_0427 NC_010612.1 494479 495318 D function unknown, probably involved in cellular metabolism; lysophospholipase 494479..495318 Mycobacterium marinum M 6224675 YP_001848750.1 CDS MMAR_0428 NC_010612.1 495365 496114 D hypothetical protein 495365..496114 Mycobacterium marinum M 6224676 YP_001848751.1 CDS MMAR_0429 NC_010612.1 496111 496635 D function unknown, probably involved in a cellular metabolism; hypothetical protein 496111..496635 Mycobacterium marinum M 6224677 YP_001848752.1 CDS bglS NC_010612.1 496632 498767 D possibly involved in degradation [catalytic activity: hydrolysis of terminal, non-reducing beta-D- glucose residues with release of beta-D-glucose]; beta-glucosidase BglS 496632..498767 Mycobacterium marinum M 6224678 YP_001848753.1 CDS MMAR_0431 NC_010612.1 499089 502493 R PE-PGRS family protein complement(499089..502493) Mycobacterium marinum M 6224679 YP_001848754.1 CDS ilvD NC_010612.1 502719 504413 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(502719..504413) Mycobacterium marinum M 6224680 YP_001848755.1 CDS MMAR_0433 NC_010612.1 504553 504843 D hypothetical protein 504553..504843 Mycobacterium marinum M 6224681 YP_001848756.1 CDS MMAR_0434 NC_010612.1 504961 506217 D function unknown, possibly involved in transport of drug across the membrane; integral membrane protein 504961..506217 Mycobacterium marinum M 6224682 YP_001848757.1 CDS MMAR_0435 NC_010612.1 506337 507362 D secretory protein 506337..507362 Mycobacterium marinum M 6224683 YP_001848758.1 CDS MMAR_0436 NC_010612.1 507560 508156 D possibly involved in transcriptional mechanism; transcriptional regulatory protein 507560..508156 Mycobacterium marinum M 6224684 YP_001848759.1 CDS MMAR_0437 NC_010612.1 508143 510380 D function unknown; probably involved in cellular metabolism; oxidoreductase 508143..510380 Mycobacterium marinum M 6224685 YP_001848760.1 CDS MMAR_0438 NC_010612.1 510437 512431 R function unknown, hydrolyzes peptides and/or proteins; zinc metalloprotease complement(510437..512431) Mycobacterium marinum M 6224686 YP_001848761.1 CDS MMAR_0439 NC_010612.1 512474 513121 D hypothetical protein 512474..513121 Mycobacterium marinum M 6224687 YP_001848762.1 CDS MMAR_0440 NC_010612.1 513118 513807 D transmembrane protein 513118..513807 Mycobacterium marinum M 6224688 YP_001848763.1 CDS MMAR_0441 NC_010612.1 513794 514333 R hypothetical protein complement(513794..514333) Mycobacterium marinum M 6224689 YP_001848764.1 CDS mmpL11 NC_010612.1 514330 517347 R function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL11 complement(514330..517347) Mycobacterium marinum M 6224690 YP_001848765.1 CDS MMAR_0443 NC_010612.1 517702 518211 D exported protein 517702..518211 Mycobacterium marinum M 6224691 YP_001848766.1 CDS MMAR_0444 NC_010612.1 518213 519430 R transmembrane protein complement(518213..519430) Mycobacterium marinum M 6224692 YP_001848767.1 CDS MMAR_0445 NC_010612.1 519613 520782 D transmembrane protein 519613..520782 Mycobacterium marinum M 6224693 YP_001848768.1 CDS mmpL3 NC_010612.1 520843 523725 R function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL3 complement(520843..523725) Mycobacterium marinum M 6224694 YP_001848769.1 CDS MMAR_0447 NC_010612.1 523831 524568 R hypothetical protein complement(523831..524568) Mycobacterium marinum M 6224695 YP_001848770.1 CDS trmB NC_010612.1 524606 525514 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(524606..525514) Mycobacterium marinum M 6224696 YP_001848771.1 CDS MMAR_0449 NC_010612.1 525604 526716 D hypothetical protein 525604..526716 Mycobacterium marinum M 6224697 YP_001848772.1 CDS MMAR_0450 NC_010612.1 526713 528266 D hypothetical protein 526713..528266 Mycobacterium marinum M 6224698 YP_001848773.1 CDS pckA NC_010612.1 528469 530298 D catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 528469..530298 Mycobacterium marinum M 6224699 YP_001848774.1 CDS fadD4 NC_010612.1 530308 531831 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 530308..531831 Mycobacterium marinum M 6224700 YP_001848775.1 CDS echA8_4 NC_010612.1 531834 532802 D oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_4 531834..532802 Mycobacterium marinum M 6224701 YP_001848776.1 CDS MMAR_0454 NC_010612.1 532837 533238 R hypothetical protein complement(532837..533238) Mycobacterium marinum M 6224702 YP_001848777.1 CDS fadE3_2 NC_010612.1 533349 534521 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE3_2 complement(533349..534521) Mycobacterium marinum M 6224703 YP_001848778.1 CDS MMAR_0456 NC_010612.1 534577 535584 D hypothetical protein 534577..535584 Mycobacterium marinum M 6224704 YP_001848779.1 CDS MMAR_0459 NC_010612.1 536820 538121 D hypothetical protein 536820..538121 Mycobacterium marinum M 6224706 YP_001848780.1 CDS MMAR_0460 NC_010612.1 538398 539141 D hypothetical protein 538398..539141 Mycobacterium marinum M 6224707 YP_001848781.1 CDS MMAR_0461 NC_010612.1 539138 540484 D hypothetical protein 539138..540484 Mycobacterium marinum M 6224708 YP_001848782.1 CDS MMAR_0462 NC_010612.1 540486 541004 D hypothetical protein 540486..541004 Mycobacterium marinum M 6224709 YP_001848783.1 CDS lipC NC_010612.1 541118 542338 D function unknown, lipolytic enzyme probably involved in cellular metabolism; esterase LipC 541118..542338 Mycobacterium marinum M 6224710 YP_001848784.1 CDS MMAR_0464 NC_010612.1 542383 543822 D hypothetical protein 542383..543822 Mycobacterium marinum M 6224711 YP_001848785.1 CDS echA1 NC_010612.1 543819 544601 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 543819..544601 Mycobacterium marinum M 6224712 YP_001848786.1 CDS MMAR_0466 NC_010612.1 544700 546187 D function unknown, but involved in lipid degradation; long-chain-fatty-acid-CoA ligase 544700..546187 Mycobacterium marinum M 6224713 YP_001848787.1 CDS MMAR_0467 NC_010612.1 546184 546480 D hypothetical protein 546184..546480 Mycobacterium marinum M 6224714 YP_001848788.1 CDS MMAR_0468 NC_010612.1 547031 548785 D function unknown, but involvement in lipid degradation; fatty-acid-CoA ligase 547031..548785 Mycobacterium marinum M 6224715 YP_001848789.1 CDS MMAR_0469 NC_010612.1 548897 553561 D involved in peptide synthesis and/or lipid metabolism; peptide synthetase 548897..553561 Mycobacterium marinum M 6224716 YP_001848790.1 CDS MMAR_0470 NC_010612.1 553639 554259 R possibly involved in transcriptional mechanism; transcriptional regulatory protein complement(553639..554259) Mycobacterium marinum M 6224717 YP_001848791.1 CDS MMAR_0471 NC_010612.1 554570 555385 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 554570..555385 Mycobacterium marinum M 6224718 YP_001848792.1 CDS MMAR_0472 NC_010612.1 555450 556916 R thought to oxidize a wide variety of aliphatic and aromatic aldehydes; aldehyde dehydrogenase complement(555450..556916) Mycobacterium marinum M 6224719 YP_001848793.1 CDS MMAR_0473 NC_010612.1 556961 557728 R causes methylation; methyltransferase complement(556961..557728) Mycobacterium marinum M 6224720 YP_001848794.1 CDS MMAR_0474 NC_010612.1 557784 558947 D function unknown, contains a glycosyltransferase domain (cell envelope biogenesis, outer membrane); glycosyltransferase 557784..558947 Mycobacterium marinum M 6224721 YP_001848795.1 CDS MMAR_0475 NC_010612.1 558957 560756 R transmembrane protein complement(558957..560756) Mycobacterium marinum M 6224722 YP_001848796.1 CDS MMAR_0476 NC_010612.1 560767 562047 R hypothetical protein complement(560767..562047) Mycobacterium marinum M 6224723 YP_001848797.1 CDS MMAR_0477 NC_010612.1 562227 563393 D function unknown, probably involved in cellular metabolism; integral membrane acyltransferase 562227..563393 Mycobacterium marinum M 6224724 YP_001848798.1 CDS MMAR_0478 NC_010612.1 563405 565432 R function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection; PE-PGRS family protein complement(563405..565432) Mycobacterium marinum M 6224725 YP_001848799.1 CDS MMAR_0479 NC_010612.1 565698 565994 R hypothetical protein complement(565698..565994) Mycobacterium marinum M 6224726 YP_001848800.1 CDS MMAR_0480 NC_010612.1 565995 566288 R hypothetical protein complement(565995..566288) Mycobacterium marinum M 6224727 YP_001848801.1 CDS MMAR_0481 NC_010612.1 566639 566908 R hypothetical protein complement(566639..566908) Mycobacterium marinum M 6224728 YP_001848802.1 CDS MMAR_0482 NC_010612.1 566893 568008 R hypothetical protein complement(566893..568008) Mycobacterium marinum M 6224729 YP_001848803.1 CDS MMAR_0483 NC_010612.1 568011 568337 R hypothetical protein complement(568011..568337) Mycobacterium marinum M 6224730 YP_001848804.1 CDS MMAR_0484 NC_010612.1 568627 569241 R hypothetical protein complement(568627..569241) Mycobacterium marinum M 6224731 YP_001848805.1 CDS MMAR_5555 NC_010612.1 571687 572736 R PE-PGRS family protein complement(571687..572736) Mycobacterium marinum M 6224733 YP_001848806.1 CDS php NC_010612.1 572917 573897 R enzymatic activity is not yet known [catalytic activity: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol]; phosphotriesterase PHP complement(572917..573897) Mycobacterium marinum M 6224734 YP_001848807.1 CDS fadE4 NC_010612.1 574239 575945 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE4 574239..575945 Mycobacterium marinum M 6224735 YP_001848808.1 CDS MMAR_0489 NC_010612.1 576044 576715 D involved in transcriptional mechanism; TetR family transcriptional regulator 576044..576715 Mycobacterium marinum M 6224736 YP_001848809.1 CDS gabD1 NC_010612.1 576837 578213 R NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase complement(576837..578213) Mycobacterium marinum M 6224737 YP_001848810.1 CDS MMAR_0491 NC_010612.1 578650 579834 D PPE family protein 578650..579834 Mycobacterium marinum M 6224738 YP_001848811.1 CDS MMAR_0492 NC_010612.1 580024 582498 D PE-PGRS family protein 580024..582498 Mycobacterium marinum M 6224739 YP_001848812.1 CDS MMAR_0493 NC_010612.1 582580 584004 R hypothetical protein complement(582580..584004) Mycobacterium marinum M 6224740 YP_001848813.1 CDS glpQ2 NC_010612.1 584129 584917 R glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate]; glycerophosphoryl diester phosphodiesterase complement(584129..584917) Mycobacterium marinum M 6224741 YP_001848814.1 CDS MMAR_0495 NC_010612.1 585057 585614 D hypothetical protein 585057..585614 Mycobacterium marinum M 6224742 YP_001848815.1 CDS MMAR_0496 NC_010612.1 585618 589796 R transmembrane protein complement(585618..589796) Mycobacterium marinum M 6224743 YP_001848816.1 CDS MMAR_0497 NC_010612.1 589885 590058 R small secreted protein complement(589885..590058) Mycobacterium marinum M 6224744 YP_001848817.1 CDS MMAR_0498 NC_010612.1 590127 590384 R putative small secreted protein complement(590127..590384) Mycobacterium marinum M 6224745 YP_001848818.1 CDS lpqI NC_010612.1 590488 591681 D lipoprotein LpqI 590488..591681 Mycobacterium marinum M 6224746 YP_001848819.1 CDS MMAR_0500 NC_010612.1 591768 592394 D possibly involved in transcriptional mechanism; TetR family transcriptional regulator 591768..592394 Mycobacterium marinum M 6224747 YP_001848820.1 CDS MMAR_0501 NC_010612.1 592522 593826 D function unknown, possibly ion channel involved in transport of chloride across the membrane; transmembrane protein 592522..593826 Mycobacterium marinum M 6224748 YP_001848821.1 CDS MMAR_0502 NC_010612.1 593838 594689 R hypothetical protein complement(593838..594689) Mycobacterium marinum M 6224749 YP_001848822.1 CDS fabG NC_010612.1 594708 596072 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(594708..596072) Mycobacterium marinum M 6224750 YP_001848823.1 CDS fadA2 NC_010612.1 596242 597567 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 596242..597567 Mycobacterium marinum M 6224751 YP_001848824.1 CDS fadE5 NC_010612.1 597865 599700 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE5 complement(597865..599700) Mycobacterium marinum M 6224752 YP_001848825.1 CDS MMAR_0506 NC_010612.1 600242 600730 D function unknown, probably involved in cellular metabolism; oxidoreductase 600242..600730 Mycobacterium marinum M 6224753 YP_001848826.1 CDS MMAR_0507 NC_010612.1 600855 601163 D hypothetical protein 600855..601163 Mycobacterium marinum M 6224754 YP_001848827.1 CDS MMAR_0508 NC_010612.1 601170 602420 D integral membrane protein 601170..602420 Mycobacterium marinum M 6224755 YP_001848828.1 CDS MMAR_0509 NC_010612.1 602461 602619 R hypothetical protein complement(602461..602619) Mycobacterium marinum M 6224756 YP_001848829.1 CDS sdhB_1 NC_010612.1 602667 603413 R catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit complement(602667..603413) Mycobacterium marinum M 6224757 YP_001848830.1 CDS sdhA NC_010612.1 603413 605341 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit complement(603413..605341) Mycobacterium marinum M 6224758 YP_001848831.1 CDS MMAR_0512 NC_010612.1 605388 606209 R could be involved in interconversion of fumarate and succinate (aerobic respiration). this hydrophobic component may be required to anchor the catalytic components of the succinate dehydrogenase complex to the cytoplasmic membrane; succinate dehydrogenase (membrane anchor subunit) complement(605388..606209) Mycobacterium marinum M 6224759 YP_001848832.1 CDS MMAR_0513 NC_010612.1 606288 606584 R In M. tuberculosis this gene is down regulated by HspR|Rv0353; hypothetical protein complement(606288..606584) Mycobacterium marinum M 6224760 YP_001848833.1 CDS MMAR_0514 NC_010612.1 606700 607470 D PEP phosphonomutase 606700..607470 Mycobacterium marinum M 6224761 YP_001848834.1 CDS hsp NC_010612.1 607545 608003 R thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR; heat shock protein Hsp complement(607545..608003) Mycobacterium marinum M 6224762 YP_001848835.1 CDS nirB NC_010612.1 608237 610795 D involved in nitrate assimilation (denitrification) (at the second step). this enzyme is a fad flavoprotein that also contains a siroheme and one 2Fe-2S iron-sulfur center [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O.]; nitrite reductase NAD(P)H large subunit 608237..610795 Mycobacterium marinum M 6224763 YP_001848836.1 CDS nirD NC_010612.1 610821 611177 D involved in nitrate assimilation (denitrification); required for activity of the reductase [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O.]; nitrite reductase [NAD(P)H] small subunit NirD 610821..611177 Mycobacterium marinum M 6224764 YP_001848837.1 CDS MMAR_0518 NC_010612.1 611314 611769 R hypothetical protein complement(611314..611769) Mycobacterium marinum M 6224765 YP_001848838.1 CDS MMAR_0519 NC_010612.1 611826 612587 R hypothetical protein complement(611826..612587) Mycobacterium marinum M 6224766 YP_001848839.1 CDS MMAR_0520 NC_010612.1 612578 613729 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein complement(612578..613729) Mycobacterium marinum M 6224767 YP_001848840.1 CDS narK3_2 NC_010612.1 613808 615211 R involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK3 complement(613808..615211) Mycobacterium marinum M 6224768 YP_001848841.1 CDS aac NC_010612.1 615441 615986 R confers resistance to aminoglycosides (gentamicin, tobramycin, dibekacin, netilmicin, and 6'-N- ethylnetilmicin); aminoglycoside 2'-N-acetyltransferase Aac complement(615441..615986) Mycobacterium marinum M 6224769 YP_001848842.1 CDS MMAR_0523 NC_010612.1 616013 616882 R urea amidolyase-related protein complement(616013..616882) Mycobacterium marinum M 6224770 YP_001848843.1 CDS MMAR_0524 NC_010612.1 616898 617569 R hypothetical protein complement(616898..617569) Mycobacterium marinum M 6224771 YP_001848844.1 CDS MMAR_0525 NC_010612.1 617682 618674 R thought to be involved in iron transport across the membrane (import); periplasmic iron-transport lipoprotein complement(617682..618674) Mycobacterium marinum M 6224772 YP_001848845.1 CDS narU NC_010612.1 618928 620325 D involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarU 618928..620325 Mycobacterium marinum M 6224773 YP_001848846.1 CDS MMAR_0527 NC_010612.1 620326 621588 R hypothetical protein complement(620326..621588) Mycobacterium marinum M 6224774 YP_001848847.1 CDS fadD2 NC_010612.1 621656 623329 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 621656..623329 Mycobacterium marinum M 6224775 YP_001848848.1 CDS MMAR_0529 NC_010612.1 623773 625134 R hypothetical protein complement(623773..625134) Mycobacterium marinum M 6224776 YP_001848849.1 CDS fadE6 NC_010612.1 625361 627547 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE6 complement(625361..627547) Mycobacterium marinum M 6224777 YP_001848850.1 CDS serA3 NC_010612.1 627604 628566 R involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase complement(627604..628566) Mycobacterium marinum M 6224778 YP_001848851.1 CDS MMAR_0532 NC_010612.1 628563 629561 R hypothetical protein complement(628563..629561) Mycobacterium marinum M 6224779 YP_001848852.1 CDS MMAR_0533 NC_010612.1 629698 630306 R could be involved in transcriptional mechanism; transcriptional regulatory protein complement(629698..630306) Mycobacterium marinum M 6224780 YP_001848853.1 CDS MMAR_0534 NC_010612.1 630397 630978 D hypothetical protein 630397..630978 Mycobacterium marinum M 6224781 YP_001848854.1 CDS MMAR_0535 NC_010612.1 630985 631533 D hypothetical protein 630985..631533 Mycobacterium marinum M 6224782 YP_001848855.1 CDS MMAR_0536 NC_010612.1 631487 632143 R could be involved in transcriptional mechanism; TetR family transcriptional regulator complement(631487..632143) Mycobacterium marinum M 6224783 YP_001848856.1 CDS MMAR_0537 NC_010612.1 632268 633170 D hypothetical protein 632268..633170 Mycobacterium marinum M 6224784 YP_001848857.1 CDS MMAR_0538 NC_010612.1 633414 634982 D PPE family protein 633414..634982 Mycobacterium marinum M 6224785 YP_001848858.1 CDS MMAR_0539 NC_010612.1 635001 635906 D O-methyltransferase 635001..635906 Mycobacterium marinum M 6224786 YP_001848859.1 CDS MMAR_0540 NC_010612.1 636034 636183 D hypothetical protein 636034..636183 Mycobacterium marinum M 6224787 YP_001848860.1 CDS MMAR_0541 NC_010612.1 636348 638210 D hypothetical protein 636348..638210 Mycobacterium marinum M 6224788 YP_001848861.1 CDS MMAR_0542 NC_010612.1 638207 639808 D hypothetical protein 638207..639808 Mycobacterium marinum M 6224789 YP_001848862.1 CDS MMAR_0543 NC_010612.1 639805 643806 D hypothetical protein 639805..643806 Mycobacterium marinum M 6224790 YP_001848863.1 CDS MMAR_0544 NC_010612.1 643809 644117 D PE family protein 643809..644117 Mycobacterium marinum M 6224791 YP_001848864.1 CDS MMAR_0545 NC_010612.1 644120 645673 D PPE family protein 644120..645673 Mycobacterium marinum M 6224792 YP_001848865.1 CDS esxG NC_010612.1 645710 646003 D EsaT-6 like protein EsxG 645710..646003 Mycobacterium marinum M 6224793 YP_001848866.1 CDS esxH NC_010612.1 646032 646322 D EsaT-6 like protein EsxH 646032..646322 Mycobacterium marinum M 6224794 YP_001848867.1 CDS MMAR_0548 NC_010612.1 646331 647227 D hypothetical protein 646331..647227 Mycobacterium marinum M 6224795 YP_001848868.1 CDS MMAR_0549 NC_010612.1 647299 648717 D transmembrane protein 647299..648717 Mycobacterium marinum M 6224796 YP_001848869.1 CDS mycP3 NC_010612.1 648714 650138 D thought to have proteolytic activity; membrane-anchored mycosin MycP3 648714..650138 Mycobacterium marinum M 6224797 YP_001848870.1 CDS MMAR_0551 NC_010612.1 650128 651141 D transmembrane protein 650128..651141 Mycobacterium marinum M 6224798 YP_001848871.1 CDS MMAR_0552 NC_010612.1 651128 652348 R hypothetical protein complement(651128..652348) Mycobacterium marinum M 6224799 YP_001848872.1 CDS tam NC_010612.1 652505 653296 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 652505..653296 Mycobacterium marinum M 6224800 YP_001848873.1 CDS MMAR_0554 NC_010612.1 653314 654711 R function unknown, probably involved in cellular metabolism; sulfatase complement(653314..654711) Mycobacterium marinum M 6224801 YP_001848874.1 CDS MMAR_0555 NC_010612.1 654778 655428 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(654778..655428) Mycobacterium marinum M 6224802 YP_001848875.1 CDS MMAR_0556 NC_010612.1 655616 655873 D hypothetical protein 655616..655873 Mycobacterium marinum M 6224804 YP_001848876.1 CDS MMAR_0557 NC_010612.1 655857 656339 R hypothetical protein complement(655857..656339) Mycobacterium marinum M 6224805 YP_001848877.1 CDS MMAR_0558 NC_010612.1 656396 657064 D hypothetical protein 656396..657064 Mycobacterium marinum M 6224806 YP_001848878.1 CDS MMAR_0559 NC_010612.1 657170 657826 D hypothetical protein 657170..657826 Mycobacterium marinum M 6224807 YP_001848879.1 CDS MMAR_0560 NC_010612.1 657835 658323 R hypothetical protein complement(657835..658323) Mycobacterium marinum M 6224808 YP_001848880.1 CDS MMAR_0561 NC_010612.1 658401 659630 D hypothetical protein 658401..659630 Mycobacterium marinum M 6224809 YP_001848881.1 CDS MMAR_0562 NC_010612.1 659783 661663 D hypothetical protein 659783..661663 Mycobacterium marinum M 6224810 YP_001848882.1 CDS MMAR_0563 NC_010612.1 661885 663321 D hypothetical protein 661885..663321 Mycobacterium marinum M 6224811 YP_001848883.1 CDS MMAR_0564 NC_010612.1 663389 663775 D hypothetical protein 663389..663775 Mycobacterium marinum M 6224812 YP_001848884.1 CDS MMAR_0565 NC_010612.1 663823 664542 R hypothetical protein complement(663823..664542) Mycobacterium marinum M 6224813 YP_001848885.1 CDS MMAR_0566 NC_010612.1 664606 665625 D hypothetical protein 664606..665625 Mycobacterium marinum M 6224814 YP_001848886.1 CDS MMAR_0567 NC_010612.1 665837 666715 D possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls; beta-1,3-glucanase 665837..666715 Mycobacterium marinum M 6224815 YP_001848887.1 CDS MMAR_0568 NC_010612.1 666815 667474 D could be involved in the catabolism of catechol to succinate- and acetyl-CoA in the beta-ketoadipate pathway (at the third step) [catalytic activity: 2,5-dihydro-5- oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate]; muconolactone isomerase 666815..667474 Mycobacterium marinum M 6224816 YP_001848888.1 CDS MMAR_0569 NC_010612.1 667509 669005 D hypothetical protein 667509..669005 Mycobacterium marinum M 6224817 YP_001848889.1 CDS MMAR_0570 NC_010612.1 668953 670395 R phosphorylation of carbohydrates; carbohydrate kinase complement(668953..670395) Mycobacterium marinum M 6224818 YP_001848890.1 CDS MMAR_0571 NC_010612.1 670445 671848 R carbohydrate metabolism; mannitol dehydrogenase complement(670445..671848) Mycobacterium marinum M 6224819 YP_001848891.1 CDS MMAR_0572 NC_010612.1 672368 673837 D PE-PGRS family protein 672368..673837 Mycobacterium marinum M 6224820 YP_001848892.1 CDS MMAR_0573 NC_010612.1 673937 675019 D function unknown but may have hydrolytic activity; hypothetical protein 673937..675019 Mycobacterium marinum M 6224821 YP_001848893.1 CDS MMAR_0574 NC_010612.1 675134 676234 R hypothetical protein complement(675134..676234) Mycobacterium marinum M 6224822 YP_001848894.1 CDS MMAR_0575 NC_010612.1 676332 677102 R hydrolytic protein complement(676332..677102) Mycobacterium marinum M 6224823 YP_001848895.1 CDS MMAR_0576 NC_010612.1 677132 679717 R function unknown; probably involved in cellular metabolism; monooxygenase complement(677132..679717) Mycobacterium marinum M 6224824 YP_001848896.1 CDS MMAR_0577 NC_010612.1 679836 681011 R function unknown; belongs to the major facilitator superfamily (MFS); integral membrane transport protein complement(679836..681011) Mycobacterium marinum M 6224825 YP_001848897.1 CDS aroB_1 NC_010612.1 681544 682746 D 3-dehydroquinate (DHQ) synthase catalyses the formation of dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate. this reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids; 3-dehydroquinate synthase 681544..682746 Mycobacterium marinum M 6224826 YP_001848898.1 CDS MMAR_0579 NC_010612.1 682746 683504 D dehydrogenase 682746..683504 Mycobacterium marinum M 6224827 YP_001848899.1 CDS MMAR_0580 NC_010612.1 683515 684183 D hydrolase 683515..684183 Mycobacterium marinum M 6224828 YP_001848900.1 CDS MMAR_0581 NC_010612.1 684190 685191 D domain homology to NagC, transcriptional regulator/sugar kinase [transcription / carbohydrate transport and metabolism]; glucose kinase 684190..685191 Mycobacterium marinum M 6224829 YP_001848901.1 CDS MMAR_0582 NC_010612.1 685188 686297 D function unknown; similarity to cyclitol dehydrogenase from actinoplanes sp. 50/110; dehydrogenase 685188..686297 Mycobacterium marinum M 6224830 YP_001848902.1 CDS MMAR_0583 NC_010612.1 686294 687079 D epimerase 686294..687079 Mycobacterium marinum M 6224831 YP_001848903.1 CDS MMAR_0584 NC_010612.1 687271 688077 D hypothetical protein 687271..688077 Mycobacterium marinum M 6224832 YP_001848904.1 CDS MMAR_0585 NC_010612.1 688162 688371 R hypothetical protein complement(688162..688371) Mycobacterium marinum M 6224833 YP_001848905.1 CDS MMAR_0586 NC_010612.1 688441 689655 R hypothetical protein complement(688441..689655) Mycobacterium marinum M 6224834 YP_001848906.1 CDS MMAR_0587 NC_010612.1 690319 691065 D function unknown; probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 690319..691065 Mycobacterium marinum M 6224835 YP_001848907.1 CDS MMAR_0588 NC_010612.1 691118 691279 D hypothetical protein 691118..691279 Mycobacterium marinum M 6224836 YP_001848908.1 CDS pinR NC_010612.1 691276 691878 D possible phage recombinase; site-specific recombinase PinR 691276..691878 Mycobacterium marinum M 6224837 YP_001848909.1 CDS MMAR_0590 NC_010612.1 691875 692183 D hypothetical protein 691875..692183 Mycobacterium marinum M 6224838 YP_001848910.1 CDS MMAR_0593 NC_010612.1 693949 695250 R hypothetical protein complement(693949..695250) Mycobacterium marinum M 6224842 YP_001848911.1 CDS MMAR_0594 NC_010612.1 695247 695909 R hypothetical protein complement(695247..695909) Mycobacterium marinum M 6224843 YP_001848912.1 CDS MMAR_0595 NC_010612.1 696096 696875 R involved in transcriptional mechanism; transcriptional regulatory protein complement(696096..696875) Mycobacterium marinum M 6224845 YP_001848913.1 CDS MMAR_0596 NC_010612.1 697088 698422 D integral membrane transport protein 697088..698422 Mycobacterium marinum M 6224846 YP_001848914.1 CDS MMAR_0597 NC_010612.1 698509 698925 D hypothetical protein 698509..698925 Mycobacterium marinum M 6224847 YP_001848915.1 CDS pcp NC_010612.1 698949 699617 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 698949..699617 Mycobacterium marinum M 6224848 YP_001848916.1 CDS MMAR_0599 NC_010612.1 699820 700488 D may be exported; hypothetical protein 699820..700488 Mycobacterium marinum M 6224849 YP_001848917.1 CDS dcd NC_010612.1 700534 701106 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 700534..701106 Mycobacterium marinum M 6224850 YP_001848918.1 CDS MMAR_0601 NC_010612.1 701196 702881 D hypothetical protein 701196..702881 Mycobacterium marinum M 6224851 YP_001848919.1 CDS MMAR_0602 NC_010612.1 703037 704563 D hypothetical protein 703037..704563 Mycobacterium marinum M 6224852 YP_001848920.1 CDS udgA NC_010612.1 704640 705974 D UDP-glucose dehydrogenase UdgA 704640..705974 Mycobacterium marinum M 6224853 YP_001848921.1 CDS MMAR_0604 NC_010612.1 706036 706791 D hypothetical protein 706036..706791 Mycobacterium marinum M 6224854 YP_001848922.1 CDS MMAR_0605 NC_010612.1 706827 707201 D hypothetical protein 706827..707201 Mycobacterium marinum M 6224855 YP_001848923.1 CDS rmlA NC_010612.1 707231 708097 D dTDP-L-rhamnose biosynthesis within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis [catalytic activity: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose]; alpha-D-glucose-1-phosphate thymidylyl- transferase, RmlA 707231..708097 Mycobacterium marinum M 6224856 YP_001848924.1 CDS MMAR_0607 NC_010612.1 708134 709567 R Ortholog of PE_PGRS9; PE-PGRS family protein complement(708134..709567) Mycobacterium marinum M 6224857 YP_001848925.1 CDS MMAR_0608 NC_010612.1 709749 711179 R PE-PGRS family protein complement(709749..711179) Mycobacterium marinum M 6224858 YP_001848926.1 CDS MMAR_0609 NC_010612.1 711571 714756 D function unknown, member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins; PE-PGRS family protein 711571..714756 Mycobacterium marinum M 6224859 YP_001848927.1 CDS aspC NC_010612.1 714850 716139 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT complement(714850..716139) Mycobacterium marinum M 6224860 YP_001848928.1 CDS MMAR_0611 NC_010612.1 716170 719127 R iron-sulfur-binding reductase complement(716170..719127) Mycobacterium marinum M 6224861 YP_001848929.1 CDS MMAR_0612 NC_010612.1 719257 721710 R involved in transcriptional mechanism; transcriptional regulatory protein complement(719257..721710) Mycobacterium marinum M 6224862 YP_001848930.1 CDS MMAR_0613 NC_010612.1 721914 722453 D hypothetical protein 721914..722453 Mycobacterium marinum M 6224863 YP_001848931.1 CDS iniB NC_010612.1 722730 725729 D function unknown function but ortholog in M.tuberculosis induced by isoniazid and ethionamide; membrane protein, IniB 722730..725729 Mycobacterium marinum M 6224864 YP_001848932.1 CDS iniA NC_010612.1 725830 727683 D in M. tuberculosis H37Rv this gene is induced by isoniazid (INH) or ethionamide treatment) (see wilson et al., 1999); hypothetical protein 725830..727683 Mycobacterium marinum M 6224865 YP_001848933.1 CDS iniC NC_010612.1 727680 729161 D in M. tuberculosis H37Rv IniC is an isoniazid- inducible gene; isoniazid inductible protein IniC 727680..729161 Mycobacterium marinum M 6224866 YP_001848934.1 CDS MMAR_0617 NC_010612.1 729166 731004 R hypothetical protein complement(729166..731004) Mycobacterium marinum M 6224867 YP_001848935.1 CDS MMAR_0618 NC_010612.1 731096 731641 R hypothetical protein complement(731096..731641) Mycobacterium marinum M 6224868 YP_001848936.1 CDS MMAR_0619 NC_010612.1 731749 732330 R hypothetical protein complement(731749..732330) Mycobacterium marinum M 6224869 YP_001848937.1 CDS lpqJ NC_010612.1 732367 732936 R lipoprotein LpqJ complement(732367..732936) Mycobacterium marinum M 6224870 YP_001848938.1 CDS coxS_3 NC_010612.1 733028 733504 R probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase small chain CoxS_3 complement(733028..733504) Mycobacterium marinum M 6224871 YP_001848939.1 CDS coxM_3 NC_010612.1 733497 734384 R aerobic-type carbon monoxide dehydrogenase subunit CoxM_3 complement(733497..734384) Mycobacterium marinum M 6224872 YP_001848940.1 CDS coxL_3 NC_010612.1 734381 736711 R aerobic-type carbon monoxide dehydrogenase subunit CoxL_3 complement(734381..736711) Mycobacterium marinum M 6224873 YP_001848941.1 CDS MMAR_0624 NC_010612.1 736871 737419 D hypothetical protein 736871..737419 Mycobacterium marinum M 6224874 YP_001848942.1 CDS MMAR_0625 NC_010612.1 737435 737812 R PE-PGRS family protein complement(737435..737812) Mycobacterium marinum M 6224875 YP_001848943.1 CDS ansP1_1 NC_010612.1 737973 739403 R involved in L-asparagine transport; L-asparagine permease AnsP1 complement(737973..739403) Mycobacterium marinum M 6224876 YP_001848944.1 CDS MMAR_0628 NC_010612.1 739684 740505 R function unknown; domain homology with alkanesulfonate_monoxygenase; monooxygenase complement(739684..740505) Mycobacterium marinum M 6224877 YP_001848945.1 CDS MMAR_0629 NC_010612.1 740539 741276 R function unknown; FabG-like enzyme; dehydrogenase complement(740539..741276) Mycobacterium marinum M 6224878 YP_001848946.1 CDS MMAR_0630 NC_010612.1 741480 742088 D transcriptional regulatory protein 741480..742088 Mycobacterium marinum M 6224879 YP_001848947.1 CDS kdpA NC_010612.1 742925 744583 D catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 742925..744583 Mycobacterium marinum M 6224880 YP_001848948.1 CDS kdpB NC_010612.1 744583 746664 D One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 744583..746664 Mycobacterium marinum M 6224881 YP_001848949.1 CDS kdpC NC_010612.1 746667 747557 D one of the components of the high-affinity ATP- driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. the C subunit may be involved in assembly of the Kdp complex. [catalytic activity: ATP + H(2)O + K(+)(out) = ADP + phosphate + K(+)(in)]; potassium-transporting ATPase subunit KdpC 746667..747557 Mycobacterium marinum M 6224882 YP_001848950.1 CDS kdpD NC_010612.1 747565 750084 D member of the two-component regulatory system KdpD/KdpE involved in the regulation of the Kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals; two-component system response phosphate sensor kinase, KdpD 747565..750084 Mycobacterium marinum M 6224883 YP_001848951.1 CDS kdpE NC_010612.1 750081 750761 D receiver domain of the two-component regulatory system Kdp/KdpE involved in the regulation of the Kdp operon; transcriptional regulatory protein KdpE 750081..750761 Mycobacterium marinum M 6224884 YP_001848952.1 CDS MMAR_0636 NC_010612.1 750981 751961 R hypothetical protein complement(750981..751961) Mycobacterium marinum M 6224885 YP_001848953.1 CDS dnaK NC_010612.1 752226 754094 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 752226..754094 Mycobacterium marinum M 6224886 YP_001848954.1 CDS grpE NC_010612.1 754091 754744 D stimulates, jointly with DnaJ, the ATPase activity of DnaK. helps to release ADP from DnaK thus allowing DnaK to recycle more efficiently. seems to be regulated negatively by HspR; GrpE protein (Hsp-70 cofactor) 754091..754744 Mycobacterium marinum M 6224887 YP_001848955.1 CDS dnaJ NC_010612.1 754802 755992 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 754802..755992 Mycobacterium marinum M 6224888 YP_001848956.1 CDS hspR NC_010612.1 755993 756379 D involved in transcriptional regulation (repression) of heat shock proteins E.G. DnaK, GrpE, DnaJ1. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock; heat shock protein transcriptional repressor HspR 755993..756379 Mycobacterium marinum M 6224889 YP_001848957.1 CDS MMAR_0641 NC_010612.1 756407 763618 R PPE family protein complement(756407..763618) Mycobacterium marinum M 6224890 YP_001848958.1 CDS MMAR_0642 NC_010612.1 763949 774499 R PPE family protein complement(763949..774499) Mycobacterium marinum M 6224891 YP_001848959.1 CDS MMAR_0643 NC_010612.1 775707 776597 R possible carbohydrate transport and metabolism; hypothetical protein complement(775707..776597) Mycobacterium marinum M 6224892 YP_001848960.1 CDS MMAR_0644 NC_010612.1 776672 777853 R function unknown, probably involved in cellular metabolism; monooxygenase complement(776672..777853) Mycobacterium marinum M 6224893 YP_001848961.1 CDS clpB NC_010612.1 778180 780726 D ATPase subunit of an intracellular ATP-dependent protease. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR; endopeptidase ATP binding protein (chain B) ClpB 778180..780726 Mycobacterium marinum M 6224894 YP_001848962.1 CDS echA8_1 NC_010612.1 780723 781553 R oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8 complement(780723..781553) Mycobacterium marinum M 6224895 YP_001848963.1 CDS MMAR_0647 NC_010612.1 781912 782766 D hypothetical protein 781912..782766 Mycobacterium marinum M 6224896 YP_001848964.1 CDS MMAR_0648 NC_010612.1 782811 783584 D function unknown, but possibly involvement in lipid metabolism; ketoacyl reductase 782811..783584 Mycobacterium marinum M 6224897 YP_001848965.1 CDS pyrE NC_010612.1 783571 784110 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 783571..784110 Mycobacterium marinum M 6224898 YP_001848966.1 CDS MMAR_0650 NC_010612.1 784121 785014 D hypothetical protein 784121..785014 Mycobacterium marinum M 6224899 YP_001848967.1 CDS MMAR_0651 NC_010612.1 785011 785655 D possibly causes methylation of RNA; RNA methyltransferase 785011..785655 Mycobacterium marinum M 6224900 YP_001848968.1 CDS secE2 NC_010612.1 785764 785979 R thought to be involved in protein transport (export); protein transport protein SecE2 complement(785764..785979) Mycobacterium marinum M 6224901 YP_001848969.1 CDS MMAR_0653 NC_010612.1 785997 786962 R possibly involved in transcriptional mechanism; LysR family transcriptional regulator complement(785997..786962) Mycobacterium marinum M 6224902 YP_001848970.1 CDS MMAR_0654 NC_010612.1 786987 788150 D hypothetical protein 786987..788150 Mycobacterium marinum M 6224903 YP_001848971.1 CDS coxM NC_010612.1 788211 789101 D function unknown; probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase medium chain CoxM 788211..789101 Mycobacterium marinum M 6224904 YP_001848972.1 CDS coxS NC_010612.1 789101 789583 D function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase small chain CoxS 789101..789583 Mycobacterium marinum M 6224905 YP_001848973.1 CDS coxL NC_010612.1 789580 791970 D function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase large chain CoxL 789580..791970 Mycobacterium marinum M 6224906 YP_001848974.1 CDS MMAR_0658 NC_010612.1 791980 792864 D hypothetical protein 791980..792864 Mycobacterium marinum M 6224907 YP_001848975.1 CDS MMAR_0659 NC_010612.1 792861 793451 D hypothetical protein 792861..793451 Mycobacterium marinum M 6224908 YP_001848976.1 CDS MMAR_0660 NC_010612.1 793452 794330 D function unknown, probably involved in cellular metabolism; membrane oxidoreductase 793452..794330 Mycobacterium marinum M 6224909 YP_001848977.1 CDS MMAR_0661 NC_010612.1 794344 795018 D function unknown, probably involved in cellular metabolism; membrane oxidoreductase 794344..795018 Mycobacterium marinum M 6224910 YP_001848978.1 CDS MMAR_0662 NC_010612.1 795025 796230 D von Willebrand factor type A domain-containing protein 795025..796230 Mycobacterium marinum M 6224911 YP_001848979.1 CDS eutC NC_010612.1 796233 797006 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(796233..797006) Mycobacterium marinum M 6224912 YP_001848980.1 CDS eutB NC_010612.1 797003 798412 R ethanolamine catabolism. catalyzes the conversion of ethanolamine to acetaldehyde in the presence of coenzyme B12 or adenosylcobalamin (AdoCbl); ethanolamine ammonia-lyase large subunit, EutB complement(797003..798412) Mycobacterium marinum M 6224913 YP_001848981.1 CDS MMAR_0665 NC_010612.1 798409 799860 R thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane; ethanolamine transporter complement(798409..799860) Mycobacterium marinum M 6224914 YP_001848982.1 CDS cya_1 NC_010612.1 800337 801662 D involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; membrane-anchored adenylyl cyclase Cya 800337..801662 Mycobacterium marinum M 6224915 YP_001848983.1 CDS MMAR_0667 NC_010612.1 801761 802876 D glycosyl hydrolase 801761..802876 Mycobacterium marinum M 6224916 YP_001848984.1 CDS MMAR_0668 NC_010612.1 802865 803557 R transmembrane protein complement(802865..803557) Mycobacterium marinum M 6224917 YP_001848985.1 CDS fba NC_010612.1 803658 804692 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 803658..804692 Mycobacterium marinum M 6224918 YP_001848986.1 CDS mgtE NC_010612.1 804824 806212 R thought to be involved in Mg2+ transport. responsible for the translocation of the substrate across the membrane; Mg2+ transport transmembrane protein MgtE complement(804824..806212) Mycobacterium marinum M 6224919 YP_001848987.1 CDS MMAR_0671 NC_010612.1 806979 807794 R hypothetical protein complement(806979..807794) Mycobacterium marinum M 6224920 YP_001848988.1 CDS MMAR_0672 NC_010612.1 807936 808358 D hypothetical protein 807936..808358 Mycobacterium marinum M 6224921 YP_001848989.1 CDS MMAR_0673 NC_010612.1 808582 809340 D hypothetical protein 808582..809340 Mycobacterium marinum M 6224922 YP_001848990.1 CDS MMAR_0674 NC_010612.1 809355 809615 D hypothetical protein 809355..809615 Mycobacterium marinum M 6224923 YP_001848991.1 CDS MMAR_0675 NC_010612.1 809619 809756 D hypothetical protein 809619..809756 Mycobacterium marinum M 6224924 YP_001848992.1 CDS MMAR_0676 NC_010612.1 809757 810731 D involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids; glycolipid sulfotransferase 809757..810731 Mycobacterium marinum M 6224925 YP_001848993.1 CDS MMAR_0677 NC_010612.1 810761 811684 R possibly involved in export of metal ions across the membrane; efflux membrane protein complement(810761..811684) Mycobacterium marinum M 6224926 YP_001848994.1 CDS MMAR_0678 NC_010612.1 811729 812499 R hypothetical protein complement(811729..812499) Mycobacterium marinum M 6224927 YP_001848995.1 CDS MMAR_0679 NC_010612.1 812519 813196 R hypothetical protein complement(812519..813196) Mycobacterium marinum M 6224928 YP_001848996.1 CDS purA NC_010612.1 813287 814585 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 813287..814585 Mycobacterium marinum M 6224929 YP_001848997.1 CDS MMAR_0681 NC_010612.1 814582 815241 D hypothetical protein 814582..815241 Mycobacterium marinum M 6224930 YP_001848998.1 CDS MMAR_0684 NC_010612.1 815627 816274 R putative regulatory protein complement(815627..816274) Mycobacterium marinum M 6224933 YP_001848999.1 CDS MMAR_0685 NC_010612.1 816586 817920 R PPE family protein complement(816586..817920) Mycobacterium marinum M 6224934 YP_001849000.1 CDS purT NC_010612.1 818393 819730 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 818393..819730 Mycobacterium marinum M 6224935 YP_001849001.1 CDS MMAR_0687 NC_010612.1 819727 820155 D contains conserved rhodanese domain superfamily, subgroup 1. this domain includes the putative rhodanese- related sulfurtransferases of several uncharacterized proteins; hypothetical protein 819727..820155 Mycobacterium marinum M 6224936 YP_001849002.1 CDS metZ NC_010612.1 820243 821481 D involved in methionine biosynthesis. converts O- succinylhomoserine into homocysteine; O-succinylhomoserine sulfhydrylase 820243..821481 Mycobacterium marinum M 6224937 YP_001849003.1 CDS ndh_1 NC_010612.1 821536 822951 R transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation; NADH dehydrogenase Ndh complement(821536..822951) Mycobacterium marinum M 6224938 YP_001849004.1 CDS MMAR_0690 NC_010612.1 823595 824785 D function unknown, but seems involved in efflux system (probably sugar or drug transport); putative transport protein 823595..824785 Mycobacterium marinum M 6224939 YP_001849005.1 CDS MMAR_0691 NC_010612.1 824795 826768 R function unknown but high domain identity with choline/carnitine o-acyltransferases; hypothetical protein complement(824795..826768) Mycobacterium marinum M 6224940 YP_001849006.1 CDS tauD_1 NC_010612.1 826765 827898 R gamma-butyrobetaine hydroxylase is a 2-oxoglutarate- dependent dioxygenase that catalyzes the hydroxylation of gamma-butyrobetaine to carnitine, the last step in the biosynthesis of carnitine from lysine. reaction catalysed: 4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) <=> 3- hydroxy-4-trimethylammoniobutanoate + succinate + CO(2); gamma-butyrobetaine hydroxylase, TauD complement(826765..827898) Mycobacterium marinum M 6224941 YP_001849007.1 CDS panD_1 NC_010612.1 827898 828386 R decarboxylation of aspartate. this is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase which requires a pyruvoyl group for its activity; aspartate decarboxylase, PanD complement(827898..828386) Mycobacterium marinum M 6224942 YP_001849008.1 CDS MMAR_0694 NC_010612.1 828383 829897 R function unknown, contains two UbiE domains: methylase involved in ubiquinone/menaquinone biosynthesis; hypothetical protein complement(828383..829897) Mycobacterium marinum M 6224943 YP_001849009.1 CDS MMAR_0695 NC_010612.1 830263 830913 R hypothetical protein complement(830263..830913) Mycobacterium marinum M 6224944 YP_001849010.1 CDS lpqK NC_010612.1 830917 832158 R lipoprotein LpqK complement(830917..832158) Mycobacterium marinum M 6224945 YP_001849011.1 CDS MMAR_0697 NC_010612.1 832208 833356 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase complement(832208..833356) Mycobacterium marinum M 6224946 YP_001849012.1 CDS fadE7 NC_010612.1 833368 834555 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE7 complement(833368..834555) Mycobacterium marinum M 6224947 YP_001849013.1 CDS MMAR_0699 NC_010612.1 834591 834971 D hypothetical protein 834591..834971 Mycobacterium marinum M 6224948 YP_001849014.1 CDS MMAR_0700 NC_010612.1 835145 835651 D function unknown but has domain identity with acetyltransferases; hypothetical protein 835145..835651 Mycobacterium marinum M 6224949 YP_001849015.1 CDS MMAR_0701 NC_010612.1 835648 836754 D function unknown; probably involved in cellular metabolism; oxidoreductase 835648..836754 Mycobacterium marinum M 6224950 YP_001849016.1 CDS MMAR_0702 NC_010612.1 836751 837869 D monooxygenase-like hypothetical protein 836751..837869 Mycobacterium marinum M 6224951 YP_001849017.1 CDS MMAR_0703 NC_010612.1 837866 839197 D function unknown: involved in energy production and conversion; FMNH2-utilizing oxygenase 837866..839197 Mycobacterium marinum M 6224952 YP_001849018.1 CDS mmpL1 NC_010612.1 839111 841987 R function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(839111..841987) Mycobacterium marinum M 6224953 YP_001849019.1 CDS mmpS1_1 NC_010612.1 841984 842412 R membrane protein MmpS1 complement(841984..842412) Mycobacterium marinum M 6224954 YP_001849020.1 CDS fadD30 NC_010612.1 842939 844708 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 842939..844708 Mycobacterium marinum M 6224955 YP_001849021.1 CDS pks6 NC_010612.1 844705 851949 D production of unknown apolar lipid. contains two modules. KS-ATa-ACP, KS-ATa-ACP and terminal te domain; polyketide synthase 844705..851949 Mycobacterium marinum M 6224956 YP_001849022.1 CDS MMAR_0708 NC_010612.1 851973 852725 R beta lactamase-like protein complement(851973..852725) Mycobacterium marinum M 6224957 YP_001849023.1 CDS fgd1 NC_010612.1 852969 853979 D catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor; F420-dependent glucose-6-phosphate dehydrogenase Fgd1 852969..853979 Mycobacterium marinum M 6224958 YP_001849024.1 CDS pta NC_010612.1 853987 856071 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 853987..856071 Mycobacterium marinum M 6224959 YP_001849025.1 CDS ackA NC_010612.1 856061 857227 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 856061..857227 Mycobacterium marinum M 6224960 YP_001849026.1 CDS MMAR_0712 NC_010612.1 857406 858266 D hypothetical protein 857406..858266 Mycobacterium marinum M 6224961 YP_001849027.1 CDS pknG NC_010612.1 858391 860694 R involved in signal transduction (via phosphorylation). thought to regulate amino-acid uptake and stationary-phase metabolism. phosphorylates the peptide substrate myelin basic protein (MBP) at serine residues [catalytic activity: ATP + a protein = ADP + a P; serine/threonine-protein kinase PknG complement(858391..860694) Mycobacterium marinum M 6224962 YP_001849028.1 CDS glnH NC_010612.1 860694 861680 R involved in active transport of glutamine across the membrane (import). interacts with the glutamine- transport system; glutamine-binding lipoprotein GlnH complement(860694..861680) Mycobacterium marinum M 6224963 YP_001849029.1 CDS MMAR_0715 NC_010612.1 861680 862999 R hypothetical protein complement(861680..862999) Mycobacterium marinum M 6224964 YP_001849030.1 CDS mutT3 NC_010612.1 863151 863774 D possibly involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8- dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8- OXO-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to a.T to G.C transversions. mutt specifically degrades 8-OXO- dGTP to the monophosphate [catalytic activity: 8-OXO-dGTP + H2O = 8-OXO-DGMP + pyrophosphate]; mutator protein MutT3 863151..863774 Mycobacterium marinum M 6224965 YP_001849031.1 CDS thiE NC_010612.1 863746 864408 R Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase complement(863746..864408) Mycobacterium marinum M 6224966 YP_001849032.1 CDS thiO NC_010612.1 864570 865589 D involved in thiamine biosynthesis; thiamine biosynthesis oxidoreductase ThiO 864570..865589 Mycobacterium marinum M 6224967 YP_001849033.1 CDS thiS NC_010612.1 865586 865783 D part of the thiamine biosynthesis operon. ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. It is coded in the THICEFSGH operon in E. coli; thiamine biosynthesis protein ThiS 865586..865783 Mycobacterium marinum M 6224968 YP_001849034.1 CDS thiG NC_010612.1 865776 866570 D functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 865776..866570 Mycobacterium marinum M 6224969 YP_001849035.1 CDS MMAR_0721 NC_010612.1 866567 867370 D function unknown but domain identity with streptomyces scabies esterase protein; hydrolase 866567..867370 Mycobacterium marinum M 6224970 YP_001849036.1 CDS MMAR_0722 NC_010612.1 867373 867897 R hypothetical protein complement(867373..867897) Mycobacterium marinum M 6224971 YP_001849037.1 CDS MMAR_0723 NC_010612.1 868233 868352 D hypothetical protein 868233..868352 Mycobacterium marinum M 6224972 YP_001849038.1 CDS MMAR_0724 NC_010612.1 868396 868728 D hypothetical protein 868396..868728 Mycobacterium marinum M 6224973 YP_001849039.1 CDS MMAR_0725 NC_010612.1 868743 869168 D hypothetical protein 868743..869168 Mycobacterium marinum M 6224974 YP_001849040.1 CDS lpqL NC_010612.1 869301 870812 D function unknown, hydrolyzes peptides and/or proteins; lipoprotein aminopeptidase LpqL 869301..870812 Mycobacterium marinum M 6224975 YP_001849041.1 CDS lpqL_1 NC_010612.1 870809 872281 D function unknown; hydrolyzes peptides and/or proteins; lipoprotein aminopeptidase LpqL 870809..872281 Mycobacterium marinum M 6224976 YP_001849042.1 CDS lpqM NC_010612.1 872394 873887 D function unknown, possibly hydrolyzes peptides and/or proteins; lipoprotein peptidase LpqM 872394..873887 Mycobacterium marinum M 6224977 YP_001849043.1 CDS MMAR_0729 NC_010612.1 873918 877154 R function unknown, but may be involved in efflux system (probably sugar or drug transport); transmembrane transport protein complement(873918..877154) Mycobacterium marinum M 6224978 YP_001849044.1 CDS MMAR_0730 NC_010612.1 877627 879156 D function unknown but contains a N-term CheY-like response regulator receiver domain and C-term adenylyl/guanylyl cyclase catalytic domain; adenylylate/guanylate cyclase 877627..879156 Mycobacterium marinum M 6224979 YP_001849045.1 CDS MMAR_0731 NC_010612.1 879149 879514 R hypothetical protein complement(879149..879514) Mycobacterium marinum M 6224980 YP_001849046.1 CDS MMAR_0732 NC_010612.1 879511 879735 R hypothetical protein complement(879511..879735) Mycobacterium marinum M 6224981 YP_001849047.1 CDS MMAR_5559 NC_010612.1 879836 881179 D two TetR DNA-binding domains detected; putative regulatory protein 879836..881179 Mycobacterium marinum M 6224982 YP_001849048.1 CDS MMAR_0733 NC_010612.1 881088 881723 R hypothetical protein complement(881088..881723) Mycobacterium marinum M 6224983 YP_001849049.1 CDS thiD NC_010612.1 881720 882547 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(881720..882547) Mycobacterium marinum M 6224984 YP_001849050.1 CDS thiC NC_010612.1 882544 884184 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(882544..884184) Mycobacterium marinum M 6224985 YP_001849051.1 CDS MMAR_0736 NC_010612.1 884334 885104 D function unknown but may be involved in signal transduction pathway as it contains a PAS-like central senor domain and an Antar domain; putative regulatory protein 884334..885104 Mycobacterium marinum M 6224986 YP_001849052.1 CDS MMAR_0737 NC_010612.1 885208 885630 D function unknown but domain identity shared with the anti-sigma factor antagonist superfamily spoiiaa; anti sigma factor antagonist 885208..885630 Mycobacterium marinum M 6224987 YP_001849053.1 CDS MMAR_0738 NC_010612.1 885627 889490 D two-component sensor and regulator 885627..889490 Mycobacterium marinum M 6224988 YP_001849054.1 CDS MMAR_0739 NC_010612.1 889524 889802 R hypothetical protein complement(889524..889802) Mycobacterium marinum M 6224989 YP_001849055.1 CDS ctpH NC_010612.1 889849 894462 R metal cation-transporting ATPase; may catalyze the transport of undeterminaed metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminted metal cation (in) = ADP + phosphate + undeterminaed metal cation (out)]; metal cation transporting p-type ATPase CtpH complement(889849..894462) Mycobacterium marinum M 6224990 YP_001849056.1 CDS MMAR_0741 NC_010612.1 894482 894928 R transmembrane protein complement(894482..894928) Mycobacterium marinum M 6224991 YP_001849057.1 CDS xthA NC_010612.1 895072 895902 R involved in base excision repair. apurinic- apyrimidinic endonuclease. supposed to remove the damaged DNA at cytosines and guanines by cleaving at the 3' side of the ap site by a beta-elimination reaction. possibly exhibites 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'- repair diesterase and ribonuclease H activities [catalytic activity: degradation of double-stranded DNA. it acts progressively in a 3'- to 5'-direction, releasing 5'- phosphomononucleotides]; exodeoxyribonuclease III protein XthA complement(895072..895902) Mycobacterium marinum M 6224992 YP_001849058.1 CDS MMAR_0743 NC_010612.1 895905 896801 R hypothetical protein complement(895905..896801) Mycobacterium marinum M 6224993 YP_001849059.1 CDS def NC_010612.1 896801 897394 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(896801..897394) Mycobacterium marinum M 6224994 YP_001849060.1 CDS MMAR_0745 NC_010612.1 897644 897952 D hypothetical protein 897644..897952 Mycobacterium marinum M 6224995 YP_001849061.1 CDS MMAR_0746 NC_010612.1 898017 898499 D tuberculin-like protein 898017..898499 Mycobacterium marinum M 6224996 YP_001849062.1 CDS sodC NC_010612.1 898572 899288 D destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 superoxide + 2 H+ = O2 + H2O2]; periplasmic superoxide dismutase [Cu-Zn] SodC 898572..899288 Mycobacterium marinum M 6224997 YP_001849063.1 CDS MMAR_0748 NC_010612.1 899269 900420 D ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 899269..900420 Mycobacterium marinum M 6224998 YP_001849064.1 CDS MMAR_0749 NC_010612.1 900525 901196 R involved in transcriptional mechanism; GntR family transcriptional regulator complement(900525..901196) Mycobacterium marinum M 6224999 YP_001849065.1 CDS MMAR_0750 NC_010612.1 901281 902588 D function unknown, possibly involved in inorganic ion transport; MFS transporter 901281..902588 Mycobacterium marinum M 6225000 YP_001849066.1 CDS MMAR_0751 NC_010612.1 902726 903382 D hypothetical protein 902726..903382 Mycobacterium marinum M 6225001 YP_001849067.1 CDS MMAR_0752 NC_010612.1 903389 905563 R ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)]; ATPase complement(903389..905563) Mycobacterium marinum M 6225002 YP_001849068.1 CDS pssA NC_010612.1 905560 906378 R involved in phospholipid biosynthesis. generates phosphatidylserine [catalytic activity: CDP-diacylglycerol + L-serine = CMP + O-SN-phosphatidyl-L-serine]; CDP-diacylglycerol--serine O-phosphatidyltransferase complement(905560..906378) Mycobacterium marinum M 6225003 YP_001849069.1 CDS psd NC_010612.1 906432 907154 R catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase complement(906432..907154) Mycobacterium marinum M 6225004 YP_001849070.1 CDS MMAR_0755 NC_010612.1 907240 910416 R PE-PGRS family protein complement(907240..910416) Mycobacterium marinum M 6225005 YP_001849071.1 CDS moeA2 NC_010612.1 910730 911935 R involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes (by similarity); molybdopterin biosynthesis protein MoeA2 complement(910730..911935) Mycobacterium marinum M 6225006 YP_001849072.1 CDS MMAR_0757 NC_010612.1 911954 912892 R function unknown, possibly involved in cellular metabolism; short chain dehydrogenase complement(911954..912892) Mycobacterium marinum M 6225007 YP_001849073.1 CDS MMAR_0758 NC_010612.1 912939 913442 R hypothetical protein complement(912939..913442) Mycobacterium marinum M 6225008 YP_001849074.1 CDS groEL NC_010612.1 913752 915377 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 913752..915377 Mycobacterium marinum M 6225009 YP_001849075.1 CDS MMAR_0760 NC_010612.1 915462 915851 R hypothetical protein complement(915462..915851) Mycobacterium marinum M 6225010 YP_001849076.1 CDS MMAR_0761 NC_010612.1 915918 917384 R PPE family protein complement(915918..917384) Mycobacterium marinum M 6225011 YP_001849077.1 CDS MMAR_0762 NC_010612.1 917480 919228 R hydrolizes a specific D-amino acid; D-amino acid aminohydrolase complement(917480..919228) Mycobacterium marinum M 6225012 YP_001849078.1 CDS MMAR_0763 NC_010612.1 919294 919809 D hypothetical protein 919294..919809 Mycobacterium marinum M 6225013 YP_001849079.1 CDS MMAR_0764 NC_010612.1 919819 920667 D hypothetical protein 919819..920667 Mycobacterium marinum M 6225014 YP_001849080.1 CDS MMAR_0765 NC_010612.1 920679 921377 R hypothetical protein complement(920679..921377) Mycobacterium marinum M 6225015 YP_001849081.1 CDS sigK NC_010612.1 921374 921937 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK complement(921374..921937) Mycobacterium marinum M 6225016 YP_001849082.1 CDS MMAR_0767 NC_010612.1 921983 922777 R transmembrane protein complement(921983..922777) Mycobacterium marinum M 6225017 YP_001849083.1 CDS ufaA1 NC_010612.1 922774 924060 R transfers a methylene group from S-adenosyl-L- methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge [catalytic activity: S-adenosyl-L- methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid]; cyclopropane-fatty-acyl-phospholipid synthase complement(922774..924060) Mycobacterium marinum M 6225018 YP_001849084.1 CDS MMAR_0769 NC_010612.1 924057 924773 R hypothetical protein complement(924057..924773) Mycobacterium marinum M 6225019 YP_001849085.1 CDS MMAR_0770 NC_010612.1 924767 926083 R oxidoreductase complement(924767..926083) Mycobacterium marinum M 6225020 YP_001849086.1 CDS mmpL5_2 NC_010612.1 926142 929039 R thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(926142..929039) Mycobacterium marinum M 6225021 YP_001849087.1 CDS mmpS4_2 NC_010612.1 929036 929455 R membrane protein MmpS4_2 complement(929036..929455) Mycobacterium marinum M 6225022 YP_001849088.1 CDS MMAR_0773 NC_010612.1 929771 930508 D putative regulatory protein 929771..930508 Mycobacterium marinum M 6225023 YP_001849089.1 CDS MMAR_0774 NC_010612.1 930767 931213 D hypothetical protein 930767..931213 Mycobacterium marinum M 6225024 YP_001849090.1 CDS MMAR_0775 NC_010612.1 931210 934236 D the function of MmpL proteins is not known, although it has been suggested that they may be involved in lipid transport; MmpL family transport protein 931210..934236 Mycobacterium marinum M 6225025 YP_001849091.1 CDS MMAR_0776 NC_010612.1 934268 934615 R hypothetical protein complement(934268..934615) Mycobacterium marinum M 6225026 YP_001849092.1 CDS MMAR_0777 NC_010612.1 934891 935340 R hypothetical protein complement(934891..935340) Mycobacterium marinum M 6225027 YP_001849093.1 CDS echA2 NC_010612.1 935407 936321 R catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(935407..936321) Mycobacterium marinum M 6225028 YP_001849094.1 CDS MMAR_0779 NC_010612.1 936413 938509 R function unknown; hydrolyzes peptides and/or proteins; peptidase complement(936413..938509) Mycobacterium marinum M 6225029 YP_001849095.1 CDS putA_1 NC_010612.1 938575 940098 D interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase, PutA 938575..940098 Mycobacterium marinum M 6225030 YP_001849096.1 CDS MMAR_0781 NC_010612.1 940098 940598 D hypothetical protein 940098..940598 Mycobacterium marinum M 6225031 YP_001849097.1 CDS MMAR_0782 NC_010612.1 940619 940897 D hypothetical protein 940619..940897 Mycobacterium marinum M 6225032 YP_001849098.1 CDS MMAR_0783 NC_010612.1 940890 941498 D transmembrane protein 940890..941498 Mycobacterium marinum M 6225033 YP_001849099.1 CDS bioF2_4 NC_010612.1 941556 942944 R could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase complement(941556..942944) Mycobacterium marinum M 6225034 YP_001849100.1 CDS lpd NC_010612.1 943178 944581 D E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 943178..944581 Mycobacterium marinum M 6225035 YP_001849101.1 CDS MMAR_0786 NC_010612.1 944584 944859 D hypothetical protein 944584..944859 Mycobacterium marinum M 6225036 YP_001849102.1 CDS MMAR_5564 NC_010612.1 944865 945059 R hypothetical protein complement(944865..945059) Mycobacterium marinum M 6225037 YP_001849103.1 CDS MMAR_0787 NC_010612.1 945132 946370 R PPE family protein complement(945132..946370) Mycobacterium marinum M 6225038 YP_001849104.1 CDS MMAR_0789 NC_010612.1 946601 947167 R hypothetical protein complement(946601..947167) Mycobacterium marinum M 6225039 YP_001849105.1 CDS MMAR_0790 NC_010612.1 947164 948588 R possibly involved in transcriptional mechanism; transcriptional regulatory protein complement(947164..948588) Mycobacterium marinum M 6225040 YP_001849106.1 CDS MMAR_0791 NC_010612.1 948763 949557 D hypothetical protein 948763..949557 Mycobacterium marinum M 6225041 YP_001849107.1 CDS icl NC_010612.1 949865 951151 D involved in glyoxylate bypass (at the first step), an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi) [catalytic activity: isocitrate = succinate + glyoxylate]. involved in the persistence in the host; isocitrate lyase Icl 949865..951151 Mycobacterium marinum M 6225042 YP_001849108.1 CDS fadB2 NC_010612.1 951315 952181 D converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 951315..952181 Mycobacterium marinum M 6225043 YP_001849109.1 CDS umaA NC_010612.1 952317 953177 D involved in mycolic acid modification or synthesis; mycolic acid synthase UmaA 952317..953177 Mycobacterium marinum M 6225044 YP_001849110.1 CDS MMAR_0795 NC_010612.1 953410 954381 R transposition of ISMyma04; transposase for ISMyma04 complement(953410..954381) Mycobacterium marinum M 6225045 YP_001849111.1 CDS pcaA NC_010612.1 954500 955363 R involved in the mycolic acid modification or synthesis; essential for the cyclopropanation function. required for cording and mycolic acid cyclopropane ring synthesis in the cell wall; mycolic acid synthase PcaA complement(954500..955363) Mycobacterium marinum M 6225046 YP_001849112.1 CDS MMAR_0797 NC_010612.1 955521 956225 R possibly involved in transcriptional mechanism; TetR family transcriptional regulator complement(955521..956225) Mycobacterium marinum M 6225047 YP_001849113.1 CDS MMAR_0798 NC_010612.1 956417 957700 D transmembrane protein 956417..957700 Mycobacterium marinum M 6225048 YP_001849114.1 CDS MMAR_0799 NC_010612.1 957786 958202 D possibly involved in transcriptional mechanism; transcriptional regulatory protein 957786..958202 Mycobacterium marinum M 6225049 YP_001849115.1 CDS hbhA NC_010612.1 958557 959162 D required for extrapulmonary dissemination. mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells; binds heparin, dextran sulfate, fucoidan and chondroitin sulfate. promotes hemagglutination of erythrocytes of certain host species. induces mycobacterial aggregation; iron-regulated heparin binding hemagglutinin HbhA 958557..959162 Mycobacterium marinum M 6225050 YP_001849116.1 CDS MMAR_0801 NC_010612.1 959315 959602 D transmembrane protein 959315..959602 Mycobacterium marinum M 6225051 YP_001849117.1 CDS MMAR_0802 NC_010612.1 959607 960089 D hypothetical protein 959607..960089 Mycobacterium marinum M 6225052 YP_001849118.1 CDS deoC NC_010612.1 960089 960769 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 960089..960769 Mycobacterium marinum M 6225053 YP_001849119.1 CDS MMAR_0804 NC_010612.1 960788 961834 R hypothetical protein complement(960788..961834) Mycobacterium marinum M 6225054 YP_001849120.1 CDS MMAR_0805 NC_010612.1 961831 962673 R function unknown, hydrolytic enzyme probably involved in cellular metabolism; amidohydrolase complement(961831..962673) Mycobacterium marinum M 6225055 YP_001849121.1 CDS MMAR_0806 NC_010612.1 962704 969012 R PE-PGRS family protein complement(962704..969012) Mycobacterium marinum M 6225056 YP_001849122.1 CDS MMAR_0807 NC_010612.1 969429 969953 R hypothetical protein complement(969429..969953) Mycobacterium marinum M 6225057 YP_001849123.1 CDS murB NC_010612.1 969980 971080 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 969980..971080 Mycobacterium marinum M 6225058 YP_001849124.1 CDS lprQ NC_010612.1 971116 972504 D lipoprotein LprQ 971116..972504 Mycobacterium marinum M 6225059 YP_001849125.1 CDS MMAR_0810 NC_010612.1 972488 973240 R function unknown, possibly involved in cellular metabolism; short-chain type oxidoreductase complement(972488..973240) Mycobacterium marinum M 6225060 YP_001849126.1 CDS MMAR_0811 NC_010612.1 973483 974718 D possibly involved in transcriptional mechanism; transcriptional regulatory protein 973483..974718 Mycobacterium marinum M 6225061 YP_001849127.1 CDS MMAR_0812 NC_010612.1 974730 976130 D thought to be involved in polyprenolmannose synthesis; mannosyltransferase 974730..976130 Mycobacterium marinum M 6225062 YP_001849128.1 CDS MMAR_0813 NC_010612.1 976127 976678 D hypothetical protein 976127..976678 Mycobacterium marinum M 6225063 YP_001849129.1 CDS gpmA NC_010612.1 976692 977447 D 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 976692..977447 Mycobacterium marinum M 6225064 YP_001849130.1 CDS senX3 NC_010612.1 977583 978809 D sensor part of a two-component regulatory system. probably forms part of a two-component regulatory system SenX3/RegX3; phosphorylates RegX3; two-component sensor histidine kinase SenX3 977583..978809 Mycobacterium marinum M 6225065 YP_001849131.1 CDS regX3 NC_010612.1 978965 979648 D transcriptional regulatory protein part of the two-component regulatory system RegX3/SenX3; two-component sensory transduction protein RegX3 978965..979648 Mycobacterium marinum M 6225066 YP_001849132.1 CDS MMAR_0817 NC_010612.1 979611 981524 R function unknown, probably involved in cellular metabolism; oxidoreductase GMC-type complement(979611..981524) Mycobacterium marinum M 6225067 YP_001849133.1 CDS MMAR_0818 NC_010612.1 981521 981862 R hypothetical protein complement(981521..981862) Mycobacterium marinum M 6225068 YP_001849134.1 CDS MMAR_0819 NC_010612.1 981895 982866 R hypothetical protein complement(981895..982866) Mycobacterium marinum M 6225069 YP_001849135.1 CDS MMAR_0820 NC_010612.1 982954 983691 D involved in transcriptional mechanism; GntR family transcriptional regulator 982954..983691 Mycobacterium marinum M 6225070 YP_001849136.1 CDS MMAR_0821 NC_010612.1 983704 984498 R hypothetical protein complement(983704..984498) Mycobacterium marinum M 6225071 YP_001849137.1 CDS MMAR_0822 NC_010612.1 984638 985672 D hypothetical protein 984638..985672 Mycobacterium marinum M 6225072 YP_001849138.1 CDS MMAR_0823 NC_010612.1 985669 986733 D transmembrane protein 985669..986733 Mycobacterium marinum M 6225073 YP_001849139.1 CDS MMAR_0824 NC_010612.1 986750 987592 D hypothetical protein 986750..987592 Mycobacterium marinum M 6225074 YP_001849140.1 CDS MMAR_0825 NC_010612.1 987594 988439 D hypothetical protein 987594..988439 Mycobacterium marinum M 6225075 YP_001849141.1 CDS proC NC_010612.1 988464 989348 D catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 988464..989348 Mycobacterium marinum M 6225076 YP_001849142.1 CDS MMAR_0827 NC_010612.1 989490 989747 D hypothetical protein 989490..989747 Mycobacterium marinum M 6225077 YP_001849143.1 CDS MMAR_0828 NC_010612.1 989886 989987 D hypothetical protein 989886..989987 Mycobacterium marinum M 6225078 YP_001849144.1 CDS galE2 NC_010612.1 990066 991199 D involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase GalE2 990066..991199 Mycobacterium marinum M 6225079 YP_001849145.1 CDS MMAR_0830 NC_010612.1 991205 992272 D hypothetical protein 991205..992272 Mycobacterium marinum M 6225080 YP_001849146.1 CDS cmaA2 NC_010612.1 992326 993237 R essential for the cyclopropanation function. transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge. mycolic acids, which represent the major constituent of mycobacterial cell wall complex, act as substrates [catalytic activity: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L- homocysteine + phospholipid cyclopropane fatty acid]; cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 complement(992326..993237) Mycobacterium marinum M 6225081 YP_001849147.1 CDS MMAR_0832 NC_010612.1 993260 993760 R hypothetical protein complement(993260..993760) Mycobacterium marinum M 6225082 YP_001849148.1 CDS serB1 NC_010612.1 993805 994716 R removes a phosphate from phosphoserine [catalytic activity: phosphoserine + H2O = serine + phosphate]; phosphoserine phosphatase SerB1 complement(993805..994716) Mycobacterium marinum M 6225083 YP_001849149.1 CDS coxS_1 NC_010612.1 994905 995507 D involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase small chain CoxS 994905..995507 Mycobacterium marinum M 6225084 YP_001849150.1 CDS coxM_1 NC_010612.1 995511 996488 D function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase medium chain CoxM 995511..996488 Mycobacterium marinum M 6225085 YP_001849151.1 CDS coxL_1 NC_010612.1 996485 998662 D involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase large chain CoxL 996485..998662 Mycobacterium marinum M 6225086 YP_001849152.1 CDS MMAR_0837 NC_010612.1 998702 1000447 R PE-PGRS family protein complement(998702..1000447) Mycobacterium marinum M 6225087 YP_001849153.1 CDS MMAR_0838 NC_010612.1 1000885 1001679 R hypothetical protein complement(1000885..1001679) Mycobacterium marinum M 6225088 YP_001849154.1 CDS mimJ NC_010612.1 1001852 1002403 R Transposon insertion in this sequence results in intracellular replication deficiency; macrophage infection protein, MimJ complement(1001852..1002403) Mycobacterium marinum M 6225089 YP_001849155.1 CDS MMAR_0839 NC_010612.1 1002351 1002788 D MmpS-family membrane protein 1002351..1002788 Mycobacterium marinum M 6225090 YP_001849156.1 CDS mmpL2 NC_010612.1 1002785 1005778 D thought to be involved in fatty acid transport; transmembrane transport protein MmpL 1002785..1005778 Mycobacterium marinum M 6225091 YP_001849157.1 CDS MMAR_0841 NC_010612.1 1005778 1006053 D hypothetical protein 1005778..1006053 Mycobacterium marinum M 6225092 YP_001849158.1 CDS hemA NC_010612.1 1006164 1007585 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1006164..1007585 Mycobacterium marinum M 6225093 YP_001849159.1 CDS hemC NC_010612.1 1007599 1008543 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 1007599..1008543 Mycobacterium marinum M 6225094 YP_001849160.1 CDS hemD NC_010612.1 1008565 1010241 D possibly involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L- methionine + uroporphyrin III = 2 S-adenosyl-L- homocysteine + sirohydrochlorin]; uroporphyrin-III C-methyltransferase HemD 1008565..1010241 Mycobacterium marinum M 6225095 YP_001849161.1 CDS hemB NC_010612.1 1010281 1011264 D catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 1010281..1011264 Mycobacterium marinum M 6225096 YP_001849162.1 CDS MMAR_0846 NC_010612.1 1011276 1011812 D transmembrane protein 1011276..1011812 Mycobacterium marinum M 6225097 YP_001849163.1 CDS MMAR_0847 NC_010612.1 1011809 1012093 D transmembrane protein 1011809..1012093 Mycobacterium marinum M 6225098 YP_001849164.1 CDS MMAR_0851 NC_010612.1 1012526 1038805 R function unknown. contains 8 predicted modules, each with a minimum domain complement (C, a & T domains), responsible for the synthesis of an 8 amino acid metabolite. predicted sequential condensation of the following amino acids: F, R or F, F, T, F, F or C, L, F and followed by an integral thioesterase domain; non-ribosomal peptide synthetase complement(1012526..1038805) Mycobacterium marinum M 6225100 YP_001849165.1 CDS cyp185A4 NC_010612.1 1040059 1041483 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. some have been shown to bind tightly to a range of azole-based antifungal drugs (E.G. miconazole, clotrimazole); cytochrome P450 185A4 Cyp185A4 complement(1040059..1041483) Mycobacterium marinum M 6225101 YP_001849166.1 CDS MMAR_0853 NC_010612.1 1042445 1042894 R hypothetical protein complement(1042445..1042894) Mycobacterium marinum M 6225102 YP_001849167.1 CDS MMAR_0854 NC_010612.1 1043117 1044436 D membrane acyltransferase 1043117..1044436 Mycobacterium marinum M 6225103 YP_001849168.1 CDS MMAR_0855 NC_010612.1 1044542 1045273 D function unknown, domain identity to secreted hydrolases of the SgnH_hydrolase subfamily; hypothetical protein 1044542..1045273 Mycobacterium marinum M 6225104 YP_001849169.1 CDS MMAR_0856 NC_010612.1 1045343 1045459 R hypothetical protein complement(1045343..1045459) Mycobacterium marinum M 6225105 YP_001849170.1 CDS MMAR_0857 NC_010612.1 1045571 1047733 R transmembrane acyltransferase complement(1045571..1047733) Mycobacterium marinum M 6225106 YP_001849171.1 CDS MMAR_0858 NC_010612.1 1047785 1048729 R has homology to a putative esterase domain; hypothetical protein complement(1047785..1048729) Mycobacterium marinum M 6225107 YP_001849172.1 CDS MMAR_0859 NC_010612.1 1048882 1049745 D the universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general 'stress endurance' activity; universal stress protein UspA 1048882..1049745 Mycobacterium marinum M 6225108 YP_001849173.1 CDS ctpF NC_010612.1 1049868 1052585 D metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation(out); metal cation-transporting p-type ATPase F, CtpF 1049868..1052585 Mycobacterium marinum M 6225109 YP_001849174.1 CDS MMAR_0861 NC_010612.1 1052856 1054544 D contains a UbiE domain: methylase involved in ubiquinone/menaquinone biosynthesis; glycine-sarcosine methyltransferase 1052856..1054544 Mycobacterium marinum M 6225110 YP_001849175.1 CDS gabP NC_010612.1 1054714 1056039 D involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane; gamma-aminobutyrate permease GabP 1054714..1056039 Mycobacterium marinum M 6225111 YP_001849176.1 CDS apbA NC_010612.1 1056046 1056978 R ketopantoate reductase PanE/ApbA. this is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases. the reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and pane are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway; ketopantoate reductase, ApbA complement(1056046..1056978) Mycobacterium marinum M 6225112 YP_001849177.1 CDS MMAR_0864 NC_010612.1 1056994 1058151 R mandelate racemase complement(1056994..1058151) Mycobacterium marinum M 6225113 YP_001849178.1 CDS MMAR_0866 NC_010612.1 1058364 1058711 D hypothetical protein 1058364..1058711 Mycobacterium marinum M 6225114 YP_001849179.1 CDS MMAR_0867 NC_010612.1 1058708 1059007 R contains glutaredoxin domain; hypothetical protein complement(1058708..1059007) Mycobacterium marinum M 6225115 YP_001849180.1 CDS MMAR_0868 NC_010612.1 1059110 1060453 R hypothetical protein complement(1059110..1060453) Mycobacterium marinum M 6225116 YP_001849181.1 CDS MMAR_0869 NC_010612.1 1060625 1061962 D amino acid permease 1060625..1061962 Mycobacterium marinum M 6225117 YP_001849182.1 CDS hemL NC_010612.1 1062036 1063367 D Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1062036..1063367 Mycobacterium marinum M 6225118 YP_001849183.1 CDS MMAR_0871 NC_010612.1 1063367 1063975 D contains fructose-2,6-bisphosphatase domain [carbohydrate transport and metabolism]; hypothetical protein 1063367..1063975 Mycobacterium marinum M 6225119 YP_001849184.1 CDS MMAR_0872 NC_010612.1 1063978 1064589 D thioredoxin protein 1063978..1064589 Mycobacterium marinum M 6225120 YP_001849185.1 CDS ccsA NC_010612.1 1064586 1065377 D required during cytochrome biogenesis at the step of HemE attachment; cytochrome C-type biogenesis protein, CcsA 1064586..1065377 Mycobacterium marinum M 6225121 YP_001849186.1 CDS MMAR_0874 NC_010612.1 1065479 1067053 D required for cytochrome C biosynthesis; ResB-family protein 1065479..1067053 Mycobacterium marinum M 6225122 YP_001849187.1 CDS ccsB NC_010612.1 1067050 1068036 D required during cytochrome biogenesis at the step of HemE attachment; cytochrome C-type biogenesis protein, CcsB 1067050..1068036 Mycobacterium marinum M 6225123 YP_001849188.1 CDS MMAR_0876 NC_010612.1 1068078 1069394 D hypothetical protein 1068078..1069394 Mycobacterium marinum M 6225124 YP_001849189.1 CDS MMAR_0877 NC_010612.1 1069400 1069552 R hypothetical protein complement(1069400..1069552) Mycobacterium marinum M 6225125 YP_001849190.1 CDS MMAR_0878 NC_010612.1 1069647 1069967 D hypothetical protein 1069647..1069967 Mycobacterium marinum M 6225126 YP_001849191.1 CDS fabH NC_010612.1 1069975 1070982 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(1069975..1070982) Mycobacterium marinum M 6225127 YP_001849192.1 CDS menA NC_010612.1 1071081 1071956 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(1071081..1071956) Mycobacterium marinum M 6225128 YP_001849193.1 CDS pnp NC_010612.1 1071997 1072791 D Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 1071997..1072791 Mycobacterium marinum M 6225129 YP_001849194.1 CDS galE3 NC_010612.1 1072788 1073828 D involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase 1072788..1073828 Mycobacterium marinum M 6225130 YP_001849195.1 CDS MMAR_0883 NC_010612.1 1073836 1075503 R hypothetical protein complement(1073836..1075503) Mycobacterium marinum M 6225131 YP_001849196.1 CDS MMAR_0884 NC_010612.1 1075815 1077746 D hypothetical protein 1075815..1077746 Mycobacterium marinum M 6225132 YP_001849197.1 CDS MMAR_0885 NC_010612.1 1077776 1078432 D substrate (sugar) unknown [catalytic activity: NDP- sugar + dolichyl phosphate = NDP + dolichyl sugar phosphate]; glycosyl transferase - dolichol-P-sugar synthase 1077776..1078432 Mycobacterium marinum M 6225133 YP_001849198.1 CDS MMAR_0886 NC_010612.1 1078429 1079091 D hypothetical protein 1078429..1079091 Mycobacterium marinum M 6225134 YP_001849199.1 CDS MMAR_0887 NC_010612.1 1079123 1080475 R hypothetical protein complement(1079123..1080475) Mycobacterium marinum M 6225135 YP_001849200.1 CDS menE NC_010612.1 1080487 1081596 R involved in menaquinone biosynthesis. O- succinylbenzoic acid (OSB) to O-succinylbenzoyl-CoA (OSB- CoA) [catalytic activity: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA]; O-succinylbenzoic acid--CoA ligase complement(1080487..1081596) Mycobacterium marinum M 6225136 YP_001849201.1 CDS MMAR_0889 NC_010612.1 1081641 1081937 R hypothetical protein complement(1081641..1081937) Mycobacterium marinum M 6225137 YP_001849202.1 CDS MMAR_0890 NC_010612.1 1081998 1082282 R hypothetical protein complement(1081998..1082282) Mycobacterium marinum M 6225138 YP_001849203.1 CDS pitA NC_010612.1 1082279 1083556 R involved in low-affinity inorganic phosphate transport across the membrane. responsible for the translocation of the substrate across the membrane; low-affinity inorganic phosphate transporter, PitA complement(1082279..1083556) Mycobacterium marinum M 6225139 YP_001849204.1 CDS MMAR_0892 NC_010612.1 1083654 1084061 R glyoxalase complement(1083654..1084061) Mycobacterium marinum M 6225140 YP_001849205.1 CDS MMAR_0893 NC_010612.1 1084075 1084704 R hypothetical protein complement(1084075..1084704) Mycobacterium marinum M 6225141 YP_001849206.1 CDS MMAR_0894 NC_010612.1 1084723 1085610 R short chain dehydrogenase complement(1084723..1085610) Mycobacterium marinum M 6225142 YP_001849207.1 CDS menB NC_010612.1 1085654 1086556 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(1085654..1086556) Mycobacterium marinum M 6225143 YP_001849208.1 CDS MMAR_0896 NC_010612.1 1086553 1087254 R hypothetical protein complement(1086553..1087254) Mycobacterium marinum M 6225144 YP_001849209.1 CDS fadD8 NC_010612.1 1087364 1088965 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1087364..1088965) Mycobacterium marinum M 6225145 YP_001849210.1 CDS MMAR_0898 NC_010612.1 1089054 1090658 D has significant domain identity to predicted metal- dependent hydrolases; hypothetical protein 1089054..1090658 Mycobacterium marinum M 6225146 YP_001849211.1 CDS menC NC_010612.1 1090655 1091638 D catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 1090655..1091638 Mycobacterium marinum M 6225147 YP_001849212.1 CDS bpoC NC_010612.1 1091631 1092419 D non-haem peroxidase; bromoperoxidase BpoC 1091631..1092419 Mycobacterium marinum M 6225148 YP_001849213.1 CDS menD NC_010612.1 1092483 1094129 D SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 1092483..1094129 Mycobacterium marinum M 6225149 YP_001849214.1 CDS MMAR_0902 NC_010612.1 1094126 1094650 D hypothetical protein 1094126..1094650 Mycobacterium marinum M 6225150 YP_001849215.1 CDS pimB NC_010612.1 1094726 1095877 D involved in lipoarabinomannan (lam) biosynthesis; mannosyltransferase, PimB 1094726..1095877 Mycobacterium marinum M 6225151 YP_001849216.1 CDS MMAR_0904 NC_010612.1 1095874 1096476 R mar family; transcriptional regulator complement(1095874..1096476) Mycobacterium marinum M 6225152 YP_001849217.1 CDS MMAR_0905 NC_010612.1 1096505 1097680 D hypothetical protein 1096505..1097680 Mycobacterium marinum M 6225153 YP_001849218.1 CDS MMAR_0906 NC_010612.1 1097670 1098977 D hypothetical protein 1097670..1098977 Mycobacterium marinum M 6225154 YP_001849219.1 CDS ubiE NC_010612.1 1099006 1099701 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 1099006..1099701 Mycobacterium marinum M 6225155 YP_001849220.1 CDS MMAR_0908 NC_010612.1 1099720 1100055 R hypothetical protein complement(1099720..1100055) Mycobacterium marinum M 6225156 YP_001849221.1 CDS MMAR_0909 NC_010612.1 1100088 1100777 R methyltransferase complement(1100088..1100777) Mycobacterium marinum M 6225157 YP_001849222.1 CDS MMAR_0910 NC_010612.1 1100831 1102069 R has significant domain conservation with dehydrogenases (flavoproteins) [energy production and conversion]; FAD-linked oxidoreductase complement(1100831..1102069) Mycobacterium marinum M 6225158 YP_001849223.1 CDS grcC1 NC_010612.1 1102091 1103098 D supplies polyprenyl diphosphate; polyprenyl diphosphate synthetase, GrcC1 1102091..1103098 Mycobacterium marinum M 6225159 YP_001849224.1 CDS hspX NC_010612.1 1103189 1104049 D putative metalloprotease; heat shock protein HtpX 1103189..1104049 Mycobacterium marinum M 6225160 YP_001849225.1 CDS sulP NC_010612.1 1104070 1105671 R generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane; transmembrane carbonic anhydrase, SulP complement(1104070..1105671) Mycobacterium marinum M 6225161 YP_001849226.1 CDS sulP_1 NC_010612.1 1105964 1107517 R transmembrane carbonic anhydrase, SulP complement(1105964..1107517) Mycobacterium marinum M 6225162 YP_001849227.1 CDS gpdA1 NC_010612.1 1107750 1108775 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(1107750..1108775) Mycobacterium marinum M 6225163 YP_001849228.1 CDS MMAR_0916 NC_010612.1 1108935 1110431 D hydrolyzes peptides and/or proteins. cleaves preferentially after serine residues; trypsin-like serine protease 1108935..1110431 Mycobacterium marinum M 6225164 YP_001849229.1 CDS MMAR_0917 NC_010612.1 1110460 1111968 R function unknown but domain identity suggests this CDS encodes a flavoprotein involved in K+ transport; flavin-binding monooxygenase complement(1110460..1111968) Mycobacterium marinum M 6225165 YP_001849230.1 CDS MMAR_0918 NC_010612.1 1112418 1115708 R function unknown; the lantibiotics are a group of ribosomally synthesised, post-translationally modified peptides containing unusual amino acids, such as dehydrated and lanthionine residuesthe lantibiotics are a group of ribosomally synthesised, post-translationally modified peptides containing unusual amino acids, such as dehydrated and lanthionine residues; lantibiotic modifying enzyme complement(1112418..1115708) Mycobacterium marinum M 6225166 YP_001849231.1 CDS rimL NC_010612.1 1115857 1116393 R domain identity to N-acetylases of ribosomal proteins; acetyltransferase, RimL complement(1115857..1116393) Mycobacterium marinum M 6225167 YP_001849232.1 CDS MMAR_0920 NC_010612.1 1116495 1116986 R putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein complement(1116495..1116986) Mycobacterium marinum M 6225168 YP_001849233.1 CDS MMAR_0921 NC_010612.1 1117179 1119563 R ABC-type transport system, involved in lipoprotein release, permease component; ABC transporter complement(1117179..1119563) Mycobacterium marinum M 6225170 YP_001849234.1 CDS MMAR_0922 NC_010612.1 1119560 1120294 R ABC transporter ATP-binding protein complement(1119560..1120294) Mycobacterium marinum M 6225171 YP_001849235.1 CDS MMAR_0923 NC_010612.1 1120291 1120896 R involved in transcriptional mechanism; transcriptional regulator complement(1120291..1120896) Mycobacterium marinum M 6225172 YP_001849236.1 CDS MMAR_0924 NC_010612.1 1121019 1121831 R carveol-like dehydrogenase complement(1121019..1121831) Mycobacterium marinum M 6225173 YP_001849237.1 CDS nhaP NC_010612.1 1121953 1123173 R NhaP-type Na+/H+ and K+/H+ antiporter: inorganic ion transport and metabolism]. antiporters are ubiquitous membrane proteins that are involved in homeostasis of H(+) and na(+) throughout the biological kingdom; ion antiporter, NhaP complement(1121953..1123173) Mycobacterium marinum M 6225174 YP_001849238.1 CDS MMAR_0926 NC_010612.1 1123331 1125532 R PPE family protein complement(1123331..1125532) Mycobacterium marinum M 6225175 YP_001849239.1 CDS MMAR_0927 NC_010612.1 1125902 1126099 D hypothetical protein 1125902..1126099 Mycobacterium marinum M 6225176 YP_001849240.1 CDS cyp189A6 NC_010612.1 1126116 1127336 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 189A6 Cyp189A6 complement(1126116..1127336) Mycobacterium marinum M 6225177 YP_001849241.1 CDS MMAR_0929 NC_010612.1 1127453 1128076 D involved in transcriptional mechanism; TetR family transcriptional regulator 1127453..1128076 Mycobacterium marinum M 6225178 YP_001849242.1 CDS embR_2 NC_010612.1 1128147 1128977 R involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB; transcriptional regulatory protein EmbR_2 complement(1128147..1128977) Mycobacterium marinum M 6225179 YP_001849243.1 CDS MMAR_0931 NC_010612.1 1129286 1130005 D hypothetical protein 1129286..1130005 Mycobacterium marinum M 6225180 YP_001849244.1 CDS MMAR_0932 NC_010612.1 1130299 1133964 D PPE family protein 1130299..1133964 Mycobacterium marinum M 6225181 YP_001849245.1 CDS MMAR_0933 NC_010612.1 1133992 1134357 D hypothetical protein 1133992..1134357 Mycobacterium marinum M 6225182 YP_001849246.1 CDS MMAR_0934 NC_010612.1 1134462 1135484 D methyltransferase/methylase 1134462..1135484 Mycobacterium marinum M 6225183 YP_001849247.1 CDS MMAR_0935 NC_010612.1 1135532 1136356 D adenylate cyclase 1135532..1136356 Mycobacterium marinum M 6225184 YP_001849248.1 CDS atsA_1 NC_010612.1 1136481 1138823 D arylsulfatase AtsA 1136481..1138823 Mycobacterium marinum M 6225185 YP_001849249.1 CDS gatA_1 NC_010612.1 1138893 1140395 D component of the translational apparatus. furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. the reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-glu-tRNA(Gln) [catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L- glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L- glutamate]; peptide amidase, GatA 1138893..1140395 Mycobacterium marinum M 6225186 YP_001849250.1 CDS cyp135B4 NC_010612.1 1140594 1141985 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 135B4 Cyp135B4 1140594..1141985 Mycobacterium marinum M 6225187 YP_001849251.1 CDS MMAR_0939 NC_010612.1 1141970 1143139 R hypothetical protein complement(1141970..1143139) Mycobacterium marinum M 6225188 YP_001849252.1 CDS galT NC_010612.1 1143252 1144328 D involved in galactose metabolism (Leloir pathway) [catalytic activity: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose]; galactose-1-phosphate uridylyltransferase 1143252..1144328 Mycobacterium marinum M 6225189 YP_001849253.1 CDS galK NC_010612.1 1144325 1145425 D catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1144325..1145425 Mycobacterium marinum M 6225190 YP_001849254.1 CDS MMAR_0942 NC_010612.1 1145506 1146528 D ArsR family; transcriptional regulator 1145506..1146528 Mycobacterium marinum M 6225191 YP_001849255.1 CDS MMAR_0943 NC_010612.1 1146525 1150802 R PE-PGRS family protein complement(1146525..1150802) Mycobacterium marinum M 6225192 YP_001849256.1 CDS MMAR_0944 NC_010612.1 1151102 1151905 D hypothetical protein 1151102..1151905 Mycobacterium marinum M 6225193 YP_001849257.1 CDS MMAR_0945 NC_010612.1 1151948 1154224 R hypothetical protein complement(1151948..1154224) Mycobacterium marinum M 6225194 YP_001849258.1 CDS MMAR_0946 NC_010612.1 1154343 1155116 D hypothetical protein 1154343..1155116 Mycobacterium marinum M 6225195 YP_001849259.1 CDS MMAR_0947 NC_010612.1 1155091 1156611 R contains hydrolase domain; hypothetical protein complement(1155091..1156611) Mycobacterium marinum M 6225196 YP_001849260.1 CDS MMAR_0948 NC_010612.1 1156673 1157158 R hypothetical protein complement(1156673..1157158) Mycobacterium marinum M 6225197 YP_001849261.1 CDS lppF NC_010612.1 1157272 1158567 R lipoprotein LppF complement(1157272..1158567) Mycobacterium marinum M 6225198 YP_001849262.1 CDS lpqN NC_010612.1 1158771 1159457 R lipoprotein LpqN complement(1158771..1159457) Mycobacterium marinum M 6225199 YP_001849263.1 CDS MMAR_0951 NC_010612.1 1159548 1159697 D hypothetical protein 1159548..1159697 Mycobacterium marinum M 6225200 YP_001849264.1 CDS MMAR_0952 NC_010612.1 1159708 1162347 D function unknown role incarbohydrate transport and metabolism; alpha-1,2-mannosidase 1159708..1162347 Mycobacterium marinum M 6225201 YP_001849265.1 CDS MMAR_0953 NC_010612.1 1162370 1164745 R integral membrane protein complement(1162370..1164745) Mycobacterium marinum M 6225202 YP_001849266.1 CDS MMAR_0954 NC_010612.1 1165242 1166504 R function unknown, imidazolonepropionase is an amidohydrolase; imidazolonepropionase complement(1165242..1166504) Mycobacterium marinum M 6225204 YP_001849267.1 CDS MMAR_0955 NC_010612.1 1166636 1167577 D hypothetical protein 1166636..1167577 Mycobacterium marinum M 6225205 YP_001849268.1 CDS recD NC_010612.1 1167598 1169361 R involved in homologous recombination; exodeoxyribonuclease V (alpha chain), RecD complement(1167598..1169361) Mycobacterium marinum M 6225206 YP_001849269.1 CDS recB NC_010612.1 1169358 1172690 R involved in homologous recombination; exodeoxyribonuclease V (beta chain), RecB complement(1169358..1172690) Mycobacterium marinum M 6225207 YP_001849270.1 CDS recC NC_010612.1 1172690 1175989 R involved in homologous recombination; exodeoxyribonuclease V (gamma chain), RecC complement(1172690..1175989) Mycobacterium marinum M 6225208 YP_001849271.1 CDS MMAR_0959 NC_010612.1 1176040 1176555 D nitroreductase 1176040..1176555 Mycobacterium marinum M 6225209 YP_001849272.1 CDS cynS NC_010612.1 1176629 1177105 D catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 1176629..1177105 Mycobacterium marinum M 6225210 YP_001849273.1 CDS MMAR_0961 NC_010612.1 1177128 1178132 D function unknown; predicted esterase domains; hypothetical protein 1177128..1178132 Mycobacterium marinum M 6225211 YP_001849274.1 CDS echA3 NC_010612.1 1178161 1178856 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1178161..1178856) Mycobacterium marinum M 6225212 YP_001849275.1 CDS MMAR_0963 NC_010612.1 1178938 1179768 R hypothetical protein complement(1178938..1179768) Mycobacterium marinum M 6225213 YP_001849276.1 CDS gloB NC_010612.1 1179962 1180678 R thought to be involved in glyoxal pathway. thioesterase that catalyses the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy acid anion]; glyoxalase II, GloB complement(1179962..1180678) Mycobacterium marinum M 6225214 YP_001849277.1 CDS MMAR_0966 NC_010612.1 1180811 1181020 D domain homology to Arc/MetJ class transcription regulators; hypothetical protein 1180811..1181020 Mycobacterium marinum M 6225215 YP_001849278.1 CDS rpmG NC_010612.1 1181408 1181575 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 1181408..1181575 Mycobacterium marinum M 6225218 YP_001849279.1 CDS MMAR_0968 NC_010612.1 1181626 1182105 D functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 1181626..1182105 Mycobacterium marinum M 6225219 YP_001849280.1 CDS MMAR_0969 NC_010612.1 1182092 1182520 D functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 1182092..1182520 Mycobacterium marinum M 6225220 YP_001849281.1 CDS MMAR_0970 NC_010612.1 1182531 1183031 D functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 1182531..1183031 Mycobacterium marinum M 6225221 YP_001849282.1 CDS secE NC_010612.1 1183400 1183888 D forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1183400..1183888 Mycobacterium marinum M 6225223 YP_001849283.1 CDS nusG NC_010612.1 1183920 1184633 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1183920..1184633 Mycobacterium marinum M 6225224 YP_001849284.1 CDS rplK NC_010612.1 1184680 1185108 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 1184680..1185108 Mycobacterium marinum M 6225225 YP_001849285.1 CDS rplA NC_010612.1 1185196 1185903 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 1185196..1185903 Mycobacterium marinum M 6225226 YP_001849286.1 CDS MMAR_0975 NC_010612.1 1185990 1187216 R RNA polymerase sigma factor complement(1185990..1187216) Mycobacterium marinum M 6225227 YP_001849287.1 CDS MMAR_0976 NC_010612.1 1187232 1187930 R May play a role in initiation of transcription; hypothetical protein complement(1187232..1187930) Mycobacterium marinum M 6225228 YP_001849288.1 CDS mmaA4 NC_010612.1 1188035 1188934 R methyltransferase. involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine- dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 4, MmaA4 complement(1188035..1188934) Mycobacterium marinum M 6225229 YP_001849289.1 CDS mmaA3 NC_010612.1 1189077 1189958 R methyltransferase involved in mycolic acid biosynthesis; methoxy mycolic acid synthase 3, MmaA3 complement(1189077..1189958) Mycobacterium marinum M 6225230 YP_001849290.1 CDS mmaA5_1 NC_010612.1 1190091 1190957 R involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 5 MmaA5 complement(1190091..1190957) Mycobacterium marinum M 6225231 YP_001849291.1 CDS mmaA1 NC_010612.1 1191104 1191964 R involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 1 Mma1 complement(1191104..1191964) Mycobacterium marinum M 6225232 YP_001849292.1 CDS lipG1 NC_010612.1 1192061 1193005 R lipase/esterase complement(1192061..1193005) Mycobacterium marinum M 6225233 YP_001849293.1 CDS MMAR_0982 NC_010612.1 1193015 1194400 R contains a kinase domain and ATP-binding cassette; hypothetical protein complement(1193015..1194400) Mycobacterium marinum M 6225234 YP_001849294.1 CDS lipG2 NC_010612.1 1194520 1195449 R lipase/esterase complement(1194520..1195449) Mycobacterium marinum M 6225235 YP_001849295.1 CDS amiD NC_010612.1 1195500 1196900 R amidase complement(1195500..1196900) Mycobacterium marinum M 6225236 YP_001849296.1 CDS MMAR_0985 NC_010612.1 1197027 1201226 D alpha-mannosidase activity: hydrolysis of terminal non-reducing alpha-D-mannose residues in alpha-D- mannosides; alpha-mannosidase 1197027..1201226 Mycobacterium marinum M 6225237 YP_001849297.1 CDS fabD2 NC_010612.1 1201223 1201840 D involved in lipid metabolism; fatty acid biosynthesis [catalytic activity: malonyl-CoA + [acyl- carrier protein] = CoA + malonyl-[acyl-carrier protein]]; malonyl CoA-acyl carrier protein transacylase, FabD2 1201223..1201840 Mycobacterium marinum M 6225238 YP_001849298.1 CDS MMAR_0987 NC_010612.1 1201847 1202755 D potential pseudogene due to C-term disruption by ISMyma04; function unknown; probably involved in specific sugar metabolism or regulation; carbohydrate kinase 1201847..1202755 Mycobacterium marinum M 6225239 YP_001849299.1 CDS MMAR_0988 NC_010612.1 1202766 1203737 R transposition of ISMyma04; transposase for ISMyma04 complement(1202766..1203737) Mycobacterium marinum M 6225240 YP_001849300.1 CDS MMAR_0989 NC_010612.1 1204266 1207418 D PE-PGRS family protein 1204266..1207418 Mycobacterium marinum M 6225241 YP_001849301.1 CDS rplJ NC_010612.1 1207793 1208413 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1207793..1208413 Mycobacterium marinum M 6225242 YP_001849302.1 CDS rplL NC_010612.1 1208481 1208873 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1208481..1208873 Mycobacterium marinum M 6225243 YP_001849303.1 CDS MMAR_0992 NC_010612.1 1208937 1209674 R function unknown, involved in transcriptional mechanism; transcriptional regulatory protein complement(1208937..1209674) Mycobacterium marinum M 6225244 YP_001849304.1 CDS MMAR_0993 NC_010612.1 1209746 1211248 D dioxygenase and related enzymes [secondary metabolites biosynthesis, transport, and catabolism]; dioxygenase 1209746..1211248 Mycobacterium marinum M 6225245 YP_001849305.1 CDS mkl NC_010612.1 1211427 1212413 D thought to be involved in active transport of ribonucleotide across the membrane. responsible for energy coupling to the transport system; ribonucleotide-transport ATP-binding protein ABC transporter, Mkl 1211427..1212413 Mycobacterium marinum M 6225246 YP_001849306.1 CDS rpoB NC_010612.1 1213006 1216536 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1213006..1216536 Mycobacterium marinum M 6225247 YP_001849307.1 CDS rpoC NC_010612.1 1216589 1220539 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1216589..1220539 Mycobacterium marinum M 6225248 YP_001849308.1 CDS MMAR_5546 NC_010612.1 1221202 1221393 D PE-PGRS family protein 1221202..1221393 Mycobacterium marinum M 6225249 YP_001849309.1 CDS MMAR_0997 NC_010612.1 1221426 1223339 R ceramidase complement(1221426..1223339) Mycobacterium marinum M 6225250 YP_001849310.1 CDS MMAR_0998 NC_010612.1 1223537 1224403 D hypothetical protein 1223537..1224403 Mycobacterium marinum M 6225251 YP_001849311.1 CDS end NC_010612.1 1224484 1225242 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 1224484..1225242 Mycobacterium marinum M 6225252 YP_001849312.1 CDS lpqP NC_010612.1 1225307 1226155 D lipoprotein LpqP 1225307..1226155 Mycobacterium marinum M 6225253 YP_001849313.1 CDS MMAR_1001 NC_010612.1 1226217 1227845 D may be involved in lipid degradation; acyl-CoA dehydrogenase 1226217..1227845 Mycobacterium marinum M 6225254 YP_001849314.1 CDS echA4 NC_010612.1 1227854 1228792 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1227854..1228792 Mycobacterium marinum M 6225255 YP_001849315.1 CDS MMAR_1003 NC_010612.1 1228806 1229537 D high domain identity with transcriptional repressors; putative regulatory protein 1228806..1229537 Mycobacterium marinum M 6225256 YP_001849316.1 CDS echA5 NC_010612.1 1229534 1230307 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1229534..1230307 Mycobacterium marinum M 6225257 YP_001849317.1 CDS mmpL5 NC_010612.1 1230364 1233258 R thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(1230364..1233258) Mycobacterium marinum M 6225258 YP_001849318.1 CDS mmpS5 NC_010612.1 1233255 1233683 R transmembrane proteinm, MmpS5 complement(1233255..1233683) Mycobacterium marinum M 6225259 YP_001849319.1 CDS MMAR_1007 NC_010612.1 1233867 1234367 D transcriptional regulator 1233867..1234367 Mycobacterium marinum M 6225260 YP_001849320.1 CDS MMAR_1008 NC_010612.1 1234417 1234893 R hypothetical protein complement(1234417..1234893) Mycobacterium marinum M 6225261 YP_001849321.1 CDS MMAR_1009 NC_010612.1 1234943 1235320 R hypothetical protein complement(1234943..1235320) Mycobacterium marinum M 6225262 YP_001849322.1 CDS MMAR_1010 NC_010612.1 1235584 1236231 D involved in transcriptional mechanism; TetR family transcriptional regulator 1235584..1236231 Mycobacterium marinum M 6225263 YP_001849323.1 CDS rpsL NC_010612.1 1236607 1236981 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 1236607..1236981 Mycobacterium marinum M 6225264 YP_001849324.1 CDS rpsG NC_010612.1 1236981 1237451 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 1236981..1237451 Mycobacterium marinum M 6225265 YP_001849325.1 CDS fusA1 NC_010612.1 1237532 1239637 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 1237532..1239637 Mycobacterium marinum M 6225266 YP_001849326.1 CDS tuf NC_010612.1 1239824 1241014 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1239824..1241014 Mycobacterium marinum M 6225267 YP_001849327.1 CDS MMAR_1015 NC_010612.1 1241264 1242073 D hypothetical protein 1241264..1242073 Mycobacterium marinum M 6225268 YP_001849328.1 CDS MMAR_1016 NC_010612.1 1242207 1243034 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1242207..1243034 Mycobacterium marinum M 6225269 YP_001849329.1 CDS MMAR_1017 NC_010612.1 1243044 1244282 D ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin reductase 1243044..1244282 Mycobacterium marinum M 6225270 YP_001849330.1 CDS MMAR_1018 NC_010612.1 1244381 1245442 R hypothetical protein complement(1244381..1245442) Mycobacterium marinum M 6225271 YP_001849331.1 CDS MMAR_1019 NC_010612.1 1245442 1246035 R involved in transcriptional mechanism; transcriptional regulator complement(1245442..1246035) Mycobacterium marinum M 6225272 YP_001849332.1 CDS MMAR_1020 NC_010612.1 1246252 1246563 D hypothetical protein 1246252..1246563 Mycobacterium marinum M 6225273 YP_001849333.1 CDS pqqE NC_010612.1 1246560 1247735 D required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis; coenzyme PQQ synthesis protein E, PqqE 1246560..1247735 Mycobacterium marinum M 6225274 YP_001849334.1 CDS lldD1 NC_010612.1 1247738 1248910 D involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]; L-lactate dehydrogenase (cytochrome) LldD1 1247738..1248910 Mycobacterium marinum M 6225275 YP_001849335.1 CDS MMAR_1023 NC_010612.1 1249065 1249817 D catalyses the hydrolysis of creatinine to creatine; creatinine amidohydrolase 1249065..1249817 Mycobacterium marinum M 6225276 YP_001849336.1 CDS MMAR_1024 NC_010612.1 1249814 1251226 D membrane glycosyl transferase 1249814..1251226 Mycobacterium marinum M 6225277 YP_001849337.1 CDS MMAR_1025 NC_010612.1 1251235 1252671 D dehydrogenase 1251235..1252671 Mycobacterium marinum M 6225278 YP_001849338.1 CDS MMAR_1026 NC_010612.1 1252661 1253296 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(1252661..1253296) Mycobacterium marinum M 6225279 YP_001849339.1 CDS MMAR_1027 NC_010612.1 1253431 1255416 R N-term truncated compared to orthologues; PPE family protein complement(1253431..1255416) Mycobacterium marinum M 6225280 YP_001849340.1 CDS MMAR_1028 NC_010612.1 1256153 1260349 D PPE family protein 1256153..1260349 Mycobacterium marinum M 6225281 YP_001849341.1 CDS MMAR_1029 NC_010612.1 1260905 1262236 D lipase 1260905..1262236 Mycobacterium marinum M 6225282 YP_001849342.1 CDS MMAR_5549 NC_010612.1 1262169 1262489 D hypothetical protein 1262169..1262489 Mycobacterium marinum M 6225283 YP_001849343.1 CDS rpsJ NC_010612.1 1262780 1263085 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 1262780..1263085 Mycobacterium marinum M 6225284 YP_001849344.1 CDS rplC NC_010612.1 1263100 1263753 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 1263100..1263753 Mycobacterium marinum M 6225285 YP_001849345.1 CDS rplD NC_010612.1 1263753 1264427 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1263753..1264427 Mycobacterium marinum M 6225286 YP_001849346.1 CDS rplW NC_010612.1 1264427 1264729 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 1264427..1264729 Mycobacterium marinum M 6225287 YP_001849347.1 CDS rplB NC_010612.1 1264759 1265601 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1264759..1265601 Mycobacterium marinum M 6225288 YP_001849348.1 CDS rpsS NC_010612.1 1265623 1265904 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1265623..1265904 Mycobacterium marinum M 6225289 YP_001849349.1 CDS rplV NC_010612.1 1265933 1266463 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 1265933..1266463 Mycobacterium marinum M 6225290 YP_001849350.1 CDS rpsC NC_010612.1 1266463 1267290 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 1266463..1267290 Mycobacterium marinum M 6225291 YP_001849351.1 CDS rplP NC_010612.1 1267294 1267710 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 1267294..1267710 Mycobacterium marinum M 6225292 YP_001849352.1 CDS rpmC NC_010612.1 1267710 1267952 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 1267710..1267952 Mycobacterium marinum M 6225293 YP_001849353.1 CDS rpsQ NC_010612.1 1267952 1268311 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 1267952..1268311 Mycobacterium marinum M 6225294 YP_001849354.1 CDS atsA NC_010612.1 1268455 1270824 D arylsulfatase AtsA 1268455..1270824 Mycobacterium marinum M 6225295 YP_001849355.1 CDS MMAR_1042 NC_010612.1 1270778 1271482 D hypothetical protein 1270778..1271482 Mycobacterium marinum M 6225296 YP_001849356.1 CDS MMAR_1043 NC_010612.1 1271487 1272368 D hypothetical protein 1271487..1272368 Mycobacterium marinum M 6225297 YP_001849357.1 CDS MMAR_1044 NC_010612.1 1272498 1273436 D transmembrane protein 1272498..1273436 Mycobacterium marinum M 6225298 YP_001849358.1 CDS rplN NC_010612.1 1273687 1274055 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 1273687..1274055 Mycobacterium marinum M 6225299 YP_001849359.1 CDS rplX NC_010612.1 1274056 1274379 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 1274056..1274379 Mycobacterium marinum M 6225300 YP_001849360.1 CDS rplE NC_010612.1 1274376 1274948 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 1274376..1274948 Mycobacterium marinum M 6225301 YP_001849361.1 CDS rpsN NC_010612.1 1274953 1275138 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 1274953..1275138 Mycobacterium marinum M 6225302 YP_001849362.1 CDS rpsH NC_010612.1 1275215 1275613 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 1275215..1275613 Mycobacterium marinum M 6225303 YP_001849363.1 CDS rplF NC_010612.1 1275624 1276163 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 1275624..1276163 Mycobacterium marinum M 6225304 YP_001849364.1 CDS rplR NC_010612.1 1276166 1276573 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 1276166..1276573 Mycobacterium marinum M 6225305 YP_001849365.1 CDS rpsE NC_010612.1 1276611 1277285 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 1276611..1277285 Mycobacterium marinum M 6225306 YP_001849366.1 CDS rpmD NC_010612.1 1277282 1277500 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 1277282..1277500 Mycobacterium marinum M 6225307 YP_001849367.1 CDS rplO NC_010612.1 1277497 1277937 D late assembly protein; 50S ribosomal protein L15 1277497..1277937 Mycobacterium marinum M 6225308 YP_001849368.1 CDS MMAR_1055 NC_010612.1 1278005 1278931 R flavin-dependent oxidoreductase complement(1278005..1278931) Mycobacterium marinum M 6225309 YP_001849369.1 CDS ssp NC_010612.1 1279018 1280820 D involved in digestion of the cleaved signal peptides. this activity is necessary to maintain proper secretion of mature proteins across the membrane; protease IV, Ssp 1279018..1280820 Mycobacterium marinum M 6225310 YP_001849370.1 CDS MMAR_1057 NC_010612.1 1280817 1281731 R O-methyltransferase complement(1280817..1281731) Mycobacterium marinum M 6225311 YP_001849371.1 CDS MMAR_1058 NC_010612.1 1281751 1282653 R O-methyltransferase complement(1281751..1282653) Mycobacterium marinum M 6225312 YP_001849372.1 CDS MMAR_1059 NC_010612.1 1282650 1283624 R O-methyltransferase complement(1282650..1283624) Mycobacterium marinum M 6225313 YP_001849373.1 CDS MMAR_1062 NC_010612.1 1285864 1286544 R methyltransferase complement(1285864..1286544) Mycobacterium marinum M 6225315 YP_001849374.1 CDS MMAR_1063 NC_010612.1 1286618 1287478 D involved in transcriptional mechanism; transcriptional regulatory protein 1286618..1287478 Mycobacterium marinum M 6225316 YP_001849375.1 CDS fucA NC_010612.1 1287502 1288158 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(1287502..1288158) Mycobacterium marinum M 6225317 YP_001849376.1 CDS serA2 NC_010612.1 1288155 1289144 R involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis. catalyzes the oxidation of D-3-phosphoglycerate to 3- phosphohydroxypyruvate [catalytic activity: 3- phosphoglycerate + NAD(+) = 3-phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase complement(1288155..1289144) Mycobacterium marinum M 6225318 YP_001849377.1 CDS xylB NC_010612.1 1289175 1290533 D phosphorylates D-xylulose [catalytic activity: ATP + D-xylulose = ADP + D-xylulose 5-phosphate]; D-xylulose-kinase (xylulokinase), XylB 1289175..1290533 Mycobacterium marinum M 6225319 YP_001849378.1 CDS MMAR_1067 NC_010612.1 1290681 1291346 D hypothetical protein 1290681..1291346 Mycobacterium marinum M 6225320 YP_001849379.1 CDS MMAR_1068 NC_010612.1 1291397 1292305 R O-methyltransferase complement(1291397..1292305) Mycobacterium marinum M 6225321 YP_001849380.1 CDS MMAR_1069 NC_010612.1 1292322 1293272 R O-methyltransferase complement(1292322..1293272) Mycobacterium marinum M 6225322 YP_001849381.1 CDS secY NC_010612.1 1293539 1294864 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1293539..1294864 Mycobacterium marinum M 6225323 YP_001849382.1 CDS adk NC_010612.1 1294861 1295406 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 1294861..1295406 Mycobacterium marinum M 6225324 YP_001849383.1 CDS mapA NC_010612.1 1295409 1296209 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 1295409..1296209 Mycobacterium marinum M 6225325 YP_001849384.1 CDS sigL NC_010612.1 1296262 1296795 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins; RNA polymerase sigma factor SigL 1296262..1296795 Mycobacterium marinum M 6225326 YP_001849385.1 CDS MMAR_1074 NC_010612.1 1296874 1297620 D function unknown, domain identity suggests possible role in transcription regulation; hypothetical protein 1296874..1297620 Mycobacterium marinum M 6225327 YP_001849386.1 CDS MMAR_1075 NC_010612.1 1297707 1298207 D involved in transcriptional mechanism; transcriptional regulator 1297707..1298207 Mycobacterium marinum M 6225328 YP_001849387.1 CDS MMAR_1076 NC_010612.1 1298231 1298779 D hypothetical protein 1298231..1298779 Mycobacterium marinum M 6225329 YP_001849388.1 CDS mmsB NC_010612.1 1298792 1299676 R catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3- oxopropanoate + NADH]; 3-hydroxyisobutyrate dehydrogenase complement(1298792..1299676) Mycobacterium marinum M 6225330 YP_001849389.1 CDS fadE9 NC_010612.1 1299689 1300861 R lipid metabolism; acyl-CoA dehydrogenase, FadE9 complement(1299689..1300861) Mycobacterium marinum M 6225331 YP_001849390.1 CDS mmsA NC_010612.1 1300867 1302387 R plays a role in valine and pyrimidine metabolism. binds fatty acyl-CoA [catalytic activity: 2-methyl-3- oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH]; methylmalonate semialdehyde dehydrogenase, MmsA complement(1300867..1302387) Mycobacterium marinum M 6225332 YP_001849391.1 CDS MMAR_1080 NC_010612.1 1302567 1304129 R transmembrane carbohydrate transport protein complement(1302567..1304129) Mycobacterium marinum M 6225333 YP_001849392.1 CDS rmlC NC_010612.1 1304293 1304898 R involved in dTDP-L-rhamnose biosynthesis, within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis: conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-rhamnose [catalytic activity: DTDP-4- dehydro-6-deoxy-D-glucose = DTDP-4-dehydro-6-deoxy-L- mannose]; dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC complement(1304293..1304898) Mycobacterium marinum M 6225334 YP_001849393.1 CDS rmlB NC_010612.1 1304900 1305895 R involved in dTDP-L-rhamnose biosynthesis [catalytic activity: dTDP-glucose = DTDP-4-dehydro-6-deoxy-D-glucose + H(2)O]; dTDP-glucose-4,6-dehydratase, RmlB complement(1304900..1305895) Mycobacterium marinum M 6225335 YP_001849394.1 CDS MMAR_1083 NC_010612.1 1305905 1306765 R hypothetical protein complement(1305905..1306765) Mycobacterium marinum M 6225336 YP_001849395.1 CDS MMAR_1084 NC_010612.1 1306792 1307688 R hypothetical protein complement(1306792..1307688) Mycobacterium marinum M 6225337 YP_001849396.1 CDS infA NC_010612.1 1307936 1308157 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1307936..1308157 Mycobacterium marinum M 6225338 YP_001849397.1 CDS rpmJ NC_010612.1 1308191 1308304 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 1308191..1308304 Mycobacterium marinum M 6225339 YP_001849398.1 CDS rpsM NC_010612.1 1308495 1308869 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 1308495..1308869 Mycobacterium marinum M 6225340 YP_001849399.1 CDS rpsK NC_010612.1 1308873 1309289 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 1308873..1309289 Mycobacterium marinum M 6225341 YP_001849400.1 CDS rpsD NC_010612.1 1309308 1309913 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1309308..1309913 Mycobacterium marinum M 6225342 YP_001849401.1 CDS rpoA NC_010612.1 1309999 1311042 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1309999..1311042 Mycobacterium marinum M 6225343 YP_001849402.1 CDS rplQ NC_010612.1 1311103 1311672 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 1311103..1311672 Mycobacterium marinum M 6225344 YP_001849403.1 CDS truA NC_010612.1 1311803 1312516 D mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1311803..1312516 Mycobacterium marinum M 6225345 YP_001849404.1 CDS cycA NC_010612.1 1312532 1314007 R permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-serine/D-alanine/glycine transporter, CycA complement(1312532..1314007) Mycobacterium marinum M 6225346 YP_001849405.1 CDS MMAR_1094 NC_010612.1 1314278 1315420 R PPE family protein complement(1314278..1315420) Mycobacterium marinum M 6225347 YP_001849406.1 CDS MMAR_1095 NC_010612.1 1315487 1316683 R PPE family protein complement(1315487..1316683) Mycobacterium marinum M 6225348 YP_001849407.1 CDS MMAR_1096 NC_010612.1 1316812 1318470 R similar to other proteins involved in nucleotide transport; hypothetical protein complement(1316812..1318470) Mycobacterium marinum M 6225349 YP_001849408.1 CDS cut4 NC_010612.1 1318730 1319425 R hydrolysis of cutin (a polyester that forms the structure of plant cuticle); cutinase complement(1318730..1319425) Mycobacterium marinum M 6225350 YP_001849409.1 CDS cut3 NC_010612.1 1319457 1320260 R cutinase complement(1319457..1320260) Mycobacterium marinum M 6225351 YP_001849410.1 CDS MMAR_1099 NC_010612.1 1320373 1321881 D hypothetical protein 1320373..1321881 Mycobacterium marinum M 6225352 YP_001849411.1 CDS mycP4 NC_010612.1 1321771 1323144 R membrane-anchored serine protease (mycosin), MycP4 complement(1321771..1323144) Mycobacterium marinum M 6225353 YP_001849412.1 CDS MMAR_1101 NC_010612.1 1323141 1324523 R hypothetical protein complement(1323141..1324523) Mycobacterium marinum M 6225354 YP_001849413.1 CDS MMAR_1102 NC_010612.1 1324638 1328318 D function unknown but has 3 ATP binding P-loop motifs; hypothetical protein 1324638..1328318 Mycobacterium marinum M 6225355 YP_001849414.1 CDS MMAR_1103 NC_010612.1 1328315 1329559 D hypothetical protein 1328315..1329559 Mycobacterium marinum M 6225356 YP_001849415.1 CDS esxU NC_010612.1 1329622 1329975 D EsaT-6 like protein, EsxU 1329622..1329975 Mycobacterium marinum M 6225357 YP_001849416.1 CDS esxT NC_010612.1 1329991 1330287 D EsaT-6 like protein, EsxT 1329991..1330287 Mycobacterium marinum M 6225358 YP_001849417.1 CDS rplM NC_010612.1 1330526 1330969 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1330526..1330969 Mycobacterium marinum M 6225359 YP_001849418.1 CDS rpsI NC_010612.1 1330966 1331424 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1330966..1331424 Mycobacterium marinum M 6225360 YP_001849419.1 CDS glmM NC_010612.1 1331575 1332912 D catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1331575..1332912 Mycobacterium marinum M 6225361 YP_001849420.1 CDS MMAR_1109 NC_010612.1 1333017 1333328 D hypothetical protein 1333017..1333328 Mycobacterium marinum M 6225362 YP_001849421.1 CDS MMAR_1110 NC_010612.1 1333331 1334728 D hypothetical protein 1333331..1334728 Mycobacterium marinum M 6225363 YP_001849422.1 CDS MMAR_1111 NC_010612.1 1334755 1335798 R function unknown but domain identity with flavin- dependent oxidoreductases; coenzyme F420-dependent oxidoreductase complement(1334755..1335798) Mycobacterium marinum M 6225364 YP_001849423.1 CDS MMAR_1112 NC_010612.1 1335814 1336653 R hydrolase domain identity; hypothetical protein complement(1335814..1336653) Mycobacterium marinum M 6225365 YP_001849424.1 CDS MMAR_1113 NC_010612.1 1336663 1337133 R hypothetical protein complement(1336663..1337133) Mycobacterium marinum M 6225366 YP_001849425.1 CDS glmS NC_010612.1 1337246 1339123 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 1337246..1339123 Mycobacterium marinum M 6225367 YP_001849426.1 CDS MMAR_1115 NC_010612.1 1339188 1340030 D hypothetical protein 1339188..1340030 Mycobacterium marinum M 6225368 YP_001849427.1 CDS MMAR_1116 NC_010612.1 1340082 1340795 D hypothetical protein 1340082..1340795 Mycobacterium marinum M 6225369 YP_001849428.1 CDS MMAR_1117 NC_010612.1 1340814 1342247 D has domain identity with YjeF-related protein N- terminus and sugar kinases c-terminus; transmembrane protein 1340814..1342247 Mycobacterium marinum M 6225370 YP_001849429.1 CDS gadB NC_010612.1 1342284 1343669 D catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)]; glutamate decarboxylase 1342284..1343669 Mycobacterium marinum M 6225371 YP_001849430.1 CDS alr NC_010612.1 1343756 1344922 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1343756..1344922 Mycobacterium marinum M 6225372 YP_001849431.1 CDS MMAR_1120 NC_010612.1 1344912 1346033 D hydrolase 1344912..1346033 Mycobacterium marinum M 6225373 YP_001849432.1 CDS MMAR_1121 NC_010612.1 1346026 1346496 D ATPase domain; hypothetical protein 1346026..1346496 Mycobacterium marinum M 6225374 YP_001849433.1 CDS MMAR_1122 NC_010612.1 1346493 1347119 D peptidase; hypothetical protein 1346493..1347119 Mycobacterium marinum M 6225375 YP_001849434.1 CDS rimI NC_010612.1 1347116 1347592 D this enzyme acetylates the N-terminal alanine of ribosomal protein S18 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine]; ribosomal-protein-alanine acetyltransferase, RimI 1347116..1347592 Mycobacterium marinum M 6225376 YP_001849435.1 CDS gcp NC_010612.1 1347593 1348624 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 1347593..1348624 Mycobacterium marinum M 6225377 YP_001849436.1 CDS groES NC_010612.1 1348938 1349240 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1348938..1349240 Mycobacterium marinum M 6225378 YP_001849437.1 CDS groEL NC_010612.1 1349333 1350952 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; chaperonin GroEL 1349333..1350952 Mycobacterium marinum M 6225379 YP_001849438.1 CDS MMAR_1127 NC_010612.1 1351203 1352423 D possible transcriptional regulator; hypothetical protein 1351203..1352423 Mycobacterium marinum M 6225380 YP_001849439.1 CDS MMAR_1128 NC_010612.1 1352460 1352897 R hypothetical protein complement(1352460..1352897) Mycobacterium marinum M 6225381 YP_001849440.1 CDS MMAR_1129 NC_010612.1 1353163 1354878 R PPE family protein complement(1353163..1354878) Mycobacterium marinum M 6225382 YP_001849441.1 CDS MMAR_5550 NC_010612.1 1354964 1355446 D N-term truncation of 14 aa compared to M. ulcerans (frame shift mutation); hypothetical protein 1354964..1355446 Mycobacterium marinum M 6225383 YP_001849442.1 CDS MMAR_1130 NC_010612.1 1355427 1357121 R PPE family protein complement(1355427..1357121) Mycobacterium marinum M 6225384 YP_001849443.1 CDS MMAR_1131 NC_010612.1 1357453 1359108 D metal-dependent hydrolase 1357453..1359108 Mycobacterium marinum M 6225385 YP_001849444.1 CDS whiB3 NC_010612.1 1359154 1359462 R intracellular redox sensor that integrates environmental redox signals with core intermediary metabolism; WhiB-like regulatory protein, WhiB3 complement(1359154..1359462) Mycobacterium marinum M 6225386 YP_001849445.1 CDS MMAR_1133 NC_010612.1 1360001 1360873 D hypothetical protein 1360001..1360873 Mycobacterium marinum M 6225387 YP_001849446.1 CDS sigD NC_010612.1 1360949 1361542 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD 1360949..1361542 Mycobacterium marinum M 6225388 YP_001849447.1 CDS MMAR_1135 NC_010612.1 1361535 1362479 D hypothetical protein 1361535..1362479 Mycobacterium marinum M 6225389 YP_001849448.1 CDS MMAR_1136 NC_010612.1 1362643 1363056 R hypothetical protein complement(1362643..1363056) Mycobacterium marinum M 6225390 YP_001849449.1 CDS guaB2 NC_010612.1 1363220 1364818 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 1363220..1364818 Mycobacterium marinum M 6225391 YP_001849450.1 CDS guaB3 NC_010612.1 1364828 1365955 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 1364828..1365955 Mycobacterium marinum M 6225392 YP_001849451.1 CDS MMAR_1139 NC_010612.1 1366136 1367962 D PPE family protein 1366136..1367962 Mycobacterium marinum M 6225393 YP_001849452.1 CDS choD NC_010612.1 1368051 1369796 D involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)]; cholesterol oxidase ChoD 1368051..1369796 Mycobacterium marinum M 6225394 YP_001849453.1 CDS tauD NC_010612.1 1369822 1370718 R in E. coli this enzyme catalyses the oxygenolytic release of sulfite from taurine; taurine catabolism dioxygenase, TauD complement(1369822..1370718) Mycobacterium marinum M 6225395 YP_001849454.1 CDS MMAR_1142 NC_010612.1 1370845 1371354 D involved in transcriptional mechanism; transcriptional regulator 1370845..1371354 Mycobacterium marinum M 6225396 YP_001849455.1 CDS MMAR_1143 NC_010612.1 1371340 1373724 R similar to maltose phosphorylase, a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose; glycosyl hydrolase complement(1371340..1373724) Mycobacterium marinum M 6225397 YP_001849456.1 CDS MMAR_1144 NC_010612.1 1373721 1374461 R cellular metabolism; hydrolase complement(1373721..1374461) Mycobacterium marinum M 6225398 YP_001849457.1 CDS MMAR_5486 NC_010612.1 1374543 1375061 D hypothetical protein 1374543..1375061 Mycobacterium marinum M 6225399 YP_001849458.1 CDS MMAR_1145 NC_010612.1 1375100 1375717 D involved in transcriptional mechanism; transcriptional regulatory protein 1375100..1375717 Mycobacterium marinum M 6225400 YP_001849459.1 CDS MMAR_1146 NC_010612.1 1375714 1377270 R integral membrane transport protein complement(1375714..1377270) Mycobacterium marinum M 6225401 YP_001849460.1 CDS MMAR_1147 NC_010612.1 1377349 1378032 D involved in transcriptional mechanism; transcriptional regulatory protein 1377349..1378032 Mycobacterium marinum M 6225402 YP_001849461.1 CDS guaA NC_010612.1 1378111 1379688 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1378111..1379688 Mycobacterium marinum M 6225403 YP_001849462.1 CDS MMAR_1149 NC_010612.1 1379744 1380433 R hypothetical protein complement(1379744..1380433) Mycobacterium marinum M 6225404 YP_001849463.1 CDS MMAR_1150 NC_010612.1 1380541 1381200 D hypothetical protein 1380541..1381200 Mycobacterium marinum M 6225405 YP_001849464.1 CDS MMAR_1151 NC_010612.1 1381207 1382778 D function unknown but belongs to the DNA/RNA polymerase superfamily; hypothetical protein 1381207..1382778 Mycobacterium marinum M 6225406 YP_001849465.1 CDS iunH NC_010612.1 1382851 1383801 R involved in purine salvage. catalyzes the hydrolysis of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base, and could have a preference for inosine and uridine as substrates [catalytic activity: a N-D-ribosylpurine + H(2)O = a purine + d- ribose]; inosine-uridine nucleoside hydrolase, IunH complement(1382851..1383801) Mycobacterium marinum M 6225407 YP_001849466.1 CDS acrA1 NC_010612.1 1383846 1385858 R multifunctional protein with fatty acyl-CoA reductase activity in C-terminal part; short chain dehydrogenase complement(1383846..1385858) Mycobacterium marinum M 6225408 YP_001849467.1 CDS lpqD NC_010612.1 1385898 1386596 R lipoprotein LpqD complement(1385898..1386596) Mycobacterium marinum M 6225409 YP_001849468.1 CDS MMAR_1155 NC_010612.1 1386707 1387579 D may have dehydratase activity; contains a MaoC protein family domain; hypothetical protein 1386707..1387579 Mycobacterium marinum M 6225410 YP_001849469.1 CDS otsB2 NC_010612.1 1387593 1388765 R involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]; trehalose-6-phosphate phosphatase OtsB2 complement(1387593..1388765) Mycobacterium marinum M 6225411 YP_001849470.1 CDS MMAR_1157 NC_010612.1 1388817 1390151 R hypothetical protein complement(1388817..1390151) Mycobacterium marinum M 6225412 YP_001849471.1 CDS dnaE2 NC_010612.1 1390349 1393651 D DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase 1390349..1393651 Mycobacterium marinum M 6225413 YP_001849472.1 CDS MMAR_1159 NC_010612.1 1393727 1394137 R hypothetical protein complement(1393727..1394137) Mycobacterium marinum M 6225414 YP_001849473.1 CDS MMAR_1160 NC_010612.1 1394170 1394814 D function unknown, probably involved in cellular metabolism; nitroreductase 1394170..1394814 Mycobacterium marinum M 6225415 YP_001849474.1 CDS MMAR_1161 NC_010612.1 1394826 1396610 R PE-PGRS family protein complement(1394826..1396610) Mycobacterium marinum M 6225416 YP_001849475.1 CDS MMAR_1162 NC_010612.1 1396735 1398516 R PE-PGRS family protein complement(1396735..1398516) Mycobacterium marinum M 6225417 YP_001849476.1 CDS spoU NC_010612.1 1398697 1399161 R involved in rRNA methylation; tRNA/rRNA methyltransferase SpoU complement(1398697..1399161) Mycobacterium marinum M 6225418 YP_001849477.1 CDS MMAR_1164 NC_010612.1 1399229 1399834 D function unknown but may be involved in RNA methylation; methyltransferase 1399229..1399834 Mycobacterium marinum M 6225419 YP_001849478.1 CDS MMAR_1165 NC_010612.1 1400051 1402786 D function unknown but may be a regulatory protein as it contains a signal transduction histidine kinase domain; putative regultory protein 1400051..1402786 Mycobacterium marinum M 6225420 YP_001849479.1 CDS MMAR_1166 NC_010612.1 1402783 1403214 D hypothetical protein 1402783..1403214 Mycobacterium marinum M 6225421 YP_001849480.1 CDS MMAR_1167 NC_010612.1 1403190 1403576 D hypothetical protein 1403190..1403576 Mycobacterium marinum M 6225422 YP_001849481.1 CDS MMAR_1168 NC_010612.1 1403557 1404159 D GTP/ATP-binding protein 1403557..1404159 Mycobacterium marinum M 6225423 YP_001849482.1 CDS MMAR_1169 NC_010612.1 1404168 1404716 D hypothetical protein 1404168..1404716 Mycobacterium marinum M 6225424 YP_001849483.1 CDS fadD29_1 NC_010612.1 1405360 1407351 D function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD29 1405360..1407351 Mycobacterium marinum M 6225425 YP_001849484.1 CDS bioF2_5 NC_010612.1 1407389 1409836 D could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase 1407389..1409836 Mycobacterium marinum M 6225426 YP_001849485.1 CDS MMAR_1172 NC_010612.1 1409841 1411142 D function unknown, probably involved in cellular metabolism; dehydrogenase 1409841..1411142 Mycobacterium marinum M 6225427 YP_001849486.1 CDS MMAR_1173 NC_010612.1 1411186 1413711 R thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein complement(1411186..1413711) Mycobacterium marinum M 6225428 YP_001849487.1 CDS MMAR_1174 NC_010612.1 1413736 1416357 R thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein complement(1413736..1416357) Mycobacterium marinum M 6225429 YP_001849488.1 CDS MMAR_1175 NC_010612.1 1416734 1417927 R function unknown; probably involved in cellular metabolism; oxidoreductase complement(1416734..1417927) Mycobacterium marinum M 6225430 YP_001849489.1 CDS folD NC_010612.1 1418035 1418880 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 1418035..1418880 Mycobacterium marinum M 6225431 YP_001849490.1 CDS MMAR_1177 NC_010612.1 1418877 1419170 D hypothetical protein 1418877..1419170 Mycobacterium marinum M 6225432 YP_001849491.1 CDS MMAR_1178 NC_010612.1 1419174 1419590 R hypothetical protein complement(1419174..1419590) Mycobacterium marinum M 6225433 YP_001849492.1 CDS MMAR_1179 NC_010612.1 1419844 1421286 D function unknown, probably involved in cellular metabolism; oxidoreductase 1419844..1421286 Mycobacterium marinum M 6225434 YP_001849493.1 CDS MMAR_1180 NC_010612.1 1421534 1431313 D N-term fused in-frame with fatty acyl-AMP ligase FadD28_1; Synthesis of unknown polyketide; Fatty acyl-AMP ligase FadD28 and polyketide synthase 1421534..1431313 Mycobacterium marinum M 6225435 YP_001849494.1 CDS MMAR_1181 NC_010612.1 1431353 1431649 R hypothetical protein complement(1431353..1431649) Mycobacterium marinum M 6225436 YP_001849495.1 CDS MMAR_1182 NC_010612.1 1431711 1432139 R exported protein complement(1431711..1432139) Mycobacterium marinum M 6225437 YP_001849496.1 CDS MMAR_1183 NC_010612.1 1432198 1432932 R causes methylation; methyltransferase complement(1432198..1432932) Mycobacterium marinum M 6225438 YP_001849497.1 CDS metX NC_010612.1 1432929 1434068 R Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase complement(1432929..1434068) Mycobacterium marinum M 6225439 YP_001849498.1 CDS metC NC_010612.1 1434080 1435429 R catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase complement(1434080..1435429) Mycobacterium marinum M 6225440 YP_001849499.1 CDS icd1 NC_010612.1 1435744 1436970 D Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1435744..1436970 Mycobacterium marinum M 6225441 YP_001849500.1 CDS MMAR_1187 NC_010612.1 1436981 1437781 R hypothetical protein complement(1436981..1437781) Mycobacterium marinum M 6225442 YP_001849501.1 CDS trpS NC_010612.1 1437939 1438958 D catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1437939..1438958 Mycobacterium marinum M 6225443 YP_001849502.1 CDS MMAR_1189 NC_010612.1 1438963 1439991 D integral membrane protein 1438963..1439991 Mycobacterium marinum M 6225444 YP_001849503.1 CDS nagA NC_010612.1 1439988 1441154 R involved in N-acetyl glucosamine utilization pathway [catalytic activity: N-acetyl-D-glucosamine 6- phosphate + H(2)O = D-glucosamine 6-phosphate + acetate]; N-acetylglucosamine-6-phosphate deacetylase NagA complement(1439988..1441154) Mycobacterium marinum M 6225445 YP_001849504.1 CDS sugI NC_010612.1 1441151 1442500 R thought to be involved in transport of sugar across the membrane. responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein SugI complement(1441151..1442500) Mycobacterium marinum M 6225446 YP_001849505.1 CDS dacC NC_010612.1 1442702 1443949 R involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; penicillin-binding protein DacC complement(1442702..1443949) Mycobacterium marinum M 6225447 YP_001849506.1 CDS MMAR_1193 NC_010612.1 1444116 1444709 D transcriptional regulator 1444116..1444709 Mycobacterium marinum M 6225448 YP_001849507.1 CDS MMAR_1194 NC_010612.1 1444699 1447017 D possible inter-alpha-trypsin inhibitor family heavy chain-related protein-hypothetical secreted or membrane- associated protein containing vWFA domain; hypothetical protein 1444699..1447017 Mycobacterium marinum M 6225449 YP_001849508.1 CDS MMAR_1195 NC_010612.1 1447038 1449683 R PE-PGRS family protein complement(1447038..1449683) Mycobacterium marinum M 6225450 YP_001849509.1 CDS sigJ NC_010612.1 1449985 1450914 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigJ 1449985..1450914 Mycobacterium marinum M 6225451 YP_001849510.1 CDS MMAR_1197 NC_010612.1 1450964 1451563 R hypothetical protein complement(1450964..1451563) Mycobacterium marinum M 6225452 YP_001849511.1 CDS MMAR_1198 NC_010612.1 1451666 1452109 D hypothetical protein 1451666..1452109 Mycobacterium marinum M 6225453 YP_001849512.1 CDS MMAR_1199 NC_010612.1 1452323 1457155 D PE-PGRS family protein 1452323..1457155 Mycobacterium marinum M 6225454 YP_001849513.1 CDS sdhB NC_010612.1 1457167 1457979 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit complement(1457167..1457979) Mycobacterium marinum M 6225455 YP_001849514.1 CDS sdhA NC_010612.1 1457979 1459733 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit complement(1457979..1459733) Mycobacterium marinum M 6225456 YP_001849515.1 CDS sdhD NC_010612.1 1459762 1460229 R involved in tricarboxylic acid cycle. putative hydrophobic component of the succinate dehydrogenase complex. could be required to anchor the catalytic components to the cytoplasmic membrane; succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD complement(1459762..1460229) Mycobacterium marinum M 6225457 YP_001849516.1 CDS sdhC NC_010612.1 1460226 1460564 R involved in tricarboxylic acid cycle. mono-heme cytochrome of the succinate dehydrogenase complex; succinate dehydrogenase (cytochrome B-556 subunit) SdhC complement(1460226..1460564) Mycobacterium marinum M 6225458 YP_001849517.1 CDS cdd NC_010612.1 1460868 1461266 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 1460868..1461266 Mycobacterium marinum M 6225459 YP_001849518.1 CDS deoA NC_010612.1 1461263 1462564 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 1461263..1462564 Mycobacterium marinum M 6225460 YP_001849519.1 CDS add NC_010612.1 1462561 1463649 D catalyzes the formation of inosine from adenosine; adenosine deaminase 1462561..1463649 Mycobacterium marinum M 6225461 YP_001849520.1 CDS MMAR_1207 NC_010612.1 1463658 1466498 R PE-PGRS family protein complement(1463658..1466498) Mycobacterium marinum M 6225462 YP_001849521.1 CDS MMAR_1208 NC_010612.1 1466768 1469659 R PE-PGRS family protein complement(1466768..1469659) Mycobacterium marinum M 6225463 YP_001849522.1 CDS MMAR_1209 NC_010612.1 1469836 1471092 D hypothetical protein 1469836..1471092 Mycobacterium marinum M 6225464 YP_001849523.1 CDS alc NC_010612.1 1471089 1472048 D catalyzes the formation of S-ureidoglycolate and urea from allantoate; allantoicase 1471089..1472048 Mycobacterium marinum M 6225465 YP_001849524.1 CDS MMAR_1211 NC_010612.1 1472045 1472956 D function unknown, contains xylanase/chitin deacetylase domain; chitinase 1472045..1472956 Mycobacterium marinum M 6225466 YP_001849525.1 CDS MMAR_1212 NC_010612.1 1472935 1474461 R function unknown but contains permease domain and may be involved in nucleotide transport (cytosine/purines) and metabolism/coenzyme metabolism; hypothetical protein complement(1472935..1474461) Mycobacterium marinum M 6225467 YP_001849526.1 CDS MMAR_1213 NC_010612.1 1474570 1476069 R function unknown. thought to be regulated by LexA; 13e12 repeat-containing protein complement(1474570..1476069) Mycobacterium marinum M 6225468 YP_001849527.1 CDS MMAR_1214 NC_010612.1 1476139 1477035 D function unknown but contains hydrolase domain; hypothetical protein 1476139..1477035 Mycobacterium marinum M 6225469 YP_001849528.1 CDS MMAR_1215 NC_010612.1 1477124 1478449 R hypothetical protein complement(1477124..1478449) Mycobacterium marinum M 6225470 YP_001849529.1 CDS MMAR_1216 NC_010612.1 1478498 1479385 R involved in cellular metabolism: acting on ester bonds [catalytic activity: an orthophosphoric monoester + H(2)O = an alcohol + orthophosphate]; acid phosphatase complement(1478498..1479385) Mycobacterium marinum M 6225471 YP_001849530.1 CDS upp NC_010612.1 1479477 1480100 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1479477..1480100 Mycobacterium marinum M 6225472 YP_001849531.1 CDS pmmB NC_010612.1 1480102 1481682 R converts D-mannose 1-phosphate to D-mannose 6- phosphate; phosphomannomutase complement(1480102..1481682) Mycobacterium marinum M 6225473 YP_001849532.1 CDS deoD NC_010612.1 1481672 1482493 R catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase complement(1481672..1482493) Mycobacterium marinum M 6225474 YP_001849533.1 CDS amiB1 NC_010612.1 1482576 1483757 D involved in cellular metabolism, active on carbon aliphatic amides and/or on many aromatic amides [catalytic activity : a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidohydrolase 1482576..1483757 Mycobacterium marinum M 6225475 YP_001849534.1 CDS amiA1 NC_010612.1 1483754 1484923 D function unknown, hydrolysis of L-amino acids; N-acyl-L-amino acid amidohydrolase AmiA1 1483754..1484923 Mycobacterium marinum M 6225476 YP_001849535.1 CDS MMAR_1222 NC_010612.1 1485035 1485922 D hypothetical protein 1485035..1485922 Mycobacterium marinum M 6225477 YP_001849536.1 CDS MMAR_1223 NC_010612.1 1486014 1486493 R hypothetical protein complement(1486014..1486493) Mycobacterium marinum M 6225478 YP_001849537.1 CDS lpdA NC_010612.1 1486638 1488047 D catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 1486638..1488047 Mycobacterium marinum M 6225479 YP_001849538.1 CDS glpD2 NC_010612.1 1488132 1489889 D involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor]; glycerol-3-phosphate dehydrogenase GlpD2 1488132..1489889 Mycobacterium marinum M 6225480 YP_001849539.1 CDS gltB_1 NC_010612.1 1490297 1491841 D function unknown but may be involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]; glutamate synthase, GltB 1490297..1491841 Mycobacterium marinum M 6225481 YP_001849540.1 CDS MMAR_1227 NC_010612.1 1491849 1492487 R hypothetical protein complement(1491849..1492487) Mycobacterium marinum M 6225482 YP_001849541.1 CDS ctpH_1 NC_010612.1 1492620 1497083 R metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporting p-type ATPase CtpH complement(1492620..1497083) Mycobacterium marinum M 6225483 YP_001849542.1 CDS phoY1 NC_010612.1 1497403 1498068 D involved in transcriptional regulation of active transport of inorganic phosphate across the membrane; phosphate-transport system transcriptional regulatory protein PhoY1 1497403..1498068 Mycobacterium marinum M 6225484 YP_001849543.1 CDS corA_1 NC_010612.1 1498110 1499108 D thought to be involved in transport of magnesium and cobalt ions across the membrane. responsible for the translocation of the substrate across the membrane; magnesium and cobalt transport transmembrane protein CorA 1498110..1499108 Mycobacterium marinum M 6225485 YP_001849544.1 CDS MMAR_1231 NC_010612.1 1499313 1500179 D catalyses the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); pseudouridine synthase 1499313..1500179 Mycobacterium marinum M 6225486 YP_001849545.1 CDS atsB NC_010612.1 1500201 1503104 D generates sulfate and phenol from phenol sulfate [catalytic activity: a phenol sulfate + H(2)O = a phenol + sulfate]; arylsulfatase AtsB 1500201..1503104 Mycobacterium marinum M 6225487 YP_001849546.1 CDS MMAR_1233 NC_010612.1 1503126 1503446 R hypothetical protein complement(1503126..1503446) Mycobacterium marinum M 6225488 YP_001849547.1 CDS phoS2_1 NC_010612.1 1503707 1504819 D involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport; periplasmic phosphate-binding lipoprotein PhoS2 1503707..1504819 Mycobacterium marinum M 6225489 YP_001849548.1 CDS MMAR_1235 NC_010612.1 1504905 1506035 D function unknown. possibly a protective antigen involved with the early control of infection; PPE family protein 1504905..1506035 Mycobacterium marinum M 6225490 YP_001849549.1 CDS lpqC NC_010612.1 1506088 1507005 D function unknown, lipolytic enzyme involved in cellular metabolism; esterase lipoprotein LpqC 1506088..1507005 Mycobacterium marinum M 6225491 YP_001849550.1 CDS nei NC_010612.1 1507020 1507784 R involved in damage reversal. DNA N-glycosylase with an ap lyase activity. required for the repair of oxidative DNA damage (oxidized pyrimidines); endonuclease VIII Nei complement(1507020..1507784) Mycobacterium marinum M 6225492 YP_001849551.1 CDS lhr NC_010612.1 1507788 1512407 R function unknown but has both ATPase and helicase activities; ATP-dependent helicase Lhr complement(1507788..1512407) Mycobacterium marinum M 6225493 YP_001849552.1 CDS MMAR_1239 NC_010612.1 1512440 1513114 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(1512440..1513114) Mycobacterium marinum M 6225494 YP_001849553.1 CDS pcd NC_010612.1 1513163 1514677 R involved in L-alpha-aminoadipic acid (L-AAA) biosynthesis (in the second step; the first step is promoted by Lat enzyme; piperideine-6-carboxilic acid dehydrogenase Pcd complement(1513163..1514677) Mycobacterium marinum M 6225495 YP_001849554.1 CDS MMAR_1241 NC_010612.1 1514755 1516026 R hypothetical protein complement(1514755..1516026) Mycobacterium marinum M 6225496 YP_001849555.1 CDS MMAR_1242 NC_010612.1 1516060 1516512 D involved in transcriptional mechanism; AsnC family transcriptional regulator 1516060..1516512 Mycobacterium marinum M 6225497 YP_001849556.1 CDS lat NC_010612.1 1516566 1517906 D catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate; L-lysine aminotransferase 1516566..1517906 Mycobacterium marinum M 6225498 YP_001849557.1 CDS MMAR_1244 NC_010612.1 1517986 1518372 D hypothetical protein 1517986..1518372 Mycobacterium marinum M 6225499 YP_001849558.1 CDS usfY NC_010612.1 1518485 1518796 D hypothetical protein 1518485..1518796 Mycobacterium marinum M 6225500 YP_001849559.1 CDS MMAR_1246 NC_010612.1 1518992 1519204 D hypothetical protein 1518992..1519204 Mycobacterium marinum M 6225501 YP_001849560.1 CDS rsbW NC_010612.1 1519201 1519719 D binds to sigma and blocks its ability to form an RNA polymerase holoenzyme. regulates negatively SigF and negatively regulated by RsfA and RsfB; anti-sigma factor RsbW 1519201..1519719 Mycobacterium marinum M 6225502 YP_001849561.1 CDS sigF NC_010612.1 1519716 1520504 D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock; RNA polymerase sigma factor SigF 1519716..1520504 Mycobacterium marinum M 6225503 YP_001849562.1 CDS MMAR_1249 NC_010612.1 1520566 1521135 R involved in transcriptional mechanism; transcriptional regulatory protein complement(1520566..1521135) Mycobacterium marinum M 6225504 YP_001849563.1 CDS MMAR_1250 NC_010612.1 1521763 1531236 D function unknown but contains 3 modules for the potential synthesis of a tripeptide; peptide synthetase Nrp (peptide synthase) 1521763..1531236 Mycobacterium marinum M 6225505 YP_001849564.1 CDS accA3 NC_010612.1 1531258 1533051 R involved in long-chain fatty acid synthesis (at the first step). carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein]; bifunctional protein acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA3 complement(1531258..1533051) Mycobacterium marinum M 6225506 YP_001849565.1 CDS sufE NC_010612.1 1533162 1533581 R probably involved in Fe-S center assembly; Fe-S metabolism associated protein, SufE complement(1533162..1533581) Mycobacterium marinum M 6225507 YP_001849566.1 CDS sseA NC_010612.1 1533578 1534483 R possibly a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]; thiosulfate sulfurtransferase SseA complement(1533578..1534483) Mycobacterium marinum M 6225508 YP_001849567.1 CDS MMAR_1254 NC_010612.1 1534523 1535173 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(1534523..1535173) Mycobacterium marinum M 6225509 YP_001849568.1 CDS MMAR_1255 NC_010612.1 1535170 1535490 R hypothetical protein complement(1535170..1535490) Mycobacterium marinum M 6225510 YP_001849569.1 CDS accD5 NC_010612.1 1535487 1537127 R key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.]; propionyl-CoA carboxylase beta chain 5 AccD5 complement(1535487..1537127) Mycobacterium marinum M 6225511 YP_001849570.1 CDS birA NC_010612.1 1537278 1538108 D BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl- CoA:carbon-dioxide ligase. this protein also activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [catalytic activity: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP forming)] = AMP + pyrophosphate + [acetyl- CoA:carbon-dioxide ligase (ADP forming)]]; bifunctional protein BirA 1537278..1538108 Mycobacterium marinum M 6225512 YP_001849571.1 CDS MMAR_1258 NC_010612.1 1538171 1538689 D hypothetical protein 1538171..1538689 Mycobacterium marinum M 6225513 YP_001849572.1 CDS MMAR_1259 NC_010612.1 1538644 1539288 R hypothetical protein complement(1538644..1539288) Mycobacterium marinum M 6225514 YP_001849573.1 CDS purK NC_010612.1 1539427 1540641 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1539427..1540641 Mycobacterium marinum M 6225515 YP_001849574.1 CDS purE NC_010612.1 1540634 1541149 D involved in purine biosynthesis (sixth step). this subunit can alone transform air to cair, but in association with PurK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting air to cair efficiently under physiol; phosphoribosylaminoimidazole carboxylase catalytic subunit PurE 1540634..1541149 Mycobacterium marinum M 6225516 YP_001849575.1 CDS fadE25 NC_010612.1 1541174 1542343 D function unknown, but involved in lipid metabolism [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]; acyl-CoA dehydrogenase FadE25 1541174..1542343 Mycobacterium marinum M 6225517 YP_001849576.1 CDS MMAR_1263 NC_010612.1 1542537 1543775 D hypothetical protein 1542537..1543775 Mycobacterium marinum M 6225518 YP_001849577.1 CDS MMAR_1264 NC_010612.1 1543772 1545394 D two-component system membrane associated sensor kinase 1543772..1545394 Mycobacterium marinum M 6225519 YP_001849578.1 CDS MMAR_1265 NC_010612.1 1545391 1545831 D sensor part of the two-component regulatory system; two-component transcriptional regulator 1545391..1545831 Mycobacterium marinum M 6225520 YP_001849579.1 CDS sulP_2 NC_010612.1 1545845 1548091 R generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane; transmembrane carbonic anhydrase, SulP_2 complement(1545845..1548091) Mycobacterium marinum M 6225521 YP_001849580.1 CDS MMAR_1267 NC_010612.1 1548369 1549556 R acyl-CoA transferase complement(1548369..1549556) Mycobacterium marinum M 6225522 YP_001849581.1 CDS MMAR_1268 NC_010612.1 1549733 1550389 R putative regulatory protein complement(1549733..1550389) Mycobacterium marinum M 6225523 YP_001849582.1 CDS MMAR_1269 NC_010612.1 1550462 1552168 D acyl esterase 1550462..1552168 Mycobacterium marinum M 6225524 YP_001849583.1 CDS MMAR_1270 NC_010612.1 1552229 1552948 D hypothetical protein 1552229..1552948 Mycobacterium marinum M 6225525 YP_001849584.1 CDS ctpC NC_010612.1 1552992 1555190 R metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation-transporting p-type ATPase CtpC complement(1552992..1555190) Mycobacterium marinum M 6225526 YP_001849585.1 CDS MMAR_1272 NC_010612.1 1555200 1555478 R function unknown; hypothetical protein complement(1555200..1555478) Mycobacterium marinum M 6225527 YP_001849586.1 CDS MMAR_1273 NC_010612.1 1555594 1556274 R hypothetical protein complement(1555594..1556274) Mycobacterium marinum M 6225528 YP_001849587.1 CDS MMAR_1274 NC_010612.1 1556304 1557761 R hypothetical protein complement(1556304..1557761) Mycobacterium marinum M 6225529 YP_001849588.1 CDS rmlD NC_010612.1 1557829 1558755 D involved in dTDP-L-rhamnose biosynthesis: converts dTDP-6-deoxy-L-lyxo-4-hexulose to dTDP-L-rhamnose with the concomitant oxidation of NADPH to NADP+ [catalytic activity: dTDP-6-deoxy-L-lyxo-4-hexulose + NADPH = dTDP-L- rhamnose + NADP+]; dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD 1557829..1558755 Mycobacterium marinum M 6225530 YP_001849589.1 CDS wbbL1 NC_010612.1 1558748 1559632 D involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall. seems to be essential for mycobacterial viability; dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3- L-rhamnosyl transferase, WbbL1 1558748..1559632 Mycobacterium marinum M 6225531 YP_001849590.1 CDS manB NC_010612.1 1559634 1560710 D involved in GDP-mannose biosynthesis and biosynthesis of nucleotide-activated glycero-manno-heptose (D-alpha-D pathway): generates GDP-mannose and phosphate from GTP and alpha-D-mannose 1-phosphate. ManB product is needed for all mannosyl glycolipids and polysaccharides which, like rhamnosyl residues, are an important part of the mycobacterium envelope [catalytic activity: alpha-D- mannose 1-phosphate + GTP = GDP-mannose + phosphate]; d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 1559634..1560710 Mycobacterium marinum M 6225532 YP_001849591.1 CDS MMAR_1278 NC_010612.1 1560739 1561287 R hypothetical protein complement(1560739..1561287) Mycobacterium marinum M 6225533 YP_001849592.1 CDS MMAR_1279 NC_010612.1 1561284 1562870 R causes DNA methylation; DNA methylase complement(1561284..1562870) Mycobacterium marinum M 6225534 YP_001849593.1 CDS fbiB NC_010612.1 1562899 1564263 R catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase complement(1562899..1564263) Mycobacterium marinum M 6225535 YP_001849594.1 CDS fbiA NC_010612.1 1564260 1565249 R catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase complement(1564260..1565249) Mycobacterium marinum M 6225536 YP_001849595.1 CDS whiB2 NC_010612.1 1565642 1566025 D involved in transcriptional mechanism; transcriptional regulatory protein Whib-like WhiB2 1565642..1566025 Mycobacterium marinum M 6225537 YP_001849596.1 CDS MMAR_1283 NC_010612.1 1566091 1566621 R hypothetical protein complement(1566091..1566621) Mycobacterium marinum M 6225538 YP_001849597.1 CDS MMAR_1284 NC_010612.1 1566636 1567133 D hypothetical protein 1566636..1567133 Mycobacterium marinum M 6225539 YP_001849598.1 CDS manB NC_010612.1 1567280 1568680 D converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 1567280..1568680 Mycobacterium marinum M 6225540 YP_001849599.1 CDS MMAR_1286 NC_010612.1 1568677 1569786 D hypothetical protein 1568677..1569786 Mycobacterium marinum M 6225541 YP_001849600.1 CDS manA NC_010612.1 1569794 1571020 D this enzyme converts D-mannose 6-phosphate to D- fructose 6-phosphate [catalytic activity: D-mannose 6- phosphate = D-fructose 6-phosphate]; mannose-6-phosphate isomerase ManA 1569794..1571020 Mycobacterium marinum M 6225542 YP_001849601.1 CDS MMAR_1288 NC_010612.1 1570998 1572419 R function unknown but contains dehydrogenase domain; hypothetical protein complement(1570998..1572419) Mycobacterium marinum M 6225543 YP_001849602.1 CDS MMAR_1289 NC_010612.1 1572450 1573844 R hypothetical protein complement(1572450..1573844) Mycobacterium marinum M 6225544 YP_001849603.1 CDS MMAR_1290 NC_010612.1 1573901 1575385 D thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane; cationic amino acid transport integral membrane protein 1573901..1575385 Mycobacterium marinum M 6225545 YP_001849604.1 CDS alkB NC_010612.1 1575496 1576746 D thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O]; transmembrane alkane 1-monooxygenase AlkB 1575496..1576746 Mycobacterium marinum M 6225546 YP_001849605.1 CDS rubA NC_010612.1 1576746 1576916 D involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase; rubredoxin RubA 1576746..1576916 Mycobacterium marinum M 6225547 YP_001849606.1 CDS rubB NC_010612.1 1576917 1577099 D involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase; rubredoxin RubB 1576917..1577099 Mycobacterium marinum M 6225548 YP_001849607.1 CDS MMAR_1294 NC_010612.1 1577096 1577746 D probably involved in a transcriptional mechanism; TetR family transcriptional regulator 1577096..1577746 Mycobacterium marinum M 6225549 YP_001849608.1 CDS sahH NC_010612.1 1577851 1579329 D catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 1577851..1579329 Mycobacterium marinum M 6225550 YP_001849609.1 CDS MMAR_1296 NC_010612.1 1579673 1580272 D PE-PGRS family protein 1579673..1580272 Mycobacterium marinum M 6225551 YP_001849610.1 CDS MMAR_1297 NC_010612.1 1580673 1582757 D PPE family protein 1580673..1582757 Mycobacterium marinum M 6225552 YP_001849611.1 CDS tmk NC_010612.1 1582821 1583474 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1582821..1583474 Mycobacterium marinum M 6225553 YP_001849612.1 CDS mtrA NC_010612.1 1583554 1584231 D transcriptional activator part of a two-component regulatory system; two-component sensory transduction transcriptional regulatory protein MtrA 1583554..1584231 Mycobacterium marinum M 6225554 YP_001849613.1 CDS mtrB NC_010612.1 1584281 1585960 D sensor part of a two-component regulatory system; two-component sensory transduction histidine kinase MtrB 1584281..1585960 Mycobacterium marinum M 6225555 YP_001849614.1 CDS lpqB NC_010612.1 1585960 1587738 D lipoprotein LpqB 1585960..1587738 Mycobacterium marinum M 6225556 YP_001849615.1 CDS MMAR_1302 NC_010612.1 1587799 1588629 D hypothetical protein 1587799..1588629 Mycobacterium marinum M 6225557 YP_001849616.1 CDS MMAR_1303 NC_010612.1 1588672 1589307 D function unknown, but contains amidophosphoribosyltransferase domain; hypothetical protein 1588672..1589307 Mycobacterium marinum M 6225558 YP_001849617.1 CDS MMAR_1304 NC_010612.1 1589649 1590338 D function unknown but has domain identity with sigma 54 modulation protein; hypothetical protein 1589649..1590338 Mycobacterium marinum M 6225559 YP_001849618.1 CDS secA1 NC_010612.1 1590435 1593287 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1590435..1593287 Mycobacterium marinum M 6225560 YP_001849619.1 CDS MMAR_1306 NC_010612.1 1593372 1596602 D function unknown, but seems involved in efflux system (probably sugar or drug transport); transmembrane transport protein 1593372..1596602 Mycobacterium marinum M 6225561 YP_001849620.1 CDS MMAR_1307 NC_010612.1 1596659 1597414 D hypothetical protein 1596659..1597414 Mycobacterium marinum M 6225562 YP_001849621.1 CDS MMAR_1308 NC_010612.1 1597486 1597968 D function unknown but has a putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [inorganic ion transport and metabolism]; hypothetical protein 1597486..1597968 Mycobacterium marinum M 6225563 YP_001849622.1 CDS MMAR_1309 NC_010612.1 1597973 1599118 D probably involved in transport of undeterminated substrate (possibly cations Na/H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane; membrane transporter 1597973..1599118 Mycobacterium marinum M 6225564 YP_001849623.1 CDS MMAR_1310 NC_010612.1 1599136 1599774 R hypothetical protein complement(1599136..1599774) Mycobacterium marinum M 6225565 YP_001849624.1 CDS MMAR_1311 NC_010612.1 1599882 1601300 D hypothetical protein 1599882..1601300 Mycobacterium marinum M 6225566 YP_001849625.1 CDS pvdS NC_010612.1 1601343 1602215 D possibly involved in transcriptional mechanism (probably sigma factor promoting attachment of the RNA polymerase to specific initiation sites); transcriptional regulatory protein PvdS 1601343..1602215 Mycobacterium marinum M 6225567 YP_001849626.1 CDS MMAR_1313 NC_010612.1 1602281 1602781 D hypothetical protein 1602281..1602781 Mycobacterium marinum M 6225568 YP_001849627.1 CDS MMAR_1314 NC_010612.1 1602922 1604076 D function unknown, probably involved in cellular metabolism; oxidoreductase 1602922..1604076 Mycobacterium marinum M 6225569 YP_001849628.1 CDS desA3 NC_010612.1 1604165 1605451 D thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3 1604165..1605451 Mycobacterium marinum M 6225570 YP_001849629.1 CDS desA3_1 NC_010612.1 1605681 1606967 D thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3 1605681..1606967 Mycobacterium marinum M 6225571 YP_001849630.1 CDS fadA6_4 NC_010612.1 1607005 1608186 R function unknown, but involved in lipid metabolism [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]; acetyl-CoA acetyltransferase FadA6_4 complement(1607005..1608186) Mycobacterium marinum M 6225572 YP_001849631.1 CDS MMAR_1318 NC_010612.1 1608281 1608748 D function unknown. could be involved in regulatory mechanism; transcriptional regulatory protein 1608281..1608748 Mycobacterium marinum M 6225573 YP_001849632.1 CDS MMAR_1319 NC_010612.1 1608735 1609727 R hypothetical protein complement(1608735..1609727) Mycobacterium marinum M 6225574 YP_001849633.1 CDS aroA NC_010612.1 1609724 1611019 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1609724..1611019) Mycobacterium marinum M 6225575 YP_001849634.1 CDS MMAR_1321 NC_010612.1 1611065 1611847 D hypothetical protein 1611065..1611847 Mycobacterium marinum M 6225576 YP_001849635.1 CDS fadB3 NC_010612.1 1611945 1612829 D thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle [catalytic activity: (S)-3- hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH]; 3-hydroxybutyryl-CoA dehydrogenase FadB3 1611945..1612829 Mycobacterium marinum M 6225577 YP_001849636.1 CDS MMAR_1323 NC_010612.1 1612894 1614174 D hypothetical protein 1612894..1614174 Mycobacterium marinum M 6225578 YP_001849637.1 CDS MMAR_5565 NC_010612.1 1614279 1614602 D hypothetical protein 1614279..1614602 Mycobacterium marinum M 6225579 YP_001849638.1 CDS MMAR_1324 NC_010612.1 1614985 1617714 D may be involved in regulation; hypothetical protein 1614985..1617714 Mycobacterium marinum M 6225580 YP_001849639.1 CDS MMAR_1325 NC_010612.1 1618502 1619800 D hypothetical protein 1618502..1619800 Mycobacterium marinum M 6225581 YP_001849640.1 CDS MMAR_1326 NC_010612.1 1619876 1620190 D hypothetical protein 1619876..1620190 Mycobacterium marinum M 6225582 YP_001849641.1 CDS MMAR_1327 NC_010612.1 1620215 1620886 D hypothetical protein 1620215..1620886 Mycobacterium marinum M 6225583 YP_001849642.1 CDS MMAR_1328 NC_010612.1 1621109 1621705 D hypothetical protein 1621109..1621705 Mycobacterium marinum M 6225584 YP_001849643.1 CDS MMAR_1329 NC_010612.1 1621784 1623304 D hypothetical protein 1621784..1623304 Mycobacterium marinum M 6225585 YP_001849644.1 CDS MMAR_1330 NC_010612.1 1623301 1623648 D hypothetical protein 1623301..1623648 Mycobacterium marinum M 6225586 YP_001849645.1 CDS MMAR_1331 NC_010612.1 1623819 1625951 D hypothetical protein 1623819..1625951 Mycobacterium marinum M 6225587 YP_001849646.1 CDS MMAR_1332 NC_010612.1 1625977 1626432 R hypothetical protein complement(1625977..1626432) Mycobacterium marinum M 6225588 YP_001849647.1 CDS MMAR_1333 NC_010612.1 1626444 1627292 R function unknown, probably involved in cellular metabolism; short chain dehydrogenase complement(1626444..1627292) Mycobacterium marinum M 6225589 YP_001849648.1 CDS sigH NC_010612.1 1627492 1628259 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 1627492..1628259 Mycobacterium marinum M 6225590 YP_001849649.1 CDS MMAR_1335 NC_010612.1 1628256 1628561 D binds sigma factor and inhibits it. probably involved in survival following heat shock and oxidative stress; anti-sigma factor 1628256..1628561 Mycobacterium marinum M 6225591 YP_001849650.1 CDS MMAR_1336 NC_010612.1 1628923 1629138 D putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1628923..1629138 Mycobacterium marinum M 6225592 YP_001849651.1 CDS MMAR_1337 NC_010612.1 1629188 1630687 D sensor part of a two-component regulatory system; sensor kinase from two-component regulatory system 1629188..1630687 Mycobacterium marinum M 6225593 YP_001849652.1 CDS whiB1 NC_010612.1 1630750 1631004 R involved in transcriptional mechanism; transcriptional regulatory protein Whib-like WhiB1 complement(1630750..1631004) Mycobacterium marinum M 6225594 YP_001849653.1 CDS MMAR_1339 NC_010612.1 1631288 1632253 R hypothetical protein complement(1631288..1632253) Mycobacterium marinum M 6225595 YP_001849654.1 CDS MMAR_1340 NC_010612.1 1632378 1632809 D hypothetical protein 1632378..1632809 Mycobacterium marinum M 6225596 YP_001849655.1 CDS MMAR_1341 NC_010612.1 1632761 1633243 R function unknown, involved in cellular metabolism; acetyltransferase complement(1632761..1633243) Mycobacterium marinum M 6225597 YP_001849656.1 CDS entC NC_010612.1 1633240 1634340 R could be involved in enterobactin biosynthesis. enterobactin is an iron-chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm. could be also involved in 2,3- dihydroxybenzoate or enterochelin or menaquinone biosynthesis [catalytic activity: chorismate = isochorismate]; isochorismate synthase EntC complement(1633240..1634340) Mycobacterium marinum M 6225598 YP_001849657.1 CDS gpm2 NC_010612.1 1634337 1634972 R forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase complement(1634337..1634972) Mycobacterium marinum M 6225599 YP_001849658.1 CDS MMAR_1344 NC_010612.1 1635013 1635813 D possibly involved in control of chromosome partitioning; Soj/ParA-related protein 1635013..1635813 Mycobacterium marinum M 6225600 YP_001849659.1 CDS MMAR_1345 NC_010612.1 1635836 1637050 R hypothetical protein complement(1635836..1637050) Mycobacterium marinum M 6225601 YP_001849660.1 CDS rhlE NC_010612.1 1637065 1638618 R has a helix-destabilizing activity; ATP-dependent RNA helicase RhlE complement(1637065..1638618) Mycobacterium marinum M 6225602 YP_001849661.1 CDS MMAR_1347 NC_010612.1 1638881 1639576 D hypothetical protein 1638881..1639576 Mycobacterium marinum M 6225603 YP_001849662.1 CDS MMAR_1348 NC_010612.1 1639589 1640569 R putative threonine and proline rich protein complement(1639589..1640569) Mycobacterium marinum M 6225604 YP_001849663.1 CDS MMAR_1349 NC_010612.1 1640584 1640829 D hypothetical protein 1640584..1640829 Mycobacterium marinum M 6225605 YP_001849664.1 CDS MMAR_1350 NC_010612.1 1640826 1641509 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(1640826..1641509) Mycobacterium marinum M 6225606 YP_001849665.1 CDS MMAR_1351 NC_010612.1 1641695 1642720 D hypothetical protein 1641695..1642720 Mycobacterium marinum M 6225607 YP_001849666.1 CDS moeB1 NC_010612.1 1642892 1644073 D The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 1642892..1644073 Mycobacterium marinum M 6225608 YP_001849667.1 CDS MMAR_1353 NC_010612.1 1644139 1644993 D hypothetical protein 1644139..1644993 Mycobacterium marinum M 6225609 YP_001849668.1 CDS MMAR_1354 NC_010612.1 1644990 1645298 R causes methylation of DNA; DNA-methyltransferase (modification methylase) complement(1644990..1645298) Mycobacterium marinum M 6225610 YP_001849669.1 CDS lipV NC_010612.1 1645301 1646086 R function unknown, presumed lipolytic enzyme involved in cellular metabolism; lipase LipV complement(1645301..1646086) Mycobacterium marinum M 6225611 YP_001849670.1 CDS MMAR_1356 NC_010612.1 1646151 1646372 R hypothetical protein complement(1646151..1646372) Mycobacterium marinum M 6225612 YP_001849671.1 CDS MMAR_1357 NC_010612.1 1646542 1647384 D hypothetical protein 1646542..1647384 Mycobacterium marinum M 6225613 YP_001849672.1 CDS MMAR_1358 NC_010612.1 1647530 1650703 D has both ATPase and helicase activities; ATP-dependent DNA helicase 1647530..1650703 Mycobacterium marinum M 6225614 YP_001849673.1 CDS MMAR_1359 NC_010612.1 1650700 1654005 D has both ATPase and helicase activities; ATP-dependent DNA helicase 1650700..1654005 Mycobacterium marinum M 6225615 YP_001849674.1 CDS MMAR_1360 NC_010612.1 1654067 1655137 D thought to be involved in cation transport across the membrane; transmembrane cation transporter 1654067..1655137 Mycobacterium marinum M 6225616 YP_001849675.1 CDS nudC NC_010612.1 1655303 1656229 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 1655303..1656229 Mycobacterium marinum M 6225617 YP_001849676.1 CDS lpqQ NC_010612.1 1656233 1656958 R lipoprotein LpqQ complement(1656233..1656958) Mycobacterium marinum M 6225618 YP_001849677.1 CDS MMAR_1363 NC_010612.1 1657143 1657397 R glutaredoxin protein complement(1657143..1657397) Mycobacterium marinum M 6225619 YP_001849678.1 CDS uvrD2 NC_010612.1 1657523 1659652 D involved in nucleotide excision repair. has both ATPase and helicase activities. unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single- stranded region is present. involved in the postincision events of nucleotide excision repair and methyl-directed mismatch repair; ATP-dependent DNA helicase II UvrD2 1657523..1659652 Mycobacterium marinum M 6225620 YP_001849679.1 CDS whiB7 NC_010612.1 1660071 1660346 D involved in transcriptional mechanism; transcriptional regulatory protein Whib-like WhiB7 1660071..1660346 Mycobacterium marinum M 6225621 YP_001849680.1 CDS MMAR_1366 NC_010612.1 1660449 1661792 R thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system; ABC transporter ATP-binding protein complement(1660449..1661792) Mycobacterium marinum M 6225622 YP_001849681.1 CDS MMAR_1367 NC_010612.1 1661984 1662157 D hypothetical protein 1661984..1662157 Mycobacterium marinum M 6225623 YP_001849682.1 CDS MMAR_1368 NC_010612.1 1662177 1663016 R hypothetical protein complement(1662177..1663016) Mycobacterium marinum M 6225624 YP_001849683.1 CDS MMAR_1369 NC_010612.1 1663055 1664473 R hypothetical protein complement(1663055..1664473) Mycobacterium marinum M 6225625 YP_001849684.1 CDS MMAR_1370 NC_010612.1 1664552 1665574 D serine protease 1664552..1665574 Mycobacterium marinum M 6225626 YP_001849685.1 CDS MMAR_1371 NC_010612.1 1665696 1668683 D hypothetical protein 1665696..1668683 Mycobacterium marinum M 6225627 YP_001849686.1 CDS MMAR_1372 NC_010612.1 1668828 1669841 R hypothetical protein complement(1668828..1669841) Mycobacterium marinum M 6225628 YP_001849687.1 CDS MMAR_1373 NC_010612.1 1670408 1671964 D transposition of ISMyma05; transposase for ISMyma05 1670408..1671964 Mycobacterium marinum M 6225630 YP_001849688.1 CDS MMAR_1374 NC_010612.1 1672268 1672642 D function unknown, possible role in posttranslational modification, protein turnover, chaperonefunctions; FK-506 binding protein, peptidyl-prolyl cis- trans isomerase 1672268..1672642 Mycobacterium marinum M 6225631 YP_001849689.1 CDS atsD_1 NC_010612.1 1672942 1675245 D thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase AtsD 1672942..1675245 Mycobacterium marinum M 6225632 YP_001849690.1 CDS MMAR_1376 NC_010612.1 1675358 1675813 D hypothetical protein 1675358..1675813 Mycobacterium marinum M 6225633 YP_001849691.1 CDS MMAR_1377 NC_010612.1 1675810 1676742 D hypothetical protein 1675810..1676742 Mycobacterium marinum M 6225634 YP_001849692.1 CDS MMAR_1378 NC_010612.1 1676793 1678214 R involved in transcriptional mechanism; transcriptional regulatory protein complement(1676793..1678214) Mycobacterium marinum M 6225635 YP_001849693.1 CDS MMAR_1379 NC_010612.1 1678334 1679839 D hypothetical protein 1678334..1679839 Mycobacterium marinum M 6225636 YP_001849694.1 CDS MMAR_1380 NC_010612.1 1679839 1680756 D methylisocitrate lyase 2 1679839..1680756 Mycobacterium marinum M 6225637 YP_001849695.1 CDS gltA1 NC_010612.1 1680753 1681886 D catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 1680753..1681886 Mycobacterium marinum M 6225638 YP_001849696.1 CDS MMAR_1382 NC_010612.1 1682286 1682765 D hypothetical protein 1682286..1682765 Mycobacterium marinum M 6225639 YP_001849697.1 CDS MMAR_1383 NC_010612.1 1682865 1683128 D hypothetical protein 1682865..1683128 Mycobacterium marinum M 6225640 YP_001849698.1 CDS MMAR_1384 NC_010612.1 1683199 1683933 D hypothetical protein 1683199..1683933 Mycobacterium marinum M 6225641 YP_001849699.1 CDS MMAR_1385 NC_010612.1 1683982 1684359 D hypothetical protein 1683982..1684359 Mycobacterium marinum M 6225642 YP_001849700.1 CDS MMAR_1386 NC_010612.1 1684429 1684833 D hypothetical protein 1684429..1684833 Mycobacterium marinum M 6225643 YP_001849701.1 CDS MMAR_1387 NC_010612.1 1684844 1686235 R possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]; monoamine oxidase complement(1684844..1686235) Mycobacterium marinum M 6225644 YP_001849702.1 CDS hpx NC_010612.1 1686396 1687376 D supposed involved in detoxification reactions; non-heme haloperoxidase Hpx 1686396..1687376 Mycobacterium marinum M 6225645 YP_001849703.1 CDS aofH NC_010612.1 1687371 1688717 R may catalyze the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]. may have important function in metabolism. supposed involved; flavin-containing monoamine oxidase AofH complement(1687371..1688717) Mycobacterium marinum M 6225646 YP_001849704.1 CDS MMAR_1390 NC_010612.1 1688821 1689819 D function unknown, probably involved in cellular metabolism; oxidoreductase 1688821..1689819 Mycobacterium marinum M 6225647 YP_001849705.1 CDS MMAR_1391 NC_010612.1 1689881 1692475 R PE-PGRS family protein complement(1689881..1692475) Mycobacterium marinum M 6225648 YP_001849706.1 CDS MMAR_1392 NC_010612.1 1692629 1693753 R hypothetical protein complement(1692629..1693753) Mycobacterium marinum M 6225649 YP_001849707.1 CDS MMAR_1393 NC_010612.1 1693753 1694889 R hypothetical protein complement(1693753..1694889) Mycobacterium marinum M 6225650 YP_001849708.1 CDS MMAR_1394 NC_010612.1 1694934 1695536 D involved in transcriptional mechanism; TetR family transcriptional regulator 1694934..1695536 Mycobacterium marinum M 6225651 YP_001849709.1 CDS MMAR_1395 NC_010612.1 1695533 1696399 D function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 1695533..1696399 Mycobacterium marinum M 6225652 YP_001849710.1 CDS MMAR_1396 NC_010612.1 1696562 1697959 R transposition of ISMyma02; transposase for insertion sequence ISMyma02 complement(1696562..1697959) Mycobacterium marinum M 6225653 YP_001849711.1 CDS MMAR_1397 NC_010612.1 1698199 1699179 D hypothetical protein 1698199..1699179 Mycobacterium marinum M 6225654 YP_001849712.1 CDS MMAR_1398 NC_010612.1 1699176 1699658 D hypothetical protein 1699176..1699658 Mycobacterium marinum M 6225655 YP_001849713.1 CDS moxR3 NC_010612.1 1699707 1700675 D involved in transcriptional mechanism; regulates methanol dehydrogenase; methanol dehydrogenase transcriptional regulatory protein MoxR3 1699707..1700675 Mycobacterium marinum M 6225656 YP_001849714.1 CDS MMAR_1400 NC_010612.1 1700689 1701966 D hypothetical protein 1700689..1701966 Mycobacterium marinum M 6225657 YP_001849715.1 CDS MMAR_1401 NC_010612.1 1701968 1702417 D hypothetical protein 1701968..1702417 Mycobacterium marinum M 6225658 YP_001849716.1 CDS MMAR_1402 NC_010612.1 1702638 1704536 D PPE family protein 1702638..1704536 Mycobacterium marinum M 6225659 YP_001849717.1 CDS MMAR_1403 NC_010612.1 1704699 1706096 R transposition of ISMyma02; transposase for insertion sequence ISMyma02 complement(1704699..1706096) Mycobacterium marinum M 6225660 YP_001849718.1 CDS MMAR_1404 NC_010612.1 1706265 1706870 D phage excisionase 1706265..1706870 Mycobacterium marinum M 6225661 YP_001849719.1 CDS MMAR_1405 NC_010612.1 1707278 1709542 R hypothetical protein complement(1707278..1709542) Mycobacterium marinum M 6225662 YP_001849720.1 CDS MMAR_1406 NC_010612.1 1709558 1710190 R hypothetical protein complement(1709558..1710190) Mycobacterium marinum M 6225663 YP_001849721.1 CDS MMAR_1407 NC_010612.1 1710411 1711808 D transposition of ISMyma02; transposase for insertion sequence ISMyma02 1710411..1711808 Mycobacterium marinum M 6225664 YP_001849722.1 CDS MMAR_5541 NC_010612.1 1712688 1713011 D transposition of ISMyma03; transposase, ISMyma03_aa1 1712688..1713011 Mycobacterium marinum M 6225665 YP_001849723.1 CDS MMAR_1408 NC_010612.1 1713098 1713961 D transposition of ISMyma03; transposase, ISMyma03_aa2 1713098..1713961 Mycobacterium marinum M 6225666 YP_001849724.1 CDS MMAR_1409 NC_010612.1 1714422 1715423 R hypothetical protein complement(1714422..1715423) Mycobacterium marinum M 6225667 YP_001849725.1 CDS MMAR_1410 NC_010612.1 1715747 1716247 D hypothetical protein 1715747..1716247 Mycobacterium marinum M 6225668 YP_001849726.1 CDS MMAR_1411 NC_010612.1 1716366 1718303 D hypothetical protein 1716366..1718303 Mycobacterium marinum M 6225669 YP_001849727.1 CDS MMAR_1412 NC_010612.1 1718685 1718933 R hypothetical protein complement(1718685..1718933) Mycobacterium marinum M 6225670 YP_001849728.1 CDS MMAR_1413 NC_010612.1 1719456 1720061 R putative transcriptional regulatory protein complement(1719456..1720061) Mycobacterium marinum M 6225671 YP_001849729.1 CDS cyaA_1 NC_010612.1 1720082 1720810 D possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; adenylate cyclase CyaA 1720082..1720810 Mycobacterium marinum M 6225672 YP_001849730.1 CDS MMAR_1415 NC_010612.1 1720827 1721420 D function unknown. contains a SAM-dependent methyltransferase domain; hypothetical protein 1720827..1721420 Mycobacterium marinum M 6225673 YP_001849731.1 CDS MMAR_1418 NC_010612.1 1722137 1723720 D PPE family protein 1722137..1723720 Mycobacterium marinum M 6225674 YP_001849732.1 CDS MMAR_1419 NC_010612.1 1724188 1724814 R hypothetical protein complement(1724188..1724814) Mycobacterium marinum M 6225675 YP_001849733.1 CDS cynT NC_010612.1 1725443 1726279 R function unknown; domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide; carbonic anhydrase, CynT complement(1725443..1726279) Mycobacterium marinum M 6225676 YP_001849734.1 CDS MMAR_1421 NC_010612.1 1726843 1727103 R Single copy element; transposase for insertion sequence complement(1726843..1727103) Mycobacterium marinum M 6225677 YP_001849735.1 CDS MMAR_1422 NC_010612.1 1727691 1727960 R hypothetical protein complement(1727691..1727960) Mycobacterium marinum M 6225678 YP_001849736.1 CDS MMAR_1423 NC_010612.1 1727983 1729908 R involved in signal transduction (via phosphorylation). catalytic activity: ATP + a protein = ADP + a phosphoprotein]; anchored-membrane serine/threonine-protein kinase complement(1727983..1729908) Mycobacterium marinum M 6225679 YP_001849737.1 CDS MMAR_1424 NC_010612.1 1730132 1730266 R hypothetical protein complement(1730132..1730266) Mycobacterium marinum M 6225680 YP_001849738.1 CDS MMAR_1425 NC_010612.1 1730263 1730451 R single copy element; transposase for insertion sequence complement(1730263..1730451) Mycobacterium marinum M 6225681 YP_001849739.1 CDS MMAR_1426 NC_010612.1 1730701 1731111 R hypothetical protein complement(1730701..1731111) Mycobacterium marinum M 6225682 YP_001849740.1 CDS MMAR_1427 NC_010612.1 1731589 1731864 D hypothetical protein 1731589..1731864 Mycobacterium marinum M 6225683 YP_001849741.1 CDS MMAR_1428 NC_010612.1 1732032 1732403 D hypothetical protein 1732032..1732403 Mycobacterium marinum M 6225684 YP_001849742.1 CDS MMAR_1429 NC_010612.1 1732539 1732916 D function unknown, contains a N-term cation transport ATPase domain; hypothetical protein 1732539..1732916 Mycobacterium marinum M 6225685 YP_001849743.1 CDS MMAR_1430 NC_010612.1 1733014 1733310 D hypothetical protein 1733014..1733310 Mycobacterium marinum M 6225686 YP_001849744.1 CDS zntA NC_010612.1 1733300 1735738 D metal cation-transporting ATPase; possibly catalyzes the transport of zinc with hydrolysis of ATP [catalytic activity: ATP + H(2)O + zinc (in) = ADP + phosphate + zinc (out)]; cation transport ATPase, ZntA 1733300..1735738 Mycobacterium marinum M 6225687 YP_001849745.1 CDS MMAR_1432 NC_010612.1 1735803 1736435 D hypothetical protein 1735803..1736435 Mycobacterium marinum M 6225688 YP_001849746.1 CDS MMAR_1433 NC_010612.1 1736726 1737805 D domain identity with XerD and XerC integrases, DNA breaking-rejoining enzymes, n- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance; site-specific integrase 1736726..1737805 Mycobacterium marinum M 6225689 YP_001849747.1 CDS MMAR_1438 NC_010612.1 1742483 1744687 D hypothetical protein 1742483..1744687 Mycobacterium marinum M 6225693 YP_001849748.1 CDS MMAR_1439 NC_010612.1 1744684 1745142 D hypothetical protein 1744684..1745142 Mycobacterium marinum M 6225694 YP_001849749.1 CDS MMAR_1440 NC_010612.1 1745104 1746210 R Single copy element. there are 24 copies of this element in M. smegmatis MC2155; ISL3 family transposase complement(1745104..1746210) Mycobacterium marinum M 6225695 YP_001849750.1 CDS MMAR_1441 NC_010612.1 1746393 1746794 R hypothetical protein complement(1746393..1746794) Mycobacterium marinum M 6225696 YP_001849751.1 CDS MMAR_1442 NC_010612.1 1746835 1751286 R PE-PGRS family protein complement(1746835..1751286) Mycobacterium marinum M 6225697 YP_001849752.1 CDS MMAR_1443 NC_010612.1 1751533 1752945 R high domain identity with a protein kinase; hypothetical protein complement(1751533..1752945) Mycobacterium marinum M 6225698 YP_001849753.1 CDS MMAR_1444 NC_010612.1 1753034 1753636 D involved in transcriptional mechanism; TetR family transcriptional regulator 1753034..1753636 Mycobacterium marinum M 6225699 YP_001849754.1 CDS MMAR_1445 NC_010612.1 1753983 1755380 D transposition of insertion sequence ISMyma02; transposase for insertion sequence ISMyma02 1753983..1755380 Mycobacterium marinum M 6225700 YP_001849755.1 CDS MMAR_1447 NC_010612.1 1756135 1756425 R hypothetical protein complement(1756135..1756425) Mycobacterium marinum M 6225701 YP_001849756.1 CDS MMAR_1448 NC_010612.1 1756710 1759259 R metal cation-transporting ATPase; possibly catalyzes the transport of zinc metal cations with hydrolysis of ATP [catalytic activity: ATP + H(2)O + zinc metal cations (in) = ADP + phosphate + zinc metal cations (out)]; zinc cation transport ATPase complement(1756710..1759259) Mycobacterium marinum M 6225702 YP_001849757.1 CDS MMAR_1449 NC_010612.1 1760219 1761469 D function unknown; PPE family protein 1760219..1761469 Mycobacterium marinum M 6225703 YP_001849758.1 CDS MMAR_1450 NC_010612.1 1761658 1761885 R hypothetical protein complement(1761658..1761885) Mycobacterium marinum M 6225704 YP_001849759.1 CDS MMAR_5540 NC_010612.1 1762950 1764155 R transposition of ISMyma02; transposase for insertion sequence ISMyma02 complement(1762950..1764155) Mycobacterium marinum M 6225706 YP_001849760.1 CDS MMAR_1452 NC_010612.1 1764630 1765424 R transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 complement(1764630..1765424) Mycobacterium marinum M 6225708 YP_001849761.1 CDS MMAR_1453 NC_010612.1 1765466 1765747 R transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 complement(1765466..1765747) Mycobacterium marinum M 6225709 YP_001849762.1 CDS MMAR_1454 NC_010612.1 1766091 1766363 R hypothetical protein complement(1766091..1766363) Mycobacterium marinum M 6225710 YP_001849763.1 CDS MMAR_1455 NC_010612.1 1766409 1767272 R transposition of ISMyma03; transposase, ISMyma03_aa2 complement(1766409..1767272) Mycobacterium marinum M 6225711 YP_001849764.1 CDS MMAR_1456 NC_010612.1 1767359 1767682 R transposition of ISMyma03; transposase, ISMyma03_aa1 complement(1767359..1767682) Mycobacterium marinum M 6225712 YP_001849765.1 CDS MMAR_1457 NC_010612.1 1767760 1767990 R hypothetical protein complement(1767760..1767990) Mycobacterium marinum M 6225713 YP_001849766.1 CDS MMAR_1458 NC_010612.1 1768000 1768362 R hypothetical protein complement(1768000..1768362) Mycobacterium marinum M 6225714 YP_001849767.1 CDS MMAR_1459 NC_010612.1 1768607 1769002 R hypothetical protein complement(1768607..1769002) Mycobacterium marinum M 6225715 YP_001849768.1 CDS MMAR_1460 NC_010612.1 1769131 1770540 R PPE family protein complement(1769131..1770540) Mycobacterium marinum M 6225716 YP_001849769.1 CDS MMAR_1461 NC_010612.1 1770620 1771903 R PPE family protein complement(1770620..1771903) Mycobacterium marinum M 6225717 YP_001849770.1 CDS MMAR_1462 NC_010612.1 1772056 1773156 R oxidoreductase complement(1772056..1773156) Mycobacterium marinum M 6225718 YP_001849771.1 CDS MMAR_1464 NC_010612.1 1773520 1773939 R hypothetical protein complement(1773520..1773939) Mycobacterium marinum M 6225719 YP_001849772.1 CDS MMAR_1465 NC_010612.1 1774244 1774648 D hypothetical protein 1774244..1774648 Mycobacterium marinum M 6225720 YP_001849773.1 CDS MMAR_1466 NC_010612.1 1774896 1775843 R Single copy element; transposition of an insertion sequence; transposase complement(1774896..1775843) Mycobacterium marinum M 6225721 YP_001849774.1 CDS MMAR_1468 NC_010612.1 1777194 1778591 R transposition of the insertion sequence ISMyma02; transposase for insertion sequence ISMyma02 complement(1777194..1778591) Mycobacterium marinum M 6225723 YP_001849775.1 CDS MMAR_1469 NC_010612.1 1779568 1781451 D PPE family protein 1779568..1781451 Mycobacterium marinum M 6225724 YP_001849776.1 CDS nuoN NC_010612.1 1781510 1783096 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(1781510..1783096) Mycobacterium marinum M 6225725 YP_001849777.1 CDS nuoM NC_010612.1 1783093 1784679 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(1783093..1784679) Mycobacterium marinum M 6225726 YP_001849778.1 CDS nuoL NC_010612.1 1784676 1786577 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(1784676..1786577) Mycobacterium marinum M 6225727 YP_001849779.1 CDS nuoK NC_010612.1 1786588 1786887 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(1786588..1786887) Mycobacterium marinum M 6225728 YP_001849780.1 CDS nuoJ NC_010612.1 1786884 1787672 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(1786884..1787672) Mycobacterium marinum M 6225729 YP_001849781.1 CDS nuoI NC_010612.1 1787669 1788214 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(1787669..1788214) Mycobacterium marinum M 6225730 YP_001849782.1 CDS nuoH NC_010612.1 1788207 1789481 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(1788207..1789481) Mycobacterium marinum M 6225731 YP_001849783.1 CDS nuoG NC_010612.1 1789531 1791948 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(1789531..1791948) Mycobacterium marinum M 6225732 YP_001849784.1 CDS nuoF NC_010612.1 1791945 1793291 R involved in aerobic|anaerobic respiration [catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol]; NADH dehydrogenase I subunit F complement(1791945..1793291) Mycobacterium marinum M 6225733 YP_001849785.1 CDS nuoE NC_010612.1 1793291 1794046 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(1793291..1794046) Mycobacterium marinum M 6225734 YP_001849786.1 CDS nuoD NC_010612.1 1794043 1795341 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D complement(1794043..1795341) Mycobacterium marinum M 6225735 YP_001849787.1 CDS nuoC NC_010612.1 1795361 1796077 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C complement(1795361..1796077) Mycobacterium marinum M 6225736 YP_001849788.1 CDS nuoB NC_010612.1 1796074 1796628 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(1796074..1796628) Mycobacterium marinum M 6225737 YP_001849789.1 CDS nuoA NC_010612.1 1796637 1797125 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(1796637..1797125) Mycobacterium marinum M 6225738 YP_001849790.1 CDS MMAR_1484 NC_010612.1 1797440 1798780 D PPE family protein 1797440..1798780 Mycobacterium marinum M 6225739 YP_001849791.1 CDS plcB_2 NC_010612.1 1798962 1800548 D hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 1798962..1800548 Mycobacterium marinum M 6225740 YP_001849792.1 CDS MMAR_1486 NC_010612.1 1800585 1801034 R two-component system response regulator complement(1800585..1801034) Mycobacterium marinum M 6225741 YP_001849793.1 CDS MMAR_1487 NC_010612.1 1801061 1801600 R hypothetical protein complement(1801061..1801600) Mycobacterium marinum M 6225742 YP_001849794.1 CDS MMAR_1488 NC_010612.1 1801636 1802046 R hypothetical protein complement(1801636..1802046) Mycobacterium marinum M 6225743 YP_001849795.1 CDS MMAR_1489 NC_010612.1 1802058 1802399 R hypothetical protein complement(1802058..1802399) Mycobacterium marinum M 6225744 YP_001849796.1 CDS MMAR_1490 NC_010612.1 1802399 1803361 R hypothetical protein complement(1802399..1803361) Mycobacterium marinum M 6225745 YP_001849797.1 CDS fadE12_3 NC_010612.1 1803358 1804596 R involved in lipid degradation; acyl-CoA dehydrogenase FadE12 complement(1803358..1804596) Mycobacterium marinum M 6225746 YP_001849798.1 CDS MMAR_1492 NC_010612.1 1804621 1805262 R involved in transcriptional mechanism; transcriptional regulatory protein complement(1804621..1805262) Mycobacterium marinum M 6225747 YP_001849799.1 CDS MMAR_1493 NC_010612.1 1805262 1806158 R hypothetical protein complement(1805262..1806158) Mycobacterium marinum M 6225748 YP_001849800.1 CDS MMAR_1494 NC_010612.1 1806155 1807360 R hypothetical protein complement(1806155..1807360) Mycobacterium marinum M 6225749 YP_001849801.1 CDS MMAR_1495 NC_010612.1 1807357 1808547 R hypothetical protein complement(1807357..1808547) Mycobacterium marinum M 6225750 YP_001849802.1 CDS MMAR_1496 NC_010612.1 1808550 1809653 R oxidoreductase complement(1808550..1809653) Mycobacterium marinum M 6225751 YP_001849803.1 CDS MMAR_1497 NC_010612.1 1809969 1811951 D PPE family protein 1809969..1811951 Mycobacterium marinum M 6225752 YP_001849804.1 CDS fadB4 NC_010612.1 1811969 1812940 R involved in lipid degradation [catalytic activity: NADPH + quinone = NADP(+) + semiquinone]; NADPH quinone oxidoreductase FadB4 complement(1811969..1812940) Mycobacterium marinum M 6225753 YP_001849805.1 CDS MMAR_1499 NC_010612.1 1812983 1813981 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(1812983..1813981) Mycobacterium marinum M 6225754 YP_001849806.1 CDS MMAR_1500 NC_010612.1 1814049 1815083 R hypothetical protein complement(1814049..1815083) Mycobacterium marinum M 6225755 YP_001849807.1 CDS MMAR_1501 NC_010612.1 1815053 1816093 R function unknown, C-term identity with glyoxalase domains; hypothetical protein complement(1815053..1816093) Mycobacterium marinum M 6225756 YP_001849808.1 CDS MMAR_1502 NC_010612.1 1816090 1816953 R function unknown, N-term has esterase domain identity; hypothetical protein complement(1816090..1816953) Mycobacterium marinum M 6225757 YP_001849809.1 CDS MMAR_1503 NC_010612.1 1816950 1818563 R function unknown role in energy production/conversion; FAD-dependent oxidoreductase complement(1816950..1818563) Mycobacterium marinum M 6225758 YP_001849810.1 CDS MMAR_1504 NC_010612.1 1818671 1819339 D involved in transcriptional mechanism; transcriptional regulatory protein 1818671..1819339 Mycobacterium marinum M 6225759 YP_001849811.1 CDS mhpF NC_010612.1 1819336 1820346 D catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 1819336..1820346 Mycobacterium marinum M 6225760 YP_001849812.1 CDS MMAR_1506 NC_010612.1 1820343 1821377 D catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 1820343..1821377 Mycobacterium marinum M 6225761 YP_001849813.1 CDS MMAR_1507 NC_010612.1 1821426 1822202 D function unknown, possible role secondary metabolite biosynthesis; alpha-acetolactate decarboxylase 1821426..1822202 Mycobacterium marinum M 6225762 YP_001849814.1 CDS ilvB1_1 NC_010612.1 1822205 1823875 D catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; acetolactate synthase 1822205..1823875 Mycobacterium marinum M 6225763 YP_001849815.1 CDS fadE23 NC_010612.1 1823885 1825090 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE23 complement(1823885..1825090) Mycobacterium marinum M 6225764 YP_001849816.1 CDS fadE24 NC_010612.1 1825145 1826542 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE24 complement(1825145..1826542) Mycobacterium marinum M 6225765 YP_001849817.1 CDS MMAR_1511 NC_010612.1 1826624 1827412 R function unknown, involved in cellular metabolism; monophosphatase complement(1826624..1827412) Mycobacterium marinum M 6225766 YP_001849818.1 CDS MMAR_1512 NC_010612.1 1827436 1827771 D hypothetical protein 1827436..1827771 Mycobacterium marinum M 6225767 YP_001849819.1 CDS MMAR_1513 NC_010612.1 1827790 1828938 R PPE family protein complement(1827790..1828938) Mycobacterium marinum M 6225768 YP_001849820.1 CDS MMAR_1514 NC_010612.1 1829479 1830624 R PPE family protein complement(1829479..1830624) Mycobacterium marinum M 6225769 YP_001849821.1 CDS MMAR_1515 NC_010612.1 1831562 1832356 D may play a role in the adaptation to hypoxia, participating in the phosphorelay in the two-component regulatory system DevR/DevS; hypothetical protein 1831562..1832356 Mycobacterium marinum M 6225770 YP_001849822.1 CDS devR NC_010612.1 1832380 1833030 D regulator part of the two-component regulatory system DevR/DevS. controls HspX|Acr expression; two-component transcriptional regulatory protein DevR 1832380..1833030 Mycobacterium marinum M 6225771 YP_001849823.1 CDS devS NC_010612.1 1833042 1834799 D sensor part of the two-component regulatory system DevR/DevS. thought to control HspX|Acr expression; two-component sensor histidine kinase DevS 1833042..1834799 Mycobacterium marinum M 6225772 YP_001849824.1 CDS MMAR_1518 NC_010612.1 1834779 1835777 R hypothetical protein complement(1834779..1835777) Mycobacterium marinum M 6225773 YP_001849825.1 CDS MMAR_1519 NC_010612.1 1835969 1837357 D hypothetical protein 1835969..1837357 Mycobacterium marinum M 6225774 YP_001849826.1 CDS MMAR_1520 NC_010612.1 1837360 1837776 D hypothetical protein 1837360..1837776 Mycobacterium marinum M 6225775 YP_001849827.1 CDS MMAR_1521 NC_010612.1 1837858 1838286 R hypothetical protein complement(1837858..1838286) Mycobacterium marinum M 6225776 YP_001849828.1 CDS MMAR_1522 NC_010612.1 1838291 1839292 R hypothetical protein complement(1838291..1839292) Mycobacterium marinum M 6225777 YP_001849829.1 CDS MMAR_1523 NC_010612.1 1839444 1840817 D hypothetical protein 1839444..1840817 Mycobacterium marinum M 6225778 YP_001849830.1 CDS MMAR_1524 NC_010612.1 1840846 1841049 D hypothetical protein 1840846..1841049 Mycobacterium marinum M 6225779 YP_001849831.1 CDS agpS NC_010612.1 1841059 1842651 D involved in ether lipid biosynthesis [catalytic activity: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion]; alkyldihydroxyacetonephosphate synthase AgpS 1841059..1842651 Mycobacterium marinum M 6225780 YP_001849832.1 CDS fprA_1 NC_010612.1 1842652 1844022 R generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprA complement(1842652..1844022) Mycobacterium marinum M 6225781 YP_001849833.1 CDS prfB NC_010612.1 1844156 1845271 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 1844156..1845271 Mycobacterium marinum M 6225782 YP_001849834.1 CDS MMAR_1528 NC_010612.1 1845261 1846247 D function unknown but contains mechanosensitive (ms) ion channel forming domain with a possible role in cell envelope biogenesis; transmembrane protein 1845261..1846247 Mycobacterium marinum M 6225783 YP_001849835.1 CDS MMAR_1529 NC_010612.1 1846250 1846750 D function unknown: predicted solute binding protein; hypothetical protein 1846250..1846750 Mycobacterium marinum M 6225784 YP_001849836.1 CDS ftsE NC_010612.1 1846795 1847484 D involved in growth. thought to be involved in active transport of septation component across the membrane. responsible for energy coupling to the transport system. coded for in an operon essential for cell division; cell division ATP-binding protein FtsE 1846795..1847484 Mycobacterium marinum M 6225785 YP_001849837.1 CDS ftsX NC_010612.1 1847485 1848378 D involved in growth (principally during log phase cells). thought to be involved in active transport of septation component across the membrane. responsible for the translocation of the substrate across the membrane. coded for in an operon essential for ce; cell division protein FtsX 1847485..1848378 Mycobacterium marinum M 6225786 YP_001849838.1 CDS smpB NC_010612.1 1848381 1848887 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1848381..1848887 Mycobacterium marinum M 6225787 YP_001849839.1 CDS MMAR_1533 NC_010612.1 1848921 1849787 R hypothetical protein complement(1848921..1849787) Mycobacterium marinum M 6225788 YP_001849840.1 CDS MMAR_1534 NC_010612.1 1849784 1852123 R hypothetical protein complement(1849784..1852123) Mycobacterium marinum M 6225789 YP_001849841.1 CDS MMAR_1535 NC_010612.1 1852462 1853703 D ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolysis of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)]; ATPase 1852462..1853703 Mycobacterium marinum M 6225790 YP_001849842.1 CDS MMAR_1536 NC_010612.1 1853703 1854731 D hypothetical protein 1853703..1854731 Mycobacterium marinum M 6225791 YP_001849843.1 CDS MMAR_1537 NC_010612.1 1854756 1855601 D hypothetical protein 1854756..1855601 Mycobacterium marinum M 6225792 YP_001849844.1 CDS MMAR_1538 NC_010612.1 1856202 1857965 R PE family protein complement(1856202..1857965) Mycobacterium marinum M 6225794 YP_001849845.1 CDS MMAR_1539 NC_010612.1 1857969 1858196 R hypothetical protein complement(1857969..1858196) Mycobacterium marinum M 6225795 YP_001849846.1 CDS MMAR_5566 NC_010612.1 1858295 1858648 D hypothetical protein 1858295..1858648 Mycobacterium marinum M 6225796 YP_001849847.1 CDS MMAR_1540 NC_010612.1 1858688 1858951 R hypothetical protein complement(1858688..1858951) Mycobacterium marinum M 6225797 YP_001849848.1 CDS MMAR_1541 NC_010612.1 1859202 1859900 D hypothetical protein 1859202..1859900 Mycobacterium marinum M 6225798 YP_001849849.1 CDS MMAR_1542 NC_010612.1 1859944 1860810 R hypothetical protein complement(1859944..1860810) Mycobacterium marinum M 6225799 YP_001849850.1 CDS MMAR_1543 NC_010612.1 1860877 1861563 R hypothetical protein complement(1860877..1861563) Mycobacterium marinum M 6225800 YP_001849851.1 CDS MMAR_1544 NC_010612.1 1861606 1862223 R hypothetical protein complement(1861606..1862223) Mycobacterium marinum M 6225801 YP_001849852.1 CDS MMAR_1545 NC_010612.1 1862298 1863119 D hypothetical protein 1862298..1863119 Mycobacterium marinum M 6225802 YP_001849853.1 CDS MMAR_1546 NC_010612.1 1863166 1863687 R hypothetical protein complement(1863166..1863687) Mycobacterium marinum M 6225803 YP_001849854.1 CDS MMAR_1547 NC_010612.1 1864049 1865686 D PE-PGRS family protein 1864049..1865686 Mycobacterium marinum M 6225804 YP_001849855.1 CDS glsA NC_010612.1 1865754 1866716 D catalyzes the formation of glutamate from glutamine; glutaminase 1865754..1866716 Mycobacterium marinum M 6225805 YP_001849856.1 CDS MMAR_1549 NC_010612.1 1866810 1867232 D function unknown but has domain similarity to predicted flavin-nucleotide-binding proteins; hypothetical protein 1866810..1867232 Mycobacterium marinum M 6225806 YP_001849857.1 CDS MMAR_1550 NC_010612.1 1867237 1869276 R PPE family protein complement(1867237..1869276) Mycobacterium marinum M 6225807 YP_001849858.1 CDS MMAR_1551 NC_010612.1 1869605 1870468 R contains a phytanoyl-CoA dioxygenase domain; hypothetical protein complement(1869605..1870468) Mycobacterium marinum M 6225808 YP_001849859.1 CDS MMAR_1552 NC_010612.1 1870609 1870923 D hypothetical protein 1870609..1870923 Mycobacterium marinum M 6225809 YP_001849860.1 CDS MMAR_1553 NC_010612.1 1871130 1871618 D hypothetical protein 1871130..1871618 Mycobacterium marinum M 6225810 YP_001849861.1 CDS MMAR_1554 NC_010612.1 1871632 1872768 R hypothetical protein complement(1871632..1872768) Mycobacterium marinum M 6225811 YP_001849862.1 CDS MMAR_1555 NC_010612.1 1873029 1873505 R transcriptional regulatory protein complement(1873029..1873505) Mycobacterium marinum M 6225812 YP_001849863.1 CDS MMAR_1556 NC_010612.1 1873585 1874745 D dehydrogenase 1873585..1874745 Mycobacterium marinum M 6225813 YP_001849864.1 CDS MMAR_1557 NC_010612.1 1874742 1875719 D oxidoreductase 1874742..1875719 Mycobacterium marinum M 6225814 YP_001849865.1 CDS MMAR_1558 NC_010612.1 1875716 1876723 D NADP-dependent oxidoreductase 1875716..1876723 Mycobacterium marinum M 6225815 YP_001849866.1 CDS MMAR_1559 NC_010612.1 1876745 1878244 R hypothetical protein complement(1876745..1878244) Mycobacterium marinum M 6225816 YP_001849867.1 CDS MMAR_1560 NC_010612.1 1878286 1879266 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase complement(1878286..1879266) Mycobacterium marinum M 6225817 YP_001849868.1 CDS miaA_1 NC_010612.1 1879353 1880297 R catalyzes the first step in the biosynthesis of 2- methylthio-n6-(delta(2)-isopentenyl)-adenosine adjacent to the anticodon of several tRNA species [catalytic activity: isopentenyl diphosphate + tRNA = pyrophosphate + tRNA containing 6-isopentenyladenosine]; tRNA delta(2)-isopentenylpyrophosphate transferase MiaA complement(1879353..1880297) Mycobacterium marinum M 6225818 YP_001849869.1 CDS MMAR_1562 NC_010612.1 1880466 1881233 R function unknown contains C-term of lysine decarboxylase domain; hypothetical protein complement(1880466..1881233) Mycobacterium marinum M 6225819 YP_001849870.1 CDS MMAR_1563 NC_010612.1 1881230 1881691 R function unknown, contains domain identity with ring hydroxylating dioxygenase beta subunit. this subunit has a similar structure to NTF-2, ketosteroid isomerase and scytalone dehydratase.the degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the substrate by nonheme iron- containing dioxygenases; hypothetical protein complement(1881230..1881691) Mycobacterium marinum M 6225820 YP_001849871.1 CDS cyp276A1 NC_010612.1 1881688 1882923 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 276A1 Cyp276A1 complement(1881688..1882923) Mycobacterium marinum M 6225821 YP_001849872.1 CDS MMAR_1565 NC_010612.1 1882994 1883767 R function unknown, possible role in methylation of unknown substrate; methyltransferase complement(1882994..1883767) Mycobacterium marinum M 6225822 YP_001849873.1 CDS miaB NC_010612.1 1884059 1885648 R MiaB protein is involved in tRNA biogenesis. it is a bifunctional iron-sulphur enzyme, involved in both thiolation and methylation of isopentenyl-adenosine; 2-methylthioadenine synthetase complement(1884059..1885648) Mycobacterium marinum M 6225823 YP_001849874.1 CDS MMAR_1567 NC_010612.1 1886484 1887401 D hypothetical protein 1886484..1887401 Mycobacterium marinum M 6225824 YP_001849875.1 CDS MMAR_1568 NC_010612.1 1887418 1888221 R function unknown; possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase complement(1887418..1888221) Mycobacterium marinum M 6225825 YP_001849876.1 CDS MMAR_1569 NC_010612.1 1888254 1889021 R putative regulatory protein complement(1888254..1889021) Mycobacterium marinum M 6225826 YP_001849877.1 CDS MMAR_1570 NC_010612.1 1889075 1889719 R hypothetical protein complement(1889075..1889719) Mycobacterium marinum M 6225827 YP_001849878.1 CDS MMAR_1571 NC_010612.1 1889770 1891461 R function unknown but shares esterase domain identity; hypothetical protein complement(1889770..1891461) Mycobacterium marinum M 6225828 YP_001849879.1 CDS MMAR_1572 NC_010612.1 1891498 1892388 R function unknown, first 70 aa missing WRT to orthologues; hypothetical protein complement(1891498..1892388) Mycobacterium marinum M 6225829 YP_001849880.1 CDS MMAR_1573 NC_010612.1 1892549 1894012 R hypothetical protein complement(1892549..1894012) Mycobacterium marinum M 6225830 YP_001849881.1 CDS MMAR_1574 NC_010612.1 1894092 1894490 D hypothetical protein 1894092..1894490 Mycobacterium marinum M 6225831 YP_001849882.1 CDS MMAR_1575 NC_010612.1 1894499 1895326 D oxidoreductase 1894499..1895326 Mycobacterium marinum M 6225832 YP_001849883.1 CDS MMAR_1576 NC_010612.1 1895536 1895922 D hypothetical protein 1895536..1895922 Mycobacterium marinum M 6225833 YP_001849884.1 CDS MMAR_1577 NC_010612.1 1895944 1897755 R function unknown but domain homology to arylsulfatase a ( AslA )and related enzymes; hydrolase complement(1895944..1897755) Mycobacterium marinum M 6225834 YP_001849885.1 CDS MMAR_1578 NC_010612.1 1897748 1898167 R hypothetical protein complement(1897748..1898167) Mycobacterium marinum M 6225835 YP_001849886.1 CDS MMAR_1579 NC_010612.1 1898311 1899984 R hypothetical protein complement(1898311..1899984) Mycobacterium marinum M 6225836 YP_001849887.1 CDS MMAR_1580 NC_010612.1 1900048 1901472 R function unknown; probably involved in cellular metabolism; dehydrogenase complement(1900048..1901472) Mycobacterium marinum M 6225837 YP_001849888.1 CDS MMAR_1581 NC_010612.1 1901469 1903286 R hypothetical protein complement(1901469..1903286) Mycobacterium marinum M 6225838 YP_001849889.1 CDS MMAR_1582 NC_010612.1 1903478 1904755 D function unknown but domain identity suggests transcriptional regulator; hypothetical protein 1903478..1904755 Mycobacterium marinum M 6225839 YP_001849890.1 CDS citE_2 NC_010612.1 1904846 1905781 D interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate lyase beta subunit, CitE_2 1904846..1905781 Mycobacterium marinum M 6225840 YP_001849891.1 CDS MMAR_1584 NC_010612.1 1905803 1907077 R function unknown; hypothetical protein complement(1905803..1907077) Mycobacterium marinum M 6225841 YP_001849892.1 CDS MMAR_1585 NC_010612.1 1907135 1907491 D hypothetical protein 1907135..1907491 Mycobacterium marinum M 6225842 YP_001849893.1 CDS MMAR_1586 NC_010612.1 1907533 1908411 D oxidoreductase 1907533..1908411 Mycobacterium marinum M 6225843 YP_001849894.1 CDS MMAR_1587 NC_010612.1 1908425 1909048 D hypothetical protein 1908425..1909048 Mycobacterium marinum M 6225844 YP_001849895.1 CDS MMAR_1588 NC_010612.1 1909059 1910165 R hypothetical protein complement(1909059..1910165) Mycobacterium marinum M 6225845 YP_001849896.1 CDS MMAR_1589 NC_010612.1 1910162 1910536 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1910162..1910536) Mycobacterium marinum M 6225846 YP_001849897.1 CDS MMAR_1590 NC_010612.1 1910536 1910931 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1910536..1910931) Mycobacterium marinum M 6225847 YP_001849898.1 CDS pgmA NC_010612.1 1911059 1912690 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 1911059..1912690 Mycobacterium marinum M 6225848 YP_001849899.1 CDS MMAR_1592 NC_010612.1 1912943 1913212 D hypothetical protein 1912943..1913212 Mycobacterium marinum M 6225850 YP_001849900.1 CDS MMAR_1594 NC_010612.1 1918529 1929433 R PE-PGRS family protein complement(1918529..1929433) Mycobacterium marinum M 6225852 YP_001849901.1 CDS MMAR_1595 NC_010612.1 1931701 1932657 D secondary metabolites biosynthesis, transport, and catabolism; O-methyltransferase 1931701..1932657 Mycobacterium marinum M 6225853 YP_001849902.1 CDS MMAR_1596 NC_010612.1 1932650 1933411 D function unknown, contains a SAM-dependent methyltransferase domain; hypothetical protein 1932650..1933411 Mycobacterium marinum M 6225854 YP_001849903.1 CDS MMAR_1597 NC_010612.1 1933569 1934207 D involved in transcriptional mechanism; transcriptional regulatory protein 1933569..1934207 Mycobacterium marinum M 6225855 YP_001849904.1 CDS MMAR_1598 NC_010612.1 1934672 1934905 D single copy element; transposition of an ISMyma01-like insertion sequence; transposase 1934672..1934905 Mycobacterium marinum M 6225856 YP_001849905.1 CDS MMAR_1599 NC_010612.1 1935049 1935738 D single copy element; transposition of an ISMyma01-like element; transposase 1935049..1935738 Mycobacterium marinum M 6225857 YP_001849906.1 CDS MMAR_1600 NC_010612.1 1935870 1936259 D hypothetical protein 1935870..1936259 Mycobacterium marinum M 6225858 YP_001849907.1 CDS MMAR_1601 NC_010612.1 1936366 1936956 R PE-PGRS family protein complement(1936366..1936956) Mycobacterium marinum M 6225859 YP_001849908.1 CDS MMAR_1602 NC_010612.1 1937328 1939301 D function unknown, probably involved in cellular metabolism; oxidoreductase GMC-type 1937328..1939301 Mycobacterium marinum M 6225860 YP_001849909.1 CDS MMAR_1603 NC_010612.1 1939337 1940602 R hypothetical protein complement(1939337..1940602) Mycobacterium marinum M 6225861 YP_001849910.1 CDS MMAR_1604 NC_010612.1 1940884 1941774 D function unknown but contains Cdd pfam03982, DAGAT, diacylglycerol acyltransferase domain; hypothetical protein 1940884..1941774 Mycobacterium marinum M 6225862 YP_001849911.1 CDS MMAR_1605 NC_010612.1 1941781 1943313 D hypothetical protein 1941781..1943313 Mycobacterium marinum M 6225863 YP_001849912.1 CDS MMAR_1606 NC_010612.1 1943310 1944797 D function unknown, but involved in lipid degradation; fatty-acid-CoA ligase 1943310..1944797 Mycobacterium marinum M 6225864 YP_001849913.1 CDS putA_2 NC_010612.1 1944890 1946437 D involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H]; succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 1944890..1946437 Mycobacterium marinum M 6225865 YP_001849914.1 CDS MMAR_1608 NC_010612.1 1946454 1948334 R function unknown, probably involved in cellular metabolism; hydrolase complement(1946454..1948334) Mycobacterium marinum M 6225866 YP_001849915.1 CDS MMAR_1609 NC_010612.1 1948370 1948930 R hypothetical protein complement(1948370..1948930) Mycobacterium marinum M 6225867 YP_001849916.1 CDS MMAR_1610 NC_010612.1 1949017 1949265 R hypothetical protein complement(1949017..1949265) Mycobacterium marinum M 6225868 YP_001849917.1 CDS MMAR_1611 NC_010612.1 1949422 1950000 R involved in transcriptional mechanism; transcriptional regulatory protein complement(1949422..1950000) Mycobacterium marinum M 6225869 YP_001849918.1 CDS mmr NC_010612.1 1949997 1950320 R involved in transport of multidrugs (tetraphenylphosphonium, erythromycin, ethidium bromide, acriflavine, safranin O, pyronin Y, etc) across the membrane (export): multidrugs resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; multidrug-transport integral membrane protein Mmr complement(1949997..1950320) Mycobacterium marinum M 6225870 YP_001849919.1 CDS MMAR_1613 NC_010612.1 1950389 1951024 R hypothetical protein complement(1950389..1951024) Mycobacterium marinum M 6225871 YP_001849920.1 CDS MMAR_1614 NC_010612.1 1951114 1951944 R short chain dehydrogenase complement(1951114..1951944) Mycobacterium marinum M 6225872 YP_001849921.1 CDS dnaK1 NC_010612.1 1951969 1953507 R acts as a chaperone. involved in induction by stress conditions E.G. heat shock. possibly has an ATPase activity. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR; chaperone protein DnaK1 complement(1951969..1953507) Mycobacterium marinum M 6225873 YP_001849922.1 CDS cstA NC_010612.1 1953590 1955866 R peptide utilization during carbon starvation; carbon starvation protein, CstA complement(1953590..1955866) Mycobacterium marinum M 6225874 YP_001849923.1 CDS cueO NC_010612.1 1956244 1957884 D Catalyses the oxidation of cuprous copper, ferrous iron and diphenolic compounds. Protects against oxidative stress; multicopper oxidase, type 1, CueO 1956244..1957884 Mycobacterium marinum M 6225875 YP_001849924.1 CDS MMAR_1619 NC_010612.1 1957881 1958600 D hypothetical protein 1957881..1958600 Mycobacterium marinum M 6225876 YP_001849925.1 CDS MMAR_1620 NC_010612.1 1958846 1959430 D hypothetical protein 1958846..1959430 Mycobacterium marinum M 6225877 YP_001849926.1 CDS MMAR_1621 NC_010612.1 1959445 1960179 R involved in transcriptional mechanism; transcriptional regulatory protein complement(1959445..1960179) Mycobacterium marinum M 6225878 YP_001849927.1 CDS MMAR_1622 NC_010612.1 1960367 1960861 D hypothetical protein 1960367..1960861 Mycobacterium marinum M 6225879 YP_001849928.1 CDS ligB NC_010612.1 1960866 1962371 R catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase complement(1960866..1962371) Mycobacterium marinum M 6225880 YP_001849929.1 CDS MMAR_1624 NC_010612.1 1962516 1963274 D function unknown, supposed involved in cellular metabolism; short-chain type dehydrogenase/reductase 1962516..1963274 Mycobacterium marinum M 6225881 YP_001849930.1 CDS fadE22 NC_010612.1 1963385 1965550 D function unknown, but involved in lipid metabolism; acyl-CoA dehydrogenase FadE22 1963385..1965550 Mycobacterium marinum M 6225882 YP_001849931.1 CDS MMAR_1626 NC_010612.1 1965584 1966258 R transcriptional regulator complement(1965584..1966258) Mycobacterium marinum M 6225883 YP_001849932.1 CDS MMAR_1627 NC_010612.1 1966424 1967254 D methyltransferase 1966424..1967254 Mycobacterium marinum M 6225884 YP_001849933.1 CDS MMAR_1628 NC_010612.1 1967255 1967611 R function unknown but potential nucleic-acid-binding domain; hypothetical protein complement(1967255..1967611) Mycobacterium marinum M 6225885 YP_001849934.1 CDS MMAR_1629 NC_010612.1 1967662 1968855 D function unknown, supposed involvement in lipid metabolism; acetyl-CoA acetyltransferase 1967662..1968855 Mycobacterium marinum M 6225886 YP_001849935.1 CDS MMAR_1630 NC_010612.1 1968869 1970344 D involved in transcriptional mechanism; transcriptional regulatory protein 1968869..1970344 Mycobacterium marinum M 6225887 YP_001849936.1 CDS MMAR_1631 NC_010612.1 1970467 1971429 D hypothetical protein 1970467..1971429 Mycobacterium marinum M 6225888 YP_001849937.1 CDS MMAR_1632 NC_010612.1 1971471 1971764 R hypothetical protein complement(1971471..1971764) Mycobacterium marinum M 6225889 YP_001849938.1 CDS MMAR_1633 NC_010612.1 1971935 1972465 D hypothetical protein 1971935..1972465 Mycobacterium marinum M 6225890 YP_001849939.1 CDS cyp136A2 NC_010612.1 1972493 1973971 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 136A2 Cyp136A2 complement(1972493..1973971) Mycobacterium marinum M 6225891 YP_001849940.1 CDS MMAR_1635 NC_010612.1 1974082 1974735 D involved in transcriptional mechanism; TetR family transcriptional regulator 1974082..1974735 Mycobacterium marinum M 6225892 YP_001849941.1 CDS MMAR_1636 NC_010612.1 1974808 1975683 D function unknown, but similar to various oxidoreductases and enzymes involved in polyketides synthesis; short chain dehydrogenase 1974808..1975683 Mycobacterium marinum M 6225893 YP_001849942.1 CDS MMAR_1637 NC_010612.1 1975724 1976326 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(1975724..1976326) Mycobacterium marinum M 6225894 YP_001849943.1 CDS MMAR_1638 NC_010612.1 1976417 1976974 D function unknown but domain identity suggests NADPH- dependent FMN reductase; hypothetical protein 1976417..1976974 Mycobacterium marinum M 6225895 YP_001849944.1 CDS MMAR_1639 NC_010612.1 1977457 1985721 D PPE family protein 1977457..1985721 Mycobacterium marinum M 6225896 YP_001849945.1 CDS nrdH NC_010612.1 1986233 1986472 D involved in electron transfer system for ribonucleotide reductase system NRDEF; glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH 1986233..1986472 Mycobacterium marinum M 6225897 YP_001849946.1 CDS nrdI NC_010612.1 1986516 1986977 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 1986516..1986977 Mycobacterium marinum M 6225898 YP_001849947.1 CDS nrdE NC_010612.1 1986947 1989112 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1986947..1989112 Mycobacterium marinum M 6225899 YP_001849948.1 CDS MMAR_1643 NC_010612.1 1989227 1989970 D involved in transcriptional mechanism; AsnC family transcriptional regulator 1989227..1989970 Mycobacterium marinum M 6225900 YP_001849949.1 CDS MMAR_1644 NC_010612.1 1990089 1991639 D function unknown, involved in cellular metabolism; monooxygenase 1990089..1991639 Mycobacterium marinum M 6225901 YP_001849950.1 CDS MMAR_1645 NC_010612.1 1991629 1992174 R involved in transcriptional mechanism; transcriptional regulatory protein complement(1991629..1992174) Mycobacterium marinum M 6225902 YP_001849951.1 CDS MMAR_1646 NC_010612.1 1992152 1992598 R hypothetical protein complement(1992152..1992598) Mycobacterium marinum M 6225903 YP_001849952.1 CDS nrdF NC_010612.1 1992809 1993783 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1992809..1993783 Mycobacterium marinum M 6225904 YP_001849953.1 CDS MMAR_1648 NC_010612.1 1993818 1994294 D hypothetical protein 1993818..1994294 Mycobacterium marinum M 6225905 YP_001849954.1 CDS adh NC_010612.1 1994283 1995323 R alcohol dehydrogenase catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: ethanol + NAD = acetaldehyde + NADH. belongs to the zinc-containing 'long-chain' alcohol dehydrogenases; NADP-dependent alcohol dehydrogenase Adh complement(1994283..1995323) Mycobacterium marinum M 6225906 YP_001849955.1 CDS fecB NC_010612.1 1995457 1996551 R may be involved in active transport of FeIII- decitrate across the membrane (import); FEIII-dicitrate-binding periplasmic lipoprotein FecB complement(1995457..1996551) Mycobacterium marinum M 6225907 YP_001849956.1 CDS ctaD NC_010612.1 1996730 1998451 D cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C]; cytochrome C oxidase polypeptide I CtaD 1996730..1998451 Mycobacterium marinum M 6225908 YP_001849957.1 CDS serB2 NC_010612.1 1998504 1999739 D generates serine from phosphoserine [catalytic activity: phosphoserine + H(2)O = serine + phosphate]; phosphoserine phosphatase SerB2 1998504..1999739 Mycobacterium marinum M 6225909 YP_001849958.1 CDS MMAR_1653 NC_010612.1 1999921 2000265 D involved in transcriptional mechanism; transcriptional regulatory protein 1999921..2000265 Mycobacterium marinum M 6225910 YP_001849959.1 CDS MMAR_1654 NC_010612.1 2000280 2000759 D function unknown, probably involved in cellular metabolism; oxidoreductase 2000280..2000759 Mycobacterium marinum M 6225911 YP_001849960.1 CDS MMAR_1655 NC_010612.1 2000756 2002732 D function unknown, probably involved in cellular metabolism; oxidoreductase 2000756..2002732 Mycobacterium marinum M 6225912 YP_001849961.1 CDS hycD NC_010612.1 2002729 2003688 D involved in hydrogen metabolism; FHL pathway; formate hydrogenlyase HycD 2002729..2003688 Mycobacterium marinum M 6225913 YP_001849962.1 CDS hycP NC_010612.1 2003693 2004355 D involved in hydrogen metabolism; hydrogenase HycP 2003693..2004355 Mycobacterium marinum M 6225914 YP_001849963.1 CDS hycQ NC_010612.1 2004355 2005821 D possibly involved in hydrogen metabolism; hydrogenase HycQ 2004355..2005821 Mycobacterium marinum M 6225915 YP_001849964.1 CDS hycE NC_010612.1 2005821 2007317 D involved in hydrogen metabolism; FHL pathway; formate hydrogenase HycE 2005821..2007317 Mycobacterium marinum M 6225916 YP_001849965.1 CDS MMAR_1660 NC_010612.1 2007416 2008258 D thought to be involved in active transport of undeterminated substrate (possibly iron) across the membrane. responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 2007416..2008258 Mycobacterium marinum M 6225917 YP_001849966.1 CDS MMAR_1661 NC_010612.1 2008255 2009097 D hypothetical protein 2008255..2009097 Mycobacterium marinum M 6225918 YP_001849967.1 CDS echA17 NC_010612.1 2009094 2009867 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2009094..2009867 Mycobacterium marinum M 6225919 YP_001849968.1 CDS MMAR_1663 NC_010612.1 2009878 2010861 D hypothetical protein 2009878..2010861 Mycobacterium marinum M 6225920 YP_001849969.1 CDS MMAR_1664 NC_010612.1 2011026 2012063 D hypothetical protein 2011026..2012063 Mycobacterium marinum M 6225921 YP_001849970.1 CDS MMAR_1665 NC_010612.1 2012147 2012821 D hypothetical protein 2012147..2012821 Mycobacterium marinum M 6225922 YP_001849971.1 CDS MMAR_1666 NC_010612.1 2012825 2013214 R hypothetical protein complement(2012825..2013214) Mycobacterium marinum M 6225923 YP_001849972.1 CDS MMAR_1667 NC_010612.1 2013231 2014547 R hypothetical protein complement(2013231..2014547) Mycobacterium marinum M 6225924 YP_001849973.1 CDS MMAR_1668 NC_010612.1 2014724 2015461 D function unknown, possibly involved in cellular metabolism; transferase 2014724..2015461 Mycobacterium marinum M 6225925 YP_001849974.1 CDS MMAR_1669 NC_010612.1 2015482 2016261 R function unknown; probably involved in lipid metabolism; lysophospholipase complement(2015482..2016261) Mycobacterium marinum M 6225926 YP_001849975.1 CDS MMAR_1670 NC_010612.1 2016286 2016831 R hypothetical protein complement(2016286..2016831) Mycobacterium marinum M 6225927 YP_001849976.1 CDS phrI NC_010612.1 2016958 2018301 R function unknown, possible role in DNA replication, recombination, and repair; DNA photolyase, PhrI complement(2016958..2018301) Mycobacterium marinum M 6225928 YP_001849977.1 CDS MMAR_1672 NC_010612.1 2018310 2018789 R function unknown. possibly involved in signal transduction mechanisms; tryptophan-rich sensory protein complement(2018310..2018789) Mycobacterium marinum M 6225929 YP_001849978.1 CDS MMAR_1673 NC_010612.1 2018786 2020900 R function unknown. thought to be involved in drug export; transmembrane transport protein complement(2018786..2020900) Mycobacterium marinum M 6225930 YP_001849979.1 CDS ampC NC_010612.1 2021115 2022323 D thought to be involved in cell wall biosynthesis and may also act as a sensor of external penicillins; beta-lactamase 2021115..2022323 Mycobacterium marinum M 6225931 YP_001849980.1 CDS MMAR_1675 NC_010612.1 2022434 2022937 D transcriptional regulation; transcriptional regulator 2022434..2022937 Mycobacterium marinum M 6225932 YP_001849981.1 CDS MMAR_1676 NC_010612.1 2022940 2023347 R hypothetical protein complement(2022940..2023347) Mycobacterium marinum M 6225933 YP_001849982.1 CDS MMAR_1677 NC_010612.1 2023521 2024162 D hypothetical protein 2023521..2024162 Mycobacterium marinum M 6225934 YP_001849983.1 CDS MMAR_1678 NC_010612.1 2024351 2025046 D hypothetical protein 2024351..2025046 Mycobacterium marinum M 6225935 YP_001849984.1 CDS MMAR_1679 NC_010612.1 2025051 2026406 R hypothetical protein complement(2025051..2026406) Mycobacterium marinum M 6225936 YP_001849985.1 CDS MMAR_1680 NC_010612.1 2026473 2027450 D function unknown, probably involved in cellular metabolism; dehydrogenase/reductase 2026473..2027450 Mycobacterium marinum M 6225937 YP_001849986.1 CDS MMAR_1681 NC_010612.1 2027447 2028691 R function unknown, possibly involved in cellular metabolism; transferase complement(2027447..2028691) Mycobacterium marinum M 6225938 YP_001849987.1 CDS MMAR_1682 NC_010612.1 2028783 2030378 R hypothetical protein complement(2028783..2030378) Mycobacterium marinum M 6225939 YP_001849988.1 CDS MMAR_1683 NC_010612.1 2030375 2031193 R hypothetical protein complement(2030375..2031193) Mycobacterium marinum M 6225940 YP_001849989.1 CDS fixA NC_010612.1 2031466 2032257 D the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase); electron transfer flavoprotein FixA 2031466..2032257 Mycobacterium marinum M 6225941 YP_001849990.1 CDS fixB NC_010612.1 2032305 2033261 D the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase); electron transfer flavoprotein FixB 2032305..2033261 Mycobacterium marinum M 6225942 YP_001849991.1 CDS MMAR_1686 NC_010612.1 2033405 2034265 D hypothetical protein 2033405..2034265 Mycobacterium marinum M 6225943 YP_001849992.1 CDS MMAR_1687 NC_010612.1 2034265 2035101 D hypothetical protein 2034265..2035101 Mycobacterium marinum M 6225944 YP_001849993.1 CDS MMAR_1688 NC_010612.1 2035181 2035681 D hypothetical protein 2035181..2035681 Mycobacterium marinum M 6225945 YP_001849994.1 CDS iscS NC_010612.1 2035742 2036923 D catalyzes the removal of elemental sulfur from cysteine to produce alanine; cysteine desulfurase IscS 2035742..2036923 Mycobacterium marinum M 6225946 YP_001849995.1 CDS mnmA NC_010612.1 2036938 2038011 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2036938..2038011 Mycobacterium marinum M 6225947 YP_001849996.1 CDS lpqA NC_010612.1 2038008 2038637 R lipoprotein LpqA complement(2038008..2038637) Mycobacterium marinum M 6225948 YP_001849997.1 CDS MMAR_1692 NC_010612.1 2038733 2039746 D hypothetical protein 2038733..2039746 Mycobacterium marinum M 6225949 YP_001849998.1 CDS MMAR_1693 NC_010612.1 2040072 2041568 D causes methylation; methyltransferase 2040072..2041568 Mycobacterium marinum M 6225950 YP_001849999.1 CDS ligA NC_010612.1 2041858 2043921 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2041858..2043921 Mycobacterium marinum M 6225951 YP_001850000.1 CDS MMAR_1695 NC_010612.1 2043991 2044587 D possibly involved in a transcriptional mechanism; regulatory protein 2043991..2044587 Mycobacterium marinum M 6225952 YP_001850001.1 CDS MMAR_1696 NC_010612.1 2044760 2045191 D hypothetical protein 2044760..2045191 Mycobacterium marinum M 6225953 YP_001850002.1 CDS MMAR_1698 NC_010612.1 2045562 2045843 D transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 2045562..2045843 Mycobacterium marinum M 6225955 YP_001850003.1 CDS MMAR_1699 NC_010612.1 2045885 2046679 D transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 2045885..2046679 Mycobacterium marinum M 6225956 YP_001850004.1 CDS MMAR_1700 NC_010612.1 2049340 2050032 R hypothetical protein complement(2049340..2050032) Mycobacterium marinum M 6225957 YP_001850005.1 CDS gatC NC_010612.1 2050154 2050453 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 2050154..2050453 Mycobacterium marinum M 6225958 YP_001850006.1 CDS gatA NC_010612.1 2050450 2051931 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 2050450..2051931 Mycobacterium marinum M 6225959 YP_001850007.1 CDS pfkA NC_010612.1 2052031 2053062 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 2052031..2053062 Mycobacterium marinum M 6225960 YP_001850008.1 CDS gatB NC_010612.1 2053345 2054853 D allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 2053345..2054853 Mycobacterium marinum M 6225961 YP_001850009.1 CDS MMAR_1705 NC_010612.1 2054890 2055489 D function unknown; probably involved in cellular metabolism; oxidoreductase 2054890..2055489 Mycobacterium marinum M 6225962 YP_001850010.1 CDS lppZ NC_010612.1 2055515 2056636 R lipoprotein LppZ complement(2055515..2056636) Mycobacterium marinum M 6225963 YP_001850011.1 CDS MMAR_1707 NC_010612.1 2056867 2057715 D hypothetical protein 2056867..2057715 Mycobacterium marinum M 6225964 YP_001850012.1 CDS cfp6 NC_010612.1 2057724 2058101 R function unknown function (putative membrane protein); low molecular weight protein antigen 6, Cfp6 complement(2057724..2058101) Mycobacterium marinum M 6225965 YP_001850013.1 CDS MMAR_1709 NC_010612.1 2058155 2058286 D hypothetical protein 2058155..2058286 Mycobacterium marinum M 6225966 YP_001850014.1 CDS ilvB1 NC_010612.1 2058430 2060286 D acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 2058430..2060286 Mycobacterium marinum M 6225967 YP_001850015.1 CDS ilvH NC_010612.1 2060286 2060795 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 2060286..2060795 Mycobacterium marinum M 6225968 YP_001850016.1 CDS ilvC NC_010612.1 2060838 2061869 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 2060838..2061869 Mycobacterium marinum M 6225969 YP_001850017.1 CDS MMAR_1713 NC_010612.1 2061956 2062558 R hypothetical protein complement(2061956..2062558) Mycobacterium marinum M 6225970 YP_001850018.1 CDS MMAR_1714 NC_010612.1 2062555 2063985 R function unknown; probably involved in cellular metabolism; alanine rich dehydrogenase complement(2062555..2063985) Mycobacterium marinum M 6225971 YP_001850019.1 CDS serA1 NC_010612.1 2064016 2065602 D catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2064016..2065602 Mycobacterium marinum M 6225972 YP_001850020.1 CDS leuB NC_010612.1 2065658 2066677 D catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 2065658..2066677 Mycobacterium marinum M 6225973 YP_001850021.1 CDS MMAR_1717 NC_010612.1 2066577 2067881 R function unknown; contains major facilitator superfamily (MFS). the MFS transporters are single- polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients; integral membrane transport protein complement(2066577..2067881) Mycobacterium marinum M 6225974 YP_001850022.1 CDS MMAR_1718 NC_010612.1 2068184 2068981 D isomerizes HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) to ohed (2-OXO-hept-3-ene-1,7-dioate); 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 2068184..2068981 Mycobacterium marinum M 6225975 YP_001850023.1 CDS gltX NC_010612.1 2068978 2070447 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2068978..2070447 Mycobacterium marinum M 6225976 YP_001850024.1 CDS MMAR_1720 NC_010612.1 2070824 2071345 R hypothetical protein complement(2070824..2071345) Mycobacterium marinum M 6225979 YP_001850025.1 CDS MMAR_1721 NC_010612.1 2071498 2072463 D hypothetical protein 2071498..2072463 Mycobacterium marinum M 6225980 YP_001850026.1 CDS mmpL1_1 NC_010612.1 2072489 2075350 R function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(2072489..2075350) Mycobacterium marinum M 6225981 YP_001850027.1 CDS mmpS1 NC_010612.1 2075347 2075775 R membrane protein MmpS1 complement(2075347..2075775) Mycobacterium marinum M 6225982 YP_001850028.1 CDS bioF2_2 NC_010612.1 2075994 2077244 R could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase complement(2075994..2077244) Mycobacterium marinum M 6225983 YP_001850029.1 CDS MMAR_1725 NC_010612.1 2077795 2078496 R involved in transcriptional mechanism; transcriptional regulatory protein complement(2077795..2078496) Mycobacterium marinum M 6225984 YP_001850030.1 CDS leuC NC_010612.1 2078579 2080000 D dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 2078579..2080000 Mycobacterium marinum M 6225985 YP_001850031.1 CDS leuD NC_010612.1 2080025 2080621 D catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 2080025..2080621 Mycobacterium marinum M 6225986 YP_001850032.1 CDS hupB NC_010612.1 2080846 2081508 D this protein belongs to the histone like family of prokaryotic DNA-binding proteins which are capable of wrapping DNA to stabilize it, and prevent its denaturation under extreme environmental conditions; DNA-binding protein HU, HupB 2080846..2081508 Mycobacterium marinum M 6225987 YP_001850033.1 CDS mutT1 NC_010612.1 2081570 2082508 R function unknown, hydrolytic enzyme. possibly involved in removal of damaged nucleotide; hydrolase MutT1 complement(2081570..2082508) Mycobacterium marinum M 6225988 YP_001850034.1 CDS ppk NC_010612.1 2082588 2084804 R catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase complement(2082588..2084804) Mycobacterium marinum M 6225989 YP_001850035.1 CDS MMAR_1731 NC_010612.1 2084883 2085536 R hypothetical protein complement(2084883..2085536) Mycobacterium marinum M 6225990 YP_001850036.1 CDS gpsA NC_010612.1 2085728 2086735 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2085728..2086735 Mycobacterium marinum M 6225991 YP_001850037.1 CDS ddl NC_010612.1 2086827 2087948 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 2086827..2087948 Mycobacterium marinum M 6225992 YP_001850038.1 CDS MMAR_1734 NC_010612.1 2087945 2088571 R hypothetical protein complement(2087945..2088571) Mycobacterium marinum M 6225993 YP_001850039.1 CDS thiL NC_010612.1 2088737 2089702 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 2088737..2089702 Mycobacterium marinum M 6225994 YP_001850040.1 CDS MMAR_1736 NC_010612.1 2089728 2090018 D hypothetical protein 2089728..2090018 Mycobacterium marinum M 6225995 YP_001850041.1 CDS ung NC_010612.1 2090015 2090698 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2090015..2090698 Mycobacterium marinum M 6225996 YP_001850042.1 CDS MMAR_1738 NC_010612.1 2090704 2091636 D thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle; oxidoreductase 2090704..2091636 Mycobacterium marinum M 6225997 YP_001850043.1 CDS MMAR_1739 NC_010612.1 2091686 2092336 D function unknown; probably involved in cellular metabolism; nitroreductase 2091686..2092336 Mycobacterium marinum M 6225998 YP_001850044.1 CDS rpmB NC_010612.1 2092492 2092686 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(2092492..2092686) Mycobacterium marinum M 6225999 YP_001850045.1 CDS MMAR_1741 NC_010612.1 2092969 2094663 D hypothetical protein 2092969..2094663 Mycobacterium marinum M 6226000 YP_001850046.1 CDS recG NC_010612.1 2094666 2096897 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 2094666..2096897 Mycobacterium marinum M 6226001 YP_001850047.1 CDS MMAR_1743 NC_010612.1 2096902 2097615 D hypothetical protein 2096902..2097615 Mycobacterium marinum M 6226002 YP_001850048.1 CDS MMAR_1744 NC_010612.1 2097620 2098465 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(2097620..2098465) Mycobacterium marinum M 6226003 YP_001850049.1 CDS MMAR_1745 NC_010612.1 2098655 2098990 R hypothetical protein complement(2098655..2098990) Mycobacterium marinum M 6226004 YP_001850050.1 CDS lipN NC_010612.1 2099035 2100153 D function unknown, lipolytic enzyme involved in cellular metabolism; lipase/esterase LipN 2099035..2100153 Mycobacterium marinum M 6226005 YP_001850051.1 CDS MMAR_1747 NC_010612.1 2100340 2101107 D hypothetical protein 2100340..2101107 Mycobacterium marinum M 6226006 YP_001850052.1 CDS MMAR_1748 NC_010612.1 2101113 2101751 D integral membrane protein 2101113..2101751 Mycobacterium marinum M 6226007 YP_001850053.1 CDS pca NC_010612.1 2101794 2105189 D biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 2101794..2105189 Mycobacterium marinum M 6226008 YP_001850054.1 CDS MMAR_1750 NC_010612.1 2105267 2105740 D thought to cause methylation; methyltransferase 2105267..2105740 Mycobacterium marinum M 6226009 YP_001850055.1 CDS coaD NC_010612.1 2105814 2106287 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 2105814..2106287 Mycobacterium marinum M 6226010 YP_001850056.1 CDS MMAR_1752 NC_010612.1 2106371 2106553 R hypothetical protein complement(2106371..2106553) Mycobacterium marinum M 6226011 YP_001850057.1 CDS purU NC_010612.1 2106710 2107606 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(2106710..2107606) Mycobacterium marinum M 6226012 YP_001850058.1 CDS MMAR_1754 NC_010612.1 2107640 2108821 R hypothetical protein complement(2107640..2108821) Mycobacterium marinum M 6226013 YP_001850059.1 CDS MMAR_1755 NC_010612.1 2109311 2110573 D involved in PGL biosynthesis. in M. tuberculosis H37Rv, the product of the mu orthologue (Rv2962c) catalyzes the transfer of a rhamnosyl residue onto p- hydroxybenzoic acid ethyl ester or phenolphthiocerol dimycocerosates; glycosyl transferase family protein 2109311..2110573 Mycobacterium marinum M 6226014 YP_001850060.1 CDS MMAR_1756 NC_010612.1 2110734 2111531 D hypothetical protein 2110734..2111531 Mycobacterium marinum M 6226015 YP_001850061.1 CDS MMAR_1757 NC_010612.1 2111582 2112838 R hypothetical protein complement(2111582..2112838) Mycobacterium marinum M 6226016 YP_001850062.1 CDS MMAR_1758 NC_010612.1 2113051 2114208 D function unknown; probably involved in cellular metabolism; ketoreductase 2113051..2114208 Mycobacterium marinum M 6226017 YP_001850063.1 CDS fadD29 NC_010612.1 2115037 2116905 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2115037..2116905 Mycobacterium marinum M 6226018 YP_001850064.1 CDS MMAR_1760 NC_010612.1 2116910 2117548 D responsible for the direct conversion of chorismate to p-hydroxybenzoate, the substrate used in the production of glycosylated p-hydroxybenzoic acid methyl esters and structurally related phenolphthiocerol glycolipids. in M. tuberculosis, this is the sole enzymatic source of p- hydroxybenzoic acid; chorismate pyruvate-lyase 2116910..2117548 Mycobacterium marinum M 6226019 YP_001850065.1 CDS fadD22 NC_010612.1 2117667 2119775 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2117667..2119775 Mycobacterium marinum M 6226020 YP_001850066.1 CDS pks15/1 NC_010612.1 2119792 2126106 D polyketide synthase required for the elongation of p-HBAD derivatives to form p-hydroxybenzoate derivatives which are in turn converted to phenolphthiocerols by the ppsA-E locus. this is a key step in the production of phenolic glycolipids; polyketide synthase 2119792..2126106 Mycobacterium marinum M 6226021 YP_001850067.1 CDS lppX NC_010612.1 2126521 2127210 D lipoprotein LppX 2126521..2127210 Mycobacterium marinum M 6226022 YP_001850068.1 CDS mmpL7 NC_010612.1 2127250 2130000 R involved in translocation of phthiocerol dimycocerosate (dim) in the cell wall; transmembrane transport protein MmpL7 complement(2127250..2130000) Mycobacterium marinum M 6226023 YP_001850069.1 CDS fadD28 NC_010612.1 2130002 2131744 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(2130002..2131744) Mycobacterium marinum M 6226024 YP_001850070.1 CDS MMAR_1766 NC_010612.1 2132180 2132992 D function unknown but orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form dim; methyltransferase 2132180..2132992 Mycobacterium marinum M 6226025 YP_001850071.1 CDS mas NC_010612.1 2133553 2139852 D catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids; multifunctional mycocerosic acid synthase membrane-associated Mas 2133553..2139852 Mycobacterium marinum M 6226026 YP_001850072.1 CDS papA5 NC_010612.1 2140056 2141300 R required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase PapA5 complement(2140056..2141300) Mycobacterium marinum M 6226027 YP_001850073.1 CDS drrC NC_010612.1 2141334 2142155 R probably involved in active transport of phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall; daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC complement(2141334..2142155) Mycobacterium marinum M 6226028 YP_001850074.1 CDS drrB NC_010612.1 2142161 2143030 R probably involved in active transport of phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall; daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB complement(2142161..2143030) Mycobacterium marinum M 6226029 YP_001850075.1 CDS drrA NC_010612.1 2143027 2144022 R probably involved in active transport of antibiotic and phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. responsible for energy coupling to the transport system; daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA complement(2143027..2144022) Mycobacterium marinum M 6226030 YP_001850076.1 CDS ppsE NC_010612.1 2144033 2148478 R involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (partial reduction, decarboxylation); phenolpthiocerol synthesis type-I polyketide synthase PpsE complement(2144033..2148478) Mycobacterium marinum M 6226031 YP_001850077.1 CDS ppsD NC_010612.1 2148484 2153904 R involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with methylmalony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsD complement(2148484..2153904) Mycobacterium marinum M 6226032 YP_001850078.1 CDS ppsC NC_010612.1 2153904 2160509 R involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (complete reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsC complement(2153904..2160509) Mycobacterium marinum M 6226033 YP_001850079.1 CDS ppsB NC_010612.1 2160509 2165083 R involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsB complement(2160509..2165083) Mycobacterium marinum M 6226034 YP_001850080.1 CDS ppsA NC_010612.1 2165083 2169891 R involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension of C18 with Malony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsA complement(2165083..2169891) Mycobacterium marinum M 6226035 YP_001850081.1 CDS fadD26 NC_010612.1 2169888 2171642 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(2169888..2171642) Mycobacterium marinum M 6226036 YP_001850082.1 CDS tesA NC_010612.1 2172321 2173070 R function unknown however in M. tuberculosis H37Rv TesA interacts with the PpsE protein. PpsE is part of the phenolphthiocerol synthase PKS cluster; thioesterase TesA complement(2172321..2173070) Mycobacterium marinum M 6226037 YP_001850083.1 CDS MMAR_1779 NC_010612.1 2173067 2173291 R hypothetical protein complement(2173067..2173291) Mycobacterium marinum M 6226038 YP_001850084.1 CDS MMAR_1780 NC_010612.1 2173370 2174113 D function unknown, possibly involved in cell division and chromosome partitioning; hypothetical protein 2173370..2174113 Mycobacterium marinum M 6226039 YP_001850085.1 CDS MMAR_1781 NC_010612.1 2174188 2174781 D hypothetical protein 2174188..2174781 Mycobacterium marinum M 6226040 YP_001850086.1 CDS rnc NC_010612.1 2174784 2175509 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2174784..2175509 Mycobacterium marinum M 6226041 YP_001850087.1 CDS fpg NC_010612.1 2175510 2176388 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 2175510..2176388 Mycobacterium marinum M 6226042 YP_001850088.1 CDS MMAR_1784 NC_010612.1 2176479 2177171 D function unknown. contains N-term OsmC-like protein domain and C-term AcyP, acylphosphatases domain; hypothetical protein 2176479..2177171 Mycobacterium marinum M 6226043 YP_001850089.1 CDS smc NC_010612.1 2177270 2180872 D plays an important role in chromosome structure and partitioning. essential for chromosome partition; chromosome partition protein Smc 2177270..2180872 Mycobacterium marinum M 6226044 YP_001850090.1 CDS ftsY NC_010612.1 2180932 2182308 D probably involved in the reception and insertion of a subset of proteins at the membrane: possibly membrane receptor for Ffh; cell division protein FtsY 2180932..2182308 Mycobacterium marinum M 6226045 YP_001850091.1 CDS amt NC_010612.1 2182452 2183885 D thought to be involved in transport of ammonium across the membrane (export). responsible for the translocation of the substrate across the membrane; ammonium-transport integral membrane protein Amt 2182452..2183885 Mycobacterium marinum M 6226046 YP_001850092.1 CDS glnB NC_010612.1 2183882 2184220 D in nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP by GlnD. P-II-UMP allows the deadenylylation of glutamine synthetase (gs), thus activating the enzyme. converserly, in nitrogen excess P-II is deuridylated and promotes the adenylation of gs. P-II indirectly controls the transcription of the gs gene. P-II prevents NR-II catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. when P-II is uridylylated to P-II-UMP, these events are reversed; nitrogen regulatory protein P-II GlnB 2183882..2184220 Mycobacterium marinum M 6226047 YP_001850093.1 CDS glnD NC_010612.1 2184314 2186752 D catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK; PII uridylyl-transferase 2184314..2186752 Mycobacterium marinum M 6226048 YP_001850094.1 CDS MMAR_1790 NC_010612.1 2186780 2188516 R hypothetical protein complement(2186780..2188516) Mycobacterium marinum M 6226049 YP_001850095.1 CDS MMAR_1791 NC_010612.1 2188732 2188947 R hypothetical protein complement(2188732..2188947) Mycobacterium marinum M 6226050 YP_001850096.1 CDS ffh NC_010612.1 2189086 2190675 D necessary for efficient export of extra-cytoplasmic proteins. binds to the signal sequence when it emerges from the ribosomes; signal recognition particle protein Ffh 2189086..2190675 Mycobacterium marinum M 6226051 YP_001850097.1 CDS MMAR_1793 NC_010612.1 2190682 2191773 D hypothetical protein 2190682..2191773 Mycobacterium marinum M 6226052 YP_001850098.1 CDS pknI NC_010612.1 2191822 2193624 D involved in signal transduction (via phosphorylation). thought to be involved in cell division/differentiation [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 2191822..2193624 Mycobacterium marinum M 6226053 YP_001850099.1 CDS MMAR_1795 NC_010612.1 2193729 2195522 D hydrolizes a specific D-amino acid; D-amino acid aminohydrolase 2193729..2195522 Mycobacterium marinum M 6226054 YP_001850100.1 CDS MMAR_1796 NC_010612.1 2195524 2196126 D thought to be involved in transcriptional mechanism; TetR family transcriptional regulator 2195524..2196126 Mycobacterium marinum M 6226055 YP_001850101.1 CDS dacB NC_010612.1 2196146 2197018 R involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; D-alanyl-D-alanine carboxypeptidase complement(2196146..2197018) Mycobacterium marinum M 6226056 YP_001850102.1 CDS MMAR_1798 NC_010612.1 2197090 2197509 D hypothetical protein 2197090..2197509 Mycobacterium marinum M 6226057 YP_001850103.1 CDS rpsP NC_010612.1 2197715 2198200 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2197715..2198200 Mycobacterium marinum M 6226058 YP_001850104.1 CDS MMAR_1800 NC_010612.1 2198209 2198451 D hypothetical protein 2198209..2198451 Mycobacterium marinum M 6226059 YP_001850105.1 CDS rimM NC_010612.1 2198476 2199000 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2198476..2199000 Mycobacterium marinum M 6226060 YP_001850106.1 CDS trmD NC_010612.1 2199010 2199702 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2199010..2199702 Mycobacterium marinum M 6226061 YP_001850107.1 CDS lppW NC_010612.1 2199814 2200773 R alanine rich lipoprotein LppW complement(2199814..2200773) Mycobacterium marinum M 6226062 YP_001850108.1 CDS rplS NC_010612.1 2201131 2201472 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2201131..2201472 Mycobacterium marinum M 6226063 YP_001850109.1 CDS lepB NC_010612.1 2201584 2202447 D cleavage of N-terminal leader sequences from secreted protein precursors; signal peptidase I LepB 2201584..2202447 Mycobacterium marinum M 6226064 YP_001850110.1 CDS rnhB NC_010612.1 2202450 2203169 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 2202450..2203169 Mycobacterium marinum M 6226065 YP_001850111.1 CDS MMAR_1807 NC_010612.1 2203300 2203605 D hypothetical protein 2203300..2203605 Mycobacterium marinum M 6226066 YP_001850112.1 CDS MMAR_1808 NC_010612.1 2203611 2204396 R hypothetical protein complement(2203611..2204396) Mycobacterium marinum M 6226067 YP_001850113.1 CDS MMAR_1809 NC_010612.1 2204474 2205832 R hypothetical protein complement(2204474..2205832) Mycobacterium marinum M 6226068 YP_001850114.1 CDS galE4 NC_010612.1 2205950 2206930 D contains WcaG, nucleoside-diphosphate-sugar epimerase domain.; function unknown, possibly involved in galactose metabolism; UDP-glucose 4-epimerase 2205950..2206930 Mycobacterium marinum M 6226069 YP_001850115.1 CDS fdhD NC_010612.1 2207065 2207886 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 2207065..2207886 Mycobacterium marinum M 6226070 YP_001850116.1 CDS MMAR_1812 NC_010612.1 2208003 2208371 D hypothetical protein 2208003..2208371 Mycobacterium marinum M 6226071 YP_001850117.1 CDS MMAR_1813 NC_010612.1 2208371 2209882 D hypothetical protein 2208371..2209882 Mycobacterium marinum M 6226072 YP_001850118.1 CDS MMAR_1814 NC_010612.1 2209879 2211054 D hypothetical protein 2209879..2211054 Mycobacterium marinum M 6226073 YP_001850119.1 CDS viuB NC_010612.1 2211087 2211935 D thought to be involved in intracellular removal of iron from iron-mycobactin complex. mycobactin is an iron- chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm; mycobactin utilization protein ViuB 2211087..2211935 Mycobacterium marinum M 6226074 YP_001850120.1 CDS lldD1_1 NC_010612.1 2211959 2213119 D involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]; L-lactate dehydrogenase (cytochrome) LldD1 2211959..2213119 Mycobacterium marinum M 6226075 YP_001850121.1 CDS xerC NC_010612.1 2213151 2214059 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 2213151..2214059 Mycobacterium marinum M 6226076 YP_001850122.1 CDS MMAR_1818 NC_010612.1 2214081 2214587 R hypothetical protein complement(2214081..2214587) Mycobacterium marinum M 6226077 YP_001850123.1 CDS rpsB NC_010612.1 2214892 2215722 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2214892..2215722 Mycobacterium marinum M 6226078 YP_001850124.1 CDS tsf NC_010612.1 2215724 2216539 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2215724..2216539 Mycobacterium marinum M 6226079 YP_001850125.1 CDS amiC NC_010612.1 2216560 2217978 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 2216560..2217978 Mycobacterium marinum M 6226080 YP_001850126.1 CDS MMAR_1822 NC_010612.1 2217994 2218413 R involved in transcriptional mechanism; transcriptional regulatory protein complement(2217994..2218413) Mycobacterium marinum M 6226081 YP_001850127.1 CDS MMAR_1823 NC_010612.1 2218724 2219185 D hypothetical protein 2218724..2219185 Mycobacterium marinum M 6226082 YP_001850128.1 CDS MMAR_1824 NC_010612.1 2219304 2220254 D hypothetical protein 2219304..2220254 Mycobacterium marinum M 6226083 YP_001850129.1 CDS MMAR_1825 NC_010612.1 2220255 2221055 R involved in transcriptional mechanism; transcriptional regulatory protein complement(2220255..2221055) Mycobacterium marinum M 6226084 YP_001850130.1 CDS pyrH NC_010612.1 2221450 2222247 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 2221450..2222247 Mycobacterium marinum M 6226085 YP_001850131.1 CDS frr NC_010612.1 2222312 2222869 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 2222312..2222869 Mycobacterium marinum M 6226086 YP_001850132.1 CDS cdsA NC_010612.1 2222902 2223816 D involved in the phospholipid biosynthesis [catalytic activity: CTP + phosphatidate = pyrophosphate + CDP-diacylglycerol]; integral membrane phosphatidate cytidylyltransferase CdsA 2222902..2223816 Mycobacterium marinum M 6226087 YP_001850133.1 CDS MMAR_1829 NC_010612.1 2224183 2229807 D PE-PGRS family protein 2224183..2229807 Mycobacterium marinum M 6226088 YP_001850134.1 CDS MMAR_1830 NC_010612.1 2229847 2230941 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2229847..2230941 Mycobacterium marinum M 6226089 YP_001850135.1 CDS mpt53 NC_010612.1 2231015 2231536 D despite a weak homology to thioredoxin this cannot serve as a substrate for thioredoxin reductase; furthermore it has no disulfide reducing activity; soluble secreted antigen Mpt53 precursor 2231015..2231536 Mycobacterium marinum M 6226090 YP_001850136.1 CDS MMAR_1832 NC_010612.1 2231550 2232422 D function unknown, possibly involved in transport of mercury across the membrane; integral membrane protein 2231550..2232422 Mycobacterium marinum M 6226091 YP_001850137.1 CDS MMAR_1833 NC_010612.1 2232438 2232860 D hypothetical protein 2232438..2232860 Mycobacterium marinum M 6226092 YP_001850138.1 CDS mpt70 NC_010612.1 2232872 2233465 R major secreted immunogenic protein Mpt70 complement(2232872..2233465) Mycobacterium marinum M 6226093 YP_001850139.1 CDS dipZ NC_010612.1 2233553 2235364 R may be involved in cytochrome-c biogenesis; integral membrane C-type cytochrome biogenesis protein DipZ complement(2233553..2235364) Mycobacterium marinum M 6226094 YP_001850140.1 CDS dxr NC_010612.1 2235392 2236600 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 2235392..2236600 Mycobacterium marinum M 6226095 YP_001850141.1 CDS MMAR_1837 NC_010612.1 2236620 2237834 D transmembrane protein 2236620..2237834 Mycobacterium marinum M 6226096 YP_001850142.1 CDS ispG NC_010612.1 2237857 2239020 D catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2237857..2239020 Mycobacterium marinum M 6226097 YP_001850143.1 CDS MMAR_1839 NC_010612.1 2239072 2239926 D hypothetical protein 2239072..2239926 Mycobacterium marinum M 6226098 YP_001850144.1 CDS MMAR_1840 NC_010612.1 2240037 2241851 D function unknown, possibly involved in cell wall biosynthesis; penicillin-binding lipoprotein 2240037..2241851 Mycobacterium marinum M 6226099 YP_001850145.1 CDS MMAR_1841 NC_010612.1 2241927 2242547 D hypothetical protein 2241927..2242547 Mycobacterium marinum M 6226100 YP_001850146.1 CDS mapB NC_010612.1 2242652 2243509 D removes the amino-terminal methionine from nascent proteins [catalytic activity: L-methionylpeptide + H(2)O = L-methionine + peptide]; methionine aminopeptidase MapB 2242652..2243509 Mycobacterium marinum M 6226101 YP_001850147.1 CDS MMAR_1843 NC_010612.1 2243719 2244270 D hypothetical protein 2243719..2244270 Mycobacterium marinum M 6226102 YP_001850148.1 CDS MMAR_1844 NC_010612.1 2244403 2245140 D function unknown, probably involved in cellular metabolism; amidotransferase 2244403..2245140 Mycobacterium marinum M 6226103 YP_001850149.1 CDS MMAR_1845 NC_010612.1 2245209 2246177 R PPE family protein complement(2245209..2246177) Mycobacterium marinum M 6226104 YP_001850150.1 CDS MMAR_1846 NC_010612.1 2246459 2247007 R hypothetical protein complement(2246459..2247007) Mycobacterium marinum M 6226105 YP_001850151.1 CDS MMAR_1847 NC_010612.1 2247062 2248228 R PPE family protein complement(2247062..2248228) Mycobacterium marinum M 6226106 YP_001850152.1 CDS MMAR_1848 NC_010612.1 2248468 2248899 R hypothetical protein complement(2248468..2248899) Mycobacterium marinum M 6226107 YP_001850153.1 CDS MMAR_1849 NC_010612.1 2249008 2250264 R PPE family protein complement(2249008..2250264) Mycobacterium marinum M 6226108 YP_001850154.1 CDS MMAR_1850 NC_010612.1 2251077 2253656 R PE-PGRS family protein complement(2251077..2253656) Mycobacterium marinum M 6226109 YP_001850155.1 CDS MMAR_1851 NC_010612.1 2253993 2256578 R PE-PGRS family protein complement(2253993..2256578) Mycobacterium marinum M 6226110 YP_001850156.1 CDS bioF2_3 NC_010612.1 2256806 2259250 R could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase complement(2256806..2259250) Mycobacterium marinum M 6226111 YP_001850157.1 CDS MMAR_1853 NC_010612.1 2259311 2259745 R hypothetical protein complement(2259311..2259745) Mycobacterium marinum M 6226112 YP_001850158.1 CDS aroG_1 NC_010612.1 2260030 2261445 R involved in chorismate biosynthesis; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase complement(2260030..2261445) Mycobacterium marinum M 6226113 YP_001850159.1 CDS MMAR_1855 NC_010612.1 2262180 2263292 R hypothetical protein complement(2262180..2263292) Mycobacterium marinum M 6226114 YP_001850160.1 CDS MMAR_1856 NC_010612.1 2263314 2264063 R hypothetical protein complement(2263314..2264063) Mycobacterium marinum M 6226115 YP_001850161.1 CDS hypD NC_010612.1 2264067 2265215 R HypD is involved in hydrogenase formation. it contains many possible metal binding residues, which may bind to nickel; hydrogenase-forming protein, HypD complement(2264067..2265215) Mycobacterium marinum M 6226116 YP_001850162.1 CDS hypC NC_010612.1 2265227 2265499 R chaperone function in the formation of hydrogenase; hydrogenase maturation factor, HypC complement(2265227..2265499) Mycobacterium marinum M 6226117 YP_001850163.1 CDS hypE NC_010612.1 2265522 2266634 R chaperone function in the formation of hydrogenase; hydrogenase maturation factor, HypE complement(2265522..2266634) Mycobacterium marinum M 6226118 YP_001850164.1 CDS MMAR_1860 NC_010612.1 2266631 2267305 R putative sugar phosphate isomerase complement(2266631..2267305) Mycobacterium marinum M 6226119 YP_001850165.1 CDS MMAR_1861 NC_010612.1 2267302 2268024 R hypothetical protein complement(2267302..2268024) Mycobacterium marinum M 6226120 YP_001850166.1 CDS hypF NC_010612.1 2268021 2270411 R HypF participates in the maturation of HupSL and the HupUV proteins; hydrogenase maturation factor, HypF complement(2268021..2270411) Mycobacterium marinum M 6226121 YP_001850167.1 CDS MMAR_1863 NC_010612.1 2270413 2270676 R function unknown chaperone role, possibly in hydrogenase formation; HupF/HypC family protein complement(2270413..2270676) Mycobacterium marinum M 6226122 YP_001850168.1 CDS hyaD NC_010612.1 2270679 2271191 R metal-dependant hydrogenase maturating endopeptidase; nickel/iron hydrogenase maturation factor, HyaD complement(2270679..2271191) Mycobacterium marinum M 6226123 YP_001850169.1 CDS MMAR_1865 NC_010612.1 2271314 2272672 R hypothetical protein complement(2271314..2272672) Mycobacterium marinum M 6226124 YP_001850170.1 CDS MMAR_1866 NC_010612.1 2272669 2273328 R hypothetical protein complement(2272669..2273328) Mycobacterium marinum M 6226125 YP_001850171.1 CDS MMAR_1867 NC_010612.1 2273325 2273951 R hypothetical protein complement(2273325..2273951) Mycobacterium marinum M 6226126 YP_001850172.1 CDS MMAR_1868 NC_010612.1 2273948 2274922 R function unknown, but contains a thioredoxin-like domain; hypothetical protein complement(2273948..2274922) Mycobacterium marinum M 6226127 YP_001850173.1 CDS hyaB NC_010612.1 2274926 2276725 R structural subunit of [nife] hydrogenase; nickel/iron-hydrogenase I large subunit, HyaB complement(2274926..2276725) Mycobacterium marinum M 6226128 YP_001850174.1 CDS hyaA NC_010612.1 2276775 2277830 R small structural subunit for [Ni/Fe] hydrogenase; nickel/iron-hydrogenase I small subunit, HyaA complement(2276775..2277830) Mycobacterium marinum M 6226129 YP_001850175.1 CDS hypB NC_010612.1 2278150 2278917 R involved in regulation of expression and maturation of urease and hydrogenase; nickel cation-binding GTPase, HypB complement(2278150..2278917) Mycobacterium marinum M 6226130 YP_001850176.1 CDS hypA NC_010612.1 2278946 2279338 R involved in hydrogenase synthesis; hydrogenase expression/synthesis protein, HypA complement(2278946..2279338) Mycobacterium marinum M 6226131 YP_001850177.1 CDS hoxN NC_010612.1 2279373 2280491 R involved in nickel transport - part of the hydrogenase operon; high-affinity nickel permease, HoxN complement(2279373..2280491) Mycobacterium marinum M 6226132 YP_001850178.1 CDS MMAR_1874 NC_010612.1 2280642 2281136 D role in the regulation of uptake of iron, zinc and other metals; ferric uptake regulation protein FurB-like protein 2280642..2281136 Mycobacterium marinum M 6226133 YP_001850179.1 CDS mtr NC_010612.1 2281143 2282522 R catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase complement(2281143..2282522) Mycobacterium marinum M 6226134 YP_001850180.1 CDS MMAR_1876 NC_010612.1 2283063 2286119 D lipid metabolism; long-chain acyl-CoA synthetase 2283063..2286119 Mycobacterium marinum M 6226135 YP_001850181.1 CDS mmpL5_1 NC_010612.1 2286106 2289042 R thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(2286106..2289042) Mycobacterium marinum M 6226136 YP_001850182.1 CDS MMAR_1878 NC_010612.1 2289709 2290209 D hypothetical protein 2289709..2290209 Mycobacterium marinum M 6226137 YP_001850183.1 CDS MMAR_1879 NC_010612.1 2290230 2291732 D thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; drug-transport integral membrane protein 2290230..2291732 Mycobacterium marinum M 6226138 YP_001850184.1 CDS MMAR_1880 NC_010612.1 2291709 2292731 R hypothetical protein complement(2291709..2292731) Mycobacterium marinum M 6226139 YP_001850185.1 CDS mqo NC_010612.1 2292928 2294409 D malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2292928..2294409 Mycobacterium marinum M 6226140 YP_001850186.1 CDS elaA NC_010612.1 2294406 2294876 D function unknown, predicted acyltransferase activity; acyltransferase ElaA 2294406..2294876 Mycobacterium marinum M 6226141 YP_001850187.1 CDS MMAR_1883 NC_010612.1 2294873 2296723 D function unknown, possibly introduces a magnesium ion into specific substrate/compound; magnesium chelatase 2294873..2296723 Mycobacterium marinum M 6226142 YP_001850188.1 CDS cobO NC_010612.1 2296745 2297359 D catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 2296745..2297359 Mycobacterium marinum M 6226143 YP_001850189.1 CDS cobB NC_010612.1 2297454 2298830 D responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 2297454..2298830 Mycobacterium marinum M 6226144 YP_001850190.1 CDS cysG NC_010612.1 2298950 2300155 D involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + sirohydrochlorin]. SAM-dependent methyl transferase that methylates uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. it catalyzes also the conversion of precorrin-2 into siroheme (consisting of an oxidation and fe(2+) chelation); multifunctional enzyme siroheme synthase CysG 2298950..2300155 Mycobacterium marinum M 6226145 YP_001850191.1 CDS efpA NC_010612.1 2300189 2301781 D thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane (export): so responsible for the translocation of the substrate across the membrane; integral membrane efflux protein EfpA 2300189..2301781 Mycobacterium marinum M 6226146 YP_001850192.1 CDS proS NC_010612.1 2301888 2303636 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 2301888..2303636 Mycobacterium marinum M 6226147 YP_001850193.1 CDS MMAR_1889 NC_010612.1 2303649 2304137 R hypothetical protein complement(2303649..2304137) Mycobacterium marinum M 6226148 YP_001850194.1 CDS MMAR_1890 NC_010612.1 2304134 2304673 R hypothetical protein complement(2304134..2304673) Mycobacterium marinum M 6226149 YP_001850195.1 CDS MMAR_1891 NC_010612.1 2304889 2305422 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 2304889..2305422 Mycobacterium marinum M 6226150 YP_001850196.1 CDS nusA NC_010612.1 2305419 2306462 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 2305419..2306462 Mycobacterium marinum M 6226151 YP_001850197.1 CDS MMAR_1893 NC_010612.1 2306548 2306928 D hypothetical protein 2306548..2306928 Mycobacterium marinum M 6226152 YP_001850198.1 CDS infB NC_010612.1 2306993 2309836 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 2306993..2309836 Mycobacterium marinum M 6226153 YP_001850199.1 CDS rbfA NC_010612.1 2309849 2310376 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 2309849..2310376 Mycobacterium marinum M 6226154 YP_001850200.1 CDS MMAR_1896 NC_010612.1 2310381 2311355 D hypothetical protein 2310381..2311355 Mycobacterium marinum M 6226155 YP_001850201.1 CDS dinF NC_010612.1 2311371 2312708 D function unknown, induction by DNA damage; DNA-damage-inducible protein F DinF 2311371..2312708 Mycobacterium marinum M 6226156 YP_001850202.1 CDS ugpA NC_010612.1 2312773 2313672 D involved in active transport of SN-glycerol-3- phosphate across the membrane (import). responsible for the translocation of the substrate across the membrane; SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA 2312773..2313672 Mycobacterium marinum M 6226157 YP_001850203.1 CDS ugpE NC_010612.1 2313672 2314514 D involved in active transport of SN-glycerol-3- phosphate across the membrane (import). responsible for the translocation of the substrate across the membrane; SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE 2313672..2314514 Mycobacterium marinum M 6226158 YP_001850204.1 CDS MMAR_1900 NC_010612.1 2314521 2315834 D involved in carbohydrate transport and metabolism; sugar ABC transporter 2314521..2315834 Mycobacterium marinum M 6226159 YP_001850205.1 CDS MMAR_1901 NC_010612.1 2315827 2316909 D thought to be involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system; sugar ABC transporter ATP-binding protein 2315827..2316909 Mycobacterium marinum M 6226160 YP_001850206.1 CDS trxB2_2 NC_010612.1 2316939 2317883 R enzyme that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. in M. tuberculosis it is regulated by SigH. [catalytic activity: NADPH + oxidized thioredoxin = NADP(+) + reduced thioredoxin]; thioredoxin reductase TrxB2 complement(2316939..2317883) Mycobacterium marinum M 6226161 YP_001850207.1 CDS echA16_2 NC_010612.1 2317933 2318682 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2317933..2318682) Mycobacterium marinum M 6226162 YP_001850208.1 CDS MMAR_1904 NC_010612.1 2318976 2320172 D PPE family protein 2318976..2320172 Mycobacterium marinum M 6226163 YP_001850209.1 CDS MMAR_1905 NC_010612.1 2320305 2321480 D PPE family protein 2320305..2321480 Mycobacterium marinum M 6226164 YP_001850210.1 CDS MMAR_1906 NC_010612.1 2321518 2321793 D hypothetical protein 2321518..2321793 Mycobacterium marinum M 6226165 YP_001850211.1 CDS MMAR_1907 NC_010612.1 2321790 2322335 D hypothetical protein 2321790..2322335 Mycobacterium marinum M 6226166 YP_001850212.1 CDS MMAR_1908 NC_010612.1 2322362 2325076 R function unknown but may be involved in trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway). seems to have additional alpha-glucosidase activity; trehalose or maltose hydrolase complement(2322362..2325076) Mycobacterium marinum M 6226167 YP_001850213.1 CDS MMAR_1909 NC_010612.1 2325073 2325672 R hypothetical protein complement(2325073..2325672) Mycobacterium marinum M 6226168 YP_001850214.1 CDS MMAR_1910 NC_010612.1 2325720 2327432 R function unknown, probably involved in cellular metabolism; hydrolase complement(2325720..2327432) Mycobacterium marinum M 6226169 YP_001850215.1 CDS MMAR_1911 NC_010612.1 2327464 2328102 R hypothetical protein complement(2327464..2328102) Mycobacterium marinum M 6226170 YP_001850216.1 CDS MMAR_1912 NC_010612.1 2328233 2328544 D hypothetical protein 2328233..2328544 Mycobacterium marinum M 6226171 YP_001850217.1 CDS MMAR_1913 NC_010612.1 2328535 2330223 D hypothetical protein 2328535..2330223 Mycobacterium marinum M 6226172 YP_001850218.1 CDS lppV_1 NC_010612.1 2330223 2330795 D lipoprotein LppV 2330223..2330795 Mycobacterium marinum M 6226173 YP_001850219.1 CDS MMAR_1915 NC_010612.1 2330886 2331851 D hypothetical protein 2330886..2331851 Mycobacterium marinum M 6226174 YP_001850220.1 CDS pptII NC_010612.1 2331848 2332531 D phosphopantetheinyl transferase. secondary metabolites biosynthesis, transport, and catabolism. Sfp- type phosphopantetheinyl transferase; phosphopantetheinyl transferase, PptII 2331848..2332531 Mycobacterium marinum M 6226175 YP_001850221.1 CDS truB NC_010612.1 2332528 2333433 D catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 2332528..2333433 Mycobacterium marinum M 6226176 YP_001850222.1 CDS ltp1 NC_010612.1 2333540 2334742 D possibly catalyzes the transfer of a great variety of lipids between membranes; lipid-transfer protein 2333540..2334742 Mycobacterium marinum M 6226177 YP_001850223.1 CDS fadE21 NC_010612.1 2334771 2336009 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE21 2334771..2336009 Mycobacterium marinum M 6226178 YP_001850224.1 CDS sirR NC_010612.1 2336026 2336718 R involved in transcriptional mechanism; transcriptional repressor SirR complement(2336026..2336718) Mycobacterium marinum M 6226179 YP_001850225.1 CDS ribF NC_010612.1 2336899 2337873 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 2336899..2337873 Mycobacterium marinum M 6226180 YP_001850226.1 CDS rpsO NC_010612.1 2337999 2338268 D primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 2337999..2338268 Mycobacterium marinum M 6226181 YP_001850227.1 CDS lppU NC_010612.1 2338280 2338813 D lipoprotein LppU 2338280..2338813 Mycobacterium marinum M 6226182 YP_001850228.1 CDS MMAR_1924 NC_010612.1 2338848 2339246 D hypothetical protein 2338848..2339246 Mycobacterium marinum M 6226183 YP_001850229.1 CDS gpsI NC_010612.1 2339617 2341905 D involved in mRNA degradation. hydrolyses single- stranded polyribonucleotides processively in the 3' to 5' direction. involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation [catalytic activity: RNA(n+1) + phosphate = RNA(N) + a nucleoside diphosphate]; polynucleotide phosphorylase/polyadenylase 2339617..2341905 Mycobacterium marinum M 6226184 YP_001850230.1 CDS pepR NC_010612.1 2341883 2343199 D function unknown; possibly hydrolyzes peptides and/or proteins; zinc protease PepR 2341883..2343199 Mycobacterium marinum M 6226185 YP_001850231.1 CDS MMAR_1927 NC_010612.1 2343204 2344238 D hypothetical protein 2343204..2344238 Mycobacterium marinum M 6226186 YP_001850232.1 CDS ald NC_010612.1 2344315 2345430 R may play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [catalytic activity: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3) + NADH]; secreted L-alanine dehydrogenase Ald (40 kDa antigen) complement(2344315..2345430) Mycobacterium marinum M 6226187 YP_001850233.1 CDS MMAR_1929 NC_010612.1 2345626 2346063 D involved in transcriptional mechanism; Lrp/AsnC family transcriptional regulator 2345626..2346063 Mycobacterium marinum M 6226188 YP_001850234.1 CDS MMAR_1930 NC_010612.1 2346092 2346556 D hypothetical protein 2346092..2346556 Mycobacterium marinum M 6226189 YP_001850235.1 CDS MMAR_1931 NC_010612.1 2346661 2347578 D hypothetical protein 2346661..2347578 Mycobacterium marinum M 6226190 YP_001850236.1 CDS ephD_1 NC_010612.1 2347584 2349344 D thought to be involved in detoxification reactions following oxidative damage to lipids; short chain dehydrogenase 2347584..2349344 Mycobacterium marinum M 6226191 YP_001850237.1 CDS MMAR_1933 NC_010612.1 2349358 2350440 D function unknown, probably involved in cellular metabolism; oxidoreductase 2349358..2350440 Mycobacterium marinum M 6226192 YP_001850238.1 CDS MMAR_1934 NC_010612.1 2350446 2351087 R hypothetical protein complement(2350446..2351087) Mycobacterium marinum M 6226193 YP_001850239.1 CDS MMAR_1935 NC_010612.1 2351211 2352236 D function unknown, probably involved in cellular metabolism; oxidoreductase 2351211..2352236 Mycobacterium marinum M 6226194 YP_001850240.1 CDS MMAR_1936 NC_010612.1 2352242 2353330 D hypothetical protein 2352242..2353330 Mycobacterium marinum M 6226195 YP_001850241.1 CDS MMAR_1937 NC_010612.1 2353337 2354674 R hypothetical protein complement(2353337..2354674) Mycobacterium marinum M 6226196 YP_001850242.1 CDS dapB NC_010612.1 2354778 2355515 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 2354778..2355515 Mycobacterium marinum M 6226197 YP_001850243.1 CDS MMAR_1939 NC_010612.1 2355523 2355987 D hypothetical protein 2355523..2355987 Mycobacterium marinum M 6226198 YP_001850244.1 CDS MMAR_1940 NC_010612.1 2355984 2356244 D hypothetical protein 2355984..2356244 Mycobacterium marinum M 6226199 YP_001850245.1 CDS MMAR_1941 NC_010612.1 2356244 2356708 D function unknown, contains a multimeric flavodoxin WrbA domain; hypothetical protein 2356244..2356708 Mycobacterium marinum M 6226200 YP_001850246.1 CDS MMAR_1942 NC_010612.1 2356705 2357718 D hypothetical protein 2356705..2357718 Mycobacterium marinum M 6226201 YP_001850247.1 CDS MMAR_1943 NC_010612.1 2357777 2358646 D hypothetical protein 2357777..2358646 Mycobacterium marinum M 6226202 YP_001850248.1 CDS MMAR_1944 NC_010612.1 2358681 2360135 D hypothetical protein 2358681..2360135 Mycobacterium marinum M 6226203 YP_001850249.1 CDS MMAR_1945 NC_010612.1 2359920 2361683 R function unknown, orthologues in mycobacteriophage; hypothetical protein complement(2359920..2361683) Mycobacterium marinum M 6226204 YP_001850250.1 CDS MMAR_1946 NC_010612.1 2361752 2362234 D dehydrogenase 2361752..2362234 Mycobacterium marinum M 6226205 YP_001850251.1 CDS MMAR_1947 NC_010612.1 2362393 2363526 D function unknown. may be involved in virulence; PPE family protein 2362393..2363526 Mycobacterium marinum M 6226206 YP_001850252.1 CDS fadD13_1 NC_010612.1 2363626 2365173 D function unknown, but involved in lipid degradation; fatty acid-CoA ligase FadD13 2363626..2365173 Mycobacterium marinum M 6226207 YP_001850253.1 CDS MMAR_1949 NC_010612.1 2365472 2366275 D PE family protein 2365472..2366275 Mycobacterium marinum M 6226208 YP_001850254.1 CDS MMAR_1950 NC_010612.1 2366345 2367526 D PPE family protein 2366345..2367526 Mycobacterium marinum M 6226209 YP_001850255.1 CDS accA3_1 NC_010612.1 2367558 2370791 D involved in long-chain fatty acid synthesis (at the first step). carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein]; bifunctional protein acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA3 2367558..2370791 Mycobacterium marinum M 6226210 YP_001850256.1 CDS MMAR_5563 NC_010612.1 2370808 2371158 R PE-PGRS family protein complement(2370808..2371158) Mycobacterium marinum M 6226211 YP_001850257.1 CDS fabG NC_010612.1 2371280 2372062 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 2371280..2372062 Mycobacterium marinum M 6226212 YP_001850258.1 CDS fadE34_1 NC_010612.1 2372059 2373252 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE34 2372059..2373252 Mycobacterium marinum M 6226213 YP_001850259.1 CDS fadE18_1 NC_010612.1 2373249 2374352 D function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase FadE18 2373249..2374352 Mycobacterium marinum M 6226214 YP_001850260.1 CDS MMAR_1955 NC_010612.1 2374375 2375115 R function unknown, probably involved in cellular metabolism; alanine rich hydrolase complement(2374375..2375115) Mycobacterium marinum M 6226215 YP_001850261.1 CDS thyA NC_010612.1 2375214 2376014 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 2375214..2376014 Mycobacterium marinum M 6226216 YP_001850262.1 CDS dfrA NC_010612.1 2376022 2376519 D essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dump to dTMP [catalytic activity: 5,6,7,8- tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH]; dihydrofolate reductase DfrA 2376022..2376519 Mycobacterium marinum M 6226217 YP_001850263.1 CDS MMAR_1958 NC_010612.1 2376516 2377730 D hypothetical protein 2376516..2377730 Mycobacterium marinum M 6226218 YP_001850264.1 CDS hsdM NC_010612.1 2377730 2379184 D implicated in methylation of DNA. component of type I restriction/modification system. it is possible that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence; type I restriction/modification system DNA methylase HsdM 2377730..2379184 Mycobacterium marinum M 6226219 YP_001850265.1 CDS hsdS NC_010612.1 2379181 2380266 D implicated in restriction/modification of DNA. component of type I restriction/modification system. it is thought that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence; type I restriction/modification system specificity determinant HsdS (S protein) 2379181..2380266 Mycobacterium marinum M 6226220 YP_001850266.1 CDS thyX NC_010612.1 2380277 2381029 D flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 2380277..2381029 Mycobacterium marinum M 6226221 YP_001850267.1 CDS dapA NC_010612.1 2381147 2382049 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2381147..2382049 Mycobacterium marinum M 6226222 YP_001850268.1 CDS MMAR_1963 NC_010612.1 2382069 2383745 D function unknown, belongs to the metallo-beta- lactamase superfamily; hydrolase 2382069..2383745 Mycobacterium marinum M 6226223 YP_001850269.1 CDS MMAR_1964 NC_010612.1 2383769 2384641 R function unknown domain identity suggests this is a methylase involved in secondary metabolism (polyketides); O-methyltransferase complement(2383769..2384641) Mycobacterium marinum M 6226224 YP_001850270.1 CDS fabG NC_010612.1 2384645 2385478 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(2384645..2385478) Mycobacterium marinum M 6226225 YP_001850271.1 CDS MMAR_1966 NC_010612.1 2385478 2385789 R hypothetical protein complement(2385478..2385789) Mycobacterium marinum M 6226226 YP_001850272.1 CDS ftsK NC_010612.1 2385969 2388578 D possibly involved in cell division processes; cell division transmembrane protein FtsK 2385969..2388578 Mycobacterium marinum M 6226227 YP_001850273.1 CDS MMAR_1968 NC_010612.1 2388590 2389114 R catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase complement(2388590..2389114) Mycobacterium marinum M 6226228 YP_001850274.1 CDS pgsA3 NC_010612.1 2389199 2389768 D involved in acidic phospholipid biosynthesis. this protein probably catalyzes the committed step to the synthesis of the acidic phospholipids [catalytic activity: CDP-diacylglycerol + glycerol-3-phosphate = CMP + 3-(3- phosphatidyl)-glycerol 1-phosphate]; PGP synthase PgsA3 2389199..2389768 Mycobacterium marinum M 6226229 YP_001850275.1 CDS MMAR_1970 NC_010612.1 2389908 2390234 D possibly involved in transcriptional mechanism; transcriptional regulatory protein 2389908..2390234 Mycobacterium marinum M 6226230 YP_001850276.1 CDS MMAR_1971 NC_010612.1 2390393 2391208 D function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription; hypothetical protein 2390393..2391208 Mycobacterium marinum M 6226231 YP_001850277.1 CDS MMAR_1972 NC_010612.1 2391224 2392039 D hypothetical protein 2391224..2392039 Mycobacterium marinum M 6226232 YP_001850278.1 CDS MMAR_1973 NC_010612.1 2392048 2392488 R function unknown but contains a lima, limonene-1,2- epoxide hydrolase domain; hypothetical protein complement(2392048..2392488) Mycobacterium marinum M 6226233 YP_001850279.1 CDS MMAR_1974 NC_010612.1 2392584 2393750 D function unknown, probably involved in cellular metabolism; glycosyl transferase family protein 2392584..2393750 Mycobacterium marinum M 6226234 YP_001850280.1 CDS MMAR_1975 NC_010612.1 2393774 2393980 D hypothetical protein 2393774..2393980 Mycobacterium marinum M 6226235 YP_001850281.1 CDS MMAR_1976 NC_010612.1 2393993 2394718 R hypothetical protein complement(2393993..2394718) Mycobacterium marinum M 6226236 YP_001850282.1 CDS recA NC_010612.1 2394811 2395851 D catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2394811..2395851 Mycobacterium marinum M 6226237 YP_001850283.1 CDS recX NC_010612.1 2395817 2396338 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2395817..2396338 Mycobacterium marinum M 6226238 YP_001850284.1 CDS MMAR_1979 NC_010612.1 2396413 2398011 D catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 2396413..2398011 Mycobacterium marinum M 6226239 YP_001850285.1 CDS MMAR_1980 NC_010612.1 2398008 2398619 D hypothetical protein 2398008..2398619 Mycobacterium marinum M 6226240 YP_001850286.1 CDS MMAR_1981 NC_010612.1 2398616 2399965 R hypothetical protein complement(2398616..2399965) Mycobacterium marinum M 6226241 YP_001850287.1 CDS pknH_2 NC_010612.1 2400206 2402011 R involved in signal transduction (via phosphorylation). thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase complement(2400206..2402011) Mycobacterium marinum M 6226242 YP_001850288.1 CDS MMAR_1983 NC_010612.1 2402475 2403374 D hypothetical protein 2402475..2403374 Mycobacterium marinum M 6226243 YP_001850289.1 CDS MMAR_1984 NC_010612.1 2403594 2404571 D hypothetical protein 2403594..2404571 Mycobacterium marinum M 6226244 YP_001850290.1 CDS MMAR_1985 NC_010612.1 2404618 2405313 D hypothetical protein 2404618..2405313 Mycobacterium marinum M 6226245 YP_001850291.1 CDS miaA NC_010612.1 2405310 2406254 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 2405310..2406254 Mycobacterium marinum M 6226246 YP_001850292.1 CDS dapF NC_010612.1 2406259 2407131 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 2406259..2407131 Mycobacterium marinum M 6226247 YP_001850293.1 CDS hflX NC_010612.1 2407178 2408692 D possibly a GTPase, modulating activity of HflK and HflC proteins; GTP-binding protein HflX 2407178..2408692 Mycobacterium marinum M 6226248 YP_001850294.1 CDS fadE20 NC_010612.1 2408836 2409996 D function unknown, but involved in lipid metabolism; acyl-CoA dehydrogenase FadE20 2408836..2409996 Mycobacterium marinum M 6226249 YP_001850295.1 CDS MMAR_1990 NC_010612.1 2410025 2411206 R hypothetical protein complement(2410025..2411206) Mycobacterium marinum M 6226250 YP_001850296.1 CDS MMAR_1991 NC_010612.1 2411501 2413801 D hypothetical protein 2411501..2413801 Mycobacterium marinum M 6226251 YP_001850297.1 CDS lexA NC_010612.1 2413842 2414576 R Represses a number of genes involved in the response to DNA damage; LexA repressor complement(2413842..2414576) Mycobacterium marinum M 6226252 YP_001850298.1 CDS MMAR_1993 NC_010612.1 2414884 2415426 D in M. tuberculosis H37Rv thought to be regulated by LexA; hypothetical protein 2414884..2415426 Mycobacterium marinum M 6226253 YP_001850299.1 CDS MMAR_1994 NC_010612.1 2415436 2416053 D membrane-associated regulatory protein 2415436..2416053 Mycobacterium marinum M 6226254 YP_001850300.1 CDS MMAR_1995 NC_010612.1 2416082 2416567 D hypothetical protein 2416082..2416567 Mycobacterium marinum M 6226255 YP_001850301.1 CDS MMAR_1996 NC_010612.1 2416577 2417263 R function unknown but contains identity to an epimerase involved in phenazine biosynthesis; hypothetical protein complement(2416577..2417263) Mycobacterium marinum M 6226256 YP_001850302.1 CDS MMAR_1997 NC_010612.1 2417309 2418334 R function unknown, probably involved in cellular metabolism; hydrolase complement(2417309..2418334) Mycobacterium marinum M 6226257 YP_001850303.1 CDS MMAR_1998 NC_010612.1 2418383 2419360 R hypothetical protein complement(2418383..2419360) Mycobacterium marinum M 6226258 YP_001850304.1 CDS MMAR_1999 NC_010612.1 2419604 2420431 D function unknown but contains weak similarity to V8- like Glu-specific endopeptidases involved in amino acid transport and metabolism; hypothetical protein 2419604..2420431 Mycobacterium marinum M 6226259 YP_001850305.1 CDS sthA NC_010612.1 2420439 2421854 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(2420439..2421854) Mycobacterium marinum M 6226260 YP_001850306.1 CDS MMAR_2001 NC_010612.1 2421960 2423027 D hypothetical protein 2421960..2423027 Mycobacterium marinum M 6226261 YP_001850307.1 CDS ideR NC_010612.1 2423029 2423721 R transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene; iron-dependent repressor and activator IdeR complement(2423029..2423721) Mycobacterium marinum M 6226262 YP_001850308.1 CDS sigB NC_010612.1 2423873 2424874 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB complement(2423873..2424874) Mycobacterium marinum M 6226263 YP_001850309.1 CDS MMAR_2004 NC_010612.1 2425009 2425419 R hypothetical protein complement(2425009..2425419) Mycobacterium marinum M 6226264 YP_001850310.1 CDS MMAR_2005 NC_010612.1 2425474 2425722 D hypothetical protein 2425474..2425722 Mycobacterium marinum M 6226265 YP_001850311.1 CDS MMAR_2006 NC_010612.1 2425723 2426697 R hypothetical protein complement(2425723..2426697) Mycobacterium marinum M 6226266 YP_001850312.1 CDS MMAR_2007 NC_010612.1 2426763 2426948 R hypothetical protein complement(2426763..2426948) Mycobacterium marinum M 6226267 YP_001850313.1 CDS MMAR_2008 NC_010612.1 2427075 2427455 D hypothetical protein 2427075..2427455 Mycobacterium marinum M 6226268 YP_001850314.1 CDS MMAR_2009 NC_010612.1 2427383 2427826 R function unknown but contains pfam01042 domain, endoribonuclease L-PSP. endoribonuclease active on single- stranded mRNA. inhibits protein synthesis by cleavage of mRNA. previously thought to inhibit protein synthesis initiation. this protein may also be involved I; hypothetical protein complement(2427383..2427826) Mycobacterium marinum M 6226269 YP_001850315.1 CDS MMAR_2010 NC_010612.1 2427932 2429896 R PE-PGRS family protein complement(2427932..2429896) Mycobacterium marinum M 6226270 YP_001850316.1 CDS sigA NC_010612.1 2430106 2431611 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor complement(2430106..2431611) Mycobacterium marinum M 6226271 YP_001850317.1 CDS ppgK NC_010612.1 2431790 2432584 R catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. GTP, UTP and CTP can replace ATP as phosphoryl donor [catalytic activity: (phosphate)(N) + d-glucose = (phosphate)(N-1) + d-glucose 6-phosphate]; polyphosphate glucokinase PpgK complement(2431790..2432584) Mycobacterium marinum M 6226272 YP_001850318.1 CDS suhB NC_010612.1 2432706 2433575 D in E. coli, SuhB mutation (SuhB2) enhances the synthesis of sigma(32) and suppresses temperature- sensitive growth of the RpoH15 mutant. may affect some step(S) of protein synthesis by facilitating the function of GroE or other heat shock proteins; extragenic suppressor protein SuhB 2432706..2433575 Mycobacterium marinum M 6226273 YP_001850319.1 CDS MMAR_2014 NC_010612.1 2433581 2434234 R hypothetical protein complement(2433581..2434234) Mycobacterium marinum M 6226274 YP_001850320.1 CDS MMAR_2015 NC_010612.1 2434418 2434720 D hypothetical protein 2434418..2434720 Mycobacterium marinum M 6226275 YP_001850321.1 CDS MMAR_2016 NC_010612.1 2434725 2435204 R hypothetical protein complement(2434725..2435204) Mycobacterium marinum M 6226276 YP_001850322.1 CDS dut NC_010612.1 2435230 2435694 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 2435230..2435694 Mycobacterium marinum M 6226277 YP_001850323.1 CDS MMAR_2018 NC_010612.1 2435694 2436437 D hypothetical protein 2435694..2436437 Mycobacterium marinum M 6226278 YP_001850324.1 CDS MMAR_2019 NC_010612.1 2436451 2437170 R hypothetical protein complement(2436451..2437170) Mycobacterium marinum M 6226279 YP_001850325.1 CDS MMAR_2020 NC_010612.1 2437302 2437685 D hypothetical protein 2437302..2437685 Mycobacterium marinum M 6226280 YP_001850326.1 CDS MMAR_2021 NC_010612.1 2437713 2438384 D integral membrane alanine and leucine rich protein 2437713..2438384 Mycobacterium marinum M 6226281 YP_001850327.1 CDS ceoC NC_010612.1 2438603 2439265 R part of a potassium transport system; TRK system potassium uptake protein CeoC complement(2438603..2439265) Mycobacterium marinum M 6226282 YP_001850328.1 CDS ceoB NC_010612.1 2439318 2440001 R part of a potassium transport system; TRK system potassium uptake protein CeoB complement(2439318..2440001) Mycobacterium marinum M 6226283 YP_001850329.1 CDS MMAR_2024 NC_010612.1 2440134 2442131 D function unknown but domain identity suggests a role in amino acid transport; integral membrane alanine, valine and leucine rich protein 2440134..2442131 Mycobacterium marinum M 6226284 YP_001850330.1 CDS MMAR_2025 NC_010612.1 2442128 2443333 D function unknown but domain identity suggests this CDS encodes TrmA, a protein related to tRNA (uracil-5-)- methyltransferases; SAM-dependent methyltransferase 2442128..2443333 Mycobacterium marinum M 6226285 YP_001850331.1 CDS MMAR_2026 NC_010612.1 2443458 2444357 D thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system; antibiotic-transport ATP-binding protein ABC transporter 2443458..2444357 Mycobacterium marinum M 6226286 YP_001850332.1 CDS MMAR_2027 NC_010612.1 2444354 2445064 D thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; antibiotic ABC transporter integral membrane protein 2444354..2445064 Mycobacterium marinum M 6226287 YP_001850333.1 CDS MMAR_2028 NC_010612.1 2445061 2445825 D thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; antibiotic ABC transporter integral membrane protein 2445061..2445825 Mycobacterium marinum M 6226288 YP_001850334.1 CDS arsB1 NC_010612.1 2445831 2447117 R thought to be involved in transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; arsenic-transport integral membrane protein ArsB1 complement(2445831..2447117) Mycobacterium marinum M 6226289 YP_001850335.1 CDS arsA NC_010612.1 2447156 2448445 R thought to be involved in active transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; arsenic-transport integral membrane protein ArsA complement(2447156..2448445) Mycobacterium marinum M 6226290 YP_001850336.1 CDS MMAR_2031 NC_010612.1 2448501 2448944 R hypothetical protein complement(2448501..2448944) Mycobacterium marinum M 6226291 YP_001850337.1 CDS dxs1 NC_010612.1 2449148 2451061 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 2449148..2451061 Mycobacterium marinum M 6226292 YP_001850338.1 CDS MMAR_2033 NC_010612.1 2451104 2454973 R PE-PGRS family protein complement(2451104..2454973) Mycobacterium marinum M 6226293 YP_001850339.1 CDS MMAR_2035 NC_010612.1 2456511 2457818 R hypothetical protein complement(2456511..2457818) Mycobacterium marinum M 6226295 YP_001850340.1 CDS MMAR_2036 NC_010612.1 2457820 2458401 R hypothetical protein complement(2457820..2458401) Mycobacterium marinum M 6226296 YP_001850341.1 CDS echA15 NC_010612.1 2458540 2459349 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2458540..2459349) Mycobacterium marinum M 6226297 YP_001850342.1 CDS hemE NC_010612.1 2459472 2460533 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 2459472..2460533 Mycobacterium marinum M 6226298 YP_001850343.1 CDS hemY NC_010612.1 2460530 2461897 D catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 2460530..2461897 Mycobacterium marinum M 6226299 YP_001850344.1 CDS MMAR_2040 NC_010612.1 2461903 2462598 D function unknown but contains identity to pfam06778, chlorite dismutase. this family contains chlorite dismutase enzymes of bacterial and archaeal origin. this enzyme catalyses the disproportionation of chlorite into chloride and oxygen. note that many family memb; hypothetical protein 2461903..2462598 Mycobacterium marinum M 6226300 YP_001850345.1 CDS MMAR_2041 NC_010612.1 2462595 2463344 D methyltransferase 2462595..2463344 Mycobacterium marinum M 6226301 YP_001850346.1 CDS MMAR_2042 NC_010612.1 2463351 2463791 R function unknown but contains a SelR domain. these family of reductases are involved in the reduction of methionine sulfoxides in proteins; hypothetical protein complement(2463351..2463791) Mycobacterium marinum M 6226302 YP_001850347.1 CDS MMAR_2043 NC_010612.1 2463788 2465098 R transmembrane protein complement(2463788..2465098) Mycobacterium marinum M 6226303 YP_001850348.1 CDS MMAR_2044 NC_010612.1 2465118 2466689 R hypothetical protein complement(2465118..2466689) Mycobacterium marinum M 6226304 YP_001850349.1 CDS ribD NC_010612.1 2466738 2467520 R involved in riboflavin biosynthesis (at the second and third steps). converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH]; hypothetical protein complement(2466738..2467520) Mycobacterium marinum M 6226305 YP_001850350.1 CDS MMAR_2046 NC_010612.1 2467578 2468654 D hypothetical protein 2467578..2468654 Mycobacterium marinum M 6226306 YP_001850351.1 CDS MMAR_5575 NC_010612.1 2468632 2469090 R hypothetical protein complement(2468632..2469090) Mycobacterium marinum M 6226307 YP_001850352.1 CDS MMAR_2047 NC_010612.1 2469137 2469697 R hypothetical protein complement(2469137..2469697) Mycobacterium marinum M 6226308 YP_001850353.1 CDS clpC2 NC_010612.1 2469776 2470519 R function unknown, possibly hydrolyzes peptides and/or proteins in presence of ATP; ATP-dependent protease ATP-binding subunit ClpC2 complement(2469776..2470519) Mycobacterium marinum M 6226309 YP_001850354.1 CDS MMAR_2049 NC_010612.1 2470627 2470950 D hypothetical protein 2470627..2470950 Mycobacterium marinum M 6226310 YP_001850355.1 CDS MMAR_2050 NC_010612.1 2471004 2471963 D function unknown but has domain identity with lysophospholipases; hypothetical protein 2471004..2471963 Mycobacterium marinum M 6226311 YP_001850356.1 CDS MMAR_2051 NC_010612.1 2471995 2473662 D hypothetical protein 2471995..2473662 Mycobacterium marinum M 6226312 YP_001850357.1 CDS MMAR_2052 NC_010612.1 2473640 2475040 R thought to be involved in transport of amino acid across the membrane; amino acid transporter complement(2473640..2475040) Mycobacterium marinum M 6226313 YP_001850358.1 CDS MMAR_2053 NC_010612.1 2475782 2477995 R PE-PGRS family protein complement(2475782..2477995) Mycobacterium marinum M 6226318 YP_001850359.1 CDS MMAR_2054 NC_010612.1 2478535 2479350 R hypothetical protein complement(2478535..2479350) Mycobacterium marinum M 6226319 YP_001850360.1 CDS arsC NC_010612.1 2479478 2480995 R involved in transport of arsenic compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; arsenic-transport integral membrane protein ArsC complement(2479478..2480995) Mycobacterium marinum M 6226320 YP_001850361.1 CDS MMAR_2056 NC_010612.1 2480992 2481369 R involved in transcriptional mechanism; ArsR family transcriptional regulator complement(2480992..2481369) Mycobacterium marinum M 6226321 YP_001850362.1 CDS cadI NC_010612.1 2481449 2481919 R function unknown, in M. tuberculosis H37Rv this gene induced by cadmium (see hotter et al., 2001); hypothetical protein complement(2481449..2481919) Mycobacterium marinum M 6226322 YP_001850363.1 CDS MMAR_2058 NC_010612.1 2482021 2482380 D involved in transcriptional mechanism; ArsR family transcriptional regulator 2482021..2482380 Mycobacterium marinum M 6226323 YP_001850364.1 CDS MMAR_2059 NC_010612.1 2482478 2482768 D hypothetical protein 2482478..2482768 Mycobacterium marinum M 6226324 YP_001850365.1 CDS MMAR_2060 NC_010612.1 2482811 2483758 D it catalyses the conversion of hydrogen peroxide to water and molecular oxygen and is thus involved in the protection of cells from the toxic effects of peroxides; catalase 2482811..2483758 Mycobacterium marinum M 6226325 YP_001850366.1 CDS MMAR_2061 NC_010612.1 2483778 2484218 R function unknown but contains identity with a pfam01740 STAS domain. the STAS (after sulphate transporter and antisigma factor antagonist) domain is found in the C terminal region of sulphate transporters and bacterial antisigma factor antagonists. it has been Sug; hypothetical protein complement(2483778..2484218) Mycobacterium marinum M 6226326 YP_001850367.1 CDS MMAR_2062 NC_010612.1 2484371 2484976 D hypothetical protein 2484371..2484976 Mycobacterium marinum M 6226327 YP_001850368.1 CDS dedA NC_010612.1 2484987 2485643 R transmembrane protein DedA complement(2484987..2485643) Mycobacterium marinum M 6226328 YP_001850369.1 CDS MMAR_2064 NC_010612.1 2485875 2487512 D function unknown, but involved in lipid degradation; fatty-acid-CoA ligase 2485875..2487512 Mycobacterium marinum M 6226329 YP_001850370.1 CDS MMAR_2065 NC_010612.1 2487522 2488151 R role in resistance to chloramphenicol. modifies the primary (C-3) hydroxyl of the antibiotic; chloramphenicol 3-O-phosphotransferase complement(2487522..2488151) Mycobacterium marinum M 6226330 YP_001850371.1 CDS MMAR_2066 NC_010612.1 2488603 2489106 R hypothetical protein complement(2488603..2489106) Mycobacterium marinum M 6226331 YP_001850372.1 CDS MMAR_2067 NC_010612.1 2489762 2492080 D PE-PGRS family protein 2489762..2492080 Mycobacterium marinum M 6226332 YP_001850373.1 CDS MMAR_2068 NC_010612.1 2492181 2492462 D hypothetical protein 2492181..2492462 Mycobacterium marinum M 6226333 YP_001850374.1 CDS MMAR_2069 NC_010612.1 2492496 2493806 R function unknown but contains phosphoribosyltransferase domain; hypothetical protein complement(2492496..2493806) Mycobacterium marinum M 6226334 YP_001850375.1 CDS MMAR_2070 NC_010612.1 2493906 2495030 R hypothetical protein complement(2493906..2495030) Mycobacterium marinum M 6226335 YP_001850376.1 CDS fadD11_1 NC_010612.1 2495093 2496958 R involved in lipid metabolism; long-chain-fatty-acid-CoA ligase, FadD11 complement(2495093..2496958) Mycobacterium marinum M 6226336 YP_001850377.1 CDS MMAR_2072 NC_010612.1 2497213 2498466 D hypothetical protein 2497213..2498466 Mycobacterium marinum M 6226337 YP_001850378.1 CDS MMAR_2073 NC_010612.1 2498482 2499909 D hypothetical protein 2498482..2499909 Mycobacterium marinum M 6226338 YP_001850379.1 CDS MMAR_2074 NC_010612.1 2499913 2500647 D hypothetical protein 2499913..2500647 Mycobacterium marinum M 6226339 YP_001850380.1 CDS MMAR_2075 NC_010612.1 2500683 2501915 D hypothetical protein 2500683..2501915 Mycobacterium marinum M 6226340 YP_001850381.1 CDS MMAR_2076 NC_010612.1 2501969 2502763 D hypothetical protein 2501969..2502763 Mycobacterium marinum M 6226341 YP_001850382.1 CDS MMAR_2077 NC_010612.1 2502760 2503653 R hypothetical protein complement(2502760..2503653) Mycobacterium marinum M 6226342 YP_001850383.1 CDS MMAR_2078 NC_010612.1 2503783 2504607 R methylation of unknown substrate; methyltransferase complement(2503783..2504607) Mycobacterium marinum M 6226343 YP_001850384.1 CDS narK3 NC_010612.1 2504797 2506215 R involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK3 complement(2504797..2506215) Mycobacterium marinum M 6226344 YP_001850385.1 CDS fdxA_1 NC_010612.1 2506383 2506730 D involved in electron transfer; ferredoxin FdxA 2506383..2506730 Mycobacterium marinum M 6226345 YP_001850386.1 CDS MMAR_2081 NC_010612.1 2506740 2507411 D transcriptional regulator 2506740..2507411 Mycobacterium marinum M 6226346 YP_001850387.1 CDS MMAR_2082 NC_010612.1 2507408 2507833 D hypothetical protein 2507408..2507833 Mycobacterium marinum M 6226347 YP_001850388.1 CDS MMAR_2083 NC_010612.1 2507846 2508190 D hypothetical protein 2507846..2508190 Mycobacterium marinum M 6226348 YP_001850389.1 CDS MMAR_2084 NC_010612.1 2508193 2509137 D function unknown but contains pfam03060 domain, NPD, 2-nitropropane dioxygenase. members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor; hypothetical protein 2508193..2509137 Mycobacterium marinum M 6226349 YP_001850390.1 CDS MMAR_2085 NC_010612.1 2509170 2509673 R hypothetical protein complement(2509170..2509673) Mycobacterium marinum M 6226350 YP_001850391.1 CDS MMAR_2086 NC_010612.1 2509753 2510613 D oxidoreductase 2509753..2510613 Mycobacterium marinum M 6226351 YP_001850392.1 CDS MMAR_2087 NC_010612.1 2510700 2511323 D hypothetical protein 2510700..2511323 Mycobacterium marinum M 6226352 YP_001850393.1 CDS thrS NC_010612.1 2511451 2513526 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 2511451..2513526 Mycobacterium marinum M 6226353 YP_001850394.1 CDS MMAR_2089 NC_010612.1 2513529 2514101 D function unknown, but location and domain identity to hydrlases suggests it could be involved in lipid metabolism; hypothetical protein 2513529..2514101 Mycobacterium marinum M 6226354 YP_001850395.1 CDS pgsA1 NC_010612.1 2514109 2514813 D catalyzes the transfer of a free alcohol (inositol) onto CDP-diacylglycerol. the product of this putative ORF seems be essential to mycobacteria [catalytic activity: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl 1D- myo-inositol]; pi synthase PgsA1 2514109..2514813 Mycobacterium marinum M 6226355 YP_001850396.1 CDS MMAR_2091 NC_010612.1 2514810 2515760 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2514810..2515760 Mycobacterium marinum M 6226356 YP_001850397.1 CDS pimA NC_010612.1 2515760 2516884 D involved in the first mannosylation step in phosphatidylinositol mannoside biosynthesis (transfer of mannose residues onto pi, leading to the synthesis of phosphatidylinositol monomannoside); alpha-mannosyltransferase PimA 2515760..2516884 Mycobacterium marinum M 6226357 YP_001850398.1 CDS MMAR_2093 NC_010612.1 2516884 2517951 D function unknown but contains a NUDIX domain; hypothetical protein 2516884..2517951 Mycobacterium marinum M 6226358 YP_001850399.1 CDS snzP NC_010612.1 2518143 2518991 D with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 2518143..2518991 Mycobacterium marinum M 6226359 YP_001850400.1 CDS tesB2 NC_010612.1 2519001 2519846 D function unknown, lipolytic enzyme involved in cellular metabolism. can hydrolyze a broad range of acyl- CoA thioesters; acyl-CoA thioesterase II TesB2 2519001..2519846 Mycobacterium marinum M 6226360 YP_001850401.1 CDS snoP NC_010612.1 2519854 2520450 D with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 2519854..2520450 Mycobacterium marinum M 6226361 YP_001850402.1 CDS MMAR_2097 NC_010612.1 2520477 2522264 R function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein complement(2520477..2522264) Mycobacterium marinum M 6226362 YP_001850403.1 CDS MMAR_2098 NC_010612.1 2522539 2523294 D highly conserved protein; hypothetical protein 2522539..2523294 Mycobacterium marinum M 6226363 YP_001850404.1 CDS MMAR_2099 NC_010612.1 2523310 2524527 R transcriptional regulator complement(2523310..2524527) Mycobacterium marinum M 6226364 YP_001850405.1 CDS MMAR_2100 NC_010612.1 2524988 2529181 D PE-PGRS family protein 2524988..2529181 Mycobacterium marinum M 6226365 YP_001850406.1 CDS MMAR_2101 NC_010612.1 2529363 2529860 D hypothetical protein 2529363..2529860 Mycobacterium marinum M 6226366 YP_001850407.1 CDS MMAR_2102 NC_010612.1 2530065 2534225 D PE-PGRS family protein 2530065..2534225 Mycobacterium marinum M 6226367 YP_001850408.1 CDS MMAR_2103 NC_010612.1 2534389 2536353 D PE-PGRS family protein 2534389..2536353 Mycobacterium marinum M 6226368 YP_001850409.1 CDS speE NC_010612.1 2536366 2537946 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(2536366..2537946) Mycobacterium marinum M 6226369 YP_001850410.1 CDS MMAR_2105 NC_010612.1 2537943 2538413 R hypothetical protein complement(2537943..2538413) Mycobacterium marinum M 6226370 YP_001850411.1 CDS MMAR_2106 NC_010612.1 2538447 2538878 R function unknown, possible membrane protein; hypothetical protein complement(2538447..2538878) Mycobacterium marinum M 6226371 YP_001850412.1 CDS MMAR_2107 NC_010612.1 2538875 2539387 R hypothetical protein complement(2538875..2539387) Mycobacterium marinum M 6226372 YP_001850413.1 CDS MMAR_2108 NC_010612.1 2539397 2540005 R hypothetical protein complement(2539397..2540005) Mycobacterium marinum M 6226373 YP_001850414.1 CDS ruvC NC_010612.1 2540220 2540774 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2540220..2540774 Mycobacterium marinum M 6226374 YP_001850415.1 CDS ruvA NC_010612.1 2540771 2541364 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2540771..2541364 Mycobacterium marinum M 6226375 YP_001850416.1 CDS ruvB NC_010612.1 2541368 2542405 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2541368..2542405 Mycobacterium marinum M 6226376 YP_001850417.1 CDS MMAR_2112 NC_010612.1 2542431 2544164 R PE-PGRS family protein complement(2542431..2544164) Mycobacterium marinum M 6226377 YP_001850418.1 CDS MMAR_2113 NC_010612.1 2544385 2546025 R PE-PGRS family protein complement(2544385..2546025) Mycobacterium marinum M 6226378 YP_001850419.1 CDS MMAR_2114 NC_010612.1 2546220 2546606 D function unknown, domain identity membrane protein Cdd COG3759; hypothetical protein 2546220..2546606 Mycobacterium marinum M 6226379 YP_001850420.1 CDS MMAR_2115 NC_010612.1 2546696 2547388 D hypothetical protein 2546696..2547388 Mycobacterium marinum M 6226380 YP_001850421.1 CDS MMAR_2116 NC_010612.1 2547426 2549558 R PE-PGRS family protein complement(2547426..2549558) Mycobacterium marinum M 6226381 YP_001850422.1 CDS fadD9 NC_010612.1 2549712 2553236 R function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD9 complement(2549712..2553236) Mycobacterium marinum M 6226382 YP_001850423.1 CDS gabT NC_010612.1 2553417 2554757 R catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase complement(2553417..2554757) Mycobacterium marinum M 6226383 YP_001850424.1 CDS yajC NC_010612.1 2554987 2555328 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 2554987..2555328 Mycobacterium marinum M 6226384 YP_001850425.1 CDS secD NC_010612.1 2555440 2557287 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 2555440..2557287 Mycobacterium marinum M 6226385 YP_001850426.1 CDS secF NC_010612.1 2557292 2558632 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 2557292..2558632 Mycobacterium marinum M 6226386 YP_001850427.1 CDS MMAR_2122 NC_010612.1 2558638 2560350 D function unknown. possible COG0747, DdpA, ABC-type dipeptide transport system, periplasmic component [amino acid transport and metabolism]; dipeptide ABC transporter periplasmic protein 2558638..2560350 Mycobacterium marinum M 6226387 YP_001850428.1 CDS apt NC_010612.1 2560347 2560901 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 2560347..2560901 Mycobacterium marinum M 6226388 YP_001850429.1 CDS relA NC_010612.1 2560978 2563341 D involved in the metabolism of PPGPP (at the first step). in eubacteria PPGPP (guanosine 3'-diphosphate 5- 'diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. this enzyme catalyzes the formation of PPPGPP which is then hydrolysed to form PPGPP [catalytic activity: ATP + GTP = AMP + guanosine 3'- diphosphate 5-'triphosphate]; GTP pyrophosphokinase RelA 2560978..2563341 Mycobacterium marinum M 6226389 YP_001850430.1 CDS ppiB NC_010612.1 2563398 2564285 R ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides]; peptidyl-prolyl cis-trans isomerase B PpiB complement(2563398..2564285) Mycobacterium marinum M 6226390 YP_001850431.1 CDS MMAR_2126 NC_010612.1 2564426 2565100 D involved in glyoxal pathway. thioesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2- hydroxy acid anion]; Zn-dependent glyoxylase 2564426..2565100 Mycobacterium marinum M 6226391 YP_001850432.1 CDS hisS NC_010612.1 2565097 2566359 D catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2565097..2566359 Mycobacterium marinum M 6226392 YP_001850433.1 CDS MMAR_2128 NC_010612.1 2566424 2567518 D In M. tuberculosis this CDS is REGULATED BY LexA; 13e12 repeat-containing protein 2566424..2567518 Mycobacterium marinum M 6226393 YP_001850434.1 CDS MMAR_2129 NC_010612.1 2567528 2568967 D DNA integration - phage mediated; site-specific integrase 2567528..2568967 Mycobacterium marinum M 6226394 YP_001850435.1 CDS MMAR_2130 NC_010612.1 2569173 2570786 R initiation of DNA replication for an episomal element; replication initiator protein complement(2569173..2570786) Mycobacterium marinum M 6226395 YP_001850436.1 CDS MMAR_2131 NC_010612.1 2570783 2572183 R possible role in DNA segregation during cell division; DNA segregation ATPase FtsK/SpoIIIE-like protein complement(2570783..2572183) Mycobacterium marinum M 6226396 YP_001850437.1 CDS MMAR_2132 NC_010612.1 2572281 2572622 R function unknown, domain homology suggests role in initiation of plasmid replication; hypothetical protein complement(2572281..2572622) Mycobacterium marinum M 6226397 YP_001850438.1 CDS MMAR_2133 NC_010612.1 2572904 2573239 D hypothetical protein 2572904..2573239 Mycobacterium marinum M 6226398 YP_001850439.1 CDS MMAR_2134 NC_010612.1 2573226 2574443 D transcriptional regulatory protein 2573226..2574443 Mycobacterium marinum M 6226399 YP_001850440.1 CDS MMAR_2136 NC_010612.1 2575073 2575786 R metal transport protein complement(2575073..2575786) Mycobacterium marinum M 6226400 YP_001850441.1 CDS MMAR_2137 NC_010612.1 2576131 2577120 D function unknown; possibly involved in transport of metal ions across the membrane; metal transport protein 2576131..2577120 Mycobacterium marinum M 6226401 YP_001850442.1 CDS MMAR_2138 NC_010612.1 2577333 2577755 D function unknown but contains a putative protein-S- isoprenylcysteine methyltransferase domain; membrane-associated methyltransferase 2577333..2577755 Mycobacterium marinum M 6226402 YP_001850443.1 CDS MMAR_2139 NC_010612.1 2577880 2578320 D involved in transcriptional mechanism. probably ArsR-family; transcriptional regulatory protein 2577880..2578320 Mycobacterium marinum M 6226403 YP_001850444.1 CDS MMAR_2140 NC_010612.1 2578390 2580729 D metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase 2578390..2580729 Mycobacterium marinum M 6226404 YP_001850445.1 CDS MMAR_2141 NC_010612.1 2580790 2581569 R hypothetical protein complement(2580790..2581569) Mycobacterium marinum M 6226405 YP_001850446.1 CDS MMAR_2142 NC_010612.1 2582027 2582317 R hypothetical protein complement(2582027..2582317) Mycobacterium marinum M 6226406 YP_001850447.1 CDS MMAR_2143 NC_010612.1 2582330 2582581 R hypothetical protein complement(2582330..2582581) Mycobacterium marinum M 6226407 YP_001850448.1 CDS MMAR_2144 NC_010612.1 2582864 2583781 D function unknown; possibly involved in transport of metal ions across the membrane; hypothetical protein 2582864..2583781 Mycobacterium marinum M 6226408 YP_001850449.1 CDS MMAR_2145 NC_010612.1 2584200 2585831 D function unknown; contains a possible alkaline phosphatase domain; hypothetical protein 2584200..2585831 Mycobacterium marinum M 6226409 YP_001850450.1 CDS MMAR_2146 NC_010612.1 2586069 2586350 D function unknown; hypothetical protein 2586069..2586350 Mycobacterium marinum M 6226410 YP_001850451.1 CDS MMAR_2147 NC_010612.1 2586359 2588509 D metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation-transporting p-type ATPase C 2586359..2588509 Mycobacterium marinum M 6226411 YP_001850452.1 CDS MMAR_2148 NC_010612.1 2589842 2590870 D May be regulated by LexA; hypothetical protein 2589842..2590870 Mycobacterium marinum M 6226412 YP_001850453.1 CDS MMAR_2149 NC_010612.1 2590878 2592461 R hypothetical protein complement(2590878..2592461) Mycobacterium marinum M 6226413 YP_001850454.1 CDS MMAR_2150 NC_010612.1 2592500 2593345 R Contains patatin domain. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase.; patatin-like phospholipase catalysing the cleavage of fatty acids from membrane lipids; alpha-beta hydrolase superfamily esterase complement(2592500..2593345) Mycobacterium marinum M 6226414 YP_001850455.1 CDS MMAR_2151 NC_010612.1 2593374 2593856 D hypothetical protein 2593374..2593856 Mycobacterium marinum M 6226415 YP_001850456.1 CDS MMAR_2152 NC_010612.1 2593868 2594410 R function unknown. contains Cdd pfam01381, HTH_3, helix-turn-helix of DNA binding proteins; transcriptional regulator complement(2593868..2594410) Mycobacterium marinum M 6226416 YP_001850457.1 CDS MMAR_2153 NC_010612.1 2594503 2595288 D contains partial (N-terminal) Cdd pfam00596, aldolase_II, class II aldolase and adducin N-terminal domain; class II aldolase/adducin domain-containing protein 2594503..2595288 Mycobacterium marinum M 6226417 YP_001850458.1 CDS dapA_1 NC_010612.1 2595326 2596216 D involved in biosynthesis of diaminopimelate and lysine from aspartate semialdehyde (at the first step) [catalytic activity: l-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O]; dihydrodipicolinate synthase DapA 2595326..2596216 Mycobacterium marinum M 6226418 YP_001850459.1 CDS MMAR_2155 NC_010612.1 2596266 2597150 R membrane glycine rich protein complement(2596266..2597150) Mycobacterium marinum M 6226419 YP_001850460.1 CDS MMAR_2156 NC_010612.1 2597212 2597727 R hypothetical protein complement(2597212..2597727) Mycobacterium marinum M 6226420 YP_001850461.1 CDS apbA_1 NC_010612.1 2597746 2598552 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(2597746..2598552) Mycobacterium marinum M 6226421 YP_001850462.1 CDS aspS NC_010612.1 2598725 2600506 D catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2598725..2600506 Mycobacterium marinum M 6226422 YP_001850463.1 CDS MMAR_2159 NC_010612.1 2600503 2600937 D function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins; hypothetical protein 2600503..2600937 Mycobacterium marinum M 6226423 YP_001850464.1 CDS MMAR_2160 NC_010612.1 2600957 2602015 D transmembrane alanine and valine and leucine rich protein 2600957..2602015 Mycobacterium marinum M 6226424 YP_001850465.1 CDS MMAR_2161 NC_010612.1 2602022 2602420 R hypothetical protein complement(2602022..2602420) Mycobacterium marinum M 6226425 YP_001850466.1 CDS MMAR_2162 NC_010612.1 2602488 2603498 D function unknown, but contains Cdd COG1305, transglutaminase-like enzymes, putative cysteine proteases; hypothetical protein 2602488..2603498 Mycobacterium marinum M 6226426 YP_001850467.1 CDS MMAR_2163 NC_010612.1 2603491 2604546 D hypothetical protein 2603491..2604546 Mycobacterium marinum M 6226427 YP_001850468.1 CDS MMAR_2164 NC_010612.1 2604570 2607245 R hypothetical protein complement(2604570..2607245) Mycobacterium marinum M 6226428 YP_001850469.1 CDS MMAR_2165 NC_010612.1 2607291 2610641 R function unknown; possible proteolytic activity (cysteine protease); transglutaminase family protein complement(2607291..2610641) Mycobacterium marinum M 6226429 YP_001850470.1 CDS MMAR_2166 NC_010612.1 2610780 2611913 R proline and glycine rich transmembrane protein complement(2610780..2611913) Mycobacterium marinum M 6226430 YP_001850471.1 CDS MMAR_2167 NC_010612.1 2612104 2613462 D recombination factor protein RarA 2612104..2613462 Mycobacterium marinum M 6226431 YP_001850472.1 CDS MMAR_2168 NC_010612.1 2613508 2614260 R function unknown, thought to be involved in the persistence in the host; hypothetical protein complement(2613508..2614260) Mycobacterium marinum M 6226432 YP_001850473.1 CDS MMAR_2169 NC_010612.1 2614344 2614745 D hypothetical protein 2614344..2614745 Mycobacterium marinum M 6226433 YP_001850474.1 CDS alaS NC_010612.1 2614864 2617569 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2614864..2617569 Mycobacterium marinum M 6226434 YP_001850475.1 CDS MMAR_2171 NC_010612.1 2617570 2618082 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 2617570..2618082 Mycobacterium marinum M 6226435 YP_001850476.1 CDS MMAR_2172 NC_010612.1 2618075 2619331 D hypothetical protein 2618075..2619331 Mycobacterium marinum M 6226436 YP_001850477.1 CDS aroE NC_010612.1 2619328 2620161 D AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 2619328..2620161 Mycobacterium marinum M 6226437 YP_001850478.1 CDS MMAR_2174 NC_010612.1 2620173 2620616 D hypothetical protein 2620173..2620616 Mycobacterium marinum M 6226438 YP_001850479.1 CDS aroF NC_010612.1 2620693 2621916 D catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2620693..2621916 Mycobacterium marinum M 6226439 YP_001850480.1 CDS aroK NC_010612.1 2621925 2622479 D catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 2621925..2622479 Mycobacterium marinum M 6226440 YP_001850481.1 CDS aroB NC_010612.1 2622476 2623564 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 2622476..2623564 Mycobacterium marinum M 6226441 YP_001850482.1 CDS aroD NC_010612.1 2623561 2624001 D catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 2623561..2624001 Mycobacterium marinum M 6226442 YP_001850483.1 CDS MMAR_2179 NC_010612.1 2623998 2624756 R transmembrane protein complement(2623998..2624756) Mycobacterium marinum M 6226443 YP_001850484.1 CDS pepQ NC_010612.1 2624790 2625908 D function unknown, hydrolyses peptides; cytoplasmic peptidase PepQ 2624790..2625908 Mycobacterium marinum M 6226444 YP_001850485.1 CDS efp NC_010612.1 2625923 2626486 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 2625923..2626486 Mycobacterium marinum M 6226445 YP_001850486.1 CDS nusB NC_010612.1 2626489 2627010 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 2626489..2627010 Mycobacterium marinum M 6226446 YP_001850487.1 CDS MMAR_2183 NC_010612.1 2627010 2627417 D hypothetical protein 2627010..2627417 Mycobacterium marinum M 6226447 YP_001850488.1 CDS MMAR_2184 NC_010612.1 2627599 2630430 D function unknown. could be an ornithine/arginine/lysine decarboxylase involved in the biosynthesis of spermidine from arginine; amino acid decarboxylase 2627599..2630430 Mycobacterium marinum M 6226448 YP_001850489.1 CDS MMAR_2185 NC_010612.1 2630436 2631656 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(2630436..2631656) Mycobacterium marinum M 6226449 YP_001850490.1 CDS MMAR_2186 NC_010612.1 2631702 2632274 R hypothetical protein complement(2631702..2632274) Mycobacterium marinum M 6226450 YP_001850491.1 CDS MMAR_2187 NC_010612.1 2632290 2633495 R function unknown; beta-lactamase complement(2632290..2633495) Mycobacterium marinum M 6226451 YP_001850492.1 CDS lprF NC_010612.1 2633904 2634782 D lipoprotein LprF 2633904..2634782 Mycobacterium marinum M 6226452 YP_001850493.1 CDS MMAR_2189 NC_010612.1 2635049 2636512 D hypothetical protein 2635049..2636512 Mycobacterium marinum M 6226453 YP_001850494.1 CDS MMAR_2190 NC_010612.1 2636509 2637690 D chalcone/stilbene synthase 2636509..2637690 Mycobacterium marinum M 6226454 YP_001850495.1 CDS MMAR_2191 NC_010612.1 2637690 2638784 D involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids; glycolipid sulfotransferase 2637690..2638784 Mycobacterium marinum M 6226455 YP_001850496.1 CDS MMAR_2192 NC_010612.1 2638784 2639797 D involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids; glycolipid sulfotransferase 2638784..2639797 Mycobacterium marinum M 6226456 YP_001850497.1 CDS MMAR_2193 NC_010612.1 2639804 2640439 R NodS-like (sam)-dependent methyltransferase complement(2639804..2640439) Mycobacterium marinum M 6226457 YP_001850498.1 CDS pyrR NC_010612.1 2640623 2641186 D regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 2640623..2641186 Mycobacterium marinum M 6226458 YP_001850499.1 CDS pyrB NC_010612.1 2641183 2642145 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 2641183..2642145 Mycobacterium marinum M 6226459 YP_001850500.1 CDS pyrC NC_010612.1 2642142 2643434 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 2642142..2643434 Mycobacterium marinum M 6226460 YP_001850501.1 CDS MMAR_2197 NC_010612.1 2643431 2643952 D secreted protein 2643431..2643952 Mycobacterium marinum M 6226461 YP_001850502.1 CDS carA NC_010612.1 2643949 2645076 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 2643949..2645076 Mycobacterium marinum M 6226462 YP_001850503.1 CDS carB NC_010612.1 2645096 2648533 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 2645096..2648533 Mycobacterium marinum M 6226463 YP_001850504.1 CDS pyrF NC_010612.1 2648530 2649366 D type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 2648530..2649366 Mycobacterium marinum M 6226464 YP_001850505.1 CDS mihF NC_010612.1 2650323 2650658 D integration host factor MihF 2650323..2650658 Mycobacterium marinum M 6226465 YP_001850506.1 CDS gmk NC_010612.1 2650788 2651381 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 2650788..2651381 Mycobacterium marinum M 6226466 YP_001850507.1 CDS rpoZ NC_010612.1 2651468 2651800 D Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 2651468..2651800 Mycobacterium marinum M 6226467 YP_001850508.1 CDS dfp NC_010612.1 2651816 2653057 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 2651816..2653057 Mycobacterium marinum M 6226468 YP_001850509.1 CDS metK NC_010612.1 2653186 2654397 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 2653186..2654397 Mycobacterium marinum M 6226469 YP_001850510.1 CDS MMAR_2206 NC_010612.1 2654479 2655054 R hypothetical protein complement(2654479..2655054) Mycobacterium marinum M 6226470 YP_001850511.1 CDS MMAR_2207 NC_010612.1 2655146 2656630 R function unknown, probably involved in cellular metabolism; monoxygenase complement(2655146..2656630) Mycobacterium marinum M 6226471 YP_001850512.1 CDS lipH NC_010612.1 2656775 2657746 R lipase LipH complement(2656775..2657746) Mycobacterium marinum M 6226472 YP_001850513.1 CDS lipI NC_010612.1 2657773 2658747 R lipase LipI complement(2657773..2658747) Mycobacterium marinum M 6226473 YP_001850514.1 CDS MMAR_2210 NC_010612.1 2658773 2659483 D membrane protein 2658773..2659483 Mycobacterium marinum M 6226474 YP_001850515.1 CDS priA NC_010612.1 2659594 2661540 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 2659594..2661540 Mycobacterium marinum M 6226475 YP_001850516.1 CDS MMAR_2212 NC_010612.1 2661558 2662382 R causes methylation; methyltransferase complement(2661558..2662382) Mycobacterium marinum M 6226476 YP_001850517.1 CDS MMAR_2213 NC_010612.1 2662606 2663088 D involved in transcriptional mechanism; transcriptional regulatory protein 2662606..2663088 Mycobacterium marinum M 6226477 YP_001850518.1 CDS MMAR_2214 NC_010612.1 2663212 2664036 R causes methylation; methyltransferase complement(2663212..2664036) Mycobacterium marinum M 6226478 YP_001850519.1 CDS fmt NC_010612.1 2664238 2665176 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 2664238..2665176 Mycobacterium marinum M 6226479 YP_001850520.1 CDS fmu NC_010612.1 2665173 2666618 D Fmu protein 2665173..2666618 Mycobacterium marinum M 6226480 YP_001850521.1 CDS rpe NC_010612.1 2666685 2667374 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 2666685..2667374 Mycobacterium marinum M 6226481 YP_001850522.1 CDS ribG NC_010612.1 2667382 2668401 D involved in riboflavin biosynthesis (at the second and third steps). converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH]; bifunctional riboflavin biosynthesis protein RibG 2667382..2668401 Mycobacterium marinum M 6226482 YP_001850523.1 CDS MMAR_2219 NC_010612.1 2668406 2669959 R involved in transport of aminoglycosides and tetracycline across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; aminoglycosides/tetracycline-transport integral membrane protein complement(2668406..2669959) Mycobacterium marinum M 6226483 YP_001850524.1 CDS lprG NC_010612.1 2669959 2670660 R lipoprotein LprG complement(2669959..2670660) Mycobacterium marinum M 6226484 YP_001850525.1 CDS ribC NC_010612.1 2670770 2671393 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 2670770..2671393 Mycobacterium marinum M 6226485 YP_001850526.1 CDS ribA2 NC_010612.1 2671532 2672809 D bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 2671532..2672809 Mycobacterium marinum M 6226486 YP_001850527.1 CDS ribH NC_010612.1 2672806 2673288 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 2672806..2673288 Mycobacterium marinum M 6226487 YP_001850528.1 CDS MMAR_2224 NC_010612.1 2673285 2673755 D hypothetical protein 2673285..2673755 Mycobacterium marinum M 6226488 YP_001850529.1 CDS lprH NC_010612.1 2673775 2674428 D lipoprotein LprH 2673775..2674428 Mycobacterium marinum M 6226489 YP_001850530.1 CDS MMAR_2226 NC_010612.1 2674474 2675943 D In M. tuberculosis this CDS is REGULATED BY LexA; 13e12 repeat-containing protein 2674474..2675943 Mycobacterium marinum M 6226490 YP_001850531.1 CDS uvrC NC_010612.1 2675963 2677906 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2675963..2677906 Mycobacterium marinum M 6226491 YP_001850532.1 CDS MMAR_2228 NC_010612.1 2677903 2678823 D hypothetical protein 2677903..2678823 Mycobacterium marinum M 6226492 YP_001850533.1 CDS MMAR_2229 NC_010612.1 2678820 2679896 D hypothetical protein 2678820..2679896 Mycobacterium marinum M 6226493 YP_001850534.1 CDS whiA NC_010612.1 2679893 2680870 D involved in transcriptional mechanism; transcriptional regulatory protein WhiA 2679893..2680870 Mycobacterium marinum M 6226494 YP_001850535.1 CDS MMAR_2231 NC_010612.1 2680973 2682355 D hypothetical protein 2680973..2682355 Mycobacterium marinum M 6226495 YP_001850536.1 CDS lipO NC_010612.1 2682356 2683639 R function unknown, but supposed involved in lipid metabolism; esterase LipO complement(2682356..2683639) Mycobacterium marinum M 6226496 YP_001850537.1 CDS fadD12 NC_010612.1 2683636 2685270 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(2683636..2685270) Mycobacterium marinum M 6226497 YP_001850538.1 CDS MMAR_2234 NC_010612.1 2685274 2686077 R hypothetical protein complement(2685274..2686077) Mycobacterium marinum M 6226498 YP_001850539.1 CDS MMAR_2235 NC_010612.1 2686288 2688126 D PE-PGRS family protein 2686288..2688126 Mycobacterium marinum M 6226499 YP_001850540.1 CDS MMAR_2236 NC_010612.1 2688330 2690078 D hypothetical protein 2688330..2690078 Mycobacterium marinum M 6226500 YP_001850541.1 CDS MMAR_2237 NC_010612.1 2690075 2691496 D function unknown, probably involved in cellular metabolism; dehydrogenase 2690075..2691496 Mycobacterium marinum M 6226501 YP_001850542.1 CDS MMAR_2238 NC_010612.1 2691504 2692313 R hypothetical protein complement(2691504..2692313) Mycobacterium marinum M 6226502 YP_001850543.1 CDS gap NC_010612.1 2692597 2693616 D involved in second phase of glycolysis (first step) [catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.]; glyceraldehyde 3-phosphate dehydrogenase Gap 2692597..2693616 Mycobacterium marinum M 6226503 YP_001850544.1 CDS pgk NC_010612.1 2693629 2694879 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 2693629..2694879 Mycobacterium marinum M 6226504 YP_001850545.1 CDS tpiA NC_010612.1 2694876 2695661 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 2694876..2695661 Mycobacterium marinum M 6226505 YP_001850546.1 CDS gabT_1 NC_010612.1 2695706 2698645 R involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: 4-aminobutanoate + 2- oxoglutarate = succinate semialdehyde + L-glutamate]; hypothetical protein complement(2695706..2698645) Mycobacterium marinum M 6226506 YP_001850547.1 CDS MMAR_2243 NC_010612.1 2698642 2700030 R thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane; cationic amino acid transport integral membrane protein complement(2698642..2700030) Mycobacterium marinum M 6226507 YP_001850548.1 CDS MMAR_2244 NC_010612.1 2700262 2700990 D possibly involved in transcriptional mechanism; GntR family transcriptional regulator 2700262..2700990 Mycobacterium marinum M 6226508 YP_001850549.1 CDS MMAR_2245 NC_010612.1 2701024 2701512 R hypothetical protein complement(2701024..2701512) Mycobacterium marinum M 6226509 YP_001850550.1 CDS secG NC_010612.1 2701527 2701760 R involved in protein export. participates in a early event of protein translocation; preprotein translocase subunit SecG complement(2701527..2701760) Mycobacterium marinum M 6226510 YP_001850551.1 CDS ppc NC_010612.1 2701830 2704637 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 2701830..2704637 Mycobacterium marinum M 6226511 YP_001850552.1 CDS MMAR_2248 NC_010612.1 2704661 2705977 R PE-PGRS family protein complement(2704661..2705977) Mycobacterium marinum M 6226512 YP_001850553.1 CDS MMAR_2249 NC_010612.1 2706073 2706471 R hypothetical protein complement(2706073..2706471) Mycobacterium marinum M 6226513 YP_001850554.1 CDS devB NC_010612.1 2706521 2707264 R involved in pentose phosphate pathway. hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. [catalytic activity : 6-phospho-D-glucono-1,5-lactone + H(2)O = 6- phospho-D-gluconate]; 6-phosphogluconolactonase complement(2706521..2707264) Mycobacterium marinum M 6226514 YP_001850555.1 CDS opcA NC_010612.1 2707261 2708172 R may be involved in the functional assembly of glucose 6-phosphate dehydrogenase; OXPP cycle protein OpcA complement(2707261..2708172) Mycobacterium marinum M 6226515 YP_001850556.1 CDS zwf2 NC_010612.1 2708275 2709828 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(2708275..2709828) Mycobacterium marinum M 6226516 YP_001850557.1 CDS tal NC_010612.1 2709825 2710946 R catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase complement(2709825..2710946) Mycobacterium marinum M 6226517 YP_001850558.1 CDS tkt NC_010612.1 2710962 2713064 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(2710962..2713064) Mycobacterium marinum M 6226518 YP_001850559.1 CDS ctaB NC_010612.1 2713352 2714326 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 2713352..2714326 Mycobacterium marinum M 6226519 YP_001850560.1 CDS hemY_1 NC_010612.1 2714406 2715773 R involved in HemE and porphyrin biosynthesis (at the penultimate step). catalyzes the 6-electron oxidation of protoporphyrinogen ix to form protoporphyrin ix [catalytic activity: protoporphyrinogen-IX + O(2) = protoporphyrin-IX + H(2)O(2)]; protoporphyrinogen oxidase, HemY complement(2714406..2715773) Mycobacterium marinum M 6226520 YP_001850561.1 CDS otsB1 NC_010612.1 2716209 2719865 D involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway). seems to have additional alpha-glucosidase activity; trehalose-6-phosphate phosphatase OtsB1 2716209..2719865 Mycobacterium marinum M 6226521 YP_001850562.1 CDS MMAR_2258 NC_010612.1 2719993 2721276 D involved in transcriptional mechanism; transcriptional activator protein 2719993..2721276 Mycobacterium marinum M 6226522 YP_001850563.1 CDS qor NC_010612.1 2721330 2722340 R catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone reductase Qor complement(2721330..2722340) Mycobacterium marinum M 6226523 YP_001850564.1 CDS MMAR_2260 NC_010612.1 2722339 2723193 D hypothetical protein 2722339..2723193 Mycobacterium marinum M 6226524 YP_001850565.1 CDS MMAR_2261 NC_010612.1 2723143 2724099 R thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; antibiotic ABC transporter transmembrane protein complement(2723143..2724099) Mycobacterium marinum M 6226525 YP_001850566.1 CDS MMAR_2262 NC_010612.1 2724143 2724931 R thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; antibiotic ABC transporter transmembrane protein complement(2724143..2724931) Mycobacterium marinum M 6226526 YP_001850567.1 CDS MMAR_2263 NC_010612.1 2724928 2725887 R thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system; antibiotic ABC transporter ATP-binding protein complement(2724928..2725887) Mycobacterium marinum M 6226527 YP_001850568.1 CDS MMAR_2264 NC_010612.1 2725884 2727701 R integral membrane protein complement(2725884..2727701) Mycobacterium marinum M 6226528 YP_001850569.1 CDS MMAR_2265 NC_010612.1 2727782 2728567 D involved in transcriptional mechanism; transcriptional regulatory protein 2727782..2728567 Mycobacterium marinum M 6226529 YP_001850570.1 CDS MMAR_2266 NC_010612.1 2728564 2730009 D hypothetical protein 2728564..2730009 Mycobacterium marinum M 6226530 YP_001850571.1 CDS MMAR_2267 NC_010612.1 2730006 2731205 D hypothetical protein 2730006..2731205 Mycobacterium marinum M 6226531 YP_001850572.1 CDS MMAR_2268 NC_010612.1 2731202 2731984 D thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 2731202..2731984 Mycobacterium marinum M 6226532 YP_001850573.1 CDS csd NC_010612.1 2731987 2733240 D catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, l- selenocysteine, and L-selenocystine to produce L-alanine; cysteine desulfurase 2731987..2733240 Mycobacterium marinum M 6226533 YP_001850574.1 CDS MMAR_2270 NC_010612.1 2733243 2733734 D function unknown, probably involved in cellular metabolism; nitrogen fixation-like protein 2733243..2733734 Mycobacterium marinum M 6226534 YP_001850575.1 CDS MMAR_2271 NC_010612.1 2733727 2734074 D hypothetical protein 2733727..2734074 Mycobacterium marinum M 6226535 YP_001850576.1 CDS MMAR_2272 NC_010612.1 2734258 2735727 D PE-PGRS family protein 2734258..2735727 Mycobacterium marinum M 6226536 YP_001850577.1 CDS fadE15 NC_010612.1 2735739 2737568 R function unknown, but involvement in lipid degradation; acyl-CoA dehydrogenase FadE15 complement(2735739..2737568) Mycobacterium marinum M 6226537 YP_001850578.1 CDS MMAR_2274 NC_010612.1 2737674 2738771 R PE-PGRS family protein complement(2737674..2738771) Mycobacterium marinum M 6226538 YP_001850579.1 CDS ctpD NC_010612.1 2739119 2741098 D cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly cadmium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation transporter p-type ATPase D CtpD 2739119..2741098 Mycobacterium marinum M 6226539 YP_001850580.1 CDS trxA NC_010612.1 2741193 2741549 D thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin TrxA 2741193..2741549 Mycobacterium marinum M 6226540 YP_001850581.1 CDS trxB1 NC_010612.1 2741606 2741944 D thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin TrxB1 2741606..2741944 Mycobacterium marinum M 6226541 YP_001850582.1 CDS echA12 NC_010612.1 2742028 2742837 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2742028..2742837 Mycobacterium marinum M 6226542 YP_001850583.1 CDS MMAR_2279 NC_010612.1 2742862 2744490 D probable macrolide-transport ATP-binding protein ABC transporter. thought to be involved in active transport of macrolide across the membrane; ABC transporter ATP-binding protein 2742862..2744490 Mycobacterium marinum M 6226543 YP_001850584.1 CDS MMAR_2280 NC_010612.1 2744575 2744766 D involved in transcriptional mechanism; transcriptional regulatory protein 2744575..2744766 Mycobacterium marinum M 6226544 YP_001850585.1 CDS MMAR_2281 NC_010612.1 2744768 2745331 R involved in transcriptional mechanism; transcriptional regulatory protein complement(2744768..2745331) Mycobacterium marinum M 6226545 YP_001850586.1 CDS acn NC_010612.1 2745341 2748142 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(2745341..2748142) Mycobacterium marinum M 6226546 YP_001850587.1 CDS MMAR_2283 NC_010612.1 2748463 2749014 D hypothetical protein 2748463..2749014 Mycobacterium marinum M 6226547 YP_001850588.1 CDS iipA NC_010612.1 2749246 2750655 D similar to a hypothetical invasion protein. possibly an exported protein with unusually long signal sequence. NLP/P60 family protein; invasion and intracellular persistence protein, IipA 2749246..2750655 Mycobacterium marinum M 6226548 YP_001850589.1 CDS iipB NC_010612.1 2750660 2751400 D homology to cell wall-associated hydrolases. possibly an exported protein of the NLP/P60 family; invasion and intracellular persistence protein, IipB 2750660..2751400 Mycobacterium marinum M 6226549 YP_001850590.1 CDS moxR1 NC_010612.1 2751599 2752714 D involved in transcriptional mechanism; transcriptional regulatory protein, MoxR1 2751599..2752714 Mycobacterium marinum M 6226550 YP_001850591.1 CDS MMAR_2287 NC_010612.1 2752729 2753685 D hypothetical protein 2752729..2753685 Mycobacterium marinum M 6226551 YP_001850592.1 CDS MMAR_2288 NC_010612.1 2753720 2754727 D hypothetical protein 2753720..2754727 Mycobacterium marinum M 6226552 YP_001850593.1 CDS fabG1 NC_010612.1 2754841 2755608 D involved in the fatty acid biosynthesis pathway (first reduction step) (mycolic acid biosynthesis); reduces KasA/KasB products [catalytic activity: (3R)-3- hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl- [acyl-carrier protein] + NADPH]; 3-oxoacyl-ACP reductase 2754841..2755608 Mycobacterium marinum M 6226553 YP_001850594.1 CDS inhA NC_010612.1 2755688 2756497 D Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 2755688..2756497 Mycobacterium marinum M 6226554 YP_001850595.1 CDS hemH NC_010612.1 2756504 2757526 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 2756504..2757526 Mycobacterium marinum M 6226555 YP_001850596.1 CDS MMAR_2292 NC_010612.1 2757533 2758525 R hypothetical protein complement(2757533..2758525) Mycobacterium marinum M 6226556 YP_001850597.1 CDS MMAR_2293 NC_010612.1 2758541 2758975 D function unknown. contains Cdd match to COG1585, COG1585, membrane protein implicated in regulation of membrane protease activity [posttranslational modification, protein turnover, chaperones / intracellular trafficking and secretion]; hypothetical protein 2758541..2758975 Mycobacterium marinum M 6226557 YP_001850598.1 CDS MMAR_2294 NC_010612.1 2758997 2760151 D hypothetical protein 2758997..2760151 Mycobacterium marinum M 6226558 YP_001850599.1 CDS MMAR_2295 NC_010612.1 2760148 2760504 D hypothetical protein 2760148..2760504 Mycobacterium marinum M 6226559 YP_001850600.1 CDS MMAR_2296 NC_010612.1 2760501 2760968 R hypothetical protein complement(2760501..2760968) Mycobacterium marinum M 6226560 YP_001850601.1 CDS MMAR_2297 NC_010612.1 2761001 2761615 R involved in transcriptional mechanism; transcriptional regulator complement(2761001..2761615) Mycobacterium marinum M 6226561 YP_001850602.1 CDS MMAR_2298 NC_010612.1 2762490 2763233 D contains N-terminal Cdd pfam00072, response_reg, response regulator receiver domain. this domain receives the signal from the sensor partner in bacterial two- component systems. it is usually found N-terminal to a DNA binding effector domain. C-terminal conatins Cdd pfam00486, trans_reg_C, transcriptional regulatory protein, C terminal; two-component regulator receiver domain-containing protein 2762490..2763233 Mycobacterium marinum M 6226562 YP_001850603.1 CDS MMAR_2299 NC_010612.1 2763233 2764753 D two-component system response sensor kinase contains Cdd pfam02518, hATPase_C, histidine kinase-, DNA gyrase B-, and Hsp90-like ATPase; Cdd pfam00512, HisKA, his kinase a (phosphoacceptor) domain. dimerisation and phosphoacceptor domain of histidine kinases; two-component regulator - sensor kinase 2763233..2764753 Mycobacterium marinum M 6226563 YP_001850604.1 CDS MMAR_2300 NC_010612.1 2764758 2765732 R hypothetical protein complement(2764758..2765732) Mycobacterium marinum M 6226564 YP_001850605.1 CDS MMAR_2301 NC_010612.1 2765797 2766570 R conserved membrane protein of unknown function. similar to proteins from many organisms containing Cdd COG0398; uncharacterized conserved protein [function unknown]; hypothetical protein complement(2765797..2766570) Mycobacterium marinum M 6226565 YP_001850606.1 CDS mutA NC_010612.1 2766763 2768640 D involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity: (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA]; methylmalonyl-CoA mutase small subunit, MutA 2766763..2768640 Mycobacterium marinum M 6226566 YP_001850607.1 CDS mutB NC_010612.1 2768646 2770907 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 2768646..2770907 Mycobacterium marinum M 6226567 YP_001850608.1 CDS MMAR_2304 NC_010612.1 2770975 2771985 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 2770975..2771985 Mycobacterium marinum M 6226568 YP_001850609.1 CDS lipL NC_010612.1 2772049 2773335 D function unknown, but supposed involvement in lipid metabolism; esterase LipL 2772049..2773335 Mycobacterium marinum M 6226569 YP_001850610.1 CDS MMAR_2306 NC_010612.1 2773355 2773567 R function unknown. contains Cdd pfam07311, DUF1458, protein of unknown function (DUF1458). this family consists of several hypothetical bacterial proteins as well as one archaeal sequence. members of this family are typically of around 70 residues in length. the function of this family is unknown; hypothetical protein complement(2773355..2773567) Mycobacterium marinum M 6226570 YP_001850611.1 CDS MMAR_2307 NC_010612.1 2773695 2775599 R hypothetical protein complement(2773695..2775599) Mycobacterium marinum M 6226571 YP_001850612.1 CDS MMAR_2308 NC_010612.1 2775619 2776110 R hypothetical protein complement(2775619..2776110) Mycobacterium marinum M 6226572 YP_001850613.1 CDS udgL NC_010612.1 2776434 2777690 D involved in lipooligosaccharide biosynthesis [catalytic activity: UDP-glucose + 2 NAD+ + H2O = UDP- glucuronate + 2 NADH]. belongs to UDP-glucose/GDP-mannose dehydrogenase family; UDP-glucose 6-dehydrogenase, UdgL 2776434..2777690 Mycobacterium marinum M 6226573 YP_001850614.1 CDS galE5 NC_010612.1 2777687 2778706 D involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose]; UDP-glucose 4-epimerase 2777687..2778706 Mycobacterium marinum M 6226574 YP_001850615.1 CDS MMAR_2311 NC_010612.1 2778736 2780229 D contains Cdd pfam00535 glycosyl transferase. diverse family, transferring sugar from UDP-glucose, UDP-N- acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family protein 2778736..2780229 Mycobacterium marinum M 6226575 YP_001850616.1 CDS MMAR_2312 NC_010612.1 2780315 2781247 D contains Cdd COG0451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane - carbohydrate transport and metabolism]; nucleoside-diphosphate-sugar epimerase 2780315..2781247 Mycobacterium marinum M 6226576 YP_001850617.1 CDS losA NC_010612.1 2781541 2782575 D involved in the final assembly of the M. marinum LOS-IV glycolipid; glycosyltransferase, LosA 2781541..2782575 Mycobacterium marinum M 6226577 YP_001850618.1 CDS MMAR_2314 NC_010612.1 2782572 2783393 D function unknown; hypothetical protein 2782572..2783393 Mycobacterium marinum M 6226578 YP_001850619.1 CDS MMAR_2315 NC_010612.1 2783614 2784486 D methylation of unknown substrate; methyltransferase 2783614..2784486 Mycobacterium marinum M 6226579 YP_001850620.1 CDS MMAR_2316 NC_010612.1 2784600 2785247 D involved in transcriptional mechanism; transcriptional regulator 2784600..2785247 Mycobacterium marinum M 6226580 YP_001850621.1 CDS MMAR_2317 NC_010612.1 2785253 2786098 D O-methyltransferase 2785253..2786098 Mycobacterium marinum M 6226581 YP_001850622.1 CDS MMAR_2318 NC_010612.1 2786359 2787267 D hypothetical protein 2786359..2787267 Mycobacterium marinum M 6226582 YP_001850623.1 CDS MMAR_2319 NC_010612.1 2787300 2788937 R hypothetical protein complement(2787300..2788937) Mycobacterium marinum M 6226583 YP_001850624.1 CDS wecE NC_010612.1 2788950 2790098 R catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase complement(2788950..2790098) Mycobacterium marinum M 6226584 YP_001850625.1 CDS MMAR_2321 NC_010612.1 2790240 2790905 R function unknown but contains left-handed parallel beta-helix, with 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[Stav]-X- [Liv]-[gaed]-X). proteins containing hexapeptide repeats are often enzymes showing acyl-transferase activity; acyltransferase complement(2790240..2790905) Mycobacterium marinum M 6226585 YP_001850626.1 CDS MMAR_2322 NC_010612.1 2790902 2791537 R hypothetical protein complement(2790902..2791537) Mycobacterium marinum M 6226586 YP_001850627.1 CDS MMAR_2323 NC_010612.1 2791869 2793755 R hypothetical protein complement(2791869..2793755) Mycobacterium marinum M 6226587 YP_001850628.1 CDS MMAR_2324 NC_010612.1 2793975 2794268 D hypothetical protein 2793975..2794268 Mycobacterium marinum M 6226588 YP_001850629.1 CDS MMAR_2325 NC_010612.1 2794381 2795019 R hypothetical protein complement(2794381..2795019) Mycobacterium marinum M 6226589 YP_001850630.1 CDS MMAR_2326 NC_010612.1 2795179 2795601 D hypothetical protein 2795179..2795601 Mycobacterium marinum M 6226590 YP_001850631.1 CDS MMAR_2327 NC_010612.1 2795598 2797166 D hypothetical protein 2795598..2797166 Mycobacterium marinum M 6226591 YP_001850632.1 CDS MMAR_2328 NC_010612.1 2797219 2798496 R function unknown role in carbohydrate metabolism; putative sugar kinase complement(2797219..2798496) Mycobacterium marinum M 6226592 YP_001850633.1 CDS aroB_2 NC_010612.1 2798468 2799550 R involved at the second step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: 7-phospho-3- deoxy-arabino-heptulosonate = 3-dehydroquinate + orthophosphate]; 3-dehydroquinate synthase complement(2798468..2799550) Mycobacterium marinum M 6226593 YP_001850634.1 CDS MMAR_2330 NC_010612.1 2799547 2800236 R short chain dehydrogenase complement(2799547..2800236) Mycobacterium marinum M 6226594 YP_001850635.1 CDS MMAR_2331 NC_010612.1 2800374 2801174 R hypothetical protein complement(2800374..2801174) Mycobacterium marinum M 6226595 YP_001850636.1 CDS ilvB1_3 NC_010612.1 2801343 2803163 R involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate]; acetolactate synthase large subunit IlvB complement(2801343..2803163) Mycobacterium marinum M 6226596 YP_001850637.1 CDS wcaA NC_010612.1 2803160 2804116 R function unknown. maybe involved in cell wall biogenesis; glycosyltransferase, WcaA complement(2803160..2804116) Mycobacterium marinum M 6226597 YP_001850638.1 CDS MMAR_2334 NC_010612.1 2804113 2804850 R function unknown - may be involved in [cell envelope biogenesis by transfer of nucleotides onto phosphosugars; nucleotidyltransferase complement(2804113..2804850) Mycobacterium marinum M 6226598 YP_001850639.1 CDS MMAR_2335 NC_010612.1 2805067 2806410 D may be involved in regulation of cell wall biogenesis; pyridoxal phosphate-dependent enzyme 2805067..2806410 Mycobacterium marinum M 6226599 YP_001850640.1 CDS galE6 NC_010612.1 2806413 2807429 D possibly involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase 2806413..2807429 Mycobacterium marinum M 6226600 YP_001850641.1 CDS MMAR_2337 NC_010612.1 2807426 2807926 D hypothetical protein 2807426..2807926 Mycobacterium marinum M 6226601 YP_001850642.1 CDS MMAR_2338 NC_010612.1 2807893 2809512 R hypothetical protein complement(2807893..2809512) Mycobacterium marinum M 6226602 YP_001850643.1 CDS MMAR_2339 NC_010612.1 2809852 2810508 R SAM-dependent methyltransferase complement(2809852..2810508) Mycobacterium marinum M 6226603 YP_001850644.1 CDS pks5 NC_010612.1 2810562 2816834 R synthesis of unknown metabolite. single module with the following domains: KS, ATP, ER, KR, ACP; polyketide synthase Pks5 complement(2810562..2816834) Mycobacterium marinum M 6226604 YP_001850645.1 CDS fadD25 NC_010612.1 2817295 2819052 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2817295..2819052 Mycobacterium marinum M 6226605 YP_001850646.1 CDS MMAR_2342 NC_010612.1 2819321 2823694 R thought to be involved in fatty acid transport; MmpL family transport protein complement(2819321..2823694) Mycobacterium marinum M 6226606 YP_001850647.1 CDS MMAR_2343 NC_010612.1 2824080 2825516 R function unknown. contains a non-ribosomal peptide (Nrp) condensation domain. possibly involved in the synthesis of a hybrid NRP-PKS; hypothetical protein complement(2824080..2825516) Mycobacterium marinum M 6226607 YP_001850648.1 CDS pks5_1 NC_010612.1 2825569 2831823 R function unknown, catalyzes the elongation of N- fatty acyl-CoA with methylamalonyl-CoA. single module with domain structure: KS, ATP, DH, ER, KR, ACP; polyketide synthase complement(2825569..2831823) Mycobacterium marinum M 6226608 YP_001850649.1 CDS MMAR_2345 NC_010612.1 2832079 2832642 D hypothetical protein 2832079..2832642 Mycobacterium marinum M 6226609 YP_001850650.1 CDS MMAR_2346 NC_010612.1 2832775 2833908 D function unknown; identity with NPD, 2-nitropropane dioxygenase. members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor; dioxygenase 2832775..2833908 Mycobacterium marinum M 6226610 YP_001850651.1 CDS MMAR_2347 NC_010612.1 2834185 2834352 D hypothetical protein 2834185..2834352 Mycobacterium marinum M 6226611 YP_001850652.1 CDS MMAR_2348 NC_010612.1 2834541 2834774 D hypothetical protein 2834541..2834774 Mycobacterium marinum M 6226612 YP_001850653.1 CDS wbbL2 NC_010612.1 2835032 2835799 D possibly involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall; rhamnosyl transferase WbbL2 2835032..2835799 Mycobacterium marinum M 6226613 YP_001850654.1 CDS MMAR_2350 NC_010612.1 2835845 2836516 R function unknown, domain identity to UbiG, 2- polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylases; methylase complement(2835845..2836516) Mycobacterium marinum M 6226614 YP_001850655.1 CDS MMAR_2351 NC_010612.1 2836618 2837367 D function unknown. contains Cdd pfam00535, glycos_transf_2, glycosyl transferase. diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family protein 2836618..2837367 Mycobacterium marinum M 6226615 YP_001850656.1 CDS MMAR_2352 NC_010612.1 2837485 2838219 R hypothetical protein complement(2837485..2838219) Mycobacterium marinum M 6226616 YP_001850657.1 CDS MMAR_2353 NC_010612.1 2838244 2839488 R function unknown. contains Cdd COG1819, glycosyl transferases, related to UDP-glucuronosyltransferase [carbohydrate transport and metabolism / signal transduction mechanisms]; UDP-glycosyltransferase complement(2838244..2839488) Mycobacterium marinum M 6226617 YP_001850658.1 CDS MMAR_2354 NC_010612.1 2839552 2840925 R function unknown. similarity to Cdd pfam03007. uncharacterised protein family (UPF0089). this family of uncharacterised proteins is greatly expanded in mycobacterium tuberculosis. the most conserved region of the proteins contains conserved histidine and aspartate residues suggesting a possible metal binding site suggestive of a protease activity; hypothetical protein complement(2839552..2840925) Mycobacterium marinum M 6226618 YP_001850659.1 CDS papA3 NC_010612.1 2840940 2842448 R function unknown. thought to be involved in lipid metabolism; polyketide synthase associated protein PapA3 complement(2840940..2842448) Mycobacterium marinum M 6226619 YP_001850660.1 CDS ileS NC_010612.1 2843147 2846347 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 2843147..2846347 Mycobacterium marinum M 6226620 YP_001850661.1 CDS MMAR_2357 NC_010612.1 2846352 2847404 R function unknown; hypothetical protein complement(2846352..2847404) Mycobacterium marinum M 6226621 YP_001850662.1 CDS MMAR_2358 NC_010612.1 2847460 2848032 R function unknown. partial Cdd COG0030, KsgA, dimethyladenosine transferase (rRNA methylation) [translation, ribosomal structure and biogenesis]; hypothetical protein complement(2847460..2848032) Mycobacterium marinum M 6226622 YP_001850663.1 CDS dinP_1 NC_010612.1 2848099 2849511 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 2848099..2849511 Mycobacterium marinum M 6226623 YP_001850664.1 CDS ansA NC_010612.1 2849476 2850432 R conversion of asparagine to aspartate; L-aparaginase AnsA complement(2849476..2850432) Mycobacterium marinum M 6226624 YP_001850665.1 CDS lspA NC_010612.1 2850508 2851098 D this protein specifically catalyzes the removal of signal peptides from prolipoproteins [catalytic activity : cleavage of N-terminal leader sequences from membrane prolipoproteins; lipoprotein signal peptidase LspA 2850508..2851098 Mycobacterium marinum M 6226625 YP_001850666.1 CDS MMAR_2362 NC_010612.1 2851113 2852024 D pseudouridine synthase (pseudouridylate synthase) (uracil hydrolyase)[catalytic activity] uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O; RluA family pseudouridine synthase 2851113..2852024 Mycobacterium marinum M 6226626 YP_001850667.1 CDS MMAR_2363 NC_010612.1 2852033 2852803 R function unknown. contains partial Cdd COG2226, UbiE, methylase involved in ubiquinone/menaquinone biosynthesis; hypothetical protein complement(2852033..2852803) Mycobacterium marinum M 6226627 YP_001850668.1 CDS lprL NC_010612.1 2853097 2853732 R function unknown; lipoprotein, LprL complement(2853097..2853732) Mycobacterium marinum M 6226628 YP_001850669.1 CDS glbN NC_010612.1 2853816 2854226 R oxygen transport. this family of HemE binding proteins are found mainly in bacteria; globin family protein complement(2853816..2854226) Mycobacterium marinum M 6226629 YP_001850670.1 CDS MMAR_2366 NC_010612.1 2854465 2855481 D thought to reduce acyl-CoA esters of fatty acids to fatty aldehydes; fatty acyl-CoA reductase 2854465..2855481 Mycobacterium marinum M 6226630 YP_001850671.1 CDS MMAR_2367 NC_010612.1 2855486 2856289 D possibly involvement in lipid metabolism; ketoacyl reductase 2855486..2856289 Mycobacterium marinum M 6226631 YP_001850672.1 CDS MMAR_2368 NC_010612.1 2856409 2856840 D hypothetical protein 2856409..2856840 Mycobacterium marinum M 6226632 YP_001850673.1 CDS dnaE NC_010612.1 2856907 2860449 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 2856907..2860449 Mycobacterium marinum M 6226633 YP_001850674.1 CDS fadD11 NC_010612.1 2860576 2862402 D probably involved in lipid degradation; fatty-acid-CoA ligase FadD11 2860576..2862402 Mycobacterium marinum M 6226634 YP_001850675.1 CDS plsB1 NC_010612.1 2862417 2864291 D PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 2862417..2864291 Mycobacterium marinum M 6226635 YP_001850676.1 CDS MMAR_2372 NC_010612.1 2864299 2864529 R function unknown; hypothetical protein complement(2864299..2864529) Mycobacterium marinum M 6226636 YP_001850677.1 CDS MMAR_2373 NC_010612.1 2864632 2865069 D function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins; hypothetical protein 2864632..2865069 Mycobacterium marinum M 6226637 YP_001850678.1 CDS ilvA NC_010612.1 2865103 2866383 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 2865103..2866383 Mycobacterium marinum M 6226638 YP_001850679.1 CDS MMAR_2375 NC_010612.1 2866411 2867055 R hypothetical protein complement(2866411..2867055) Mycobacterium marinum M 6226639 YP_001850680.1 CDS MMAR_2376 NC_010612.1 2867097 2868422 D involved in transcriptional mechanism; GntR family transcriptional regulator 2867097..2868422 Mycobacterium marinum M 6226640 YP_001850681.1 CDS treZ NC_010612.1 2868435 2870198 R involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); maltooligosyltrehalose trehalohydrolase, TreZ complement(2868435..2870198) Mycobacterium marinum M 6226641 YP_001850682.1 CDS treY NC_010612.1 2870195 2872492 R involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway); maltooligosyltrehalose synthase TreY complement(2870195..2872492) Mycobacterium marinum M 6226642 YP_001850683.1 CDS treX NC_010612.1 2872496 2874673 R possibly involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway); maltooligosyltrehalose synthase TreX complement(2872496..2874673) Mycobacterium marinum M 6226643 YP_001850684.1 CDS MMAR_2380 NC_010612.1 2874773 2876938 R hypothetical protein complement(2874773..2876938) Mycobacterium marinum M 6226644 YP_001850685.1 CDS MMAR_2381 NC_010612.1 2877046 2877825 R possible inv protein, probably exported as has QQAPV repeats at c-terminus; inv protein complement(2877046..2877825) Mycobacterium marinum M 6226645 YP_001850686.1 CDS MMAR_2382 NC_010612.1 2878171 2878614 R hypothetical protein complement(2878171..2878614) Mycobacterium marinum M 6226646 YP_001850687.1 CDS bioA NC_010612.1 2878708 2880021 D catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 2878708..2880021 Mycobacterium marinum M 6226647 YP_001850688.1 CDS bioF1 NC_010612.1 2880028 2881197 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 2880028..2881197 Mycobacterium marinum M 6226648 YP_001850689.1 CDS bioD NC_010612.1 2881194 2881874 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 2881194..2881874 Mycobacterium marinum M 6226649 YP_001850690.1 CDS MMAR_2386 NC_010612.1 2881876 2882385 D hypothetical protein 2881876..2882385 Mycobacterium marinum M 6226650 YP_001850691.1 CDS bioB NC_010612.1 2882538 2883587 D catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 2882538..2883587 Mycobacterium marinum M 6226651 YP_001850692.1 CDS MMAR_5574 NC_010612.1 2883603 2883830 D hypothetical protein 2883603..2883830 Mycobacterium marinum M 6226652 YP_001850693.1 CDS MMAR_2388 NC_010612.1 2883953 2884525 D hypothetical protein 2883953..2884525 Mycobacterium marinum M 6226653 YP_001850694.1 CDS MMAR_2389 NC_010612.1 2884571 2885938 R hypothetical protein complement(2884571..2885938) Mycobacterium marinum M 6226654 YP_001850695.1 CDS MMAR_2390 NC_010612.1 2886268 2886975 R function unknown, domain identity to ADP-ribose pyrophosphatases, possible role in nucleotide transport and metabolism; hypothetical protein complement(2886268..2886975) Mycobacterium marinum M 6226655 YP_001850696.1 CDS nadA NC_010612.1 2887023 2888081 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 2887023..2888081 Mycobacterium marinum M 6226656 YP_001850697.1 CDS nadB NC_010612.1 2888078 2889652 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2888078..2889652 Mycobacterium marinum M 6226657 YP_001850698.1 CDS nadC NC_010612.1 2889652 2890509 D catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 2889652..2890509 Mycobacterium marinum M 6226658 YP_001850699.1 CDS MMAR_2394 NC_010612.1 2890571 2890981 R hypothetical protein complement(2890571..2890981) Mycobacterium marinum M 6226659 YP_001850700.1 CDS hisD NC_010612.1 2891066 2892409 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2891066..2892409 Mycobacterium marinum M 6226660 YP_001850701.1 CDS hisC1 NC_010612.1 2892406 2893554 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2892406..2893554 Mycobacterium marinum M 6226661 YP_001850702.1 CDS hisB NC_010612.1 2893551 2894183 D catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 2893551..2894183 Mycobacterium marinum M 6226662 YP_001850703.1 CDS hisH NC_010612.1 2894180 2894812 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2894180..2894812 Mycobacterium marinum M 6226663 YP_001850704.1 CDS hisA NC_010612.1 2894809 2895558 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 2894809..2895558 Mycobacterium marinum M 6226664 YP_001850705.1 CDS impA NC_010612.1 2895565 2896377 D involved in inositol phosphate metabolism. it is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. key enzyme of the phosphatidyl inositol signaling pathway [catalytic activity: inositol 1(or 4)-monophosphate + H(2)O = inositol + orthophosphate]; inositol-monophosphatase ImpA 2895565..2896377 Mycobacterium marinum M 6226665 YP_001850706.1 CDS hisF NC_010612.1 2896379 2897164 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2896379..2897164 Mycobacterium marinum M 6226666 YP_001850707.1 CDS hisI NC_010612.1 2897161 2897496 D PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 2897161..2897496 Mycobacterium marinum M 6226667 YP_001850708.1 CDS MMAR_2403 NC_010612.1 2897619 2898710 R function unknown; deacylase complement(2897619..2898710) Mycobacterium marinum M 6226668 YP_001850709.1 CDS MMAR_2404 NC_010612.1 2898715 2899059 R hypothetical protein complement(2898715..2899059) Mycobacterium marinum M 6226669 YP_001850710.1 CDS cphB NC_010612.1 2899081 2901285 R function unknown, possibly involved in secondary metabolites biosynthesis, transport, and catabolism / inorganic ion transport and metabolism; cyanophycinase CphB complement(2899081..2901285) Mycobacterium marinum M 6226670 YP_001850711.1 CDS MMAR_2406 NC_010612.1 2901282 2904017 R catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase complement(2901282..2904017) Mycobacterium marinum M 6226671 YP_001850712.1 CDS rocE_1 NC_010612.1 2904612 2906105 D thought to be involved in transport of cationic amino acid (especially arginine and ornithine) across the membrane. responsible for the translocation of the substrate across the membrane; cationic amino acid transport integral membrane protein, RocE 2904612..2906105 Mycobacterium marinum M 6226672 YP_001850713.1 CDS pknF_1 NC_010612.1 2906309 2907823 R involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; anchored-membrane serine/threonine-protein kinase PknF complement(2906309..2907823) Mycobacterium marinum M 6226673 YP_001850714.1 CDS chaA NC_010612.1 2908067 2909149 D involved in transport of ions (presumably calcium) across the membrane. responsible for the translocation of the substrate across the membrane; ionic transporter integral membrane protein ChaA 2908067..2909149 Mycobacterium marinum M 6226674 YP_001850715.1 CDS bcpB NC_010612.1 2909174 2909632 R peroxide detoxification; peroxidoxin BcpB complement(2909174..2909632) Mycobacterium marinum M 6226675 YP_001850716.1 CDS trpE NC_010612.1 2909683 2911221 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 2909683..2911221 Mycobacterium marinum M 6226676 YP_001850717.1 CDS MMAR_2412 NC_010612.1 2911262 2911909 D hypothetical protein 2911262..2911909 Mycobacterium marinum M 6226677 YP_001850718.1 CDS trpC NC_010612.1 2911999 2912817 D involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 2911999..2912817 Mycobacterium marinum M 6226678 YP_001850719.1 CDS trpB NC_010612.1 2912853 2914130 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2912853..2914130 Mycobacterium marinum M 6226679 YP_001850720.1 CDS trpA NC_010612.1 2914133 2914942 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 2914133..2914942 Mycobacterium marinum M 6226680 YP_001850721.1 CDS lgt NC_010612.1 2914939 2917083 D prolipoprotein modification; prolipoprotein diacylglyceryl transferases Lgt 2914939..2917083 Mycobacterium marinum M 6226681 YP_001850722.1 CDS MMAR_2417 NC_010612.1 2917147 2917542 D hypothetical protein 2917147..2917542 Mycobacterium marinum M 6226682 YP_001850723.1 CDS MMAR_2418 NC_010612.1 2917529 2917972 D hypothetical protein 2917529..2917972 Mycobacterium marinum M 6226683 YP_001850724.1 CDS cut1 NC_010612.1 2917994 2918749 R hydrolysis of cutin; cutinase Cut1 complement(2917994..2918749) Mycobacterium marinum M 6226684 YP_001850725.1 CDS pykA NC_010612.1 2919156 2920574 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2919156..2920574 Mycobacterium marinum M 6226685 YP_001850726.1 CDS tesB1 NC_010612.1 2920674 2921579 D involved in fatty acid metabolism; acyl-CoA thioesterase II TesB1 2920674..2921579 Mycobacterium marinum M 6226686 YP_001850727.1 CDS MMAR_2422 NC_010612.1 2921705 2923111 D hypothetical protein 2921705..2923111 Mycobacterium marinum M 6226687 YP_001850728.1 CDS cydC NC_010612.1 2923073 2924767 R involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration). responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; cytochrome assembly ABC transporter ATP-binding protein CydC complement(2923073..2924767) Mycobacterium marinum M 6226688 YP_001850729.1 CDS cydD NC_010612.1 2924754 2926352 R involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration). responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; cytochrome assembly ABC transporter ATP-binding protein CydD complement(2924754..2926352) Mycobacterium marinum M 6226689 YP_001850730.1 CDS cydB NC_010612.1 2926439 2927479 R involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O]; integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB complement(2926439..2927479) Mycobacterium marinum M 6226690 YP_001850731.1 CDS cydA NC_010612.1 2927527 2928984 R involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O]; integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA complement(2927527..2928984) Mycobacterium marinum M 6226691 YP_001850732.1 CDS MMAR_2427 NC_010612.1 2929088 2929666 R hypothetical protein complement(2929088..2929666) Mycobacterium marinum M 6226692 YP_001850733.1 CDS cya NC_010612.1 2929729 2931069 R involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; membrane-anchored adenylyl cyclase Cya complement(2929729..2931069) Mycobacterium marinum M 6226693 YP_001850734.1 CDS MMAR_2429 NC_010612.1 2931371 2931988 D sensor part of a two-component regulatory system; two-component system transcriptional regulator 2931371..2931988 Mycobacterium marinum M 6226695 YP_001850735.1 CDS MMAR_2430 NC_010612.1 2932033 2933235 R thought to be involved in lipid metabolism; lipid-transfer protein complement(2932033..2933235) Mycobacterium marinum M 6226696 YP_001850736.1 CDS MMAR_2431 NC_010612.1 2933235 2933675 R hypothetical protein complement(2933235..2933675) Mycobacterium marinum M 6226697 YP_001850737.1 CDS polA NC_010612.1 2933779 2936478 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 2933779..2936478 Mycobacterium marinum M 6226698 YP_001850738.1 CDS rpsA NC_010612.1 2936859 2938304 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 2936859..2938304 Mycobacterium marinum M 6226699 YP_001850739.1 CDS coaE NC_010612.1 2938317 2939543 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 2938317..2939543 Mycobacterium marinum M 6226700 YP_001850740.1 CDS MMAR_2435 NC_010612.1 2939661 2940197 R hypothetical protein complement(2939661..2940197) Mycobacterium marinum M 6226701 YP_001850741.1 CDS MMAR_2436 NC_010612.1 2940260 2940736 R hypothetical protein complement(2940260..2940736) Mycobacterium marinum M 6226702 YP_001850742.1 CDS uvrB NC_010612.1 2940886 2943066 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 2940886..2943066 Mycobacterium marinum M 6226703 YP_001850743.1 CDS MMAR_2438 NC_010612.1 2943103 2944515 D thought to be involved in transport of drug across the membrane (export). drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells); drug efflux membrane protein 2943103..2944515 Mycobacterium marinum M 6226704 YP_001850744.1 CDS MMAR_2439 NC_010612.1 2944504 2946219 R transmembrane protein complement(2944504..2946219) Mycobacterium marinum M 6226705 YP_001850745.1 CDS MMAR_2440 NC_010612.1 2946394 2946834 D function unknown, domain identity to universal stress protein family and to iron-regulated conserved hypothetical protein TB15.3 from M. tuberculosis H37Rv; iron-regulated protein 2946394..2946834 Mycobacterium marinum M 6226706 YP_001850746.1 CDS MMAR_2441 NC_010612.1 2947202 2947594 D hypothetical protein 2947202..2947594 Mycobacterium marinum M 6226707 YP_001850747.1 CDS MMAR_2442 NC_010612.1 2947714 2948391 R hypothetical protein complement(2947714..2948391) Mycobacterium marinum M 6226708 YP_001850748.1 CDS uvrA NC_010612.1 2948587 2951502 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 2948587..2951502 Mycobacterium marinum M 6226709 YP_001850749.1 CDS MMAR_2444 NC_010612.1 2951551 2953233 R involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase complement(2951551..2953233) Mycobacterium marinum M 6226710 YP_001850750.1 CDS MMAR_2445 NC_010612.1 2953226 2953480 R hypothetical protein complement(2953226..2953480) Mycobacterium marinum M 6226711 YP_001850751.1 CDS MMAR_2446 NC_010612.1 2953617 2955044 R hypothetical protein complement(2953617..2955044) Mycobacterium marinum M 6226712 YP_001850752.1 CDS lysS NC_010612.1 2955106 2958399 R catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase complement(2955106..2958399) Mycobacterium marinum M 6226713 YP_001850753.1 CDS infC NC_010612.1 2958937 2959440 D IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins; initiation factor IF-3 InfC 2958937..2959440 Mycobacterium marinum M 6226714 YP_001850754.1 CDS rpmI NC_010612.1 2959471 2959665 D translation; 50S ribosomal protein L35 2959471..2959665 Mycobacterium marinum M 6226715 YP_001850755.1 CDS rplT NC_010612.1 2959736 2960125 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 2959736..2960125 Mycobacterium marinum M 6226716 YP_001850756.1 CDS tsnR NC_010612.1 2960203 2961030 D rRNA modification; 23S rRNA methyltransferase TsnR 2960203..2961030 Mycobacterium marinum M 6226717 YP_001850757.1 CDS MMAR_2452 NC_010612.1 2961034 2962074 R hypothetical protein complement(2961034..2962074) Mycobacterium marinum M 6226718 YP_001850758.1 CDS MMAR_2453 NC_010612.1 2962428 2963369 D PE family protein 2962428..2963369 Mycobacterium marinum M 6226719 YP_001850759.1 CDS MMAR_2454 NC_010612.1 2963444 2964391 D hypothetical protein 2963444..2964391 Mycobacterium marinum M 6226720 YP_001850760.1 CDS MMAR_2455 NC_010612.1 2964401 2965183 D transmembrane protein 2964401..2965183 Mycobacterium marinum M 6226721 YP_001850761.1 CDS pheS NC_010612.1 2965441 2966484 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 2965441..2966484 Mycobacterium marinum M 6226722 YP_001850762.1 CDS pheT NC_010612.1 2966484 2968973 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 2966484..2968973 Mycobacterium marinum M 6226723 YP_001850763.1 CDS MMAR_2458 NC_010612.1 2969209 2971125 D PE-PGRS family protein 2969209..2971125 Mycobacterium marinum M 6226724 YP_001850764.1 CDS MMAR_2459 NC_010612.1 2971419 2973089 D function unknown; PE-PGRS family protein 2971419..2973089 Mycobacterium marinum M 6226725 YP_001850765.1 CDS MMAR_2460 NC_010612.1 2973346 2975190 D function unknown; PE-PGRS family protein 2973346..2975190 Mycobacterium marinum M 6226726 YP_001850766.1 CDS MMAR_2461 NC_010612.1 2976136 2983359 D PE-PGRS family protein 2976136..2983359 Mycobacterium marinum M 6226727 YP_001850767.1 CDS argC NC_010612.1 2983451 2984503 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 2983451..2984503 Mycobacterium marinum M 6226728 YP_001850768.1 CDS argJ NC_010612.1 2984576 2985790 D bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 2984576..2985790 Mycobacterium marinum M 6226729 YP_001850769.1 CDS argB NC_010612.1 2985787 2986668 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 2985787..2986668 Mycobacterium marinum M 6226730 YP_001850770.1 CDS argD NC_010612.1 2986665 2987855 D catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 2986665..2987855 Mycobacterium marinum M 6226731 YP_001850771.1 CDS argF NC_010612.1 2987852 2988778 D catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 2987852..2988778 Mycobacterium marinum M 6226732 YP_001850772.1 CDS argR NC_010612.1 2988775 2989275 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 2988775..2989275 Mycobacterium marinum M 6226733 YP_001850773.1 CDS argG NC_010612.1 2989324 2990520 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 2989324..2990520 Mycobacterium marinum M 6226734 YP_001850774.1 CDS argH NC_010612.1 2990630 2992042 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 2990630..2992042 Mycobacterium marinum M 6226735 YP_001850775.1 CDS pks10 NC_010612.1 2992146 2993207 D possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]; chalcone synthase, Pks10 2992146..2993207 Mycobacterium marinum M 6226736 YP_001850776.1 CDS pks7 NC_010612.1 2993342 2999704 D Has some homology to Pks12 required for mycoketide syntehsis; polyketide synthase Pks7 2993342..2999704 Mycobacterium marinum M 6226737 YP_001850777.1 CDS pks8 NC_010612.1 2999725 3006069 D function unknown. contains acyl transferase, dehydratase, ketoreductase, and phosphopantetheine attachment site; polyketide synthase 2999725..3006069 Mycobacterium marinum M 6226738 YP_001850778.1 CDS pks9 NC_010612.1 3006075 3009164 D polyketide synthase Pks9 3006075..3009164 Mycobacterium marinum M 6226739 YP_001850779.1 CDS pks11_1 NC_010612.1 3009319 3010380 D possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]; chalcone synthase, Pks11 3009319..3010380 Mycobacterium marinum M 6226740 YP_001850780.1 CDS cyp139A3 NC_010612.1 3010363 3011664 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 139A3 Cyp139A3 complement(3010363..3011664) Mycobacterium marinum M 6226741 YP_001850781.1 CDS MMAR_2476 NC_010612.1 3011661 3013430 R thought to be involved in active transport of macrolide across the membrane (export). macrolide antibiotics resistance by an export mechanism. responsible for energy coupling to the transport system; ABC transporter ATP-binding protein complement(3011661..3013430) Mycobacterium marinum M 6226742 YP_001850782.1 CDS aao_1 NC_010612.1 3014471 3015583 D wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-OXO acid + NH3 + H2O2]; D-amino acid oxidase Aao 3014471..3015583 Mycobacterium marinum M 6226743 YP_001850783.1 CDS MMAR_2478 NC_010612.1 3015733 3018714 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3015733..3018714 Mycobacterium marinum M 6226744 YP_001850784.1 CDS MMAR_2479 NC_010612.1 3018707 3018940 D hypothetical protein 3018707..3018940 Mycobacterium marinum M 6226745 YP_001850785.1 CDS gloA NC_010612.1 3019050 3019487 D role in amino acid transport and metabolism; lactoylglutathione lyase, GloA 3019050..3019487 Mycobacterium marinum M 6226746 YP_001850786.1 CDS MMAR_2481 NC_010612.1 3019673 3021718 R PE-PGRS family protein complement(3019673..3021718) Mycobacterium marinum M 6226747 YP_001850787.1 CDS MMAR_2482 NC_010612.1 3022114 3022737 R hypothetical protein complement(3022114..3022737) Mycobacterium marinum M 6226748 YP_001850788.1 CDS MMAR_2483 NC_010612.1 3022739 3022981 R thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane; antibiotic resistance ABC transporter efflux protein complement(3022739..3022981) Mycobacterium marinum M 6226749 YP_001850789.1 CDS MMAR_2484 NC_010612.1 3023649 3024272 R hypothetical protein complement(3023649..3024272) Mycobacterium marinum M 6226750 YP_001850790.1 CDS MMAR_2485 NC_010612.1 3024274 3024954 R thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane; antibiotic resistance ABC transporter efflux protein complement(3024274..3024954) Mycobacterium marinum M 6226751 YP_001850791.1 CDS MMAR_2486 NC_010612.1 3025026 3025790 R thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for energy coupling to the transport system; antibiotic resistance ABC transporter efflux system, ATP-binding protein complement(3025026..3025790) Mycobacterium marinum M 6226752 YP_001850792.1 CDS mpg NC_010612.1 3025853 3026464 D responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 3025853..3026464 Mycobacterium marinum M 6226753 YP_001850793.1 CDS tyrS NC_010612.1 3026476 3027768 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 3026476..3027768 Mycobacterium marinum M 6226754 YP_001850794.1 CDS MMAR_5562 NC_010612.1 3028074 3028364 D hypothetical protein 3028074..3028364 Mycobacterium marinum M 6226755 YP_001850795.1 CDS MMAR_2489 NC_010612.1 3028598 3029569 R transposition of ISMyma06; transposase for ISMyma06 complement(3028598..3029569) Mycobacterium marinum M 6226756 YP_001850796.1 CDS MMAR_2490 NC_010612.1 3029692 3031554 R PE-PGRS family protein complement(3029692..3031554) Mycobacterium marinum M 6226757 YP_001850797.1 CDS MMAR_2491 NC_010612.1 3031896 3033830 R hypothetical protein complement(3031896..3033830) Mycobacterium marinum M 6226758 YP_001850798.1 CDS MMAR_2492 NC_010612.1 3034269 3036182 R PE-PGRS family protein complement(3034269..3036182) Mycobacterium marinum M 6226759 YP_001850799.1 CDS MMAR_2493 NC_010612.1 3036358 3037869 R hypothetical protein complement(3036358..3037869) Mycobacterium marinum M 6226760 YP_001850800.1 CDS MMAR_2494 NC_010612.1 3037866 3039128 R function unknown; hypothetical protein complement(3037866..3039128) Mycobacterium marinum M 6226761 YP_001850801.1 CDS lprJ NC_010612.1 3039688 3040077 D lipoprotein LprJ 3039688..3040077 Mycobacterium marinum M 6226762 YP_001850802.1 CDS MMAR_2496 NC_010612.1 3040138 3040971 D hypothetical protein 3040138..3040971 Mycobacterium marinum M 6226763 YP_001850803.1 CDS MMAR_2497 NC_010612.1 3040974 3041984 D function unknown; probably involved in cellular metabolism; phosphatase 3040974..3041984 Mycobacterium marinum M 6226764 YP_001850804.1 CDS MMAR_2498 NC_010612.1 3042009 3042185 D hypothetical protein 3042009..3042185 Mycobacterium marinum M 6226765 YP_001850805.1 CDS tlyA NC_010612.1 3042193 3043038 D has a contact-dependent haemolytic activity; possibly involved in virulence (pore formation); cytotoxin/hemolysin, TlyA 3042193..3043038 Mycobacterium marinum M 6226766 YP_001850806.1 CDS ppnK NC_010612.1 3043035 3043958 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 3043035..3043958 Mycobacterium marinum M 6226767 YP_001850807.1 CDS recN NC_010612.1 3043971 3045716 D involved in recombinational repair of damaged DNA; DNA repair protein RecN 3043971..3045716 Mycobacterium marinum M 6226768 YP_001850808.1 CDS MMAR_2502 NC_010612.1 3045882 3047063 D hypothetical protein 3045882..3047063 Mycobacterium marinum M 6226769 YP_001850809.1 CDS MMAR_2503 NC_010612.1 3047085 3048038 D hypothetical protein 3047085..3048038 Mycobacterium marinum M 6226770 YP_001850810.1 CDS pyrG NC_010612.1 3048176 3049927 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3048176..3049927 Mycobacterium marinum M 6226771 YP_001850811.1 CDS MMAR_2505 NC_010612.1 3049920 3050543 D NUDIX hydrolases catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives; NUDIX hydrolase 3049920..3050543 Mycobacterium marinum M 6226772 YP_001850812.1 CDS xerD NC_010612.1 3050540 3051481 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3050540..3051481 Mycobacterium marinum M 6226773 YP_001850813.1 CDS MMAR_2507 NC_010612.1 3051488 3052240 R catalyzes the O-methylation [catalytic activity: S- adenosyl-L-methionine + catechol = S-adenosyl-L- homocysteine + guaiacol]; O-methyltransferase complement(3051488..3052240) Mycobacterium marinum M 6226774 YP_001850814.1 CDS MMAR_2508 NC_010612.1 3052400 3053626 D this is a family of myo-inositol-1-phosphate synthases. inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. inositol phosphates play an important role in signal transduction; myo-inositol-1-phosphate synthase 3052400..3053626 Mycobacterium marinum M 6226775 YP_001850815.1 CDS MMAR_2509 NC_010612.1 3053623 3054486 D membrane associated. contains Cdd matches to polyprenyltransferase domains; transferase 3053623..3054486 Mycobacterium marinum M 6226776 YP_001850816.1 CDS MMAR_2510 NC_010612.1 3054486 3055907 D contains Cdd COG1082,sugar phosphate isomerases/epimerases [carbohydrate transport and metabolism; sugar phosphate isomerase/epimerase 3054486..3055907 Mycobacterium marinum M 6226777 YP_001850817.1 CDS MMAR_2511 NC_010612.1 3055904 3056755 D contains Cdd COG1099, predicted metal-dependent hydrolases with the TIM-barrel FolD; metal dependent hydrolase 3055904..3056755 Mycobacterium marinum M 6226778 YP_001850818.1 CDS MMAR_2512 NC_010612.1 3056752 3057873 D function unknown; closest homologue NP_627450.1 hypothetical (41%ID over 169aa, expect = 3e-24) protein streptomyces coelicolor A3(2) (C-terminal); hypothetical protein 3056752..3057873 Mycobacterium marinum M 6226779 YP_001850819.1 CDS MMAR_2513 NC_010612.1 3057870 3059249 D function unknown; hypothetical protein 3057870..3059249 Mycobacterium marinum M 6226780 YP_001850820.1 CDS MMAR_2514 NC_010612.1 3059350 3060366 D hypothetical protein 3059350..3060366 Mycobacterium marinum M 6226781 YP_001850821.1 CDS MMAR_2515 NC_010612.1 3060387 3061976 R translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane drug efflux protein complement(3060387..3061976) Mycobacterium marinum M 6226782 YP_001850822.1 CDS MMAR_2516 NC_010612.1 3062118 3063296 R PPE family protein complement(3062118..3063296) Mycobacterium marinum M 6226783 YP_001850823.1 CDS MMAR_2517 NC_010612.1 3063528 3064841 R PPE family protein complement(3063528..3064841) Mycobacterium marinum M 6226784 YP_001850824.1 CDS MMAR_2518 NC_010612.1 3065269 3073692 R production of unknown metabolite - contains two modules of: C, a (Phe) , T, E and C, a (arg),T, int te; non-ribosomal peptide synthetase complement(3065269..3073692) Mycobacterium marinum M 6226785 YP_001850825.1 CDS mbtH_2 NC_010612.1 3073741 3073971 R thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; protein MbtH_2 complement(3073741..3073971) Mycobacterium marinum M 6226786 YP_001850826.1 CDS MMAR_2520 NC_010612.1 3073992 3075215 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase complement(3073992..3075215) Mycobacterium marinum M 6226787 YP_001850827.1 CDS MMAR_2521 NC_010612.1 3075222 3075644 R hypothetical protein complement(3075222..3075644) Mycobacterium marinum M 6226788 YP_001850828.1 CDS MMAR_2522 NC_010612.1 3076470 3077132 D hypothetical protein 3076470..3077132 Mycobacterium marinum M 6226789 YP_001850829.1 CDS MMAR_2523 NC_010612.1 3077213 3078169 D function unknown, possible role in chromosome partioning; Soj family ATPase 3077213..3078169 Mycobacterium marinum M 6226790 YP_001850830.1 CDS MMAR_2524 NC_010612.1 3078166 3078993 D hypothetical protein 3078166..3078993 Mycobacterium marinum M 6226791 YP_001850831.1 CDS MMAR_2525 NC_010612.1 3078993 3079700 D transcriptional regulator 3078993..3079700 Mycobacterium marinum M 6226792 YP_001850832.1 CDS MMAR_2526 NC_010612.1 3079700 3080461 D possible role in ribosome biogenesis and protein translation; pseudouridylate synthase 3079700..3080461 Mycobacterium marinum M 6226793 YP_001850833.1 CDS cmk NC_010612.1 3080502 3081260 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 3080502..3081260 Mycobacterium marinum M 6226794 YP_001850834.1 CDS engA NC_010612.1 3081257 3082666 D synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 3081257..3082666 Mycobacterium marinum M 6226795 YP_001850835.1 CDS MMAR_2531 NC_010612.1 3084593 3084916 D transposition of ISMyma03; transposase, ISMyma03_aa1 3084593..3084916 Mycobacterium marinum M 6226799 YP_001850836.1 CDS MMAR_2532 NC_010612.1 3085003 3085866 D transposition of ISMyma03; transposase, ISMyma03_aa2 3085003..3085866 Mycobacterium marinum M 6226800 YP_001850837.1 CDS MMAR_2533 NC_010612.1 3086295 3086723 D hypothetical protein 3086295..3086723 Mycobacterium marinum M 6226801 YP_001850838.1 CDS MMAR_2534 NC_010612.1 3086939 3088153 R function unknown. possibly a protective antigen involved with the early control of infection; PPE family protein complement(3086939..3088153) Mycobacterium marinum M 6226802 YP_001850839.1 CDS MMAR_2535 NC_010612.1 3088681 3089301 R hypothetical protein complement(3088681..3089301) Mycobacterium marinum M 6226803 YP_001850840.1 CDS MMAR_2536 NC_010612.1 3089369 3091663 R metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase complement(3089369..3091663) Mycobacterium marinum M 6226804 YP_001850841.1 CDS MMAR_2537 NC_010612.1 3091725 3092030 R hypothetical protein complement(3091725..3092030) Mycobacterium marinum M 6226805 YP_001850842.1 CDS MMAR_2538 NC_010612.1 3092090 3092698 R hypothetical protein complement(3092090..3092698) Mycobacterium marinum M 6226806 YP_001850843.1 CDS MMAR_2539 NC_010612.1 3092729 3093754 D function unknown, contains six NHL repeats. the NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. it is about 40 residues long and resembles the wd repeat pfam00400. the repeats may have a catalytic activity, proteolysis of one menber has shown that the peptidyl-alpha-hydroxyglycine alpha-amidating lyase (pal) activity is localised to the repeats. one member interacts with the activation domain of tat. this interaction is mediated by the NHL repeats; hypothetical protein 3092729..3093754 Mycobacterium marinum M 6226807 YP_001850844.1 CDS MMAR_2541 NC_010612.1 3094179 3094943 D hypothetical protein 3094179..3094943 Mycobacterium marinum M 6226809 YP_001850845.1 CDS MMAR_2542 NC_010612.1 3094924 3095475 R hypothetical protein complement(3094924..3095475) Mycobacterium marinum M 6226810 YP_001850846.1 CDS MMAR_2543 NC_010612.1 3095940 3097043 D hypothetical protein 3095940..3097043 Mycobacterium marinum M 6226811 YP_001850847.1 CDS MMAR_2545 NC_010612.1 3097429 3097827 D hypothetical protein 3097429..3097827 Mycobacterium marinum M 6226813 YP_001850848.1 CDS MMAR_2546 NC_010612.1 3097923 3098735 R function unknown; domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide; hypothetical protein complement(3097923..3098735) Mycobacterium marinum M 6226814 YP_001850849.1 CDS MMAR_2547 NC_010612.1 3098734 3099057 D transposition of ISMyma03; transposase, ISMyma03_aa1 3098734..3099057 Mycobacterium marinum M 6226815 YP_001850850.1 CDS MMAR_2548 NC_010612.1 3099144 3100007 D transposition of ISMyma03; transposase, ISMyma03_aa2 3099144..3100007 Mycobacterium marinum M 6226816 YP_001850851.1 CDS MMAR_2549 NC_010612.1 3100047 3100499 D hypothetical protein 3100047..3100499 Mycobacterium marinum M 6226817 YP_001850852.1 CDS MMAR_2550 NC_010612.1 3100804 3102099 D transmembrane protein 3100804..3102099 Mycobacterium marinum M 6226818 YP_001850853.1 CDS MMAR_2551 NC_010612.1 3102387 3104339 D PE-PGRS family protein 3102387..3104339 Mycobacterium marinum M 6226819 YP_001850854.1 CDS MMAR_2552 NC_010612.1 3104422 3105213 R this CDS encodes a 3-oxo-5-alpha-steroid 4- dehydrogenase. this family consists of 3-oxo-5-alpha- steroid 4-dehydrogenases. also known as steroid 5-alpha- reductase, the reaction catalysed by this enzyme is: 3-oxo- 5-alpha-steroid + acceptor <=> 3; hypothetical protein complement(3104422..3105213) Mycobacterium marinum M 6226820 YP_001850855.1 CDS MMAR_2553 NC_010612.1 3105433 3105702 R hypothetical protein complement(3105433..3105702) Mycobacterium marinum M 6226821 YP_001850856.1 CDS MMAR_2554 NC_010612.1 3105762 3106097 R hypothetical protein complement(3105762..3106097) Mycobacterium marinum M 6226822 YP_001850857.1 CDS MMAR_2555 NC_010612.1 3106285 3106929 R hypothetical protein complement(3106285..3106929) Mycobacterium marinum M 6226823 YP_001850858.1 CDS MMAR_2557 NC_010612.1 3107269 3108420 D function unknown role in carbohydrate transport and metabolism; aldose 1-epimerase 3107269..3108420 Mycobacterium marinum M 6226825 YP_001850859.1 CDS MMAR_2558 NC_010612.1 3108381 3109187 R hypothetical protein complement(3108381..3109187) Mycobacterium marinum M 6226826 YP_001850860.1 CDS MMAR_2559 NC_010612.1 3109248 3110270 R oxidoreductase complement(3109248..3110270) Mycobacterium marinum M 6226827 YP_001850861.1 CDS MMAR_2560 NC_010612.1 3110279 3111091 R involved in transcriptional mechanism; GntR family transcriptional regulator complement(3110279..3111091) Mycobacterium marinum M 6226828 YP_001850862.1 CDS MMAR_2561 NC_010612.1 3111267 3111593 D hypothetical protein 3111267..3111593 Mycobacterium marinum M 6226829 YP_001850863.1 CDS MMAR_2562 NC_010612.1 3111583 3112524 R hypothetical protein complement(3111583..3112524) Mycobacterium marinum M 6226830 YP_001850864.1 CDS MMAR_2563 NC_010612.1 3112579 3112974 R function unknown but may be involved in inhibition of protein synthesis by cleavage of mRNA; translation initiation inhibitor complement(3112579..3112974) Mycobacterium marinum M 6226831 YP_001850865.1 CDS idsB NC_010612.1 3113519 3114505 D involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of; polyprenyl synthetase IdsB 3113519..3114505 Mycobacterium marinum M 6226832 YP_001850866.1 CDS MMAR_2565 NC_010612.1 3114505 3115860 D hypothetical protein 3114505..3115860 Mycobacterium marinum M 6226833 YP_001850867.1 CDS MMAR_2566 NC_010612.1 3115902 3116774 R function unknown, probably involved in cellular metabolism; hydrolase complement(3115902..3116774) Mycobacterium marinum M 6226834 YP_001850868.1 CDS MMAR_2567 NC_010612.1 3116960 3117268 D hypothetical protein 3116960..3117268 Mycobacterium marinum M 6226835 YP_001850869.1 CDS MMAR_2568 NC_010612.1 3117473 3119989 R the members of this family catalyse the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin; carbohydrate phosphorylase complement(3117473..3119989) Mycobacterium marinum M 6226836 YP_001850870.1 CDS MMAR_2569 NC_010612.1 3120125 3120802 R function unknown but contains signal peptide; hypothetical protein complement(3120125..3120802) Mycobacterium marinum M 6226837 YP_001850871.1 CDS MMAR_2570 NC_010612.1 3121055 3122041 D function unknown but domain identity with penicillin V acylase and related amidases; hydrolase/amidase 3121055..3122041 Mycobacterium marinum M 6226838 YP_001850872.1 CDS gabD2 NC_010612.1 3122210 3123766 D NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 3122210..3123766 Mycobacterium marinum M 6226839 YP_001850873.1 CDS MMAR_2572 NC_010612.1 3123770 3124957 R function unknown but contains signal peptide and domain identity with periplasmic component of the tol biopolymer transport system; hypothetical protein complement(3123770..3124957) Mycobacterium marinum M 6226840 YP_001850874.1 CDS MMAR_2573 NC_010612.1 3125259 3126119 R hypothetical protein complement(3125259..3126119) Mycobacterium marinum M 6226841 YP_001850875.1 CDS MMAR_2574 NC_010612.1 3126382 3127893 D involved in active transport of unknown sugars across the membrane. responsible for the translocation of the substrate across the membrane; sugar transporter 3126382..3127893 Mycobacterium marinum M 6226842 YP_001850876.1 CDS MMAR_2575 NC_010612.1 3128024 3129445 D function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein 3128024..3129445 Mycobacterium marinum M 6226843 YP_001850877.1 CDS pknK NC_010612.1 3129490 3132819 R involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase transcriptional regulatory protein PknK complement(3129490..3132819) Mycobacterium marinum M 6226844 YP_001850878.1 CDS MMAR_2577 NC_010612.1 3132920 3133291 R hypothetical protein complement(3132920..3133291) Mycobacterium marinum M 6226845 YP_001850879.1 CDS MMAR_2578 NC_010612.1 3133636 3136092 D metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporter p-type ATPase a, CtpF 3133636..3136092 Mycobacterium marinum M 6226846 YP_001850880.1 CDS potE NC_010612.1 3136089 3137456 D thought to be involved in transport amino acids across the membrane; amino acid transporter PotE 3136089..3137456 Mycobacterium marinum M 6226847 YP_001850881.1 CDS MMAR_2580 NC_010612.1 3137549 3138286 D hypothetical protein 3137549..3138286 Mycobacterium marinum M 6226848 YP_001850882.1 CDS pknE NC_010612.1 3138515 3140341 D involved in signal transduction (via phosphorylation). thought to be involved in membrane transport [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 3138515..3140341 Mycobacterium marinum M 6226849 YP_001850883.1 CDS MMAR_2582 NC_010612.1 3140411 3141766 D hypothetical protein 3140411..3141766 Mycobacterium marinum M 6226850 YP_001850884.1 CDS MMAR_2583 NC_010612.1 3141776 3143272 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(3141776..3143272) Mycobacterium marinum M 6226851 YP_001850885.1 CDS ceoC1 NC_010612.1 3143519 3144241 D part of a potassium transport system; TRK system potassium uptake protein CeoC1 3143519..3144241 Mycobacterium marinum M 6226852 YP_001850886.1 CDS tex NC_010612.1 3144311 3146674 D function unknown but may play a role in protein translation; transcriptional accessory protein Tex 3144311..3146674 Mycobacterium marinum M 6226853 YP_001850887.1 CDS MMAR_2586 NC_010612.1 3146890 3148359 D function unknown but contains signal peptide; hypothetical protein 3146890..3148359 Mycobacterium marinum M 6226854 YP_001850888.1 CDS ndh1 NC_010612.1 3148368 3149492 R transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation; NADH dehydrogenase Ndh1 complement(3148368..3149492) Mycobacterium marinum M 6226855 YP_001850889.1 CDS MMAR_2588 NC_010612.1 3149489 3150376 R hypothetical protein complement(3149489..3150376) Mycobacterium marinum M 6226856 YP_001850890.1 CDS MMAR_2589 NC_010612.1 3150640 3151332 R involved in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds seven more isoprene units to omega,E, Z- farnesyl diphosphate and releases decaprenyl diphosphate; Z-decaprenyl diphosphate synthase complement(3150640..3151332) Mycobacterium marinum M 6226857 YP_001850891.1 CDS MMAR_2590 NC_010612.1 3151815 3152681 R hypothetical protein complement(3151815..3152681) Mycobacterium marinum M 6226858 YP_001850892.1 CDS MMAR_2591 NC_010612.1 3153310 3159585 D PPE family protein 3153310..3159585 Mycobacterium marinum M 6226859 YP_001850893.1 CDS MMAR_2592 NC_010612.1 3159606 3160442 R short chain dehydrogenase complement(3159606..3160442) Mycobacterium marinum M 6226860 YP_001850894.1 CDS MMAR_2593 NC_010612.1 3160614 3161909 D H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane; divalent cation-transport integral membrane protein 3160614..3161909 Mycobacterium marinum M 6226861 YP_001850895.1 CDS MMAR_2594 NC_010612.1 3161925 3162683 R hypothetical protein complement(3161925..3162683) Mycobacterium marinum M 6226862 YP_001850896.1 CDS MMAR_2595 NC_010612.1 3162734 3163861 R hypothetical protein complement(3162734..3163861) Mycobacterium marinum M 6226863 YP_001850897.1 CDS MMAR_2596 NC_010612.1 3164212 3165732 D PE-PGRS family protein 3164212..3165732 Mycobacterium marinum M 6226864 YP_001850898.1 CDS fadD13 NC_010612.1 3165755 3167263 R function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD13 complement(3165755..3167263) Mycobacterium marinum M 6226865 YP_001850899.1 CDS MMAR_2598 NC_010612.1 3167302 3168720 R hypothetical protein complement(3167302..3168720) Mycobacterium marinum M 6226866 YP_001850900.1 CDS MMAR_2599 NC_010612.1 3168717 3170156 R hypothetical protein complement(3168717..3170156) Mycobacterium marinum M 6226867 YP_001850901.1 CDS MMAR_2600 NC_010612.1 3170153 3171001 R possibly involved in detoxification reactions following oxidative damage to lipids; short-chain dehydrogenase complement(3170153..3171001) Mycobacterium marinum M 6226868 YP_001850902.1 CDS MMAR_2601 NC_010612.1 3171104 3172390 D domain: regulator of polyketide synthase expression; hypothetical protein 3171104..3172390 Mycobacterium marinum M 6226869 YP_001850903.1 CDS MMAR_2602 NC_010612.1 3172514 3172981 D hypothetical protein 3172514..3172981 Mycobacterium marinum M 6226870 YP_001850904.1 CDS MMAR_2603 NC_010612.1 3172985 3173368 D hypothetical protein 3172985..3173368 Mycobacterium marinum M 6226871 YP_001850905.1 CDS MMAR_2604 NC_010612.1 3173588 3175048 D involved in transport of unknown substrate across the membrane; hypothetical protein 3173588..3175048 Mycobacterium marinum M 6226872 YP_001850906.1 CDS MMAR_2605 NC_010612.1 3175058 3177280 D function unknown; probably involved in cellular metabolism; anaerobic dehydrogenase 3175058..3177280 Mycobacterium marinum M 6226873 YP_001850907.1 CDS pknF_3 NC_010612.1 3177417 3178847 D involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr-protein kinase 3177417..3178847 Mycobacterium marinum M 6226874 YP_001850908.1 CDS MMAR_2607 NC_010612.1 3178876 3179223 R hypothetical protein complement(3178876..3179223) Mycobacterium marinum M 6226875 YP_001850909.1 CDS tynA NC_010612.1 3179536 3181482 D catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine; tyramine oxidase 3179536..3181482 Mycobacterium marinum M 6226876 YP_001850910.1 CDS MMAR_2609 NC_010612.1 3181483 3183132 D function unknown. possibly transporter involved in transport of undeterminated substrate (possibly cationic amino acids) across the membrane: so responsible for the translocation of the substrate across the membrane; hypothetical protein 3181483..3183132 Mycobacterium marinum M 6226877 YP_001850911.1 CDS MMAR_2610 NC_010612.1 3183157 3184602 D interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]. this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor; aldehyde dehydrogenase 3183157..3184602 Mycobacterium marinum M 6226878 YP_001850912.1 CDS MMAR_2611 NC_010612.1 3184660 3185985 R hypothetical protein complement(3184660..3185985) Mycobacterium marinum M 6226879 YP_001850913.1 CDS MMAR_2612 NC_010612.1 3186126 3188759 D thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 3186126..3188759 Mycobacterium marinum M 6226880 YP_001850914.1 CDS MMAR_2613 NC_010612.1 3188793 3189308 R hypothetical protein complement(3188793..3189308) Mycobacterium marinum M 6226881 YP_001850915.1 CDS MMAR_2614 NC_010612.1 3189379 3190320 R function unknown but some domain identity with Zn- dependent proteases; hypothetical protein complement(3189379..3190320) Mycobacterium marinum M 6226882 YP_001850916.1 CDS MMAR_2615 NC_010612.1 3190465 3190995 R acetyltransferase complement(3190465..3190995) Mycobacterium marinum M 6226883 YP_001850917.1 CDS MMAR_2616 NC_010612.1 3191218 3192864 D function unknown but domain identity suggests this CDS is Acs-like, acyl-coenzyme A synthetases/AMP-(fatty) acid ligases involved in lipid metabolism; hypothetical protein 3191218..3192864 Mycobacterium marinum M 6226884 YP_001850918.1 CDS araD NC_010612.1 3192851 3193624 D domain identity suggests this CDS encodes an AraD- like, ribulose-5-phosphate 4-epimerase. this enzyme and related epimerases and aldolases are involved in carbohydrate transport and metabolism; ribulose-5-phosphate 4-epimerase, AraD 3192851..3193624 Mycobacterium marinum M 6226885 YP_001850919.1 CDS MMAR_2618 NC_010612.1 3193672 3194940 D function unknown role in cellular metabolism; amidohydrolase 3193672..3194940 Mycobacterium marinum M 6226886 YP_001850920.1 CDS MMAR_2619 NC_010612.1 3195109 3196080 D transposase for ISMyma06 3195109..3196080 Mycobacterium marinum M 6226887 YP_001850921.1 CDS MMAR_2620 NC_010612.1 3196077 3196493 R function unknown but domain identity suggests it may be a signal-transduction protein; hypothetical protein complement(3196077..3196493) Mycobacterium marinum M 6226888 YP_001850922.1 CDS MMAR_2621 NC_010612.1 3196661 3197611 D function unknown, lipolytic enzyme probably involved in cellular metabolism; esterase/lipase 3196661..3197611 Mycobacterium marinum M 6226889 YP_001850923.1 CDS MMAR_2622 NC_010612.1 3197608 3199587 R function unknown; involved in cellular metabolism; flavin-binding monooxygenase complement(3197608..3199587) Mycobacterium marinum M 6226890 YP_001850924.1 CDS MMAR_2623 NC_010612.1 3199828 3200625 D function unknown, probably involved in cellular metabolism; short-chain dehydrogenase 3199828..3200625 Mycobacterium marinum M 6226891 YP_001850925.1 CDS MMAR_2624 NC_010612.1 3200685 3201362 D hypothetical protein 3200685..3201362 Mycobacterium marinum M 6226892 YP_001850926.1 CDS fadD1 NC_010612.1 3201387 3202979 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3201387..3202979) Mycobacterium marinum M 6226893 YP_001850927.1 CDS MMAR_2626 NC_010612.1 3203406 3205136 D hypothetical protein 3203406..3205136 Mycobacterium marinum M 6226894 YP_001850928.1 CDS MMAR_2627 NC_010612.1 3205581 3206810 D function unknown; probably involved in cellular metabolism; hypothetical protein 3205581..3206810 Mycobacterium marinum M 6226895 YP_001850929.1 CDS MMAR_2628 NC_010612.1 3206855 3207853 D hypothetical protein 3206855..3207853 Mycobacterium marinum M 6226896 YP_001850930.1 CDS MMAR_2629 NC_010612.1 3208470 3209621 R glycosyl transferase family protein complement(3208470..3209621) Mycobacterium marinum M 6226897 YP_001850931.1 CDS MMAR_2630 NC_010612.1 3209724 3210593 R function unknown but contains signal peptide; hypothetical protein complement(3209724..3210593) Mycobacterium marinum M 6226898 YP_001850932.1 CDS cyp143A3 NC_010612.1 3210646 3211818 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 143A3 Cyp143A3 complement(3210646..3211818) Mycobacterium marinum M 6226899 YP_001850933.1 CDS MMAR_2632 NC_010612.1 3211980 3212600 R function unknown - contains signal peptide; hypothetical protein complement(3211980..3212600) Mycobacterium marinum M 6226900 YP_001850934.1 CDS MMAR_2633 NC_010612.1 3212830 3213723 D short-chain type dehydrogenase/reductase 3212830..3213723 Mycobacterium marinum M 6226901 YP_001850935.1 CDS MMAR_2634 NC_010612.1 3214051 3215445 D hypothetical protein 3214051..3215445 Mycobacterium marinum M 6226902 YP_001850936.1 CDS MMAR_2635 NC_010612.1 3215591 3216376 D hypothetical protein 3215591..3216376 Mycobacterium marinum M 6226903 YP_001850937.1 CDS MMAR_2636 NC_010612.1 3216376 3216759 D hypothetical protein 3216376..3216759 Mycobacterium marinum M 6226904 YP_001850938.1 CDS MMAR_2637 NC_010612.1 3216799 3217257 R hypothetical protein complement(3216799..3217257) Mycobacterium marinum M 6226905 YP_001850939.1 CDS MMAR_2638 NC_010612.1 3217556 3218185 D involved in transcriptional mechanism; AcrR family transcriptional regulator 3217556..3218185 Mycobacterium marinum M 6226906 YP_001850940.1 CDS MMAR_2639 NC_010612.1 3218299 3218946 R hypothetical protein complement(3218299..3218946) Mycobacterium marinum M 6226907 YP_001850941.1 CDS MMAR_2640 NC_010612.1 3219058 3219711 D could cause methylation of unknown substrate; methyltransferase 3219058..3219711 Mycobacterium marinum M 6226908 YP_001850942.1 CDS trxB1_1 NC_010612.1 3219778 3220152 R thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin TrxB1 complement(3219778..3220152) Mycobacterium marinum M 6226909 YP_001850943.1 CDS MMAR_2642 NC_010612.1 3220288 3220557 D hypothetical protein 3220288..3220557 Mycobacterium marinum M 6226910 YP_001850944.1 CDS MMAR_2643 NC_010612.1 3220591 3221016 D hypothetical protein 3220591..3221016 Mycobacterium marinum M 6226911 YP_001850945.1 CDS MMAR_2644 NC_010612.1 3221071 3221433 D hypothetical protein 3221071..3221433 Mycobacterium marinum M 6226912 YP_001850946.1 CDS MMAR_2645 NC_010612.1 3221630 3223507 D function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection; PE-PGRS family protein 3221630..3223507 Mycobacterium marinum M 6226913 YP_001850947.1 CDS MMAR_2646 NC_010612.1 3223666 3224907 D hypothetical protein 3223666..3224907 Mycobacterium marinum M 6226914 YP_001850948.1 CDS MMAR_2647 NC_010612.1 3224975 3226180 D function unknown but contains aminopeptidase domain identity; hypothetical protein 3224975..3226180 Mycobacterium marinum M 6226915 YP_001850949.1 CDS MMAR_2648 NC_010612.1 3226177 3227463 D function unknown, probably involved in cellular metabolism; oxidoreductase 3226177..3227463 Mycobacterium marinum M 6226916 YP_001850950.1 CDS MMAR_2649 NC_010612.1 3227572 3228936 D hypothetical protein 3227572..3228936 Mycobacterium marinum M 6226917 YP_001850951.1 CDS MMAR_2650 NC_010612.1 3229779 3231065 D PPE family protein 3229779..3231065 Mycobacterium marinum M 6226918 YP_001850952.1 CDS MMAR_2651 NC_010612.1 3231405 3231959 R involved in transcriptional mechanism; transcriptional regulatory protein complement(3231405..3231959) Mycobacterium marinum M 6226919 YP_001850953.1 CDS cyp144A4 NC_010612.1 3233144 3234358 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 144A4 Cyp144A4 3233144..3234358 Mycobacterium marinum M 6226922 YP_001850954.1 CDS MMAR_2655 NC_010612.1 3234414 3235013 R involved in transcriptional mechanism; transcriptional regulatory protein complement(3234414..3235013) Mycobacterium marinum M 6226923 YP_001850955.1 CDS MMAR_2656 NC_010612.1 3235425 3241781 D PE-PGRS family protein 3235425..3241781 Mycobacterium marinum M 6226924 YP_001850956.1 CDS MMAR_2657 NC_010612.1 3241796 3242368 R function unknown but this protein family are hydrolase enzymes; isochorismatase family protein complement(3241796..3242368) Mycobacterium marinum M 6226925 YP_001850957.1 CDS MMAR_2659 NC_010612.1 3242602 3243051 R hypothetical protein complement(3242602..3243051) Mycobacterium marinum M 6226926 YP_001850958.1 CDS MMAR_2660 NC_010612.1 3243270 3245102 R hypothetical protein complement(3243270..3245102) Mycobacterium marinum M 6226927 YP_001850959.1 CDS MMAR_2661 NC_010612.1 3245328 3245891 D hypothetical protein 3245328..3245891 Mycobacterium marinum M 6226928 YP_001850960.1 CDS MMAR_2662 NC_010612.1 3246229 3246486 D hypothetical protein 3246229..3246486 Mycobacterium marinum M 6226929 YP_001850961.1 CDS malQ NC_010612.1 3246594 3248765 R transfers a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan; 4-alpha-glucanotransferase complement(3246594..3248765) Mycobacterium marinum M 6226930 YP_001850962.1 CDS MMAR_2664 NC_010612.1 3249090 3250613 D hypothetical protein 3249090..3250613 Mycobacterium marinum M 6226931 YP_001850963.1 CDS MMAR_2665 NC_010612.1 3250610 3254776 D function unknown but has multiple FtsK/SpoIIIE protein domains. this domain contains a putative ATP binding P-loop motif and is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE; FtsK/SpoIIIE family protein 3250610..3254776 Mycobacterium marinum M 6226932 YP_001850964.1 CDS cyp143A4 NC_010612.1 3254808 3255983 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 143A4 Cyp143A4 complement(3254808..3255983) Mycobacterium marinum M 6226933 YP_001850965.1 CDS MMAR_2667 NC_010612.1 3256246 3256440 D ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin 3256246..3256440 Mycobacterium marinum M 6226934 YP_001850966.1 CDS MMAR_2668 NC_010612.1 3256637 3256828 D hypothetical protein 3256637..3256828 Mycobacterium marinum M 6226935 YP_001850967.1 CDS MMAR_2669 NC_010612.1 3256977 3258233 D PPE family protein 3256977..3258233 Mycobacterium marinum M 6226936 YP_001850968.1 CDS MMAR_2670 NC_010612.1 3258432 3258731 D PE family protein 3258432..3258731 Mycobacterium marinum M 6226937 YP_001850969.1 CDS MMAR_2671 NC_010612.1 3258743 3259969 D PPE family protein 3258743..3259969 Mycobacterium marinum M 6226938 YP_001850970.1 CDS MMAR_2672 NC_010612.1 3260043 3260363 D hypothetical protein 3260043..3260363 Mycobacterium marinum M 6226939 YP_001850971.1 CDS MMAR_2673 NC_010612.1 3260928 3261227 D PE family protein 3260928..3261227 Mycobacterium marinum M 6226940 YP_001850972.1 CDS esxM NC_010612.1 3261571 3261867 D EsaT-6 like protein EsxM 3261571..3261867 Mycobacterium marinum M 6226941 YP_001850973.1 CDS esxN NC_010612.1 3261919 3262203 D EsaT-6 like protein EsxN 3261919..3262203 Mycobacterium marinum M 6226942 YP_001850974.1 CDS MMAR_2676 NC_010612.1 3262292 3263194 D hypothetical protein 3262292..3263194 Mycobacterium marinum M 6226943 YP_001850975.1 CDS MMAR_2677 NC_010612.1 3263480 3264991 D hypothetical protein 3263480..3264991 Mycobacterium marinum M 6226944 YP_001850976.1 CDS mycP5 NC_010612.1 3264969 3266711 D function unknown proteolytic activity but subtilases are a family of serine proteases that can play a role in posttranslational modification; proline rich membrane-anchored mycosin MycP5 3264969..3266711 Mycobacterium marinum M 6226945 YP_001850977.1 CDS MMAR_2679 NC_010612.1 3266708 3267919 D hypothetical protein 3266708..3267919 Mycobacterium marinum M 6226946 YP_001850978.1 CDS MMAR_2680 NC_010612.1 3267916 3269748 D function unknown, but domain identity to aaa, ATPase family proteins that have been associated with chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes; hypothetical protein 3267916..3269748 Mycobacterium marinum M 6226947 YP_001850979.1 CDS MMAR_2681 NC_010612.1 3270649 3271917 D PPE family protein 3270649..3271917 Mycobacterium marinum M 6226948 YP_001850980.1 CDS MMAR_2682 NC_010612.1 3272013 3273242 D PPE family protein 3272013..3273242 Mycobacterium marinum M 6226949 YP_001850981.1 CDS MMAR_2683 NC_010612.1 3274083 3275243 D PPE family protein 3274083..3275243 Mycobacterium marinum M 6226950 YP_001850982.1 CDS MMAR_2684 NC_010612.1 3276328 3277608 D PPE family protein 3276328..3277608 Mycobacterium marinum M 6226951 YP_001850983.1 CDS MMAR_2685 NC_010612.1 3277695 3279101 D PPE family protein 3277695..3279101 Mycobacterium marinum M 6226952 YP_001850984.1 CDS MMAR_2686 NC_010612.1 3279402 3279722 D hypothetical protein 3279402..3279722 Mycobacterium marinum M 6226953 YP_001850985.1 CDS mgtC NC_010612.1 3279930 3280658 D thought to be involved in Mg2+ transport (import). may act as an accessory protein for MgtB so mediating magnesium influx into the cytosol [catalytic activity: ATP + H(2)O + mg(2+)(out) = ADP + phosphate + mg(2+)(in)]; Mg2+ transport p-type ATPase C MgtC 3279930..3280658 Mycobacterium marinum M 6226954 YP_001850986.1 CDS MMAR_2688 NC_010612.1 3280660 3281859 R function unknown, probably involved in cellular metabolism; NADH dehydrogenase complement(3280660..3281859) Mycobacterium marinum M 6226955 YP_001850987.1 CDS MMAR_2689 NC_010612.1 3281856 3282017 R function unknown - weak domain identity with lipase/esterase proteins; hypothetical protein complement(3281856..3282017) Mycobacterium marinum M 6226956 YP_001850988.1 CDS MMAR_2690 NC_010612.1 3282019 3282354 R function unknown - weak domain identity with lipase/esterase proteins; hypothetical protein complement(3282019..3282354) Mycobacterium marinum M 6226957 YP_001850989.1 CDS erg3 NC_010612.1 3282658 3283566 D involved in lipid desaturation; membrane-bound C-5 sterol desaturase Erg3 3282658..3283566 Mycobacterium marinum M 6226958 YP_001850990.1 CDS MMAR_2692 NC_010612.1 3283687 3284355 D hypothetical protein 3283687..3284355 Mycobacterium marinum M 6226959 YP_001850991.1 CDS MMAR_2693 NC_010612.1 3284547 3285047 D hypothetical protein 3284547..3285047 Mycobacterium marinum M 6226960 YP_001850992.1 CDS MMAR_2694 NC_010612.1 3285083 3286525 D function unknown, probably involved in cellular metabolism; hypothetical protein 3285083..3286525 Mycobacterium marinum M 6226961 YP_001850993.1 CDS MMAR_2695 NC_010612.1 3286571 3289252 R PE-PGRS family protein complement(3286571..3289252) Mycobacterium marinum M 6226962 YP_001850994.1 CDS MMAR_2696 NC_010612.1 3289819 3291738 R thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; drug-transport transmembrane ABC transporter ATP-binding protein complement(3289819..3291738) Mycobacterium marinum M 6226963 YP_001850995.1 CDS ilvG NC_010612.1 3291842 3293494 D valine and isoleucine biosynthesis (first step) [catalytic activity : 2-acetolactate + CO(2) = 2 pyruvate]; hypothetical protein 3291842..3293494 Mycobacterium marinum M 6226964 YP_001850996.1 CDS secA2 NC_010612.1 3293525 3295945 D SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 3293525..3295945 Mycobacterium marinum M 6226965 YP_001850997.1 CDS pgsA2 NC_010612.1 3296067 3296696 D thought to be involved in cardiolipin biosynthesis; generates cardiolipin from phosphatidylglycerol and CDP- diacylglycerol [catalytic activity : may be: phosphatidylglycerol + phosphatidylglycerol -> cardiolipin + glycerol, or: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate]; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 3296067..3296696 Mycobacterium marinum M 6226966 YP_001850998.1 CDS MMAR_2700 NC_010612.1 3296689 3297609 D hypothetical protein 3296689..3297609 Mycobacterium marinum M 6226967 YP_001850999.1 CDS MMAR_2701 NC_010612.1 3297671 3298003 D hypothetical protein 3297671..3298003 Mycobacterium marinum M 6226968 YP_001851000.1 CDS MMAR_2702 NC_010612.1 3298157 3298918 D hypothetical protein 3298157..3298918 Mycobacterium marinum M 6226969 YP_001851001.1 CDS gcvH NC_010612.1 3298953 3299357 D part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3298953..3299357 Mycobacterium marinum M 6226970 YP_001851002.1 CDS MMAR_2704 NC_010612.1 3299615 3300103 D function unknown but contains an FHA domain. these domains are involved in nuclear signalling domain and may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine; hypothetical protein 3299615..3300103 Mycobacterium marinum M 6226971 YP_001851003.1 CDS MMAR_2705 NC_010612.1 3300100 3300855 D function unknown but high N-terminal domain identity with the MerR helix-turn-helix transcription regulator; putative regulatory protein 3300100..3300855 Mycobacterium marinum M 6226972 YP_001851004.1 CDS MMAR_2706 NC_010612.1 3300996 3301490 D hypothetical protein 3300996..3301490 Mycobacterium marinum M 6226973 YP_001851005.1 CDS MMAR_2707 NC_010612.1 3301702 3302400 D function unknown but contains MerR helix-turn-helix transcription regulatory domain; regulatory protein 3301702..3302400 Mycobacterium marinum M 6226974 YP_001851006.1 CDS gcvB NC_010612.1 3302763 3305600 D acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3302763..3305600 Mycobacterium marinum M 6226975 YP_001851007.1 CDS MMAR_2709 NC_010612.1 3305630 3307195 R PE-PGRS family protein complement(3305630..3307195) Mycobacterium marinum M 6226976 YP_001851008.1 CDS MMAR_2710 NC_010612.1 3307475 3308347 R may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide]; haloalkane dehalogenase complement(3307475..3308347) Mycobacterium marinum M 6226977 YP_001851009.1 CDS MMAR_2711 NC_010612.1 3308397 3309263 D hydrolase 3308397..3309263 Mycobacterium marinum M 6226978 YP_001851010.1 CDS MMAR_2712 NC_010612.1 3309293 3311500 R function unknown but weak C-term identity with vWA domain (von willebrand factor type a domain). this domain is found in extracellular proteins, like integrins, and mediates adhesion; hypothetical protein complement(3309293..3311500) Mycobacterium marinum M 6226979 YP_001851011.1 CDS glcB NC_010612.1 3311551 3313746 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(3311551..3313746) Mycobacterium marinum M 6226980 YP_001851012.1 CDS MMAR_2715 NC_010612.1 3315825 3316877 R hypothetical protein complement(3315825..3316877) Mycobacterium marinum M 6226982 YP_001851013.1 CDS MMAR_2716 NC_010612.1 3316874 3318256 R function unknown - however contains domain identity with TlyC - representative of hemolysins and related proteins containing Cbs domains. Cbs domains are small intracellular modules of unknown function. they are mostly found in 2 or four copies within a protein; hypothetical protein complement(3316874..3318256) Mycobacterium marinum M 6226983 YP_001851014.1 CDS guaB1 NC_010612.1 3318451 3319887 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase complement(3318451..3319887) Mycobacterium marinum M 6226984 YP_001851015.1 CDS gnd1 NC_010612.1 3319919 3321370 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(3319919..3321370) Mycobacterium marinum M 6226985 YP_001851016.1 CDS MMAR_2719 NC_010612.1 3321480 3322430 R function unknown but significant domain identity with HtpX, Zn-dependent protease with chaperone function; hypothetical protein complement(3321480..3322430) Mycobacterium marinum M 6226986 YP_001851017.1 CDS MMAR_2720 NC_010612.1 3322445 3322861 R involved in transcriptional mechanism; transcriptional regulatory protein complement(3322445..3322861) Mycobacterium marinum M 6226987 YP_001851018.1 CDS MMAR_2721 NC_010612.1 3323288 3323728 D function unknown but domain identity suggests possibly involved in aromatic compound catabolism; hypothetical protein 3323288..3323728 Mycobacterium marinum M 6226988 YP_001851019.1 CDS ureA NC_010612.1 3323725 3324090 D UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 3323725..3324090 Mycobacterium marinum M 6226989 YP_001851020.1 CDS ureB NC_010612.1 3324087 3324398 D involved in the conversion of UreA to NH3 [catalytic activity: UreA + H2O = CO2 + 2 NH3]; urease subunit beta UreB 3324087..3324398 Mycobacterium marinum M 6226990 YP_001851021.1 CDS ureC NC_010612.1 3324398 3326131 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 3324398..3326131 Mycobacterium marinum M 6226991 YP_001851022.1 CDS ureF NC_010612.1 3326131 3326766 D required for the insertion of the nickel ion at the active site of the urease protein; urease accessory protein UreF 3326131..3326766 Mycobacterium marinum M 6226992 YP_001851023.1 CDS ureG NC_010612.1 3326777 3327448 D UreG is required for functional incorporation of the urease nickel metallocenter. it is not known whether UreG binds GTP or some other nucleotide; urease accessory protein UreG 3326777..3327448 Mycobacterium marinum M 6226993 YP_001851024.1 CDS ureD NC_010612.1 3327448 3328092 D UreD is involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex and is required for urease nickel metallocenter assembly; urease accessory protein UreD 3327448..3328092 Mycobacterium marinum M 6226994 YP_001851025.1 CDS ndh NC_010612.1 3328163 3329548 R transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation; NADH dehydrogenase Ndh complement(3328163..3329548) Mycobacterium marinum M 6226995 YP_001851026.1 CDS MMAR_2729 NC_010612.1 3329712 3330635 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(3329712..3330635) Mycobacterium marinum M 6226996 YP_001851027.1 CDS MMAR_2730 NC_010612.1 3330686 3331363 R function unknown, probably involved in cellular metabolism; short chain dehydrogenase complement(3330686..3331363) Mycobacterium marinum M 6226997 YP_001851028.1 CDS modA NC_010612.1 3331650 3332414 D involved in the active transport of molybdenum into the cell across the membrane (import). part of the binding- protein-dependent transport system ModABC; molybdate-binding lipoprotein ModA 3331650..3332414 Mycobacterium marinum M 6226998 YP_001851029.1 CDS modB NC_010612.1 3332424 3333218 D part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for the translocation of the substrate across the membrane; molybdenum-transport integral membrane protein ABC transporter ModB 3332424..3333218 Mycobacterium marinum M 6226999 YP_001851030.1 CDS omt NC_010612.1 3333231 3334064 R function unknown, but possible involved in lipid metabolism; O-methyltransferase Omt complement(3333231..3334064) Mycobacterium marinum M 6227000 YP_001851031.1 CDS MMAR_2734 NC_010612.1 3334254 3335711 D function unknown but shows high identity with sulfide-quinone reductase from chlorobium tepidum; hypothetical protein 3334254..3335711 Mycobacterium marinum M 6227001 YP_001851032.1 CDS MMAR_2735 NC_010612.1 3335708 3335908 D hypothetical protein 3335708..3335908 Mycobacterium marinum M 6227002 YP_001851033.1 CDS modC NC_010612.1 3335972 3337213 D part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for energy coupling to the transport system; molybdenum-transport ABC transporter ATP-binding protein ModC 3335972..3337213 Mycobacterium marinum M 6227003 YP_001851034.1 CDS apa NC_010612.1 3337300 3338304 D function unknown could mediate bacterial attachment to host cells; alanine and proline rich secreted protein Apa 3337300..3338304 Mycobacterium marinum M 6227004 YP_001851035.1 CDS MMAR_2738 NC_010612.1 3338460 3338756 D hypothetical protein 3338460..3338756 Mycobacterium marinum M 6227005 YP_001851036.1 CDS adhA NC_010612.1 3338849 3339850 D catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD; alcohol dehydrogenase AdhA 3338849..3339850 Mycobacterium marinum M 6227006 YP_001851037.1 CDS MMAR_2740 NC_010612.1 3339857 3340621 R hypothetical protein complement(3339857..3340621) Mycobacterium marinum M 6227007 YP_001851038.1 CDS MMAR_2741 NC_010612.1 3340918 3341592 R hypothetical protein complement(3340918..3341592) Mycobacterium marinum M 6227008 YP_001851039.1 CDS xfp NC_010612.1 3341817 3344219 R bacterial enzyme that splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-p and/or acetyl-P and glyeraldehyde-3-p; putative phosphoketolase complement(3341817..3344219) Mycobacterium marinum M 6227009 YP_001851040.1 CDS MMAR_2743 NC_010612.1 3344265 3345122 R function unknown, probably involved in cellular metabolism; short chain dehydrogenase complement(3344265..3345122) Mycobacterium marinum M 6227010 YP_001851041.1 CDS MMAR_2744 NC_010612.1 3345230 3345775 D function unknown but contains acetyltransferase domain identity; acetyltransferase 3345230..3345775 Mycobacterium marinum M 6227011 YP_001851042.1 CDS MMAR_2745 NC_010612.1 3345884 3348322 D function unknown, but possible involvement in lipid metabolism; acyl-CoA transferase/dehydratase 3345884..3348322 Mycobacterium marinum M 6227012 YP_001851043.1 CDS MMAR_2746 NC_010612.1 3348408 3349892 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3348408..3349892 Mycobacterium marinum M 6227013 YP_001851044.1 CDS MMAR_2747 NC_010612.1 3350005 3352113 D function unknown but contains nucleoside- diphosphate-sugar epimerase domain identity - a domain associated with cell envelope biogenesis, carbohydrate transport and metabolism; hypothetical protein 3350005..3352113 Mycobacterium marinum M 6227014 YP_001851045.1 CDS MMAR_2748 NC_010612.1 3352215 3352661 R hypothetical protein complement(3352215..3352661) Mycobacterium marinum M 6227015 YP_001851046.1 CDS MMAR_2749 NC_010612.1 3352785 3353117 R hypothetical protein complement(3352785..3353117) Mycobacterium marinum M 6227016 YP_001851047.1 CDS MMAR_2750 NC_010612.1 3353120 3353509 R hypothetical protein complement(3353120..3353509) Mycobacterium marinum M 6227017 YP_001851048.1 CDS lon NC_010612.1 3353614 3355938 R function unknown but probably plays a role in posttranslational protein modification, turnover and chaperone functions; Lon, ATP-dependent Lon protease complement(3353614..3355938) Mycobacterium marinum M 6227018 YP_001851049.1 CDS lldD2 NC_010612.1 3356060 3357304 R involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]; L-lactate dehydrogenase (cytochrome) LldD2 complement(3356060..3357304) Mycobacterium marinum M 6227019 YP_001851050.1 CDS treS_1 NC_010612.1 3357465 3358754 R involved in trehalose biosynthesis (protective effect). converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); trehalose synthase TreS complement(3357465..3358754) Mycobacterium marinum M 6227020 YP_001851051.1 CDS ahpD NC_010612.1 3358783 3359319 R involved in oxidative stress response; alkyl hydroperoxide reductase D protein AhpD complement(3358783..3359319) Mycobacterium marinum M 6227021 YP_001851052.1 CDS ahpC NC_010612.1 3359360 3359947 R involved in oxidative stress response; alkyl hydroperoxide reductase C protein AhpC complement(3359360..3359947) Mycobacterium marinum M 6227022 YP_001851053.1 CDS oxyR NC_010612.1 3360045 3361004 D hydrogen peroxide-inducible genes activator, OxyR 3360045..3361004 Mycobacterium marinum M 6227023 YP_001851054.1 CDS MMAR_2757 NC_010612.1 3361039 3361752 D hypothetical protein 3361039..3361752 Mycobacterium marinum M 6227024 YP_001851055.1 CDS MMAR_2758 NC_010612.1 3361749 3362192 D hypothetical protein 3361749..3362192 Mycobacterium marinum M 6227025 YP_001851056.1 CDS echA8_6 NC_010612.1 3362202 3362960 D oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_6 3362202..3362960 Mycobacterium marinum M 6227026 YP_001851057.1 CDS MMAR_2760 NC_010612.1 3362991 3363167 R function unknown but like upstream ORF, contains bacterioferritin-associated ferredoxin domain; hypothetical protein complement(3362991..3363167) Mycobacterium marinum M 6227027 YP_001851058.1 CDS bfrA NC_010612.1 3363475 3363954 D involved in iron storage (may perform analogous functions in iron detoxification and storage as that of animal ferritins); ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited; bacterioferritin BfrA 3363475..3363954 Mycobacterium marinum M 6227028 YP_001851059.1 CDS MMAR_2762 NC_010612.1 3364396 3364890 D hypothetical protein 3364396..3364890 Mycobacterium marinum M 6227029 YP_001851060.1 CDS glnA3 NC_010612.1 3364930 3366291 D involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]; glutamine synthetase 3364930..3366291 Mycobacterium marinum M 6227030 YP_001851061.1 CDS MMAR_2764 NC_010612.1 3366295 3367449 D hypothetical protein 3366295..3367449 Mycobacterium marinum M 6227031 YP_001851062.1 CDS MMAR_2765 NC_010612.1 3367446 3368852 D function unknown; involved in cellular metabolism; amidase 3367446..3368852 Mycobacterium marinum M 6227032 YP_001851063.1 CDS MMAR_2766 NC_010612.1 3369477 3373943 D involved in lipid metabolism. single module of C, a (Phe or trp), T, C domains; non-ribosomal peptide synthetase 3369477..3373943 Mycobacterium marinum M 6227033 YP_001851064.1 CDS MMAR_2767 NC_010612.1 3374015 3374473 R hypothetical protein complement(3374015..3374473) Mycobacterium marinum M 6227034 YP_001851065.1 CDS cyp140A5 NC_010612.1 3374577 3375893 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 140A5 Cyp140A5 complement(3374577..3375893) Mycobacterium marinum M 6227035 YP_001851066.1 CDS lppE NC_010612.1 3376004 3376426 R lipoprotein LppE complement(3376004..3376426) Mycobacterium marinum M 6227036 YP_001851067.1 CDS MMAR_2770 NC_010612.1 3376468 3377301 R function unknown, probably involved in cellular metabolism; short chain dehydrogenase complement(3376468..3377301) Mycobacterium marinum M 6227037 YP_001851068.1 CDS MMAR_2771 NC_010612.1 3377316 3377750 R hypothetical protein complement(3377316..3377750) Mycobacterium marinum M 6227038 YP_001851069.1 CDS MMAR_2772 NC_010612.1 3377830 3378243 R thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis; resuscitation-promoting factor-like protein complement(3377830..3378243) Mycobacterium marinum M 6227039 YP_001851070.1 CDS MMAR_2773 NC_010612.1 3378362 3378970 R catalyzes the interconversion of chorismate to prephenate; chorismate mutase complement(3378362..3378970) Mycobacterium marinum M 6227040 YP_001851071.1 CDS MMAR_2774 NC_010612.1 3378987 3379832 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(3378987..3379832) Mycobacterium marinum M 6227041 YP_001851072.1 CDS MMAR_2775 NC_010612.1 3379912 3380919 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(3379912..3380919) Mycobacterium marinum M 6227042 YP_001851073.1 CDS MMAR_2776 NC_010612.1 3381042 3381632 D hypothetical protein 3381042..3381632 Mycobacterium marinum M 6227043 YP_001851074.1 CDS fbpB NC_010612.1 3381716 3382693 R involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted antigen 85-B FbpB complement(3381716..3382693) Mycobacterium marinum M 6227044 YP_001851075.1 CDS MMAR_2778 NC_010612.1 3382784 3383335 R hypothetical protein complement(3382784..3383335) Mycobacterium marinum M 6227045 YP_001851076.1 CDS MMAR_2779 NC_010612.1 3383408 3384550 D hypothetical protein 3383408..3384550 Mycobacterium marinum M 6227046 YP_001851077.1 CDS MMAR_2780 NC_010612.1 3384570 3385241 R hypothetical protein complement(3384570..3385241) Mycobacterium marinum M 6227047 YP_001851078.1 CDS MMAR_2781 NC_010612.1 3385416 3386000 R function unknown but some similarity with YceI-like family proteins. in E. coli YceI is a base-induced periplasmic protein. its function has not yet been characterised; hypothetical protein complement(3385416..3386000) Mycobacterium marinum M 6227048 YP_001851079.1 CDS adhC NC_010612.1 3385997 3387010 R generates aldehyde or ketone from alcohol [catalytic activity: alcohol + NADP(+) = aldehyde or ketone + NADPH]; NADP-dependent alcohol dehydrogenase AdhC complement(3385997..3387010) Mycobacterium marinum M 6227049 YP_001851080.1 CDS cyp125A6 NC_010612.1 3387035 3388321 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 125A6 Cyp125A6 complement(3387035..3388321) Mycobacterium marinum M 6227050 YP_001851081.1 CDS MMAR_2784 NC_010612.1 3388775 3389179 D hypothetical protein 3388775..3389179 Mycobacterium marinum M 6227051 YP_001851082.1 CDS MMAR_2785 NC_010612.1 3389197 3389490 D hypothetical protein 3389197..3389490 Mycobacterium marinum M 6227052 YP_001851083.1 CDS MMAR_2786 NC_010612.1 3389564 3389782 D hypothetical protein 3389564..3389782 Mycobacterium marinum M 6227053 YP_001851084.1 CDS MMAR_2787 NC_010612.1 3389833 3390960 R hypothetical protein complement(3389833..3390960) Mycobacterium marinum M 6227054 YP_001851085.1 CDS MMAR_2788 NC_010612.1 3391110 3391571 R hypothetical protein complement(3391110..3391571) Mycobacterium marinum M 6227055 YP_001851086.1 CDS MMAR_2789 NC_010612.1 3391871 3393802 D function unknown; involved in cellular metabolism; monooxygenase 3391871..3393802 Mycobacterium marinum M 6227056 YP_001851087.1 CDS MMAR_2790 NC_010612.1 3393813 3394838 D function unknown, probably involved in cellular metabolism; dehydrogenase 3393813..3394838 Mycobacterium marinum M 6227057 YP_001851088.1 CDS MMAR_2791 NC_010612.1 3394828 3395739 R function unknown but significant domain identity with O-Methyltransferases involved in polyketide biosynthesis; hypothetical protein complement(3394828..3395739) Mycobacterium marinum M 6227058 YP_001851089.1 CDS MMAR_2792 NC_010612.1 3395781 3396212 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(3395781..3396212) Mycobacterium marinum M 6227059 YP_001851090.1 CDS MMAR_2793 NC_010612.1 3396509 3396835 D hypothetical protein 3396509..3396835 Mycobacterium marinum M 6227060 YP_001851091.1 CDS lppD NC_010612.1 3396832 3397326 R Truncated wrt to orthologues, missing last 12aa - potential pseudogene; function unknown but contains predicted phosphatase domain; lipoprotein LppD complement(3396832..3397326) Mycobacterium marinum M 6227061 YP_001851092.1 CDS MMAR_2795 NC_010612.1 3397556 3397861 D PE-PGRS family protein 3397556..3397861 Mycobacterium marinum M 6227062 YP_001851093.1 CDS cinA NC_010612.1 3397978 3399255 D CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation; competence damage-inducible protein A 3397978..3399255 Mycobacterium marinum M 6227063 YP_001851094.1 CDS nanT NC_010612.1 3399351 3400610 R transport of sialic acid across the membrane. responsible for the translocation of the substrate across the membrane; sialic acid-transport integral membrane protein NanT complement(3399351..3400610) Mycobacterium marinum M 6227064 YP_001851095.1 CDS MMAR_2798 NC_010612.1 3400686 3401753 D amidohydrolase 3400686..3401753 Mycobacterium marinum M 6227065 YP_001851096.1 CDS MMAR_2799 NC_010612.1 3401770 3402171 D hypothetical protein 3401770..3402171 Mycobacterium marinum M 6227066 YP_001851097.1 CDS MMAR_2800 NC_010612.1 3402456 3402896 D hypothetical protein 3402456..3402896 Mycobacterium marinum M 6227067 YP_001851098.1 CDS aao NC_010612.1 3402911 3403894 R wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-OXO acid + NH3 + H2O2]; D-amino acid oxidase Aao complement(3402911..3403894) Mycobacterium marinum M 6227068 YP_001851099.1 CDS MMAR_2802 NC_010612.1 3403907 3404425 R hypothetical protein complement(3403907..3404425) Mycobacterium marinum M 6227069 YP_001851100.1 CDS MMAR_2803 NC_010612.1 3404426 3404851 R hypothetical protein complement(3404426..3404851) Mycobacterium marinum M 6227070 YP_001851101.1 CDS MMAR_2804 NC_010612.1 3404839 3405564 R hypothetical protein complement(3404839..3405564) Mycobacterium marinum M 6227071 YP_001851102.1 CDS MMAR_2805 NC_010612.1 3405988 3406425 R hypothetical protein complement(3405988..3406425) Mycobacterium marinum M 6227072 YP_001851103.1 CDS MMAR_2806 NC_010612.1 3406422 3407663 R PPE family protein complement(3406422..3407663) Mycobacterium marinum M 6227073 YP_001851104.1 CDS MMAR_2809 NC_010612.1 3408518 3409150 R hypothetical protein complement(3408518..3409150) Mycobacterium marinum M 6227076 YP_001851105.1 CDS MMAR_2810 NC_010612.1 3409293 3410231 D function unknown; contains putative metal-dependent hydrolase domain; hypothetical protein 3409293..3410231 Mycobacterium marinum M 6227077 YP_001851106.1 CDS MMAR_2811 NC_010612.1 3410231 3411364 D hypothetical protein 3410231..3411364 Mycobacterium marinum M 6227078 YP_001851107.1 CDS MMAR_2812 NC_010612.1 3411751 3412350 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(3411751..3412350) Mycobacterium marinum M 6227079 YP_001851108.1 CDS MMAR_2813 NC_010612.1 3412465 3414045 D function unknown, probably involved in cellular metabolism; dehydrogenase 3412465..3414045 Mycobacterium marinum M 6227080 YP_001851109.1 CDS fadB5 NC_010612.1 3414096 3415100 R thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle; oxidoreductase FadB5 complement(3414096..3415100) Mycobacterium marinum M 6227081 YP_001851110.1 CDS MMAR_2815 NC_010612.1 3415143 3415571 R hypothetical protein complement(3415143..3415571) Mycobacterium marinum M 6227082 YP_001851111.1 CDS MMAR_2816 NC_010612.1 3415568 3415894 R involved in transcriptional regulation; ArsR-type repressor complement(3415568..3415894) Mycobacterium marinum M 6227083 YP_001851112.1 CDS MMAR_2817 NC_010612.1 3415953 3416804 R hypothetical protein complement(3415953..3416804) Mycobacterium marinum M 6227084 YP_001851113.1 CDS MMAR_2818 NC_010612.1 3416816 3417079 R hypothetical protein complement(3416816..3417079) Mycobacterium marinum M 6227085 YP_001851114.1 CDS MMAR_2819 NC_010612.1 3417126 3417848 D hypothetical protein 3417126..3417848 Mycobacterium marinum M 6227086 YP_001851115.1 CDS MMAR_2820 NC_010612.1 3417855 3418223 R hypothetical protein complement(3417855..3418223) Mycobacterium marinum M 6227087 YP_001851116.1 CDS aceAb NC_010612.1 3418358 3420646 D involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]; isocitrate lyase AceAb 3418358..3420646 Mycobacterium marinum M 6227088 YP_001851117.1 CDS MMAR_2822 NC_010612.1 3420742 3423807 R PPE family protein complement(3420742..3423807) Mycobacterium marinum M 6227089 YP_001851118.1 CDS MMAR_2823 NC_010612.1 3424577 3424987 D PE-PGRS family protein 3424577..3424987 Mycobacterium marinum M 6227090 YP_001851119.1 CDS MMAR_2824 NC_010612.1 3425132 3426295 D monooxygenase 3425132..3426295 Mycobacterium marinum M 6227091 YP_001851120.1 CDS MMAR_2825 NC_010612.1 3426346 3426813 R hypothetical protein complement(3426346..3426813) Mycobacterium marinum M 6227092 YP_001851121.1 CDS MMAR_2826 NC_010612.1 3426951 3427775 D hypothetical protein 3426951..3427775 Mycobacterium marinum M 6227093 YP_001851122.1 CDS MMAR_2827 NC_010612.1 3427940 3429235 D lipoprotein 3427940..3429235 Mycobacterium marinum M 6227094 YP_001851123.1 CDS lipD NC_010612.1 3429357 3430640 D function unknown, lipolytic enzyme probably involved in cellular metabolism; lipase LipD 3429357..3430640 Mycobacterium marinum M 6227095 YP_001851124.1 CDS MMAR_2829 NC_010612.1 3430661 3431482 R hypothetical protein complement(3430661..3431482) Mycobacterium marinum M 6227096 YP_001851125.1 CDS MMAR_2830 NC_010612.1 3431629 3434247 R hypothetical protein complement(3431629..3434247) Mycobacterium marinum M 6227097 YP_001851126.1 CDS MMAR_2831 NC_010612.1 3434946 3435488 R involved in transcriptional mechanism; transcriptional regulator complement(3434946..3435488) Mycobacterium marinum M 6227098 YP_001851127.1 CDS MMAR_2832 NC_010612.1 3435697 3437703 R hypothetical protein complement(3435697..3437703) Mycobacterium marinum M 6227099 YP_001851128.1 CDS MMAR_2833 NC_010612.1 3437706 3438329 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(3437706..3438329) Mycobacterium marinum M 6227100 YP_001851129.1 CDS MMAR_2834 NC_010612.1 3438882 3439304 R hypothetical protein complement(3438882..3439304) Mycobacterium marinum M 6227101 YP_001851130.1 CDS fadD31 NC_010612.1 3439417 3441291 D activates fatty acids by binding to coenzyme A; putative fatty-acid--CoA ligase 3439417..3441291 Mycobacterium marinum M 6227102 YP_001851131.1 CDS MMAR_2836 NC_010612.1 3441295 3443157 R phosphotransferase complement(3441295..3443157) Mycobacterium marinum M 6227103 YP_001851132.1 CDS MMAR_2837 NC_010612.1 3443238 3443843 R hypothetical protein complement(3443238..3443843) Mycobacterium marinum M 6227104 YP_001851133.1 CDS MMAR_2838 NC_010612.1 3443934 3444467 R hypothetical protein complement(3443934..3444467) Mycobacterium marinum M 6227105 YP_001851134.1 CDS MMAR_2839 NC_010612.1 3444526 3445005 R 16 kDa immunogenic extracellular protein): function unknown; immunogenic protein Mpt63 complement(3444526..3445005) Mycobacterium marinum M 6227106 YP_001851135.1 CDS atsD_2 NC_010612.1 3445237 3447564 D thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase AtsD_2 3445237..3447564 Mycobacterium marinum M 6227107 YP_001851136.1 CDS MMAR_2841 NC_010612.1 3447659 3448420 D hypothetical protein 3447659..3448420 Mycobacterium marinum M 6227108 YP_001851137.1 CDS MMAR_2842 NC_010612.1 3448457 3449314 R function unknown - domain identity suggests Na+- dependant transporter; hypothetical protein complement(3448457..3449314) Mycobacterium marinum M 6227109 YP_001851138.1 CDS MMAR_2843 NC_010612.1 3449384 3450382 R hypothetical protein complement(3449384..3450382) Mycobacterium marinum M 6227110 YP_001851139.1 CDS MMAR_2844 NC_010612.1 3450733 3452121 D catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway.; hydroxydechloroatrazine ethylaminohydrolase 3450733..3452121 Mycobacterium marinum M 6227111 YP_001851140.1 CDS ahpC_1 NC_010612.1 3452542 3453237 R alkyl hydroperoxidase; catalyze the reduction of hydrogen peroxide to water and the reduction of alkyl hydroperoxides to the corresponding alcohols; peroxiredoxin complement(3452542..3453237) Mycobacterium marinum M 6227112 YP_001851141.1 CDS MMAR_2846 NC_010612.1 3453451 3454920 D function unknown: involved in carbohydrate transport and metabolism; alpha-L-fucosidase 3453451..3454920 Mycobacterium marinum M 6227113 YP_001851142.1 CDS MMAR_2847 NC_010612.1 3454991 3455404 D hypothetical protein 3454991..3455404 Mycobacterium marinum M 6227114 YP_001851143.1 CDS MMAR_2848 NC_010612.1 3455501 3456274 D hypothetical protein 3455501..3456274 Mycobacterium marinum M 6227115 YP_001851144.1 CDS MMAR_2849 NC_010612.1 3456322 3457089 R function unknown; probably involved in cellular metabolism; short chain dehydrogenase complement(3456322..3457089) Mycobacterium marinum M 6227116 YP_001851145.1 CDS MMAR_2850 NC_010612.1 3457137 3457622 D hypothetical protein 3457137..3457622 Mycobacterium marinum M 6227117 YP_001851146.1 CDS MMAR_2851 NC_010612.1 3457654 3458508 D function unknown but has weak indentity with hydrolase domains; hypothetical protein 3457654..3458508 Mycobacterium marinum M 6227118 YP_001851147.1 CDS MMAR_2852 NC_010612.1 3458539 3459099 R function unknown but contains dihydrofolate reductase domain; hypothetical protein complement(3458539..3459099) Mycobacterium marinum M 6227119 YP_001851148.1 CDS MMAR_2853 NC_010612.1 3459197 3459661 D hypothetical protein 3459197..3459661 Mycobacterium marinum M 6227120 YP_001851149.1 CDS MMAR_2854 NC_010612.1 3459718 3460461 R hypothetical protein complement(3459718..3460461) Mycobacterium marinum M 6227121 YP_001851150.1 CDS MMAR_2855 NC_010612.1 3460480 3461430 R involved in transcriptional mechanism; transcriptional regulatory protein complement(3460480..3461430) Mycobacterium marinum M 6227122 YP_001851151.1 CDS MMAR_2857 NC_010612.1 3461592 3463013 R Short-chain fatty acids transporter complement(3461592..3463013) Mycobacterium marinum M 6227123 YP_001851152.1 CDS MMAR_5580 NC_010612.1 3463010 3463210 R hypothetical protein complement(3463010..3463210) Mycobacterium marinum M 6227124 YP_001851153.1 CDS MMAR_2858 NC_010612.1 3463454 3463849 D hypothetical protein 3463454..3463849 Mycobacterium marinum M 6227125 YP_001851154.1 CDS MMAR_2859 NC_010612.1 3463887 3465056 D function unknown but domain identity with Fe-S oxidoreductases; oxidoreductase 3463887..3465056 Mycobacterium marinum M 6227126 YP_001851155.1 CDS tpx NC_010612.1 3465144 3465641 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 3465144..3465641 Mycobacterium marinum M 6227127 YP_001851156.1 CDS fadE18 NC_010612.1 3465663 3466751 R function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase FadE18 complement(3465663..3466751) Mycobacterium marinum M 6227128 YP_001851157.1 CDS fadE17 NC_010612.1 3466753 3467982 R function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase FadE17 complement(3466753..3467982) Mycobacterium marinum M 6227129 YP_001851158.1 CDS echA13 NC_010612.1 3468000 3468950 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(3468000..3468950) Mycobacterium marinum M 6227130 YP_001851159.1 CDS MMAR_2864 NC_010612.1 3469186 3470322 D function unknown, probably involved in cellular metabolism; oxygenase 3469186..3470322 Mycobacterium marinum M 6227131 YP_001851160.1 CDS MMAR_2865 NC_010612.1 3470350 3472869 D function unknown, may be involved in electron transfer; oxygenase 3470350..3472869 Mycobacterium marinum M 6227132 YP_001851161.1 CDS ephB NC_010612.1 3472881 3473939 D this enzyme acts on epoxides (alkene oxides, oxiranes) and Arene oxides. plays a role in xenobiotic metabolism by degrading potential toxic epoxides. also determines steady-state levels of physiological mediators; epoxide hydrolase EphB 3472881..3473939 Mycobacterium marinum M 6227133 YP_001851162.1 CDS MMAR_2867 NC_010612.1 3473936 3474469 D function unknown, probably involved in cellular metabolism; oxidoreducatse 3473936..3474469 Mycobacterium marinum M 6227134 YP_001851163.1 CDS ribA1 NC_010612.1 3474466 3475563 D involved in riboflavin biosynthesis [catalytic activity : GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy- 4-(5-phosphoribosylamino)pyrimidine + diphosphate]; riboflavin biosynthesis protein RibA1 3474466..3475563 Mycobacterium marinum M 6227135 YP_001851164.1 CDS MMAR_2869 NC_010612.1 3475567 3476337 D function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 3475567..3476337 Mycobacterium marinum M 6227136 YP_001851165.1 CDS MMAR_2870 NC_010612.1 3476356 3477165 R hypothetical protein complement(3476356..3477165) Mycobacterium marinum M 6227137 YP_001851166.1 CDS MMAR_2871 NC_010612.1 3477414 3477764 D hypothetical protein 3477414..3477764 Mycobacterium marinum M 6227138 YP_001851167.1 CDS MMAR_2872 NC_010612.1 3478149 3478463 D maybe required for the translocation of the substrate across the membrane; multidrug-transport integral membrane protein Mmr-like protein 3478149..3478463 Mycobacterium marinum M 6227139 YP_001851168.1 CDS mce3R NC_010612.1 3478785 3479987 R involved in transcriptional mechanism; repression of the Mce3 operon. could also have a regulatory action on the Mce2 operon; TetR family transcriptional regulator complement(3478785..3479987) Mycobacterium marinum M 6227140 YP_001851169.1 CDS MMAR_2874 NC_010612.1 3480470 3480889 D hypothetical protein 3480470..3480889 Mycobacterium marinum M 6227141 YP_001851170.1 CDS MMAR_2875 NC_010612.1 3480886 3482409 D thought to oxidize a wide variety of aliphatic and aromatic aldehydes; aldehyde dehydrogenase 3480886..3482409 Mycobacterium marinum M 6227142 YP_001851171.1 CDS MMAR_2876 NC_010612.1 3482412 3483599 R function unknown but weak domain identity with two- component response regulators; putative regulatory protein complement(3482412..3483599) Mycobacterium marinum M 6227143 YP_001851172.1 CDS cyp278A1 NC_010612.1 3483725 3485008 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 278A1 Cyp278A1 3483725..3485008 Mycobacterium marinum M 6227144 YP_001851173.1 CDS MMAR_2878 NC_010612.1 3485005 3485421 D function unknown, domain identity with ketosteroid isomerase-related proteins; hypothetical protein 3485005..3485421 Mycobacterium marinum M 6227145 YP_001851174.1 CDS MMAR_2879 NC_010612.1 3485418 3485612 D ferredoxin 3485418..3485612 Mycobacterium marinum M 6227146 YP_001851175.1 CDS yrbE3A NC_010612.1 3485922 3486770 D integral membrane protein YrbE3A 3485922..3486770 Mycobacterium marinum M 6227147 YP_001851176.1 CDS yrbE3B NC_010612.1 3486780 3487634 D function unknown, but probably part of Mce3 operon and member of YrbE family; integral membrane protein, YrbE3B 3486780..3487634 Mycobacterium marinum M 6227148 YP_001851177.1 CDS mce3A NC_010612.1 3487639 3489024 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3A 3487639..3489024 Mycobacterium marinum M 6227149 YP_001851178.1 CDS mce3B NC_010612.1 3489100 3490128 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3B 3489100..3490128 Mycobacterium marinum M 6227150 YP_001851179.1 CDS mce3C NC_010612.1 3490125 3491408 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3C 3490125..3491408 Mycobacterium marinum M 6227151 YP_001851180.1 CDS mce3D NC_010612.1 3491405 3492688 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3D 3491405..3492688 Mycobacterium marinum M 6227152 YP_001851181.1 CDS lprM NC_010612.1 3492688 3493857 D function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein LprM 3492688..3493857 Mycobacterium marinum M 6227153 YP_001851182.1 CDS mce3F NC_010612.1 3493858 3495321 D function unknown, but thought involved in host cell invasion; MCE-family protein Mce3F 3493858..3495321 Mycobacterium marinum M 6227154 YP_001851183.1 CDS MMAR_2888 NC_010612.1 3495365 3495928 D Mce associated membrane protein 3495365..3495928 Mycobacterium marinum M 6227155 YP_001851184.1 CDS MMAR_2889 NC_010612.1 3495925 3496497 D Mce associated membrane protein 3495925..3496497 Mycobacterium marinum M 6227156 YP_001851185.1 CDS MMAR_2890 NC_010612.1 3496559 3497224 D hypothetical protein 3496559..3497224 Mycobacterium marinum M 6227157 YP_001851186.1 CDS MMAR_2891 NC_010612.1 3497305 3497673 R hypothetical protein complement(3497305..3497673) Mycobacterium marinum M 6227158 YP_001851187.1 CDS MMAR_2892 NC_010612.1 3497766 3498176 R hypothetical protein complement(3497766..3498176) Mycobacterium marinum M 6227159 YP_001851188.1 CDS MMAR_2893 NC_010612.1 3498254 3498532 R hypothetical protein complement(3498254..3498532) Mycobacterium marinum M 6227160 YP_001851189.1 CDS MMAR_2894 NC_010612.1 3498706 3499398 R PE family protein complement(3498706..3499398) Mycobacterium marinum M 6227161 YP_001851190.1 CDS MMAR_2895 NC_010612.1 3500872 3502071 D PPE family protein 3500872..3502071 Mycobacterium marinum M 6227162 YP_001851191.1 CDS MMAR_2896 NC_010612.1 3502651 3503553 D function unknown - possible role in cell-wall biogenesis; nucleoside-diphosphate-sugar epimerase WcaG-like protein 3502651..3503553 Mycobacterium marinum M 6227163 YP_001851192.1 CDS MMAR_2897 NC_010612.1 3503732 3504550 D function unknown: some similarity to pMUM CDS, hypothetical protein MUP016c; hypothetical protein 3503732..3504550 Mycobacterium marinum M 6227164 YP_001851193.1 CDS MMAR_2898 NC_010612.1 3504547 3505284 D function unknown; some similarity to MUP015c from pMUM001; hypothetical protein 3504547..3505284 Mycobacterium marinum M 6227165 YP_001851194.1 CDS MMAR_2899 NC_010612.1 3505396 3505662 R hypothetical protein complement(3505396..3505662) Mycobacterium marinum M 6227166 YP_001851195.1 CDS MMAR_2900 NC_010612.1 3505822 3506082 R this protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; iron-regulated elongation factor Tu Tuf-like protein complement(3505822..3506082) Mycobacterium marinum M 6227167 YP_001851196.1 CDS MMAR_2901 NC_010612.1 3506156 3506524 D hypothetical protein 3506156..3506524 Mycobacterium marinum M 6227168 YP_001851197.1 CDS MMAR_2902 NC_010612.1 3506556 3507389 R possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls; beta-1,3-glucanase complement(3506556..3507389) Mycobacterium marinum M 6227169 YP_001851198.1 CDS MMAR_2903 NC_010612.1 3507458 3508471 R NADP-dependent oxidoreductase complement(3507458..3508471) Mycobacterium marinum M 6227170 YP_001851199.1 CDS MMAR_2904 NC_010612.1 3508570 3509427 D O-methyltransferase 3508570..3509427 Mycobacterium marinum M 6227171 YP_001851200.1 CDS MMAR_2905 NC_010612.1 3509697 3509957 D hypothetical protein 3509697..3509957 Mycobacterium marinum M 6227172 YP_001851201.1 CDS MMAR_2906 NC_010612.1 3510060 3511106 D function unknown but some domain identity with Zn- dependent proteases; hypothetical protein 3510060..3511106 Mycobacterium marinum M 6227173 YP_001851202.1 CDS MMAR_2907 NC_010612.1 3511116 3512270 R function unknown; contains serine proteinase inhibitors (serpin) domain homology; hypothetical protein complement(3511116..3512270) Mycobacterium marinum M 6227174 YP_001851203.1 CDS MMAR_2908 NC_010612.1 3512283 3512978 R hydrolysis of cutin (a polyester that forms the structure of plant cuticle); cutinase complement(3512283..3512978) Mycobacterium marinum M 6227175 YP_001851204.1 CDS MMAR_2910 NC_010612.1 3513567 3513797 D hypothetical protein 3513567..3513797 Mycobacterium marinum M 6227177 YP_001851205.1 CDS MMAR_2911 NC_010612.1 3513841 3514191 D hypothetical protein 3513841..3514191 Mycobacterium marinum M 6227178 YP_001851206.1 CDS MMAR_2912 NC_010612.1 3514344 3515207 D hydrolase or acyltransferase 3514344..3515207 Mycobacterium marinum M 6227179 YP_001851207.1 CDS betP NC_010612.1 3515567 3517363 D high-affinity uptake of glycine betaine. supposed responsible for the translocation of the substrate across the membrane; glycine betaine transport integral membrane protein BetP 3515567..3517363 Mycobacterium marinum M 6227180 YP_001851208.1 CDS katG NC_010612.1 3517457 3519688 R multifunctional enzyme, exhibiting both a catalase, a broad-spectrum peroxidase, and a peroxynitritase activities. may play a role in the intracellular survival of mycobacteria within macrophages; protection against reactive oxygen and nitrogen intermediates produced by phagocytic cells. seems regulated by SigB [catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O]; catalase-peroxidase-peroxynitritase T KatG complement(3517457..3519688) Mycobacterium marinum M 6227181 YP_001851209.1 CDS furA NC_010612.1 3519725 3520141 R acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene; ferric uptake regulation protein FurA complement(3519725..3520141) Mycobacterium marinum M 6227182 YP_001851210.1 CDS MMAR_2916 NC_010612.1 3520507 3520956 D hypothetical protein 3520507..3520956 Mycobacterium marinum M 6227183 YP_001851211.1 CDS MMAR_2917 NC_010612.1 3521124 3521993 D hypothetical protein 3521124..3521993 Mycobacterium marinum M 6227184 YP_001851212.1 CDS MMAR_2918 NC_010612.1 3522027 3522881 R may be a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]; thiosulfate sulfotransferase complement(3522027..3522881) Mycobacterium marinum M 6227185 YP_001851213.1 CDS MMAR_2919 NC_010612.1 3523014 3523709 R hypothetical protein complement(3523014..3523709) Mycobacterium marinum M 6227186 YP_001851214.1 CDS mmaA2_1 NC_010612.1 3523957 3524820 D adds the distal cyclopropane ring to alpha-meroacid in mycolic acid biosynthesis. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 2 MmaA2 3523957..3524820 Mycobacterium marinum M 6227187 YP_001851215.1 CDS MMAR_2921 NC_010612.1 3525354 3525632 D hypothetical protein 3525354..3525632 Mycobacterium marinum M 6227188 YP_001851216.1 CDS MMAR_2922 NC_010612.1 3525739 3526422 D methylation of unknown substrate; O-methyltransferase 3525739..3526422 Mycobacterium marinum M 6227189 YP_001851217.1 CDS MMAR_2923 NC_010612.1 3526403 3527455 R hypothetical protein complement(3526403..3527455) Mycobacterium marinum M 6227190 YP_001851218.1 CDS MMAR_2924 NC_010612.1 3527466 3528224 R methylation of unknown substrate; SAM-dependent methyltransferase complement(3527466..3528224) Mycobacterium marinum M 6227191 YP_001851219.1 CDS MMAR_2925 NC_010612.1 3528218 3529477 R glycosyltransferase complement(3528218..3529477) Mycobacterium marinum M 6227192 YP_001851220.1 CDS MMAR_2926 NC_010612.1 3529642 3530742 R function unknown; possible role in deamination [amino acid transport and metabolism]; glycine/D-amino acid oxidase complement(3529642..3530742) Mycobacterium marinum M 6227193 YP_001851221.1 CDS MMAR_2927 NC_010612.1 3530907 3531320 R function unknown; contains a putative glyoxalase domain; hypothetical protein complement(3530907..3531320) Mycobacterium marinum M 6227194 YP_001851222.1 CDS MMAR_2928 NC_010612.1 3531548 3532876 D PPE family protein 3531548..3532876 Mycobacterium marinum M 6227195 YP_001851223.1 CDS MMAR_2929 NC_010612.1 3533230 3533553 D hypothetical protein 3533230..3533553 Mycobacterium marinum M 6227196 YP_001851224.1 CDS cyp147G1 NC_010612.1 3533667 3534935 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 147G1 Cyp147G1 complement(3533667..3534935) Mycobacterium marinum M 6227197 YP_001851225.1 CDS MMAR_2931 NC_010612.1 3534978 3536381 R ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably the reductase required for cytochrome P-450 function; ferredoxin reductase complement(3534978..3536381) Mycobacterium marinum M 6227198 YP_001851226.1 CDS MMAR_2932 NC_010612.1 3536378 3536593 R ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably the reductase required for cytochrome P-450 function; ferredoxin reductase FdxD complement(3536378..3536593) Mycobacterium marinum M 6227199 YP_001851227.1 CDS MMAR_2933 NC_010612.1 3536853 3538514 D PE-PGRS family protein 3536853..3538514 Mycobacterium marinum M 6227200 YP_001851228.1 CDS cfp21 NC_010612.1 3538558 3539199 R hydrolysis of cutin; cutinase Cfp21 complement(3538558..3539199) Mycobacterium marinum M 6227201 YP_001851229.1 CDS MMAR_2935 NC_010612.1 3539304 3540569 R hypothetical protein complement(3539304..3540569) Mycobacterium marinum M 6227202 YP_001851230.1 CDS fadD9_1 NC_010612.1 3540903 3544445 D function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD9 3540903..3544445 Mycobacterium marinum M 6227203 YP_001851231.1 CDS MMAR_2937 NC_010612.1 3544485 3545033 R hypothetical protein complement(3544485..3545033) Mycobacterium marinum M 6227204 YP_001851232.1 CDS MMAR_2938 NC_010612.1 3545143 3545772 R function unknown, probably involved in cellular metabolism; nitroreductase complement(3545143..3545772) Mycobacterium marinum M 6227205 YP_001851233.1 CDS MMAR_2939 NC_010612.1 3545896 3546441 D possibly involved in transcriptional mechanism; transcriptional regulatory protein 3545896..3546441 Mycobacterium marinum M 6227206 YP_001851234.1 CDS MMAR_2940 NC_010612.1 3546441 3547604 D hypothetical protein 3546441..3547604 Mycobacterium marinum M 6227207 YP_001851235.1 CDS MMAR_2941 NC_010612.1 3547745 3549709 D involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; membrane-anchored serine/threonine-protein kinase 3547745..3549709 Mycobacterium marinum M 6227208 YP_001851236.1 CDS MMAR_2942 NC_010612.1 3549917 3550579 R function unknown; hypothetical protein complement(3549917..3550579) Mycobacterium marinum M 6227209 YP_001851237.1 CDS MMAR_2943 NC_010612.1 3550668 3551246 D hypothetical protein 3550668..3551246 Mycobacterium marinum M 6227210 YP_001851238.1 CDS MMAR_2944 NC_010612.1 3551272 3552981 R PPE family protein complement(3551272..3552981) Mycobacterium marinum M 6227211 YP_001851239.1 CDS MMAR_2945 NC_010612.1 3553803 3554792 D amino acid transport and metabolism; 1-aminocyclopropane-1-carboxylate deaminase 3553803..3554792 Mycobacterium marinum M 6227212 YP_001851240.1 CDS MMAR_2946 NC_010612.1 3555064 3555534 R hypothetical protein complement(3555064..3555534) Mycobacterium marinum M 6227213 YP_001851241.1 CDS MMAR_2947 NC_010612.1 3555707 3559648 D possibly has helicase activity; HrpA-like helicase 3555707..3559648 Mycobacterium marinum M 6227214 YP_001851242.1 CDS MMAR_2948 NC_010612.1 3559764 3562364 D PE-PGRS family protein 3559764..3562364 Mycobacterium marinum M 6227215 YP_001851243.1 CDS MMAR_2949 NC_010612.1 3562424 3562981 R function unknown. secreted protein; hypothetical protein complement(3562424..3562981) Mycobacterium marinum M 6227216 YP_001851244.1 CDS MMAR_2950 NC_010612.1 3563583 3564554 D thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle; oxidoreductase 3563583..3564554 Mycobacterium marinum M 6227217 YP_001851245.1 CDS MMAR_2951 NC_010612.1 3564747 3565175 D contains a C-term cellobiohydrolase a (1,4- beta-cellobiosidase a) domain and a N-term cellulose- binding domain (CBD) domain. the CBD is found either at the N-term or at the C-term of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases; chitinase/cellulase 3564747..3565175 Mycobacterium marinum M 6227218 YP_001851246.1 CDS MMAR_2952 NC_010612.1 3565421 3566230 D hypothetical protein 3565421..3566230 Mycobacterium marinum M 6227219 YP_001851247.1 CDS MMAR_2953 NC_010612.1 3566323 3567150 R function unknown. possible secreted protein; hypothetical protein complement(3566323..3567150) Mycobacterium marinum M 6227220 YP_001851248.1 CDS MMAR_2954 NC_010612.1 3567479 3569164 R function unknown; probably involved in cellular metabolism, probably electron-transfer-linked; dehydrogenase fad flavoprotein GMC oxidoreductase complement(3567479..3569164) Mycobacterium marinum M 6227221 YP_001851249.1 CDS MMAR_2955 NC_010612.1 3569463 3569714 D hypothetical protein 3569463..3569714 Mycobacterium marinum M 6227222 YP_001851250.1 CDS MMAR_2956 NC_010612.1 3569704 3570015 D function unknown but in E. coli PemK is a growth inhibitor known to bind to the promoter region of the PEM operon, auto-regulating synthesis; PemK-like protein 3569704..3570015 Mycobacterium marinum M 6227223 YP_001851251.1 CDS mimD NC_010612.1 3571158 3573353 D macrophage infection protein, MimD 3571158..3573353 Mycobacterium marinum M 6227225 YP_001851252.1 CDS MMAR_2959 NC_010612.1 3573899 3574927 R function unknown; probably involved in cellular metabolism; Zn-dependent alcohol dehydrogenase complement(3573899..3574927) Mycobacterium marinum M 6227226 YP_001851253.1 CDS MMAR_2960 NC_010612.1 3575004 3575603 D function unknown, belongs AcrR family of transcriptional regulators; transcriptional regulatory protein 3575004..3575603 Mycobacterium marinum M 6227227 YP_001851254.1 CDS MMAR_2961 NC_010612.1 3575624 3575956 D hypothetical protein 3575624..3575956 Mycobacterium marinum M 6227228 YP_001851255.1 CDS MMAR_2962 NC_010612.1 3576003 3579239 R involved in transcriptional mechanism; transcriptional regulatory protein complement(3576003..3579239) Mycobacterium marinum M 6227229 YP_001851256.1 CDS MMAR_2963 NC_010612.1 3579465 3581297 D function unknown role in cellular metabolism. contains predicted signal peptide sequence; oxidoreductase 3579465..3581297 Mycobacterium marinum M 6227230 YP_001851257.1 CDS MMAR_2964 NC_010612.1 3581248 3584406 D function unknown, but probably involved in sugar or lipid transport. contains a C-term patatin-like phospholipase domain. the patatin family consists of various patatin glycoproteins from plants. the patatin protein accounts for up to 40% of the total soluble protein in potato tubers. patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. this predicted protein also contains multiple membrane-spanning domains and a beta-barrel structure, characteristic of pore-forming membrane proteins; transmembrane transport protein 3581248..3584406 Mycobacterium marinum M 6227231 YP_001851258.1 CDS nadR NC_010612.1 3584821 3585843 D involved in NAD metabolism [coenzyme metabolism]; ATPase/kinase, NadR 3584821..3585843 Mycobacterium marinum M 6227232 YP_001851259.1 CDS MMAR_2966 NC_010612.1 3585953 3587632 D translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane drug efflux protein 3585953..3587632 Mycobacterium marinum M 6227233 YP_001851260.1 CDS MMAR_2967 NC_010612.1 3587686 3588222 D hypothetical protein 3587686..3588222 Mycobacterium marinum M 6227234 YP_001851261.1 CDS MMAR_2968 NC_010612.1 3588249 3588974 D hypothetical protein 3588249..3588974 Mycobacterium marinum M 6227235 YP_001851262.1 CDS MMAR_2969 NC_010612.1 3589577 3591604 D PE-PGRS family protein 3589577..3591604 Mycobacterium marinum M 6227236 YP_001851263.1 CDS MMAR_2970 NC_010612.1 3591944 3593773 R PE-PGRS family protein complement(3591944..3593773) Mycobacterium marinum M 6227237 YP_001851264.1 CDS MMAR_2971 NC_010612.1 3594195 3595016 R methylation of unknown substrate; O-methyltransferase complement(3594195..3595016) Mycobacterium marinum M 6227238 YP_001851265.1 CDS MMAR_2972 NC_010612.1 3595313 3596377 D function unknown but contains a sugar isomerase N- term domain and N and C-term predicted beta-barrels; putative sugar transport protein 3595313..3596377 Mycobacterium marinum M 6227239 YP_001851266.1 CDS MMAR_2973 NC_010612.1 3596523 3597854 D function unknown; PE-PGRS family protein 3596523..3597854 Mycobacterium marinum M 6227240 YP_001851267.1 CDS MMAR_2974 NC_010612.1 3597910 3598743 R could possibly oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3- hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase complement(3597910..3598743) Mycobacterium marinum M 6227241 YP_001851268.1 CDS MMAR_2975 NC_010612.1 3598740 3600152 R function unknown; hypothetical protein complement(3598740..3600152) Mycobacterium marinum M 6227242 YP_001851269.1 CDS MMAR_2976 NC_010612.1 3600432 3601874 D function unknown; contains a putative flavoprotein domain; hypothetical protein 3600432..3601874 Mycobacterium marinum M 6227243 YP_001851270.1 CDS fatA NC_010612.1 3601884 3602636 D function unknown; possible role in cleavage of unknown acyl-ACP substrate; acyl-ACP thioesterase, FatA 3601884..3602636 Mycobacterium marinum M 6227244 YP_001851271.1 CDS cyp135B6 NC_010612.1 3603061 3604482 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 135B6 Cyp135B6 3603061..3604482 Mycobacterium marinum M 6227245 YP_001851272.1 CDS MMAR_2979 NC_010612.1 3604789 3605397 D involved in transcriptional mechanism; TetR family transcriptional regulator 3604789..3605397 Mycobacterium marinum M 6227246 YP_001851273.1 CDS MMAR_2980 NC_010612.1 3605418 3606500 D function unknown; contains flavin-utilizing monoxygenase domain; hypothetical protein 3605418..3606500 Mycobacterium marinum M 6227247 YP_001851274.1 CDS fabG3_1 NC_010612.1 3606541 3607323 D function unknown; thought to be involved in lipid biosynthesis [catalytic activity: androstan-3-alpha,17- beta-diol + NAD+ = 17-beta-hydroxyandrostan-3-one + NADH]; 20-beta-hydroxysteroid dehydrogenase 3606541..3607323 Mycobacterium marinum M 6227248 YP_001851275.1 CDS MMAR_2982 NC_010612.1 3607311 3608681 D hypothetical protein 3607311..3608681 Mycobacterium marinum M 6227249 YP_001851276.1 CDS MMAR_2983 NC_010612.1 3608847 3609758 D function unknown; contains two universal stress protein family domains. the universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general 'stress endurance' activity; hypothetical protein 3608847..3609758 Mycobacterium marinum M 6227250 YP_001851277.1 CDS MMAR_2984 NC_010612.1 3610187 3610858 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(3610187..3610858) Mycobacterium marinum M 6227251 YP_001851278.1 CDS bphC_1 NC_010612.1 3610941 3612113 D involved in the degradation of biphenyl [catalytic activity: biphenyl-2,3-diol + O(2) = 2-hydroxy-6-OXO-6- phenylhexa-2,4-dienoate + H(2)O]; 2,3-dihydroxybiphenyl-1,2-dioxygenase BphC 3610941..3612113 Mycobacterium marinum M 6227252 YP_001851279.1 CDS MMAR_2986 NC_010612.1 3612110 3613048 D isomerizes HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) to ohed (2-OXO-hept-3-ene-1,7-dioate); 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 3612110..3613048 Mycobacterium marinum M 6227253 YP_001851280.1 CDS mhpA NC_010612.1 3613045 3614589 D catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 3613045..3614589 Mycobacterium marinum M 6227254 YP_001851281.1 CDS MMAR_2988 NC_010612.1 3614654 3615127 D acetyltransferase 3614654..3615127 Mycobacterium marinum M 6227255 YP_001851282.1 CDS MMAR_2989 NC_010612.1 3615342 3615575 D hypothetical protein 3615342..3615575 Mycobacterium marinum M 6227256 YP_001851283.1 CDS hspR_2 NC_010612.1 3615717 3616115 R involved in transcriptional regulation (repression) of heat shock proteins E.G. DnaK, GrpE, DnaJ. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock; heat shock protein transcriptional repressor HspR_2 complement(3615717..3616115) Mycobacterium marinum M 6227257 YP_001851284.1 CDS MMAR_2991 NC_010612.1 3616260 3616709 D function unknown. may be involved in a chaperoning process; molecular chaperone 3616260..3616709 Mycobacterium marinum M 6227258 YP_001851285.1 CDS folE_1 NC_010612.1 3617137 3617865 D involved in the biosynthesis of tetrahydrofolate (at the first step) [catalytic activity: GTP + 2 H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)DiHYD ro pteridine triphosphate]; GTP cyclohydrolase I FolE 3617137..3617865 Mycobacterium marinum M 6227259 YP_001851286.1 CDS MMAR_2993 NC_010612.1 3617900 3618787 R hypothetical protein complement(3617900..3618787) Mycobacterium marinum M 6227260 YP_001851287.1 CDS fdxA_2 NC_010612.1 3618804 3619148 R involved in electron transfer; ferredoxin FdxA_2 complement(3618804..3619148) Mycobacterium marinum M 6227261 YP_001851288.1 CDS MMAR_2995 NC_010612.1 3619238 3620122 R function unknown. possibly involved in signal transduction mechanisms; hypothetical protein complement(3619238..3620122) Mycobacterium marinum M 6227262 YP_001851289.1 CDS MMAR_2996 NC_010612.1 3620291 3620557 R hypothetical protein complement(3620291..3620557) Mycobacterium marinum M 6227263 YP_001851290.1 CDS MMAR_2997 NC_010612.1 3620554 3621168 R the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; alternative RNA polymerase sigma factor complement(3620554..3621168) Mycobacterium marinum M 6227264 YP_001851291.1 CDS MMAR_2998 NC_010612.1 3621188 3622255 R function unknown. possibly involved in lipid metabolism; hypothetical protein complement(3621188..3622255) Mycobacterium marinum M 6227265 YP_001851292.1 CDS MMAR_2999 NC_010612.1 3622427 3622951 R hypothetical protein complement(3622427..3622951) Mycobacterium marinum M 6227266 YP_001851293.1 CDS MMAR_5570 NC_010612.1 3623110 3623301 D hypothetical protein 3623110..3623301 Mycobacterium marinum M 6227267 YP_001851294.1 CDS esxR NC_010612.1 3623357 3623647 R EsaT-6 family protein complement(3623357..3623647) Mycobacterium marinum M 6227268 YP_001851295.1 CDS esxG_1 NC_010612.1 3623683 3623976 R EsaT-6 like protein EsxG complement(3623683..3623976) Mycobacterium marinum M 6227269 YP_001851296.1 CDS MMAR_3002 NC_010612.1 3624013 3625299 R PPE family protein complement(3624013..3625299) Mycobacterium marinum M 6227270 YP_001851297.1 CDS MMAR_3003 NC_010612.1 3625310 3625615 R PE family protein complement(3625310..3625615) Mycobacterium marinum M 6227271 YP_001851298.1 CDS MMAR_3005 NC_010612.1 3626054 3627250 R PPE family protein complement(3626054..3627250) Mycobacterium marinum M 6227272 YP_001851299.1 CDS MMAR_3006 NC_010612.1 3627728 3628918 R PPE family protein complement(3627728..3628918) Mycobacterium marinum M 6227273 YP_001851300.1 CDS MMAR_3007 NC_010612.1 3629592 3630425 R hypothetical protein complement(3629592..3630425) Mycobacterium marinum M 6227274 YP_001851301.1 CDS MMAR_3008 NC_010612.1 3630635 3632554 R PE-PGRS family protein complement(3630635..3632554) Mycobacterium marinum M 6227275 YP_001851302.1 CDS MMAR_3010 NC_010612.1 3632717 3633682 R hypothetical protein complement(3632717..3633682) Mycobacterium marinum M 6227276 YP_001851303.1 CDS MMAR_3011 NC_010612.1 3633785 3634855 R thought to be involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system; sugar-transport ATP-binding protein ABC transporter complement(3633785..3634855) Mycobacterium marinum M 6227277 YP_001851304.1 CDS MMAR_3012 NC_010612.1 3634861 3635703 R sugar ABC transporter complement(3634861..3635703) Mycobacterium marinum M 6227278 YP_001851305.1 CDS MMAR_3013 NC_010612.1 3635690 3636643 R thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar ABC transporter integral membrane protein complement(3635690..3636643) Mycobacterium marinum M 6227279 YP_001851306.1 CDS MMAR_3014 NC_010612.1 3636640 3637956 R sugar-binding lipoprotein complement(3636640..3637956) Mycobacterium marinum M 6227280 YP_001851307.1 CDS MMAR_3015 NC_010612.1 3638038 3638835 R hypothetical protein complement(3638038..3638835) Mycobacterium marinum M 6227281 YP_001851308.1 CDS pncA NC_010612.1 3638835 3639395 R converts amides such as nicotinamide to corresponding acid; pyrazinamidase/nicotinamidase, PncA complement(3638835..3639395) Mycobacterium marinum M 6227282 YP_001851309.1 CDS MMAR_3017 NC_010612.1 3639491 3640306 D hypothetical protein 3639491..3640306 Mycobacterium marinum M 6227283 YP_001851310.1 CDS MMAR_3018 NC_010612.1 3640303 3640818 R function unknown, in general gluconate kinase catalyzes the phosphoryl transfer from ATP to gluconate. the resulting product gluconate-6-phosphate is an important precursor of gluconate metabolism; gluconate kinase complement(3640303..3640818) Mycobacterium marinum M 6227284 YP_001851311.1 CDS MMAR_3019 NC_010612.1 3640815 3642815 R hypothetical protein complement(3640815..3642815) Mycobacterium marinum M 6227285 YP_001851312.1 CDS lipT NC_010612.1 3642821 3644326 R converts unknown esters to corresponding free acid and alcohol; carboxylesterase, LipT complement(3642821..3644326) Mycobacterium marinum M 6227286 YP_001851313.1 CDS lppI NC_010612.1 3644405 3645085 D lipoprotein LppI 3644405..3645085 Mycobacterium marinum M 6227287 YP_001851314.1 CDS MMAR_3022 NC_010612.1 3645417 3645734 D hypothetical protein 3645417..3645734 Mycobacterium marinum M 6227288 YP_001851315.1 CDS MMAR_3023 NC_010612.1 3645738 3646601 D hypothetical protein 3645738..3646601 Mycobacterium marinum M 6227289 YP_001851316.1 CDS MMAR_3024 NC_010612.1 3646743 3649403 R hypothetical protein complement(3646743..3649403) Mycobacterium marinum M 6227290 YP_001851317.1 CDS pks12 NC_010612.1 3649476 3662039 R required for mycoketide synthesis; polyketide synthase complement(3649476..3662039) Mycobacterium marinum M 6227291 YP_001851318.1 CDS MMAR_3026 NC_010612.1 3662370 3662600 R hypothetical protein complement(3662370..3662600) Mycobacterium marinum M 6227292 YP_001851319.1 CDS MMAR_3027 NC_010612.1 3662916 3663221 D hypothetical protein 3662916..3663221 Mycobacterium marinum M 6227293 YP_001851320.1 CDS ppm1B NC_010612.1 3663242 3664048 R transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis; polyprenol-monophosphomannose synthase, Ppm1B complement(3663242..3664048) Mycobacterium marinum M 6227294 YP_001851321.1 CDS ppm1A NC_010612.1 3664074 3666188 R transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis; polyprenol-monophosphomannose synthase, Ppm1A complement(3664074..3666188) Mycobacterium marinum M 6227295 YP_001851322.1 CDS MMAR_3030 NC_010612.1 3666181 3667785 R domain identity with predicted metal-dependent hydrolases with the TIM-barrel folds; hypothetical protein complement(3666181..3667785) Mycobacterium marinum M 6227296 YP_001851323.1 CDS fxsA NC_010612.1 3667816 3668448 R F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein complement(3667816..3668448) Mycobacterium marinum M 6227297 YP_001851324.1 CDS MMAR_3032 NC_010612.1 3668449 3669231 D domain identity with dienelactone hydrolases; hypothetical protein 3668449..3669231 Mycobacterium marinum M 6227298 YP_001851325.1 CDS MMAR_3033 NC_010612.1 3669449 3671083 D hypothetical protein 3669449..3671083 Mycobacterium marinum M 6227299 YP_001851326.1 CDS MMAR_3034 NC_010612.1 3671108 3672799 R transmembrane protein complement(3671108..3672799) Mycobacterium marinum M 6227300 YP_001851327.1 CDS MMAR_3035 NC_010612.1 3672840 3673718 R function unknown. domain identity to ThiJ-like intracellular proteases/amidases; hypothetical protein complement(3672840..3673718) Mycobacterium marinum M 6227301 YP_001851328.1 CDS MMAR_3036 NC_010612.1 3673729 3674118 R hypothetical protein complement(3673729..3674118) Mycobacterium marinum M 6227302 YP_001851329.1 CDS cobN NC_010612.1 3674223 3677795 R with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN complement(3674223..3677795) Mycobacterium marinum M 6227303 YP_001851330.1 CDS MMAR_3038 NC_010612.1 3677788 3678009 R hypothetical protein complement(3677788..3678009) Mycobacterium marinum M 6227304 YP_001851331.1 CDS MMAR_3039 NC_010612.1 3678056 3679597 R membrane-bound oxidoreductase complement(3678056..3679597) Mycobacterium marinum M 6227305 YP_001851332.1 CDS MMAR_3040 NC_010612.1 3679760 3680587 D cellular metabolism; short chain dehydrogenase 3679760..3680587 Mycobacterium marinum M 6227306 YP_001851333.1 CDS MMAR_3041 NC_010612.1 3680584 3681480 D hypothetical protein 3680584..3681480 Mycobacterium marinum M 6227307 YP_001851334.1 CDS MMAR_3042 NC_010612.1 3681566 3682312 R function unknown. contains adenylate cyclase domain; hypothetical protein complement(3681566..3682312) Mycobacterium marinum M 6227308 YP_001851335.1 CDS MMAR_3043 NC_010612.1 3682421 3685648 D adenylate cyclase 3682421..3685648 Mycobacterium marinum M 6227309 YP_001851336.1 CDS MMAR_3044 NC_010612.1 3685734 3686843 D cobalamin biosynthesis protein 3685734..3686843 Mycobacterium marinum M 6227310 YP_001851337.1 CDS cobH NC_010612.1 3686861 3687487 D catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 3686861..3687487 Mycobacterium marinum M 6227311 YP_001851338.1 CDS cobI NC_010612.1 3687484 3688953 D involved in cobalamin biosynthesis; bifunctional cobalamin adenosyltransferase CobI/precorrin-3B C(17)-methyltransferase CobJ 3687484..3688953 Mycobacterium marinum M 6227312 YP_001851339.1 CDS MMAR_3047 NC_010612.1 3688950 3690176 R hypothetical protein complement(3688950..3690176) Mycobacterium marinum M 6227313 YP_001851340.1 CDS mmpL5_5 NC_010612.1 3690209 3693205 R thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(3690209..3693205) Mycobacterium marinum M 6227314 YP_001851341.1 CDS mmpS4_1 NC_010612.1 3693202 3693633 R membrane transporter complement(3693202..3693633) Mycobacterium marinum M 6227315 YP_001851342.1 CDS blaC NC_010612.1 3693985 3694920 R hydrolyses beta-lactams to generate corresponding beta-amino acid [catalytic activity: a beta-lactam + H(2)O = a substituted beta-amino acid]; class a beta-lactamase, BlaC complement(3693985..3694920) Mycobacterium marinum M 6227316 YP_001851343.1 CDS sigC NC_010612.1 3695056 3695610 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 3695056..3695610 Mycobacterium marinum M 6227317 YP_001851344.1 CDS cobK NC_010612.1 3695616 3696344 R CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase complement(3695616..3696344) Mycobacterium marinum M 6227318 YP_001851345.1 CDS cobM NC_010612.1 3696341 3697090 R involved in cobalamin biosynthesis; precorrin-4 C11-methyltransferase, CobM complement(3696341..3697090) Mycobacterium marinum M 6227319 YP_001851346.1 CDS cobL NC_010612.1 3697087 3698259 R precorrin-6y methyltransferase, CobL complement(3697087..3698259) Mycobacterium marinum M 6227320 YP_001851347.1 CDS MMAR_3055 NC_010612.1 3698256 3699005 R short chain dehydrogenase complement(3698256..3699005) Mycobacterium marinum M 6227321 YP_001851348.1 CDS MMAR_3056 NC_010612.1 3699041 3699451 D hypothetical protein 3699041..3699451 Mycobacterium marinum M 6227322 YP_001851349.1 CDS MMAR_3058 NC_010612.1 3699989 3701458 R hypothetical protein complement(3699989..3701458) Mycobacterium marinum M 6227324 YP_001851350.1 CDS MMAR_3059 NC_010612.1 3701809 3702639 R hypothetical protein complement(3701809..3702639) Mycobacterium marinum M 6227325 YP_001851351.1 CDS MMAR_3060 NC_010612.1 3702636 3703472 R hypothetical protein complement(3702636..3703472) Mycobacterium marinum M 6227326 YP_001851352.1 CDS MMAR_3061 NC_010612.1 3703472 3705814 R hypothetical protein complement(3703472..3705814) Mycobacterium marinum M 6227327 YP_001851353.1 CDS MMAR_3063 NC_010612.1 3706957 3707499 D hypothetical protein 3706957..3707499 Mycobacterium marinum M 6227329 YP_001851354.1 CDS MMAR_3064 NC_010612.1 3707486 3708001 D hypothetical protein 3707486..3708001 Mycobacterium marinum M 6227330 YP_001851355.1 CDS MMAR_3065 NC_010612.1 3708649 3709188 D hypothetical protein 3708649..3709188 Mycobacterium marinum M 6227331 YP_001851356.1 CDS MMAR_3066 NC_010612.1 3709178 3711334 D hypothetical protein 3709178..3711334 Mycobacterium marinum M 6227332 YP_001851357.1 CDS MMAR_3067 NC_010612.1 3711331 3712299 D hypothetical protein 3711331..3712299 Mycobacterium marinum M 6227333 YP_001851358.1 CDS MMAR_3068 NC_010612.1 3712396 3715758 R hypothetical protein complement(3712396..3715758) Mycobacterium marinum M 6227334 YP_001851359.1 CDS MMAR_3069 NC_010612.1 3715751 3716446 R hypothetical protein complement(3715751..3716446) Mycobacterium marinum M 6227335 YP_001851360.1 CDS MMAR_3070 NC_010612.1 3716443 3717888 R hypothetical protein complement(3716443..3717888) Mycobacterium marinum M 6227336 YP_001851361.1 CDS MMAR_3071 NC_010612.1 3718588 3718851 R hypothetical protein complement(3718588..3718851) Mycobacterium marinum M 6227337 YP_001851362.1 CDS MMAR_3072 NC_010612.1 3718858 3721434 R hypothetical protein complement(3718858..3721434) Mycobacterium marinum M 6227338 YP_001851363.1 CDS MMAR_3073 NC_010612.1 3721551 3722114 D hypothetical protein 3721551..3722114 Mycobacterium marinum M 6227339 YP_001851364.1 CDS MMAR_3074 NC_010612.1 3722140 3724383 R hypothetical protein complement(3722140..3724383) Mycobacterium marinum M 6227340 YP_001851365.1 CDS pepE NC_010612.1 3724420 3725547 R hydrolysis of peptide bonds; dipeptidase PepE complement(3724420..3725547) Mycobacterium marinum M 6227341 YP_001851366.1 CDS MMAR_3076 NC_010612.1 3725671 3726627 D involved in DNA metabolism; 5'-3' exonuclease 3725671..3726627 Mycobacterium marinum M 6227342 YP_001851367.1 CDS MMAR_3077 NC_010612.1 3726640 3727404 R hypothetical protein complement(3726640..3727404) Mycobacterium marinum M 6227343 YP_001851368.1 CDS helY NC_010612.1 3727511 3730267 R DNA helicase activity; ATP-dependent DNA helicase HelY complement(3727511..3730267) Mycobacterium marinum M 6227344 YP_001851369.1 CDS tatC NC_010612.1 3730355 3731308 R involved in proteins export: required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K. this sec-independent pathway is termed tat for twin- arginine translocation system; sec-independent protein translocase transmembrane protein TatC complement(3730355..3731308) Mycobacterium marinum M 6227345 YP_001851370.1 CDS tatA NC_010612.1 3731351 3731617 R TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A complement(3731351..3731617) Mycobacterium marinum M 6227346 YP_001851371.1 CDS MMAR_3081 NC_010612.1 3731744 3732712 R hypothetical protein complement(3731744..3732712) Mycobacterium marinum M 6227347 YP_001851372.1 CDS MMAR_3082 NC_010612.1 3732762 3733760 R contains domain homology to transcriptional regulators; hypothetical protein complement(3732762..3733760) Mycobacterium marinum M 6227348 YP_001851373.1 CDS MMAR_3083 NC_010612.1 3733814 3735172 R hypothetical protein complement(3733814..3735172) Mycobacterium marinum M 6227349 YP_001851374.1 CDS prcA NC_010612.1 3735230 3736033 R protein degradation; proteasome PrcA complement(3735230..3736033) Mycobacterium marinum M 6227350 YP_001851375.1 CDS prcB NC_010612.1 3736030 3736899 R protein degradation; proteasome PrcB complement(3736030..3736899) Mycobacterium marinum M 6227351 YP_001851376.1 CDS MMAR_3086 NC_010612.1 3736896 3737090 R hypothetical protein complement(3736896..3737090) Mycobacterium marinum M 6227352 YP_001851377.1 CDS MMAR_3087 NC_010612.1 3737262 3738770 R hypothetical protein complement(3737262..3738770) Mycobacterium marinum M 6227353 YP_001851378.1 CDS MMAR_3088 NC_010612.1 3739067 3740341 D hypothetical protein 3739067..3740341 Mycobacterium marinum M 6227354 YP_001851379.1 CDS MMAR_3089 NC_010612.1 3740382 3741566 D integral membrane protein 3740382..3741566 Mycobacterium marinum M 6227355 YP_001851380.1 CDS MMAR_3090 NC_010612.1 3741538 3742200 D hypothetical protein 3741538..3742200 Mycobacterium marinum M 6227356 YP_001851381.1 CDS MMAR_3091 NC_010612.1 3742222 3744051 R ATPase complement(3742222..3744051) Mycobacterium marinum M 6227357 YP_001851382.1 CDS lppK NC_010612.1 3744367 3745008 D lipoprotein LppK 3744367..3745008 Mycobacterium marinum M 6227358 YP_001851383.1 CDS MMAR_3093 NC_010612.1 3745017 3745319 D hypothetical protein 3745017..3745319 Mycobacterium marinum M 6227359 YP_001851384.1 CDS MMAR_3094 NC_010612.1 3745332 3746174 R involved in transfer of methyl group (from S- adenosyl-L-methionine to a substrate); RNA methyltransferase complement(3745332..3746174) Mycobacterium marinum M 6227360 YP_001851385.1 CDS MMAR_3095 NC_010612.1 3746248 3747129 D has significant domain identity to RecB family exonucleases; hypothetical protein 3746248..3747129 Mycobacterium marinum M 6227361 YP_001851386.1 CDS MMAR_3096 NC_010612.1 3747126 3747905 D hypothetical protein 3747126..3747905 Mycobacterium marinum M 6227362 YP_001851387.1 CDS MMAR_3097 NC_010612.1 3747926 3764707 R Nrp of 5 modules. domain structure (C, a, T) X 5, ending in a te domain. metabolite produced unknown; non-ribosomal peptide synthetase complement(3747926..3764707) Mycobacterium marinum M 6227363 YP_001851388.1 CDS MMAR_3098 NC_010612.1 3764826 3772826 R a single module PKS, with the following domain structure when linked with U/S and D/S ORFs: (KS, ATProp, DH, ER, KR, ACP); polyketide synthase complement(3764826..3772826) Mycobacterium marinum M 6227364 YP_001851389.1 CDS MMAR_3099 NC_010612.1 3772823 3781318 R production of unknown metabolite. this CDS encodes a single NRP and PKS module with domain structure: (KS, Ata, DH, ER, KR, ACP); polyketide synthase and peptide synthetase complement(3772823..3781318) Mycobacterium marinum M 6227365 YP_001851390.1 CDS ermB_1 NC_010612.1 3781744 3783345 D translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane drug efflux protein, ErmB 3781744..3783345 Mycobacterium marinum M 6227366 YP_001851391.1 CDS lpd_1 NC_010612.1 3783385 3784764 R Enables the enzymatic reduction of mercuric ions to elemental mercury; mercuric reductase complement(3783385..3784764) Mycobacterium marinum M 6227367 YP_001851392.1 CDS MMAR_3102 NC_010612.1 3784761 3785243 R hypothetical protein complement(3784761..3785243) Mycobacterium marinum M 6227368 YP_001851393.1 CDS hisG NC_010612.1 3785360 3786220 R long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase complement(3785360..3786220) Mycobacterium marinum M 6227369 YP_001851394.1 CDS hisE NC_010612.1 3786217 3786498 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase complement(3786217..3786498) Mycobacterium marinum M 6227370 YP_001851395.1 CDS MMAR_3105 NC_010612.1 3786617 3788968 R PE-PGRS family protein complement(3786617..3788968) Mycobacterium marinum M 6227371 YP_001851396.1 CDS MMAR_3106 NC_010612.1 3789361 3790800 D PPE family protein 3789361..3790800 Mycobacterium marinum M 6227372 YP_001851397.1 CDS MMAR_3107 NC_010612.1 3791355 3792233 D hypothetical protein 3791355..3792233 Mycobacterium marinum M 6227373 YP_001851398.1 CDS MMAR_3108 NC_010612.1 3792283 3793488 R function unknown, probably involved in cellular metabolism; FAD-dependent oxidoreductase complement(3792283..3793488) Mycobacterium marinum M 6227374 YP_001851399.1 CDS MMAR_3109 NC_010612.1 3793528 3794409 R short chain dehydrogenase complement(3793528..3794409) Mycobacterium marinum M 6227375 YP_001851400.1 CDS mshC NC_010612.1 3794433 3795668 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(3794433..3795668) Mycobacterium marinum M 6227376 YP_001851401.1 CDS gabD1_1 NC_010612.1 3795871 3797487 D involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H]; succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 3795871..3797487 Mycobacterium marinum M 6227377 YP_001851402.1 CDS cysQ NC_010612.1 3797516 3798307 R may help control the pool of 3'-PHOSPHOADENOSIDE 5'- phosphosulfate, or its use in sulfite synthesis (by similarity); monophosphatase CysQ complement(3797516..3798307) Mycobacterium marinum M 6227378 YP_001851403.1 CDS MMAR_3113 NC_010612.1 3798419 3799234 R hypothetical protein complement(3798419..3799234) Mycobacterium marinum M 6227379 YP_001851404.1 CDS MMAR_3114 NC_010612.1 3799218 3799805 R hypothetical protein complement(3799218..3799805) Mycobacterium marinum M 6227380 YP_001851405.1 CDS MMAR_3115 NC_010612.1 3799894 3800640 R hypothetical protein complement(3799894..3800640) Mycobacterium marinum M 6227381 YP_001851406.1 CDS MMAR_3116 NC_010612.1 3800637 3801485 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(3800637..3801485) Mycobacterium marinum M 6227382 YP_001851407.1 CDS MMAR_3117 NC_010612.1 3801529 3801831 R hypothetical protein complement(3801529..3801831) Mycobacterium marinum M 6227383 YP_001851408.1 CDS lppL NC_010612.1 3801942 3803012 D lipoprotein LppL 3801942..3803012 Mycobacterium marinum M 6227384 YP_001851409.1 CDS MMAR_3119 NC_010612.1 3803009 3803272 D hypothetical protein 3803009..3803272 Mycobacterium marinum M 6227385 YP_001851410.1 CDS pyrD NC_010612.1 3803305 3804387 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 3803305..3804387 Mycobacterium marinum M 6227386 YP_001851411.1 CDS MMAR_3121 NC_010612.1 3804399 3805787 R hypothetical protein complement(3804399..3805787) Mycobacterium marinum M 6227387 YP_001851412.1 CDS MMAR_3122 NC_010612.1 3805913 3806440 R function unknown but contains bacterial/archael phosphatidylethanolamine-binding (PEBP) domain; hypothetical protein complement(3805913..3806440) Mycobacterium marinum M 6227388 YP_001851413.1 CDS MMAR_3123 NC_010612.1 3806467 3807822 R function unknown - but has domain identity with cetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases [amino acid transport and metabolism]; hypothetical protein complement(3806467..3807822) Mycobacterium marinum M 6227389 YP_001851414.1 CDS MMAR_3124 NC_010612.1 3808039 3809685 R site-specific integration of bacteriophage DNA; integrase complement(3808039..3809685) Mycobacterium marinum M 6227391 YP_001851415.1 CDS MMAR_3125 NC_010612.1 3809872 3811377 R function unknown, signficant identity with putative plasmid replication initiator protein [streptomyces coelicolor A3(2)]; hypothetical protein complement(3809872..3811377) Mycobacterium marinum M 6227392 YP_001851416.1 CDS MMAR_3126 NC_010612.1 3811374 3812807 R possible role in phage DNA replication. the FtsK/SpoIIIE family contains a putative ATP binding P-loop motif. it is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE, which has roles in regulation of prespore specific gene expression in B. subtilis. a mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. the SpoIIIE protein is implicated in intercellular chromosomal DNA transfer; FtsK/SpoIIIE family protein complement(3811374..3812807) Mycobacterium marinum M 6227393 YP_001851417.1 CDS MMAR_3127 NC_010612.1 3812897 3813241 R putative regulatory protein complement(3812897..3813241) Mycobacterium marinum M 6227394 YP_001851418.1 CDS MMAR_3128 NC_010612.1 3813481 3814299 D hypothetical protein 3813481..3814299 Mycobacterium marinum M 6227395 YP_001851419.1 CDS MMAR_3129 NC_010612.1 3814305 3814772 D may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair; hypothetical protein 3814305..3814772 Mycobacterium marinum M 6227396 YP_001851420.1 CDS MMAR_3130 NC_010612.1 3814783 3815319 R hydrolase complement(3814783..3815319) Mycobacterium marinum M 6227397 YP_001851421.1 CDS MMAR_3132 NC_010612.1 3816292 3817437 R function unknown, reaction: catalysis of the alpha,beta dehydrogenation of the corresponding trans- enoyl-CoA; acyl-CoA dehydrogenase complement(3816292..3817437) Mycobacterium marinum M 6227399 YP_001851422.1 CDS fadD14_1 NC_010612.1 3817480 3819093 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(3817480..3819093) Mycobacterium marinum M 6227400 YP_001851423.1 CDS MMAR_3134 NC_010612.1 3819120 3819773 R function unknown, contains a transglutaminase/protease-like domain; transglutaminases are enzymes that establish covalent links between proteins; hypothetical protein complement(3819120..3819773) Mycobacterium marinum M 6227401 YP_001851424.1 CDS cyp136B2 NC_010612.1 3819770 3821227 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 136B2 Cyp136B2 complement(3819770..3821227) Mycobacterium marinum M 6227402 YP_001851425.1 CDS MMAR_3136 NC_010612.1 3821343 3822878 R function unknown; probably involved in cellular metabolism; monooxygenase complement(3821343..3822878) Mycobacterium marinum M 6227403 YP_001851426.1 CDS MMAR_3137 NC_010612.1 3822940 3823905 R function unknown role in lipid metabolism; esterase/lipase complement(3822940..3823905) Mycobacterium marinum M 6227404 YP_001851427.1 CDS MMAR_3138 NC_010612.1 3823902 3825419 R function unknown; probably involved in cellular metabolism; monooxygenase complement(3823902..3825419) Mycobacterium marinum M 6227405 YP_001851428.1 CDS MMAR_3139 NC_010612.1 3825467 3826966 R function unknown; involved in cellular metabolism; monooxygenase complement(3825467..3826966) Mycobacterium marinum M 6227406 YP_001851429.1 CDS MMAR_3140 NC_010612.1 3826963 3827886 R hypothetical protein complement(3826963..3827886) Mycobacterium marinum M 6227407 YP_001851430.1 CDS MMAR_3141 NC_010612.1 3827888 3828754 R short-chain membrane-associated dehydrogenase complement(3827888..3828754) Mycobacterium marinum M 6227408 YP_001851431.1 CDS MMAR_3142 NC_010612.1 3828875 3829516 D could be involved in transcriptional mechanism; TetR family transcriptional regulator 3828875..3829516 Mycobacterium marinum M 6227409 YP_001851432.1 CDS MMAR_3143 NC_010612.1 3829683 3830552 R function unknown; contains hydrolase domain; hypothetical protein complement(3829683..3830552) Mycobacterium marinum M 6227410 YP_001851433.1 CDS MMAR_3144 NC_010612.1 3830626 3831315 D could be involved in transcriptional mechanism; AcrR family transcriptional regulator 3830626..3831315 Mycobacterium marinum M 6227411 YP_001851434.1 CDS MMAR_3145 NC_010612.1 3831478 3831786 R hypothetical protein complement(3831478..3831786) Mycobacterium marinum M 6227412 YP_001851435.1 CDS MMAR_3146 NC_010612.1 3831823 3832107 D hypothetical protein 3831823..3832107 Mycobacterium marinum M 6227413 YP_001851436.1 CDS MMAR_3147 NC_010612.1 3832443 3833525 R hypothetical protein complement(3832443..3833525) Mycobacterium marinum M 6227414 YP_001851437.1 CDS MMAR_3148 NC_010612.1 3833522 3834316 R transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 complement(3833522..3834316) Mycobacterium marinum M 6227415 YP_001851438.1 CDS MMAR_3149 NC_010612.1 3834358 3834639 R transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 complement(3834358..3834639) Mycobacterium marinum M 6227416 YP_001851439.1 CDS MMAR_3150 NC_010612.1 3835065 3836171 R thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD- dependent complement(3835065..3836171) Mycobacterium marinum M 6227417 YP_001851440.1 CDS MMAR_3151 NC_010612.1 3836218 3837846 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(3836218..3837846) Mycobacterium marinum M 6227418 YP_001851441.1 CDS MMAR_3152 NC_010612.1 3837883 3838305 R hypothetical protein complement(3837883..3838305) Mycobacterium marinum M 6227419 YP_001851442.1 CDS MMAR_3153 NC_010612.1 3838555 3839757 R ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin reductase complement(3838555..3839757) Mycobacterium marinum M 6227420 YP_001851443.1 CDS cyp153A16 NC_010612.1 3839754 3841145 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 153A16 Cyp153A16 complement(3839754..3841145) Mycobacterium marinum M 6227421 YP_001851444.1 CDS MMAR_3155 NC_010612.1 3841166 3841486 R involved in electron transfer and energy coupling reactions. probably part of an operon including the P450 and ferrodoxin reductase gene products; ferredoxin complement(3841166..3841486) Mycobacterium marinum M 6227422 YP_001851445.1 CDS MMAR_3156 NC_010612.1 3841604 3842614 D involved in transcriptional mechanism; AraC/XylS family transcriptional regulator 3841604..3842614 Mycobacterium marinum M 6227423 YP_001851446.1 CDS MMAR_3158 NC_010612.1 3843257 3843874 R probably involved in a transcriptional mechanism; TetR family transcriptional regulator complement(3843257..3843874) Mycobacterium marinum M 6227425 YP_001851447.1 CDS MMAR_3159 NC_010612.1 3843928 3844839 R function unknown; contains predicted hydrolase or acyltransferase domain (alpha/beta hydrolase superfamily; hydrolase complement(3843928..3844839) Mycobacterium marinum M 6227426 YP_001851448.1 CDS MMAR_3160 NC_010612.1 3844839 3845282 R function unknown; hypothetical protein complement(3844839..3845282) Mycobacterium marinum M 6227427 YP_001851449.1 CDS MMAR_3161 NC_010612.1 3845330 3845944 R involved in transcriptional mechanism; transcriptional regulatory protein complement(3845330..3845944) Mycobacterium marinum M 6227428 YP_001851450.1 CDS MMAR_3162 NC_010612.1 3846064 3846498 D function unknown but contains domain identity with acetyl-CoA acetyltransferase domain, thus possible involvement in lipid metabolism; hypothetical protein 3846064..3846498 Mycobacterium marinum M 6227429 YP_001851451.1 CDS MMAR_3163 NC_010612.1 3846495 3847667 D Zn-dependent alcohol dehydrogenase 3846495..3847667 Mycobacterium marinum M 6227430 YP_001851452.1 CDS MMAR_3164 NC_010612.1 3847630 3848208 D hypothetical protein 3847630..3848208 Mycobacterium marinum M 6227431 YP_001851453.1 CDS MMAR_3165 NC_010612.1 3848464 3848727 R hypothetical protein complement(3848464..3848727) Mycobacterium marinum M 6227432 YP_001851454.1 CDS MMAR_3166 NC_010612.1 3849153 3849587 D function unknown; contains DNA-binding domain; hypothetical protein 3849153..3849587 Mycobacterium marinum M 6227433 YP_001851455.1 CDS MMAR_5567 NC_010612.1 3852426 3852671 D hypothetical protein 3852426..3852671 Mycobacterium marinum M 6227436 YP_001851456.1 CDS MMAR_3170 NC_010612.1 3852808 3853623 R orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form dim; methyltransferase complement(3852808..3853623) Mycobacterium marinum M 6227437 YP_001851457.1 CDS MMAR_5571 NC_010612.1 3854135 3854365 R hypothetical protein complement(3854135..3854365) Mycobacterium marinum M 6227439 YP_001851458.1 CDS mbtH NC_010612.1 3855233 3855463 R thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; protein MbtH complement(3855233..3855463) Mycobacterium marinum M 6227441 YP_001851459.1 CDS mmpL4_5 NC_010612.1 3855755 3858613 R function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(3855755..3858613) Mycobacterium marinum M 6227442 YP_001851460.1 CDS mmpS4 NC_010612.1 3858610 3859008 R membrane protein MmpS4 complement(3858610..3859008) Mycobacterium marinum M 6227443 YP_001851461.1 CDS MMAR_3176 NC_010612.1 3859153 3879816 R production of unknown peptide. contains 5 predicted modules of domain organiszation:Amt, CAMT, cat, cat, CAMT int te. the 'A' domain substrates have not been accurately predicted but probably Phe, Thr or ala); non-ribosomal peptide synthetase complement(3859153..3879816) Mycobacterium marinum M 6227444 YP_001851462.1 CDS panD_2 NC_010612.1 3879856 3880305 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(3879856..3880305) Mycobacterium marinum M 6227445 YP_001851463.1 CDS MMAR_3182 NC_010612.1 3882359 3883300 D function unknown but contains lysophospholipase domain; hypothetical protein 3882359..3883300 Mycobacterium marinum M 6227449 YP_001851464.1 CDS MMAR_3183 NC_010612.1 3883446 3884012 D hypothetical protein 3883446..3884012 Mycobacterium marinum M 6227450 YP_001851465.1 CDS MMAR_3184 NC_010612.1 3884113 3884514 R hypothetical protein complement(3884113..3884514) Mycobacterium marinum M 6227451 YP_001851466.1 CDS wag31 NC_010612.1 3884599 3885393 R function unknown but corresponds to antigen 84 of mycobacterium tuberculosis (Wag31) (see hermans et al., 1995). predicted to contain significant amount of coiled coil structure; secreted antigen Wag31 complement(3884599..3885393) Mycobacterium marinum M 6227452 YP_001851467.1 CDS MMAR_3186 NC_010612.1 3885650 3885937 R hypothetical protein complement(3885650..3885937) Mycobacterium marinum M 6227453 YP_001851468.1 CDS MMAR_3187 NC_010612.1 3886118 3886789 R hypothetical protein complement(3886118..3886789) Mycobacterium marinum M 6227454 YP_001851469.1 CDS MMAR_3188 NC_010612.1 3886854 3887639 R hypothetical protein complement(3886854..3887639) Mycobacterium marinum M 6227455 YP_001851470.1 CDS yfiH NC_010612.1 3887636 3888424 R membrane protein YfiH complement(3887636..3888424) Mycobacterium marinum M 6227456 YP_001851471.1 CDS ftsZ NC_010612.1 3888435 3889595 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(3888435..3889595) Mycobacterium marinum M 6227457 YP_001851472.1 CDS ftsQ NC_010612.1 3889845 3890801 R this protein may be involved in septum formation (by similarity); cell division protein FtsQ complement(3889845..3890801) Mycobacterium marinum M 6227458 YP_001851473.1 CDS murC NC_010612.1 3890798 3892264 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(3890798..3892264) Mycobacterium marinum M 6227459 YP_001851474.1 CDS murG NC_010612.1 3892261 3893460 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase complement(3892261..3893460) Mycobacterium marinum M 6227460 YP_001851475.1 CDS ftsW NC_010612.1 3893457 3895088 R function unknown function in cell division; FtsW-like protein FtsW complement(3893457..3895088) Mycobacterium marinum M 6227461 YP_001851476.1 CDS murD NC_010612.1 3895095 3896561 R UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase complement(3895095..3896561) Mycobacterium marinum M 6227462 YP_001851477.1 CDS mraY NC_010612.1 3896563 3897642 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(3896563..3897642) Mycobacterium marinum M 6227463 YP_001851478.1 CDS murF NC_010612.1 3897639 3899216 R involved in cell wall formation; peptidoglycan biosynthesis; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase MurF complement(3897639..3899216) Mycobacterium marinum M 6227464 YP_001851479.1 CDS murE NC_010612.1 3899213 3900778 R involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(3899213..3900778) Mycobacterium marinum M 6227465 YP_001851480.1 CDS MMAR_3199 NC_010612.1 3901182 3902975 R PE-PGRS family protein complement(3901182..3902975) Mycobacterium marinum M 6227466 YP_001851481.1 CDS pbpB NC_010612.1 3903227 3905302 R involved in peptidoglycan biosynthesis; penicillin-binding membrane protein PbpB complement(3903227..3905302) Mycobacterium marinum M 6227467 YP_001851482.1 CDS MMAR_3201 NC_010612.1 3905299 3906576 R proline rich membrane protein complement(3905299..3906576) Mycobacterium marinum M 6227468 YP_001851483.1 CDS mraW NC_010612.1 3906573 3907610 R S-adenosyl-methyltransferase MraW complement(3906573..3907610) Mycobacterium marinum M 6227469 YP_001851484.1 CDS MMAR_3203 NC_010612.1 3907762 3908217 R MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ complement(3907762..3908217) Mycobacterium marinum M 6227470 YP_001851485.1 CDS MMAR_3204 NC_010612.1 3908602 3909006 R hypothetical protein complement(3908602..3909006) Mycobacterium marinum M 6227471 YP_001851486.1 CDS MMAR_3205 NC_010612.1 3909309 3909947 D function unknown but contains acyl-CoA N- acyltransferase superfamily domain; hypothetical protein 3909309..3909947 Mycobacterium marinum M 6227472 YP_001851487.1 CDS lppM NC_010612.1 3910016 3910744 D lipoprotein LppM 3910016..3910744 Mycobacterium marinum M 6227473 YP_001851488.1 CDS MMAR_3207 NC_010612.1 3910790 3911686 R hypothetical protein complement(3910790..3911686) Mycobacterium marinum M 6227474 YP_001851489.1 CDS idsA2 NC_010612.1 3912008 3913030 D involved in lipid biosynthesis; geranylgeranyl pyrophosphate synthase 3912008..3913030 Mycobacterium marinum M 6227475 YP_001851490.1 CDS MMAR_3209 NC_010612.1 3913035 3914615 D hypothetical protein 3913035..3914615 Mycobacterium marinum M 6227476 YP_001851491.1 CDS MMAR_3210 NC_010612.1 3914653 3915057 R regulatory protein complement(3914653..3915057) Mycobacterium marinum M 6227477 YP_001851492.1 CDS pknL NC_010612.1 3915148 3916443 D involved in signal transduction (via phosphorylation); Ser/Thr protein kinase 3915148..3916443 Mycobacterium marinum M 6227478 YP_001851493.1 CDS idsB_2 NC_010612.1 3916508 3917545 R involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; polyprenyl synthetase IdsB_2 complement(3916508..3917545) Mycobacterium marinum M 6227479 YP_001851494.1 CDS pksG NC_010612.1 3917562 3918728 R part of the mevalonate pathway for isoprenoid synthesis: conversion: acetyl-CoA + H(2)O + acetoacetyl- CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + CoA; hydroxymethylglutaryl-coenzyme A synthase, PksG complement(3917562..3918728) Mycobacterium marinum M 6227480 YP_001851495.1 CDS MMAR_3214 NC_010612.1 3918774 3919829 R HMGR is a tightly regulated enzyme, which catalyzes the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. in mammals, this is the rate limiting committed step in cholesterol biosynthesis. bacteria, such as pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3- hydroxy-3-methylglutaryl-CoA; hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase complement(3918774..3919829) Mycobacterium marinum M 6227481 YP_001851496.1 CDS MMAR_3215 NC_010612.1 3919853 3920965 R part of the mevalonate pathway for isoprenoid synthesis. possible regulatory role in mevalonate metabolism. converts (R)-5-phosphomevalonate to (R)-5- diphosphomevalonate; phosphomevalonate kinase complement(3919853..3920965) Mycobacterium marinum M 6227482 YP_001851497.1 CDS MMAR_3216 NC_010612.1 3920962 3921972 R key enzyme in isoprenoid synthesis. converts (R)-5- diphosphomevalonate to phosphate + isopentenyl diphosphate + CO(2); diphosphomevalonate decarboxylase complement(3920962..3921972) Mycobacterium marinum M 6227483 YP_001851498.1 CDS erg12 NC_010612.1 3921969 3922967 R converts (R)-mevalonate to (R)-5-phosphomevalonate (ATP dependant); mevalonate kinase, Erg12 complement(3921969..3922967) Mycobacterium marinum M 6227484 YP_001851499.1 CDS idi NC_010612.1 3922982 3923506 R catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase complement(3922982..3923506) Mycobacterium marinum M 6227485 YP_001851500.1 CDS idsB_1 NC_010612.1 3923702 3924739 R involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; polyprenyl synthetase IdsB complement(3923702..3924739) Mycobacterium marinum M 6227486 YP_001851501.1 CDS MMAR_3220 NC_010612.1 3925352 3926368 D function unknown but possibly involved in catalysis of cyclisation cascades involving polyisoprene substrates; terpene cyclase 3925352..3926368 Mycobacterium marinum M 6227487 YP_001851502.1 CDS fabH_1 NC_010612.1 3926695 3927738 D involved in fatty acid biosynthesis. catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl- acp. kas III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. possesses both acetoacetyl-acp synthase and acetyl transacylase activities [catalytic activity: acyl- [acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]]; 3-oxoacyl-ACP synthase 3926695..3927738 Mycobacterium marinum M 6227488 YP_001851503.1 CDS aroG NC_010612.1 3927931 3929319 R involved in chorismate biosynthesis; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase complement(3927931..3929319) Mycobacterium marinum M 6227489 YP_001851504.1 CDS MMAR_3223 NC_010612.1 3929368 3929847 R hypothetical protein complement(3929368..3929847) Mycobacterium marinum M 6227490 YP_001851505.1 CDS MMAR_3224 NC_010612.1 3929857 3930723 R hypothetical protein complement(3929857..3930723) Mycobacterium marinum M 6227491 YP_001851506.1 CDS MMAR_3225 NC_010612.1 3930815 3932098 D hypothetical protein 3930815..3932098 Mycobacterium marinum M 6227492 YP_001851507.1 CDS MMAR_3226 NC_010612.1 3932099 3932830 R transfer of fatty acyl groups; 1-acylglycerol-3-phosphate O-acyltransferase complement(3932099..3932830) Mycobacterium marinum M 6227493 YP_001851508.1 CDS MMAR_3227 NC_010612.1 3932918 3933307 R hypothetical protein complement(3932918..3933307) Mycobacterium marinum M 6227494 YP_001851509.1 CDS MMAR_3228 NC_010612.1 3933304 3934503 R function unknown but domain identity suggests it is an anion-transporting ATPase; hypothetical protein complement(3933304..3934503) Mycobacterium marinum M 6227495 YP_001851510.1 CDS MMAR_3229 NC_010612.1 3934575 3935009 R hypothetical protein complement(3934575..3935009) Mycobacterium marinum M 6227496 YP_001851511.1 CDS MMAR_3230 NC_010612.1 3935106 3935495 R hypothetical protein complement(3935106..3935495) Mycobacterium marinum M 6227497 YP_001851512.1 CDS fadD15 NC_010612.1 3935705 3937507 D function unknown, but involved in lipid metabolism; long-chain-fatty-acid-CoA ligase FadD15 3935705..3937507 Mycobacterium marinum M 6227498 YP_001851513.1 CDS MMAR_3232 NC_010612.1 3937803 3938960 R glycosyltransferase complement(3937803..3938960) Mycobacterium marinum M 6227499 YP_001851514.1 CDS MMAR_3233 NC_010612.1 3939032 3939889 R hypothetical protein complement(3939032..3939889) Mycobacterium marinum M 6227500 YP_001851515.1 CDS MMAR_3234 NC_010612.1 3939903 3941063 R hypothetical protein complement(3939903..3941063) Mycobacterium marinum M 6227501 YP_001851516.1 CDS MMAR_5560 NC_010612.1 3941238 3941492 R hypothetical protein complement(3941238..3941492) Mycobacterium marinum M 6227502 YP_001851517.1 CDS MMAR_3235 NC_010612.1 3941645 3943669 D contains 3'-5'exonuclease domain; hypothetical protein 3941645..3943669 Mycobacterium marinum M 6227503 YP_001851518.1 CDS trpD NC_010612.1 3943544 3944647 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(3943544..3944647) Mycobacterium marinum M 6227504 YP_001851519.1 CDS ctaE NC_010612.1 3944798 3945409 D thought to be involved in aerobic respiration; cytochrome C oxidase (subunit III) CtaE 3944798..3945409 Mycobacterium marinum M 6227505 YP_001851520.1 CDS qcrC NC_010612.1 3945462 3946367 D plays a role in aerobic respiration; ubiquinol-cytochrome C reductase QcrC 3945462..3946367 Mycobacterium marinum M 6227506 YP_001851521.1 CDS qcrA NC_010612.1 3946364 3947548 D role in respiration; Rieske iron-sulfur protein QcrA 3946364..3947548 Mycobacterium marinum M 6227507 YP_001851522.1 CDS qcrB NC_010612.1 3947545 3949230 D role in respiration; ubiquinol-cytochrome C reductase QcrB 3947545..3949230 Mycobacterium marinum M 6227508 YP_001851523.1 CDS MMAR_3241 NC_010612.1 3949676 3950314 R transmembrane protein complement(3949676..3950314) Mycobacterium marinum M 6227509 YP_001851524.1 CDS mmpS3 NC_010612.1 3950314 3951261 R membrane protein MmpS3 complement(3950314..3951261) Mycobacterium marinum M 6227510 YP_001851525.1 CDS MMAR_3243 NC_010612.1 3951444 3951863 R integral membrane protein complement(3951444..3951863) Mycobacterium marinum M 6227511 YP_001851526.1 CDS ctaC NC_010612.1 3951872 3952975 R involved in aerobic respiration. subunit I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE a and cu(a) to the binuclear center formed by HemE A3 and cu(B) (by similarity); transmembrane cytochrome C oxidase (subunit II) CtaC complement(3951872..3952975) Mycobacterium marinum M 6227512 YP_001851527.1 CDS asnB NC_010612.1 3953372 3955366 D asparagine biosynthesis; asparagine synthetase AsnB 3953372..3955366 Mycobacterium marinum M 6227513 YP_001851528.1 CDS cbhK NC_010612.1 3955379 3956353 R phosphorylation of carbohydrates; carbohydrate kinase CbhK complement(3955379..3956353) Mycobacterium marinum M 6227514 YP_001851529.1 CDS MMAR_3247 NC_010612.1 3956545 3957234 D hypothetical protein 3956545..3957234 Mycobacterium marinum M 6227515 YP_001851530.1 CDS MMAR_3248 NC_010612.1 3957275 3957631 R function unknown but domain identity shows similarity to the HesB gene (function unknown) but which is expressed only under nitrogen fixation conditions; hypothetical protein complement(3957275..3957631) Mycobacterium marinum M 6227516 YP_001851531.1 CDS MMAR_3249 NC_010612.1 3957717 3958862 R function unknown role in carbohydrate transport and metabolism; glycerate kinase complement(3957717..3958862) Mycobacterium marinum M 6227517 YP_001851532.1 CDS MMAR_3250 NC_010612.1 3958955 3959659 D transmembrane protein 3958955..3959659 Mycobacterium marinum M 6227518 YP_001851533.1 CDS cobU NC_010612.1 3959688 3960248 D involved in cobalamin biosynthesis; bifunctional cobalamin biosynthesis protein CobU 3959688..3960248 Mycobacterium marinum M 6227519 YP_001851534.1 CDS cobT NC_010612.1 3960245 3961321 D catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 3960245..3961321 Mycobacterium marinum M 6227520 YP_001851535.1 CDS cobS NC_010612.1 3961318 3962076 D catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 3961318..3962076 Mycobacterium marinum M 6227521 YP_001851536.1 CDS MMAR_3254 NC_010612.1 3962266 3963762 D function unknown but domain identity with chloride channel superfamily; hypothetical protein 3962266..3963762 Mycobacterium marinum M 6227522 YP_001851537.1 CDS ilvE NC_010612.1 3963754 3964860 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(3963754..3964860) Mycobacterium marinum M 6227523 YP_001851538.1 CDS gcvT NC_010612.1 3964915 3966018 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3964915..3966018) Mycobacterium marinum M 6227524 YP_001851539.1 CDS MMAR_3257 NC_010612.1 3966063 3967208 D adenylate cyclase 3966063..3967208 Mycobacterium marinum M 6227525 YP_001851540.1 CDS pepB NC_010612.1 3967220 3968779 D catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 3967220..3968779 Mycobacterium marinum M 6227526 YP_001851541.1 CDS ephD NC_010612.1 3969244 3971028 R thought to be involved in detoxification reactions following oxidative damage to lipids; short chain dehydrogenase complement(3969244..3971028) Mycobacterium marinum M 6227527 YP_001851542.1 CDS sucB NC_010612.1 3971257 3973023 D involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2; dihydrolipoamide acetyltransferase 3971257..3973023 Mycobacterium marinum M 6227528 YP_001851543.1 CDS MMAR_3261 NC_010612.1 3973028 3973939 D function unknown but domain identity with NAD dependent sugar epimerases; hypothetical protein 3973028..3973939 Mycobacterium marinum M 6227529 YP_001851544.1 CDS MMAR_3262 NC_010612.1 3974086 3974850 R function unknown role in substrate movement; integral membrane protein ABC transporter complement(3974086..3974850) Mycobacterium marinum M 6227530 YP_001851545.1 CDS MMAR_3263 NC_010612.1 3974940 3975905 R probably involved in active transport of substrate across the membrane (export). responsible for energy coupling to the transport system; ABC transporter ATP-binding protein complement(3974940..3975905) Mycobacterium marinum M 6227531 YP_001851546.1 CDS MMAR_3264 NC_010612.1 3976045 3978954 R thought to be involved in fatty acid transport; MmpL family transport protein complement(3976045..3978954) Mycobacterium marinum M 6227532 YP_001851547.1 CDS MMAR_3265 NC_010612.1 3979389 3979619 R MbtH-like protein complement(3979389..3979619) Mycobacterium marinum M 6227533 YP_001851548.1 CDS MMAR_3266 NC_010612.1 3979902 3982811 R thought to be involved in fatty acid transport; MmpL family transport protein complement(3979902..3982811) Mycobacterium marinum M 6227534 YP_001851549.1 CDS MMAR_3267 NC_010612.1 3982808 3983197 R transmembrane protein complement(3982808..3983197) Mycobacterium marinum M 6227535 YP_001851550.1 CDS MMAR_3268 NC_010612.1 3984467 4014043 D involved in lipid metabolism. nine ext. modules, each module with predicted domain structure of C,a,T, domains ending in an integral te domain; non-ribosomal peptide synthetase 3984467..4014043 Mycobacterium marinum M 6227536 YP_001851551.1 CDS MMAR_3270 NC_010612.1 4017092 4023604 D synthesis of unknown metabolite. predicted structure: two extension modules, each with C, a & T domains. possible Thr & arg substrate; non-ribosomal peptide synthetase 4017092..4023604 Mycobacterium marinum M 6227538 YP_001851552.1 CDS MMAR_3271 NC_010612.1 4023706 4037001 D synthesis of unknown peptide - four predicted extension modules, each with domain structure C, a & T. final extension module End with an integral te domain. predicted, respective substrate specificity for each module: ThrE, Orn-D, arg, ThrE; non-ribosomal peptide synthetase 4023706..4037001 Mycobacterium marinum M 6227539 YP_001851553.1 CDS MMAR_3272 NC_010612.1 4037157 4038782 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(4037157..4038782) Mycobacterium marinum M 6227540 YP_001851554.1 CDS MMAR_3273 NC_010612.1 4039155 4039451 R function unknown; contains a phosphopantetheine attachment site, thus probably plays a role in this Nrp operon, perhaps for synthesis of a NRP/PKS fusion; hypothetical protein complement(4039155..4039451) Mycobacterium marinum M 6227541 YP_001851555.1 CDS MMAR_3274 NC_010612.1 4040050 4040277 D hypothetical protein 4040050..4040277 Mycobacterium marinum M 6227542 YP_001851556.1 CDS MMAR_3275 NC_010612.1 4040385 4040921 R hypothetical protein complement(4040385..4040921) Mycobacterium marinum M 6227543 YP_001851557.1 CDS MMAR_3276 NC_010612.1 4041056 4041709 D the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; alternative RNA polymerase sigma factor 4041056..4041709 Mycobacterium marinum M 6227544 YP_001851558.1 CDS MMAR_3277 NC_010612.1 4041699 4041983 D hypothetical protein 4041699..4041983 Mycobacterium marinum M 6227545 YP_001851559.1 CDS wrbA NC_010612.1 4042510 4043262 D multimeric flavodoxin WrbA 4042510..4043262 Mycobacterium marinum M 6227546 YP_001851560.1 CDS MMAR_3279 NC_010612.1 4043295 4044134 D hypothetical protein 4043295..4044134 Mycobacterium marinum M 6227547 YP_001851561.1 CDS MMAR_3280 NC_010612.1 4044166 4044825 D function unknown, may have methyltransferase activity; hypothetical protein 4044166..4044825 Mycobacterium marinum M 6227548 YP_001851562.1 CDS ilvB1_2 NC_010612.1 4044825 4046501 D involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate]; acetolactate synthase large subunit IlvB 4044825..4046501 Mycobacterium marinum M 6227549 YP_001851563.1 CDS MMAR_3282 NC_010612.1 4046526 4046918 R hypothetical protein complement(4046526..4046918) Mycobacterium marinum M 6227550 YP_001851564.1 CDS MMAR_3283 NC_010612.1 4047002 4049158 R thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; drug-transport transmembrane ABC transporter ATP-binding protein complement(4047002..4049158) Mycobacterium marinum M 6227551 YP_001851565.1 CDS MMAR_3284 NC_010612.1 4049331 4051172 R thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; drug-transport transmembrane ABC transporter ATP-binding protein complement(4049331..4051172) Mycobacterium marinum M 6227552 YP_001851566.1 CDS lipB NC_010612.1 4051333 4052058 D lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 4051333..4052058 Mycobacterium marinum M 6227553 YP_001851567.1 CDS lipA NC_010612.1 4052055 4053029 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 4052055..4053029 Mycobacterium marinum M 6227554 YP_001851568.1 CDS MMAR_3287 NC_010612.1 4053056 4053808 D transmembrane protein 4053056..4053808 Mycobacterium marinum M 6227555 YP_001851569.1 CDS MMAR_3288 NC_010612.1 4053858 4054280 R hypothetical protein complement(4053858..4054280) Mycobacterium marinum M 6227556 YP_001851570.1 CDS glnA1 NC_010612.1 4054523 4055959 D involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]; glutamine synthetase GlnA1 4054523..4055959 Mycobacterium marinum M 6227557 YP_001851571.1 CDS MMAR_3290 NC_010612.1 4056223 4058403 D function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection; PE-PGRS family protein 4056223..4058403 Mycobacterium marinum M 6227558 YP_001851572.1 CDS MMAR_3291 NC_010612.1 4058448 4059308 R function unknown, probably involved in cellular metabolism; hypothetical protein complement(4058448..4059308) Mycobacterium marinum M 6227559 YP_001851573.1 CDS MMAR_3292 NC_010612.1 4059305 4059943 R hypothetical protein complement(4059305..4059943) Mycobacterium marinum M 6227560 YP_001851574.1 CDS glnE NC_010612.1 4059957 4062944 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(4059957..4062944) Mycobacterium marinum M 6227561 YP_001851575.1 CDS glnA2 NC_010612.1 4063015 4064355 R involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]; glutamine synthetase complement(4063015..4064355) Mycobacterium marinum M 6227562 YP_001851576.1 CDS MMAR_3295 NC_010612.1 4064445 4066025 R function unknown; thought to hydrolyze peptides and/or proteins; exported protease complement(4064445..4066025) Mycobacterium marinum M 6227563 YP_001851577.1 CDS ctaD_1 NC_010612.1 4066074 4067807 R cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C]; cytochrome C oxidase polypeptide I CtaD complement(4066074..4067807) Mycobacterium marinum M 6227564 YP_001851578.1 CDS MMAR_3297 NC_010612.1 4067951 4069507 R function unknown; thought to hydrolyze peptides and/or proteins; exported protease complement(4067951..4069507) Mycobacterium marinum M 6227565 YP_001851579.1 CDS MMAR_3298 NC_010612.1 4069567 4070958 R hypothetical protein complement(4069567..4070958) Mycobacterium marinum M 6227566 YP_001851580.1 CDS panB NC_010612.1 4071106 4071999 D catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 4071106..4071999 Mycobacterium marinum M 6227567 YP_001851581.1 CDS MMAR_3300 NC_010612.1 4072007 4072519 R hypothetical protein complement(4072007..4072519) Mycobacterium marinum M 6227568 YP_001851582.1 CDS MMAR_3301 NC_010612.1 4072592 4074184 D hypothetical protein 4072592..4074184 Mycobacterium marinum M 6227569 YP_001851583.1 CDS MMAR_3302 NC_010612.1 4074778 4075587 D hypothetical protein 4074778..4075587 Mycobacterium marinum M 6227570 YP_001851584.1 CDS MMAR_3303 NC_010612.1 4075650 4078139 R function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein complement(4075650..4078139) Mycobacterium marinum M 6227571 YP_001851585.1 CDS MMAR_3304 NC_010612.1 4079095 4080219 R bifunctional RNase H/acid phosphatase complement(4079095..4080219) Mycobacterium marinum M 6227573 YP_001851586.1 CDS MMAR_3305 NC_010612.1 4080216 4080953 R hypothetical protein complement(4080216..4080953) Mycobacterium marinum M 6227574 YP_001851587.1 CDS MMAR_3306 NC_010612.1 4080976 4082112 R hypothetical protein complement(4080976..4082112) Mycobacterium marinum M 6227575 YP_001851588.1 CDS cobC NC_010612.1 4082109 4083161 R involved in cobalamin biosynthesis; hypothetical protein complement(4082109..4083161) Mycobacterium marinum M 6227576 YP_001851589.1 CDS MMAR_3308 NC_010612.1 4083439 4084071 D hypothetical protein 4083439..4084071 Mycobacterium marinum M 6227577 YP_001851590.1 CDS ptpA NC_010612.1 4084064 4084558 D involved in signal transduction (via dephosphorylation). can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0 [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate; phosphotyrosine protein phosphatase PtpA 4084064..4084558 Mycobacterium marinum M 6227578 YP_001851591.1 CDS MMAR_3310 NC_010612.1 4084558 4085382 D function unknown: may be involved in the ability to survive in macrophages; transmembrane protein 4084558..4085382 Mycobacterium marinum M 6227579 YP_001851592.1 CDS cobD NC_010612.1 4085364 4086305 R CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein complement(4085364..4086305) Mycobacterium marinum M 6227580 YP_001851593.1 CDS MMAR_3312 NC_010612.1 4086419 4087234 D hypothetical protein 4086419..4087234 Mycobacterium marinum M 6227581 YP_001851594.1 CDS MMAR_3313 NC_010612.1 4087255 4088184 R function unknown; possibly involved in transport of metal ions across the membrane; hypothetical protein complement(4087255..4088184) Mycobacterium marinum M 6227582 YP_001851595.1 CDS MMAR_3314 NC_010612.1 4088273 4089397 R function unknown; contains high domain identity with epoxide hydrolases. they comprise a group of functionally related enzymes that catalyse the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. in animals, the major interest in eh is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three- membered ring system and the strong polarisation of the C-- O bonds. this is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. this family is often found in conjunction with pfam00561; hydrolase complement(4088273..4089397) Mycobacterium marinum M 6227583 YP_001851596.1 CDS MMAR_3315 NC_010612.1 4089537 4090943 D transposition of ISMyma07; transposase for ISMyma07 4089537..4090943 Mycobacterium marinum M 6227584 YP_001851597.1 CDS MMAR_3316 NC_010612.1 4091225 4094122 D PE-PGRS family protein 4091225..4094122 Mycobacterium marinum M 6227585 YP_001851598.1 CDS MMAR_3317 NC_010612.1 4094242 4095648 D transposition of ISMyma07; transposase for ISMyma07 4094242..4095648 Mycobacterium marinum M 6227586 YP_001851599.1 CDS MMAR_3318 NC_010612.1 4095830 4096024 R hypothetical protein complement(4095830..4096024) Mycobacterium marinum M 6227587 YP_001851600.1 CDS MMAR_3319 NC_010612.1 4096159 4097169 R function unknown; probably involved in cellular metabolism; dehydrogenase complement(4096159..4097169) Mycobacterium marinum M 6227588 YP_001851601.1 CDS MMAR_3320 NC_010612.1 4097273 4098307 R involved in transcriptional mechanism; AraC/XylS family transcriptional regulator complement(4097273..4098307) Mycobacterium marinum M 6227589 YP_001851602.1 CDS MMAR_3321 NC_010612.1 4098380 4099801 R function unknown; contains a putative glyoxylase domain; hypothetical protein complement(4098380..4099801) Mycobacterium marinum M 6227590 YP_001851603.1 CDS MMAR_3322 NC_010612.1 4099812 4100825 R involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (beta subunit) complement(4099812..4100825) Mycobacterium marinum M 6227591 YP_001851604.1 CDS MMAR_3323 NC_010612.1 4100822 4101883 R involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (alpha subunit) complement(4100822..4101883) Mycobacterium marinum M 6227592 YP_001851605.1 CDS MMAR_3324 NC_010612.1 4101943 4102944 R function unknown; nucleoside-diphosphate-sugar epimerase complement(4101943..4102944) Mycobacterium marinum M 6227593 YP_001851606.1 CDS MMAR_3325 NC_010612.1 4103313 4103873 D hypothetical protein 4103313..4103873 Mycobacterium marinum M 6227594 YP_001851607.1 CDS MMAR_3326 NC_010612.1 4104294 4106909 D PE-PGRS family protein 4104294..4106909 Mycobacterium marinum M 6227595 YP_001851608.1 CDS MMAR_3327 NC_010612.1 4107086 4107646 D hypothetical protein 4107086..4107646 Mycobacterium marinum M 6227596 YP_001851609.1 CDS adhE2_1 NC_010612.1 4107646 4108728 D oxido-reduction; zinc-dependent alcohol dehydrogenase AdhE2 4107646..4108728 Mycobacterium marinum M 6227597 YP_001851610.1 CDS MMAR_3329 NC_010612.1 4108765 4110237 D hypothetical protein 4108765..4110237 Mycobacterium marinum M 6227598 YP_001851611.1 CDS MMAR_3330 NC_010612.1 4110234 4111784 D hypothetical protein 4110234..4111784 Mycobacterium marinum M 6227599 YP_001851612.1 CDS ahpE NC_010612.1 4111923 4112384 R detoxification of organic peroxides; peroxiredoxin AhpE complement(4111923..4112384) Mycobacterium marinum M 6227601 YP_001851613.1 CDS MMAR_3332 NC_010612.1 4112384 4112830 R hypothetical protein complement(4112384..4112830) Mycobacterium marinum M 6227602 YP_001851614.1 CDS MMAR_3333 NC_010612.1 4112887 4113489 R N-term truncated (missing first 69aa) compared to M. tuberculosis; hypothetical protein complement(4112887..4113489) Mycobacterium marinum M 6227603 YP_001851615.1 CDS aceE NC_010612.1 4113674 4116463 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 4113674..4116463 Mycobacterium marinum M 6227604 YP_001851616.1 CDS MMAR_3335 NC_010612.1 4116597 4117907 D hypothetical protein 4116597..4117907 Mycobacterium marinum M 6227605 YP_001851617.1 CDS fabD NC_010612.1 4118069 4118977 D catalyzes malonyl-CoA-acp transacylase (McaT) activity using holo-AcpM as substrate for transacylation [catalytic activity: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]; malonyl CoA-acyl carrier protein transacylase FabD 4118069..4118977 Mycobacterium marinum M 6227606 YP_001851618.1 CDS acpP NC_010612.1 4119050 4119397 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 4119050..4119397 Mycobacterium marinum M 6227607 YP_001851619.1 CDS kasA NC_010612.1 4119394 4120644 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 4119394..4120644 Mycobacterium marinum M 6227608 YP_001851620.1 CDS kasB NC_010612.1 4120726 4121979 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 4120726..4121979 Mycobacterium marinum M 6227609 YP_001851621.1 CDS accD6 NC_010612.1 4122017 4123438 D involved in fatty acid biosynthesis (mycolic acids synthesis) [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl- CoA]; acetyl/propionyl CoA carboxylase subunit beta 4122017..4123438 Mycobacterium marinum M 6227610 YP_001851622.1 CDS MMAR_3341 NC_010612.1 4123564 4124451 D hypothetical protein 4123564..4124451 Mycobacterium marinum M 6227611 YP_001851623.1 CDS glpD1 NC_010612.1 4124532 4126067 R involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor]; glycerol-3-phosphate dehydrogenase complement(4124532..4126067) Mycobacterium marinum M 6227612 YP_001851624.1 CDS MMAR_3343 NC_010612.1 4126067 4126636 R possibly involved in transcriptional regulation; transcriptional regulatory protein complement(4126067..4126636) Mycobacterium marinum M 6227613 YP_001851625.1 CDS MMAR_3344 NC_010612.1 4126684 4128264 D electron acceptor; flavoprotein 4126684..4128264 Mycobacterium marinum M 6227614 YP_001851626.1 CDS MMAR_3345 NC_010612.1 4128261 4129223 D involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids; diacylglycerol kinase 4128261..4129223 Mycobacterium marinum M 6227615 YP_001851627.1 CDS MMAR_3346 NC_010612.1 4129346 4129864 D hypothetical protein 4129346..4129864 Mycobacterium marinum M 6227616 YP_001851628.1 CDS MMAR_3347 NC_010612.1 4129870 4130382 R hypothetical protein complement(4129870..4130382) Mycobacterium marinum M 6227617 YP_001851629.1 CDS MMAR_3348 NC_010612.1 4130536 4131354 R hypothetical protein complement(4130536..4131354) Mycobacterium marinum M 6227618 YP_001851630.1 CDS MMAR_3349 NC_010612.1 4131367 4132437 R possibly involved in transcriptional regulation; transcriptional regulatory protein complement(4131367..4132437) Mycobacterium marinum M 6227619 YP_001851631.1 CDS adhE2 NC_010612.1 4132568 4133653 D oxido-reduction; zinc-dependent alcohol dehydrogenase AdhE2 4132568..4133653 Mycobacterium marinum M 6227620 YP_001851632.1 CDS MMAR_3351 NC_010612.1 4133653 4134276 D hypothetical protein 4133653..4134276 Mycobacterium marinum M 6227621 YP_001851633.1 CDS MMAR_3352 NC_010612.1 4134439 4135836 R transposition of insertion sequence element ISMyma02; transposase for insertion sequence ISMyma02 complement(4134439..4135836) Mycobacterium marinum M 6227622 YP_001851634.1 CDS MMAR_3353 NC_010612.1 4136022 4136771 R function unknown; hypothetical protein complement(4136022..4136771) Mycobacterium marinum M 6227623 YP_001851635.1 CDS lnt NC_010612.1 4136768 4138216 R Predicted to be involved in lipoprotein acylation; apolipoprotein n-acyltransferase, Lnt complement(4136768..4138216) Mycobacterium marinum M 6227624 YP_001851636.1 CDS MMAR_3355 NC_010612.1 4138353 4139306 D oxidoreduction; short chain dehydrogenase 4138353..4139306 Mycobacterium marinum M 6227625 YP_001851637.1 CDS MMAR_3356 NC_010612.1 4139308 4140414 D hypothetical protein 4139308..4140414 Mycobacterium marinum M 6227626 YP_001851638.1 CDS MMAR_3357 NC_010612.1 4140509 4140865 D function unknown; hypothetical protein 4140509..4140865 Mycobacterium marinum M 6227627 YP_001851639.1 CDS MMAR_3358 NC_010612.1 4140889 4142826 R hypothetical protein complement(4140889..4142826) Mycobacterium marinum M 6227628 YP_001851640.1 CDS MMAR_3359 NC_010612.1 4142958 4144043 R hypothetical protein complement(4142958..4144043) Mycobacterium marinum M 6227629 YP_001851641.1 CDS mmpS5_2 NC_010612.1 4144258 4144596 D transmembrane protein, MmpS5_2 4144258..4144596 Mycobacterium marinum M 6227630 YP_001851642.1 CDS cyp124A1 NC_010612.1 4144702 4146003 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 124A1, Cyp124A1 4144702..4146003 Mycobacterium marinum M 6227631 YP_001851643.1 CDS aofH_1 NC_010612.1 4146037 4147410 D possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]. must have important function in metabolism. supposed involved in stationary- phase survival; flavin-containing monoamine oxidase AofH 4146037..4147410 Mycobacterium marinum M 6227632 YP_001851644.1 CDS MMAR_3363 NC_010612.1 4147419 4148045 R hypothetical protein complement(4147419..4148045) Mycobacterium marinum M 6227633 YP_001851645.1 CDS MMAR_3364 NC_010612.1 4148139 4149326 R function unknown; hypothetical protein complement(4148139..4149326) Mycobacterium marinum M 6227634 YP_001851646.1 CDS MMAR_3365 NC_010612.1 4149514 4150071 D hypothetical protein 4149514..4150071 Mycobacterium marinum M 6227635 YP_001851647.1 CDS lppN NC_010612.1 4150140 4150673 D lipoprotein LppN 4150140..4150673 Mycobacterium marinum M 6227636 YP_001851648.1 CDS MMAR_3367 NC_010612.1 4150670 4151068 D hypothetical protein 4150670..4151068 Mycobacterium marinum M 6227637 YP_001851649.1 CDS MMAR_3368 NC_010612.1 4151267 4151644 D transmembrane protein 4151267..4151644 Mycobacterium marinum M 6227638 YP_001851650.1 CDS MMAR_3369 NC_010612.1 4151641 4151976 D function unknown; transmembrane protein 4151641..4151976 Mycobacterium marinum M 6227639 YP_001851651.1 CDS MMAR_3370 NC_010612.1 4152000 4152734 R function unknown, in general, cation channels are transport proteins responsible for the movement of cations through the membrane; ion transport protein complement(4152000..4152734) Mycobacterium marinum M 6227640 YP_001851652.1 CDS MMAR_3371 NC_010612.1 4152886 4153596 R function unknown; predicted hydrolase (had superfamily) domain; hypothetical protein complement(4152886..4153596) Mycobacterium marinum M 6227641 YP_001851653.1 CDS MMAR_3372 NC_010612.1 4153682 4153963 D transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 4153682..4153963 Mycobacterium marinum M 6227642 YP_001851654.1 CDS MMAR_3373 NC_010612.1 4154005 4154799 D transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 4154005..4154799 Mycobacterium marinum M 6227643 YP_001851655.1 CDS MMAR_3374 NC_010612.1 4154960 4155430 R hypothetical protein complement(4154960..4155430) Mycobacterium marinum M 6227644 YP_001851656.1 CDS MMAR_3375 NC_010612.1 4155454 4156461 R hypothetical protein complement(4155454..4156461) Mycobacterium marinum M 6227645 YP_001851657.1 CDS MMAR_3376 NC_010612.1 4157159 4157638 R contains PTPS, 6-pyruvoyl tetrahydropterin synthase domain. 6-pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6- pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. the functional enzyme is a hexamer of identical subunits; 6-pyruvoyl tetrahydrobiopterin synthase complement(4157159..4157638) Mycobacterium marinum M 6227646 YP_001851658.1 CDS MMAR_3377 NC_010612.1 4158033 4158188 R hypothetical protein complement(4158033..4158188) Mycobacterium marinum M 6227647 YP_001851659.1 CDS MMAR_3378 NC_010612.1 4158378 4159550 R PPE family protein complement(4158378..4159550) Mycobacterium marinum M 6227648 YP_001851660.1 CDS MMAR_3379 NC_010612.1 4159597 4160790 R PPE family protein complement(4159597..4160790) Mycobacterium marinum M 6227649 YP_001851661.1 CDS MMAR_3380 NC_010612.1 4161654 4161866 R transposition of an insertion sequence; transposase ISMyma01_aa1-like protein complement(4161654..4161866) Mycobacterium marinum M 6227651 YP_001851662.1 CDS MMAR_3381 NC_010612.1 4162042 4163643 R hypothetical protein complement(4162042..4163643) Mycobacterium marinum M 6227652 YP_001851663.1 CDS MMAR_3382 NC_010612.1 4163700 4164473 R hypothetical protein complement(4163700..4164473) Mycobacterium marinum M 6227653 YP_001851664.1 CDS MMAR_3383 NC_010612.1 4165091 4165882 D FabG-like dehydrogenase 4165091..4165882 Mycobacterium marinum M 6227654 YP_001851665.1 CDS MMAR_3384 NC_010612.1 4165983 4167638 D function unknown but contains identity with hydroxylase domain; hydroxylase 4165983..4167638 Mycobacterium marinum M 6227655 YP_001851666.1 CDS MMAR_3385 NC_010612.1 4167635 4168903 D hypothetical protein 4167635..4168903 Mycobacterium marinum M 6227656 YP_001851667.1 CDS pmiA NC_010612.1 4169863 4170456 D Involved in synthesis of cell wall components that are required to inhibit phagosome maturation; Phagosome maturation inhibitor, PmiA 4169863..4170456 Mycobacterium marinum M 6227657 YP_001851668.1 CDS MMAR_3387 NC_010612.1 4170703 4171899 R domain identity with beta-lactamase class C and other penicillin binding proteins; hypothetical protein complement(4170703..4171899) Mycobacterium marinum M 6227658 YP_001851669.1 CDS MMAR_3388 NC_010612.1 4171896 4173374 R an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; biotin carboxylase-like protein complement(4171896..4173374) Mycobacterium marinum M 6227659 YP_001851670.1 CDS MMAR_3389 NC_010612.1 4173681 4175528 D function unknown role in lipid metabolism; fatty-acid-CoA ligase 4173681..4175528 Mycobacterium marinum M 6227660 YP_001851671.1 CDS MMAR_3390 NC_010612.1 4175571 4176503 D hydrolase 4175571..4176503 Mycobacterium marinum M 6227661 YP_001851672.1 CDS MMAR_3391 NC_010612.1 4176762 4178063 D hypothetical protein 4176762..4178063 Mycobacterium marinum M 6227662 YP_001851673.1 CDS MMAR_3392 NC_010612.1 4178221 4178733 D hypothetical protein 4178221..4178733 Mycobacterium marinum M 6227663 YP_001851674.1 CDS MMAR_3393 NC_010612.1 4178898 4179551 D methyltransferase 4178898..4179551 Mycobacterium marinum M 6227664 YP_001851675.1 CDS MMAR_3394 NC_010612.1 4179781 4181016 D function unknown; probably involved in cellular metabolism; hypothetical protein 4179781..4181016 Mycobacterium marinum M 6227665 YP_001851676.1 CDS MMAR_3395 NC_010612.1 4181044 4181703 D methyltransferase (methylase) 4181044..4181703 Mycobacterium marinum M 6227666 YP_001851677.1 CDS MMAR_3396 NC_010612.1 4181725 4182126 R hypothetical protein complement(4181725..4182126) Mycobacterium marinum M 6227667 YP_001851678.1 CDS MMAR_3397 NC_010612.1 4182222 4182818 D putative regulatory protein 4182222..4182818 Mycobacterium marinum M 6227668 YP_001851679.1 CDS MMAR_3398 NC_010612.1 4182921 4184789 D involved in signal transduction (via phosphorylation). thought to regulate phosphate transport. can phosphorylate the peptide substrate myelin basic protein (MBP) at serine and threonine residues. can be autophosphorylated on threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 4182921..4184789 Mycobacterium marinum M 6227669 YP_001851680.1 CDS MMAR_3399 NC_010612.1 4184882 4186258 R function unknown, possibly involved in cell wall biosynthesis. contains a putative beta-lactamase domain; hypothetical protein complement(4184882..4186258) Mycobacterium marinum M 6227670 YP_001851681.1 CDS MMAR_3400 NC_010612.1 4187433 4189922 D PE-PGRS family protein 4187433..4189922 Mycobacterium marinum M 6227671 YP_001851682.1 CDS MMAR_3401 NC_010612.1 4190040 4190795 D metabolism of malonate; maleate cis-trans isomerase 4190040..4190795 Mycobacterium marinum M 6227672 YP_001851683.1 CDS MMAR_3402 NC_010612.1 4190882 4192330 R function unknown; member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins; PE-PGRS family protein complement(4190882..4192330) Mycobacterium marinum M 6227673 YP_001851684.1 CDS MMAR_3403 NC_010612.1 4192705 4194105 D hypothetical protein 4192705..4194105 Mycobacterium marinum M 6227674 YP_001851685.1 CDS MMAR_3405 NC_010612.1 4194345 4199147 D function unknown; contains a N-term serine/threonine protein kinases, catalytic domain and two C-term WD40 domains. WD40 domains are found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the wd dipeptide at its c-terminus and is 40 residues long, hence the name WD40; putative regulatory protein 4194345..4199147 Mycobacterium marinum M 6227675 YP_001851686.1 CDS MMAR_3406 NC_010612.1 4199425 4200816 R hypothetical protein complement(4199425..4200816) Mycobacterium marinum M 6227676 YP_001851687.1 CDS gltD_1 NC_010612.1 4200926 4202611 D unknown function; putative glutamate synthase (NADPH) small subunit 4200926..4202611 Mycobacterium marinum M 6227677 YP_001851688.1 CDS MMAR_3408 NC_010612.1 4202608 4206189 D function unknown; probably involved in cellular metabolism; pyruvate ferredoxin/flavodoxin oxidoreductase family protein 4202608..4206189 Mycobacterium marinum M 6227678 YP_001851689.1 CDS MMAR_3409 NC_010612.1 4206189 4207199 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 4206189..4207199 Mycobacterium marinum M 6227679 YP_001851690.1 CDS MMAR_3410 NC_010612.1 4207227 4209632 D role in pyruvate metabolism. reaction: ATP + pyruvate + H(2)O <=> AMP + phosphoenolpyruvate + phosphate; pyruvate dikinase 4207227..4209632 Mycobacterium marinum M 6227680 YP_001851691.1 CDS pfkA_1 NC_010612.1 4209643 4210776 R involved in glycolysis; converts sugar-1-P to sugar- 1,6-P [catalytic activity: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate]; 6-phosphofructokinase complement(4209643..4210776) Mycobacterium marinum M 6227681 YP_001851692.1 CDS MMAR_3412 NC_010612.1 4210872 4211396 R hypothetical protein complement(4210872..4211396) Mycobacterium marinum M 6227682 YP_001851693.1 CDS MMAR_3413 NC_010612.1 4211498 4212883 D function unknown; probably involved in cellular metabolism; oxidoreductase 4211498..4212883 Mycobacterium marinum M 6227683 YP_001851694.1 CDS MMAR_3414 NC_010612.1 4212946 4213455 R hypothetical protein complement(4212946..4213455) Mycobacterium marinum M 6227684 YP_001851695.1 CDS pitB NC_010612.1 4214400 4216019 D involved in phosphate transport; phosphate-transport permease PitB 4214400..4216019 Mycobacterium marinum M 6227685 YP_001851696.1 CDS nirA NC_010612.1 4216439 4218106 D generates nitrite from ammonia using oxidized ferredoxin [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin]. the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur- containing amino acids and cofactors; ferredoxin-dependent nitrite/sulfite reductase NirA 4216439..4218106 Mycobacterium marinum M 6227686 YP_001851697.1 CDS cysH_1 NC_010612.1 4218136 4218870 D catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 4218136..4218870 Mycobacterium marinum M 6227687 YP_001851698.1 CDS MMAR_3418 NC_010612.1 4218867 4219586 D hypothetical protein 4218867..4219586 Mycobacterium marinum M 6227688 YP_001851699.1 CDS MMAR_3419 NC_010612.1 4219607 4220545 R LysR family transcriptional regulator complement(4219607..4220545) Mycobacterium marinum M 6227689 YP_001851700.1 CDS fprA NC_010612.1 4220632 4221996 D generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprA 4220632..4221996 Mycobacterium marinum M 6227690 YP_001851701.1 CDS fdxC_1 NC_010612.1 4222019 4222345 D ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxC 4222019..4222345 Mycobacterium marinum M 6227691 YP_001851702.1 CDS MMAR_3422 NC_010612.1 4222810 4223601 D hypothetical protein 4222810..4223601 Mycobacterium marinum M 6227692 YP_001851703.1 CDS MMAR_3423 NC_010612.1 4224055 4224648 R function unknown. possibly involved in transcriptional mechanism; putative transcriptional regulatory protein complement(4224055..4224648) Mycobacterium marinum M 6227693 YP_001851704.1 CDS MMAR_3424 NC_010612.1 4224833 4226197 R PE-PGRS family protein complement(4224833..4226197) Mycobacterium marinum M 6227694 YP_001851705.1 CDS MMAR_3425 NC_010612.1 4226483 4227715 D hypothetical protein 4226483..4227715 Mycobacterium marinum M 6227695 YP_001851706.1 CDS MMAR_3426 NC_010612.1 4227724 4228542 R function unknown; contains putative acyltransferase domain; hypothetical protein complement(4227724..4228542) Mycobacterium marinum M 6227696 YP_001851707.1 CDS MMAR_3427 NC_010612.1 4228833 4230482 R PE family protein complement(4228833..4230482) Mycobacterium marinum M 6227697 YP_001851708.1 CDS MMAR_3428 NC_010612.1 4230917 4231288 R function unknown but contains zinc binding domain found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone; hypothetical protein complement(4230917..4231288) Mycobacterium marinum M 6227698 YP_001851709.1 CDS lipM NC_010612.1 4231408 4232670 D hydrolysis of lipids (bound ester); membrane-bound esterase LipM 4231408..4232670 Mycobacterium marinum M 6227699 YP_001851710.1 CDS MMAR_3430 NC_010612.1 4232667 4233668 D hypothetical protein 4232667..4233668 Mycobacterium marinum M 6227700 YP_001851711.1 CDS MMAR_3431 NC_010612.1 4233857 4235197 D hypothetical protein 4233857..4235197 Mycobacterium marinum M 6227701 YP_001851712.1 CDS MMAR_3432 NC_010612.1 4235208 4236179 R transposition of of ISMyma04; transposase for ISMyma04 complement(4235208..4236179) Mycobacterium marinum M 6227702 YP_001851713.1 CDS MMAR_3433 NC_010612.1 4236369 4237517 D function unknown, probably involved in cellular metabolism; oxidoreductase 4236369..4237517 Mycobacterium marinum M 6227703 YP_001851714.1 CDS MMAR_3434 NC_010612.1 4237523 4238215 R hypothetical protein complement(4237523..4238215) Mycobacterium marinum M 6227704 YP_001851715.1 CDS MMAR_3435 NC_010612.1 4238360 4238800 R hypothetical protein complement(4238360..4238800) Mycobacterium marinum M 6227705 YP_001851716.1 CDS MMAR_3436 NC_010612.1 4239246 4240394 D hypothetical protein 4239246..4240394 Mycobacterium marinum M 6227706 YP_001851717.1 CDS yjcE NC_010612.1 4240490 4242082 D possibly involved in transport of Na+/H+ across the membrane; integral membrane transport protein YjcE 4240490..4242082 Mycobacterium marinum M 6227707 YP_001851718.1 CDS MMAR_3438 NC_010612.1 4242145 4242795 D involved in transcriptional mechanism; TetR family transcriptional regulator 4242145..4242795 Mycobacterium marinum M 6227708 YP_001851719.1 CDS MMAR_3439 NC_010612.1 4242788 4244314 D function unknown but contains identity with hydroxylase domain; hydroxylase 4242788..4244314 Mycobacterium marinum M 6227709 YP_001851720.1 CDS MMAR_3440 NC_010612.1 4244398 4245264 D function unknown but contains oxidoreductase domain; hypothetical protein 4244398..4245264 Mycobacterium marinum M 6227710 YP_001851721.1 CDS MMAR_3441 NC_010612.1 4245261 4245995 D hypothetical protein 4245261..4245995 Mycobacterium marinum M 6227711 YP_001851722.1 CDS MMAR_3442 NC_010612.1 4245989 4246327 R hypothetical protein complement(4245989..4246327) Mycobacterium marinum M 6227712 YP_001851723.1 CDS MMAR_3443 NC_010612.1 4247252 4248427 D PPE family protein 4247252..4248427 Mycobacterium marinum M 6227713 YP_001851724.1 CDS MMAR_3444 NC_010612.1 4248742 4249917 D PPE family protein 4248742..4249917 Mycobacterium marinum M 6227714 YP_001851725.1 CDS cdh NC_010612.1 4249993 4250787 R involved in phospholipid biosynthesis [catalytic activity: CDP-diacylglycerol + H(2)O = CMP + phosphatidate]; CDP-diacylglycerol pyrophosphatase complement(4249993..4250787) Mycobacterium marinum M 6227715 YP_001851726.1 CDS MMAR_3446 NC_010612.1 4250998 4251597 R hypothetical protein complement(4250998..4251597) Mycobacterium marinum M 6227716 YP_001851727.1 CDS MMAR_3447 NC_010612.1 4251594 4252094 R hypothetical protein complement(4251594..4252094) Mycobacterium marinum M 6227717 YP_001851728.1 CDS MMAR_3448 NC_010612.1 4252100 4253434 D hypothetical protein 4252100..4253434 Mycobacterium marinum M 6227718 YP_001851729.1 CDS MMAR_3449 NC_010612.1 4253481 4254482 D hydrolase 4253481..4254482 Mycobacterium marinum M 6227719 YP_001851730.1 CDS MMAR_3450 NC_010612.1 4254554 4254853 R hypothetical protein complement(4254554..4254853) Mycobacterium marinum M 6227720 YP_001851731.1 CDS MMAR_3451 NC_010612.1 4255276 4256142 D hypothetical protein 4255276..4256142 Mycobacterium marinum M 6227721 YP_001851732.1 CDS MMAR_3452 NC_010612.1 4256405 4257484 D hypothetical protein 4256405..4257484 Mycobacterium marinum M 6227722 YP_001851733.1 CDS MMAR_3453 NC_010612.1 4257552 4258751 D aminotransferase 4257552..4258751 Mycobacterium marinum M 6227723 YP_001851734.1 CDS MMAR_3454 NC_010612.1 4258755 4259300 R putative regulatory protein complement(4258755..4259300) Mycobacterium marinum M 6227724 YP_001851735.1 CDS MMAR_3455 NC_010612.1 4259409 4260281 D hypothetical protein 4259409..4260281 Mycobacterium marinum M 6227725 YP_001851736.1 CDS cysQ_1 NC_010612.1 4260300 4261028 R could help control the pool of 3'-PHOSPHOADENOSIDE 5'-phosphosulfate, or its use in sulfite synthesis (by similarity); monophosphatase CysQ complement(4260300..4261028) Mycobacterium marinum M 6227726 YP_001851737.1 CDS MMAR_3457 NC_010612.1 4261130 4262308 R hypothetical protein complement(4261130..4262308) Mycobacterium marinum M 6227727 YP_001851738.1 CDS MMAR_3461 NC_010612.1 4263984 4265408 R hypothetical protein complement(4263984..4265408) Mycobacterium marinum M 6227731 YP_001851739.1 CDS MMAR_3464 NC_010612.1 4267703 4267882 D potential pseudogene; transposase 4267703..4267882 Mycobacterium marinum M 6227734 YP_001851740.1 CDS MMAR_3465 NC_010612.1 4268538 4269680 R PPE family protein complement(4268538..4269680) Mycobacterium marinum M 6227735 YP_001851741.1 CDS MMAR_3466 NC_010612.1 4270650 4271339 D PPE family protein 4270650..4271339 Mycobacterium marinum M 6227736 YP_001851742.1 CDS MMAR_3467 NC_010612.1 4271575 4273302 R PE family protein complement(4271575..4273302) Mycobacterium marinum M 6227737 YP_001851743.1 CDS MMAR_3468 NC_010612.1 4273856 4274392 D hypothetical protein 4273856..4274392 Mycobacterium marinum M 6227738 YP_001851744.1 CDS MMAR_3470 NC_010612.1 4275073 4275858 R short chain membrane-associated dehydrogenase complement(4275073..4275858) Mycobacterium marinum M 6227740 YP_001851745.1 CDS MMAR_3471 NC_010612.1 4275868 4276302 R hypothetical protein complement(4275868..4276302) Mycobacterium marinum M 6227741 YP_001851746.1 CDS MMAR_3472 NC_010612.1 4276737 4277630 D may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide]; haloalkane dehalogenase 4276737..4277630 Mycobacterium marinum M 6227742 YP_001851747.1 CDS MMAR_3473 NC_010612.1 4277637 4278530 R initiates the elongation in type II fatty acid synthase systems. elongation of fatty acids in the type II systems occurs by claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA; ketoacyl-acyl carrier protein synthase III complement(4277637..4278530) Mycobacterium marinum M 6227743 YP_001851748.1 CDS MMAR_3474 NC_010612.1 4278514 4279614 R initiates the elongation in type II fatty acid synthase systems. elongation of fatty acids in the type II systems occurs by claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA; ketoacyl-acyl carrier protein synthase III complement(4278514..4279614) Mycobacterium marinum M 6227744 YP_001851749.1 CDS MMAR_3475 NC_010612.1 4279643 4280632 R hypothetical protein complement(4279643..4280632) Mycobacterium marinum M 6227745 YP_001851750.1 CDS MMAR_3476 NC_010612.1 4280736 4282184 R hypothetical protein complement(4280736..4282184) Mycobacterium marinum M 6227746 YP_001851751.1 CDS MMAR_3477 NC_010612.1 4282316 4283212 R function unknown; contains universal stress protein UspA domain - possible nucleotide-binding protein invloved in signal transduction mechanism; hypothetical protein complement(4282316..4283212) Mycobacterium marinum M 6227747 YP_001851752.1 CDS MMAR_3478 NC_010612.1 4283515 4284330 D function unknown. contains universal stress protein UspA domain - possible nucleotide-binding protein involved in signal transduction mechanisms; hypothetical protein 4283515..4284330 Mycobacterium marinum M 6227748 YP_001851753.1 CDS MMAR_3479 NC_010612.1 4284352 4286001 R sensor part of a two-component regulatory system; two-component sensor histidine kinase complement(4284352..4286001) Mycobacterium marinum M 6227749 YP_001851754.1 CDS MMAR_3480 NC_010612.1 4286242 4286895 R regulator part of a two-component regulatory system; two-component transcriptional regulatory protein complement(4286242..4286895) Mycobacterium marinum M 6227750 YP_001851755.1 CDS MMAR_3481 NC_010612.1 4287104 4287868 R function unknown. could play a role in in the phosphorelay of the two-component regulatory system; hypothetical protein complement(4287104..4287868) Mycobacterium marinum M 6227751 YP_001851756.1 CDS pfkB_1 NC_010612.1 4288010 4288981 R phosphofructokinase and related sugar kinases play an important role in the predominant pathway for fructose utilisation; phosphofructokinase, PfkB complement(4288010..4288981) Mycobacterium marinum M 6227752 YP_001851757.1 CDS MMAR_3483 NC_010612.1 4289010 4291052 R function unknown but contains N-term phosphoribosyltransferase domain and C-term eythromycin esterase; hypothetical protein complement(4289010..4291052) Mycobacterium marinum M 6227753 YP_001851758.1 CDS hspX_1 NC_010612.1 4291071 4291502 R thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR; heat shock protein HspX complement(4291071..4291502) Mycobacterium marinum M 6227754 YP_001851759.1 CDS MMAR_3485 NC_010612.1 4291698 4292024 R hypothetical protein complement(4291698..4292024) Mycobacterium marinum M 6227755 YP_001851760.1 CDS MMAR_3486 NC_010612.1 4292151 4292423 R hypothetical protein complement(4292151..4292423) Mycobacterium marinum M 6227756 YP_001851761.1 CDS MMAR_3487 NC_010612.1 4292633 4293613 R hypothetical protein complement(4292633..4293613) Mycobacterium marinum M 6227757 YP_001851762.1 CDS acs_1 NC_010612.1 4293932 4295731 D Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4293932..4295731 Mycobacterium marinum M 6227758 YP_001851763.1 CDS MMAR_3489 NC_010612.1 4295731 4296735 D involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (alpha subunit) 4295731..4296735 Mycobacterium marinum M 6227759 YP_001851764.1 CDS MMAR_3490 NC_010612.1 4296732 4297709 D involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (beta subunit) 4296732..4297709 Mycobacterium marinum M 6227760 YP_001851765.1 CDS MMAR_3491 NC_010612.1 4297706 4298947 D involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2; branched-chain alpha-keto acid dehydrogenase subunit E2 4297706..4298947 Mycobacterium marinum M 6227761 YP_001851766.1 CDS MMAR_3492 NC_010612.1 4298955 4299212 D function unknown; may act as an acyl carrier protein; hypothetical protein 4298955..4299212 Mycobacterium marinum M 6227762 YP_001851767.1 CDS MMAR_3493 NC_010612.1 4299314 4299733 D hypothetical protein 4299314..4299733 Mycobacterium marinum M 6227763 YP_001851768.1 CDS MMAR_3494 NC_010612.1 4299906 4301507 D function unknown; PE-PGRS family protein 4299906..4301507 Mycobacterium marinum M 6227764 YP_001851769.1 CDS MMAR_3495 NC_010612.1 4301767 4302186 D hypothetical protein 4301767..4302186 Mycobacterium marinum M 6227765 YP_001851770.1 CDS MMAR_3496 NC_010612.1 4302197 4302670 R function unknown: homology to ,Fe-hydrogenase maturation factor; hypothetical protein complement(4302197..4302670) Mycobacterium marinum M 6227766 YP_001851771.1 CDS MMAR_3497 NC_010612.1 4302667 4303959 R function unknown role in energy production and conversion; coenzyme F420-reducing hydrogenase subunit alpha complement(4302667..4303959) Mycobacterium marinum M 6227767 YP_001851772.1 CDS MMAR_3498 NC_010612.1 4303959 4304714 R coenzyme F420-reducing hydrogenase subunit gamma complement(4303959..4304714) Mycobacterium marinum M 6227768 YP_001851773.1 CDS MMAR_3499 NC_010612.1 4304715 4305572 R function unknown; involved in electron transfer; flavodoxin oxidoreductase complement(4304715..4305572) Mycobacterium marinum M 6227769 YP_001851774.1 CDS MMAR_3500 NC_010612.1 4305565 4306695 R electron transfer; ferredoxin complement(4305565..4306695) Mycobacterium marinum M 6227770 YP_001851775.1 CDS MMAR_3501 NC_010612.1 4306787 4307368 R hypothetical protein complement(4306787..4307368) Mycobacterium marinum M 6227771 YP_001851776.1 CDS MMAR_3502 NC_010612.1 4307430 4308431 R hypothetical protein complement(4307430..4308431) Mycobacterium marinum M 6227772 YP_001851777.1 CDS MMAR_3503 NC_010612.1 4308580 4310913 R metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase complement(4308580..4310913) Mycobacterium marinum M 6227773 YP_001851778.1 CDS MMAR_3504 NC_010612.1 4311086 4311457 R hypothetical protein complement(4311086..4311457) Mycobacterium marinum M 6227774 YP_001851779.1 CDS MMAR_3505 NC_010612.1 4311592 4312929 D function unknown; probably involved in cellular metabolism; hydrolase 4311592..4312929 Mycobacterium marinum M 6227775 YP_001851780.1 CDS MMAR_3506 NC_010612.1 4312975 4313838 R hypothetical protein complement(4312975..4313838) Mycobacterium marinum M 6227776 YP_001851781.1 CDS MMAR_3507 NC_010612.1 4313967 4314866 D involved in transcriptional mechanism; IclR family transcriptional regulator 4313967..4314866 Mycobacterium marinum M 6227777 YP_001851782.1 CDS MMAR_3508 NC_010612.1 4315033 4315539 D hypothetical protein 4315033..4315539 Mycobacterium marinum M 6227778 YP_001851783.1 CDS MMAR_3509 NC_010612.1 4315576 4316289 R short-chain alcohol dehydrogenase complement(4315576..4316289) Mycobacterium marinum M 6227779 YP_001851784.1 CDS echA8_5 NC_010612.1 4316466 4317242 D oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_5 4316466..4317242 Mycobacterium marinum M 6227780 YP_001851785.1 CDS MMAR_3511 NC_010612.1 4317227 4318393 D acyl-CoA dehydrogenase 4317227..4318393 Mycobacterium marinum M 6227781 YP_001851786.1 CDS MMAR_3512 NC_010612.1 4318390 4319418 D acyl-CoA dehydrogenase 4318390..4319418 Mycobacterium marinum M 6227782 YP_001851787.1 CDS MMAR_3513 NC_010612.1 4319432 4320247 R cellular metabolism; oxidoreductase complement(4319432..4320247) Mycobacterium marinum M 6227783 YP_001851788.1 CDS MMAR_3514 NC_010612.1 4320298 4321074 R function unknown, probably involved in cellular metabolism, possibly electron transfer; oxidoreductase complement(4320298..4321074) Mycobacterium marinum M 6227784 YP_001851789.1 CDS treX_1 NC_010612.1 4321262 4323406 R possibly involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); maltooligosyltrehalose synthase TreX complement(4321262..4323406) Mycobacterium marinum M 6227785 YP_001851790.1 CDS alkB_1 NC_010612.1 4323616 4324836 D thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O]; transmembrane alkane 1-monooxygenase AlkB 4323616..4324836 Mycobacterium marinum M 6227786 YP_001851791.1 CDS rubA_1 NC_010612.1 4324833 4325003 D involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase; rubredoxin RubA 4324833..4325003 Mycobacterium marinum M 6227787 YP_001851792.1 CDS rubB_1 NC_010612.1 4325005 4325190 D involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase; rubredoxin RubB 4325005..4325190 Mycobacterium marinum M 6227788 YP_001851793.1 CDS MMAR_3519 NC_010612.1 4325401 4326039 D probably involved in a transcriptional mechanism; TetR family transcriptional regulator 4325401..4326039 Mycobacterium marinum M 6227789 YP_001851794.1 CDS MMAR_3520 NC_010612.1 4326156 4327127 D hypothetical protein 4326156..4327127 Mycobacterium marinum M 6227790 YP_001851795.1 CDS htpG NC_010612.1 4327128 4329074 R molecular chaperone; heat shock protein 90 complement(4327128..4329074) Mycobacterium marinum M 6227791 YP_001851796.1 CDS MMAR_3522 NC_010612.1 4329202 4331913 D involved in transcriptional mechanism; LuxR family transcriptional regulator 4329202..4331913 Mycobacterium marinum M 6227792 YP_001851797.1 CDS MMAR_3523 NC_010612.1 4331941 4332723 R hypothetical protein complement(4331941..4332723) Mycobacterium marinum M 6227793 YP_001851798.1 CDS MMAR_3524 NC_010612.1 4332888 4334096 D hypothetical protein 4332888..4334096 Mycobacterium marinum M 6227794 YP_001851799.1 CDS MMAR_3525 NC_010612.1 4334121 4334870 R function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis; methylase complement(4334121..4334870) Mycobacterium marinum M 6227795 YP_001851800.1 CDS MMAR_3526 NC_010612.1 4335037 4336086 D function unknown but contains metal-dependant hydrolase domain identity; hypothetical protein 4335037..4336086 Mycobacterium marinum M 6227796 YP_001851801.1 CDS MMAR_3527 NC_010612.1 4336116 4336409 R hypothetical protein complement(4336116..4336409) Mycobacterium marinum M 6227797 YP_001851802.1 CDS MMAR_3528 NC_010612.1 4336543 4337091 R hypothetical protein complement(4336543..4337091) Mycobacterium marinum M 6227798 YP_001851803.1 CDS MMAR_3529 NC_010612.1 4337253 4338263 D function unknown; probably involved in cellular metabolism; dehydrogenase 4337253..4338263 Mycobacterium marinum M 6227799 YP_001851804.1 CDS MMAR_3530 NC_010612.1 4338315 4338743 R hypothetical protein complement(4338315..4338743) Mycobacterium marinum M 6227800 YP_001851805.1 CDS MMAR_3533 NC_010612.1 4340680 4341315 R methyltransferase (methylase) complement(4340680..4341315) Mycobacterium marinum M 6227803 YP_001851806.1 CDS MMAR_3534 NC_010612.1 4341312 4342244 R function unknown but high domain identity with O- Methyltransferases involved in polyketide biosynthesis; O-methyltransferase complement(4341312..4342244) Mycobacterium marinum M 6227804 YP_001851807.1 CDS MMAR_3535 NC_010612.1 4342358 4342774 D hypothetical protein 4342358..4342774 Mycobacterium marinum M 6227805 YP_001851808.1 CDS MMAR_3536 NC_010612.1 4342854 4343696 D function unknown, but high domain identity with epimerases and phenazine biosynthesis-like protein, PhzC/PhzF which is involved in dimerisation of two 2,3- dihydro-3-oxo-anthranilic acid molecules to create Pca by P. fluorescens; hypothetical protein 4342854..4343696 Mycobacterium marinum M 6227806 YP_001851809.1 CDS MMAR_3537 NC_010612.1 4343930 4345261 R hypothetical protein complement(4343930..4345261) Mycobacterium marinum M 6227807 YP_001851810.1 CDS MMAR_3538 NC_010612.1 4345254 4347428 R hypothetical protein complement(4345254..4347428) Mycobacterium marinum M 6227808 YP_001851811.1 CDS MMAR_3539 NC_010612.1 4347509 4348291 D function unknown but has ribonuclease I domain identity; hypothetical protein 4347509..4348291 Mycobacterium marinum M 6227809 YP_001851812.1 CDS MMAR_3540 NC_010612.1 4348831 4349457 D hypothetical protein 4348831..4349457 Mycobacterium marinum M 6227810 YP_001851813.1 CDS MMAR_3541 NC_010612.1 4349511 4350230 D conserved membrane protein of unknown function. similar to proteins from many organisms containing Cdd COG0398; uncharacterized conserved protein [function unknown]; hypothetical protein 4349511..4350230 Mycobacterium marinum M 6227811 YP_001851814.1 CDS MMAR_3542 NC_010612.1 4350333 4351463 D function unknown but domain identity with mechanosensitive ion channels; hypothetical protein 4350333..4351463 Mycobacterium marinum M 6227812 YP_001851815.1 CDS MMAR_3543 NC_010612.1 4351515 4354466 R function unknown but contains multiple functional domains including vWA domain (von willebrand factor (vWF) type a domain; found in extracellular proteins, like integrins, and mediates adhesion. also contains a vault protein inter-alpha-trypsin domain; hypothetical protein complement(4351515..4354466) Mycobacterium marinum M 6227813 YP_001851816.1 CDS MMAR_3544 NC_010612.1 4354531 4355313 D hypothetical protein 4354531..4355313 Mycobacterium marinum M 6227814 YP_001851817.1 CDS embR_1 NC_010612.1 4355362 4356501 D involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB; transcriptional regulatory protein EmbR 4355362..4356501 Mycobacterium marinum M 6227815 YP_001851818.1 CDS MMAR_3546 NC_010612.1 4356585 4358570 R PPE family protein complement(4356585..4358570) Mycobacterium marinum M 6227816 YP_001851819.1 CDS MMAR_3547 NC_010612.1 4359376 4362492 D involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]. N-term resembles PknK from MTB; serine/threonine-protein kinase transcriptional regulatory protein 4359376..4362492 Mycobacterium marinum M 6227817 YP_001851820.1 CDS MMAR_3548 NC_010612.1 4363068 4363862 D hypothetical protein 4363068..4363862 Mycobacterium marinum M 6227818 YP_001851821.1 CDS MMAR_3549 NC_010612.1 4364261 4366438 D function unknown but contains glutamine synthetase catalytic domain; hypothetical protein 4364261..4366438 Mycobacterium marinum M 6227819 YP_001851822.1 CDS MMAR_3550 NC_010612.1 4366707 4367987 R PE-PGRS family protein complement(4366707..4367987) Mycobacterium marinum M 6227820 YP_001851823.1 CDS MMAR_3551 NC_010612.1 4368447 4369025 D proline, glycine, valine-rich secreted protein 4368447..4369025 Mycobacterium marinum M 6227821 YP_001851824.1 CDS MMAR_3552 NC_010612.1 4369026 4369964 R hypothetical protein complement(4369026..4369964) Mycobacterium marinum M 6227822 YP_001851825.1 CDS MMAR_3553 NC_010612.1 4370312 4371070 D function unknown, probably involved in cellular metabolism; alanine rich hydrolase 4370312..4371070 Mycobacterium marinum M 6227823 YP_001851826.1 CDS MMAR_3554 NC_010612.1 4371087 4372862 R function unknown. possibly transporter involved in transport of undeterminated substrate (possibly cationic amino acids) across the membrane: so responsible for the translocation of the substrate across the membrane; hypothetical protein complement(4371087..4372862) Mycobacterium marinum M 6227824 YP_001851827.1 CDS MMAR_3555 NC_010612.1 4372946 4374163 R function unknown, high domain identity with saccharopine dehydrogenase. this family comprises three structural domains that can not be separated in the linear sequence. in some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate; saccharopine dehydrogenase complement(4372946..4374163) Mycobacterium marinum M 6227825 YP_001851828.1 CDS MMAR_3556 NC_010612.1 4374453 4375943 R catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase complement(4374453..4375943) Mycobacterium marinum M 6227826 YP_001851829.1 CDS MMAR_3557 NC_010612.1 4376065 4376580 D involved in transcriptional mechanism; Lrp/AsnC family transcriptional regulator 4376065..4376580 Mycobacterium marinum M 6227827 YP_001851830.1 CDS MMAR_3558 NC_010612.1 4376577 4377932 D function unknown, high domain identity with BioA, aminotransferase [coenzyme metabolism]; hypothetical protein 4376577..4377932 Mycobacterium marinum M 6227828 YP_001851831.1 CDS MMAR_3559 NC_010612.1 4378030 4378860 R function unknown - possible oxidoreducatse; hypothetical protein complement(4378030..4378860) Mycobacterium marinum M 6227829 YP_001851832.1 CDS MMAR_3560 NC_010612.1 4378965 4379531 R possibly involved in transcriptional mechanism; transcriptional regulatory protein complement(4378965..4379531) Mycobacterium marinum M 6227830 YP_001851833.1 CDS MMAR_3561 NC_010612.1 4379646 4380491 D function unknown, probably involved in cellular metabolism; short chain dehydrogenase 4379646..4380491 Mycobacterium marinum M 6227831 YP_001851834.1 CDS MMAR_3562 NC_010612.1 4380522 4380950 D hypothetical protein 4380522..4380950 Mycobacterium marinum M 6227832 YP_001851835.1 CDS MMAR_3563 NC_010612.1 4380947 4381375 R rifampin ADP-ribosyl transferase complement(4380947..4381375) Mycobacterium marinum M 6227833 YP_001851836.1 CDS qor_1 NC_010612.1 4381377 4382534 R catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone reductase, Qor complement(4381377..4382534) Mycobacterium marinum M 6227834 YP_001851837.1 CDS amiC_1 NC_010612.1 4382638 4384074 D hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidase 4382638..4384074 Mycobacterium marinum M 6227835 YP_001851838.1 CDS plcB NC_010612.1 4384117 4385682 R hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB complement(4384117..4385682) Mycobacterium marinum M 6227836 YP_001851839.1 CDS MMAR_3568 NC_010612.1 4386332 4387381 D hypothetical protein 4386332..4387381 Mycobacterium marinum M 6227837 YP_001851840.1 CDS MMAR_3569 NC_010612.1 4387565 4387840 R hypothetical protein complement(4387565..4387840) Mycobacterium marinum M 6227838 YP_001851841.1 CDS MMAR_3570 NC_010612.1 4388079 4390853 D PE-PGRS family protein 4388079..4390853 Mycobacterium marinum M 6227839 YP_001851842.1 CDS MMAR_3571 NC_010612.1 4390998 4391291 D hypothetical protein 4390998..4391291 Mycobacterium marinum M 6227840 YP_001851843.1 CDS MMAR_3572 NC_010612.1 4391295 4392200 D hypothetical protein 4391295..4392200 Mycobacterium marinum M 6227841 YP_001851844.1 CDS MMAR_3573 NC_010612.1 4392197 4393141 D hypothetical protein 4392197..4393141 Mycobacterium marinum M 6227842 YP_001851845.1 CDS MMAR_3574 NC_010612.1 4394055 4394789 R hypothetical protein complement(4394055..4394789) Mycobacterium marinum M 6227843 YP_001851846.1 CDS MMAR_3575 NC_010612.1 4395197 4396084 R function unknown; contains two OpuBC, periplasmic glycine betaine/choline-binding (LipO)protein domains of an ABC-type transport system (osmoprotectant binding protein); hypothetical protein complement(4395197..4396084) Mycobacterium marinum M 6227844 YP_001851847.1 CDS MMAR_3576 NC_010612.1 4396088 4396873 R function unknown; domain identity with lactoylglutathione lyase; hypothetical protein complement(4396088..4396873) Mycobacterium marinum M 6227845 YP_001851848.1 CDS MMAR_3577 NC_010612.1 4397066 4398097 R hypothetical protein complement(4397066..4398097) Mycobacterium marinum M 6227846 YP_001851849.1 CDS MMAR_3578 NC_010612.1 4399046 4400137 D PPE family protein 4399046..4400137 Mycobacterium marinum M 6227847 YP_001851850.1 CDS esxK NC_010612.1 4400260 4400547 D EsaT-6 like protein EsxK 4400260..4400547 Mycobacterium marinum M 6227848 YP_001851851.1 CDS esxN_6 NC_010612.1 4400665 4400949 D EsaT-6 like protein EsxN_6 4400665..4400949 Mycobacterium marinum M 6227849 YP_001851852.1 CDS MMAR_3581 NC_010612.1 4401186 4403237 D PE-PGRS family protein 4401186..4403237 Mycobacterium marinum M 6227850 YP_001851853.1 CDS MMAR_3582 NC_010612.1 4403573 4403839 D hypothetical protein 4403573..4403839 Mycobacterium marinum M 6227851 YP_001851854.1 CDS MMAR_3583 NC_010612.1 4404177 4404794 D hypothetical protein 4404177..4404794 Mycobacterium marinum M 6227852 YP_001851855.1 CDS MMAR_3584 NC_010612.1 4404924 4405448 D DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes; phage-related integrase 4404924..4405448 Mycobacterium marinum M 6227853 YP_001851856.1 CDS MMAR_3585 NC_010612.1 4405461 4405673 D phage-related integrase 4405461..4405673 Mycobacterium marinum M 6227854 YP_001851857.1 CDS MMAR_3586 NC_010612.1 4406071 4406700 D hypothetical protein 4406071..4406700 Mycobacterium marinum M 6227855 YP_001851858.1 CDS MMAR_3587 NC_010612.1 4406697 4407458 D hypothetical protein 4406697..4407458 Mycobacterium marinum M 6227856 YP_001851859.1 CDS MMAR_3588 NC_010612.1 4407496 4408092 D hypothetical protein 4407496..4408092 Mycobacterium marinum M 6227857 YP_001851860.1 CDS MMAR_3591 NC_010612.1 4409457 4409717 R hypothetical protein complement(4409457..4409717) Mycobacterium marinum M 6227860 YP_001851861.1 CDS MMAR_3592 NC_010612.1 4409714 4409872 R hypothetical protein complement(4409714..4409872) Mycobacterium marinum M 6227861 YP_001851862.1 CDS MMAR_3593 NC_010612.1 4410127 4410423 D hypothetical protein 4410127..4410423 Mycobacterium marinum M 6227862 YP_001851863.1 CDS MMAR_3594 NC_010612.1 4410875 4411483 D hypothetical protein 4410875..4411483 Mycobacterium marinum M 6227863 YP_001851864.1 CDS MMAR_3595 NC_010612.1 4411480 4412331 D hypothetical protein 4411480..4412331 Mycobacterium marinum M 6227864 YP_001851865.1 CDS MMAR_3596 NC_010612.1 4412684 4414411 D hypothetical protein 4412684..4414411 Mycobacterium marinum M 6227865 YP_001851866.1 CDS MMAR_3597 NC_010612.1 4414512 4416110 D may be part of a phage restriction modification system; ATP-dependent OLD family endonuclease 4414512..4416110 Mycobacterium marinum M 6227866 YP_001851867.1 CDS MMAR_3598 NC_010612.1 4416097 4417131 D may be involved in phage replication; helicase 4416097..4417131 Mycobacterium marinum M 6227867 YP_001851868.1 CDS MMAR_3599 NC_010612.1 4417219 4420227 R involved in chromosome structure and partitioning. essential for chromosome partition. part of phage replication machinery; chromosome partition ATPase protein complement(4417219..4420227) Mycobacterium marinum M 6227868 YP_001851869.1 CDS MMAR_3600 NC_010612.1 4420224 4421456 R part of phage replication machinery; DNA repair exonuclease complement(4420224..4421456) Mycobacterium marinum M 6227869 YP_001851870.1 CDS MMAR_3601 NC_010612.1 4421453 4423267 R function unknown; may have ATPase activity; hypothetical protein complement(4421453..4423267) Mycobacterium marinum M 6227870 YP_001851871.1 CDS MMAR_3602 NC_010612.1 4423281 4424261 R hypothetical protein complement(4423281..4424261) Mycobacterium marinum M 6227871 YP_001851872.1 CDS MMAR_3603 NC_010612.1 4424424 4424756 D part of a plasmid or prophage maintenance system for killing segregants. weak identity with a putative killer suppression protein HigA from Methylococcus capsulatus str. Bath; killer suppression protein 4424424..4424756 Mycobacterium marinum M 6227872 YP_001851873.1 CDS MMAR_3604 NC_010612.1 4424778 4425872 D ensures cells expressing the corresponding protein toxin are not killed; plasmid maintenance system antidote protein 4424778..4425872 Mycobacterium marinum M 6227873 YP_001851874.1 CDS MMAR_3605 NC_010612.1 4426055 4428859 R probably involved in phage replication. may play a role in DNA helix relaxation; ATP-dependent exoDNAse complement(4426055..4428859) Mycobacterium marinum M 6227874 YP_001851875.1 CDS MMAR_3606 NC_010612.1 4429273 4429479 D hypothetical protein 4429273..4429479 Mycobacterium marinum M 6227875 YP_001851876.1 CDS MMAR_3607 NC_010612.1 4429513 4430775 D DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes; phage integrase 4429513..4430775 Mycobacterium marinum M 6227876 YP_001851877.1 CDS MMAR_3608 NC_010612.1 4431723 4432574 D hypothetical protein 4431723..4432574 Mycobacterium marinum M 6227878 YP_001851878.1 CDS mmpL4 NC_010612.1 4432844 4433185 D function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL4 4432844..4433185 Mycobacterium marinum M 6227879 YP_001851879.1 CDS MMAR_3610 NC_010612.1 4433559 4433993 D hypothetical protein 4433559..4433993 Mycobacterium marinum M 6227880 YP_001851880.1 CDS MMAR_3611 NC_010612.1 4434096 4434647 R hypothetical protein complement(4434096..4434647) Mycobacterium marinum M 6227881 YP_001851881.1 CDS MMAR_3612 NC_010612.1 4434864 4437476 D metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporter p-type ATPase a 4434864..4437476 Mycobacterium marinum M 6227882 YP_001851882.1 CDS MMAR_5561 NC_010612.1 4437473 4437775 R hypothetical protein complement(4437473..4437775) Mycobacterium marinum M 6227883 YP_001851883.1 CDS MMAR_3613 NC_010612.1 4437949 4438731 R hypothetical protein complement(4437949..4438731) Mycobacterium marinum M 6227884 YP_001851884.1 CDS MMAR_3614 NC_010612.1 4438728 4439582 R hypothetical protein complement(4438728..4439582) Mycobacterium marinum M 6227885 YP_001851885.1 CDS MMAR_3615 NC_010612.1 4439623 4440996 R hypothetical protein complement(4439623..4440996) Mycobacterium marinum M 6227886 YP_001851886.1 CDS MMAR_3616 NC_010612.1 4440993 4442510 R hypothetical protein complement(4440993..4442510) Mycobacterium marinum M 6227887 YP_001851887.1 CDS uspA NC_010612.1 4442545 4443417 D thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein ABC transporter UspA 4442545..4443417 Mycobacterium marinum M 6227888 YP_001851888.1 CDS uspB NC_010612.1 4443404 4444243 D thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein ABC transporter UspB 4443404..4444243 Mycobacterium marinum M 6227889 YP_001851889.1 CDS uspC NC_010612.1 4444240 4445568 D thought to be involved in active transport of sugar across the membrane (import); periplasmic sugar-binding lipoprotein UspC 4444240..4445568 Mycobacterium marinum M 6227890 YP_001851890.1 CDS MMAR_3620 NC_010612.1 4445599 4446471 R hypothetical protein complement(4445599..4446471) Mycobacterium marinum M 6227891 YP_001851891.1 CDS rocE NC_010612.1 4446468 4447937 R thought to be involved in transport of cationic amino acid (especially arginine and ornithine) across the membrane. responsible for the translocation of the substrate across the membrane; cationic amino acid transport integral membrane protein RocE complement(4446468..4447937) Mycobacterium marinum M 6227892 YP_001851892.1 CDS rocD NC_010612.1 4447967 4449211 R involved in arginine metabolism [catalytic activity: L-ornithine + a 2-OXO acid = L-glutamate 5- semialdehyde + an L-amino acid]; ornithine aminotransferase RocD1 and RocD2 complement(4447967..4449211) Mycobacterium marinum M 6227893 YP_001851893.1 CDS MMAR_3623 NC_010612.1 4449208 4450083 R hypothetical protein complement(4449208..4450083) Mycobacterium marinum M 6227894 YP_001851894.1 CDS MMAR_3624 NC_010612.1 4450207 4450659 D involved in transcriptional mechanism; AsnC family transcriptional regulator 4450207..4450659 Mycobacterium marinum M 6227895 YP_001851895.1 CDS MMAR_3625 NC_010612.1 4450656 4451516 R hypothetical protein complement(4450656..4451516) Mycobacterium marinum M 6227896 YP_001851896.1 CDS MMAR_3626 NC_010612.1 4451513 4453585 R probably involved in active transport accross the membrane. thought to be responsible for energy coupling to the transport system and the translocation of the substrate across the membrane; transmembrane ATP-binding protein ABC transorter complement(4451513..4453585) Mycobacterium marinum M 6227897 YP_001851897.1 CDS MMAR_3627 NC_010612.1 4453704 4454180 D hypothetical protein 4453704..4454180 Mycobacterium marinum M 6227898 YP_001851898.1 CDS MMAR_3628 NC_010612.1 4454347 4456866 D thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 4454347..4456866 Mycobacterium marinum M 6227899 YP_001851899.1 CDS MMAR_3629 NC_010612.1 4456839 4457999 R hypothetical protein complement(4456839..4457999) Mycobacterium marinum M 6227900 YP_001851900.1 CDS MMAR_3630 NC_010612.1 4457996 4458730 R membrane protein complement(4457996..4458730) Mycobacterium marinum M 6227901 YP_001851901.1 CDS MMAR_3631 NC_010612.1 4458856 4460799 D function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein; acyl-CoA dehydrogenase 4458856..4460799 Mycobacterium marinum M 6227902 YP_001851902.1 CDS MMAR_3632 NC_010612.1 4460906 4462546 R tryptophan halogenase catalyses the chlorination of tryptophan to form 7-chlorotryptophan. this is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. tryptophan halogenase is NADH-dependent; tryptophan halogenase complement(4460906..4462546) Mycobacterium marinum M 6227903 YP_001851903.1 CDS MMAR_5573 NC_010612.1 4462552 4462680 R hypothetical protein complement(4462552..4462680) Mycobacterium marinum M 6227904 YP_001851904.1 CDS MMAR_3633 NC_010612.1 4463193 4472699 D function unknown but contains 3 modules for the potential synthesis of a tripeptide; peptide synthetase Nrp (peptide synthase) 4463193..4472699 Mycobacterium marinum M 6227905 YP_001851905.1 CDS MMAR_3634 NC_010612.1 4472719 4473276 D function unknown; probably involved in cellular metabolism; oxidase 4472719..4473276 Mycobacterium marinum M 6227906 YP_001851906.1 CDS MMAR_3635 NC_010612.1 4473351 4474646 D probably involved in transport of undeterminated substrate (possibly cations Na/H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane; integral membrane ion antiporter 4473351..4474646 Mycobacterium marinum M 6227907 YP_001851907.1 CDS MMAR_3636 NC_010612.1 4474722 4475495 D function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis; methylase 4474722..4475495 Mycobacterium marinum M 6227908 YP_001851908.1 CDS narK1 NC_010612.1 4475790 4477313 R involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK1 complement(4475790..4477313) Mycobacterium marinum M 6227909 YP_001851909.1 CDS lppP NC_010612.1 4477537 4478040 R lipoprotein LppP complement(4477537..4478040) Mycobacterium marinum M 6227910 YP_001851910.1 CDS fdhF NC_010612.1 4478460 4482668 D decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [catalytic activity: formate + NAD(+) = CO(2) + NADH]; formate dehydrogenase H FdhF 4478460..4482668 Mycobacterium marinum M 6227911 YP_001851911.1 CDS MMAR_3640 NC_010612.1 4482993 4484921 D thought to play an essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'- cyclic AMP + pyrophosphate]; adenylate cyclase 4482993..4484921 Mycobacterium marinum M 6227912 YP_001851912.1 CDS MMAR_3641 NC_010612.1 4485827 4487188 D PPE family protein 4485827..4487188 Mycobacterium marinum M 6227913 YP_001851913.1 CDS MMAR_3642 NC_010612.1 4487502 4489058 R thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane; integral membrane transport protein complement(4487502..4489058) Mycobacterium marinum M 6227914 YP_001851914.1 CDS mez NC_010612.1 4489474 4491120 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 4489474..4491120 Mycobacterium marinum M 6227915 YP_001851915.1 CDS MMAR_3644 NC_010612.1 4491428 4491844 D hypothetical protein 4491428..4491844 Mycobacterium marinum M 6227916 YP_001851916.1 CDS cysK1 NC_010612.1 4491841 4492773 D involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L-cysteine + acetate]; cysteine synthase a CysK1 4491841..4492773 Mycobacterium marinum M 6227917 YP_001851917.1 CDS cysE NC_010612.1 4492770 4493462 D involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine]; serine acetyltransferase CysE 4492770..4493462 Mycobacterium marinum M 6227918 YP_001851918.1 CDS thiX NC_010612.1 4493473 4493901 D thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin ThiX 4493473..4493901 Mycobacterium marinum M 6227919 YP_001851919.1 CDS MMAR_3648 NC_010612.1 4493929 4494381 D function unknown, contains N-term signal peptide indicative of secreted protein; hypothetical protein 4493929..4494381 Mycobacterium marinum M 6227920 YP_001851920.1 CDS MMAR_3649 NC_010612.1 4494748 4494993 D hypothetical protein 4494748..4494993 Mycobacterium marinum M 6227922 YP_001851921.1 CDS dnaG NC_010612.1 4495008 4496978 R synthesizes RNA primers at the replication forks; DNA primase complement(4495008..4496978) Mycobacterium marinum M 6227923 YP_001851922.1 CDS dgt NC_010612.1 4497020 4498390 R dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein complement(4497020..4498390) Mycobacterium marinum M 6227924 YP_001851923.1 CDS MMAR_3652 NC_010612.1 4498441 4500429 D hypothetical protein 4498441..4500429 Mycobacterium marinum M 6227925 YP_001851924.1 CDS esxN_3 NC_010612.1 4500638 4500922 R EsaT-6 like protein EsxN_3 complement(4500638..4500922) Mycobacterium marinum M 6227926 YP_001851925.1 CDS esxP_2 NC_010612.1 4500985 4501281 R EsaT-6 like protein EsxP_2 complement(4500985..4501281) Mycobacterium marinum M 6227927 YP_001851926.1 CDS MMAR_3655 NC_010612.1 4501414 4501731 R hypothetical protein complement(4501414..4501731) Mycobacterium marinum M 6227928 YP_001851927.1 CDS plcB_5 NC_010612.1 4502018 4503568 R hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB complement(4502018..4503568) Mycobacterium marinum M 6227929 YP_001851928.1 CDS plcB_4 NC_010612.1 4503965 4505527 R hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB complement(4503965..4505527) Mycobacterium marinum M 6227930 YP_001851929.1 CDS MMAR_3658 NC_010612.1 4506113 4506901 D hypothetical protein 4506113..4506901 Mycobacterium marinum M 6227931 YP_001851930.1 CDS esxN_4 NC_010612.1 4507101 4507385 R EsaT-6 like protein EsxN_4 complement(4507101..4507385) Mycobacterium marinum M 6227932 YP_001851931.1 CDS esxP_3 NC_010612.1 4507400 4507696 R EsaT-6 like protein EsxP_3 complement(4507400..4507696) Mycobacterium marinum M 6227933 YP_001851932.1 CDS MMAR_3661 NC_010612.1 4507776 4508939 R PPE family protein complement(4507776..4508939) Mycobacterium marinum M 6227934 YP_001851933.1 CDS esxN_5 NC_010612.1 4509214 4509498 R EsaT-6 like protein EsxN_5 complement(4509214..4509498) Mycobacterium marinum M 6227935 YP_001851934.1 CDS esxP_4 NC_010612.1 4509513 4509809 R EsaT-6 like protein EsxP_4 complement(4509513..4509809) Mycobacterium marinum M 6227936 YP_001851935.1 CDS MMAR_3664 NC_010612.1 4509889 4511055 R PPE family protein complement(4509889..4511055) Mycobacterium marinum M 6227937 YP_001851936.1 CDS MMAR_3665 NC_010612.1 4511619 4513529 R PPE family protein complement(4511619..4513529) Mycobacterium marinum M 6227938 YP_001851937.1 CDS MMAR_3666 NC_010612.1 4513819 4515744 R PPE family protein complement(4513819..4515744) Mycobacterium marinum M 6227939 YP_001851938.1 CDS glyS NC_010612.1 4515981 4517372 R Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase complement(4515981..4517372) Mycobacterium marinum M 6227940 YP_001851939.1 CDS MMAR_3668 NC_010612.1 4517566 4517961 D involved in transcriptional mechanism; ArsR family transcriptional regulator 4517566..4517961 Mycobacterium marinum M 6227941 YP_001851940.1 CDS zur NC_010612.1 4517958 4518371 D acts as a global negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes; Zinc uptake regulation protein Zur 4517958..4518371 Mycobacterium marinum M 6227942 YP_001851941.1 CDS MMAR_3670 NC_010612.1 4518368 4518808 R hypothetical protein complement(4518368..4518808) Mycobacterium marinum M 6227943 YP_001851942.1 CDS MMAR_3671 NC_010612.1 4518808 4519698 R catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase complement(4518808..4519698) Mycobacterium marinum M 6227944 YP_001851943.1 CDS recO NC_010612.1 4519691 4520488 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(4519691..4520488) Mycobacterium marinum M 6227945 YP_001851944.1 CDS amiA2 NC_010612.1 4520550 4522049 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 4520550..4522049 Mycobacterium marinum M 6227946 YP_001851945.1 CDS era NC_010612.1 4522046 4522948 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(4522046..4522948) Mycobacterium marinum M 6227947 YP_001851946.1 CDS MMAR_3675 NC_010612.1 4522938 4523168 R hypothetical protein complement(4522938..4523168) Mycobacterium marinum M 6227948 YP_001851947.1 CDS MMAR_3676 NC_010612.1 4523137 4524459 R hypothetical protein complement(4523137..4524459) Mycobacterium marinum M 6227949 YP_001851948.1 CDS MMAR_3677 NC_010612.1 4524456 4524992 R putative metalloprotease complement(4524456..4524992) Mycobacterium marinum M 6227950 YP_001851949.1 CDS phoH1 NC_010612.1 4525011 4526069 R PhoH-like protein PhoH1 complement(4525011..4526069) Mycobacterium marinum M 6227951 YP_001851950.1 CDS MMAR_3679 NC_010612.1 4526137 4526835 R function unknown but contains tetracycline repressor-like C-terminal superfamily domain; putative regulatory protein complement(4526137..4526835) Mycobacterium marinum M 6227952 YP_001851951.1 CDS MMAR_3680 NC_010612.1 4526863 4527759 D function unknown but contains alpha/beta-hydrolase superfamily domain; hypothetical protein 4526863..4527759 Mycobacterium marinum M 6227953 YP_001851952.1 CDS MMAR_3681 NC_010612.1 4527847 4528386 D hypothetical protein 4527847..4528386 Mycobacterium marinum M 6227954 YP_001851953.1 CDS MMAR_3682 NC_010612.1 4528409 4529170 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(4528409..4529170) Mycobacterium marinum M 6227955 YP_001851954.1 CDS dnaJ2 NC_010612.1 4529199 4530335 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(4529199..4530335) Mycobacterium marinum M 6227956 YP_001851955.1 CDS hrcA NC_010612.1 4530410 4531441 R Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor complement(4530410..4531441) Mycobacterium marinum M 6227957 YP_001851956.1 CDS MMAR_3685 NC_010612.1 4531714 4532028 D hypothetical protein 4531714..4532028 Mycobacterium marinum M 6227958 YP_001851957.1 CDS MMAR_3686 NC_010612.1 4532123 4532722 D function unknown but contains identity with antioxidant defence protein Ahp; hypothetical protein 4532123..4532722 Mycobacterium marinum M 6227959 YP_001851958.1 CDS MMAR_3687 NC_010612.1 4532719 4533618 D the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. belongs to the sigma-70 factor family, ECF subfamily; alternative RNA polymerase sigma factor SigJ-like protein 4532719..4533618 Mycobacterium marinum M 6227960 YP_001851959.1 CDS cfp2 NC_010612.1 4533656 4534165 R function not known (putative secreted protein); may play a role in the development of protective immune responses; low molecular weight antigen Cfp2 complement(4533656..4534165) Mycobacterium marinum M 6227961 YP_001851960.1 CDS mbtB NC_010612.1 4534449 4537940 R involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this peptide synthase forms amide bound between the carboxylic acid of salicylate and the alpha-amino group of serine (serine/threonine ligation); phenyloxazoline synthase MbtB complement(4534449..4537940) Mycobacterium marinum M 6227962 YP_001851961.1 CDS mbtF NC_010612.1 4537976 4542514 R involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. activates amino acid residues that are incorporated into mycobactin (ligation); non-ribosomal peptide synthetase MbtF complement(4537976..4542514) Mycobacterium marinum M 6227963 YP_001851962.1 CDS mbtE NC_010612.1 4542511 4547523 R involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. probably activates the two lysine residues that are incorporated into mycobactin (lysine ligation); non-ribosomal peptide synthetase MbtE complement(4542511..4547523) Mycobacterium marinum M 6227964 YP_001851963.1 CDS MMAR_3692 NC_010612.1 4547798 4548403 D function unknown but contains acyl-CoA N- acetyltransferase superfamily domain; hypothetical protein 4547798..4548403 Mycobacterium marinum M 6227965 YP_001851964.1 CDS MMAR_3693 NC_010612.1 4548513 4549271 D may be required for the addition of the terminal aa in this Nrp operon; thioesterase 4548513..4549271 Mycobacterium marinum M 6227966 YP_001851965.1 CDS mbtC NC_010612.1 4549268 4550587 D involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; polyketide synthase MbtC 4549268..4550587 Mycobacterium marinum M 6227967 YP_001851966.1 CDS mbtD NC_010612.1 4550584 4553658 D involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; polyketide synthase MbtD 4550584..4553658 Mycobacterium marinum M 6227968 YP_001851967.1 CDS mbtH_1 NC_010612.1 4553663 4553878 R thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; hypothetical protein complement(4553663..4553878) Mycobacterium marinum M 6227969 YP_001851968.1 CDS mbtG NC_010612.1 4553859 4555268 R involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this hydroxylase is possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly [catalytic activity: L-lysine + O(2) = N6-hydroxy- L-lysine + H(2)O. no information can be found if this enzyme is NADPH dependent or independent]; lysine-N-oxygenase MbtG complement(4553859..4555268) Mycobacterium marinum M 6227970 YP_001851969.1 CDS mbtA NC_010612.1 4555360 4557012 D involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins (initiation step of mycobactin chain growth). activates the mycobactin ACP in two half-reactions: activates salicylic acid as acyladenylate (adenylation step) + transfers activated salicylate to the MbtA ACP as a thioester (arylation step); bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 4555360..4557012 Mycobacterium marinum M 6227971 YP_001851970.1 CDS mbtJ NC_010612.1 4557131 4558126 D involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly; acetyl hydrolase MbtJ 4557131..4558126 Mycobacterium marinum M 6227972 YP_001851971.1 CDS MMAR_3700 NC_010612.1 4558128 4558988 D short-chain membrane-associated dehydrogenase 4558128..4558988 Mycobacterium marinum M 6227973 YP_001851972.1 CDS MMAR_3701 NC_010612.1 4559020 4559940 D function unknown but contains ferritin/ribonucleotide reductase-like superfamily domain; putative reductase 4559020..4559940 Mycobacterium marinum M 6227974 YP_001851973.1 CDS MMAR_3702 NC_010612.1 4559937 4561448 D function unknown; involved in cellular metabolism; flavin-binding monooxygenase 4559937..4561448 Mycobacterium marinum M 6227975 YP_001851974.1 CDS MMAR_3703 NC_010612.1 4561445 4562407 D function unknown. possibly involved in transcriptional mechanism; putative transcriptional regulator 4561445..4562407 Mycobacterium marinum M 6227976 YP_001851975.1 CDS desA1_1 NC_010612.1 4562439 4563455 R catalyzes the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O]; acyl-[acyl-carrier protein] desaturase DesA1 complement(4562439..4563455) Mycobacterium marinum M 6227977 YP_001851976.1 CDS MMAR_3705 NC_010612.1 4563525 4564328 R hypothetical protein complement(4563525..4564328) Mycobacterium marinum M 6227978 YP_001851977.1 CDS mbtI NC_010612.1 4564529 4565887 R catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; salicylate synthase MbtI complement(4564529..4565887) Mycobacterium marinum M 6227979 YP_001851978.1 CDS MMAR_3707 NC_010612.1 4566280 4566489 D hypothetical protein 4566280..4566489 Mycobacterium marinum M 6227980 YP_001851979.1 CDS MMAR_3708 NC_010612.1 4566779 4568014 D membrane permease 4566779..4568014 Mycobacterium marinum M 6227981 YP_001851980.1 CDS hemN NC_010612.1 4568026 4569198 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(4568026..4569198) Mycobacterium marinum M 6227982 YP_001851981.1 CDS nirA_2 NC_010612.1 4569636 4571303 D generates nitrite from ammonia using oxidized ferredoxin [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin]. can also act as a sulphite reductase. the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur-containing amino acids and cofactors. this appears to be the only intact nitrite reductase in M. ulcerans; ferredoxin-dependent nitrite/sulfite reductase NirA 4569636..4571303 Mycobacterium marinum M 6227983 YP_001851982.1 CDS cysH NC_010612.1 4571300 4572049 D catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 4571300..4572049 Mycobacterium marinum M 6227984 YP_001851983.1 CDS MMAR_3712 NC_010612.1 4572046 4572759 D function unknown but contains a chelatase superfamily domain. given the presence of other heme- associated CDS in this region and the presence of a chelatase superfamily domain, this CDS may encode a ferrochelatase, catalyzing the last step in HemE biosynthesis; hypothetical protein 4572046..4572759 Mycobacterium marinum M 6227985 YP_001851984.1 CDS ggtB NC_010612.1 4572774 4574714 D plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione [catalytic activity: 5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid]; gamma-glutamyltranspeptidase 4572774..4574714 Mycobacterium marinum M 6227986 YP_001851985.1 CDS MMAR_3714 NC_010612.1 4574806 4576809 D function unknown but domain identity suggests a role in transporting oligopeptides as signals across the membrane; hypothetical protein 4574806..4576809 Mycobacterium marinum M 6227987 YP_001851986.1 CDS cysA1 NC_010612.1 4576838 4577947 R involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for energy coupling to the transport system; sulfate-transport ABC transporter ATP-binding protein CysA1 complement(4576838..4577947) Mycobacterium marinum M 6227988 YP_001851987.1 CDS cysW NC_010612.1 4577944 4578762 R involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for the translocation of the substrate across the membrane; sulfate-transport integral membrane protein ABC transporter CysW complement(4577944..4578762) Mycobacterium marinum M 6227989 YP_001851988.1 CDS cysT NC_010612.1 4578759 4579661 R involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for the translocation of the substrate across the membrane; sulfate-transport integral membrane protein ABC transporter CysT complement(4578759..4579661) Mycobacterium marinum M 6227990 YP_001851989.1 CDS subI NC_010612.1 4579658 4580707 R involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import); sulfate-binding lipoprotein SubI complement(4579658..4580707) Mycobacterium marinum M 6227991 YP_001851990.1 CDS MMAR_3719 NC_010612.1 4581057 4581251 R hypothetical protein complement(4581057..4581251) Mycobacterium marinum M 6227992 YP_001851991.1 CDS MMAR_3720 NC_010612.1 4581387 4582565 D function unknown, probably involved in cellular metabolism; hypothetical protein 4581387..4582565 Mycobacterium marinum M 6227993 YP_001851992.1 CDS MMAR_3721 NC_010612.1 4582636 4584702 D glycosyl hydrolase 4582636..4584702 Mycobacterium marinum M 6227994 YP_001851993.1 CDS lppR NC_010612.1 4584720 4585493 R lipoprotein LppR complement(4584720..4585493) Mycobacterium marinum M 6227995 YP_001851994.1 CDS lppR_1 NC_010612.1 4585493 4586236 R lipoprotein LppR complement(4585493..4586236) Mycobacterium marinum M 6227996 YP_001851995.1 CDS lepA NC_010612.1 4586239 4588155 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(4586239..4588155) Mycobacterium marinum M 6227997 YP_001851996.1 CDS MMAR_3725 NC_010612.1 4588189 4588791 D function unknown but domain identity with plasmid maintenance toxin superfamily; hypothetical protein 4588189..4588791 Mycobacterium marinum M 6227998 YP_001851997.1 CDS MMAR_3726 NC_010612.1 4588833 4589261 R function unknown but contains 2 Cbs domains; transcriptional regulator complement(4588833..4589261) Mycobacterium marinum M 6227999 YP_001851998.1 CDS MMAR_3727 NC_010612.1 4589487 4590326 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 4589487..4590326 Mycobacterium marinum M 6228000 YP_001851999.1 CDS MMAR_3728 NC_010612.1 4590489 4592093 D PE-PGRS family protein 4590489..4592093 Mycobacterium marinum M 6228001 YP_001852000.1 CDS MMAR_3729 NC_010612.1 4592197 4593624 D PE-PGRS family protein 4592197..4593624 Mycobacterium marinum M 6228002 YP_001852001.1 CDS MMAR_3730 NC_010612.1 4593629 4594468 R function unknown but based on domain identity it may cross-link proteins through an acyl-transfer reaction between the gamma-carboxamide group of peptide-bound glutamine and the epsilon-amino group of peptide-bound lysine; putative transglutaminase-like protein complement(4593629..4594468) Mycobacterium marinum M 6228003 YP_001852002.1 CDS MMAR_3731 NC_010612.1 4594468 4595445 R hypothetical protein complement(4594468..4595445) Mycobacterium marinum M 6228004 YP_001852003.1 CDS MMAR_3732 NC_010612.1 4595445 4597118 R function unknown but contains two glutathione synthetase ATP-binding superfamily domain-like sequences; hypothetical protein complement(4595445..4597118) Mycobacterium marinum M 6228005 YP_001852004.1 CDS rpsT NC_010612.1 4597257 4597520 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 4597257..4597520 Mycobacterium marinum M 6228006 YP_001852005.1 CDS holA NC_010612.1 4597593 4598570 R possible role in DNA replication. two superfamily domains detected. N-term contains P-loop nucleoside triphosphate hydrolase. C-term contains DNA polymerase III, delta subunit; hypothetical protein complement(4597593..4598570) Mycobacterium marinum M 6228007 YP_001852006.1 CDS comEC NC_010612.1 4598583 4600148 R function unknown, predicted membrane metal-binding protein; membrane metal-binding protein ComEC complement(4598583..4600148) Mycobacterium marinum M 6228008 YP_001852007.1 CDS comEA NC_010612.1 4600166 4601041 R function unknown but domain identity suggests ComEA. a family of DNA uptake protein and related DNA- binding proteins involved in DNA replication, recombination, and repair; membrane protein ComEA complement(4600166..4601041) Mycobacterium marinum M 6228009 YP_001852008.1 CDS fadE17_1 NC_010612.1 4601296 4602462 D function unknown, but probable involvement in lipid metabolism; acyl-CoA dehydrogenase FadE17 4601296..4602462 Mycobacterium marinum M 6228010 YP_001852009.1 CDS fadE18_2 NC_010612.1 4602470 4603588 D function unknown, but supposed involvement in lipid metabolism; acyl-CoA dehydrogenase FadE18 4602470..4603588 Mycobacterium marinum M 6228011 YP_001852010.1 CDS MMAR_3739 NC_010612.1 4603844 4604944 D function unknown but contains FAD/NAD(P)-binding superfamily domain; hypothetical protein 4603844..4604944 Mycobacterium marinum M 6228012 YP_001852011.1 CDS eis NC_010612.1 4605167 4606360 R supposed involved in intracellular survival. possibly associated with the cell surface and secreted; hypothetical protein complement(4605167..4606360) Mycobacterium marinum M 6228013 YP_001852012.1 CDS MMAR_3741 NC_010612.1 4606490 4607539 D function unknown but contains superfamily NAD(P)- binding Rossmann-fold domains; hypothetical protein 4606490..4607539 Mycobacterium marinum M 6228014 YP_001852013.1 CDS MMAR_3742 NC_010612.1 4607542 4608318 D hypothetical protein 4607542..4608318 Mycobacterium marinum M 6228015 YP_001852014.1 CDS mmpS5_1 NC_010612.1 4608634 4609077 D membrane protein MmpS5 4608634..4609077 Mycobacterium marinum M 6228016 YP_001852015.1 CDS mmpL4_1 NC_010612.1 4609074 4611995 D function unknown. thought to be involved in lipid transport; transmembrane transport protein MmpL 4609074..4611995 Mycobacterium marinum M 6228017 YP_001852016.1 CDS MMAR_3745 NC_010612.1 4612031 4612876 R function unknown, contains DegV-like superfamily domain; hypothetical protein complement(4612031..4612876) Mycobacterium marinum M 6228018 YP_001852017.1 CDS MMAR_3746 NC_010612.1 4612880 4613635 R function unknown but contains esterase/acetylhydrolase superfamily domain; hypothetical protein complement(4612880..4613635) Mycobacterium marinum M 6228019 YP_001852018.1 CDS gpm_1 NC_010612.1 4613625 4614299 R involved in glycolysis [catalytic activity: 2- phosphoglycerate + 2,3-diphosphoglycerate = 3- phosphoglycerate + 2,3-diphosphoglycerate]; phosphoglycerate mutase complement(4613625..4614299) Mycobacterium marinum M 6228020 YP_001852019.1 CDS MMAR_3748 NC_010612.1 4614296 4614685 R hypothetical protein complement(4614296..4614685) Mycobacterium marinum M 6228021 YP_001852020.1 CDS nadD NC_010612.1 4614682 4615329 R involved in NAD biosynthesis; catalyzes the reversible adenylation of nicotinate mononucleotide [catalytic activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+)]; nicotinate-nucleotide adenylyltransferase NadD complement(4614682..4615329) Mycobacterium marinum M 6228022 YP_001852021.1 CDS MMAR_3750 NC_010612.1 4615565 4616602 D hypothetical protein 4615565..4616602 Mycobacterium marinum M 6228023 YP_001852022.1 CDS MMAR_3751 NC_010612.1 4616613 4618052 R function unknown but contains a von willebrand factor type a conserved domain; hypothetical protein complement(4616613..4618052) Mycobacterium marinum M 6228024 YP_001852023.1 CDS MMAR_3752 NC_010612.1 4618066 4618941 R function unknown but contains aaa ATPase domain containing von willebrand factor type a (vWA) domain; hypothetical protein complement(4618066..4618941) Mycobacterium marinum M 6228025 YP_001852024.1 CDS proA NC_010612.1 4618975 4620246 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(4618975..4620246) Mycobacterium marinum M 6228026 YP_001852025.1 CDS MMAR_3754 NC_010612.1 4620338 4621732 R hypothetical protein complement(4620338..4621732) Mycobacterium marinum M 6228027 YP_001852026.1 CDS MMAR_3755 NC_010612.1 4621729 4623921 R generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp; adenylate or guanylate cyclase complement(4621729..4623921) Mycobacterium marinum M 6228028 YP_001852027.1 CDS MMAR_3756 NC_010612.1 4624087 4625487 R function unknown but domain identity suggests that it may be a mechanosensitive (ms) ion channel protein with a C-term putative cyclic nucleotide (camp or cGMP) binding domain; hypothetical protein complement(4624087..4625487) Mycobacterium marinum M 6228029 YP_001852028.1 CDS MMAR_3757 NC_010612.1 4625484 4627643 R generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp; adenylate or guanylate cyclase complement(4625484..4627643) Mycobacterium marinum M 6228030 YP_001852029.1 CDS MMAR_3758 NC_010612.1 4628393 4630975 D PE-PGRS family protein 4628393..4630975 Mycobacterium marinum M 6228031 YP_001852030.1 CDS nadE NC_010612.1 4631088 4633130 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(4631088..4633130) Mycobacterium marinum M 6228032 YP_001852031.1 CDS MMAR_3760 NC_010612.1 4633422 4634291 D function unknown, involved in transcriptional mechanism; Sir2-like regulatory protein 4633422..4634291 Mycobacterium marinum M 6228033 YP_001852032.1 CDS cyp268A2 NC_010612.1 4634378 4635637 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 268A2 Cyp268A2 complement(4634378..4635637) Mycobacterium marinum M 6228034 YP_001852033.1 CDS MMAR_3762 NC_010612.1 4635766 4636404 D function unknown. possibly involved in transcriptional mechanism; AcrR family transcriptional regulator 4635766..4636404 Mycobacterium marinum M 6228035 YP_001852034.1 CDS MMAR_3763 NC_010612.1 4636475 4641919 R PE-PGRS family protein complement(4636475..4641919) Mycobacterium marinum M 6228036 YP_001852035.1 CDS proB NC_010612.1 4642271 4643377 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(4642271..4643377) Mycobacterium marinum M 6228037 YP_001852036.1 CDS obgE NC_010612.1 4643377 4644816 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(4643377..4644816) Mycobacterium marinum M 6228038 YP_001852037.1 CDS rpmA NC_010612.1 4644920 4645186 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(4644920..4645186) Mycobacterium marinum M 6228039 YP_001852038.1 CDS rplU NC_010612.1 4645204 4645515 R involved in translation mechanisms; 50S ribosomal protein L21 complement(4645204..4645515) Mycobacterium marinum M 6228040 YP_001852039.1 CDS rne NC_010612.1 4645788 4648841 R thought to be involved in several cellular process; ribonuclease E Rne complement(4645788..4648841) Mycobacterium marinum M 6228041 YP_001852040.1 CDS ndk NC_010612.1 4649168 4649578 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(4649168..4649578) Mycobacterium marinum M 6228042 YP_001852041.1 CDS MMAR_3770 NC_010612.1 4649642 4650046 R hypothetical protein complement(4649642..4650046) Mycobacterium marinum M 6228043 YP_001852042.1 CDS folC NC_010612.1 4650043 4651497 R conversion of folates to polyglutamate derivatives. bacteria require folate for the biosynthesis of glycine, methionine, formyl-met-tRNA, thymidylates, purines, and pantothenate [catalytic activity: ATP + {tetrahydrofolyl- [Glu]}(N) + L-glutamate = ADP + phosphate + {tetrahydrofolyl-[Glu]}(n+1)]; folylpolyglutamate synthase protein FolC complement(4650043..4651497) Mycobacterium marinum M 6228044 YP_001852043.1 CDS valS NC_010612.1 4651494 4654154 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(4651494..4654154) Mycobacterium marinum M 6228045 YP_001852044.1 CDS MMAR_3773 NC_010612.1 4654229 4654858 R function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain; hypothetical protein complement(4654229..4654858) Mycobacterium marinum M 6228046 YP_001852045.1 CDS MMAR_3774 NC_010612.1 4654936 4655532 R hypothetical protein complement(4654936..4655532) Mycobacterium marinum M 6228047 YP_001852046.1 CDS MMAR_3775 NC_010612.1 4655640 4656896 R function unknown but contains potential saccharopine-like dehydrogenase domain; hypothetical protein complement(4655640..4656896) Mycobacterium marinum M 6228048 YP_001852047.1 CDS rpfE NC_010612.1 4657063 4657794 R thought to promote the resuscitation and growth of dormant, nongrowing cells. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis; resuscitation-promoting factor RpfE complement(4657063..4657794) Mycobacterium marinum M 6228049 YP_001852048.1 CDS MMAR_3778 NC_010612.1 4659014 4659874 R flavin-dependent oxidoreductase complement(4659014..4659874) Mycobacterium marinum M 6228051 YP_001852049.1 CDS MMAR_3779 NC_010612.1 4659984 4668914 R production of unknown peptide. Predict 3 modules with domain structure (C-A-M-T, C-A-T, C); non-ribosomal peptide synthetase complement(4659984..4668914) Mycobacterium marinum M 6228052 YP_001852050.1 CDS MMAR_3780 NC_010612.1 4669337 4670821 R monooxygenase complement(4669337..4670821) Mycobacterium marinum M 6228053 YP_001852051.1 CDS MMAR_3782 NC_010612.1 4671921 4673126 R Single copy element; transposition of an insertion sequence (IS110 family); transposase complement(4671921..4673126) Mycobacterium marinum M 6228055 YP_001852052.1 CDS MMAR_3784 NC_010612.1 4674145 4674966 R Single copy element; transposition of an ISMyma01-like element; transposase, ISMyma01_aa2-like protein complement(4674145..4674966) Mycobacterium marinum M 6228057 YP_001852053.1 CDS MMAR_3785 NC_010612.1 4674996 4675283 R transposition of an ISMyma01-like element; transposase, ISMyma01_aa1-like protein complement(4674996..4675283) Mycobacterium marinum M 6228058 YP_001852054.1 CDS MMAR_3786 NC_010612.1 4675406 4676575 D Single copy element; transposition of an IS3 family insertion sequence; transposase 4675406..4676575 Mycobacterium marinum M 6228059 YP_001852055.1 CDS MMAR_3787 NC_010612.1 4676588 4676863 D hypothetical protein 4676588..4676863 Mycobacterium marinum M 6228060 YP_001852056.1 CDS MMAR_3790 NC_010612.1 4677602 4678402 R function unknown but this protein family are hydrolase enzymes - isochorismatase is an enzyme that catalyzes the conversion of isochorismate to 2,3- dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond; isochorismatase family protein complement(4677602..4678402) Mycobacterium marinum M 6228062 YP_001852057.1 CDS MMAR_3792 NC_010612.1 4679594 4680643 D single copy element; transposition of an IS110 family insertion sequence; transposase 4679594..4680643 Mycobacterium marinum M 6228064 YP_001852058.1 CDS MMAR_3793 NC_010612.1 4680623 4680955 R single copy element. maybe a partial IS as C-term subunit tranposase is absent.; transposition of an insertion sequence; transposase complement(4680623..4680955) Mycobacterium marinum M 6228065 YP_001852059.1 CDS MMAR_3794 NC_010612.1 4681054 4681728 R transcriptional regulatory protein complement(4681054..4681728) Mycobacterium marinum M 6228066 YP_001852060.1 CDS MMAR_3795 NC_010612.1 4681990 4683639 R thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase complement(4681990..4683639) Mycobacterium marinum M 6228067 YP_001852061.1 CDS MMAR_3796 NC_010612.1 4685825 4691278 D polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, Ata, DH, KR, ACP; type I modular polyketide synthase 4685825..4691278 Mycobacterium marinum M 6228068 YP_001852062.1 CDS MMAR_3797 NC_010612.1 4691294 4696897 D polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, ATP, DH, KR, ACP; type I modular polyketide synthase 4691294..4696897 Mycobacterium marinum M 6228069 YP_001852063.1 CDS MMAR_3798 NC_010612.1 4696935 4713422 D polyketide synthase involved in lipid synthesis. three extension modules, domain arrangement: KS, Ata, DH, ER, KR, ACP; KS ATP, KR, ACP; KS ATP, DH, KR, ACP; type I modular polyketide synthase 4696935..4713422 Mycobacterium marinum M 6228070 YP_001852064.1 CDS MMAR_3799 NC_010612.1 4713412 4719519 D polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, Ata, DH, KR, ACP; type I modular polyketide synthase 4713412..4719519 Mycobacterium marinum M 6228071 YP_001852065.1 CDS MMAR_3800 NC_010612.1 4719544 4720494 D function unknown role, perhaps as an acyltransferase or condensase in prodction of secondary metabolite from this locus. this locus is predicted to produce a Nrp:PKS fusion. the PKS product is an apolar hexaketide; beta-ketoacyl synthase-like protein 4719544..4720494 Mycobacterium marinum M 6228072 YP_001852066.1 CDS mobA NC_010612.1 4720902 4721507 R MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A complement(4720902..4721507) Mycobacterium marinum M 6228073 YP_001852067.1 CDS porB NC_010612.1 4721509 4722600 R catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta complement(4721509..4722600) Mycobacterium marinum M 6228074 YP_001852068.1 CDS porA NC_010612.1 4722649 4724610 R function unknown, probably involved in cellular metabolism; pyruvate:ferredoxin oxidoreductase, PorA, alpha subunit complement(4722649..4724610) Mycobacterium marinum M 6228075 YP_001852069.1 CDS MMAR_3804 NC_010612.1 4724943 4726241 R thought to be involved in transport of undeterminated substrate (possibly sugar) across the membrane. responsible for the translocation of the substrate across the membrane; integral membrane transport protein complement(4724943..4726241) Mycobacterium marinum M 6228076 YP_001852070.1 CDS clpX NC_010612.1 4726251 4727531 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(4726251..4727531) Mycobacterium marinum M 6228077 YP_001852071.1 CDS MMAR_3806 NC_010612.1 4728257 4729831 D thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane; integral membrane transport protein 4728257..4729831 Mycobacterium marinum M 6228078 YP_001852072.1 CDS clpP2 NC_010612.1 4729888 4730523 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(4729888..4730523) Mycobacterium marinum M 6228079 YP_001852073.1 CDS clpP NC_010612.1 4730520 4731116 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(4730520..4731116) Mycobacterium marinum M 6228080 YP_001852074.1 CDS tig NC_010612.1 4731239 4732693 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(4731239..4732693) Mycobacterium marinum M 6228081 YP_001852075.1 CDS lipP NC_010612.1 4733075 4734259 D function unknown, lipolytic enzyme involved in cellular metabolism; esterase/lipase LipP 4733075..4734259 Mycobacterium marinum M 6228084 YP_001852076.1 CDS MMAR_3811 NC_010612.1 4734343 4734702 R hypothetical protein complement(4734343..4734702) Mycobacterium marinum M 6228085 YP_001852077.1 CDS MMAR_3812 NC_010612.1 4734830 4735636 R hydrolyses DNA (this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents); formamidopyrimidine-DNA glycosylase complement(4734830..4735636) Mycobacterium marinum M 6228086 YP_001852078.1 CDS rpiB NC_010612.1 4735645 4736124 R catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B complement(4735645..4736124) Mycobacterium marinum M 6228087 YP_001852079.1 CDS dctA NC_010612.1 4736210 4737580 R involved in the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane. responsible for the translocation of the substrate across the membrane; C4-dicarboxylate-transport transmembrane protein DctA complement(4736210..4737580) Mycobacterium marinum M 6228088 YP_001852080.1 CDS MMAR_3815 NC_010612.1 4737712 4738335 R function unknown but contains a DSBA-like thioredoxin domain; hypothetical protein complement(4737712..4738335) Mycobacterium marinum M 6228089 YP_001852081.1 CDS MMAR_3816 NC_010612.1 4738436 4740154 R PE-PGRS family protein complement(4738436..4740154) Mycobacterium marinum M 6228090 YP_001852082.1 CDS pepN NC_010612.1 4740430 4743009 D aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates); aminopeptidase N PepN 4740430..4743009 Mycobacterium marinum M 6228091 YP_001852083.1 CDS MMAR_3818 NC_010612.1 4743046 4743549 R hypothetical protein complement(4743046..4743549) Mycobacterium marinum M 6228092 YP_001852084.1 CDS MMAR_3819 NC_010612.1 4743500 4743742 R hypothetical protein complement(4743500..4743742) Mycobacterium marinum M 6228093 YP_001852085.1 CDS MMAR_3820 NC_010612.1 4743835 4744476 R function unknown but contains McrA, restriction endonuclease domain; hypothetical protein complement(4743835..4744476) Mycobacterium marinum M 6228094 YP_001852086.1 CDS glbO NC_010612.1 4744630 4745016 D oxygen carrier, involved in oxygen transport; globin (oxygen-binding protein) GlbO 4744630..4745016 Mycobacterium marinum M 6228095 YP_001852087.1 CDS aglA NC_010612.1 4745016 4746593 D involved in sugar metabolism (hydrolysis of terminal, non-reducing 1,4-linked d-glucose residues with release of d-glucose); alpha-glucosidase AglA 4745016..4746593 Mycobacterium marinum M 6228096 YP_001852088.1 CDS plcB_1 NC_010612.1 4746806 4748362 D hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 4746806..4748362 Mycobacterium marinum M 6228097 YP_001852089.1 CDS choD_1 NC_010612.1 4748390 4750129 R involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)]; cholesterol oxidase ChoD complement(4748390..4750129) Mycobacterium marinum M 6228098 YP_001852090.1 CDS MMAR_3825 NC_010612.1 4750213 4751748 R thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; drug-transport integral membrane protein complement(4750213..4751748) Mycobacterium marinum M 6228099 YP_001852091.1 CDS moeY_1 NC_010612.1 4751745 4753934 R involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD); hypothetical protein complement(4751745..4753934) Mycobacterium marinum M 6228100 YP_001852092.1 CDS MMAR_3827 NC_010612.1 4754446 4755108 R hypothetical protein complement(4754446..4755108) Mycobacterium marinum M 6228101 YP_001852093.1 CDS MMAR_3828 NC_010612.1 4755105 4755521 R function unknown but some identity with thioesterase domains; hypothetical protein complement(4755105..4755521) Mycobacterium marinum M 6228102 YP_001852094.1 CDS gdh NC_010612.1 4755518 4760356 R catabolic GlutDH involved in the utilization of glutamate and other amino acids of the glutamate family. generates 2-oxoglutarate from L-glutamate [catalytic activity: L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH]; NAD-dependent glutamate dehydrogenase Gdh complement(4755518..4760356) Mycobacterium marinum M 6228103 YP_001852095.1 CDS MMAR_3830 NC_010612.1 4760517 4762193 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein complement(4760517..4762193) Mycobacterium marinum M 6228104 YP_001852096.1 CDS MMAR_3831 NC_010612.1 4762261 4762779 R function unknown but may play a role in DNA replication, recombination, and repair; hypothetical protein complement(4762261..4762779) Mycobacterium marinum M 6228105 YP_001852097.1 CDS erg3_2 NC_010612.1 4763392 4764321 D involved in lipid desaturation; membrane-bound C-5 sterol desaturase 4763392..4764321 Mycobacterium marinum M 6228106 YP_001852098.1 CDS plsB2 NC_010612.1 4764379 4766745 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(4764379..4766745) Mycobacterium marinum M 6228107 YP_001852099.1 CDS plsC NC_010612.1 4766742 4768697 R N-terminus: could be generate serine and phosphate from phosphoserine; may catalyze the last step in the biosynthesis of serine from carbohydrates (the reaction mechanism could be proceed via the formation of a phosphoryl-enzyme intermediates) [catalytic activity 1: phosphoserine + H(2)O = serine + phosphate]. mid-section: involved in phospholipid biosynthesis (at the second step); converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [catalytic activity 2: acyl-CoA + 1-acyl-SN- glycerol 3-phosphate = CoA + 1,2-diacyl-SN-glycerol 3- phosphate]. c-terminus: contains tola protein domain homology. may serve to anchor this protein in the cm; bifunctional transmembrane phospholipid biosynthesis enzyme PlsC complement(4766742..4768697) Mycobacterium marinum M 6228108 YP_001852100.1 CDS MMAR_3835 NC_010612.1 4768694 4770157 R function unknown but N-term contains a CoA- dependanant acyltransferase domain; hypothetical protein complement(4768694..4770157) Mycobacterium marinum M 6228109 YP_001852101.1 CDS lipQ NC_010612.1 4770390 4771637 R function unknown, lipolytic enzyme involved in cellular metabolism; carboxylesterase LipQ complement(4770390..4771637) Mycobacterium marinum M 6228110 YP_001852102.1 CDS MMAR_3837 NC_010612.1 4772150 4772857 D hydrolyzes cutin; cutinase 4772150..4772857 Mycobacterium marinum M 6228112 YP_001852103.1 CDS MMAR_5558 NC_010612.1 4772989 4773300 R hypothetical protein complement(4772989..4773300) Mycobacterium marinum M 6228113 YP_001852104.1 CDS cobQ1 NC_010612.1 4773503 4774978 R catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase complement(4773503..4774978) Mycobacterium marinum M 6228114 YP_001852105.1 CDS MMAR_3839 NC_010612.1 4775745 4776089 D hypothetical protein 4775745..4776089 Mycobacterium marinum M 6228115 YP_001852106.1 CDS MMAR_3840 NC_010612.1 4776401 4776763 D hypothetical protein 4776401..4776763 Mycobacterium marinum M 6228116 YP_001852107.1 CDS mmaA5 NC_010612.1 4776782 4777651 R involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 5 MmaA5 complement(4776782..4777651) Mycobacterium marinum M 6228117 YP_001852108.1 CDS pdhC NC_010612.1 4777970 4779139 R involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; branched-chain alpha-keto acid dehydrogenase subunit E2 complement(4777970..4779139) Mycobacterium marinum M 6228118 YP_001852109.1 CDS pdhB NC_010612.1 4779136 4780182 R involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component subunit PdhB complement(4779136..4780182) Mycobacterium marinum M 6228119 YP_001852110.1 CDS pdhA NC_010612.1 4780193 4781284 R involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component subunit PdhA complement(4780193..4781284) Mycobacterium marinum M 6228120 YP_001852111.1 CDS citE NC_010612.1 4781625 4782446 R interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate (pro-3S)-lyase subunit beta complement(4781625..4782446) Mycobacterium marinum M 6228121 YP_001852112.1 CDS MMAR_3846 NC_010612.1 4782443 4782949 R function unknown but contains a central MaoC, acyl dehydratase domain; hypothetical protein complement(4782443..4782949) Mycobacterium marinum M 6228122 YP_001852113.1 CDS fadE19 NC_010612.1 4782946 4784112 R function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein; acyl-CoA dehydrogenase FadE19 complement(4782946..4784112) Mycobacterium marinum M 6228123 YP_001852114.1 CDS accA1 NC_010612.1 4784119 4786128 R this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein]; acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA1 complement(4784119..4786128) Mycobacterium marinum M 6228124 YP_001852115.1 CDS accD1 NC_010612.1 4786132 4787712 R involved in fatty acid metabolism; acetyl-/propionyl-CoA carboxylase subunit beta complement(4786132..4787712) Mycobacterium marinum M 6228125 YP_001852116.1 CDS scoB NC_010612.1 4787709 4788356 R involved in various degradation and synthesis [catalytic activity: succinyl-CoA + a 3-OXO acid = succinate + a 3-OXO-acyl-CoA]; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta ScoB complement(4787709..4788356) Mycobacterium marinum M 6228126 YP_001852117.1 CDS scoA NC_010612.1 4788459 4789205 R involved in fatty acid degradation/synthesis [catalytic activity: succinyl-CoA + a 3-OXO acid = succinate + a 3-OXO-acyl-CoA]; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha ScoA complement(4788459..4789205) Mycobacterium marinum M 6228127 YP_001852118.1 CDS fadD35 NC_010612.1 4789326 4790969 R function unknown, but involved in lipid degradation; AMP-binding protein complement(4789326..4790969) Mycobacterium marinum M 6228128 YP_001852119.1 CDS MMAR_3853 NC_010612.1 4791074 4791709 D involved in transcriptional mechanism; putative regulatory protein 4791074..4791709 Mycobacterium marinum M 6228129 YP_001852120.1 CDS MMAR_3854 NC_010612.1 4791940 4792731 D proline rich membrane protein 4791940..4792731 Mycobacterium marinum M 6228130 YP_001852121.1 CDS MMAR_3855 NC_010612.1 4792728 4794056 R integral membrane leucine and alanine rich protein complement(4792728..4794056) Mycobacterium marinum M 6228131 YP_001852122.1 CDS MMAR_3856 NC_010612.1 4794152 4794958 D function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 4794152..4794958 Mycobacterium marinum M 6228132 YP_001852123.1 CDS MMAR_3857 NC_010612.1 4795064 4796035 D transposition of ISMyma04; transposase for ISMyma04 4795064..4796035 Mycobacterium marinum M 6228133 YP_001852124.1 CDS MMAR_3858 NC_010612.1 4796053 4797660 R function unknown but contains ATPase domain; hypothetical protein complement(4796053..4797660) Mycobacterium marinum M 6228134 YP_001852125.1 CDS orn NC_010612.1 4797775 4798422 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4797775..4798422 Mycobacterium marinum M 6228135 YP_001852126.1 CDS MMAR_3860 NC_010612.1 4798608 4799309 R hypothetical protein complement(4798608..4799309) Mycobacterium marinum M 6228137 YP_001852127.1 CDS MMAR_3861 NC_010612.1 4799442 4800062 R involved in transcriptional mechanism; putative regulatory protein complement(4799442..4800062) Mycobacterium marinum M 6228138 YP_001852128.1 CDS yrbE5A NC_010612.1 4800360 4801229 D function unknown, YrbE family protein that is similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component; YrbE family protein, YrbE5A 4800360..4801229 Mycobacterium marinum M 6228139 YP_001852129.1 CDS MMAR_3863 NC_010612.1 4801231 4802094 D function unknown but similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component; integral ABC-type transport protein 4801231..4802094 Mycobacterium marinum M 6228140 YP_001852130.1 CDS mce5A NC_010612.1 4802118 4803650 D this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce protein, Mce5A 4802118..4803650 Mycobacterium marinum M 6228141 YP_001852131.1 CDS mce5B NC_010612.1 4803647 4804702 D this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce family protein, Mce5B 4803647..4804702 Mycobacterium marinum M 6228142 YP_001852132.1 CDS mce5C NC_010612.1 4804695 4805750 D this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce family protein, Mce5C 4804695..4805750 Mycobacterium marinum M 6228143 YP_001852133.1 CDS mce5D NC_010612.1 4805747 4806862 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce5D 4805747..4806862 Mycobacterium marinum M 6228144 YP_001852134.1 CDS mce5E NC_010612.1 4806862 4808067 D this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce family protein, Mce5E 4806862..4808067 Mycobacterium marinum M 6228145 YP_001852135.1 CDS mce5F NC_010612.1 4808064 4809314 D this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce family protein Mce5F 4808064..4809314 Mycobacterium marinum M 6228146 YP_001852136.1 CDS MMAR_3870 NC_010612.1 4809342 4810055 D hypothetical protein 4809342..4810055 Mycobacterium marinum M 6228147 YP_001852137.1 CDS MMAR_3871 NC_010612.1 4810074 4810853 D hypothetical protein 4810074..4810853 Mycobacterium marinum M 6228148 YP_001852138.1 CDS lppS NC_010612.1 4810855 4812054 R lipoprotein LppS complement(4810855..4812054) Mycobacterium marinum M 6228149 YP_001852139.1 CDS MMAR_5557 NC_010612.1 4812058 4812195 D hypothetical protein 4812058..4812195 Mycobacterium marinum M 6228150 YP_001852140.1 CDS MMAR_3873 NC_010612.1 4812550 4812897 D hypothetical protein 4812550..4812897 Mycobacterium marinum M 6228152 YP_001852141.1 CDS MMAR_3874 NC_010612.1 4812894 4813187 D hypothetical protein 4812894..4813187 Mycobacterium marinum M 6228153 YP_001852142.1 CDS MMAR_3875 NC_010612.1 4813205 4814056 D member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins; PE-PGRS family protein 4813205..4814056 Mycobacterium marinum M 6228154 YP_001852143.1 CDS MMAR_3876 NC_010612.1 4814152 4814427 R hypothetical protein complement(4814152..4814427) Mycobacterium marinum M 6228155 YP_001852144.1 CDS MMAR_3877 NC_010612.1 4814444 4814854 R hypothetical protein complement(4814444..4814854) Mycobacterium marinum M 6228156 YP_001852145.1 CDS MMAR_3878 NC_010612.1 4815193 4816152 R hypothetical protein complement(4815193..4816152) Mycobacterium marinum M 6228157 YP_001852146.1 CDS MMAR_3879 NC_010612.1 4816364 4817587 R hypothetical protein complement(4816364..4817587) Mycobacterium marinum M 6228158 YP_001852147.1 CDS MMAR_3880 NC_010612.1 4817587 4817814 R hypothetical protein complement(4817587..4817814) Mycobacterium marinum M 6228159 YP_001852148.1 CDS MMAR_3881 NC_010612.1 4818132 4818419 R hypothetical protein complement(4818132..4818419) Mycobacterium marinum M 6228160 YP_001852149.1 CDS MMAR_3882 NC_010612.1 4818419 4822000 R bacteriophage membrane protein complement(4818419..4822000) Mycobacterium marinum M 6228161 YP_001852150.1 CDS MMAR_3883 NC_010612.1 4821997 4823682 R bacteriophage membrane protein complement(4821997..4823682) Mycobacterium marinum M 6228162 YP_001852151.1 CDS MMAR_3884 NC_010612.1 4823794 4824150 R hypothetical protein complement(4823794..4824150) Mycobacterium marinum M 6228163 YP_001852152.1 CDS MMAR_3885 NC_010612.1 4824230 4825093 R hypothetical protein complement(4824230..4825093) Mycobacterium marinum M 6228164 YP_001852153.1 CDS MMAR_3886 NC_010612.1 4825093 4830081 R bacteriophage-like membrane protein complement(4825093..4830081) Mycobacterium marinum M 6228165 YP_001852154.1 CDS MMAR_3887 NC_010612.1 4830368 4831090 R hypothetical protein complement(4830368..4831090) Mycobacterium marinum M 6228166 YP_001852155.1 CDS MMAR_3888 NC_010612.1 4831130 4831993 R function unknown; contains a fibronectin type 3 domain; hypothetical protein complement(4831130..4831993) Mycobacterium marinum M 6228167 YP_001852156.1 CDS MMAR_3889 NC_010612.1 4831994 4832227 R hypothetical protein complement(4831994..4832227) Mycobacterium marinum M 6228168 YP_001852157.1 CDS MMAR_3890 NC_010612.1 4832247 4832675 R hypothetical protein complement(4832247..4832675) Mycobacterium marinum M 6228169 YP_001852158.1 CDS MMAR_3891 NC_010612.1 4832707 4833141 R phage-like protein complement(4832707..4833141) Mycobacterium marinum M 6228170 YP_001852159.1 CDS MMAR_3892 NC_010612.1 4833147 4833554 R phage-like protein complement(4833147..4833554) Mycobacterium marinum M 6228171 YP_001852160.1 CDS MMAR_3893 NC_010612.1 4833547 4833954 R hypothetical protein complement(4833547..4833954) Mycobacterium marinum M 6228172 YP_001852161.1 CDS MMAR_3894 NC_010612.1 4833961 4834392 R hypothetical protein complement(4833961..4834392) Mycobacterium marinum M 6228173 YP_001852162.1 CDS MMAR_3895 NC_010612.1 4834389 4834706 R phage-like protein complement(4834389..4834706) Mycobacterium marinum M 6228174 YP_001852163.1 CDS MMAR_3896 NC_010612.1 4834730 4835791 R may be involved in phage capsid construction; phage structural protein complement(4834730..4835791) Mycobacterium marinum M 6228175 YP_001852164.1 CDS MMAR_3897 NC_010612.1 4835806 4836516 R phage-like protein complement(4835806..4836516) Mycobacterium marinum M 6228176 YP_001852165.1 CDS MMAR_3898 NC_010612.1 4836534 4837244 R hypothetical protein complement(4836534..4837244) Mycobacterium marinum M 6228177 YP_001852166.1 CDS MMAR_3899 NC_010612.1 4837346 4838563 R hypothetical protein complement(4837346..4838563) Mycobacterium marinum M 6228178 YP_001852167.1 CDS MMAR_3900 NC_010612.1 4838547 4840118 R hypothetical protein complement(4838547..4840118) Mycobacterium marinum M 6228179 YP_001852168.1 CDS MMAR_3901 NC_010612.1 4840132 4841805 R function unknown - possible role in phage replication; phage terminase-like large subunit protein complement(4840132..4841805) Mycobacterium marinum M 6228180 YP_001852169.1 CDS MMAR_3902 NC_010612.1 4841812 4842288 R hypothetical protein complement(4841812..4842288) Mycobacterium marinum M 6228181 YP_001852170.1 CDS MMAR_3903 NC_010612.1 4842522 4843199 R hypothetical protein complement(4842522..4843199) Mycobacterium marinum M 6228182 YP_001852171.1 CDS MMAR_3904 NC_010612.1 4843231 4843587 R hypothetical protein complement(4843231..4843587) Mycobacterium marinum M 6228183 YP_001852172.1 CDS MMAR_3905 NC_010612.1 4843587 4843814 R hypothetical protein complement(4843587..4843814) Mycobacterium marinum M 6228184 YP_001852173.1 CDS MMAR_3906 NC_010612.1 4843840 4844403 R hypothetical protein complement(4843840..4844403) Mycobacterium marinum M 6228185 YP_001852174.1 CDS MMAR_3908 NC_010612.1 4844802 4845194 D hypothetical protein 4844802..4845194 Mycobacterium marinum M 6228186 YP_001852175.1 CDS MMAR_3909 NC_010612.1 4845196 4845762 R hypothetical protein complement(4845196..4845762) Mycobacterium marinum M 6228187 YP_001852176.1 CDS MMAR_3910 NC_010612.1 4845782 4846069 R hypothetical protein complement(4845782..4846069) Mycobacterium marinum M 6228188 YP_001852177.1 CDS MMAR_3911 NC_010612.1 4846099 4846251 R hypothetical protein complement(4846099..4846251) Mycobacterium marinum M 6228189 YP_001852178.1 CDS MMAR_3912 NC_010612.1 4847507 4848031 R involved in transcriptional mechanism; transcriptional regulatory protein complement(4847507..4848031) Mycobacterium marinum M 6228190 YP_001852179.1 CDS MMAR_3913 NC_010612.1 4848674 4849135 R hypothetical protein complement(4848674..4849135) Mycobacterium marinum M 6228191 YP_001852180.1 CDS MMAR_3914 NC_010612.1 4849132 4849374 R hypothetical protein complement(4849132..4849374) Mycobacterium marinum M 6228192 YP_001852181.1 CDS MMAR_3915 NC_010612.1 4849371 4849610 R hypothetical protein complement(4849371..4849610) Mycobacterium marinum M 6228193 YP_001852182.1 CDS MMAR_3916 NC_010612.1 4849603 4850187 R hypothetical protein complement(4849603..4850187) Mycobacterium marinum M 6228194 YP_001852183.1 CDS MMAR_3917 NC_010612.1 4850180 4851325 R hypothetical protein complement(4850180..4851325) Mycobacterium marinum M 6228195 YP_001852184.1 CDS MMAR_3919 NC_010612.1 4851643 4851963 R hypothetical protein complement(4851643..4851963) Mycobacterium marinum M 6228196 YP_001852185.1 CDS MMAR_3921 NC_010612.1 4852346 4853221 R function unknown; possible role in phage DNA restriction modification system; phage DNA methylase complement(4852346..4853221) Mycobacterium marinum M 6228197 YP_001852186.1 CDS MMAR_3923 NC_010612.1 4853403 4854230 R function unknown; homology suggests possible regulatory protein; hypothetical protein complement(4853403..4854230) Mycobacterium marinum M 6228198 YP_001852187.1 CDS MMAR_3924 NC_010612.1 4854227 4854529 R hypothetical protein complement(4854227..4854529) Mycobacterium marinum M 6228199 YP_001852188.1 CDS MMAR_3925 NC_010612.1 4854529 4854801 R hypothetical protein complement(4854529..4854801) Mycobacterium marinum M 6228200 YP_001852189.1 CDS dnaN_1 NC_010612.1 4854804 4855946 R probably involved in phage genome replication. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. this DNA polymerase also exhibits 3' to 5' exonuclease activity. the beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA [catalytic activity: N deoxynucleoside triphosphate = N diphosphate + {DNA}n]; DNA polymerase III (beta chain) DnaN complement(4854804..4855946) Mycobacterium marinum M 6228201 YP_001852190.1 CDS MMAR_3927 NC_010612.1 4856155 4857282 R Possible role in phage replication. Domain identity with rect family. The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, Erf and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways; RecT-family phage protein complement(4856155..4857282) Mycobacterium marinum M 6228202 YP_001852191.1 CDS MMAR_3928 NC_010612.1 4857279 4857779 R hypothetical protein complement(4857279..4857779) Mycobacterium marinum M 6228203 YP_001852192.1 CDS MMAR_3929 NC_010612.1 4857776 4858855 R hypothetical protein complement(4857776..4858855) Mycobacterium marinum M 6228204 YP_001852193.1 CDS MMAR_3930 NC_010612.1 4858852 4859082 R putative regulatory protein complement(4858852..4859082) Mycobacterium marinum M 6228205 YP_001852194.1 CDS MMAR_3931 NC_010612.1 4859240 4859638 R hypothetical protein complement(4859240..4859638) Mycobacterium marinum M 6228206 YP_001852195.1 CDS MMAR_3932 NC_010612.1 4859635 4859967 R hypothetical protein complement(4859635..4859967) Mycobacterium marinum M 6228207 YP_001852196.1 CDS MMAR_3933 NC_010612.1 4859967 4860353 R hypothetical protein complement(4859967..4860353) Mycobacterium marinum M 6228208 YP_001852197.1 CDS MMAR_3934 NC_010612.1 4860350 4860610 R hypothetical protein complement(4860350..4860610) Mycobacterium marinum M 6228209 YP_001852198.1 CDS MMAR_3935 NC_010612.1 4860673 4861086 R hypothetical protein complement(4860673..4861086) Mycobacterium marinum M 6228210 YP_001852199.1 CDS MMAR_3936 NC_010612.1 4861083 4861307 R hypothetical protein complement(4861083..4861307) Mycobacterium marinum M 6228211 YP_001852200.1 CDS MMAR_3937 NC_010612.1 4861304 4861588 R hypothetical protein complement(4861304..4861588) Mycobacterium marinum M 6228212 YP_001852201.1 CDS MMAR_3938 NC_010612.1 4861585 4861776 R hypothetical protein complement(4861585..4861776) Mycobacterium marinum M 6228213 YP_001852202.1 CDS MMAR_3939 NC_010612.1 4861773 4862048 R hypothetical protein complement(4861773..4862048) Mycobacterium marinum M 6228214 YP_001852203.1 CDS MMAR_3940 NC_010612.1 4862045 4862623 R hypothetical protein complement(4862045..4862623) Mycobacterium marinum M 6228215 YP_001852204.1 CDS MMAR_3941 NC_010612.1 4862620 4862955 R hypothetical protein complement(4862620..4862955) Mycobacterium marinum M 6228216 YP_001852205.1 CDS MMAR_3942 NC_010612.1 4862952 4863188 R hypothetical protein complement(4862952..4863188) Mycobacterium marinum M 6228217 YP_001852206.1 CDS MMAR_3943 NC_010612.1 4863185 4864207 R function unknown; putative role in regulation of transcription; phage antirepressor protein complement(4863185..4864207) Mycobacterium marinum M 6228218 YP_001852207.1 CDS MMAR_3944 NC_010612.1 4864204 4864434 R hypothetical protein complement(4864204..4864434) Mycobacterium marinum M 6228219 YP_001852208.1 CDS MMAR_3945 NC_010612.1 4864431 4864736 R hypothetical protein complement(4864431..4864736) Mycobacterium marinum M 6228220 YP_001852209.1 CDS MMAR_3946 NC_010612.1 4864904 4865470 D hypothetical protein 4864904..4865470 Mycobacterium marinum M 6228221 YP_001852210.1 CDS MMAR_3947 NC_010612.1 4865692 4866378 D contains a DNA binding domain. possibly involved in transcriptional mechanism; transcriptional regulatory protein 4865692..4866378 Mycobacterium marinum M 6228222 YP_001852211.1 CDS MMAR_3948 NC_010612.1 4866349 4867146 R hydrolase complement(4866349..4867146) Mycobacterium marinum M 6228223 YP_001852212.1 CDS MMAR_3949 NC_010612.1 4867181 4867864 D phage membrane protein 4867181..4867864 Mycobacterium marinum M 6228224 YP_001852213.1 CDS MMAR_3950 NC_010612.1 4867853 4869109 R integration of phage genome into host chromosome; phage-related integrase complement(4867853..4869109) Mycobacterium marinum M 6228225 YP_001852214.1 CDS MMAR_3951 NC_010612.1 4869106 4869477 R hypothetical protein complement(4869106..4869477) Mycobacterium marinum M 6228226 YP_001852215.1 CDS MMAR_3952 NC_010612.1 4869671 4870252 R hypothetical protein complement(4869671..4870252) Mycobacterium marinum M 6228227 YP_001852216.1 CDS MMAR_3953 NC_010612.1 4870328 4871212 D function unknown but domain identity suggests PlsC, phosphate acyltransferase. these enzymes function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2- acylglycerolphosphoethanolamine acyltransferase activities; hypothetical protein 4870328..4871212 Mycobacterium marinum M 6228228 YP_001852217.1 CDS MMAR_3954 NC_010612.1 4871405 4873144 D hypothetical protein 4871405..4873144 Mycobacterium marinum M 6228229 YP_001852218.1 CDS MMAR_3955 NC_010612.1 4873256 4873483 R hypothetical protein complement(4873256..4873483) Mycobacterium marinum M 6228230 YP_001852219.1 CDS bcp NC_010612.1 4873591 4874064 D putative antioxidant protein; bacterioferritin comigratory protein Bcp 4873591..4874064 Mycobacterium marinum M 6228231 YP_001852220.1 CDS argE NC_010612.1 4874065 4875390 R deacetylates acetylornithine and hydrolyses N- acetylmethionine; hypothetical protein complement(4874065..4875390) Mycobacterium marinum M 6228232 YP_001852221.1 CDS MMAR_3958 NC_010612.1 4875433 4876575 D involved in unknown signal transduction mechanism; two-component sensor kinase 4875433..4876575 Mycobacterium marinum M 6228233 YP_001852222.1 CDS MMAR_3959 NC_010612.1 4876572 4877228 D regulator part of the two-component regulatory system; two-component transcriptional regulatory protein 4876572..4877228 Mycobacterium marinum M 6228234 YP_001852223.1 CDS MMAR_3960 NC_010612.1 4877290 4879155 D hypothetical protein 4877290..4879155 Mycobacterium marinum M 6228235 YP_001852224.1 CDS acpS NC_010612.1 4879229 4879621 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(4879229..4879621) Mycobacterium marinum M 6228236 YP_001852225.1 CDS fas NC_010612.1 4879650 4888862 R involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH; fatty acid synthase Fas complement(4879650..4888862) Mycobacterium marinum M 6228237 YP_001852226.1 CDS MMAR_3963 NC_010612.1 4889374 4890096 R hypothetical protein complement(4889374..4890096) Mycobacterium marinum M 6228238 YP_001852227.1 CDS MMAR_3964 NC_010612.1 4890338 4891480 D may act to bind either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to a cytochrome C or cytochrome F haem iron; ring-hydroxylating dioxygenase, large terminal subunit 4890338..4891480 Mycobacterium marinum M 6228239 YP_001852228.1 CDS MMAR_3965 NC_010612.1 4891606 4893096 D thought to oxidize a wide variety of aliphatic and aromatic aldehydes; NAD-dependent aldehyde dehydrogenase 4891606..4893096 Mycobacterium marinum M 6228240 YP_001852229.1 CDS maoC NC_010612.1 4893068 4893514 R function unknown role in lipid metabolism; contains a thioesterase/thiol ester dehydratase-isomerase superfamily domain; acyl dehydratase MaoC complement(4893068..4893514) Mycobacterium marinum M 6228241 YP_001852230.1 CDS MMAR_3967 NC_010612.1 4893511 4894047 R function unknown but like D/S ORF it contains a thioesterase/thiol ester dehydrase-isomerase superfmaily domain; hypothetical protein complement(4893511..4894047) Mycobacterium marinum M 6228242 YP_001852231.1 CDS MMAR_3968 NC_010612.1 4894053 4894712 R hypothetical protein complement(4894053..4894712) Mycobacterium marinum M 6228243 YP_001852232.1 CDS cyp269A1 NC_010612.1 4895206 4896417 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 269A1 Cyp269A1 4895206..4896417 Mycobacterium marinum M 6228244 YP_001852233.1 CDS MMAR_3970 NC_010612.1 4896448 4898133 D function unknown, possibly involved in transport of drug across the membrane. contains AraJ, arabinose efflux permease domain identity; hypothetical protein 4896448..4898133 Mycobacterium marinum M 6228245 YP_001852234.1 CDS MMAR_3971 NC_010612.1 4898412 4899539 R function unknown, probably involved in cellular metabolism. contains domain identity to phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases; oxidoreductase complement(4898412..4899539) Mycobacterium marinum M 6228246 YP_001852235.1 CDS MMAR_3972 NC_010612.1 4899821 4902985 R contains an NRP-like adenylation domain; non-ribosomal peptide synthetase complement(4899821..4902985) Mycobacterium marinum M 6228247 YP_001852236.1 CDS fdxD_1 NC_010612.1 4904038 4904229 R ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxD complement(4904038..4904229) Mycobacterium marinum M 6228248 YP_001852237.1 CDS MMAR_3974 NC_010612.1 4904247 4906652 R function unknown but contains acyl-CoA transferases/carnitine dehydratase domain homology; acyl-CoA transferase complement(4904247..4906652) Mycobacterium marinum M 6228249 YP_001852238.1 CDS MMAR_3975 NC_010612.1 4906750 4907571 D involved in transcriptional mechanism; FadR family transcriptional regulator 4906750..4907571 Mycobacterium marinum M 6228250 YP_001852239.1 CDS cyp138A4 NC_010612.1 4908243 4909571 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 138A4 Cyp138A4 4908243..4909571 Mycobacterium marinum M 6228251 YP_001852240.1 CDS MMAR_3977 NC_010612.1 4909661 4911160 D thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; drug-transport integral membrane protein 4909661..4911160 Mycobacterium marinum M 6228252 YP_001852241.1 CDS MMAR_3978 NC_010612.1 4911283 4912131 R coenzyme F420-dependent oxidoreductase complement(4911283..4912131) Mycobacterium marinum M 6228253 YP_001852242.1 CDS MMAR_3979 NC_010612.1 4912215 4913270 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 4912215..4913270 Mycobacterium marinum M 6228254 YP_001852243.1 CDS MMAR_3980 NC_010612.1 4913267 4914376 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 4913267..4914376 Mycobacterium marinum M 6228255 YP_001852244.1 CDS fadE17_2 NC_010612.1 4914380 4915537 D function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase FadE17 4914380..4915537 Mycobacterium marinum M 6228256 YP_001852245.1 CDS MMAR_3982 NC_010612.1 4915534 4916469 D function unknown role in lipid metabolism; acyl-CoA dehydrogenase 4915534..4916469 Mycobacterium marinum M 6228257 YP_001852246.1 CDS MMAR_3983 NC_010612.1 4916466 4917959 D function unknown, but involved in lipid degradation; fatty-acid-CoA ligase 4916466..4917959 Mycobacterium marinum M 6228258 YP_001852247.1 CDS MMAR_3984 NC_010612.1 4918164 4919948 D PPE family protein 4918164..4919948 Mycobacterium marinum M 6228259 YP_001852248.1 CDS MMAR_3985 NC_010612.1 4920249 4920617 D hypothetical protein 4920249..4920617 Mycobacterium marinum M 6228260 YP_001852249.1 CDS MMAR_3986 NC_010612.1 4920837 4921313 D function unknown but contains a ricin-type beta- trefoil domain; hypothetical protein 4920837..4921313 Mycobacterium marinum M 6228261 YP_001852250.1 CDS MMAR_3987 NC_010612.1 4921480 4922499 D function unknown. possibly involved in transcriptional mechanism; putative transcriptional regulatory protein 4921480..4922499 Mycobacterium marinum M 6228262 YP_001852251.1 CDS MMAR_3988 NC_010612.1 4922571 4923776 D metal-dependent hydrolase 4922571..4923776 Mycobacterium marinum M 6228263 YP_001852252.1 CDS MMAR_3989 NC_010612.1 4923912 4925726 R PPE family protein complement(4923912..4925726) Mycobacterium marinum M 6228264 YP_001852253.1 CDS MMAR_3990 NC_010612.1 4925723 4926034 R PE-PGRS family protein complement(4925723..4926034) Mycobacterium marinum M 6228265 YP_001852254.1 CDS rsbU NC_010612.1 4927214 4929175 D may be involved in regulation of SigG; regulator of sigma subunit, anti-anti-sigma factor RsbU 4927214..4929175 Mycobacterium marinum M 6228266 YP_001852255.1 CDS MMAR_3992 NC_010612.1 4929188 4930423 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase complement(4929188..4930423) Mycobacterium marinum M 6228267 YP_001852256.1 CDS MMAR_3993 NC_010612.1 4930420 4931580 R function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase complement(4930420..4931580) Mycobacterium marinum M 6228268 YP_001852257.1 CDS MMAR_3994 NC_010612.1 4931749 4932573 D hypothetical protein 4931749..4932573 Mycobacterium marinum M 6228269 YP_001852258.1 CDS MMAR_3995 NC_010612.1 4932570 4933232 D hypothetical protein 4932570..4933232 Mycobacterium marinum M 6228270 YP_001852259.1 CDS cyp187A4 NC_010612.1 4933516 4934742 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 187A4 Cyp187A4 4933516..4934742 Mycobacterium marinum M 6228271 YP_001852260.1 CDS adhB_1 NC_010612.1 4934739 4935893 D thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD dependent AdhB 4934739..4935893 Mycobacterium marinum M 6228272 YP_001852261.1 CDS MMAR_3998 NC_010612.1 4935923 4936750 R function unknown, probably involved in cellular metabolism; short chain dehydrogenase complement(4935923..4936750) Mycobacterium marinum M 6228273 YP_001852262.1 CDS cyp108B4 NC_010612.1 4936856 4938088 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 108B4 Cyp108B4 complement(4936856..4938088) Mycobacterium marinum M 6228274 YP_001852263.1 CDS accD4_2 NC_010612.1 4938279 4939775 D key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.]; propionyl-CoA carboxylase beta chain 4 AccD4_2 4938279..4939775 Mycobacterium marinum M 6228275 YP_001852264.1 CDS MMAR_4001 NC_010612.1 4939765 4940421 R dehydrogenase/decarboxylase protein complement(4939765..4940421) Mycobacterium marinum M 6228276 YP_001852265.1 CDS MMAR_4002 NC_010612.1 4940442 4941335 R function unknown; contains full length of an uncharacterized homolog of a gamma-carboxymuconolactone decarboxylase subunit; dehydrogenase/decarboxylase protein complement(4940442..4941335) Mycobacterium marinum M 6228277 YP_001852266.1 CDS MMAR_4003 NC_010612.1 4941498 4942544 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(4941498..4942544) Mycobacterium marinum M 6228278 YP_001852267.1 CDS MMAR_4004 NC_010612.1 4942541 4942924 R function unknown but contains a Ntf2-like superfmaily domain; hypothetical protein complement(4942541..4942924) Mycobacterium marinum M 6228279 YP_001852268.1 CDS MMAR_4005 NC_010612.1 4942921 4943157 R hypothetical protein complement(4942921..4943157) Mycobacterium marinum M 6228280 YP_001852269.1 CDS MMAR_4006 NC_010612.1 4943288 4943905 D function unknown but contains thioesterase/thiol ester dehydrase-isomerase superfmaily domain; hypothetical protein 4943288..4943905 Mycobacterium marinum M 6228281 YP_001852270.1 CDS fadD19_2 NC_010612.1 4943993 4945636 D activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 4943993..4945636 Mycobacterium marinum M 6228282 YP_001852271.1 CDS cyp187A5 NC_010612.1 4945715 4946929 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 187A5 Cyp187A5 4945715..4946929 Mycobacterium marinum M 6228283 YP_001852272.1 CDS MMAR_4009 NC_010612.1 4946938 4948152 D dehydratase 4946938..4948152 Mycobacterium marinum M 6228284 YP_001852273.1 CDS MMAR_4010 NC_010612.1 4948174 4949355 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase complement(4948174..4949355) Mycobacterium marinum M 6228285 YP_001852274.1 CDS MMAR_4011 NC_010612.1 4949370 4950434 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase complement(4949370..4950434) Mycobacterium marinum M 6228286 YP_001852275.1 CDS MMAR_4012 NC_010612.1 4950431 4951267 R metal-dependent hydrolase complement(4950431..4951267) Mycobacterium marinum M 6228287 YP_001852276.1 CDS MMAR_4013 NC_010612.1 4951264 4952904 R activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase complement(4951264..4952904) Mycobacterium marinum M 6228288 YP_001852277.1 CDS MMAR_4014 NC_010612.1 4952918 4954123 R metal-dependent hydrolase complement(4952918..4954123) Mycobacterium marinum M 6228289 YP_001852278.1 CDS echA12_1 NC_010612.1 4954152 4954988 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(4954152..4954988) Mycobacterium marinum M 6228290 YP_001852279.1 CDS MMAR_4017 NC_010612.1 4956085 4956729 R hypothetical protein complement(4956085..4956729) Mycobacterium marinum M 6228292 YP_001852280.1 CDS MMAR_4018 NC_010612.1 4956950 4957279 D hypothetical protein 4956950..4957279 Mycobacterium marinum M 6228293 YP_001852281.1 CDS MMAR_4019 NC_010612.1 4957684 4958487 D involved in transcriptional mechanism; transcriptional regulatory protein 4957684..4958487 Mycobacterium marinum M 6228294 YP_001852282.1 CDS echA4_2 NC_010612.1 4958500 4959396 R oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA4_2 complement(4958500..4959396) Mycobacterium marinum M 6228295 YP_001852283.1 CDS MMAR_4021 NC_010612.1 4959393 4960067 R hypothetical protein complement(4959393..4960067) Mycobacterium marinum M 6228296 YP_001852284.1 CDS echA10_1 NC_010612.1 4960187 4961005 D oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA10 4960187..4961005 Mycobacterium marinum M 6228297 YP_001852285.1 CDS echA11_1 NC_010612.1 4961008 4961820 D oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA11 4961008..4961820 Mycobacterium marinum M 6228298 YP_001852286.1 CDS echA16_1 NC_010612.1 4961817 4962626 D oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA16 4961817..4962626 Mycobacterium marinum M 6228299 YP_001852287.1 CDS MMAR_4025 NC_010612.1 4962626 4964107 D function unknown, but supposed involvement in lipid degradation; long-chain fatty-acid CoA ligase 4962626..4964107 Mycobacterium marinum M 6228300 YP_001852288.1 CDS fadD35_1 NC_010612.1 4964097 4965695 D involved in lipid degradation; fatty-acid-CoA ligase FadD35 4964097..4965695 Mycobacterium marinum M 6228301 YP_001852289.1 CDS MMAR_4027 NC_010612.1 4965688 4967214 D function unknown, but involved in lipid degradation; fatty-acid-CoA ligase 4965688..4967214 Mycobacterium marinum M 6228302 YP_001852290.1 CDS MMAR_4028 NC_010612.1 4967531 4967896 R hypothetical protein complement(4967531..4967896) Mycobacterium marinum M 6228303 YP_001852291.1 CDS MMAR_4029 NC_010612.1 4968097 4968810 R possibly involved in transcriptional mechanism; GntR family transcriptional regulator complement(4968097..4968810) Mycobacterium marinum M 6228304 YP_001852292.1 CDS MMAR_4030 NC_010612.1 4968824 4970017 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase complement(4968824..4970017) Mycobacterium marinum M 6228305 YP_001852293.1 CDS MMAR_4031 NC_010612.1 4970014 4971243 R function unknown, but supposed involvement in lipid degradation; acyl-CoA transferase/carnitine dehydratase complement(4970014..4971243) Mycobacterium marinum M 6228306 YP_001852294.1 CDS MMAR_4032 NC_010612.1 4971246 4972469 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(4971246..4972469) Mycobacterium marinum M 6228307 YP_001852295.1 CDS fabG NC_010612.1 4972466 4973212 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(4972466..4973212) Mycobacterium marinum M 6228308 YP_001852296.1 CDS fadE NC_010612.1 4973331 4974494 D function unknown, but involved in lipid metabolism [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]; acyl-CoA dehydrogenase FadE 4973331..4974494 Mycobacterium marinum M 6228309 YP_001852297.1 CDS MMAR_4035 NC_010612.1 4974497 4975564 R function unknown but contains a protein-kinase superfamily domain; hypothetical protein complement(4974497..4975564) Mycobacterium marinum M 6228310 YP_001852298.1 CDS MMAR_4036 NC_010612.1 4975618 4977357 R thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein complement(4975618..4977357) Mycobacterium marinum M 6228311 YP_001852299.1 CDS MMAR_4037 NC_010612.1 4977354 4979978 R thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein complement(4977354..4979978) Mycobacterium marinum M 6228312 YP_001852300.1 CDS lprD NC_010612.1 4980715 4981107 D lipoprotein LprD 4980715..4981107 Mycobacterium marinum M 6228314 YP_001852301.1 CDS MMAR_4039 NC_010612.1 4981104 4981466 D hypothetical protein 4981104..4981466 Mycobacterium marinum M 6228315 YP_001852302.1 CDS MMAR_4040 NC_010612.1 4981491 4982102 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase complement(4981491..4982102) Mycobacterium marinum M 6228316 YP_001852303.1 CDS MMAR_4041 NC_010612.1 4982258 4982800 R hypothetical protein complement(4982258..4982800) Mycobacterium marinum M 6228317 YP_001852304.1 CDS rph NC_010612.1 4983081 4983911 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(4983081..4983911) Mycobacterium marinum M 6228318 YP_001852305.1 CDS MMAR_4043 NC_010612.1 4983962 4984729 R metal-dependent hydrolase complement(4983962..4984729) Mycobacterium marinum M 6228319 YP_001852306.1 CDS MMAR_4044 NC_010612.1 4984735 4984914 R hypothetical protein complement(4984735..4984914) Mycobacterium marinum M 6228320 YP_001852307.1 CDS MMAR_4045 NC_010612.1 4985113 4985844 D hypothetical protein 4985113..4985844 Mycobacterium marinum M 6228321 YP_001852308.1 CDS aceE_1 NC_010612.1 4986111 4988438 R involved in energy metabolism; contributes to acetyl-CoA production as part of pyruvate dehydrogenase complex [catalytic activity: pyruvate + lipoamide = S- acetyl-dihydro-lipoamide + CO(2)]; pyruvate dehydrogenase E1 component AceE complement(4986111..4988438) Mycobacterium marinum M 6228322 YP_001852309.1 CDS MMAR_4047 NC_010612.1 4988577 4989065 D involved in transcriptional mechanism; Lrp/AsnC family transcriptional regulator 4988577..4989065 Mycobacterium marinum M 6228323 YP_001852310.1 CDS MMAR_4048 NC_010612.1 4989432 4989932 D hypothetical protein 4989432..4989932 Mycobacterium marinum M 6228324 YP_001852311.1 CDS yrbE3A_1 NC_010612.1 4990695 4991462 D integral membrane protein YrbE3A 4990695..4991462 Mycobacterium marinum M 6228325 YP_001852312.1 CDS yrbE3B_1 NC_010612.1 4991459 4992313 D integral membrane protein YrbE3B 4991459..4992313 Mycobacterium marinum M 6228326 YP_001852313.1 CDS mce3A_1 NC_010612.1 4992318 4993778 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3A 4992318..4993778 Mycobacterium marinum M 6228327 YP_001852314.1 CDS mce3B_1 NC_010612.1 4993858 4994889 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3B 4993858..4994889 Mycobacterium marinum M 6228328 YP_001852315.1 CDS mce3C_1 NC_010612.1 4994886 4996202 D function unknown, but thought to be involved in host cell invasion; MCE-family protein, Mce3C 4994886..4996202 Mycobacterium marinum M 6228329 YP_001852316.1 CDS mce3D_1 NC_010612.1 4996199 4997545 D function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3D 4996199..4997545 Mycobacterium marinum M 6228330 YP_001852317.1 CDS lprM_1 NC_010612.1 4997542 4998687 D function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein LprM 4997542..4998687 Mycobacterium marinum M 6228331 YP_001852318.1 CDS mce3F_1 NC_010612.1 4998689 5000146 D function unknown, but thought involved in host cell invasion; MCE-family protein Mce3F 4998689..5000146 Mycobacterium marinum M 6228332 YP_001852319.1 CDS MMAR_4057 NC_010612.1 5000143 5000856 D Mce associated membrane protein 5000143..5000856 Mycobacterium marinum M 6228333 YP_001852320.1 CDS murI NC_010612.1 5000899 5001714 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(5000899..5001714) Mycobacterium marinum M 6228334 YP_001852321.1 CDS MMAR_4059 NC_010612.1 5001711 5002379 R function unknown; contains a C-term rhomboid-family domain. these proteins contain three strongly conserved histidines in the putative transmembrane regions that may be involved in peptidase functions; integral membrane protein complement(5001711..5002379) Mycobacterium marinum M 6228335 YP_001852322.1 CDS MMAR_4060 NC_010612.1 5002902 5003201 D hypothetical protein 5002902..5003201 Mycobacterium marinum M 6228336 YP_001852323.1 CDS MMAR_4061 NC_010612.1 5003202 5004212 D hypothetical protein 5003202..5004212 Mycobacterium marinum M 6228337 YP_001852324.1 CDS MMAR_4062 NC_010612.1 5004217 5004636 D function unknown; contains signal peptide; hypothetical protein 5004217..5004636 Mycobacterium marinum M 6228338 YP_001852325.1 CDS cfp10A NC_010612.1 5004830 5005102 R putative antigen Cfp10A complement(5004830..5005102) Mycobacterium marinum M 6228339 YP_001852326.1 CDS MMAR_4064 NC_010612.1 5005124 5005537 R function unknown but domain identity suggests this CDS encodes a metal-dependent protease of the Pad1/Jab1 superfamily; hypothetical protein complement(5005124..5005537) Mycobacterium marinum M 6228340 YP_001852327.1 CDS dmpA NC_010612.1 5005539 5006627 R function unknown, probable role in amino acid hydrolysis; L-aminopeptidase/D-esterase DmpA complement(5005539..5006627) Mycobacterium marinum M 6228341 YP_001852328.1 CDS MMAR_4066 NC_010612.1 5006624 5007211 R hypothetical protein complement(5006624..5007211) Mycobacterium marinum M 6228342 YP_001852329.1 CDS MMAR_4067 NC_010612.1 5007236 5007541 R function unknown but contains a ClpS domain suggesting a function related to ATP-dependent protein degradation; hypothetical protein complement(5007236..5007541) Mycobacterium marinum M 6228343 YP_001852330.1 CDS pncB NC_010612.1 5007607 5008923 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 5007607..5008923 Mycobacterium marinum M 6228344 YP_001852331.1 CDS dinG NC_010612.1 5008959 5010980 D probable helicase involved in DNA repair and perhaps also replication; ATP-dependent helicase DinG 5008959..5010980 Mycobacterium marinum M 6228345 YP_001852332.1 CDS glgP NC_010612.1 5010977 5013568 R catalytic activity : {(1,4)-alpha-D-glucosyl}(N) + phosphate = {(1,4)-alpha-D-glucosyl}(N-1) + alpha-D- glucose 1-phosphate; glycogen phosphorylase GlgP complement(5010977..5013568) Mycobacterium marinum M 6228346 YP_001852333.1 CDS MMAR_4071 NC_010612.1 5013758 5015845 D function unknown, may be involved in polysaccharide degradation; glycosidase 5013758..5015845 Mycobacterium marinum M 6228347 YP_001852334.1 CDS glgB NC_010612.1 5015852 5018047 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 5015852..5018047 Mycobacterium marinum M 6228348 YP_001852335.1 CDS MMAR_4073 NC_010612.1 5018058 5019029 R transposition of ISMyma04; transposase for ISMyma04 complement(5018058..5019029) Mycobacterium marinum M 6228349 YP_001852336.1 CDS MMAR_4074 NC_010612.1 5019205 5020119 R thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin complement(5019205..5020119) Mycobacterium marinum M 6228350 YP_001852337.1 CDS fadA4 NC_010612.1 5020297 5021478 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(5020297..5021478) Mycobacterium marinum M 6228351 YP_001852338.1 CDS gloA_1 NC_010612.1 5021561 5022028 D glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway; glyoxalase GloA 5021561..5022028 Mycobacterium marinum M 6228352 YP_001852339.1 CDS MMAR_4077 NC_010612.1 5022341 5023012 R function unknown but contains a predicted nuclease domain of the RecB family; hypothetical protein complement(5022341..5023012) Mycobacterium marinum M 6228353 YP_001852340.1 CDS MMAR_4078 NC_010612.1 5023058 5024710 D thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 5023058..5024710 Mycobacterium marinum M 6228354 YP_001852341.1 CDS MMAR_4079 NC_010612.1 5024855 5026459 D thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 5024855..5026459 Mycobacterium marinum M 6228355 YP_001852342.1 CDS MMAR_4080 NC_010612.1 5026591 5028210 D thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 5026591..5028210 Mycobacterium marinum M 6228356 YP_001852343.1 CDS alkA NC_010612.1 5028263 5029780 D involved in damage reversal and in base excision repair. the methylated Ada protein acts as a positive regulator of its own synthesis, as well as that of other proteins. the transcription-activating function of the Ada protein resides in its N-terminus. repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated. can also repair O-4- methylthymine [catalytic activity: DNA (containing 6-O- methylguanine) + [protein]-L-cysteine = DNA (without 6-O- methylguanine) + protein S-methyl-L-cysteine]; Ada regulatory protein AlkA 5028263..5029780 Mycobacterium marinum M 6228357 YP_001852344.1 CDS ogt NC_010612.1 5029777 5030295 D repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated [catalytic activity : DNA (containing 6-O-methylguanine) + [protein]-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.]; methylated-DNA--protein-cysteine methyltransferase Ogt 5029777..5030295 Mycobacterium marinum M 6228358 YP_001852345.1 CDS murA NC_010612.1 5035745 5036998 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(5035745..5036998) Mycobacterium marinum M 6228362 YP_001852346.1 CDS MMAR_4084 NC_010612.1 5037069 5037662 D these proteins convert inactive cobalamins to AdoCbl for 1,2-propanediol degradation; cobalamin adenosyltransferase 5037069..5037662 Mycobacterium marinum M 6228363 YP_001852347.1 CDS MMAR_4085 NC_010612.1 5037753 5038196 R hypothetical protein complement(5037753..5038196) Mycobacterium marinum M 6228364 YP_001852348.1 CDS atpC NC_010612.1 5038204 5038569 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(5038204..5038569) Mycobacterium marinum M 6228365 YP_001852349.1 CDS atpD NC_010612.1 5038606 5040057 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(5038606..5040057) Mycobacterium marinum M 6228366 YP_001852350.1 CDS atpG NC_010612.1 5040086 5041000 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(5040086..5041000) Mycobacterium marinum M 6228367 YP_001852351.1 CDS atpA NC_010612.1 5041019 5042668 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(5041019..5042668) Mycobacterium marinum M 6228368 YP_001852352.1 CDS atpH NC_010612.1 5042730 5044067 R produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(5042730..5044067) Mycobacterium marinum M 6228369 YP_001852353.1 CDS atpF NC_010612.1 5044074 5044586 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(5044074..5044586) Mycobacterium marinum M 6228370 YP_001852354.1 CDS atpE NC_010612.1 5044628 5044873 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(5044628..5044873) Mycobacterium marinum M 6228371 YP_001852355.1 CDS atpB NC_010612.1 5044964 5045716 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(5044964..5045716) Mycobacterium marinum M 6228372 YP_001852356.1 CDS MMAR_4094 NC_010612.1 5045709 5046209 R hypothetical protein complement(5045709..5046209) Mycobacterium marinum M 6228373 YP_001852357.1 CDS rfe NC_010612.1 5046460 5047638 R catalysis of the first step of the lipid cycle reactions in the biosynthesis of cell wall peptidoglycan; undecapaprenyl-phosphate alpha-N- acetylglucosaminyltransferase Rfe complement(5046460..5047638) Mycobacterium marinum M 6228374 YP_001852358.1 CDS MMAR_4096 NC_010612.1 5047720 5048370 R function unknown but contains YrdC domain. this domain has been shown to preferentially bind to dsRNA; hypothetical protein complement(5047720..5048370) Mycobacterium marinum M 6228375 YP_001852359.1 CDS hemK NC_010612.1 5048423 5049271 R function unknown but may have S-adenosyl-methionine- dependent methyltransferase activity; modification methylase HemK complement(5048423..5049271) Mycobacterium marinum M 6228376 YP_001852360.1 CDS prfA NC_010612.1 5049268 5050341 R recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 complement(5049268..5050341) Mycobacterium marinum M 6228377 YP_001852361.1 CDS rpmE NC_010612.1 5050429 5050674 R RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(5050429..5050674) Mycobacterium marinum M 6228378 YP_001852362.1 CDS rho NC_010612.1 5050866 5052731 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(5050866..5052731) Mycobacterium marinum M 6228379 YP_001852363.1 CDS thrB NC_010612.1 5052998 5053942 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(5052998..5053942) Mycobacterium marinum M 6228380 YP_001852364.1 CDS thrC NC_010612.1 5053998 5055080 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(5053998..5055080) Mycobacterium marinum M 6228381 YP_001852365.1 CDS thrA NC_010612.1 5055077 5056402 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(5055077..5056402) Mycobacterium marinum M 6228382 YP_001852366.1 CDS lysA NC_010612.1 5056406 5057824 R involved in biosynthesis of lysine (last step) [catalytic activity : meso-2,6-diaminoheptanedioate = L- lysine + CO(2)]; diaminopimelate decarboxylase LysA complement(5056406..5057824) Mycobacterium marinum M 6228383 YP_001852367.1 CDS argS NC_010612.1 5057821 5059473 R catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase complement(5057821..5059473) Mycobacterium marinum M 6228384 YP_001852368.1 CDS MMAR_4106 NC_010612.1 5059968 5061524 D transposition of ISMyma05; transposase for ISMyma05 5059968..5061524 Mycobacterium marinum M 6228386 YP_001852369.1 CDS MMAR_4107 NC_010612.1 5062415 5062711 D hypothetical protein 5062415..5062711 Mycobacterium marinum M 6228387 YP_001852370.1 CDS MMAR_5576 NC_010612.1 5063642 5063917 D hypothetical protein 5063642..5063917 Mycobacterium marinum M 6228389 YP_001852371.1 CDS MMAR_4109 NC_010612.1 5064070 5064588 R PE-PGRS family protein complement(5064070..5064588) Mycobacterium marinum M 6228390 YP_001852372.1 CDS MMAR_4110 NC_010612.1 5065092 5067761 D this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 5065092..5067761 Mycobacterium marinum M 6228391 YP_001852373.1 CDS MMAR_4111 NC_010612.1 5067727 5068134 R pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate; pyridoxamine 5'-phosphate oxidase complement(5067727..5068134) Mycobacterium marinum M 6228392 YP_001852374.1 CDS MMAR_4112 NC_010612.1 5068200 5068559 R function unknown but contains YCII-related protein domain; hypothetical protein complement(5068200..5068559) Mycobacterium marinum M 6228393 YP_001852375.1 CDS dhaA NC_010612.1 5068552 5069424 R catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase complement(5068552..5069424) Mycobacterium marinum M 6228394 YP_001852376.1 CDS MMAR_5521 NC_010612.1 5069475 5071265 R cleaves xaa-pro-releasing N-terminal dipeptides; peptidase S15 complement(5069475..5071265) Mycobacterium marinum M 6228395 YP_001852377.1 CDS MMAR_4115 NC_010612.1 5071407 5072054 D function unknown but belongs to the TetR family of bacterial transcriptional regulatory proteins; putative regulatory protein 5071407..5072054 Mycobacterium marinum M 6228396 YP_001852378.1 CDS MMAR_4116 NC_010612.1 5072064 5072576 R PE-PGRS family protein complement(5072064..5072576) Mycobacterium marinum M 6228397 YP_001852379.1 CDS MMAR_4117 NC_010612.1 5072707 5073612 R function unknown, belongs to the LysR family of transcriptional regulators; putative regulatory protein complement(5072707..5073612) Mycobacterium marinum M 6228398 YP_001852380.1 CDS MMAR_4118 NC_010612.1 5073703 5075031 D function unknown role in transport. belongs to the DMT superfamily; membrane permease 5073703..5075031 Mycobacterium marinum M 6228399 YP_001852381.1 CDS MMAR_4119 NC_010612.1 5074916 5075560 D hypothetical protein 5074916..5075560 Mycobacterium marinum M 6228400 YP_001852382.1 CDS MMAR_4120 NC_010612.1 5075758 5077341 D thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 5075758..5077341 Mycobacterium marinum M 6228401 YP_001852383.1 CDS MMAR_4121 NC_010612.1 5077507 5077848 D hypothetical protein 5077507..5077848 Mycobacterium marinum M 6228402 YP_001852384.1 CDS MMAR_4122 NC_010612.1 5078080 5079558 D hypothetical protein 5078080..5079558 Mycobacterium marinum M 6228403 YP_001852385.1 CDS MMAR_4123 NC_010612.1 5079599 5080225 R hypothetical protein complement(5079599..5080225) Mycobacterium marinum M 6228404 YP_001852386.1 CDS MMAR_4124 NC_010612.1 5080318 5080845 R hypothetical protein complement(5080318..5080845) Mycobacterium marinum M 6228405 YP_001852387.1 CDS MMAR_4125 NC_010612.1 5080996 5081532 R NUDIX hydrolases catalyze the hydrolysis of a variety of nucleoside diphoshate derivatives; NUDIX hydrolase complement(5080996..5081532) Mycobacterium marinum M 6228406 YP_001852388.1 CDS MMAR_4126 NC_010612.1 5081791 5083542 D function unknown but contains TrkA domain. this domain is found in a wide variety of proteins. these protein include potassium channels P31069, phosphoesterases Q59027, and various other transporters. this domain binds to NAD; putative transport protein 5081791..5083542 Mycobacterium marinum M 6228407 YP_001852389.1 CDS MMAR_4127 NC_010612.1 5083551 5084954 R PE-PGRS family protein complement(5083551..5084954) Mycobacterium marinum M 6228408 YP_001852390.1 CDS MMAR_4128 NC_010612.1 5085052 5085939 R function unknown, probably involved in cellular metabolism; flavin-dependent oxidoreductase complement(5085052..5085939) Mycobacterium marinum M 6228409 YP_001852391.1 CDS gloA_2 NC_010612.1 5085979 5086392 D catalyzes the first step of the glyoxal pathway; glyoxalase GloA 5085979..5086392 Mycobacterium marinum M 6228410 YP_001852392.1 CDS MMAR_4130 NC_010612.1 5086485 5086874 D function unknown but contains glyoxalase/bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily domain; hypothetical protein 5086485..5086874 Mycobacterium marinum M 6228411 YP_001852393.1 CDS MMAR_4131 NC_010612.1 5086871 5087356 R putative transcriptional regulatory protein complement(5086871..5087356) Mycobacterium marinum M 6228412 YP_001852394.1 CDS cysN NC_010612.1 5087450 5089300 R in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase complement(5087450..5089300) Mycobacterium marinum M 6228413 YP_001852395.1 CDS cysD NC_010612.1 5089300 5090232 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(5089300..5090232) Mycobacterium marinum M 6228414 YP_001852396.1 CDS MMAR_4134 NC_010612.1 5090420 5090854 D function unknown, contains a thioesterase superfamily domain; hypothetical protein 5090420..5090854 Mycobacterium marinum M 6228415 YP_001852397.1 CDS MMAR_4135 NC_010612.1 5090862 5091353 R domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide; carbonic anhydrase complement(5090862..5091353) Mycobacterium marinum M 6228416 YP_001852398.1 CDS oppB NC_010612.1 5091676 5092653 D involved in active transport of oligopeptide across the membrane (import). responsible for the translocation of the substrate across the membrane; oligopeptide-transport integral membrane protein ABC transporter OppB 5091676..5092653 Mycobacterium marinum M 6228417 YP_001852399.1 CDS oppC NC_010612.1 5092650 5093543 D involved in active transport of oligopeptide across the membrane (import). responsible for the translocation of the substrate across the membrane; oligopeptide-transport integral membrane protein ABC transporter OppC 5092650..5093543 Mycobacterium marinum M 6228418 YP_001852400.1 CDS oppD NC_010612.1 5093540 5095378 D involved in active transport of oligopeptide across the membrane (import). responsible for energy coupling to the transport system; oligopeptide-transport ATP-binding protein ABC transporter OppD 5093540..5095378 Mycobacterium marinum M 6228419 YP_001852401.1 CDS oppA NC_010612.1 5095368 5097116 D involved in active transport of oligopeptide across the membrane (import). this protein is a component of the oligopeptide permease, a binding protein-dependent transport system; it binds peptides up to five amino acids long with high affinity; periplasmic oligopeptide-binding lipoprotein OppA 5095368..5097116 Mycobacterium marinum M 6228420 YP_001852402.1 CDS MMAR_4140 NC_010612.1 5097103 5098353 R function unknown but contains alpha/beta-hydrolase superfamily domain; hydrolase complement(5097103..5098353) Mycobacterium marinum M 6228421 YP_001852403.1 CDS MMAR_4141 NC_010612.1 5098443 5100032 R function unknown, probably involved in cellular metabolism, probably electron-transfer-linked; dehydrogenase fad flavoprotein GMC oxidoreductase complement(5098443..5100032) Mycobacterium marinum M 6228422 YP_001852404.1 CDS MMAR_4142 NC_010612.1 5100082 5102712 R function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain; hydrolase complement(5100082..5102712) Mycobacterium marinum M 6228423 YP_001852405.1 CDS sbcD NC_010612.1 5102709 5103860 R function unknown: possible role in DNA replication, recombination, and repair; DNA repair exonuclease SbcD complement(5102709..5103860) Mycobacterium marinum M 6228424 YP_001852406.1 CDS sixA NC_010612.1 5104146 5104649 D function unknown, possible role in signal transduction; phosphohistidine phosphatase SixA 5104146..5104649 Mycobacterium marinum M 6228425 YP_001852407.1 CDS lprC NC_010612.1 5104709 5105287 R lipoprotein LprC complement(5104709..5105287) Mycobacterium marinum M 6228426 YP_001852408.1 CDS lprB NC_010612.1 5105284 5105841 R lipoprotein LprB complement(5105284..5105841) Mycobacterium marinum M 6228427 YP_001852409.1 CDS MMAR_4147 NC_010612.1 5105989 5107728 D thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 5105989..5107728 Mycobacterium marinum M 6228428 YP_001852410.1 CDS MMAR_4148 NC_010612.1 5107725 5109647 D thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 5107725..5109647 Mycobacterium marinum M 6228429 YP_001852411.1 CDS MMAR_4149 NC_010612.1 5109713 5111515 R PE-PGRS family protein complement(5109713..5111515) Mycobacterium marinum M 6228430 YP_001852412.1 CDS MMAR_4150 NC_010612.1 5112236 5112568 D hypothetical protein 5112236..5112568 Mycobacterium marinum M 6228431 YP_001852413.1 CDS MMAR_4151 NC_010612.1 5112800 5113132 D hypothetical protein 5112800..5113132 Mycobacterium marinum M 6228432 YP_001852414.1 CDS lprA NC_010612.1 5113372 5114112 D lipoprotein LprA 5113372..5114112 Mycobacterium marinum M 6228433 YP_001852415.1 CDS MMAR_4153 NC_010612.1 5114196 5114564 D hypothetical protein 5114196..5114564 Mycobacterium marinum M 6228434 YP_001852416.1 CDS MMAR_4154 NC_010612.1 5114708 5115418 D hypothetical protein 5114708..5115418 Mycobacterium marinum M 6228435 YP_001852417.1 CDS embR NC_010612.1 5115755 5116915 D involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB; transcriptional regulatory protein EmbR 5115755..5116915 Mycobacterium marinum M 6228436 YP_001852418.1 CDS pknH NC_010612.1 5117268 5119058 D involved in signal transduction (via phosphorylation). in M. tuberculosis thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 5117268..5119058 Mycobacterium marinum M 6228437 YP_001852419.1 CDS MMAR_4157 NC_010612.1 5119449 5120351 R LuxR family transcriptional regulator complement(5119449..5120351) Mycobacterium marinum M 6228438 YP_001852420.1 CDS citE_1 NC_010612.1 5120457 5121305 D interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate (pro-3S)-lyase subunit beta 5120457..5121305 Mycobacterium marinum M 6228439 YP_001852421.1 CDS MMAR_4159 NC_010612.1 5121293 5121820 D dehydratase 5121293..5121820 Mycobacterium marinum M 6228440 YP_001852422.1 CDS MMAR_4160 NC_010612.1 5121820 5123157 D could be implicated in several pathways involving acetyl-CoA. E.G. acetyl-CoA hydrolase from yeast catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) produces succinyl-CoA, and acetate-CoA transferase utilizes acyl-CoA and acetate to form acetyl-CoA; acetyl-CoA hydrolase/transferase 5121820..5123157 Mycobacterium marinum M 6228441 YP_001852423.1 CDS fadE3 NC_010612.1 5123175 5124350 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE3 5123175..5124350 Mycobacterium marinum M 6228442 YP_001852424.1 CDS gdpD NC_010612.1 5124382 5125290 R hydrolyses glycerophosphodiesters such as glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol); glycerolphosphodiesterase GdpD complement(5124382..5125290) Mycobacterium marinum M 6228443 YP_001852425.1 CDS MMAR_4163 NC_010612.1 5125483 5125908 R hypothetical protein complement(5125483..5125908) Mycobacterium marinum M 6228444 YP_001852426.1 CDS MMAR_4164 NC_010612.1 5125980 5126612 D hypothetical protein 5125980..5126612 Mycobacterium marinum M 6228445 YP_001852427.1 CDS gloA_3 NC_010612.1 5126681 5127100 R glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway; glyoxalase GloA complement(5126681..5127100) Mycobacterium marinum M 6228446 YP_001852428.1 CDS espA NC_010612.1 5128562 5129731 D ESX-1 secretion-associated protein A, EspA 5128562..5129731 Mycobacterium marinum M 6228447 YP_001852429.1 CDS MMAR_4167 NC_010612.1 5129792 5130103 D hypothetical protein 5129792..5130103 Mycobacterium marinum M 6228448 YP_001852430.1 CDS MMAR_4168 NC_010612.1 5130117 5130788 D hypothetical protein 5130117..5130788 Mycobacterium marinum M 6228449 YP_001852431.1 CDS pknH_1 NC_010612.1 5130970 5132823 D involved in signal transduction (via phosphorylation) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 5130970..5132823 Mycobacterium marinum M 6228450 YP_001852432.1 CDS MMAR_4170 NC_010612.1 5132869 5135241 D thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 5132869..5135241 Mycobacterium marinum M 6228451 YP_001852433.1 CDS MMAR_4171 NC_010612.1 5135676 5137679 D involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 5135676..5137679 Mycobacterium marinum M 6228452 YP_001852434.1 CDS MMAR_4172 NC_010612.1 5137691 5138278 R function unknown. seems to be expressed during macrophage infection; hypothetical protein complement(5137691..5138278) Mycobacterium marinum M 6228453 YP_001852435.1 CDS MMAR_4173 NC_010612.1 5138569 5139750 R possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; adenylate cyclase complement(5138569..5139750) Mycobacterium marinum M 6228454 YP_001852436.1 CDS pknF NC_010612.1 5139850 5141337 D involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; anchored-membrane serine/threonine-protein kinase PknF 5139850..5141337 Mycobacterium marinum M 6228455 YP_001852437.1 CDS MMAR_4175 NC_010612.1 5141334 5141867 D hypothetical protein 5141334..5141867 Mycobacterium marinum M 6228456 YP_001852438.1 CDS amiB2 NC_010612.1 5141881 5143269 R catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase complement(5141881..5143269) Mycobacterium marinum M 6228457 YP_001852439.1 CDS MMAR_4177 NC_010612.1 5143372 5143800 D Hit-like protein 5143372..5143800 Mycobacterium marinum M 6228458 YP_001852440.1 CDS MMAR_4178 NC_010612.1 5143811 5144263 D hypothetical protein 5143811..5144263 Mycobacterium marinum M 6228459 YP_001852441.1 CDS MMAR_4179 NC_010612.1 5144272 5145315 R monooxygenase complement(5144272..5145315) Mycobacterium marinum M 6228460 YP_001852442.1 CDS MMAR_4180 NC_010612.1 5145362 5146498 R function unknown, probably involved in cellular metabolism; hypothetical protein complement(5145362..5146498) Mycobacterium marinum M 6228461 YP_001852443.1 CDS MMAR_4181 NC_010612.1 5146502 5147329 R hypothetical protein complement(5146502..5147329) Mycobacterium marinum M 6228462 YP_001852444.1 CDS MMAR_4182 NC_010612.1 5147401 5148654 D thought to be involved in transport of undeterminated substrate (possibly macrolide) across the membrane (export). responsible for the translocation of the undeterminated substrate across the membrane; hypothetical protein 5147401..5148654 Mycobacterium marinum M 6228463 YP_001852445.1 CDS MMAR_4183 NC_010612.1 5148712 5150079 D function unknown, probably involved in cellular metabolism; oxidoreductase 5148712..5150079 Mycobacterium marinum M 6228464 YP_001852446.1 CDS cyp130A4 NC_010612.1 5150285 5151526 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 130A4 Cyp130A4 5150285..5151526 Mycobacterium marinum M 6228465 YP_001852447.1 CDS MMAR_4185 NC_010612.1 5151526 5152107 D involved in transcriptional mechanism; transcriptional regulatory protein 5151526..5152107 Mycobacterium marinum M 6228466 YP_001852448.1 CDS MMAR_4186 NC_010612.1 5152623 5154674 D PE-PGRS family protein 5152623..5154674 Mycobacterium marinum M 6228467 YP_001852449.1 CDS MMAR_5552 NC_010612.1 5154828 5154980 R hypothetical protein complement(5154828..5154980) Mycobacterium marinum M 6228468 YP_001852450.1 CDS MMAR_4187 NC_010612.1 5155313 5156086 D PPE family protein 5155313..5156086 Mycobacterium marinum M 6228469 YP_001852451.1 CDS MMAR_4188 NC_010612.1 5156177 5157319 R catalyzes the acylation of the mycaminose sugar during midecamycin biosynthesis; integral membrane acyltransferase complement(5156177..5157319) Mycobacterium marinum M 6228470 YP_001852452.1 CDS deaD NC_010612.1 5157316 5159031 R has a helix-destabilizing activity; cold-shock DEAD-box protein, DeaD complement(5157316..5159031) Mycobacterium marinum M 6228471 YP_001852453.1 CDS lprE NC_010612.1 5159599 5160195 D lipoprotein LprE 5159599..5160195 Mycobacterium marinum M 6228472 YP_001852454.1 CDS MMAR_4191 NC_010612.1 5160269 5163685 D hypothetical protein 5160269..5163685 Mycobacterium marinum M 6228473 YP_001852455.1 CDS MMAR_4192 NC_010612.1 5163694 5165574 R thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; drug-transport integral membrane protein complement(5163694..5165574) Mycobacterium marinum M 6228474 YP_001852456.1 CDS MMAR_4193 NC_010612.1 5165787 5166545 D hypothetical protein 5165787..5166545 Mycobacterium marinum M 6228475 YP_001852457.1 CDS kgd NC_010612.1 5166708 5170463 D kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 5166708..5170463 Mycobacterium marinum M 6228476 YP_001852458.1 CDS MMAR_4195 NC_010612.1 5170620 5171453 D function unknown, supposed involved in cellular metabolism; short-chain type dehydrogenase/reductase 5170620..5171453 Mycobacterium marinum M 6228477 YP_001852459.1 CDS lpqZ NC_010612.1 5171490 5172341 R lipoprotein LpqZ complement(5171490..5172341) Mycobacterium marinum M 6228478 YP_001852460.1 CDS mez_1 NC_010612.1 5172353 5173567 R catalizes the oxidative decarboxylation of malate into pyruvate, important for a wide range of metabolic pathways [catalytic activity: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH]; [NAD] dependent malate oxidoreductase Mez complement(5172353..5173567) Mycobacterium marinum M 6228479 YP_001852461.1 CDS mdh NC_010612.1 5173726 5174715 R catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase complement(5173726..5174715) Mycobacterium marinum M 6228480 YP_001852462.1 CDS corA NC_010612.1 5174899 5175999 D thought to be involved in transport of magnesium and cobalt ions across the membrane. responsible for the translocation of the substrate across the membrane; magnesium and cobalt transport transmembrane protein CorA 5174899..5175999 Mycobacterium marinum M 6228481 YP_001852463.1 CDS fgd2 NC_010612.1 5176004 5177149 R catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor; F420-dependent glucose-6-phosphate dehydrogenase Fgd2 complement(5176004..5177149) Mycobacterium marinum M 6228482 YP_001852464.1 CDS gabP_1 NC_010612.1 5177391 5178836 R involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane; GabA permease GabP complement(5177391..5178836) Mycobacterium marinum M 6228483 YP_001852465.1 CDS MMAR_4202 NC_010612.1 5179118 5179711 R hypothetical protein complement(5179118..5179711) Mycobacterium marinum M 6228484 YP_001852466.1 CDS sugC NC_010612.1 5179708 5180895 R involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system; sugar-transport ATP-binding protein ABC transporter SugC complement(5179708..5180895) Mycobacterium marinum M 6228485 YP_001852467.1 CDS sugB NC_010612.1 5180900 5181730 R involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein ABC transporter SugB complement(5180900..5181730) Mycobacterium marinum M 6228486 YP_001852468.1 CDS sugA NC_010612.1 5181741 5182649 R involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein ABC transporter SugA complement(5181741..5182649) Mycobacterium marinum M 6228487 YP_001852469.1 CDS lpqY NC_010612.1 5182646 5184082 R thought to be involved in active transport of sugar across the membrane (import); sugar-binding lipoprotein LpqY complement(5182646..5184082) Mycobacterium marinum M 6228488 YP_001852470.1 CDS MMAR_4207 NC_010612.1 5184093 5184620 R hypothetical protein complement(5184093..5184620) Mycobacterium marinum M 6228489 YP_001852471.1 CDS MMAR_4208 NC_010612.1 5184862 5185530 D proline and glycine rich transmembrane protein 5184862..5185530 Mycobacterium marinum M 6228490 YP_001852472.1 CDS MMAR_4209 NC_010612.1 5185630 5186937 D thought to be involved in Mg2+ transport. responsible for the translocation of the substrate across the membrane; transport transmembrane protein 5185630..5186937 Mycobacterium marinum M 6228491 YP_001852473.1 CDS MMAR_4210 NC_010612.1 5186934 5187464 D hypothetical protein 5186934..5187464 Mycobacterium marinum M 6228492 YP_001852474.1 CDS MMAR_4211 NC_010612.1 5187583 5188956 D membrane protein 5187583..5188956 Mycobacterium marinum M 6228493 YP_001852475.1 CDS mrp NC_010612.1 5189008 5190168 D function unknown: thought to be an ATP-binding protein; Mrp-related protein Mrp 5189008..5190168 Mycobacterium marinum M 6228494 YP_001852476.1 CDS tatB NC_010612.1 5190184 5190549 R mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase complement(5190184..5190549) Mycobacterium marinum M 6228495 YP_001852477.1 CDS htrA NC_010612.1 5190576 5192090 R possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residue); serine protease HtrA (DegP protein) complement(5190576..5192090) Mycobacterium marinum M 6228496 YP_001852478.1 CDS MMAR_4215 NC_010612.1 5192262 5192666 R hypothetical protein complement(5192262..5192666) Mycobacterium marinum M 6228497 YP_001852479.1 CDS sigE NC_010612.1 5192812 5193579 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE complement(5192812..5193579) Mycobacterium marinum M 6228498 YP_001852480.1 CDS MMAR_4217 NC_010612.1 5193802 5194476 D function unknown, involved in cellular metabolism; methyltransferase 5193802..5194476 Mycobacterium marinum M 6228499 YP_001852481.1 CDS MMAR_4218 NC_010612.1 5194539 5196725 R PPE family protein complement(5194539..5196725) Mycobacterium marinum M 6228500 YP_001852482.1 CDS MMAR_4219 NC_010612.1 5196932 5197570 D involved in transcriptional mechanism; transcriptional regulator 5196932..5197570 Mycobacterium marinum M 6228501 YP_001852483.1 CDS MMAR_4220 NC_010612.1 5197560 5198507 D thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system; antibiotic ABC transporter ATP-binding protein 5197560..5198507 Mycobacterium marinum M 6228502 YP_001852484.1 CDS MMAR_4221 NC_010612.1 5198504 5200147 D thought to be involved in active transport of tetronasin across the membrane (export): tetronasin resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; tetronasin-transport integral membrane protein ABC transporter 5198504..5200147 Mycobacterium marinum M 6228503 YP_001852485.1 CDS MMAR_4222 NC_010612.1 5200176 5200850 D integral membrane protein 5200176..5200850 Mycobacterium marinum M 6228504 YP_001852486.1 CDS MMAR_4223 NC_010612.1 5201063 5202871 D PE-PGRS family protein 5201063..5202871 Mycobacterium marinum M 6228505 YP_001852487.1 CDS MMAR_4224 NC_010612.1 5203115 5204911 D PE-PGRS family protein 5203115..5204911 Mycobacterium marinum M 6228506 YP_001852488.1 CDS glgC NC_010612.1 5205003 5206217 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(5205003..5206217) Mycobacterium marinum M 6228507 YP_001852489.1 CDS MMAR_4226 NC_010612.1 5206427 5207590 D function unknown; probably involved in cellular metabolism; glycosyl transferase family protein 5206427..5207590 Mycobacterium marinum M 6228508 YP_001852490.1 CDS MMAR_4227 NC_010612.1 5207613 5207948 R hypothetical protein complement(5207613..5207948) Mycobacterium marinum M 6228509 YP_001852491.1 CDS tagA NC_010612.1 5207945 5208523 R involved in base excision repair. hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions; DNA-3-methyladenine glycosylase I TagA complement(5207945..5208523) Mycobacterium marinum M 6228510 YP_001852492.1 CDS MMAR_4229 NC_010612.1 5208520 5208891 R hypothetical protein complement(5208520..5208891) Mycobacterium marinum M 6228511 YP_001852493.1 CDS MMAR_4230 NC_010612.1 5208940 5209923 R putative glucosyl-3-phosphoglycerate synthase complement(5208940..5209923) Mycobacterium marinum M 6228512 YP_001852494.1 CDS folP2 NC_010612.1 5209920 5210795 R involved in dihydrofolate biosynthesis [catalytic activity : 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate]; dihydropteroate synthase 2 FolP2 complement(5209920..5210795) Mycobacterium marinum M 6228513 YP_001852495.1 CDS fadD6 NC_010612.1 5210885 5212666 R activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase complement(5210885..5212666) Mycobacterium marinum M 6228514 YP_001852496.1 CDS MMAR_4233 NC_010612.1 5212737 5213300 R hypothetical protein complement(5212737..5213300) Mycobacterium marinum M 6228515 YP_001852497.1 CDS MMAR_4234 NC_010612.1 5213388 5215532 D hypothetical protein 5213388..5215532 Mycobacterium marinum M 6228516 YP_001852498.1 CDS dapE NC_010612.1 5215560 5216624 R catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase complement(5215560..5216624) Mycobacterium marinum M 6228517 YP_001852499.1 CDS MMAR_4236 NC_010612.1 5216747 5217691 D function unknown, probably involved in cellular metabolism; transferase 5216747..5217691 Mycobacterium marinum M 6228518 YP_001852500.1 CDS MMAR_4237 NC_010612.1 5217746 5218246 R putative regulatory protein complement(5217746..5218246) Mycobacterium marinum M 6228519 YP_001852501.1 CDS MMAR_4238 NC_010612.1 5219131 5220414 R integral membrane transport protein complement(5219131..5220414) Mycobacterium marinum M 6228520 YP_001852502.1 CDS MMAR_4239 NC_010612.1 5221070 5221477 D hypothetical protein 5221070..5221477 Mycobacterium marinum M 6228521 YP_001852503.1 CDS MMAR_4240 NC_010612.1 5221634 5222815 R PPE family protein complement(5221634..5222815) Mycobacterium marinum M 6228522 YP_001852504.1 CDS MMAR_4241 NC_010612.1 5222855 5223154 R PPE family protein complement(5222855..5223154) Mycobacterium marinum M 6228523 YP_001852505.1 CDS MMAR_4242 NC_010612.1 5223901 5225166 D involved in transcriptional mechanism; transcriptional regulatory protein 5223901..5225166 Mycobacterium marinum M 6228524 YP_001852506.1 CDS fadD36 NC_010612.1 5225169 5226587 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(5225169..5226587) Mycobacterium marinum M 6228525 YP_001852507.1 CDS MMAR_4244 NC_010612.1 5226632 5227456 R hypothetical protein complement(5226632..5227456) Mycobacterium marinum M 6228526 YP_001852508.1 CDS MMAR_4245 NC_010612.1 5227460 5228368 R hypothetical protein complement(5227460..5228368) Mycobacterium marinum M 6228527 YP_001852509.1 CDS aldA_1 NC_010612.1 5228550 5230016 R oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD-dependent aldehyde dehydrogenase AldA complement(5228550..5230016) Mycobacterium marinum M 6228528 YP_001852510.1 CDS MMAR_4247 NC_010612.1 5230296 5230844 D hypothetical protein 5230296..5230844 Mycobacterium marinum M 6228529 YP_001852511.1 CDS MMAR_4248 NC_010612.1 5230844 5231272 D hypothetical protein 5230844..5231272 Mycobacterium marinum M 6228530 YP_001852512.1 CDS MMAR_4249 NC_010612.1 5231269 5231724 D hypothetical protein 5231269..5231724 Mycobacterium marinum M 6228531 YP_001852513.1 CDS ltp2 NC_010612.1 5231721 5232890 D lipid-transfer protein 5231721..5232890 Mycobacterium marinum M 6228532 YP_001852514.1 CDS MMAR_4251 NC_010612.1 5232898 5233527 D involved in transcriptional mechanism; transcriptional regulator 5232898..5233527 Mycobacterium marinum M 6228533 YP_001852515.1 CDS putA NC_010612.1 5233554 5234513 R oxidizes proline to glutamate for use as a carbon and nitrogen source [catalytic activity: L-proline + acceptor + H2O = (S)-1-pyrroline-5-carboxylate + reduced acceptor]; proline dehydrogenase, PutA complement(5233554..5234513) Mycobacterium marinum M 6228534 YP_001852516.1 CDS rocA NC_010612.1 5234513 5236144 R involved in the arginase pathway [catalytic activity: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O = L- glutamate + NADH]; pyrroline-5-carboxylate dehydrogenase, RocA complement(5234513..5236144) Mycobacterium marinum M 6228535 YP_001852517.1 CDS MMAR_4254 NC_010612.1 5236229 5237827 D may be a regulatory protein; hypothetical protein 5236229..5237827 Mycobacterium marinum M 6228536 YP_001852518.1 CDS MMAR_4255 NC_010612.1 5237915 5238718 D hypothetical protein 5237915..5238718 Mycobacterium marinum M 6228537 YP_001852519.1 CDS MMAR_4256 NC_010612.1 5238770 5238982 D hypothetical protein 5238770..5238982 Mycobacterium marinum M 6228538 YP_001852520.1 CDS MMAR_5553 NC_010612.1 5239082 5239369 D hypothetical protein 5239082..5239369 Mycobacterium marinum M 6228539 YP_001852521.1 CDS narK3_3 NC_010612.1 5239483 5240952 D involved in secretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; nitrite extrusion protein, NarK3_3 5239483..5240952 Mycobacterium marinum M 6228540 YP_001852522.1 CDS MMAR_4258 NC_010612.1 5241011 5241811 D could help control the pool of 3'-PHOSPHOADENOSIDE 5'-phosphosulfate, or its use in sulfite synthesis (by similarity); monophosphatase CysQ-like protein 5241011..5241811 Mycobacterium marinum M 6228541 YP_001852523.1 CDS MMAR_4259 NC_010612.1 5242294 5242998 D ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity [catalytic activity 1: ATP + sulfate = diphosphate + adenylylsulfate] and APS kinase catalyzes the synthesis of activated sulfate [catalytic activity 2: ATP + adenylylsulfate = ADP + 3'- phosphoadenylylsulfate]. first and second steps in the sulfate activation pathway. these reactions occurs early in the reductive branch of the cysteine biosynthetic pathway; bifunctional enzyme CysN/CysC-like: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase 5242294..5242998 Mycobacterium marinum M 6228542 YP_001852524.1 CDS MMAR_4260 NC_010612.1 5243079 5244002 D involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids; glycolipid sulfotransferase 5243079..5244002 Mycobacterium marinum M 6228543 YP_001852525.1 CDS MMAR_4261 NC_010612.1 5243989 5245071 D hypothetical protein 5243989..5245071 Mycobacterium marinum M 6228544 YP_001852526.1 CDS MMAR_4262 NC_010612.1 5245082 5246461 D function unknown - possible Na+/H+ antiporter; hypothetical protein 5245082..5246461 Mycobacterium marinum M 6228545 YP_001852527.1 CDS sat NC_010612.1 5246555 5247820 D ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms; sulfate adenylyltransferase 5246555..5247820 Mycobacterium marinum M 6228546 YP_001852528.1 CDS MMAR_4264 NC_010612.1 5247817 5248128 D hypothetical protein 5247817..5248128 Mycobacterium marinum M 6228547 YP_001852529.1 CDS narK3_4 NC_010612.1 5248292 5249704 R involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK3_4 complement(5248292..5249704) Mycobacterium marinum M 6228548 YP_001852530.1 CDS MMAR_4266 NC_010612.1 5250659 5252017 R PPE family protein complement(5250659..5252017) Mycobacterium marinum M 6228549 YP_001852531.1 CDS narK3_1 NC_010612.1 5252744 5253088 R involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK3 complement(5252744..5253088) Mycobacterium marinum M 6228550 YP_001852532.1 CDS MMAR_4268 NC_010612.1 5253610 5254803 D PPE family protein 5253610..5254803 Mycobacterium marinum M 6228551 YP_001852533.1 CDS MMAR_4269 NC_010612.1 5254885 5256084 D PPE family protein 5254885..5256084 Mycobacterium marinum M 6228552 YP_001852534.1 CDS MMAR_4270 NC_010612.1 5256511 5258523 D PE-PGRS family protein 5256511..5258523 Mycobacterium marinum M 6228553 YP_001852535.1 CDS MMAR_4271 NC_010612.1 5258558 5260069 R hypothetical protein complement(5258558..5260069) Mycobacterium marinum M 6228554 YP_001852536.1 CDS MMAR_4272 NC_010612.1 5260391 5263210 D hypothetical protein 5260391..5263210 Mycobacterium marinum M 6228555 YP_001852537.1 CDS MMAR_4273 NC_010612.1 5263274 5264371 R catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase complement(5263274..5264371) Mycobacterium marinum M 6228556 YP_001852538.1 CDS fdxC NC_010612.1 5264401 5264727 R ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxC complement(5264401..5264727) Mycobacterium marinum M 6228557 YP_001852539.1 CDS MMAR_4275 NC_010612.1 5264941 5265507 D hypothetical protein 5264941..5265507 Mycobacterium marinum M 6228558 YP_001852540.1 CDS fadH NC_010612.1 5265507 5267531 D catalyzes the NADP-dependent reduction of 2,4- dienoyl-CoA to yield trans-2- enoyl-CoA [catalytic activity: TRANS-2,3-didehydroacyl-CoA + NADP(+) = trans, TRANS-2,3,4,5-tetradehydroacyl-CoA + NADPH]; NADPH dependent 2,4-dienoyl-CoA reductase FadH 5265507..5267531 Mycobacterium marinum M 6228559 YP_001852541.1 CDS MMAR_4277 NC_010612.1 5267743 5268075 D TB8.4; function unknown function (secreted protein); putative antigen 5267743..5268075 Mycobacterium marinum M 6228560 YP_001852542.1 CDS MMAR_4278 NC_010612.1 5268285 5270984 R PE-PGRS family protein complement(5268285..5270984) Mycobacterium marinum M 6228561 YP_001852543.1 CDS fbiC NC_010612.1 5271556 5274126 R 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase complement(5271556..5274126) Mycobacterium marinum M 6228562 YP_001852544.1 CDS MMAR_4280 NC_010612.1 5274331 5275197 D PE family protein 5274331..5275197 Mycobacterium marinum M 6228563 YP_001852545.1 CDS MMAR_4281 NC_010612.1 5275227 5275586 R function unknown -possibly a transmembrane protein; hypothetical protein complement(5275227..5275586) Mycobacterium marinum M 6228564 YP_001852546.1 CDS mshB NC_010612.1 5275797 5276702 R involved in mycothiol biosynthesis. 1-D-myo- inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins)is converted to 1-D-myo-inosityl-2-amino-2- deoxy-alpha-D-glucopyranoside (GlcN-Ins) by this enzyme. seems to possesse weak mycothiol conjugate ami; N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB complement(5275797..5276702) Mycobacterium marinum M 6228565 YP_001852547.1 CDS MMAR_4284 NC_010612.1 5276876 5277499 D involved in transcriptional mechanism; transcriptional regulatory protein 5276876..5277499 Mycobacterium marinum M 6228566 YP_001852548.1 CDS MMAR_4287 NC_010612.1 5278846 5281047 R PE-PGRS family protein complement(5278846..5281047) Mycobacterium marinum M 6228568 YP_001852549.1 CDS lpqW NC_010612.1 5281258 5283165 R lipoprotein LpqW complement(5281258..5283165) Mycobacterium marinum M 6228569 YP_001852550.1 CDS typA NC_010612.1 5283263 5285149 R function unknown, probably interacts with the ribosomes in a GTP dependent manner; GTP-binding translation elongation factor TypA complement(5283263..5285149) Mycobacterium marinum M 6228570 YP_001852551.1 CDS mutT2 NC_010612.1 5285401 5285991 R involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool. 8-OXO-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to at to Gc transversions. mutt specifically degrades 8-OXO-dGTP to the monophosphate; mutator protein MutT2 complement(5285401..5285991) Mycobacterium marinum M 6228571 YP_001852552.1 CDS phhB NC_010612.1 5286050 5286361 D 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 5286050..5286361 Mycobacterium marinum M 6228572 YP_001852553.1 CDS pimE NC_010612.1 5286387 5287655 R involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase complement(5286387..5287655) Mycobacterium marinum M 6228573 YP_001852554.1 CDS MMAR_4293 NC_010612.1 5287797 5288423 D hypothetical protein 5287797..5288423 Mycobacterium marinum M 6228574 YP_001852555.1 CDS MMAR_4294 NC_010612.1 5288473 5289672 D hypothetical protein 5288473..5289672 Mycobacterium marinum M 6228575 YP_001852556.1 CDS MMAR_4295 NC_010612.1 5289704 5289850 R hypothetical protein complement(5289704..5289850) Mycobacterium marinum M 6228576 YP_001852557.1 CDS MMAR_4296 NC_010612.1 5289875 5290453 R hypothetical protein complement(5289875..5290453) Mycobacterium marinum M 6228577 YP_001852558.1 CDS MMAR_4297 NC_010612.1 5290527 5290715 R hypothetical protein complement(5290527..5290715) Mycobacterium marinum M 6228578 YP_001852559.1 CDS MMAR_4298 NC_010612.1 5290738 5291181 R hypothetical protein complement(5290738..5291181) Mycobacterium marinum M 6228579 YP_001852560.1 CDS MMAR_4299 NC_010612.1 5291238 5291753 D hypothetical protein 5291238..5291753 Mycobacterium marinum M 6228580 YP_001852561.1 CDS omt_2 NC_010612.1 5291768 5292604 D function unknown, but supposed involved in lipid metabolism; O-methyltransferase Omt_2 5291768..5292604 Mycobacterium marinum M 6228581 YP_001852562.1 CDS MMAR_4301 NC_010612.1 5292614 5292979 R involved in transcriptional mechanism; transcriptional regulatory protein complement(5292614..5292979) Mycobacterium marinum M 6228582 YP_001852563.1 CDS MMAR_4302 NC_010612.1 5293038 5293754 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 5293038..5293754 Mycobacterium marinum M 6228583 YP_001852564.1 CDS MMAR_4303 NC_010612.1 5293862 5294500 R hypothetical protein complement(5293862..5294500) Mycobacterium marinum M 6228584 YP_001852565.1 CDS MMAR_4304 NC_010612.1 5294497 5295195 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(5294497..5295195) Mycobacterium marinum M 6228585 YP_001852566.1 CDS mmpL13 NC_010612.1 5295197 5297539 R function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL13 complement(5295197..5297539) Mycobacterium marinum M 6228586 YP_001852567.1 CDS MMAR_4306 NC_010612.1 5297897 5298052 D hypothetical protein 5297897..5298052 Mycobacterium marinum M 6228587 YP_001852568.1 CDS MMAR_4307 NC_010612.1 5298189 5298950 R function unknown, supposed involved in cellular metabolism; short-chain type dehydrogenase/reductase complement(5298189..5298950) Mycobacterium marinum M 6228588 YP_001852569.1 CDS mcr NC_010612.1 5299008 5300105 R required for bile acid synthesis and for catabolism of branched-chain fatty acids; alpha-methylacyl-CoA racemase Mcr complement(5299008..5300105) Mycobacterium marinum M 6228589 YP_001852570.1 CDS echA10 NC_010612.1 5300259 5301062 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5300259..5301062 Mycobacterium marinum M 6228590 YP_001852571.1 CDS MMAR_4310 NC_010612.1 5301135 5302526 D oxidoreductase 5301135..5302526 Mycobacterium marinum M 6228591 YP_001852572.1 CDS MMAR_4311 NC_010612.1 5302532 5303251 R integral membrane protein complement(5302532..5303251) Mycobacterium marinum M 6228592 YP_001852573.1 CDS MMAR_4312 NC_010612.1 5303248 5304396 R hypothetical protein complement(5303248..5304396) Mycobacterium marinum M 6228593 YP_001852574.1 CDS MMAR_4313 NC_010612.1 5304583 5305632 D ortholog of pks10; possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]; chalcone synthase 5304583..5305632 Mycobacterium marinum M 6228594 YP_001852575.1 CDS MMAR_4314 NC_010612.1 5305626 5306135 D hypothetical protein 5305626..5306135 Mycobacterium marinum M 6228595 YP_001852576.1 CDS MMAR_4315 NC_010612.1 5306132 5307148 D function unknown; probably involved in cellular metabolism; oxidoreductase 5306132..5307148 Mycobacterium marinum M 6228596 YP_001852577.1 CDS MMAR_4316 NC_010612.1 5307272 5313196 R PE-PGRS family protein complement(5307272..5313196) Mycobacterium marinum M 6228597 YP_001852578.1 CDS echA1_1 NC_010612.1 5313624 5314427 R oxidize fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA1 complement(5313624..5314427) Mycobacterium marinum M 6228598 YP_001852579.1 CDS fadA6_3 NC_010612.1 5314424 5315572 R function unknown, but involved in lipid degradation [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]; acetyl-CoA acetyltransferase complement(5314424..5315572) Mycobacterium marinum M 6228599 YP_001852580.1 CDS MMAR_4319 NC_010612.1 5316112 5317977 D PPE family protein 5316112..5317977 Mycobacterium marinum M 6228600 YP_001852581.1 CDS MMAR_4320 NC_010612.1 5318444 5321764 D PPE family protein 5318444..5321764 Mycobacterium marinum M 6228601 YP_001852582.1 CDS MMAR_4321 NC_010612.1 5321829 5323595 R PE family protein complement(5321829..5323595) Mycobacterium marinum M 6228602 YP_001852583.1 CDS aldA_2 NC_010612.1 5324094 5325587 R oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD dependent aldehyde dehydrogenase complement(5324094..5325587) Mycobacterium marinum M 6228603 YP_001852584.1 CDS MMAR_4323 NC_010612.1 5326176 5327018 R single copy element; transposition of an IS110 family element; transposase complement(5326176..5327018) Mycobacterium marinum M 6228604 YP_001852585.1 CDS MMAR_5543 NC_010612.1 5327429 5327668 D hypothetical protein 5327429..5327668 Mycobacterium marinum M 6228605 YP_001852586.1 CDS MMAR_4324 NC_010612.1 5328392 5329561 R PPE family protein complement(5328392..5329561) Mycobacterium marinum M 6228606 YP_001852587.1 CDS MMAR_4325 NC_010612.1 5330081 5331355 D involved in transcriptional mechanism; TetR family transcriptional regulator 5330081..5331355 Mycobacterium marinum M 6228607 YP_001852588.1 CDS MMAR_4326 NC_010612.1 5331460 5332302 D function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 5331460..5332302 Mycobacterium marinum M 6228608 YP_001852589.1 CDS MMAR_4327 NC_010612.1 5332319 5332969 D function unknown, contains NADH-flavin reductase domain; hypothetical protein 5332319..5332969 Mycobacterium marinum M 6228609 YP_001852590.1 CDS metE NC_010612.1 5333386 5335677 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 5333386..5335677 Mycobacterium marinum M 6228610 YP_001852591.1 CDS MMAR_4329 NC_010612.1 5335755 5337488 R hypothetical protein complement(5335755..5337488) Mycobacterium marinum M 6228611 YP_001852592.1 CDS MMAR_4330 NC_010612.1 5337548 5338057 R hypothetical protein complement(5337548..5338057) Mycobacterium marinum M 6228612 YP_001852593.1 CDS ppdK NC_010612.1 5338125 5339795 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 5338125..5339795 Mycobacterium marinum M 6228613 YP_001852594.1 CDS MMAR_4332 NC_010612.1 5339792 5340397 D hypothetical protein 5339792..5340397 Mycobacterium marinum M 6228614 YP_001852595.1 CDS MMAR_4333 NC_010612.1 5340404 5341645 R hypothetical protein complement(5340404..5341645) Mycobacterium marinum M 6228615 YP_001852596.1 CDS ephC NC_010612.1 5341650 5342555 R thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphC complement(5341650..5342555) Mycobacterium marinum M 6228616 YP_001852597.1 CDS MMAR_4335 NC_010612.1 5343109 5343696 D involved in transcriptional mechanism; TetR family transcriptional regulator 5343109..5343696 Mycobacterium marinum M 6228617 YP_001852598.1 CDS MMAR_4336 NC_010612.1 5343699 5344175 R hypothetical protein complement(5343699..5344175) Mycobacterium marinum M 6228618 YP_001852599.1 CDS bpoB NC_010612.1 5344302 5345177 D supposed involved in detoxification reactions; peroxidase BpoB 5344302..5345177 Mycobacterium marinum M 6228619 YP_001852600.1 CDS gnd2 NC_010612.1 5345174 5346196 R similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase complement(5345174..5346196) Mycobacterium marinum M 6228620 YP_001852601.1 CDS zwf1 NC_010612.1 5346211 5347620 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(5346211..5347620) Mycobacterium marinum M 6228621 YP_001852602.1 CDS MMAR_4340 NC_010612.1 5347775 5348599 D hypothetical protein 5347775..5348599 Mycobacterium marinum M 6228622 YP_001852603.1 CDS MMAR_4341 NC_010612.1 5348632 5348811 D hypothetical protein 5348632..5348811 Mycobacterium marinum M 6228623 YP_001852604.1 CDS MMAR_4342 NC_010612.1 5348793 5349494 D hypothetical protein 5348793..5349494 Mycobacterium marinum M 6228624 YP_001852605.1 CDS MMAR_4343 NC_010612.1 5349591 5349920 R hypothetical protein complement(5349591..5349920) Mycobacterium marinum M 6228625 YP_001852606.1 CDS MMAR_4344 NC_010612.1 5349996 5350514 R hypothetical protein complement(5349996..5350514) Mycobacterium marinum M 6228626 YP_001852607.1 CDS MMAR_4345 NC_010612.1 5350829 5351389 R hypothetical protein complement(5350829..5351389) Mycobacterium marinum M 6228627 YP_001852608.1 CDS MMAR_4346 NC_010612.1 5351761 5352753 R PPE family protein complement(5351761..5352753) Mycobacterium marinum M 6228628 YP_001852609.1 CDS MMAR_4347 NC_010612.1 5353161 5354540 D hypothetical protein 5353161..5354540 Mycobacterium marinum M 6228629 YP_001852610.1 CDS MMAR_4348 NC_010612.1 5354543 5354881 D hypothetical protein 5354543..5354881 Mycobacterium marinum M 6228630 YP_001852611.1 CDS MMAR_4349 NC_010612.1 5354958 5355272 D hypothetical protein 5354958..5355272 Mycobacterium marinum M 6228631 YP_001852612.1 CDS MMAR_4350 NC_010612.1 5355391 5355990 D hypothetical protein 5355391..5355990 Mycobacterium marinum M 6228632 YP_001852613.1 CDS MMAR_4351 NC_010612.1 5355965 5357995 D hypothetical protein 5355965..5357995 Mycobacterium marinum M 6228633 YP_001852614.1 CDS MMAR_4352 NC_010612.1 5358011 5358793 R hypothetical protein complement(5358011..5358793) Mycobacterium marinum M 6228634 YP_001852615.1 CDS MMAR_4353 NC_010612.1 5359248 5360348 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(5359248..5360348) Mycobacterium marinum M 6228635 YP_001852616.1 CDS MMAR_4354 NC_010612.1 5360481 5361698 D hypothetical protein 5360481..5361698 Mycobacterium marinum M 6228636 YP_001852617.1 CDS ispH NC_010612.1 5361720 5362718 R catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase complement(5361720..5362718) Mycobacterium marinum M 6228637 YP_001852618.1 CDS MMAR_4356 NC_010612.1 5362828 5363445 D hypothetical protein 5362828..5363445 Mycobacterium marinum M 6228638 YP_001852619.1 CDS xseA NC_010612.1 5363442 5364689 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 5363442..5364689 Mycobacterium marinum M 6228639 YP_001852620.1 CDS xseB NC_010612.1 5364679 5364927 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 5364679..5364927 Mycobacterium marinum M 6228640 YP_001852621.1 CDS MMAR_4359 NC_010612.1 5364982 5366076 D function unknown, probably involved in cellular metabolism; cholesterol dehydrogenase 5364982..5366076 Mycobacterium marinum M 6228641 YP_001852622.1 CDS MMAR_4360 NC_010612.1 5366256 5366513 D hypothetical protein 5366256..5366513 Mycobacterium marinum M 6228642 YP_001852623.1 CDS MMAR_4361 NC_010612.1 5366608 5367009 R hypothetical protein complement(5366608..5367009) Mycobacterium marinum M 6228643 YP_001852624.1 CDS MMAR_4362 NC_010612.1 5367700 5369265 D PE-PGRS family protein 5367700..5369265 Mycobacterium marinum M 6228644 YP_001852625.1 CDS MMAR_4363 NC_010612.1 5369535 5371124 R function unknown; possible carboxylesterase type B (lipid metabolism) domain; carboxylesterase complement(5369535..5371124) Mycobacterium marinum M 6228645 YP_001852626.1 CDS MMAR_4364 NC_010612.1 5371313 5372470 D hypothetical protein 5371313..5372470 Mycobacterium marinum M 6228646 YP_001852627.1 CDS MMAR_4365 NC_010612.1 5372448 5373248 R hypothetical protein complement(5372448..5373248) Mycobacterium marinum M 6228647 YP_001852628.1 CDS MMAR_4366 NC_010612.1 5373276 5373923 R hypothetical protein complement(5373276..5373923) Mycobacterium marinum M 6228648 YP_001852629.1 CDS glpX NC_010612.1 5373992 5375080 D type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 5373992..5375080 Mycobacterium marinum M 6228649 YP_001852630.1 CDS fumC NC_010612.1 5375118 5376548 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 5375118..5376548 Mycobacterium marinum M 6228650 YP_001852631.1 CDS MMAR_4369 NC_010612.1 5376645 5377625 D membrane glycine and proline rich protein 5376645..5377625 Mycobacterium marinum M 6228651 YP_001852632.1 CDS MMAR_4370 NC_010612.1 5377655 5379163 R hypothetical protein complement(5377655..5379163) Mycobacterium marinum M 6228652 YP_001852633.1 CDS MMAR_4371 NC_010612.1 5379156 5380031 R probably involved in carbohydrate degradation. may hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non- carbohydrate moiety; glycosyl hydrolase complement(5379156..5380031) Mycobacterium marinum M 6228653 YP_001852634.1 CDS phoH2 NC_010612.1 5380103 5381404 R PhoH-like protein PhoH2 complement(5380103..5381404) Mycobacterium marinum M 6228654 YP_001852635.1 CDS MMAR_4373 NC_010612.1 5381401 5381700 R hypothetical protein complement(5381401..5381700) Mycobacterium marinum M 6228655 YP_001852636.1 CDS desA2 NC_010612.1 5381719 5382546 R thought to catalyze the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O]; acyl-[acyl-carrier protein] desaturase DesA2 complement(5381719..5382546) Mycobacterium marinum M 6228656 YP_001852637.1 CDS glyA NC_010612.1 5382603 5383883 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(5382603..5383883) Mycobacterium marinum M 6228657 YP_001852638.1 CDS coaA NC_010612.1 5384045 5384983 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 5384045..5384983 Mycobacterium marinum M 6228658 YP_001852639.1 CDS MMAR_4377 NC_010612.1 5385034 5386563 R PE-PGRS family protein complement(5385034..5386563) Mycobacterium marinum M 6228659 YP_001852640.1 CDS MMAR_4378 NC_010612.1 5386769 5387182 R hypothetical protein complement(5386769..5387182) Mycobacterium marinum M 6228660 YP_001852641.1 CDS MMAR_4379 NC_010612.1 5387372 5388742 R hypothetical protein complement(5387372..5388742) Mycobacterium marinum M 6228661 YP_001852642.1 CDS uppS NC_010612.1 5388981 5389769 R catalyzes the first committed step in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds one isoprene unit to omega,E- geranyl diphosphate. in mycobacterium; short (C15) chain Z-isoprenyl diphosphate synthase, UppS complement(5388981..5389769) Mycobacterium marinum M 6228662 YP_001852643.1 CDS MMAR_4381 NC_010612.1 5389916 5390656 D potential role involved in virulence; hemolysin-like protein 5389916..5390656 Mycobacterium marinum M 6228663 YP_001852644.1 CDS MMAR_4382 NC_010612.1 5390681 5391064 R hypothetical protein complement(5390681..5391064) Mycobacterium marinum M 6228664 YP_001852645.1 CDS MMAR_4383 NC_010612.1 5391078 5393102 R transmembrane protein complement(5391078..5393102) Mycobacterium marinum M 6228665 YP_001852646.1 CDS MMAR_4384 NC_010612.1 5393089 5393388 R hypothetical protein complement(5393089..5393388) Mycobacterium marinum M 6228666 YP_001852647.1 CDS mca NC_010612.1 5393385 5394257 R mycothiol-dependent detoxification enzyme, involved in mycothiol biosynthesis; mycothiol conjugate amidase Mca complement(5393385..5394257) Mycobacterium marinum M 6228667 YP_001852648.1 CDS MMAR_4386 NC_010612.1 5394399 5394833 D hypothetical protein 5394399..5394833 Mycobacterium marinum M 6228668 YP_001852649.1 CDS greA NC_010612.1 5395065 5395559 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 5395065..5395559 Mycobacterium marinum M 6228669 YP_001852650.1 CDS metB NC_010612.1 5395642 5396808 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(5395642..5396808) Mycobacterium marinum M 6228670 YP_001852651.1 CDS pra NC_010612.1 5396908 5397711 R proline-rich antigen, Pra complement(5396908..5397711) Mycobacterium marinum M 6228671 YP_001852652.1 CDS cbs NC_010612.1 5397907 5399301 R thought to be involved in homocysteine transulfuration [catalytic activity: L-serine + L- homocysteine = cystathionine + H2O]; cystathionine beta-synthase complement(5397907..5399301) Mycobacterium marinum M 6228672 YP_001852653.1 CDS lipU NC_010612.1 5399360 5400427 R hydrolyses lipids; lipase LipU complement(5399360..5400427) Mycobacterium marinum M 6228673 YP_001852654.1 CDS MMAR_4392 NC_010612.1 5400673 5401632 D hypothetical protein 5400673..5401632 Mycobacterium marinum M 6228674 YP_001852655.1 CDS fadA3 NC_010612.1 5401710 5402942 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 5401710..5402942 Mycobacterium marinum M 6228675 YP_001852656.1 CDS MMAR_4394 NC_010612.1 5403121 5403963 R hypothetical protein complement(5403121..5403963) Mycobacterium marinum M 6228676 YP_001852657.1 CDS echA9 NC_010612.1 5404211 5405248 D catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 5404211..5405248 Mycobacterium marinum M 6228677 YP_001852658.1 CDS echA8 NC_010612.1 5405260 5406033 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5405260..5406033 Mycobacterium marinum M 6228678 YP_001852659.1 CDS MMAR_4397 NC_010612.1 5406045 5407790 D hypothetical protein 5406045..5407790 Mycobacterium marinum M 6228679 YP_001852660.1 CDS MMAR_4398 NC_010612.1 5408042 5410774 D PE-PGRS family protein 5408042..5410774 Mycobacterium marinum M 6228680 YP_001852661.1 CDS MMAR_4399 NC_010612.1 5410995 5413727 D PE-PGRS family protein 5410995..5413727 Mycobacterium marinum M 6228681 YP_001852662.1 CDS MMAR_4400 NC_010612.1 5413760 5414143 R hypothetical protein complement(5413760..5414143) Mycobacterium marinum M 6228682 YP_001852663.1 CDS MMAR_4401 NC_010612.1 5414143 5414637 R hypothetical protein complement(5414143..5414637) Mycobacterium marinum M 6228683 YP_001852664.1 CDS lpqV NC_010612.1 5414843 5415310 D lipoprotein LpqV 5414843..5415310 Mycobacterium marinum M 6228684 YP_001852665.1 CDS MMAR_4403 NC_010612.1 5415413 5416477 D hypothetical protein 5415413..5416477 Mycobacterium marinum M 6228685 YP_001852666.1 CDS MMAR_4404 NC_010612.1 5416478 5417347 R hypothetical protein complement(5416478..5417347) Mycobacterium marinum M 6228686 YP_001852667.1 CDS MMAR_4405 NC_010612.1 5417371 5418243 R hypothetical protein complement(5417371..5418243) Mycobacterium marinum M 6228687 YP_001852668.1 CDS MMAR_4406 NC_010612.1 5418276 5418749 R hypothetical protein complement(5418276..5418749) Mycobacterium marinum M 6228688 YP_001852669.1 CDS MMAR_4407 NC_010612.1 5418899 5421412 R PE-PGRS family protein complement(5418899..5421412) Mycobacterium marinum M 6228689 YP_001852670.1 CDS MMAR_4408 NC_010612.1 5421973 5422854 R hypothetical protein complement(5421973..5422854) Mycobacterium marinum M 6228690 YP_001852671.1 CDS MMAR_4409 NC_010612.1 5422847 5423743 R acid phosphatase complement(5422847..5423743) Mycobacterium marinum M 6228691 YP_001852672.1 CDS aslA NC_010612.1 5423744 5425294 R thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase, AslA complement(5423744..5425294) Mycobacterium marinum M 6228692 YP_001852673.1 CDS MMAR_4411 NC_010612.1 5425406 5426464 R hypothetical protein complement(5425406..5426464) Mycobacterium marinum M 6228693 YP_001852674.1 CDS fadD14 NC_010612.1 5426572 5428203 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(5426572..5428203) Mycobacterium marinum M 6228694 YP_001852675.1 CDS MMAR_4413 NC_010612.1 5428325 5429524 R hypothetical protein complement(5428325..5429524) Mycobacterium marinum M 6228695 YP_001852676.1 CDS MMAR_4414 NC_010612.1 5429919 5430704 R hypothetical protein complement(5429919..5430704) Mycobacterium marinum M 6228696 YP_001852677.1 CDS MMAR_4415 NC_010612.1 5430837 5431349 D function unknown; contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential; hypothetical protein 5430837..5431349 Mycobacterium marinum M 6228697 YP_001852678.1 CDS MMAR_4416 NC_010612.1 5431369 5432955 R hypothetical protein complement(5431369..5432955) Mycobacterium marinum M 6228698 YP_001852679.1 CDS MMAR_4417 NC_010612.1 5433015 5433791 R hypothetical protein complement(5433015..5433791) Mycobacterium marinum M 6228699 YP_001852680.1 CDS MMAR_4418 NC_010612.1 5433875 5434498 R involved in transcriptional mechanism; transcriptional regulatory protein complement(5433875..5434498) Mycobacterium marinum M 6228700 YP_001852681.1 CDS MMAR_4419 NC_010612.1 5434560 5435363 D hypothetical protein 5434560..5435363 Mycobacterium marinum M 6228701 YP_001852682.1 CDS gcvT_2 NC_010612.1 5435560 5438004 D the glycine cleavage system catalyzes the degradation of glycine [catalytic activity: (6S)- tetrahydrofolate + s-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein]; aminomethyltransferase GcvT_2 5435560..5438004 Mycobacterium marinum M 6228702 YP_001852683.1 CDS solA NC_010612.1 5438011 5439153 D catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 5438011..5439153 Mycobacterium marinum M 6228703 YP_001852684.1 CDS MMAR_4422 NC_010612.1 5439150 5440298 D function unknown; involved in cellular metabolism; dioxygenase 5439150..5440298 Mycobacterium marinum M 6228704 YP_001852685.1 CDS MMAR_4423 NC_010612.1 5440310 5441140 D involved in transcriptional mechanism; transcriptional regulatory protein 5440310..5441140 Mycobacterium marinum M 6228705 YP_001852686.1 CDS MMAR_4424 NC_010612.1 5441306 5442022 D hypothetical protein 5441306..5442022 Mycobacterium marinum M 6228706 YP_001852687.1 CDS MMAR_4425 NC_010612.1 5442125 5442868 R function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis; methylase complement(5442125..5442868) Mycobacterium marinum M 6228707 YP_001852688.1 CDS MMAR_4426 NC_010612.1 5442929 5443999 R involved in transcriptional mechanism; transcriptional regulatory protein complement(5442929..5443999) Mycobacterium marinum M 6228708 YP_001852689.1 CDS MMAR_4427 NC_010612.1 5444274 5445830 D function unknown; probably involved in cellular metabolism, probably electron-transfer-linked; dehydrogenase fad flavoprotein GMC oxidoreductase 5444274..5445830 Mycobacterium marinum M 6228709 YP_001852690.1 CDS MMAR_4428 NC_010612.1 5445832 5446710 R may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide]; haloalkane dehalogenase complement(5445832..5446710) Mycobacterium marinum M 6228710 YP_001852691.1 CDS MMAR_4429 NC_010612.1 5447124 5449940 R thought to be involved in fatty acid transport; transmembrane transport protein MmpL complement(5447124..5449940) Mycobacterium marinum M 6228711 YP_001852692.1 CDS cyp138B1 NC_010612.1 5450494 5451864 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 138B1 Cyp138B1 complement(5450494..5451864) Mycobacterium marinum M 6228712 YP_001852693.1 CDS MMAR_4431 NC_010612.1 5451898 5452848 R hypothetical protein complement(5451898..5452848) Mycobacterium marinum M 6228713 YP_001852694.1 CDS MMAR_4432 NC_010612.1 5452871 5453572 R hypothetical protein complement(5452871..5453572) Mycobacterium marinum M 6228714 YP_001852695.1 CDS MMAR_4433 NC_010612.1 5453621 5454790 R function unknown; domain identity suggests BtaA, s- adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase - with a potential role in methylation during lipid biosynthesis; methylase complement(5453621..5454790) Mycobacterium marinum M 6228715 YP_001852696.1 CDS MMAR_4434 NC_010612.1 5455068 5455553 D hypothetical protein 5455068..5455553 Mycobacterium marinum M 6228716 YP_001852697.1 CDS MMAR_4435 NC_010612.1 5456235 5456615 R hypothetical protein complement(5456235..5456615) Mycobacterium marinum M 6228717 YP_001852698.1 CDS MMAR_4436 NC_010612.1 5456700 5457338 D hypothetical protein 5456700..5457338 Mycobacterium marinum M 6228718 YP_001852699.1 CDS MMAR_4437 NC_010612.1 5457504 5458208 D hypothetical protein 5457504..5458208 Mycobacterium marinum M 6228719 YP_001852700.1 CDS MMAR_4438 NC_010612.1 5458337 5459869 R hypothetical protein complement(5458337..5459869) Mycobacterium marinum M 6228720 YP_001852701.1 CDS MMAR_4439 NC_010612.1 5460261 5460929 R hypothetical protein complement(5460261..5460929) Mycobacterium marinum M 6228721 YP_001852702.1 CDS MMAR_4440 NC_010612.1 5460926 5461981 R hypothetical protein complement(5460926..5461981) Mycobacterium marinum M 6228722 YP_001852703.1 CDS MMAR_4441 NC_010612.1 5462196 5462510 D hypothetical protein 5462196..5462510 Mycobacterium marinum M 6228723 YP_001852704.1 CDS MMAR_4442 NC_010612.1 5462521 5463915 R integration of phage genome into host DNA; prophage integrase complement(5462521..5463915) Mycobacterium marinum M 6228724 YP_001852705.1 CDS MMAR_4443 NC_010612.1 5464024 5464686 R phage DNA recombination function; site-specific recombinase complement(5464024..5464686) Mycobacterium marinum M 6228725 YP_001852706.1 CDS MMAR_4444 NC_010612.1 5464697 5465899 R hypothetical protein complement(5464697..5465899) Mycobacterium marinum M 6228726 YP_001852707.1 CDS MMAR_4445 NC_010612.1 5465896 5466138 R hypothetical protein complement(5465896..5466138) Mycobacterium marinum M 6228727 YP_001852708.1 CDS MMAR_4446 NC_010612.1 5466465 5466848 R hypothetical protein complement(5466465..5466848) Mycobacterium marinum M 6228728 YP_001852709.1 CDS MMAR_4447 NC_010612.1 5467159 5467785 R hypothetical protein complement(5467159..5467785) Mycobacterium marinum M 6228729 YP_001852710.1 CDS MMAR_4448 NC_010612.1 5468224 5469375 D hypothetical protein 5468224..5469375 Mycobacterium marinum M 6228730 YP_001852711.1 CDS MMAR_4449 NC_010612.1 5469388 5469633 D hypothetical protein 5469388..5469633 Mycobacterium marinum M 6228731 YP_001852712.1 CDS MMAR_4450 NC_010612.1 5469703 5470605 R hypothetical protein complement(5469703..5470605) Mycobacterium marinum M 6228732 YP_001852713.1 CDS MMAR_4451 NC_010612.1 5471205 5472029 D PE family protein 5471205..5472029 Mycobacterium marinum M 6228734 YP_001852714.1 CDS MMAR_4452 NC_010612.1 5472099 5473271 D PPE family protein 5472099..5473271 Mycobacterium marinum M 6228735 YP_001852715.1 CDS esxP NC_010612.1 5473419 5473715 D EsaT-6 like protein EsxP 5473419..5473715 Mycobacterium marinum M 6228736 YP_001852716.1 CDS esxN_1 NC_010612.1 5473754 5474038 D EsaT-6 like protein EsxN 5473754..5474038 Mycobacterium marinum M 6228737 YP_001852717.1 CDS trcR NC_010612.1 5474308 5475072 D sensor part of the two-component regulatory system TrcS/TrcR. involved in transcriptional autoactivation: TrcR activates its own expression by interacting with the AT-rich sequence of the TrcR promoter; two-component transcriptional regulator TrcR 5474308..5475072 Mycobacterium marinum M 6228738 YP_001852718.1 CDS trcS NC_010612.1 5475080 5476624 D sensor part of the two-component regulatory system TrcS/TrcR; two-component sensor histidine kinase TrcS 5475080..5476624 Mycobacterium marinum M 6228739 YP_001852719.1 CDS MMAR_4457 NC_010612.1 5476662 5477402 D function unknown, possibly involved in amino acid transport and metabolism; hydantoin racemase 5476662..5477402 Mycobacterium marinum M 6228740 YP_001852720.1 CDS MMAR_4458 NC_010612.1 5477489 5477782 R hypothetical protein complement(5477489..5477782) Mycobacterium marinum M 6228741 YP_001852721.1 CDS MMAR_4459 NC_010612.1 5477886 5478833 R function unknown; identity to GppA, exopolyphosphatase [nucleotide transport and metabolism / inorganic ion transport and metabolism]; hypothetical protein complement(5477886..5478833) Mycobacterium marinum M 6228742 YP_001852722.1 CDS MMAR_4460 NC_010612.1 5478853 5479344 R hypothetical protein complement(5478853..5479344) Mycobacterium marinum M 6228743 YP_001852723.1 CDS MMAR_4461 NC_010612.1 5479337 5480038 R hypothetical protein complement(5479337..5480038) Mycobacterium marinum M 6228744 YP_001852724.1 CDS eno NC_010612.1 5480072 5481358 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(5480072..5481358) Mycobacterium marinum M 6228745 YP_001852725.1 CDS lpqU NC_010612.1 5481439 5482170 R lipoprotein LpqU complement(5481439..5482170) Mycobacterium marinum M 6228746 YP_001852726.1 CDS MMAR_4464 NC_010612.1 5482525 5483625 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase complement(5482525..5483625) Mycobacterium marinum M 6228747 YP_001852727.1 CDS mfd NC_010612.1 5483622 5487290 R involved in nucleotide excision repair. necessary for strand-specific repair. a lesion in the template strand blocks the RNA polymerase complex (RNAP). the RNAP- DNA-RNA complex is specifically recognized by TrcF which releases RNAP and the truncated transcript; the TcrF may replace RNAP at the lesion site and then recruit the UvrA/B/C repair system; transcription-repair coupling factor Mfd (TrcF) complement(5483622..5487290) Mycobacterium marinum M 6228748 YP_001852728.1 CDS MMAR_4466 NC_010612.1 5487357 5487986 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(5487357..5487986) Mycobacterium marinum M 6228749 YP_001852729.1 CDS glmU NC_010612.1 5488427 5489905 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 5488427..5489905 Mycobacterium marinum M 6228751 YP_001852730.1 CDS prsA NC_010612.1 5490018 5490998 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 5490018..5490998 Mycobacterium marinum M 6228752 YP_001852731.1 CDS MMAR_4469 NC_010612.1 5490999 5491367 D arsenate reductase 5490999..5491367 Mycobacterium marinum M 6228753 YP_001852732.1 CDS lpqT NC_010612.1 5491364 5492020 D lipoprotein LpqT 5491364..5492020 Mycobacterium marinum M 6228754 YP_001852733.1 CDS rplY NC_010612.1 5493105 5493749 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 5493105..5493749 Mycobacterium marinum M 6228756 YP_001852734.1 CDS pth NC_010612.1 5493762 5494337 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 5493762..5494337 Mycobacterium marinum M 6228757 YP_001852735.1 CDS MMAR_4474 NC_010612.1 5494351 5495259 R hypothetical protein complement(5494351..5495259) Mycobacterium marinum M 6228758 YP_001852736.1 CDS MMAR_4475 NC_010612.1 5495603 5497123 D PE-PGRS family protein 5495603..5497123 Mycobacterium marinum M 6228759 YP_001852737.1 CDS pks16 NC_010612.1 5497211 5498845 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(5497211..5498845) Mycobacterium marinum M 6228760 YP_001852738.1 CDS ispE NC_010612.1 5499211 5500134 R catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(5499211..5500134) Mycobacterium marinum M 6228761 YP_001852739.1 CDS ksgA NC_010612.1 5500232 5501056 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(5500232..5501056) Mycobacterium marinum M 6228762 YP_001852740.1 CDS rpfB NC_010612.1 5501161 5502249 R thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulates the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis; resuscitation-promoting factor RpfB complement(5501161..5502249) Mycobacterium marinum M 6228763 YP_001852741.1 CDS tatD NC_010612.1 5502459 5503307 R DNAse involved in proteins export. this sec- independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity); deoxyribonuclease TatD complement(5502459..5503307) Mycobacterium marinum M 6228764 YP_001852742.1 CDS metS NC_010612.1 5503341 5504897 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 5503341..5504897 Mycobacterium marinum M 6228765 YP_001852743.1 CDS MMAR_4482 NC_010612.1 5505172 5505858 D function unknown but may be involved in RNA methylation; methyltransferase 5505172..5505858 Mycobacterium marinum M 6228766 YP_001852744.1 CDS cyp135B3 NC_010612.1 5505905 5507278 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 135B3 Cyp135B3 complement(5505905..5507278) Mycobacterium marinum M 6228767 YP_001852745.1 CDS cysE_1 NC_010612.1 5508477 5509043 D involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine]; serine acetyltransferase CysE 5508477..5509043 Mycobacterium marinum M 6228768 YP_001852746.1 CDS MMAR_4485 NC_010612.1 5509111 5510814 R hypothetical protein complement(5509111..5510814) Mycobacterium marinum M 6228769 YP_001852747.1 CDS MMAR_4486 NC_010612.1 5511312 5512496 D function unknown, probably involved in cellular metabolism; dehydrogenase 5511312..5512496 Mycobacterium marinum M 6228770 YP_001852748.1 CDS MMAR_4487 NC_010612.1 5512493 5513398 D the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; alternative RNA polymerase sigma factor 5512493..5513398 Mycobacterium marinum M 6228771 YP_001852749.1 CDS pabD NC_010612.1 5513460 5514773 D catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I 5513460..5514773 Mycobacterium marinum M 6228772 YP_001852750.1 CDS MMAR_4489 NC_010612.1 5514880 5516226 D hypothetical protein 5514880..5516226 Mycobacterium marinum M 6228773 YP_001852751.1 CDS MMAR_4490 NC_010612.1 5516234 5517088 R hypothetical protein complement(5516234..5517088) Mycobacterium marinum M 6228774 YP_001852752.1 CDS MMAR_4491 NC_010612.1 5517114 5518670 D hypothetical protein 5517114..5518670 Mycobacterium marinum M 6228775 YP_001852753.1 CDS arcA NC_010612.1 5518667 5519875 R catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase complement(5518667..5519875) Mycobacterium marinum M 6228776 YP_001852754.1 CDS MMAR_4493 NC_010612.1 5519934 5520551 D hypothetical protein 5519934..5520551 Mycobacterium marinum M 6228777 YP_001852755.1 CDS MMAR_4494 NC_010612.1 5520577 5521230 R hypothetical protein complement(5520577..5521230) Mycobacterium marinum M 6228778 YP_001852756.1 CDS MMAR_4495 NC_010612.1 5521258 5521935 R hypothetical protein complement(5521258..5521935) Mycobacterium marinum M 6228779 YP_001852757.1 CDS MMAR_4496 NC_010612.1 5522008 5522958 R hypothetical protein complement(5522008..5522958) Mycobacterium marinum M 6228780 YP_001852758.1 CDS MMAR_4497 NC_010612.1 5523173 5523919 D thought to cause methylation; methyltransferase 5523173..5523919 Mycobacterium marinum M 6228781 YP_001852759.1 CDS MMAR_4498 NC_010612.1 5523955 5524206 R hypothetical protein complement(5523955..5524206) Mycobacterium marinum M 6228782 YP_001852760.1 CDS MMAR_4499 NC_010612.1 5524321 5525115 R hypothetical protein complement(5524321..5525115) Mycobacterium marinum M 6228783 YP_001852761.1 CDS MMAR_4500 NC_010612.1 5525226 5525762 D hypothetical protein 5525226..5525762 Mycobacterium marinum M 6228784 YP_001852762.1 CDS MMAR_4501 NC_010612.1 5526073 5527245 D PPE family protein 5526073..5527245 Mycobacterium marinum M 6228785 YP_001852763.1 CDS MMAR_4502 NC_010612.1 5527434 5528300 D function unknown, possibly involved in cell envelope biogenesis, outer membrane; teichoic acid biosynthesis protein 5527434..5528300 Mycobacterium marinum M 6228786 YP_001852764.1 CDS MMAR_4503 NC_010612.1 5528317 5529822 D function unknown, possibly involved in lipopolysaccharide synthesis; hypothetical protein 5528317..5529822 Mycobacterium marinum M 6228787 YP_001852765.1 CDS MMAR_4504 NC_010612.1 5529837 5531312 D function unknown, possible membrane protein involved in the export of O-antigen and teichoic acid; hypothetical protein 5529837..5531312 Mycobacterium marinum M 6228788 YP_001852766.1 CDS MMAR_4505 NC_010612.1 5531309 5533300 D probably involved in cell wall synthesis; glycosyltransferase 5531309..5533300 Mycobacterium marinum M 6228789 YP_001852767.1 CDS MMAR_4506 NC_010612.1 5533297 5534352 D function unknown, contains RfaG, glycosyltransferase domain. may be involved in cell envelope biogenesis, outer membrane; hypothetical protein 5533297..5534352 Mycobacterium marinum M 6228790 YP_001852768.1 CDS MMAR_4507 NC_010612.1 5534367 5535326 R hypothetical protein complement(5534367..5535326) Mycobacterium marinum M 6228791 YP_001852769.1 CDS MMAR_4508 NC_010612.1 5535361 5537322 R hypothetical protein complement(5535361..5537322) Mycobacterium marinum M 6228792 YP_001852770.1 CDS MMAR_4509 NC_010612.1 5537759 5538718 D hypothetical protein 5537759..5538718 Mycobacterium marinum M 6228793 YP_001852771.1 CDS MMAR_4510 NC_010612.1 5538698 5539495 R hypothetical protein complement(5538698..5539495) Mycobacterium marinum M 6228794 YP_001852772.1 CDS MMAR_4511 NC_010612.1 5539596 5540261 R hypothetical protein complement(5539596..5540261) Mycobacterium marinum M 6228795 YP_001852773.1 CDS MMAR_4512 NC_010612.1 5540420 5541178 D function unknown; hydrolytic enzyme probably involved in cellular metabolism; amidohydrolase 5540420..5541178 Mycobacterium marinum M 6228796 YP_001852774.1 CDS MMAR_4513 NC_010612.1 5541157 5541918 R hypothetical protein complement(5541157..5541918) Mycobacterium marinum M 6228797 YP_001852775.1 CDS MMAR_4514 NC_010612.1 5542012 5543133 R function unknown; probably involved in cellular metabolism; glycosyl transferase family protein complement(5542012..5543133) Mycobacterium marinum M 6228798 YP_001852776.1 CDS MMAR_4515 NC_010612.1 5543130 5544605 R hypothetical protein complement(5543130..5544605) Mycobacterium marinum M 6228799 YP_001852777.1 CDS MMAR_4516 NC_010612.1 5544602 5545987 R function unknown, possibly involved in cell envelope biogenesis, outer membrane; hypothetical protein complement(5544602..5545987) Mycobacterium marinum M 6228800 YP_001852778.1 CDS MMAR_4517 NC_010612.1 5546323 5547105 D hypothetical protein 5546323..5547105 Mycobacterium marinum M 6228801 YP_001852779.1 CDS MMAR_4518 NC_010612.1 5547340 5548518 R hypothetical protein complement(5547340..5548518) Mycobacterium marinum M 6228803 YP_001852780.1 CDS rimJ NC_010612.1 5548725 5549378 R this enzyme acetylates the N-terminal alanine of ribosomal protein S5 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine]; ribosomal-protein-alanine acetyltransferase RimJ complement(5548725..5549378) Mycobacterium marinum M 6228804 YP_001852781.1 CDS moeA1 NC_010612.1 5549401 5550690 R involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes; molybdopterin biosynthesis protein MoeA1 complement(5549401..5550690) Mycobacterium marinum M 6228805 YP_001852782.1 CDS galU NC_010612.1 5550742 5551659 R may play a role in stationary phase survival [catalytic activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose]; UTP--glucose-1-phosphate uridylyltransferase GalU complement(5550742..5551659) Mycobacterium marinum M 6228806 YP_001852783.1 CDS MMAR_4522 NC_010612.1 5551737 5552330 D hypothetical protein 5551737..5552330 Mycobacterium marinum M 6228807 YP_001852784.1 CDS MMAR_4523 NC_010612.1 5552405 5552740 D putative serine rich protein 5552405..5552740 Mycobacterium marinum M 6228808 YP_001852785.1 CDS MMAR_4524 NC_010612.1 5552807 5553466 D hypothetical protein 5552807..5553466 Mycobacterium marinum M 6228809 YP_001852786.1 CDS mscL NC_010612.1 5553543 5553998 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 5553543..5553998 Mycobacterium marinum M 6228810 YP_001852787.1 CDS moaB2 NC_010612.1 5554018 5554563 R thought to be involved in molybdopterin biosynthesis. catalyzes the dehydratation of 4A- hydroxytetrahydropterins [catalytic activity: (6R)-6-(L- erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro -4 A- hydroxypterin = (6R)-6-(L-erythro-1,2- dihydroxypropyl)- 7,8-dihydro-6H-pterin + H(2)O.]; pterin-4-alpha-carbinolamine dehydratase MoaB2 complement(5554018..5554563) Mycobacterium marinum M 6228811 YP_001852788.1 CDS pepD NC_010612.1 5554560 5555999 R function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues); serine protease PepD complement(5554560..5555999) Mycobacterium marinum M 6228812 YP_001852789.1 CDS mprB NC_010612.1 5556099 5557634 R sensor part of a two-component regulatory system (supposed MprAB system); two-component sensor kinase MprB complement(5556099..5557634) Mycobacterium marinum M 6228813 YP_001852790.1 CDS mprA NC_010612.1 5557634 5558332 R regulator part of a two-component regulatory system (supposed MprAB system); two component response transcriptional regulatory protein MprA complement(5557634..5558332) Mycobacterium marinum M 6228814 YP_001852791.1 CDS rpmF NC_010612.1 5558599 5558772 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(5558599..5558772) Mycobacterium marinum M 6228815 YP_001852792.1 CDS MMAR_4531 NC_010612.1 5559038 5560750 D hypothetical protein 5559038..5560750 Mycobacterium marinum M 6228816 YP_001852793.1 CDS fadE13 NC_010612.1 5560747 5561895 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE13 5560747..5561895 Mycobacterium marinum M 6228817 YP_001852794.1 CDS accD2 NC_010612.1 5561945 5563540 D involved in fatty acid metabolism; acetyl-/propionyl-CoA carboxylase subunit beta 5561945..5563540 Mycobacterium marinum M 6228818 YP_001852795.1 CDS accA2 NC_010612.1 5563540 5565528 D this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein]; acetyl-/propionyl-coenzyme A carboxylase alpha chain, AccA2 5563540..5565528 Mycobacterium marinum M 6228819 YP_001852796.1 CDS fadE12 NC_010612.1 5565528 5566694 D function unknown, but involved in lipid metabolism; acyl-CoA dehydrogenase FadE12 5565528..5566694 Mycobacterium marinum M 6228820 YP_001852797.1 CDS echA7 NC_010612.1 5566705 5567478 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5566705..5567478 Mycobacterium marinum M 6228821 YP_001852798.1 CDS MMAR_4537 NC_010612.1 5567529 5567792 D PE-PGRS family protein 5567529..5567792 Mycobacterium marinum M 6228822 YP_001852799.1 CDS MMAR_4538 NC_010612.1 5567853 5568041 D hypothetical protein 5567853..5568041 Mycobacterium marinum M 6228823 YP_001852800.1 CDS MMAR_4539 NC_010612.1 5568148 5568750 D hypothetical protein 5568148..5568750 Mycobacterium marinum M 6228824 YP_001852801.1 CDS MMAR_4540 NC_010612.1 5568778 5570775 R hypothetical protein complement(5568778..5570775) Mycobacterium marinum M 6228825 YP_001852802.1 CDS MMAR_4541 NC_010612.1 5570768 5572159 R chelation, introducing a magnesium ion into specific substrate; magnesium chelatase complement(5570768..5572159) Mycobacterium marinum M 6228826 YP_001852803.1 CDS purH NC_010612.1 5572239 5573810 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(5572239..5573810) Mycobacterium marinum M 6228827 YP_001852804.1 CDS purN NC_010612.1 5573807 5574454 R glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase complement(5573807..5574454) Mycobacterium marinum M 6228828 YP_001852805.1 CDS MMAR_4544 NC_010612.1 5574507 5575925 R integral membrane protein complement(5574507..5575925) Mycobacterium marinum M 6228829 YP_001852806.1 CDS MMAR_4545 NC_010612.1 5575965 5576879 R transmembrane protein complement(5575965..5576879) Mycobacterium marinum M 6228830 YP_001852807.1 CDS MMAR_4546 NC_010612.1 5577116 5577949 D oxidoreductase 5577116..5577949 Mycobacterium marinum M 6228831 YP_001852808.1 CDS MMAR_4547 NC_010612.1 5577957 5579477 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(5577957..5579477) Mycobacterium marinum M 6228832 YP_001852809.1 CDS MMAR_4548 NC_010612.1 5579641 5580972 D PE-PGRS family protein 5579641..5580972 Mycobacterium marinum M 6228833 YP_001852810.1 CDS sucD NC_010612.1 5581063 5581965 R Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha complement(5581063..5581965) Mycobacterium marinum M 6228834 YP_001852811.1 CDS sucC NC_010612.1 5581980 5583143 R catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta complement(5581980..5583143) Mycobacterium marinum M 6228835 YP_001852812.1 CDS MMAR_4551 NC_010612.1 5583419 5584486 D hypothetical protein 5583419..5584486 Mycobacterium marinum M 6228836 YP_001852813.1 CDS MMAR_4552 NC_010612.1 5584601 5585074 D hypothetical protein 5584601..5585074 Mycobacterium marinum M 6228837 YP_001852814.1 CDS uvrD1 NC_010612.1 5585153 5587462 R involved in nucleotide excision repair. has a 3'-5' helicase activity in presence of ATP. preferred substrate being one with both single and double stranded regions of DNA; ATP-dependent DNA helicase II UvrD1 complement(5585153..5587462) Mycobacterium marinum M 6228838 YP_001852815.1 CDS MMAR_4554 NC_010612.1 5587543 5589549 R PPE family protein complement(5587543..5589549) Mycobacterium marinum M 6228839 YP_001852816.1 CDS MMAR_4555 NC_010612.1 5589940 5590254 D hypothetical protein 5589940..5590254 Mycobacterium marinum M 6228840 YP_001852817.1 CDS fbpC_2 NC_010612.1 5590317 5591288 D proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted antigen 85-C FbpC_2 5590317..5591288 Mycobacterium marinum M 6228841 YP_001852818.1 CDS pgi NC_010612.1 5591331 5592995 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 5591331..5592995 Mycobacterium marinum M 6228842 YP_001852819.1 CDS MMAR_4558 NC_010612.1 5593095 5593844 R function unknown, possibly involved in cellular metabolism; short chain dehydrogenase complement(5593095..5593844) Mycobacterium marinum M 6228843 YP_001852820.1 CDS MMAR_4559 NC_010612.1 5593933 5594796 R this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents [catalytic activity: hydrolysis of DNA containing ring-opened N7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimide]; formamidopyrimidine-DNA glycosylase complement(5593933..5594796) Mycobacterium marinum M 6228844 YP_001852821.1 CDS MMAR_4560 NC_010612.1 5594844 5595905 R PE-PGRS family protein complement(5594844..5595905) Mycobacterium marinum M 6228845 YP_001852822.1 CDS MMAR_4561 NC_010612.1 5596024 5597733 R PE-PGRS family protein complement(5596024..5597733) Mycobacterium marinum M 6228846 YP_001852823.1 CDS MMAR_4562 NC_010612.1 5597809 5599524 R PE-PGRS family protein complement(5597809..5599524) Mycobacterium marinum M 6228847 YP_001852824.1 CDS MMAR_4563 NC_010612.1 5599695 5600438 R catalyzes the formation of precorrin 6x from precorrin 5; precorrin 6A synthase complement(5599695..5600438) Mycobacterium marinum M 6228848 YP_001852825.1 CDS MMAR_4564 NC_010612.1 5600594 5601499 D hypothetical protein 5600594..5601499 Mycobacterium marinum M 6228849 YP_001852826.1 CDS MMAR_4565 NC_010612.1 5601496 5602800 D function unknown, probably involved in cellular metabolism; monooxygenase 5601496..5602800 Mycobacterium marinum M 6228850 YP_001852827.1 CDS MMAR_4567 NC_010612.1 5603357 5604121 D hypothetical protein 5603357..5604121 Mycobacterium marinum M 6228851 YP_001852828.1 CDS MMAR_4568 NC_010612.1 5604266 5605135 D function unknown; probably involved in cellular metabolism; oxidoreductase 5604266..5605135 Mycobacterium marinum M 6228852 YP_001852829.1 CDS echA12_2 NC_010612.1 5605139 5605945 R oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA12_2 complement(5605139..5605945) Mycobacterium marinum M 6228853 YP_001852830.1 CDS MMAR_4570 NC_010612.1 5606026 5606949 D hypothetical protein 5606026..5606949 Mycobacterium marinum M 6228854 YP_001852831.1 CDS MMAR_4571 NC_010612.1 5607069 5608880 D PE-PGRS family protein 5607069..5608880 Mycobacterium marinum M 6228855 YP_001852832.1 CDS MMAR_4572 NC_010612.1 5608885 5610816 R function unknown; probably involved in cellular metabolism, possibly in a degradation pathway; bifunctional enzyme: 2-hydroxyhepta-2,4-diene- 1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase complement(5608885..5610816) Mycobacterium marinum M 6228856 YP_001852833.1 CDS MMAR_4573 NC_010612.1 5610813 5613125 R catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; ATP-dependent DNA ligase complement(5610813..5613125) Mycobacterium marinum M 6228857 YP_001852834.1 CDS pfkB NC_010612.1 5613148 5614059 D ATP + D-fructose = ADP + D-fructose 6-phosphate; fructokinase, PfkB 5613148..5614059 Mycobacterium marinum M 6228858 YP_001852835.1 CDS MMAR_4575 NC_010612.1 5614231 5615106 D hypothetical protein 5614231..5615106 Mycobacterium marinum M 6228859 YP_001852836.1 CDS pstS2 NC_010612.1 5615161 5616279 D involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport; periplasmic phosphate-binding lipoprotein PstS2 5615161..5616279 Mycobacterium marinum M 6228860 YP_001852837.1 CDS pknD NC_010612.1 5616600 5618696 D involved in signal transduction (via phosphorylation). thought to regulate phosphate transport. can phosphorylate the peptide substrate myelin basic protein (MBP) at serine and threonine residues. can be autophosphorylated on threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 5616600..5618696 Mycobacterium marinum M 6228861 YP_001852838.1 CDS pstA1 NC_010612.1 5618704 5619606 R involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport; phosphate-transport integral membrane ABC transporter PstA1 complement(5618704..5619606) Mycobacterium marinum M 6228862 YP_001852839.1 CDS pstC2 NC_010612.1 5619603 5620577 R involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport; phosphate-transport integral membrane ABC transporter PstC2 complement(5619603..5620577) Mycobacterium marinum M 6228863 YP_001852840.1 CDS phoS2 NC_010612.1 5620590 5621702 R involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport; periplasmic phosphate-binding lipoprotein PhoS2 complement(5620590..5621702) Mycobacterium marinum M 6228864 YP_001852841.1 CDS MMAR_4581 NC_010612.1 5622036 5622827 D function unknown, possibly involved in cellular metabolism; short chain dehydrogenase 5622036..5622827 Mycobacterium marinum M 6228865 YP_001852842.1 CDS MMAR_4582 NC_010612.1 5622853 5623941 D hypothetical protein 5622853..5623941 Mycobacterium marinum M 6228866 YP_001852843.1 CDS MMAR_4583 NC_010612.1 5624053 5624787 D hypothetical protein 5624053..5624787 Mycobacterium marinum M 6228867 YP_001852844.1 CDS mntH NC_010612.1 5624867 5626093 D H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane; manganese transport protein MntH 5624867..5626093 Mycobacterium marinum M 6228868 YP_001852845.1 CDS MMAR_4585 NC_010612.1 5626259 5626588 D hypothetical protein 5626259..5626588 Mycobacterium marinum M 6228869 YP_001852846.1 CDS MMAR_4586 NC_010612.1 5626705 5627766 D hypothetical protein 5626705..5627766 Mycobacterium marinum M 6228870 YP_001852847.1 CDS MMAR_4587 NC_010612.1 5627794 5628612 D oxidoreductase 5627794..5628612 Mycobacterium marinum M 6228871 YP_001852848.1 CDS MMAR_4588 NC_010612.1 5628794 5629075 D hypothetical protein 5628794..5629075 Mycobacterium marinum M 6228873 YP_001852849.1 CDS MMAR_4589 NC_010612.1 5629088 5630521 D hypothetical protein 5629088..5630521 Mycobacterium marinum M 6228874 YP_001852850.1 CDS MMAR_4590 NC_010612.1 5630702 5631331 D hypothetical protein 5630702..5631331 Mycobacterium marinum M 6228875 YP_001852851.1 CDS MMAR_4591 NC_010612.1 5631328 5631747 D hypothetical protein 5631328..5631747 Mycobacterium marinum M 6228876 YP_001852852.1 CDS MMAR_4592 NC_010612.1 5632646 5633002 R single copy element. N-term subunit only hence element probably not functional; transposition of an insertion sequence element; transposase complement(5632646..5633002) Mycobacterium marinum M 6228877 YP_001852853.1 CDS MMAR_4595 NC_010612.1 5633945 5634241 R single copy element; transposition of an insertion sequence; transposase complement(5633945..5634241) Mycobacterium marinum M 6228879 YP_001852854.1 CDS MMAR_4596 NC_010612.1 5634468 5635451 R hypothetical protein complement(5634468..5635451) Mycobacterium marinum M 6228880 YP_001852855.1 CDS MMAR_4597 NC_010612.1 5635456 5635914 R hypothetical protein complement(5635456..5635914) Mycobacterium marinum M 6228881 YP_001852856.1 CDS MMAR_4598 NC_010612.1 5636548 5636829 D transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 5636548..5636829 Mycobacterium marinum M 6228882 YP_001852857.1 CDS MMAR_4599 NC_010612.1 5636871 5637665 D transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 5636871..5637665 Mycobacterium marinum M 6228883 YP_001852858.1 CDS MMAR_4600 NC_010612.1 5637976 5638149 R hypothetical protein complement(5637976..5638149) Mycobacterium marinum M 6228884 YP_001852859.1 CDS MMAR_4601 NC_010612.1 5638306 5639169 R hypothetical protein complement(5638306..5639169) Mycobacterium marinum M 6228885 YP_001852860.1 CDS MMAR_4602 NC_010612.1 5639613 5643368 R PE-PGRS family protein complement(5639613..5643368) Mycobacterium marinum M 6228886 YP_001852861.1 CDS MMAR_4603 NC_010612.1 5643353 5643865 R hypothetical protein complement(5643353..5643865) Mycobacterium marinum M 6228887 YP_001852862.1 CDS MMAR_4604 NC_010612.1 5643939 5644520 D single copy element; transposition of an insertion sequence. possibly IS200 family; transposase 5643939..5644520 Mycobacterium marinum M 6228888 YP_001852863.1 CDS MMAR_4605 NC_010612.1 5644363 5644866 R hypothetical protein complement(5644363..5644866) Mycobacterium marinum M 6228889 YP_001852864.1 CDS MMAR_4606 NC_010612.1 5645143 5646444 R PPE family protein complement(5645143..5646444) Mycobacterium marinum M 6228890 YP_001852865.1 CDS MMAR_4607 NC_010612.1 5647310 5648161 D hypothetical protein 5647310..5648161 Mycobacterium marinum M 6228891 YP_001852866.1 CDS MMAR_4608 NC_010612.1 5648434 5648667 D hypothetical protein 5648434..5648667 Mycobacterium marinum M 6228892 YP_001852867.1 CDS MMAR_4609 NC_010612.1 5648933 5649427 D hypothetical protein 5648933..5649427 Mycobacterium marinum M 6228893 YP_001852868.1 CDS MMAR_4610 NC_010612.1 5650087 5650887 D hypothetical protein 5650087..5650887 Mycobacterium marinum M 6228894 YP_001852869.1 CDS MMAR_4611 NC_010612.1 5651201 5651500 D PE family protein 5651201..5651500 Mycobacterium marinum M 6228895 YP_001852870.1 CDS MMAR_4612 NC_010612.1 5651509 5652777 D function unknown. possibly a protective antigen involved with the early control of infection; PPE family protein 5651509..5652777 Mycobacterium marinum M 6228896 YP_001852871.1 CDS MMAR_4613 NC_010612.1 5653031 5654266 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 5653031..5654266 Mycobacterium marinum M 6228897 YP_001852872.1 CDS MMAR_4614 NC_010612.1 5654268 5655788 D function unknown, probably involved in cellular metabolism; dioxygenase 5654268..5655788 Mycobacterium marinum M 6228898 YP_001852873.1 CDS MMAR_4615 NC_010612.1 5655805 5656278 D hypothetical protein 5655805..5656278 Mycobacterium marinum M 6228899 YP_001852874.1 CDS MMAR_4616 NC_010612.1 5656284 5656718 R hypothetical protein complement(5656284..5656718) Mycobacterium marinum M 6228900 YP_001852875.1 CDS MMAR_4617 NC_010612.1 5656789 5657562 R hypothetical protein complement(5656789..5657562) Mycobacterium marinum M 6228901 YP_001852876.1 CDS MMAR_4618 NC_010612.1 5657728 5658981 D hypothetical protein 5657728..5658981 Mycobacterium marinum M 6228902 YP_001852877.1 CDS MMAR_4619 NC_010612.1 5659093 5659539 R hypothetical protein complement(5659093..5659539) Mycobacterium marinum M 6228903 YP_001852878.1 CDS MMAR_4620 NC_010612.1 5659544 5659732 R hypothetical protein complement(5659544..5659732) Mycobacterium marinum M 6228904 YP_001852879.1 CDS MMAR_4621 NC_010612.1 5659834 5668854 R PPE family protein complement(5659834..5668854) Mycobacterium marinum M 6228905 YP_001852880.1 CDS ctpE NC_010612.1 5669219 5671594 R metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporter ATPase p-type CtpE complement(5669219..5671594) Mycobacterium marinum M 6228906 YP_001852881.1 CDS MMAR_4623 NC_010612.1 5671591 5673174 R function unknown, possibly involved in cell wall biosynthesis; penicillin binding protein complement(5671591..5673174) Mycobacterium marinum M 6228907 YP_001852882.1 CDS MMAR_4624 NC_010612.1 5673413 5674531 R hypothetical protein complement(5673413..5674531) Mycobacterium marinum M 6228908 YP_001852883.1 CDS echA6 NC_010612.1 5674538 5675269 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(5674538..5675269) Mycobacterium marinum M 6228909 YP_001852884.1 CDS accD3 NC_010612.1 5675296 5676777 D this protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [catalytic activity ATP + acetyl-CoA + HCO(3)(- ) = ADP + phosphate + malonyl-CoA]; acetyl-CoA carboxylase carboxyl transferase subunit beta 5675296..5676777 Mycobacterium marinum M 6228910 YP_001852885.1 CDS MMAR_4627 NC_010612.1 5677825 5679270 D C-term truncated 20aa.; function unknown, but maybe involved in efflux system (probably sugar or drug transport); hypothetical protein 5677825..5679270 Mycobacterium marinum M 6228911 YP_001852886.1 CDS bioF2_1 NC_010612.1 5679252 5680607 D could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase 5679252..5680607 Mycobacterium marinum M 6228912 YP_001852887.1 CDS cysM NC_010612.1 5680819 5681763 D involved in cysteine biosynthesis [catalytic activity : O3-acetyl-L-serine + H(2)S = L-cysteine + acetate]; cysteine synthase B 5680819..5681763 Mycobacterium marinum M 6228913 YP_001852888.1 CDS erg3_1 NC_010612.1 5682008 5682949 D involved in lipid desaturation; membrane-bound C-5 sterol desaturase 5682008..5682949 Mycobacterium marinum M 6228914 YP_001852889.1 CDS MMAR_4631 NC_010612.1 5683008 5683619 R involved in transcriptional mechanism; transcriptional regulatory protein complement(5683008..5683619) Mycobacterium marinum M 6228915 YP_001852890.1 CDS MMAR_4632 NC_010612.1 5683718 5685388 D proposed role in polysaccahride synthesis; putative FAD-binding dehydrogenase 5683718..5685388 Mycobacterium marinum M 6228916 YP_001852891.1 CDS prrA NC_010612.1 5685539 5686249 D transcriptional regulator part of the two-component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth; two-component response transcriptional regulatory protein PrrA 5685539..5686249 Mycobacterium marinum M 6228917 YP_001852892.1 CDS prrB NC_010612.1 5686255 5687604 D sensor part of the two-component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth; two-component sensor histidine kinase PrrB 5686255..5687604 Mycobacterium marinum M 6228918 YP_001852893.1 CDS MMAR_4635 NC_010612.1 5687624 5688262 R exported or membrane protein complement(5687624..5688262) Mycobacterium marinum M 6228919 YP_001852894.1 CDS MMAR_4636 NC_010612.1 5688262 5688495 R hypothetical protein complement(5688262..5688495) Mycobacterium marinum M 6228920 YP_001852895.1 CDS ompA NC_010612.1 5688508 5689506 R the protein behaved as a porin of low specific activity. structural protein that may protect the integrity of the bacterium; outer membrane protein OmpA complement(5688508..5689506) Mycobacterium marinum M 6228921 YP_001852896.1 CDS MMAR_4638 NC_010612.1 5689618 5689881 D hypothetical protein 5689618..5689881 Mycobacterium marinum M 6228922 YP_001852897.1 CDS MMAR_4639 NC_010612.1 5689905 5691479 D function unknown, probably involved in cellular metabolism; oxidoreductase 5689905..5691479 Mycobacterium marinum M 6228923 YP_001852898.1 CDS gltA NC_010612.1 5691484 5692779 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(5691484..5692779) Mycobacterium marinum M 6228924 YP_001852899.1 CDS MMAR_4641 NC_010612.1 5693167 5694636 R function unknown, probably involved in cellular metabolism; monooxygenase complement(5693167..5694636) Mycobacterium marinum M 6228925 YP_001852900.1 CDS pdxH NC_010612.1 5694900 5695559 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(5694900..5695559) Mycobacterium marinum M 6228926 YP_001852901.1 CDS citA NC_010612.1 5695630 5696751 D forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2 5695630..5696751 Mycobacterium marinum M 6228927 YP_001852902.1 CDS MMAR_4644 NC_010612.1 5696801 5698351 R hypothetical protein complement(5696801..5698351) Mycobacterium marinum M 6228928 YP_001852903.1 CDS MMAR_4645 NC_010612.1 5699795 5700253 D hypothetical protein 5699795..5700253 Mycobacterium marinum M 6228929 YP_001852904.1 CDS fprB NC_010612.1 5700330 5702015 R serves as the first electron transfer protein in all the P450 systems [catalytic activity: reduced adrenodoxin + NADP+ = oxidized adrenodoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprB complement(5700330..5702015) Mycobacterium marinum M 6228930 YP_001852905.1 CDS MMAR_4647 NC_010612.1 5702034 5703059 R hypothetical protein complement(5702034..5703059) Mycobacterium marinum M 6228931 YP_001852906.1 CDS serC NC_010612.1 5703266 5704396 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 5703266..5704396 Mycobacterium marinum M 6228932 YP_001852907.1 CDS MMAR_4649 NC_010612.1 5704518 5705309 D hypothetical protein 5704518..5705309 Mycobacterium marinum M 6228933 YP_001852908.1 CDS MMAR_4650 NC_010612.1 5705306 5705593 R transmembrane protein complement(5705306..5705593) Mycobacterium marinum M 6228934 YP_001852909.1 CDS MMAR_4651 NC_010612.1 5705590 5706429 R causes methylation; rRNA methyltransferase complement(5705590..5706429) Mycobacterium marinum M 6228935 YP_001852910.1 CDS MMAR_4652 NC_010612.1 5706426 5706713 R thought to be involved in transcriptional mechanism; MarR family transcriptional regulator complement(5706426..5706713) Mycobacterium marinum M 6228936 YP_001852911.1 CDS MMAR_4653 NC_010612.1 5707116 5707403 D transmembrane protein 5707116..5707403 Mycobacterium marinum M 6228937 YP_001852912.1 CDS MMAR_4654 NC_010612.1 5707424 5707879 D hypothetical protein 5707424..5707879 Mycobacterium marinum M 6228938 YP_001852913.1 CDS MMAR_4655 NC_010612.1 5707876 5708679 R hypothetical protein complement(5707876..5708679) Mycobacterium marinum M 6228939 YP_001852914.1 CDS MMAR_4656 NC_010612.1 5708785 5710494 D transmembrane protein 5708785..5710494 Mycobacterium marinum M 6228940 YP_001852915.1 CDS MMAR_4657 NC_010612.1 5710491 5710979 D hypothetical protein 5710491..5710979 Mycobacterium marinum M 6228941 YP_001852916.1 CDS MMAR_4658 NC_010612.1 5711088 5711942 D hypothetical protein 5711088..5711942 Mycobacterium marinum M 6228942 YP_001852917.1 CDS MMAR_4659 NC_010612.1 5711939 5712943 R hypothetical protein complement(5711939..5712943) Mycobacterium marinum M 6228943 YP_001852918.1 CDS fadE10 NC_010612.1 5712956 5714908 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE10 complement(5712956..5714908) Mycobacterium marinum M 6228944 YP_001852919.1 CDS cspB NC_010612.1 5715096 5715500 R function unknown; thought to act in response to low temperature; cold shock-like protein B CspB complement(5715096..5715500) Mycobacterium marinum M 6228945 YP_001852920.1 CDS MMAR_4662 NC_010612.1 5715664 5716068 D hypothetical protein 5715664..5716068 Mycobacterium marinum M 6228946 YP_001852921.1 CDS moaA NC_010612.1 5716065 5717147 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 5716065..5717147 Mycobacterium marinum M 6228947 YP_001852922.1 CDS moaD2 NC_010612.1 5717161 5717430 D involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein D 2 MoaD2 5717161..5717430 Mycobacterium marinum M 6228948 YP_001852923.1 CDS rpfA NC_010612.1 5717866 5719023 D function unknown. may be promote the resuscitation and growth of dormant, nongrowing cell; resuscitation-promoting factor RpfA 5717866..5719023 Mycobacterium marinum M 6228949 YP_001852924.1 CDS moaE2 NC_010612.1 5719068 5719493 R possibly a molybdenum biosynthesis cofactor. conversion of molybdopterin precursor Z into molybdopterin requires transfer of two sulfur atoms to precursor Z (to generate the dithiolene group). this is catalyzed by the converting factor composed of a small and large subunit; molybdenum cofactor biosynthesis protein E2 MoaE2 complement(5719068..5719493) Mycobacterium marinum M 6228950 YP_001852925.1 CDS mog NC_010612.1 5719490 5719975 R involved in molybdopterin biosynthesis; involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes; molybdopterin biosynthesis Mog protein complement(5719490..5719975) Mycobacterium marinum M 6228951 YP_001852926.1 CDS moaC2 NC_010612.1 5719972 5720508 R involved in the biosynthesis of molybdopterin; molybdenum cofactor biosynthesis protein C 2 MoaC2 complement(5719972..5720508) Mycobacterium marinum M 6228952 YP_001852927.1 CDS MMAR_4669 NC_010612.1 5720517 5720726 R hypothetical protein complement(5720517..5720726) Mycobacterium marinum M 6228953 YP_001852928.1 CDS MMAR_4670 NC_010612.1 5720789 5723047 D hypothetical protein 5720789..5723047 Mycobacterium marinum M 6228954 YP_001852929.1 CDS ercc3 NC_010612.1 5723130 5724779 D involved in nucleotide excision repair. has helicase activity: acts by opening DNA either around the RNA transcription start site or the DNA damage; DNA helicase Ercc3 5723130..5724779 Mycobacterium marinum M 6228955 YP_001852930.1 CDS MMAR_5545 NC_010612.1 5724891 5725328 R hypothetical protein complement(5724891..5725328) Mycobacterium marinum M 6228956 YP_001852931.1 CDS MMAR_4672 NC_010612.1 5725630 5725950 D hypothetical protein 5725630..5725950 Mycobacterium marinum M 6228957 YP_001852932.1 CDS MMAR_4673 NC_010612.1 5725977 5726960 R function unknown, may have reductase activity; hypothetical protein complement(5725977..5726960) Mycobacterium marinum M 6228958 YP_001852933.1 CDS MMAR_4674 NC_010612.1 5727030 5727566 R transcriptional regulator complement(5727030..5727566) Mycobacterium marinum M 6228959 YP_001852934.1 CDS MMAR_4675 NC_010612.1 5727646 5728857 D membrane-associated oxidoreductase 5727646..5728857 Mycobacterium marinum M 6228960 YP_001852935.1 CDS fadB NC_010612.1 5728932 5731076 R involved in fatty acid degradation (probably in fatty acid beta-oxidation cycle); fatty oxidation protein FadB complement(5728932..5731076) Mycobacterium marinum M 6228961 YP_001852936.1 CDS fadA NC_010612.1 5731081 5732334 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(5731081..5732334) Mycobacterium marinum M 6228962 YP_001852937.1 CDS MMAR_4678 NC_010612.1 5732496 5733692 D function unknown, probably involved in cellular metabolism; aminotransferase 5732496..5733692 Mycobacterium marinum M 6228963 YP_001852938.1 CDS MMAR_4679 NC_010612.1 5733689 5734150 R hypothetical protein complement(5733689..5734150) Mycobacterium marinum M 6228964 YP_001852939.1 CDS MMAR_4680 NC_010612.1 5734176 5734640 R hypothetical protein complement(5734176..5734640) Mycobacterium marinum M 6228965 YP_001852940.1 CDS far NC_010612.1 5734690 5735769 R function unknown, but involvement in lipid degradation (racemization); fatty-acid-CoA racemase Far complement(5734690..5735769) Mycobacterium marinum M 6228966 YP_001852941.1 CDS MMAR_4682 NC_010612.1 5735779 5736219 R conserved hypothetical protein; hypothetical protein complement(5735779..5736219) Mycobacterium marinum M 6228967 YP_001852942.1 CDS pdc NC_010612.1 5736283 5737983 D possible indole-3-pyruvate decarboxylase; [catalytic activity: 3-(indol-3-YL) pyruvate = 2-(indol-3- YL)acetaldehyde + CO2], or possible pyruvate decarboxylase; [catalytic activity: a 2-OXO acid = an aldehyde + CO2]; pyruvate or indole-3-pyruvate decarboxylase Pdc 5736283..5737983 Mycobacterium marinum M 6228968 YP_001852943.1 CDS MMAR_4684 NC_010612.1 5737998 5738183 R conserved hypothetical protein; hypothetical protein complement(5737998..5738183) Mycobacterium marinum M 6228969 YP_001852944.1 CDS fadD16 NC_010612.1 5738197 5738826 R function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD16 complement(5738197..5738826) Mycobacterium marinum M 6228970 YP_001852945.1 CDS MMAR_4686 NC_010612.1 5738878 5739459 R hypothetical protein complement(5738878..5739459) Mycobacterium marinum M 6228971 YP_001852946.1 CDS MMAR_4687 NC_010612.1 5739456 5740439 R hypothetical protein complement(5739456..5740439) Mycobacterium marinum M 6228972 YP_001852947.1 CDS fadD3_2 NC_010612.1 5740712 5742151 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(5740712..5742151) Mycobacterium marinum M 6228973 YP_001852948.1 CDS MMAR_4689 NC_010612.1 5742148 5743329 R function unknown, contains a hydrolytic domain; hypothetical protein complement(5742148..5743329) Mycobacterium marinum M 6228974 YP_001852949.1 CDS MMAR_4690 NC_010612.1 5743423 5743845 R lipoprotein complement(5743423..5743845) Mycobacterium marinum M 6228975 YP_001852950.1 CDS echA8_2 NC_010612.1 5743989 5744753 D oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_2 5743989..5744753 Mycobacterium marinum M 6228976 YP_001852951.1 CDS MMAR_4692 NC_010612.1 5744750 5745181 D hypothetical protein 5744750..5745181 Mycobacterium marinum M 6228977 YP_001852952.1 CDS MMAR_4693 NC_010612.1 5745184 5745768 R involved in transcriptional mechanism; transcriptional regulator complement(5745184..5745768) Mycobacterium marinum M 6228978 YP_001852953.1 CDS cyp150A6 NC_010612.1 5745928 5747202 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 150A6 Cyp150A6 5745928..5747202 Mycobacterium marinum M 6228979 YP_001852954.1 CDS MMAR_4695 NC_010612.1 5747221 5747511 R hypothetical protein complement(5747221..5747511) Mycobacterium marinum M 6228980 YP_001852955.1 CDS MMAR_4696 NC_010612.1 5747515 5748120 R function unknown role in electron transport; cytochrome C oxidase subunit III complement(5747515..5748120) Mycobacterium marinum M 6228981 YP_001852956.1 CDS MMAR_4697 NC_010612.1 5748117 5748929 R hypothetical protein complement(5748117..5748929) Mycobacterium marinum M 6228982 YP_001852957.1 CDS MMAR_4698 NC_010612.1 5748932 5749681 R hypothetical protein complement(5748932..5749681) Mycobacterium marinum M 6228983 YP_001852958.1 CDS MMAR_4699 NC_010612.1 5749769 5750350 D transcriptional regulatory protein 5749769..5750350 Mycobacterium marinum M 6228984 YP_001852959.1 CDS MMAR_4700 NC_010612.1 5750550 5750840 D hypothetical protein 5750550..5750840 Mycobacterium marinum M 6228985 YP_001852960.1 CDS MMAR_4701 NC_010612.1 5750867 5751283 R hypothetical protein complement(5750867..5751283) Mycobacterium marinum M 6228986 YP_001852961.1 CDS MMAR_4702 NC_010612.1 5751435 5752169 D hypothetical protein 5751435..5752169 Mycobacterium marinum M 6228987 YP_001852962.1 CDS MMAR_4703 NC_010612.1 5752166 5752696 D hypothetical protein 5752166..5752696 Mycobacterium marinum M 6228988 YP_001852963.1 CDS MMAR_4704 NC_010612.1 5752798 5753301 D hypothetical protein 5752798..5753301 Mycobacterium marinum M 6228989 YP_001852964.1 CDS MMAR_4705 NC_010612.1 5753337 5754968 R function unknown, but thought involved in host cell invasion; MCE-family protein complement(5753337..5754968) Mycobacterium marinum M 6228990 YP_001852965.1 CDS MMAR_4706 NC_010612.1 5754969 5756201 R function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein complement(5754969..5756201) Mycobacterium marinum M 6228991 YP_001852966.1 CDS MMAR_4707 NC_010612.1 5756198 5757625 R function unknown, but thought to be involved in host cell invasion; MCE-family protein complement(5756198..5757625) Mycobacterium marinum M 6228992 YP_001852967.1 CDS MMAR_4708 NC_010612.1 5757622 5758704 R function unknown, but thought to be involved in host cell invasion; MCE-family protein complement(5757622..5758704) Mycobacterium marinum M 6228993 YP_001852968.1 CDS MMAR_4709 NC_010612.1 5758697 5759728 R function unknown, but thought to be involved in host cell invasion; MCE-family protein complement(5758697..5759728) Mycobacterium marinum M 6228994 YP_001852969.1 CDS MMAR_4710 NC_010612.1 5759725 5761002 R function unknown, but thought to be involved in host cell invasion; MCE-family protein complement(5759725..5761002) Mycobacterium marinum M 6228995 YP_001852970.1 CDS MMAR_4711 NC_010612.1 5761022 5761867 R hypothetical protein complement(5761022..5761867) Mycobacterium marinum M 6228996 YP_001852971.1 CDS MMAR_4712 NC_010612.1 5761910 5762716 R hypothetical protein complement(5761910..5762716) Mycobacterium marinum M 6228997 YP_001852972.1 CDS MMAR_4713 NC_010612.1 5763034 5764239 R dehydratase complement(5763034..5764239) Mycobacterium marinum M 6228998 YP_001852973.1 CDS MMAR_4714 NC_010612.1 5764236 5765780 R oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD-dependent aldehyde dehydrogenase complement(5764236..5765780) Mycobacterium marinum M 6228999 YP_001852974.1 CDS MMAR_4715 NC_010612.1 5766071 5766772 D involved in the fatty acid biosynthesis [catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH]; 3-oxoacyl-ACP reductase 5766071..5766772 Mycobacterium marinum M 6229000 YP_001852975.1 CDS MMAR_4716 NC_010612.1 5766881 5767081 D ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin 5766881..5767081 Mycobacterium marinum M 6229001 YP_001852976.1 CDS cyp188A3 NC_010612.1 5767096 5768460 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 188A3 Cyp188A3 5767096..5768460 Mycobacterium marinum M 6229002 YP_001852977.1 CDS MMAR_4718 NC_010612.1 5768561 5769736 R function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase complement(5768561..5769736) Mycobacterium marinum M 6229003 YP_001852978.1 CDS MMAR_4719 NC_010612.1 5769720 5770718 R function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase complement(5769720..5770718) Mycobacterium marinum M 6229004 YP_001852979.1 CDS MMAR_4720 NC_010612.1 5770820 5771320 D hypothetical protein 5770820..5771320 Mycobacterium marinum M 6229005 YP_001852980.1 CDS MMAR_4721 NC_010612.1 5771483 5772097 R function unknown; probably involved in cellular metabolism; nitroreductase complement(5771483..5772097) Mycobacterium marinum M 6229006 YP_001852981.1 CDS plcB_6 NC_010612.1 5772382 5773938 D hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 5772382..5773938 Mycobacterium marinum M 6229007 YP_001852982.1 CDS MMAR_4723 NC_010612.1 5774113 5774580 D hypothetical protein 5774113..5774580 Mycobacterium marinum M 6229008 YP_001852983.1 CDS MMAR_4724 NC_010612.1 5774873 5775976 D metal-dependent hydrolase 5774873..5775976 Mycobacterium marinum M 6229009 YP_001852984.1 CDS MMAR_4725 NC_010612.1 5776024 5777169 D metal-dependent hydrolase 5776024..5777169 Mycobacterium marinum M 6229010 YP_001852985.1 CDS MMAR_4726 NC_010612.1 5777171 5777563 D could as ferredoxin subunits of nitrite reductase; hypothetical protein 5777171..5777563 Mycobacterium marinum M 6229011 YP_001852986.1 CDS MMAR_4727 NC_010612.1 5777560 5778447 D hydrolase 5777560..5778447 Mycobacterium marinum M 6229012 YP_001852987.1 CDS MMAR_4728 NC_010612.1 5778462 5778935 R hypothetical protein complement(5778462..5778935) Mycobacterium marinum M 6229013 YP_001852988.1 CDS nuoF_1 NC_010612.1 5778988 5780325 D involved in aerobic|anaerobic respiration [catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol]; NADH dehydrogenase I subunit F 5778988..5780325 Mycobacterium marinum M 6229014 YP_001852989.1 CDS MMAR_4730 NC_010612.1 5780322 5780618 D required for electron transfer; ferredoxin 5780322..5780618 Mycobacterium marinum M 6229015 YP_001852990.1 CDS MMAR_4731 NC_010612.1 5780754 5782409 D function unknown, supposed involvement in lipid metabolism. may have specificity for branched-chain acyl CoAs; 3-ketoacyl-CoA thiolase 5780754..5782409 Mycobacterium marinum M 6229016 YP_001852991.1 CDS MMAR_4732 NC_010612.1 5782406 5783308 D ensuring efficient processing by acyl-synthase machinery E.G. PKS; thioesterase 5782406..5783308 Mycobacterium marinum M 6229017 YP_001852992.1 CDS cyp190A3 NC_010612.1 5783436 5784638 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 190A3 Cyp190A3 5783436..5784638 Mycobacterium marinum M 6229018 YP_001852993.1 CDS fdxD_2 NC_010612.1 5784649 5784840 D ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxD 5784649..5784840 Mycobacterium marinum M 6229019 YP_001852994.1 CDS MMAR_4735 NC_010612.1 5785047 5786729 D PE-PGRS family protein 5785047..5786729 Mycobacterium marinum M 6229020 YP_001852995.1 CDS MMAR_4736 NC_010612.1 5786777 5786965 R ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin complement(5786777..5786965) Mycobacterium marinum M 6229021 YP_001852996.1 CDS cyp150A5 NC_010612.1 5786962 5788233 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 150A5 Cyp150A5 complement(5786962..5788233) Mycobacterium marinum M 6229022 YP_001852997.1 CDS MMAR_4738 NC_010612.1 5788342 5788845 R hypothetical protein complement(5788342..5788845) Mycobacterium marinum M 6229023 YP_001852998.1 CDS MMAR_4739 NC_010612.1 5788842 5789447 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(5788842..5789447) Mycobacterium marinum M 6229024 YP_001852999.1 CDS fadA6_2 NC_010612.1 5789551 5790711 R function unknown, but involved in lipid degradation [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]; acetyl-CoA acetyltransferase complement(5789551..5790711) Mycobacterium marinum M 6229025 YP_001853000.1 CDS fadE12_1 NC_010612.1 5790807 5791973 R function unknown, but involved in lipid metabolism; acyl-CoA dehydrogenase FadE12 complement(5790807..5791973) Mycobacterium marinum M 6229026 YP_001853001.1 CDS MMAR_4742 NC_010612.1 5792084 5793382 R function unknown role in cellular metabolism; metal-dependent amidohydrolase complement(5792084..5793382) Mycobacterium marinum M 6229027 YP_001853002.1 CDS MMAR_4743 NC_010612.1 5793711 5794259 D hypothetical protein 5793711..5794259 Mycobacterium marinum M 6229028 YP_001853003.1 CDS MMAR_4744 NC_010612.1 5794267 5795547 D function unknown; involved in cellular metabolism; dioxygenase 5794267..5795547 Mycobacterium marinum M 6229029 YP_001853004.1 CDS MMAR_4745 NC_010612.1 5795531 5795866 D hypothetical protein 5795531..5795866 Mycobacterium marinum M 6229030 YP_001853005.1 CDS MMAR_4746 NC_010612.1 5795870 5797090 D imidazolonepropionase is an amidohydrolase; imidazolonepropionase 5795870..5797090 Mycobacterium marinum M 6229031 YP_001853006.1 CDS MMAR_4747 NC_010612.1 5797074 5797493 D hypothetical protein 5797074..5797493 Mycobacterium marinum M 6229032 YP_001853007.1 CDS MMAR_4748 NC_010612.1 5797490 5798599 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 5797490..5798599 Mycobacterium marinum M 6229033 YP_001853008.1 CDS MMAR_4749 NC_010612.1 5798620 5799438 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 5798620..5799438 Mycobacterium marinum M 6229034 YP_001853009.1 CDS MMAR_4750 NC_010612.1 5799569 5801041 R function unknown, possibly involved in transport of sulfate across the membrane; integral membrane transporter complement(5799569..5801041) Mycobacterium marinum M 6229035 YP_001853010.1 CDS MMAR_4751 NC_010612.1 5801405 5802592 R function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase complement(5801405..5802592) Mycobacterium marinum M 6229036 YP_001853011.1 CDS MMAR_4752 NC_010612.1 5802783 5803436 D could be involved in transcriptional mechanism; transcriptional regulatory protein 5802783..5803436 Mycobacterium marinum M 6229037 YP_001853012.1 CDS cyp189A7 NC_010612.1 5803670 5804872 D cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 189A7 Cyp189A7 5803670..5804872 Mycobacterium marinum M 6229038 YP_001853013.1 CDS MMAR_4754 NC_010612.1 5804903 5805754 D function unknown; possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 5804903..5805754 Mycobacterium marinum M 6229039 YP_001853014.1 CDS MMAR_4755 NC_010612.1 5805766 5806596 D function unknown, possibly involved in cellular metabolism; short chain dehydrogenase 5805766..5806596 Mycobacterium marinum M 6229040 YP_001853015.1 CDS MMAR_4756 NC_010612.1 5806593 5807399 R function unknown, probably involved in cellular metabolism; oxidoreductase complement(5806593..5807399) Mycobacterium marinum M 6229041 YP_001853016.1 CDS MMAR_4757 NC_010612.1 5807408 5809846 R acyl-CoA transferase complement(5807408..5809846) Mycobacterium marinum M 6229042 YP_001853017.1 CDS echA4_1 NC_010612.1 5809846 5810838 R oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA4 complement(5809846..5810838) Mycobacterium marinum M 6229043 YP_001853018.1 CDS MMAR_4759 NC_010612.1 5810841 5811959 R function unknown, hydrolyses peptides; aminopeptidase complement(5810841..5811959) Mycobacterium marinum M 6229044 YP_001853019.1 CDS MMAR_4760 NC_010612.1 5811949 5813184 R hydrolysis of peptide bonds; dipeptidase complement(5811949..5813184) Mycobacterium marinum M 6229045 YP_001853020.1 CDS MMAR_4761 NC_010612.1 5813194 5814366 R hypothetical protein complement(5813194..5814366) Mycobacterium marinum M 6229046 YP_001853021.1 CDS cyp105Q4 NC_010612.1 5814404 5815648 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 105Q4 Cyp105Q4 complement(5814404..5815648) Mycobacterium marinum M 6229047 YP_001853022.1 CDS MMAR_4763 NC_010612.1 5815651 5815845 R ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin complement(5815651..5815845) Mycobacterium marinum M 6229048 YP_001853023.1 CDS MMAR_4764 NC_010612.1 5815858 5816523 R function unknown, maybe a transcriptional regulator; hypothetical protein complement(5815858..5816523) Mycobacterium marinum M 6229049 YP_001853024.1 CDS MMAR_4765 NC_010612.1 5816612 5817415 R short chain dehydrogenase complement(5816612..5817415) Mycobacterium marinum M 6229050 YP_001853025.1 CDS MMAR_4766 NC_010612.1 5817610 5818362 D function unknown; domain homology to nucleoside- diphosphate-sugar epimerases; hypothetical protein 5817610..5818362 Mycobacterium marinum M 6229051 YP_001853026.1 CDS MMAR_4767 NC_010612.1 5818415 5819692 R thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane; integral membrane transport protein complement(5818415..5819692) Mycobacterium marinum M 6229052 YP_001853027.1 CDS cysK2 NC_010612.1 5819692 5820912 R thought to be involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L- cysteine + acetate]; cysteine synthase a CysK2 complement(5819692..5820912) Mycobacterium marinum M 6229053 YP_001853028.1 CDS lpqS NC_010612.1 5821016 5821432 R lipoprotein LpqS complement(5821016..5821432) Mycobacterium marinum M 6229054 YP_001853029.1 CDS MMAR_4770 NC_010612.1 5821553 5823211 D probable oxidase, showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins; oxidase 5821553..5823211 Mycobacterium marinum M 6229055 YP_001853030.1 CDS MMAR_4771 NC_010612.1 5823242 5824060 R function unknown, predicted hydrolase or acyltransferase domain; hypothetical protein complement(5823242..5824060) Mycobacterium marinum M 6229056 YP_001853031.1 CDS MMAR_4772 NC_010612.1 5824060 5825049 R putative cyclase; hypothetical protein complement(5824060..5825049) Mycobacterium marinum M 6229057 YP_001853032.1 CDS MMAR_4773 NC_010612.1 5825049 5825864 R catalyzes the formation of 5-alpha-androstane-3,17-dione from androsterone; Acts on other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin.; 3-alpha-hydroxysteroid dehydrogenase complement(5825049..5825864) Mycobacterium marinum M 6229058 YP_001853033.1 CDS MMAR_4774 NC_010612.1 5825899 5827200 R monoxygenase complement(5825899..5827200) Mycobacterium marinum M 6229059 YP_001853034.1 CDS MMAR_4775 NC_010612.1 5827203 5828957 R initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase complement(5827203..5828957) Mycobacterium marinum M 6229060 YP_001853035.1 CDS mhpB NC_010612.1 5828954 5829874 R catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase complement(5828954..5829874) Mycobacterium marinum M 6229061 YP_001853036.1 CDS mhpA NC_010612.1 5829822 5831537 R catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase complement(5829822..5831537) Mycobacterium marinum M 6229062 YP_001853037.1 CDS bphD_1 NC_010612.1 5831537 5832403 R involved in the degradation of biphenyl; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase complement(5831537..5832403) Mycobacterium marinum M 6229063 YP_001853038.1 CDS MMAR_4779 NC_010612.1 5832532 5833209 D involved in transcriptional mechanism; transcriptional regulatory protein 5832532..5833209 Mycobacterium marinum M 6229064 YP_001853039.1 CDS MMAR_4780 NC_010612.1 5833224 5834837 D dehydrogenase 5833224..5834837 Mycobacterium marinum M 6229065 YP_001853040.1 CDS MMAR_4781 NC_010612.1 5834844 5836061 R possible sensor part of a two-component regulatory system; two-component sensor kinase complement(5834844..5836061) Mycobacterium marinum M 6229066 YP_001853041.1 CDS narL NC_010612.1 5836286 5836936 D nitrate/nitrite response regulator protein NarL 5836286..5836936 Mycobacterium marinum M 6229067 YP_001853042.1 CDS MMAR_4783 NC_010612.1 5836881 5838422 R possible sensor part of a two-component regulatory system; two-component sensor kinase complement(5836881..5838422) Mycobacterium marinum M 6229068 YP_001853043.1 CDS MMAR_4784 NC_010612.1 5838406 5839320 R dehydrogenase complement(5838406..5839320) Mycobacterium marinum M 6229069 YP_001853044.1 CDS MMAR_4785 NC_010612.1 5839552 5840865 R integral membrane protein complement(5839552..5840865) Mycobacterium marinum M 6229070 YP_001853045.1 CDS MMAR_4786 NC_010612.1 5841215 5841514 R PE-PGRS family protein complement(5841215..5841514) Mycobacterium marinum M 6229071 YP_001853046.1 CDS MMAR_4787 NC_010612.1 5841603 5842481 R transport system kinase - possibly arginine; transport system kinase complement(5841603..5842481) Mycobacterium marinum M 6229072 YP_001853047.1 CDS MMAR_4788 NC_010612.1 5842499 5843650 R function unknown but may be involved in fatty acid oxidation (beta oxidation); beta-ketoacyl CoA thiolase complement(5842499..5843650) Mycobacterium marinum M 6229073 YP_001853048.1 CDS pip NC_010612.1 5843765 5844631 D specifically catalyzes the removal of N-terminal proline residues from peptides. thought to release the N- terminal proline from the dipeptides, pro-pro, pro-gln, pro-trp and pro-tyr; also from amides (pro-beta na) and oligopeptides, pro-leu-glynH2, pro-leu-gly and pro-phe-gly- lys. higher activity toward small peptides (up to three residues), but very low activity for longer peptides [catalytic activity: release of a N-terminal proline from a peptide]; proline iminopeptidase Pip 5843765..5844631 Mycobacterium marinum M 6229074 YP_001853049.1 CDS MMAR_4790 NC_010612.1 5844660 5845427 R lipid metabolism; enoyl-CoA hydratase complement(5844660..5845427) Mycobacterium marinum M 6229075 YP_001853050.1 CDS MMAR_4791 NC_010612.1 5845429 5846526 R involved in lipid metabolism; acyl-CoA dehydrogenase complement(5845429..5846526) Mycobacterium marinum M 6229076 YP_001853051.1 CDS MMAR_4792 NC_010612.1 5846513 5847418 R involved in lipid metabolism; acyl-CoA dehydrogenase complement(5846513..5847418) Mycobacterium marinum M 6229077 YP_001853052.1 CDS MMAR_4793 NC_010612.1 5847396 5848799 R acyl-CoA synthetase complement(5847396..5848799) Mycobacterium marinum M 6229078 YP_001853053.1 CDS MMAR_4794 NC_010612.1 5848915 5849196 D similar to ferredoxin reductase electron transfer proteins; electron transfer protein 5848915..5849196 Mycobacterium marinum M 6229079 YP_001853054.1 CDS MMAR_4795 NC_010612.1 5849226 5850266 R acyl-CoA transferase complement(5849226..5850266) Mycobacterium marinum M 6229080 YP_001853055.1 CDS MMAR_4796 NC_010612.1 5850263 5851219 R oxidoreductase complement(5850263..5851219) Mycobacterium marinum M 6229081 YP_001853056.1 CDS mcmA2b NC_010612.1 5851204 5851641 R involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity : (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA.]; methylmalonyl-CoA mutase subunit alpha, McmA2b complement(5851204..5851641) Mycobacterium marinum M 6229082 YP_001853057.1 CDS mcmA2a NC_010612.1 5851642 5853219 R catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [catalytic activity : (R)-2-methyl-3-oxopropanoyl-CoA = succinyl- CoA.]. the enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. the enzyme induces the formation of an adenosyl radical from the cofactor. this radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA; methylmalonyl-CoA mutase beta subunit, McmA2a complement(5851642..5853219) Mycobacterium marinum M 6229083 YP_001853058.1 CDS MMAR_4799 NC_010612.1 5853344 5854156 R possible methylase; hypothetical protein complement(5853344..5854156) Mycobacterium marinum M 6229084 YP_001853059.1 CDS lpqR NC_010612.1 5854217 5855002 R lipoprotein LpqR complement(5854217..5855002) Mycobacterium marinum M 6229085 YP_001853060.1 CDS MMAR_4801 NC_010612.1 5855113 5855703 D hypothetical protein 5855113..5855703 Mycobacterium marinum M 6229086 YP_001853061.1 CDS MMAR_4802 NC_010612.1 5855725 5856579 D contains a N-term cellobiohydrolase a (1,4-beta- cellobiosidase a) domain and a C-term cellulose-binding domain (CBD) domain. the CBD is found either at the N-term or at the C-terminal extremity of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases; chitinase/cellulase 5855725..5856579 Mycobacterium marinum M 6229087 YP_001853062.1 CDS MMAR_4803 NC_010612.1 5856598 5856888 R transmembrane protein; hypothetical protein complement(5856598..5856888) Mycobacterium marinum M 6229088 YP_001853063.1 CDS MMAR_4804 NC_010612.1 5856885 5857190 R function unknown; possible role in carotenoid pigment biosynthesis given linkage to CrtI and CrtB; hypothetical protein complement(5856885..5857190) Mycobacterium marinum M 6229089 YP_001853064.1 CDS crtE NC_010612.1 5857600 5858754 D converts farensyl pyrophosphate to geranylgeranyl pyrophosphate, the latter being the substrate for CrtB in the production of phytoene during carotenoid synthesis; geranylgeranyl pyrophosphate synthase 5857600..5858754 Mycobacterium marinum M 6229090 YP_001853065.1 CDS crtI NC_010612.1 5858779 5860308 D part of carotenoid biosynthesis cluster; phytoene dehydrogenase CrtI 5858779..5860308 Mycobacterium marinum M 6229091 YP_001853066.1 CDS crtB NC_010612.1 5860305 5861264 D part of carotenoid biosynthesis cluster - photochromogenesis; phytoene synthase, CrtB 5860305..5861264 Mycobacterium marinum M 6229092 YP_001853067.1 CDS crtYc NC_010612.1 5861261 5861584 D involved in carotenoid biosynthesis; lycopene cyclase, CrtYc 5861261..5861584 Mycobacterium marinum M 6229093 YP_001853068.1 CDS crtYd NC_010612.1 5861581 5861955 D involved in carotenoid biosynthesis; lycopene cyclase, CrtYd 5861581..5861955 Mycobacterium marinum M 6229094 YP_001853069.1 CDS mmpL13_1 NC_010612.1 5861949 5864258 D function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL 5861949..5864258 Mycobacterium marinum M 6229095 YP_001853070.1 CDS MMAR_4811 NC_010612.1 5864308 5864859 D involved in transcriptional mechanism; MarR family transcriptional regulator 5864308..5864859 Mycobacterium marinum M 6229096 YP_001853071.1 CDS idi2 NC_010612.1 5864869 5865915 R catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase complement(5864869..5865915) Mycobacterium marinum M 6229097 YP_001853072.1 CDS MMAR_4813 NC_010612.1 5866032 5866739 R hypothetical protein complement(5866032..5866739) Mycobacterium marinum M 6229098 YP_001853073.1 CDS MMAR_4814 NC_010612.1 5866733 5867335 R hypothetical protein complement(5866733..5867335) Mycobacterium marinum M 6229099 YP_001853074.1 CDS ansP1 NC_010612.1 5867417 5868901 R involved in L-asparagine transport; L-asparagine permease AnsP1 complement(5867417..5868901) Mycobacterium marinum M 6229100 YP_001853075.1 CDS MMAR_4816 NC_010612.1 5868945 5869187 R hypothetical protein complement(5868945..5869187) Mycobacterium marinum M 6229101 YP_001853076.1 CDS MMAR_4817 NC_010612.1 5869377 5869937 R function unknown, predicted ATPase domain; hypothetical protein complement(5869377..5869937) Mycobacterium marinum M 6229102 YP_001853077.1 CDS MMAR_4818 NC_010612.1 5870113 5871063 D probable dehydrogenase; hypothetical protein 5870113..5871063 Mycobacterium marinum M 6229103 YP_001853078.1 CDS MMAR_4819 NC_010612.1 5871060 5871875 D hypothetical protein 5871060..5871875 Mycobacterium marinum M 6229104 YP_001853079.1 CDS MMAR_4820 NC_010612.1 5871878 5873092 D contains amidohydrolase domain; hypothetical protein 5871878..5873092 Mycobacterium marinum M 6229105 YP_001853080.1 CDS MMAR_4821 NC_010612.1 5873107 5874402 D function unknown; contains amidohydrolase domain; hypothetical protein 5873107..5874402 Mycobacterium marinum M 6229106 YP_001853081.1 CDS MMAR_4822 NC_010612.1 5874700 5876571 D PE-PGRS family protein 5874700..5876571 Mycobacterium marinum M 6229107 YP_001853082.1 CDS cspA NC_010612.1 5876841 5877044 R possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures); cold shock protein a, CspA complement(5876841..5877044) Mycobacterium marinum M 6229108 YP_001853083.1 CDS rhlE1 NC_010612.1 5877137 5878711 R function unknown, possibly involved in ATP- dependent RNA unwinding, enzymes of this class are needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation; ATP-dependent RNA helicase, RhlE1 complement(5877137..5878711) Mycobacterium marinum M 6229109 YP_001853084.1 CDS MMAR_5579 NC_010612.1 5878927 5879061 D hypothetical protein 5878927..5879061 Mycobacterium marinum M 6229110 YP_001853085.1 CDS metH NC_010612.1 5879550 5883284 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 5879550..5883284 Mycobacterium marinum M 6229111 YP_001853086.1 CDS MMAR_4826 NC_010612.1 5883692 5884360 D contains a nucleotidyltransferase domain; hypothetical protein 5883692..5884360 Mycobacterium marinum M 6229112 YP_001853087.1 CDS MMAR_4827 NC_010612.1 5884360 5884785 D hypothetical protein 5884360..5884785 Mycobacterium marinum M 6229113 YP_001853088.1 CDS MMAR_4828 NC_010612.1 5885265 5886767 D hypothetical protein 5885265..5886767 Mycobacterium marinum M 6229114 YP_001853089.1 CDS MMAR_4829 NC_010612.1 5886746 5887186 R hypothetical protein complement(5886746..5887186) Mycobacterium marinum M 6229115 YP_001853090.1 CDS MMAR_4830 NC_010612.1 5887386 5888039 D hypothetical protein 5887386..5888039 Mycobacterium marinum M 6229116 YP_001853091.1 CDS MMAR_4831 NC_010612.1 5888093 5888434 D hypothetical protein 5888093..5888434 Mycobacterium marinum M 6229117 YP_001853092.1 CDS MMAR_4832 NC_010612.1 5888860 5889441 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(5888860..5889441) Mycobacterium marinum M 6229118 YP_001853093.1 CDS cyp123B1 NC_010612.1 5889490 5890701 D cytochrome P450s are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 123B1 Cyp123B1 5889490..5890701 Mycobacterium marinum M 6229119 YP_001853094.1 CDS MMAR_4834 NC_010612.1 5890714 5891400 R possibly involved in a transcriptional mechanism; TetR family transcriptional regulator complement(5890714..5891400) Mycobacterium marinum M 6229120 YP_001853095.1 CDS MMAR_4835 NC_010612.1 5891628 5891957 D hypothetical protein 5891628..5891957 Mycobacterium marinum M 6229121 YP_001853096.1 CDS MMAR_4836 NC_010612.1 5892201 5895269 D thought to be involved in fatty acid transport; MmpL family transport protein 5892201..5895269 Mycobacterium marinum M 6229122 YP_001853097.1 CDS MMAR_4837 NC_010612.1 5895233 5896177 D function unknown; hydrolase 5895233..5896177 Mycobacterium marinum M 6229123 YP_001853098.1 CDS MMAR_4838 NC_010612.1 5896293 5896715 R hypothetical protein complement(5896293..5896715) Mycobacterium marinum M 6229124 YP_001853099.1 CDS MMAR_4839 NC_010612.1 5896761 5897393 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(5896761..5897393) Mycobacterium marinum M 6229125 YP_001853100.1 CDS MMAR_4840 NC_010612.1 5897637 5898377 D involved in transcriptional mechanism; putative regulatory protein 5897637..5898377 Mycobacterium marinum M 6229126 YP_001853101.1 CDS MMAR_4841 NC_010612.1 5898448 5898876 R may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair; hypothetical protein complement(5898448..5898876) Mycobacterium marinum M 6229127 YP_001853102.1 CDS MMAR_4842 NC_010612.1 5898954 5899748 D involved in unknown transcriptional regulatory network; regulatory protein 5898954..5899748 Mycobacterium marinum M 6229128 YP_001853103.1 CDS MMAR_4843 NC_010612.1 5899848 5900270 D hypothetical protein 5899848..5900270 Mycobacterium marinum M 6229129 YP_001853104.1 CDS MMAR_4845 NC_010612.1 5901219 5901500 D transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 5901219..5901500 Mycobacterium marinum M 6229131 YP_001853105.1 CDS MMAR_4846 NC_010612.1 5901542 5902336 D transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 5901542..5902336 Mycobacterium marinum M 6229132 YP_001853106.1 CDS MMAR_4847 NC_010612.1 5902868 5903098 D hypothetical protein 5902868..5903098 Mycobacterium marinum M 6229133 YP_001853107.1 CDS MMAR_4848 NC_010612.1 5903099 5904256 D part of a prophage not present in M. ulcerans. however a highly related integrase is present in M. ulcerans; prophage integrase 5903099..5904256 Mycobacterium marinum M 6229134 YP_001853108.1 CDS MMAR_4849 NC_010612.1 5904980 5905792 D hypothetical protein 5904980..5905792 Mycobacterium marinum M 6229139 YP_001853109.1 CDS MMAR_4850 NC_010612.1 5905810 5906715 R function unknown, may be involved in polyketide biosynthesis [secondary metabolites biosynthesis, transport, and catabolism]; O-methyltransferase complement(5905810..5906715) Mycobacterium marinum M 6229140 YP_001853110.1 CDS MMAR_4851 NC_010612.1 5906809 5907309 D domain homology to CumB, cytosine/adenosine deaminases; deaminase 5906809..5907309 Mycobacterium marinum M 6229141 YP_001853111.1 CDS MMAR_4852 NC_010612.1 5907367 5907738 D transcription regulator ArsR 5907367..5907738 Mycobacterium marinum M 6229142 YP_001853112.1 CDS MMAR_4853 NC_010612.1 5907795 5907998 D hypothetical protein 5907795..5907998 Mycobacterium marinum M 6229143 YP_001853113.1 CDS MMAR_4854 NC_010612.1 5908011 5909069 R hypothetical protein complement(5908011..5909069) Mycobacterium marinum M 6229144 YP_001853114.1 CDS MMAR_4855 NC_010612.1 5909143 5909784 D hypothetical protein 5909143..5909784 Mycobacterium marinum M 6229145 YP_001853115.1 CDS desA1 NC_010612.1 5909952 5910968 D involved in mycolic acid biosynthesis; acyl-[acyl-carrier protein] desaturase DesA1 5909952..5910968 Mycobacterium marinum M 6229146 YP_001853116.1 CDS MMAR_4857 NC_010612.1 5910977 5912110 D domain homology - tRNA-dihydrouridine synthase [translation, ribosomal structure and biogenesis]; transcriptional regulator 5910977..5912110 Mycobacterium marinum M 6229147 YP_001853117.1 CDS MMAR_4858 NC_010612.1 5912377 5914500 D domain conservation - LytR, transcriptional regulator; hypothetical protein 5912377..5914500 Mycobacterium marinum M 6229148 YP_001853118.1 CDS phoY2 NC_010612.1 5914558 5915226 D involved in transcriptional regulation of active transport of inorganic phosphate across the membrane; phosphate-transport system regulatory protein, PhoY2 5914558..5915226 Mycobacterium marinum M 6229149 YP_001853119.1 CDS phoT NC_010612.1 5915262 5916038 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(5915262..5916038) Mycobacterium marinum M 6229150 YP_001853120.1 CDS pstA NC_010612.1 5916058 5916966 R involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport; phosphate-transport integral membrane ABC transporter, PstA complement(5916058..5916966) Mycobacterium marinum M 6229151 YP_001853121.1 CDS pstC2_1 NC_010612.1 5916963 5917994 R involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport; phosphate-transport integral membrane ABC transporter PstC2 complement(5916963..5917994) Mycobacterium marinum M 6229152 YP_001853122.1 CDS phoS3 NC_010612.1 5918051 5919157 R involved in phosphate transport; phosphate-binding protein 3 , PhoS3 complement(5918051..5919157) Mycobacterium marinum M 6229153 YP_001853123.1 CDS mshD NC_010612.1 5919294 5920256 R involved in the fourth step of mycothiol biosynthesis; mycothiol acetyltransferase, MshD complement(5919294..5920256) Mycobacterium marinum M 6229154 YP_001853124.1 CDS MMAR_4865 NC_010612.1 5920253 5921047 R involved in transcriptional mechanism; transcriptional regulatory protein complement(5920253..5921047) Mycobacterium marinum M 6229155 YP_001853125.1 CDS MMAR_4866 NC_010612.1 5921424 5922236 D hypothetical protein 5921424..5922236 Mycobacterium marinum M 6229156 YP_001853126.1 CDS MMAR_4867 NC_010612.1 5922536 5923006 D integral membrane protein 5922536..5923006 Mycobacterium marinum M 6229157 YP_001853127.1 CDS cysA2 NC_010612.1 5923044 5923886 D may be a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]; thiosulfate sulfurtransferase, CysA2 5923044..5923886 Mycobacterium marinum M 6229158 YP_001853128.1 CDS sseC2 NC_010612.1 5923888 5924190 D sulfur metabolism protein, SseC2 5923888..5924190 Mycobacterium marinum M 6229159 YP_001853129.1 CDS MMAR_4870 NC_010612.1 5924247 5924345 D no H37Rv ortholog - very small, doubtful ORF; hypothetical protein 5924247..5924345 Mycobacterium marinum M 6229160 YP_001853130.1 CDS MMAR_4871 NC_010612.1 5924342 5925013 D N-terminal truncated in relation to orthologs; hypothetical protein 5924342..5925013 Mycobacterium marinum M 6229161 YP_001853131.1 CDS MMAR_4872 NC_010612.1 5925139 5927505 D contains a RyR domain. This domain is called RyR for Ryanodine receptor; hypothetical protein 5925139..5927505 Mycobacterium marinum M 6229162 YP_001853132.1 CDS pabC NC_010612.1 5927766 5928656 R catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase complement(5927766..5928656) Mycobacterium marinum M 6229163 YP_001853133.1 CDS MMAR_4874 NC_010612.1 5928791 5929144 D hypothetical protein 5928791..5929144 Mycobacterium marinum M 6229164 YP_001853134.1 CDS MMAR_4875 NC_010612.1 5929246 5929554 D hypothetical protein 5929246..5929554 Mycobacterium marinum M 6229165 YP_001853135.1 CDS ctpV NC_010612.1 5929541 5931943 D metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase, CtpV 5929541..5931943 Mycobacterium marinum M 6229166 YP_001853136.1 CDS MMAR_4877 NC_010612.1 5931980 5932555 D hypothetical protein 5931980..5932555 Mycobacterium marinum M 6229167 YP_001853137.1 CDS MMAR_4878 NC_010612.1 5932577 5933668 D contains predicted aminomethyltransferase domain, related to GcvT - involved in the catabolism of glycine; hypothetical protein 5932577..5933668 Mycobacterium marinum M 6229168 YP_001853138.1 CDS MMAR_4879 NC_010612.1 5933827 5934006 D hypothetical protein 5933827..5934006 Mycobacterium marinum M 6229169 YP_001853139.1 CDS purM NC_010612.1 5934100 5935203 R catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase complement(5934100..5935203) Mycobacterium marinum M 6229170 YP_001853140.1 CDS purF NC_010612.1 5935267 5936793 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(5935267..5936793) Mycobacterium marinum M 6229171 YP_001853141.1 CDS MMAR_4882 NC_010612.1 5936932 5937321 R hypothetical protein complement(5936932..5937321) Mycobacterium marinum M 6229172 YP_001853142.1 CDS mce2A NC_010612.1 5937341 5938546 D MCE-family protein Mce2A 5937341..5938546 Mycobacterium marinum M 6229173 YP_001853143.1 CDS MMAR_4884 NC_010612.1 5938586 5939857 D lipoprotein 5938586..5939857 Mycobacterium marinum M 6229174 YP_001853144.1 CDS cpsY NC_010612.1 5940080 5941678 D thought to be involved in exopolysaccharide and/or lipopolysaccharide biosynthetic pathway [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase 5940080..5941678 Mycobacterium marinum M 6229175 YP_001853145.1 CDS MMAR_4886 NC_010612.1 5941623 5942579 R contains phosphohydrolase domain; hypothetical protein complement(5941623..5942579) Mycobacterium marinum M 6229176 YP_001853146.1 CDS MMAR_4887 NC_010612.1 5942631 5943245 R contains CAAX amino terminal protease domain. members of this family are probably proteases; the family contains CAAX prenyl protease. the proteins contain a highly conserved Glu-Glu motif at the amino End of the alignment. the alignment also contains two histidine residues that may be involved in zinc binding; hypothetical protein complement(5942631..5943245) Mycobacterium marinum M 6229177 YP_001853147.1 CDS purL NC_010612.1 5943278 5945575 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II complement(5943278..5945575) Mycobacterium marinum M 6229178 YP_001853148.1 CDS MMAR_4889 NC_010612.1 5945673 5946323 D domain similarity with acetyltransferases; hypothetical protein 5945673..5946323 Mycobacterium marinum M 6229179 YP_001853149.1 CDS MMAR_4890 NC_010612.1 5946342 5946689 R hypothetical protein complement(5946342..5946689) Mycobacterium marinum M 6229180 YP_001853150.1 CDS pepC NC_010612.1 5946714 5948006 R catalyzes the removal of amino acids from the N termini of peptides; putative aminopeptidase 2 complement(5946714..5948006) Mycobacterium marinum M 6229181 YP_001853151.1 CDS MMAR_4892 NC_010612.1 5948059 5949066 D contains Dyp-type peroxidase domain. this family of dye-decolourising peroxidases lack a typical heme-binding region; hypothetical protein 5948059..5949066 Mycobacterium marinum M 6229182 YP_001853152.1 CDS cfp29 NC_010612.1 5949063 5949869 D function unknown, high domain homology to Linocin_M18, Linocin_M18 bacteriocin protein. the Linocin_M18 region is found mostly in eubacteria, though homologous sequences have been identified in archaea; 29 kDa antigen Cfp29 5949063..5949869 Mycobacterium marinum M 6229183 YP_001853153.1 CDS lpdB NC_010612.1 5950427 5951911 D contains pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component domain; dihydrolipoamide dehydrogenase, LpdB 5950427..5951911 Mycobacterium marinum M 6229184 YP_001853154.1 CDS MMAR_4895 NC_010612.1 5951937 5952401 D contains mannose-6-phosphate isomerase [carbohydrate transport and metabolism]; hypothetical protein 5951937..5952401 Mycobacterium marinum M 6229185 YP_001853155.1 CDS MMAR_4896 NC_010612.1 5952502 5952966 D hypothetical protein 5952502..5952966 Mycobacterium marinum M 6229186 YP_001853156.1 CDS purQ NC_010612.1 5952978 5953652 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I complement(5952978..5953652) Mycobacterium marinum M 6229187 YP_001853157.1 CDS MMAR_4898 NC_010612.1 5953649 5953894 R With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS complement(5953649..5953894) Mycobacterium marinum M 6229188 YP_001853158.1 CDS MMAR_4899 NC_010612.1 5954217 5955284 D PPE family protein 5954217..5955284 Mycobacterium marinum M 6229189 YP_001853159.1 CDS MMAR_4900 NC_010612.1 5955311 5956030 R hypothetical protein complement(5955311..5956030) Mycobacterium marinum M 6229190 YP_001853160.1 CDS MMAR_4901 NC_010612.1 5956016 5956654 D Zn-dependent hydrolase 5956016..5956654 Mycobacterium marinum M 6229191 YP_001853161.1 CDS MMAR_4902 NC_010612.1 5956734 5957648 R function unknown; belongs to the LysR family of transcriptional regulators; putative regulatory protein complement(5956734..5957648) Mycobacterium marinum M 6229192 YP_001853162.1 CDS MMAR_4903 NC_010612.1 5957772 5958779 D hypothetical protein 5957772..5958779 Mycobacterium marinum M 6229193 YP_001853163.1 CDS MMAR_4904 NC_010612.1 5958737 5959441 R hypothetical protein complement(5958737..5959441) Mycobacterium marinum M 6229194 YP_001853164.1 CDS MMAR_4905 NC_010612.1 5959610 5961229 D translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane drug efflux protein 5959610..5961229 Mycobacterium marinum M 6229195 YP_001853165.1 CDS MMAR_4906 NC_010612.1 5961219 5961782 R TetR-family; transcriptional regulator complement(5961219..5961782) Mycobacterium marinum M 6229196 YP_001853166.1 CDS MMAR_4907 NC_010612.1 5961877 5962326 D hypothetical protein 5961877..5962326 Mycobacterium marinum M 6229197 YP_001853167.1 CDS ptrB NC_010612.1 5962285 5964402 R cleaves peptide bonds on the C-terminal side of LysYL and argininyl residues [catalytic activity: hydrolysis of arg-|-xaa and lys-|-xaa bonds in oligopeptides, even when P1' residue is proline]; protease II (oligopeptidase B), PtrB complement(5962285..5964402) Mycobacterium marinum M 6229198 YP_001853168.1 CDS purC NC_010612.1 5964399 5965292 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(5964399..5965292) Mycobacterium marinum M 6229199 YP_001853169.1 CDS MMAR_4910 NC_010612.1 5965357 5965977 D transmembrane protein 5965357..5965977 Mycobacterium marinum M 6229200 YP_001853170.1 CDS adhX NC_010612.1 5965968 5967029 R Zn-dependent alcohol dehydrogenase, AdhX complement(5965968..5967029) Mycobacterium marinum M 6229201 YP_001853171.1 CDS MMAR_4912 NC_010612.1 5967081 5968604 R interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase complement(5967081..5968604) Mycobacterium marinum M 6229202 YP_001853172.1 CDS MMAR_4913 NC_010612.1 5968736 5970019 R possibly involed in transcription regulation; DNA- binding; putative regulatory protein complement(5968736..5970019) Mycobacterium marinum M 6229203 YP_001853173.1 CDS MMAR_4914 NC_010612.1 5970229 5971437 R PPE family protein complement(5970229..5971437) Mycobacterium marinum M 6229204 YP_001853174.1 CDS cyp126A3 NC_010612.1 5971724 5972980 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 126A3 Cyp126A3 complement(5971724..5972980) Mycobacterium marinum M 6229205 YP_001853175.1 CDS purB NC_010612.1 5972977 5974404 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(5972977..5974404) Mycobacterium marinum M 6229206 YP_001853176.1 CDS MMAR_4917 NC_010612.1 5974523 5975284 D hypothetical protein 5974523..5975284 Mycobacterium marinum M 6229207 YP_001853177.1 CDS MMAR_4918 NC_010612.1 5975281 5975904 R contains transcriptional regulatory domain; hypothetical protein complement(5975281..5975904) Mycobacterium marinum M 6229208 YP_001853178.1 CDS MMAR_4919 NC_010612.1 5975960 5976871 D function unknown, contains esterase domain; hypothetical protein 5975960..5976871 Mycobacterium marinum M 6229209 YP_001853179.1 CDS ggtA NC_010612.1 5976939 5978540 D besides the cephalosporin acylase I activity which converts GL-7ACA into 7-Aca; this enzyme displays some gamma glutamyltranspeptidase activity: Ggt plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. [catalytic activity 1: 7-beta-(4-carboxybutanamido)-cephalosporanic acid + H2O = 7-aminocephalosporanic acid + glutaric acid] [catalytic activity 2: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid]; bifunctional acylase, GgtA 5976939..5978540 Mycobacterium marinum M 6229210 YP_001853180.1 CDS moeY NC_010612.1 5978988 5981114 D involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD); hypothetical protein 5978988..5981114 Mycobacterium marinum M 6229211 YP_001853181.1 CDS MMAR_4922 NC_010612.1 5981143 5982057 R domain: UspA, universal stress protein UspA and related nucleotide-binding proteins [signal transduction mechanisms]; hypothetical protein complement(5981143..5982057) Mycobacterium marinum M 6229212 YP_001853182.1 CDS pknF_2 NC_010612.1 5982387 5983925 D involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase PknF_2 5982387..5983925 Mycobacterium marinum M 6229213 YP_001853183.1 CDS purD NC_010612.1 5983965 5985233 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(5983965..5985233) Mycobacterium marinum M 6229214 YP_001853184.1 CDS MMAR_4925 NC_010612.1 5985272 5985709 R involved in aromatic hydrocarbons catabolism. thought to be involved in the catabolism of protocatechuate to succinate-and acetyl-CoA in the beta- ketoadipate pathway (at the third step) [catalytic activity: 2-carboxy-5-OXO-2,5-dihydrofuran-2-acetate = 5- OXO-4,5-dihydrofuran-2-acetate + CO(2)]; 4-carboxymuconolactone decarboxylase complement(5985272..5985709) Mycobacterium marinum M 6229215 YP_001853185.1 CDS MMAR_4926 NC_010612.1 5985709 5986575 R dehydrogenase/reductase complement(5985709..5986575) Mycobacterium marinum M 6229216 YP_001853186.1 CDS MMAR_4927 NC_010612.1 5986622 5987374 R short chain dehydrogenase complement(5986622..5987374) Mycobacterium marinum M 6229217 YP_001853187.1 CDS aldA NC_010612.1 5987385 5988854 R oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD-dependent aldehyde dehydrogenase AldA complement(5987385..5988854) Mycobacterium marinum M 6229218 YP_001853188.1 CDS MMAR_4929 NC_010612.1 5989060 5989728 D hypothetical protein 5989060..5989728 Mycobacterium marinum M 6229219 YP_001853189.1 CDS cyp123A3 NC_010612.1 5989725 5990945 D cytochrome P450s are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 123A3 Cyp123A3 5989725..5990945 Mycobacterium marinum M 6229220 YP_001853190.1 CDS MMAR_4931 NC_010612.1 5990945 5991769 D function unknown, domain homology to short-chain dehydrogenase/reductase family; short chain dehydrogenase 5990945..5991769 Mycobacterium marinum M 6229221 YP_001853191.1 CDS cyp51B1 NC_010612.1 5991766 5993136 D involved in sterol biosynthesis. its biological substrate is not known. catalyzes C14-demethylation of lanosterol, 24,25-DIHYDROLANOSTEROL and obtusifoliol which is critical for ergosterol biosynthesis. it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3- beta-ol; cytochrome P450 51B1 Cyp51B1 5991766..5993136 Mycobacterium marinum M 6229222 YP_001853192.1 CDS MMAR_4933 NC_010612.1 5993136 5993342 D ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably involved in electron transport for cytochrome P- 450 system; ferredoxin 5993136..5993342 Mycobacterium marinum M 6229223 YP_001853193.1 CDS MMAR_4934 NC_010612.1 5993348 5993893 D hypothetical protein 5993348..5993893 Mycobacterium marinum M 6229224 YP_001853194.1 CDS adhB NC_010612.1 5994056 5995183 D thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD- dependent AdhB 5994056..5995183 Mycobacterium marinum M 6229225 YP_001853195.1 CDS MMAR_4936 NC_010612.1 5995213 5995497 D function unknown, domain homology suggests possible NADH:flavin oxidoreductase; hypothetical protein 5995213..5995497 Mycobacterium marinum M 6229226 YP_001853196.1 CDS MMAR_4937 NC_010612.1 5995500 5995919 D contains nuclear transport factor 2 (NTF2) domain; hypothetical protein 5995500..5995919 Mycobacterium marinum M 6229227 YP_001853197.1 CDS MMAR_4938 NC_010612.1 5995921 5997363 R hypothetical protein complement(5995921..5997363) Mycobacterium marinum M 6229228 YP_001853198.1 CDS MMAR_4939 NC_010612.1 5997792 5999183 D PE-PGRS family protein 5997792..5999183 Mycobacterium marinum M 6229229 YP_001853199.1 CDS MMAR_4940 NC_010612.1 5999188 5999592 D hit family protein: diadenosine tetraphosphate (Ap4A) hydrolase and other hit family hydrolases [nucleotide transport and metabolism / carbohydrate transport and metabolism / general function prediction only]; hypothetical protein 5999188..5999592 Mycobacterium marinum M 6229230 YP_001853200.1 CDS phoR NC_010612.1 5999599 6001044 R sensor part of a two-component regulatory system. this protein is thought to be a sensor kinase for the phosphate regulon. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited; two-component system response phosphate sensor kinase, PhoR complement(5999599..6001044) Mycobacterium marinum M 6229231 YP_001853201.1 CDS phoP NC_010612.1 6001085 6001807 R involved in transcriptional mechanism. part of the two-component regulatory system PhoP/PhoQ. this protein is thought to be a positive regulator for the phosphate regulon, required for intracellular growth. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited; two-component system response phosphate regulon transcriptional regulator, PhoP complement(6001085..6001807) Mycobacterium marinum M 6229232 YP_001853202.1 CDS MMAR_4943 NC_010612.1 6001969 6002697 D hypothetical protein 6001969..6002697 Mycobacterium marinum M 6229233 YP_001853203.1 CDS MMAR_4944 NC_010612.1 6003001 6004167 D domain: UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [coenzyme metabolism / energy production and conversion]; oxidoreductase 6003001..6004167 Mycobacterium marinum M 6229235 YP_001853204.1 CDS MMAR_4945 NC_010612.1 6004151 6006853 R carbon monoxide dehydrogenase complement(6004151..6006853) Mycobacterium marinum M 6229236 YP_001853205.1 CDS MMAR_4946 NC_010612.1 6006850 6007674 R domain: xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit a [nucleotide transport and metabolism]; hypothetical protein complement(6006850..6007674) Mycobacterium marinum M 6229237 YP_001853206.1 CDS MMAR_4947 NC_010612.1 6007674 6007994 R domain homology: transthyretin, transthyretin precursor (formerly prealbumin). transthyretin is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. mutations in the human transthyretin are associated with several genetic disorders; hypothetical protein complement(6007674..6007994) Mycobacterium marinum M 6229238 YP_001853207.1 CDS MMAR_4948 NC_010612.1 6008032 6008535 R putative OHCU decarboxylase complement(6008032..6008535) Mycobacterium marinum M 6229239 YP_001853208.1 CDS MMAR_4949 NC_010612.1 6008536 6010437 R permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices; xanthine/uracil permease complement(6008536..6010437) Mycobacterium marinum M 6229240 YP_001853209.1 CDS atsD NC_010612.1 6010518 6012929 R thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase AtsD complement(6010518..6012929) Mycobacterium marinum M 6229241 YP_001853210.1 CDS MMAR_4951 NC_010612.1 6013166 6014380 D domain: regulator of polyketide synthase expression; hypothetical protein 6013166..6014380 Mycobacterium marinum M 6229242 YP_001853211.1 CDS echA8_3 NC_010612.1 6014391 6015197 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(6014391..6015197) Mycobacterium marinum M 6229243 YP_001853212.1 CDS MMAR_4953 NC_010612.1 6015223 6016956 R PE-PGRS family protein complement(6015223..6016956) Mycobacterium marinum M 6229244 YP_001853213.1 CDS amiC_2 NC_010612.1 6017199 6018692 D hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidase 6017199..6018692 Mycobacterium marinum M 6229245 YP_001853214.1 CDS MMAR_4955 NC_010612.1 6018713 6020203 R hypothetical protein complement(6018713..6020203) Mycobacterium marinum M 6229246 YP_001853215.1 CDS MMAR_4956 NC_010612.1 6020414 6022051 D function unknown; facilitates transport of small solutes in or out of the cell; multidrug resistance integral membrane efflux protein 6020414..6022051 Mycobacterium marinum M 6229247 YP_001853216.1 CDS MMAR_4957 NC_010612.1 6022093 6022575 R hypothetical protein complement(6022093..6022575) Mycobacterium marinum M 6229248 YP_001853217.1 CDS MMAR_4958 NC_010612.1 6022708 6023094 D hypothetical protein 6022708..6023094 Mycobacterium marinum M 6229249 YP_001853218.1 CDS MMAR_4959 NC_010612.1 6023215 6023478 D hypothetical protein 6023215..6023478 Mycobacterium marinum M 6229250 YP_001853219.1 CDS bpoA NC_010612.1 6023547 6024422 R supposed involved in detoxification reactions; peroxidase BpoA complement(6023547..6024422) Mycobacterium marinum M 6229251 YP_001853220.1 CDS MMAR_4961 NC_010612.1 6024527 6025216 R hypothetical protein complement(6024527..6025216) Mycobacterium marinum M 6229252 YP_001853221.1 CDS MMAR_4962 NC_010612.1 6025299 6026450 R possibly involved in the uptake of malate and other dicarboxylates by a proton symport mechanism. in E. coli, this protein has been implicated in resistance to tellurite; C4-dicarboxylate transporter/malic acid transport protein complement(6025299..6026450) Mycobacterium marinum M 6229253 YP_001853222.1 CDS MMAR_4963 NC_010612.1 6026654 6026896 D hypothetical protein 6026654..6026896 Mycobacterium marinum M 6229254 YP_001853223.1 CDS MMAR_4964 NC_010612.1 6026952 6027695 R hypothetical protein complement(6026952..6027695) Mycobacterium marinum M 6229255 YP_001853224.1 CDS MMAR_4965 NC_010612.1 6027764 6028468 R hypothetical protein complement(6027764..6028468) Mycobacterium marinum M 6229256 YP_001853225.1 CDS cpsA NC_010612.1 6028733 6030268 D function unknown but contains a cell envelope- related transcriptional attenuator domain. CpsA is a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane- bound proteins. may play a role in regulation of transcription; membrane protein CpsA 6028733..6030268 Mycobacterium marinum M 6229257 YP_001853226.1 CDS MMAR_4967 NC_010612.1 6030275 6031066 R function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase complement(6030275..6031066) Mycobacterium marinum M 6229258 YP_001853227.1 CDS MMAR_4968 NC_010612.1 6031070 6031903 R function unknown, supposed to be involved in cellular metabolism; short chain dehydrogenase complement(6031070..6031903) Mycobacterium marinum M 6229259 YP_001853228.1 CDS MMAR_4969 NC_010612.1 6031995 6032237 R probable role in the biosynthesis of the product from U/S PKS gene, carrying its acyl intermediates; acyl carrier protein complement(6031995..6032237) Mycobacterium marinum M 6229260 YP_001853229.1 CDS MMAR_4970 NC_010612.1 6032234 6033883 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(6032234..6033883) Mycobacterium marinum M 6229261 YP_001853230.1 CDS bioF2 NC_010612.1 6034024 6035268 R could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase complement(6034024..6035268) Mycobacterium marinum M 6229262 YP_001853231.1 CDS echA13_1 NC_010612.1 6035459 6036394 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(6035459..6036394) Mycobacterium marinum M 6229263 YP_001853232.1 CDS MMAR_4973 NC_010612.1 6036461 6037294 R function unknown but domain identity suggests permease component of an uncharacterized ABC-type transport system; hypothetical protein complement(6036461..6037294) Mycobacterium marinum M 6229264 YP_001853233.1 CDS pstB NC_010612.1 6037294 6037974 R involved in active transport of inorganic phosphate across the membrane (import); responsible for energy coupling to the transport system. this is one of the proteins required for binding-protein-mediated phosphate transport. have ATP-binding ability and ATPase activity; phosphate-transport ATP-binding protein ABC transporter PstB complement(6037294..6037974) Mycobacterium marinum M 6229265 YP_001853234.1 CDS MMAR_4975 NC_010612.1 6038674 6041613 D function unknown. belongs to the predicted drug exporters of the rnd superfamily; MmpL family transport protein 6038674..6041613 Mycobacterium marinum M 6229266 YP_001853235.1 CDS MMAR_4976 NC_010612.1 6041704 6042006 D members of the PadR-like family are transcriptional regulators that appear to be related to the pfam01047 family. this family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism; hypothetical protein 6041704..6042006 Mycobacterium marinum M 6229267 YP_001853236.1 CDS MMAR_4977 NC_010612.1 6042074 6042238 D hypothetical protein 6042074..6042238 Mycobacterium marinum M 6229268 YP_001853237.1 CDS otsA NC_010612.1 6042239 6043741 D involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]; alpha, alpha-trehalose-phosphate synthase OtsA 6042239..6043741 Mycobacterium marinum M 6229269 YP_001853238.1 CDS MMAR_4979 NC_010612.1 6043829 6044410 D hypothetical protein 6043829..6044410 Mycobacterium marinum M 6229270 YP_001853239.1 CDS MMAR_4980 NC_010612.1 6044455 6044955 R MCE-associated protein complement(6044455..6044955) Mycobacterium marinum M 6229271 YP_001853240.1 CDS MMAR_4981 NC_010612.1 6044955 6045686 R hypothetical protein complement(6044955..6045686) Mycobacterium marinum M 6229272 YP_001853241.1 CDS mce4F NC_010612.1 6045719 6047401 R function unknown, but thought involved in host cell invasion; MCE-family protein Mce4F complement(6045719..6047401) Mycobacterium marinum M 6229273 YP_001853242.1 CDS lprN NC_010612.1 6047413 6048564 R function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein LprN complement(6047413..6048564) Mycobacterium marinum M 6229274 YP_001853243.1 CDS mce4D NC_010612.1 6048561 6049994 R function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce4D complement(6048561..6049994) Mycobacterium marinum M 6229275 YP_001853244.1 CDS mce4C NC_010612.1 6049991 6051052 R function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce4C complement(6049991..6051052) Mycobacterium marinum M 6229276 YP_001853245.1 CDS mce4B NC_010612.1 6051042 6052094 R function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce4B complement(6051042..6052094) Mycobacterium marinum M 6229277 YP_001853246.1 CDS mce4A NC_010612.1 6052094 6053296 R function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce4A complement(6052094..6053296) Mycobacterium marinum M 6229278 YP_001853247.1 CDS yrbE4B NC_010612.1 6053312 6054154 R membrane protein YrbE4B complement(6053312..6054154) Mycobacterium marinum M 6229279 YP_001853248.1 CDS yrbE4A NC_010612.1 6054189 6054902 R membrane protein YrbE4A complement(6054189..6054902) Mycobacterium marinum M 6229280 YP_001853249.1 CDS fabG NC_010612.1 6055190 6056101 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(6055190..6056101) Mycobacterium marinum M 6229281 YP_001853250.1 CDS fdxD NC_010612.1 6056172 6056420 R ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxD complement(6056172..6056420) Mycobacterium marinum M 6229282 YP_001853251.1 CDS fadE26 NC_010612.1 6056588 6057766 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE26 6056588..6057766 Mycobacterium marinum M 6229283 YP_001853252.1 CDS fadE27 NC_010612.1 6057797 6058894 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE27 6057797..6058894 Mycobacterium marinum M 6229284 YP_001853253.1 CDS fadD17 NC_010612.1 6058957 6060468 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 6058957..6060468 Mycobacterium marinum M 6229285 YP_001853254.1 CDS MMAR_4995 NC_010612.1 6060576 6064802 D PE-PGRS family protein 6060576..6064802 Mycobacterium marinum M 6229286 YP_001853255.1 CDS MMAR_4996 NC_010612.1 6064805 6065527 D function unknown but contains beta- lactamase/transpeptidase-like superfamily domain; hypothetical protein 6064805..6065527 Mycobacterium marinum M 6229287 YP_001853256.1 CDS ilvX NC_010612.1 6065524 6067071 R thiamine-pyrophosphate requiring enzyme; hypothetical protein complement(6065524..6067071) Mycobacterium marinum M 6229288 YP_001853257.1 CDS MMAR_4998 NC_010612.1 6067084 6067914 R function unknown. these proteins are related to the metal-dependent hydrolase superfamily; hypothetical protein complement(6067084..6067914) Mycobacterium marinum M 6229289 YP_001853258.1 CDS MMAR_4999 NC_010612.1 6068164 6072894 D PE-PGRS family protein 6068164..6072894 Mycobacterium marinum M 6229290 YP_001853259.1 CDS MMAR_5000 NC_010612.1 6073476 6074243 R fructosamine kinase-like protein complement(6073476..6074243) Mycobacterium marinum M 6229291 YP_001853260.1 CDS fadD19_1 NC_010612.1 6074257 6075909 R activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase complement(6074257..6075909) Mycobacterium marinum M 6229292 YP_001853261.1 CDS echA19 NC_010612.1 6075974 6076798 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 6075974..6076798 Mycobacterium marinum M 6229293 YP_001853262.1 CDS cyp142A3 NC_010612.1 6076816 6078021 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 142A3 Cyp142A3 complement(6076816..6078021) Mycobacterium marinum M 6229294 YP_001853263.1 CDS MMAR_5004 NC_010612.1 6078051 6078761 D hypothetical protein 6078051..6078761 Mycobacterium marinum M 6229295 YP_001853264.1 CDS MMAR_5005 NC_010612.1 6078822 6079859 R function unknown, probably involved in cellular metabolism; coenzyme F420-dependent oxidoreductase complement(6078822..6079859) Mycobacterium marinum M 6229296 YP_001853265.1 CDS MMAR_5006 NC_010612.1 6079930 6080919 D function unknown, contains a C-term predicted nucleic-acid-binding domain; hypothetical protein 6079930..6080919 Mycobacterium marinum M 6229297 YP_001853266.1 CDS ltp4 NC_010612.1 6080935 6081996 D function unknown, probably involved in lipid metabolism; lipid-transfer protein 6080935..6081996 Mycobacterium marinum M 6229298 YP_001853267.1 CDS ltp3 NC_010612.1 6081996 6083174 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 6081996..6083174 Mycobacterium marinum M 6229299 YP_001853268.1 CDS MMAR_5009 NC_010612.1 6083171 6084061 D function unknown, probably involved in cellular metabolism; oxidoreductase 6083171..6084061 Mycobacterium marinum M 6229300 YP_001853269.1 CDS MMAR_5010 NC_010612.1 6084058 6084468 D function unknown, this class of proteins is involved in enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; ketosteroid isomerase- like protein 6084058..6084468 Mycobacterium marinum M 6229301 YP_001853270.1 CDS MMAR_5011 NC_010612.1 6084569 6085513 D hypothetical protein 6084569..6085513 Mycobacterium marinum M 6229302 YP_001853271.1 CDS MMAR_5012 NC_010612.1 6085720 6086658 D hypothetical protein 6085720..6086658 Mycobacterium marinum M 6229303 YP_001853272.1 CDS MMAR_5013 NC_010612.1 6086762 6088396 D function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein 6086762..6088396 Mycobacterium marinum M 6229304 YP_001853273.1 CDS MMAR_5014 NC_010612.1 6088403 6088927 R function unknown, contains carbonic anhydrases/acetyltransferase superfamily domain; hypothetical protein complement(6088403..6088927) Mycobacterium marinum M 6229305 YP_001853274.1 CDS MMAR_5015 NC_010612.1 6089041 6090225 D function unknown, probably involved in cellular metabolism; oxidoreductase 6089041..6090225 Mycobacterium marinum M 6229306 YP_001853275.1 CDS MMAR_5016 NC_010612.1 6090231 6090680 D hypothetical protein 6090231..6090680 Mycobacterium marinum M 6229307 YP_001853276.1 CDS MMAR_5017 NC_010612.1 6090684 6091829 R function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain; hypothetical protein complement(6090684..6091829) Mycobacterium marinum M 6229308 YP_001853277.1 CDS MMAR_5018 NC_010612.1 6091829 6092611 R function unknown, probably involved in cellular metabolism; short chain dehydrogenase complement(6091829..6092611) Mycobacterium marinum M 6229309 YP_001853278.1 CDS MMAR_5019 NC_010612.1 6092625 6093758 R hypothetical protein complement(6092625..6093758) Mycobacterium marinum M 6229310 YP_001853279.1 CDS gcs2 NC_010612.1 6093996 6096605 D function unknown, this enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis; glutamate--cysteine ligase, Gcs2 6093996..6096605 Mycobacterium marinum M 6229311 YP_001853280.1 CDS MMAR_5021 NC_010612.1 6096592 6097635 R catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase complement(6096592..6097635) Mycobacterium marinum M 6229312 YP_001853281.1 CDS mhpF_1 NC_010612.1 6097632 6098558 R catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase complement(6097632..6098558) Mycobacterium marinum M 6229313 YP_001853282.1 CDS MMAR_5023 NC_010612.1 6098602 6099387 R function unknown; probably involved in cellular metabolism; 2-keto-4-pentenoate hydratase complement(6098602..6099387) Mycobacterium marinum M 6229314 YP_001853283.1 CDS MMAR_5024 NC_010612.1 6099462 6101165 D initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 6099462..6101165 Mycobacterium marinum M 6229315 YP_001853284.1 CDS MMAR_5025 NC_010612.1 6101167 6102036 D function unknown, probably involved in cellular metabolism; dehydratase 6101167..6102036 Mycobacterium marinum M 6229316 YP_001853285.1 CDS MMAR_5026 NC_010612.1 6102124 6102969 R function unknown, contains restriction endonuclease- like superfamily domain; hypothetical protein complement(6102124..6102969) Mycobacterium marinum M 6229317 YP_001853286.1 CDS ltp2_1 NC_010612.1 6103100 6104260 R function unknown, supposed involvement in lipid metabolism; lipid-transfer protein complement(6103100..6104260) Mycobacterium marinum M 6229318 YP_001853287.1 CDS MMAR_5028 NC_010612.1 6104260 6104661 R function unknown, potential role in lipid metabolism. contains thioesterase/thiol ester dehydrase- isomerase superfamily domain; hypothetical protein complement(6104260..6104661) Mycobacterium marinum M 6229319 YP_001853288.1 CDS MMAR_5029 NC_010612.1 6104658 6105608 R function unknown, contains a predicted C-term nucleic-acid-binding protein; hypothetical protein complement(6104658..6105608) Mycobacterium marinum M 6229320 YP_001853289.1 CDS fadE29 NC_010612.1 6105605 6106768 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE29 complement(6105605..6106768) Mycobacterium marinum M 6229321 YP_001853290.1 CDS fadE28 NC_010612.1 6106753 6107784 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE28 complement(6106753..6107784) Mycobacterium marinum M 6229322 YP_001853291.1 CDS cyp125A7 NC_010612.1 6107802 6109055 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 125A7 Cyp125A7 complement(6107802..6109055) Mycobacterium marinum M 6229323 YP_001853292.1 CDS fadA5 NC_010612.1 6109226 6110401 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 6109226..6110401 Mycobacterium marinum M 6229324 YP_001853293.1 CDS MMAR_5034 NC_010612.1 6110409 6110795 D hypothetical protein 6110409..6110795 Mycobacterium marinum M 6229325 YP_001853294.1 CDS MMAR_5035 NC_010612.1 6110859 6111314 D function unknown; contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential; hypothetical protein 6110859..6111314 Mycobacterium marinum M 6229326 YP_001853295.1 CDS MMAR_5036 NC_010612.1 6111360 6112265 R function unknown, supposed involvement in cellular metabolism; short chain dehydrogenase complement(6111360..6112265) Mycobacterium marinum M 6229327 YP_001853296.1 CDS MMAR_5037 NC_010612.1 6112286 6113065 R function unknown, supposed involvement in cellular metabolism; short chain dehydrogenase complement(6112286..6113065) Mycobacterium marinum M 6229328 YP_001853297.1 CDS MMAR_5038 NC_010612.1 6113155 6115056 R PE-PGRS family protein complement(6113155..6115056) Mycobacterium marinum M 6229329 YP_001853298.1 CDS echA20 NC_010612.1 6115378 6116121 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 6115378..6116121 Mycobacterium marinum M 6229330 YP_001853299.1 CDS MMAR_5040 NC_010612.1 6116118 6116996 D function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another; CoA-transferase subunit alpha 6116118..6116996 Mycobacterium marinum M 6229331 YP_001853300.1 CDS MMAR_5041 NC_010612.1 6116993 6117736 D function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another; CoA-transferase subunit beta 6116993..6117736 Mycobacterium marinum M 6229332 YP_001853301.1 CDS MMAR_5042 NC_010612.1 6117733 6118800 D function unknown, members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor; 2-nitropropane dioxygenase 6117733..6118800 Mycobacterium marinum M 6229333 YP_001853302.1 CDS fdxB NC_010612.1 6118831 6120852 D function unknown, c-terminus probably involved in electron transfer in one or several metabolic reactions; electron transfer protein FdxB 6118831..6120852 Mycobacterium marinum M 6229334 YP_001853303.1 CDS MMAR_5044 NC_010612.1 6120939 6125294 R PE-PGRS family protein complement(6120939..6125294) Mycobacterium marinum M 6229335 YP_001853304.1 CDS fadA6_1 NC_010612.1 6125498 6126658 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(6125498..6126658) Mycobacterium marinum M 6229336 YP_001853305.1 CDS MMAR_5046 NC_010612.1 6126661 6127263 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(6126661..6127263) Mycobacterium marinum M 6229337 YP_001853306.1 CDS MMAR_5047 NC_010612.1 6127439 6129052 D PPE family protein 6127439..6129052 Mycobacterium marinum M 6229338 YP_001853307.1 CDS MMAR_5048 NC_010612.1 6129127 6129915 R function unknown, probably involved in cellular metabolism; short chain dehydrogenase complement(6129127..6129915) Mycobacterium marinum M 6229339 YP_001853308.1 CDS fadE30 NC_010612.1 6129912 6131060 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE30 complement(6129912..6131060) Mycobacterium marinum M 6229340 YP_001853309.1 CDS fadD3 NC_010612.1 6131131 6132654 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 6131131..6132654 Mycobacterium marinum M 6229341 YP_001853310.1 CDS fadE31 NC_010612.1 6132655 6133788 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE31 6132655..6133788 Mycobacterium marinum M 6229342 YP_001853311.1 CDS fadE32 NC_010612.1 6133792 6134727 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE32 6133792..6134727 Mycobacterium marinum M 6229343 YP_001853312.1 CDS fadE33 NC_010612.1 6134777 6135739 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE33 6134777..6135739 Mycobacterium marinum M 6229344 YP_001853313.1 CDS aspB NC_010612.1 6135736 6136911 D catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 6135736..6136911 Mycobacterium marinum M 6229345 YP_001853314.1 CDS nat NC_010612.1 6136925 6137767 R could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [catalytic activity: acetyl-CoA + arylamine = CoA + N- acetylarylamine]; arylamine N-acetyltransferase Nat complement(6136925..6137767) Mycobacterium marinum M 6229346 YP_001853315.1 CDS MMAR_5056 NC_010612.1 6137920 6138531 D function unknown; hypothetical protein 6137920..6138531 Mycobacterium marinum M 6229347 YP_001853316.1 CDS dsbF NC_010612.1 6138831 6139376 D function unknown, possibly involved in thiol:disulfide interchange. contains PS00013 prokaryotic membrane lipoprotein lipid attachment site, N-term signal pepitde sequence and PS00194 thioredoxin family active site; lipoprotein DsbF 6138831..6139376 Mycobacterium marinum M 6229348 YP_001853317.1 CDS MMAR_5058 NC_010612.1 6139373 6140260 D hypothetical protein 6139373..6140260 Mycobacterium marinum M 6229349 YP_001853318.1 CDS MMAR_5059 NC_010612.1 6140255 6141187 R function unknown, but domain identity suggests this protein may have metalloendopeptidase activity; peptidase M48 like- protein complement(6140255..6141187) Mycobacterium marinum M 6229350 YP_001853319.1 CDS MMAR_5060 NC_010612.1 6141184 6141522 R involved in transcriptional mechanism; transcriptional regulatory protein complement(6141184..6141522) Mycobacterium marinum M 6229351 YP_001853320.1 CDS MMAR_5061 NC_010612.1 6141711 6142118 D hypothetical protein 6141711..6142118 Mycobacterium marinum M 6229352 YP_001853321.1 CDS MMAR_5062 NC_010612.1 6142204 6142770 R function unknown, probably involved in cellular metabolism; oxidase complement(6142204..6142770) Mycobacterium marinum M 6229353 YP_001853322.1 CDS bphC NC_010612.1 6142782 6143684 R involved in the degradation of biphenyl [catalytic activity: biphenyl-2,3-diol + O(2) = 2-hydroxy-6-OXO-6- phenylhexa-2,4-dienoate + H(2)O]; biphenyl-2,3-diol 1,2-dioxygenase complement(6142782..6143684) Mycobacterium marinum M 6229354 YP_001853323.1 CDS bphD NC_010612.1 6143681 6144568 R involved in the degradation of biphenyl; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD complement(6143681..6144568) Mycobacterium marinum M 6229355 YP_001853324.1 CDS MMAR_5065 NC_010612.1 6144568 6145752 R function unknown, probably involved in cellular metabolism; acyl-CoA dehydrogenase complement(6144568..6145752) Mycobacterium marinum M 6229356 YP_001853325.1 CDS hmp NC_010612.1 6145946 6147022 D may play a role in protection from oxidative (nitric oxide) and nitrosative stress. may also be involved in anaerobic metabolism. could have nitric oxide dioxygenase activity; flavodoxin reductase Hmp 6145946..6147022 Mycobacterium marinum M 6229357 YP_001853326.1 CDS MMAR_5067 NC_010612.1 6147068 6147598 D hypothetical protein 6147068..6147598 Mycobacterium marinum M 6229358 YP_001853327.1 CDS fadE34 NC_010612.1 6147614 6149749 R function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE34 complement(6147614..6149749) Mycobacterium marinum M 6229359 YP_001853328.1 CDS MMAR_5069 NC_010612.1 6150031 6150633 D involved in transcriptional mechanism; TetR family transcriptional regulator 6150031..6150633 Mycobacterium marinum M 6229360 YP_001853329.1 CDS MMAR_5070 NC_010612.1 6150640 6151719 R involved in transcriptional mechanism; PurR family transcriptional regulator complement(6150640..6151719) Mycobacterium marinum M 6229361 YP_001853330.1 CDS MMAR_5071 NC_010612.1 6151812 6152720 D function unknown, domain identity suggests periplasmic solute binding protein, containing an ATP- binding cassette transport system; hypothetical protein 6151812..6152720 Mycobacterium marinum M 6229362 YP_001853331.1 CDS MMAR_5072 NC_010612.1 6152729 6153547 D function unknown, part of a binding-protein- dependent ABC transport system; ATPase component of an ABC-type transport system 6152729..6153547 Mycobacterium marinum M 6229363 YP_001853332.1 CDS MMAR_5073 NC_010612.1 6153544 6154395 D part of an ABC transport system; permease of an ABC-type transporter 6153544..6154395 Mycobacterium marinum M 6229364 YP_001853333.1 CDS lppH NC_010612.1 6154482 6155198 D lipoprotein LppH 6154482..6155198 Mycobacterium marinum M 6229365 YP_001853334.1 CDS MMAR_5075 NC_010612.1 6155213 6155962 D lipoprotein 6155213..6155962 Mycobacterium marinum M 6229366 YP_001853335.1 CDS lamB NC_010612.1 6155981 6156739 D function unknown, the lam locus of aspergillus nidulans consists of two divergently transcribed genes, lama and LamB, involved in the utilization of lactams such as 2-pyrrolidinone. both genes are under the control of the positive regulatory gene AmdR and are subject to carbon and nitrogen metabolite repression. the exact molecular function of the proteins in this family is unknown; LamB/YcsF family protein 6155981..6156739 Mycobacterium marinum M 6229367 YP_001853336.1 CDS MMAR_5077 NC_010612.1 6156739 6157659 D hypothetical protein 6156739..6157659 Mycobacterium marinum M 6229368 YP_001853337.1 CDS arsB2 NC_010612.1 6157682 6158923 D thought to be involved in transport of arsenic across the membrane (export): arsenic resistance by an export mechanism. form the channel of an arsenite pump responsible for the translocation of the substrate across the membrane; arsenical pump integral membrane protein ArsB2 6157682..6158923 Mycobacterium marinum M 6229369 YP_001853338.1 CDS MMAR_5079 NC_010612.1 6158946 6159878 R function unknown role in tRNA and rRNA base modification by methylation; tRNA/rRNA methyltransferase complement(6158946..6159878) Mycobacterium marinum M 6229370 YP_001853339.1 CDS cysS NC_010612.1 6159879 6161285 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(6159879..6161285) Mycobacterium marinum M 6229371 YP_001853340.1 CDS ispF NC_010612.1 6161343 6161840 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(6161343..6161840) Mycobacterium marinum M 6229372 YP_001853341.1 CDS ispD NC_010612.1 6161837 6162520 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(6161837..6162520) Mycobacterium marinum M 6229373 YP_001853342.1 CDS MMAR_5083 NC_010612.1 6162537 6163025 R function unknown role in regulation; transcriptional regulatory protein complement(6162537..6163025) Mycobacterium marinum M 6229374 YP_001853343.1 CDS lpqE NC_010612.1 6163468 6164025 D lipoprotein LpqE 6163468..6164025 Mycobacterium marinum M 6229375 YP_001853344.1 CDS radA NC_010612.1 6164067 6165542 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 6164067..6165542 Mycobacterium marinum M 6229376 YP_001853345.1 CDS MMAR_5086 NC_010612.1 6165561 6166637 D non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA 6165561..6166637 Mycobacterium marinum M 6229377 YP_001853346.1 CDS MMAR_5087 NC_010612.1 6166649 6167470 R hypothetical protein complement(6166649..6167470) Mycobacterium marinum M 6229378 YP_001853347.1 CDS MMAR_5088 NC_010612.1 6167560 6168186 R catalyzes the reversible hydratation of carbon dioxide [catalytic activity: H(2)CO(3) = CO(2) + H(2)O]; carbonic anhydrase complement(6167560..6168186) Mycobacterium marinum M 6229379 YP_001853348.1 CDS mutY NC_010612.1 6168203 6169087 D involved in base excision repair. removes adenine mispaired with 8-OXOG. may repair a.G and a.C mismatches by adenine excision; adenine glycosylase MutY 6168203..6169087 Mycobacterium marinum M 6229380 YP_001853349.1 CDS MMAR_5090 NC_010612.1 6169095 6169862 R function unknown, probably involved in cellular metabolism; hydrolase complement(6169095..6169862) Mycobacterium marinum M 6229381 YP_001853350.1 CDS MMAR_5091 NC_010612.1 6169918 6170235 D TB11.2; hypothetical protein 6169918..6170235 Mycobacterium marinum M 6229382 YP_001853351.1 CDS lpqF NC_010612.1 6170210 6171580 D lipoprotein LpqF 6170210..6171580 Mycobacterium marinum M 6229383 YP_001853352.1 CDS ppm1_2 NC_010612.1 6171438 6172400 R transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates; polyprenol-monophosphomannose synthase Ppm1_2 complement(6171438..6172400) Mycobacterium marinum M 6229384 YP_001853353.1 CDS MMAR_5094 NC_010612.1 6172397 6174019 R thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane; integral membrane transport protein complement(6172397..6174019) Mycobacterium marinum M 6229385 YP_001853354.1 CDS idsA1 NC_010612.1 6174030 6175070 R involved in the biosynthesis of membrane ether- linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [catalytic activity1: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate] [catalytic activity2: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans- farnesyl diphosphate] [catalytic activity3: trans-trans- farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate]; multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 complement(6174030..6175070) Mycobacterium marinum M 6229386 YP_001853355.1 CDS gpmB NC_010612.1 6175296 6175829 R may be involved in the catalysis of both the synthesis and the degradation of fructose-2,6- bisphosphate. beta-D-fructose 2,6-bisphosphate + H(2)O <=> D-fructose 6-phosphate + phosphate; fructose-2,6-bisphosphatase GpmB complement(6175296..6175829) Mycobacterium marinum M 6229387 YP_001853356.1 CDS MMAR_5097 NC_010612.1 6175837 6176628 R hypothetical protein complement(6175837..6176628) Mycobacterium marinum M 6229388 YP_001853357.1 CDS MMAR_5098 NC_010612.1 6176619 6176828 R hypothetical protein complement(6176619..6176828) Mycobacterium marinum M 6229389 YP_001853358.1 CDS MMAR_5099 NC_010612.1 6177005 6178375 R PE-PGRS family protein complement(6177005..6178375) Mycobacterium marinum M 6229390 YP_001853359.1 CDS clpC1 NC_010612.1 6178578 6181124 R hydrolyses proteins in presence of ATP. may interact with a ClpP-like protease involved in degradation of denatured proteins; ATP-dependent protease ATP-binding subunit ClpC1 complement(6178578..6181124) Mycobacterium marinum M 6229391 YP_001853360.1 CDS lsr2 NC_010612.1 6181502 6181843 R dominant T-cell antigen and may stimulate lymphocyte proliferation; iron-regulated Lsr2 protein complement(6181502..6181843) Mycobacterium marinum M 6229392 YP_001853361.1 CDS lysS NC_010612.1 6181958 6183454 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(6181958..6183454) Mycobacterium marinum M 6229393 YP_001853362.1 CDS MMAR_5103 NC_010612.1 6183576 6184394 R type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase complement(6183576..6184394) Mycobacterium marinum M 6229394 YP_001853363.1 CDS panD NC_010612.1 6184397 6184828 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(6184397..6184828) Mycobacterium marinum M 6229395 YP_001853364.1 CDS panC NC_010612.1 6184828 6185775 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(6184828..6185775) Mycobacterium marinum M 6229396 YP_001853365.1 CDS MMAR_5106 NC_010612.1 6185772 6186698 R function unknown contains NAD(P)-binding Rossmann- fold superfamily domains; hypothetical protein complement(6185772..6186698) Mycobacterium marinum M 6229397 YP_001853366.1 CDS MMAR_5107 NC_010612.1 6186786 6188138 R transmembrane protein rich in alanine, arginine and proline complement(6186786..6188138) Mycobacterium marinum M 6229398 YP_001853367.1 CDS MMAR_5108 NC_010612.1 6188250 6188726 R hypothetical protein complement(6188250..6188726) Mycobacterium marinum M 6229399 YP_001853368.1 CDS folK NC_010612.1 6188726 6189253 R involved in dihydrofolate biosynthesis (at the first step) [catalytic activity: ATP + 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8- dihydro-4-hydroxy-6-(diphosphooxymethyl)pteri di ne]; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(6188726..6189253) Mycobacterium marinum M 6229400 YP_001853369.1 CDS folB NC_010612.1 6189250 6189651 R involved in folate biosynthesis. catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8- dihydropterin (by similarity) [catalytic activity: 2-amino- 4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7, 8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine + glycolaldehyde]; dihydroneopterin aldolase FolB complement(6189250..6189651) Mycobacterium marinum M 6229401 YP_001853370.1 CDS folP1 NC_010612.1 6189644 6190486 R involved in dihydrofolate biosynthesis (at the second step). catalyzes the formation of the immediate precursor of folic acid. it is implicated in resistance to sulfonamide [catalytic activity: 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine diphosphate + 4- aminobenzoate = pyrophosphate + dihydropteroate]; dihydropteroate synthase 1 FolP1 complement(6189644..6190486) Mycobacterium marinum M 6229402 YP_001853371.1 CDS folE NC_010612.1 6190483 6191091 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(6190483..6191091) Mycobacterium marinum M 6229403 YP_001853372.1 CDS ftsH NC_010612.1 6191108 6193348 R thought to act as an ATP-dependent zinc metallopeptidase, with ATPase and proteolytic activities. probably has a regulatory role in stress response and specific proteins secretion for adaptation to host environment; membrane-bound protease FtsH complement(6191108..6193348) Mycobacterium marinum M 6229404 YP_001853373.1 CDS ephA NC_010612.1 6193588 6194556 D biotransformation enzyme that catalyzes the hydrolysis of epoxides (alkene oxides, oxiranes) and Arene oxides to less reactive and more water soluble dihydrodiols by the trans addition of water. thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphA 6193588..6194556 Mycobacterium marinum M 6229405 YP_001853374.1 CDS MMAR_5115 NC_010612.1 6194553 6195743 D monooxygenase 6194553..6195743 Mycobacterium marinum M 6229406 YP_001853375.1 CDS MMAR_5116 NC_010612.1 6195743 6196756 D function unknown; probably involved in cellular metabolism; dehydrogenase 6195743..6196756 Mycobacterium marinum M 6229407 YP_001853376.1 CDS MMAR_5117 NC_010612.1 6196788 6198044 R PPE family protein complement(6196788..6198044) Mycobacterium marinum M 6229408 YP_001853377.1 CDS MMAR_5118 NC_010612.1 6198057 6198356 R PE family protein complement(6198057..6198356) Mycobacterium marinum M 6229409 YP_001853378.1 CDS esxN_2 NC_010612.1 6199053 6199337 R EsaT-6 like protein EsxN_2 complement(6199053..6199337) Mycobacterium marinum M 6229410 YP_001853379.1 CDS esxP_1 NC_010612.1 6199376 6199672 R EsaT-6 like protein EsxP complement(6199376..6199672) Mycobacterium marinum M 6229411 YP_001853380.1 CDS MMAR_5121 NC_010612.1 6199804 6201045 R PPE family protein complement(6199804..6201045) Mycobacterium marinum M 6229412 YP_001853381.1 CDS MMAR_5122 NC_010612.1 6201059 6201358 R PE family protein complement(6201059..6201358) Mycobacterium marinum M 6229413 YP_001853382.1 CDS lpqG NC_010612.1 6202176 6202922 D lipoprotein LpqG 6202176..6202922 Mycobacterium marinum M 6229414 YP_001853383.1 CDS hpt NC_010612.1 6202948 6203556 R involved in purine salvage [catalytic activity: imp + pyrophosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (guanine can replace hypoxanthine to produce GMP)]; hypoxanthine-guanine phosphoribosyltransferase Hpt complement(6202948..6203556) Mycobacterium marinum M 6229415 YP_001853384.1 CDS mesJ NC_010612.1 6203610 6204581 R predicted ATPase of the PP-loop superfamily implicated in cell cycle control; cell cycle protein MesJ complement(6203610..6204581) Mycobacterium marinum M 6229416 YP_001853385.1 CDS MMAR_5126 NC_010612.1 6204560 6205618 R hypothetical protein complement(6204560..6205618) Mycobacterium marinum M 6229417 YP_001853386.1 CDS dacB1 NC_010612.1 6205615 6207000 R involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; D-alanyl-D-alanine carboxypeptidase complement(6205615..6207000) Mycobacterium marinum M 6229418 YP_001853387.1 CDS ppa NC_010612.1 6207141 6207629 D involved in the function of cellular bioenergetics [catalytic activity: pyrophosphate + H(2)O = 2 orthophosphate]; inorganic pyrophosphatase Ppa 6207141..6207629 Mycobacterium marinum M 6229419 YP_001853388.1 CDS MMAR_5129 NC_010612.1 6207638 6208714 R hypothetical protein complement(6207638..6208714) Mycobacterium marinum M 6229420 YP_001853389.1 CDS MMAR_5130 NC_010612.1 6208879 6210153 D hypothetical protein 6208879..6210153 Mycobacterium marinum M 6229421 YP_001853390.1 CDS MMAR_5131 NC_010612.1 6210201 6210902 D function unknown, the domain detected in this CDS is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family protein 6210201..6210902 Mycobacterium marinum M 6229422 YP_001853391.1 CDS MMAR_5132 NC_010612.1 6210899 6211240 D hypothetical protein 6210899..6211240 Mycobacterium marinum M 6229423 YP_001853392.1 CDS galE1 NC_010612.1 6211256 6212200 R involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose]; UDP-glucose 4-epimerase GalE1 complement(6211256..6212200) Mycobacterium marinum M 6229424 YP_001853393.1 CDS MMAR_5134 NC_010612.1 6212233 6214017 D hypothetical protein 6212233..6214017 Mycobacterium marinum M 6229425 YP_001853394.1 CDS MMAR_5135 NC_010612.1 6214159 6216204 D PE-PGRS family protein 6214159..6216204 Mycobacterium marinum M 6229426 YP_001853395.1 CDS MMAR_5136 NC_010612.1 6216373 6217590 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' complement(6216373..6217590) Mycobacterium marinum M 6229428 YP_001853396.1 CDS MMAR_5137 NC_010612.1 6217734 6219323 D C-term contains an adenylyl/guanylyl cyclase domain. may catalyze the formation of cyclic AMP/GMP from ATP/GTP; adenylate cyclase 6217734..6219323 Mycobacterium marinum M 6229429 YP_001853397.1 CDS topA NC_010612.1 6219334 6222138 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(6219334..6222138) Mycobacterium marinum M 6229430 YP_001853398.1 CDS MMAR_5139 NC_010612.1 6222342 6222920 R hypothetical protein complement(6222342..6222920) Mycobacterium marinum M 6229431 YP_001853399.1 CDS cspA_1 NC_010612.1 6223065 6223268 R possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures); cold-shock protein complement(6223065..6223268) Mycobacterium marinum M 6229432 YP_001853400.1 CDS MMAR_5141 NC_010612.1 6223517 6225832 D function unknown. helicases are involved in unwinding nucleic acids. the DeaD box helicases are involved in various aspects of RNA metabolism; DEAD/DEAH box helicase 6223517..6225832 Mycobacterium marinum M 6229433 YP_001853401.1 CDS MMAR_5142 NC_010612.1 6226324 6227355 D hypothetical protein 6226324..6227355 Mycobacterium marinum M 6229434 YP_001853402.1 CDS MMAR_5143 NC_010612.1 6227364 6227687 R hypothetical protein complement(6227364..6227687) Mycobacterium marinum M 6229435 YP_001853403.1 CDS MMAR_5577 NC_010612.1 6227719 6227985 R hypothetical protein complement(6227719..6227985) Mycobacterium marinum M 6229436 YP_001853404.1 CDS MMAR_5144 NC_010612.1 6228042 6228242 R hypothetical protein complement(6228042..6228242) Mycobacterium marinum M 6229437 YP_001853405.1 CDS MMAR_5145 NC_010612.1 6228267 6228869 R hypothetical protein complement(6228267..6228869) Mycobacterium marinum M 6229438 YP_001853406.1 CDS MMAR_5146 NC_010612.1 6228895 6229698 R function unknown, contains domain identity to Flp pilus assembly protein TadB; hypothetical protein complement(6228895..6229698) Mycobacterium marinum M 6229439 YP_001853407.1 CDS MMAR_5147 NC_010612.1 6229695 6230864 R function unknown, contains domain identity with Flp pilus assembly protein, ATPase CpaF; hypothetical protein complement(6229695..6230864) Mycobacterium marinum M 6229440 YP_001853408.1 CDS MMAR_5148 NC_010612.1 6230861 6231970 R function unknown, has a P-loop containing nucleoside triphosphate hydrolase superfamily domain; hypothetical protein complement(6230861..6231970) Mycobacterium marinum M 6229441 YP_001853409.1 CDS serB NC_010612.1 6232446 6233303 D phosphoserine + H(2)O <=> serine + phosphate; phosphoserine phosphatase SerB 6232446..6233303 Mycobacterium marinum M 6229442 YP_001853410.1 CDS MMAR_5556 NC_010612.1 6233429 6233743 R hypothetical protein complement(6233429..6233743) Mycobacterium marinum M 6229443 YP_001853411.1 CDS MMAR_5150 NC_010612.1 6233796 6234566 R hypothetical protein complement(6233796..6234566) Mycobacterium marinum M 6229444 YP_001853412.1 CDS dppD NC_010612.1 6234578 6236233 R involved in active transport of dipeptides across the membrane (import). responsible for energy coupling to the transport system; dipeptide-transport ATP-binding protein ABC transporter DppD complement(6234578..6236233) Mycobacterium marinum M 6229445 YP_001853413.1 CDS dppC NC_010612.1 6236230 6237093 R involved in active transport of dipeptide across the membrane (import). responsible for the translocation of the substrate across the membrane; dipeptide-transport integral membrane protein ABC transporter DppC complement(6236230..6237093) Mycobacterium marinum M 6229446 YP_001853414.1 CDS dppB NC_010612.1 6237086 6238012 R involved in active transport of dipeptide across the membrane (import). responsible for the translocation of the substrate across the membrane; dipeptide-transport integral membrane protein ABC transporter DppB complement(6237086..6238012) Mycobacterium marinum M 6229447 YP_001853415.1 CDS dppA NC_010612.1 6238014 6239633 R thought to be involved in active transport of dipeptide across the membrane (import); periplasmic dipeptide-binding lipoprotein DppA complement(6238014..6239633) Mycobacterium marinum M 6229448 YP_001853416.1 CDS acs NC_010612.1 6239844 6241799 D Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 6239844..6241799 Mycobacterium marinum M 6229449 YP_001853417.1 CDS MMAR_5156 NC_010612.1 6241808 6242506 R function unknown, domain identity suggests peptidase, trypsin-like serine or cysteine protease. contains peptidase S1B, active site; hypothetical protein complement(6241808..6242506) Mycobacterium marinum M 6229450 YP_001853418.1 CDS MMAR_5157 NC_010612.1 6242732 6243250 D hypothetical protein 6242732..6243250 Mycobacterium marinum M 6229451 YP_001853419.1 CDS ephE NC_010612.1 6243251 6244216 D thought to be involved in detoxification reactions following oxidative damage to lipids. biotransformation enzyme that catalyzes the hydrolysis of epoxides: aromatic hydrocarbons catabolism [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphE 6243251..6244216 Mycobacterium marinum M 6229452 YP_001853420.1 CDS MMAR_5159 NC_010612.1 6244209 6245411 R function unknown, hydrolyses of peptides and/or proteins (possibly cleaved preferentially after serine residue). contains peptidase S1B, active site; membrane-associated serine protease complement(6244209..6245411) Mycobacterium marinum M 6229453 YP_001853421.1 CDS MMAR_5160 NC_010612.1 6245408 6246226 R function unknown: contains a NUDIX domain; hypothetical protein complement(6245408..6246226) Mycobacterium marinum M 6229454 YP_001853422.1 CDS MMAR_5161 NC_010612.1 6246223 6246876 R function unknown, contains a N-term thioredoxin domain. may serve as a general protein disulphide oxidoreductase; membrane-anchored thioredoxin-like protein complement(6246223..6246876) Mycobacterium marinum M 6229455 YP_001853423.1 CDS nth NC_010612.1 6246887 6247669 R has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. incises damaged DNA at cytosines, thymines and guanines. acts on a damaged strand (oxidized pyrimidines), 5' from the damaged site [catalytic activity: endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate]; endonuclease III Nth complement(6246887..6247669) Mycobacterium marinum M 6229456 YP_001853424.1 CDS MMAR_5163 NC_010612.1 6247741 6248109 D hypothetical protein 6247741..6248109 Mycobacterium marinum M 6229457 YP_001853425.1 CDS MMAR_5164 NC_010612.1 6248208 6248882 D involved in transcriptional mechanism; regulatory protein 6248208..6248882 Mycobacterium marinum M 6229458 YP_001853426.1 CDS MMAR_5165 NC_010612.1 6248879 6249685 R function unknown, probably involved in cellular metabolism; hypothetical protein complement(6248879..6249685) Mycobacterium marinum M 6229459 YP_001853427.1 CDS MMAR_5166 NC_010612.1 6249691 6250146 R function unknown, this endoribonuclease domain is active on single-stranded mRNA and inhibits protein synthesis by cleavage of mRNA; hypothetical protein complement(6249691..6250146) Mycobacterium marinum M 6229460 YP_001853428.1 CDS MMAR_5167 NC_010612.1 6250168 6250329 R hypothetical protein complement(6250168..6250329) Mycobacterium marinum M 6229461 YP_001853429.1 CDS MMAR_5168 NC_010612.1 6250406 6251428 D function unknown, may catalyze the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)]; anion transporter ATPase 6250406..6251428 Mycobacterium marinum M 6229462 YP_001853430.1 CDS MMAR_5169 NC_010612.1 6251425 6252585 D anion-transporting ATPase; supposed catalyzes the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)]; anion transporter ATPase 6251425..6252585 Mycobacterium marinum M 6229463 YP_001853431.1 CDS whiB4 NC_010612.1 6252734 6253084 R involved in a transcriptional mechanism; transcriptional regulatory protein Whib-like WhiB4 complement(6252734..6253084) Mycobacterium marinum M 6229464 YP_001853432.1 CDS ponA2 NC_010612.1 6253445 6255856 D involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits); bifunctional membrane-associated penicillin- binding protein 1A/1B PonA2 6253445..6255856 Mycobacterium marinum M 6229465 YP_001853433.1 CDS MMAR_5172 NC_010612.1 6255923 6256936 D function unknown, contains metallophosphoesterase domain; hypothetical protein 6255923..6256936 Mycobacterium marinum M 6229466 YP_001853434.1 CDS cysK NC_010612.1 6256933 6258039 D function unknown, probably involved in cellular metabolism. reaction catalysed: O(3)-acetyl-L-serine + H(2)S <=> L-cysteine + acetate; cysteine synthase 6256933..6258039 Mycobacterium marinum M 6229467 YP_001853435.1 CDS MMAR_5174 NC_010612.1 6258210 6258461 R hypothetical protein complement(6258210..6258461) Mycobacterium marinum M 6229469 YP_001853436.1 CDS cyp137A2 NC_010612.1 6258532 6259902 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 137A2 Cyp137A2 complement(6258532..6259902) Mycobacterium marinum M 6229470 YP_001853437.1 CDS MMAR_5176 NC_010612.1 6259942 6260253 R hypothetical protein complement(6259942..6260253) Mycobacterium marinum M 6229471 YP_001853438.1 CDS MMAR_5177 NC_010612.1 6260343 6260603 R hypothetical protein complement(6260343..6260603) Mycobacterium marinum M 6229472 YP_001853439.1 CDS MMAR_5178 NC_010612.1 6260744 6261343 R function unknown; contains pas domain. this is usually associated with the input domain of a histidine kinase, or a sensor protein that regulates a histidine kinase; putative response regulatory protein complement(6260744..6261343) Mycobacterium marinum M 6229473 YP_001853440.1 CDS MMAR_5180 NC_010612.1 6261634 6262143 R hypothetical protein complement(6261634..6262143) Mycobacterium marinum M 6229474 YP_001853441.1 CDS MMAR_5181 NC_010612.1 6262215 6262583 R function unknown; potential role in regulation of transcription; anti-anti-sigma regulatory factor complement(6262215..6262583) Mycobacterium marinum M 6229475 YP_001853442.1 CDS MMAR_5182 NC_010612.1 6262743 6263639 D function unknown; potential role in regulation of transcription; anti-anti-sigma regulatory factor 6262743..6263639 Mycobacterium marinum M 6229476 YP_001853443.1 CDS MMAR_5183 NC_010612.1 6263671 6264060 D function unknown; contains an anti-anti-sigma regulatory factor domain. may have a role in a signal transduction mechanism; hypothetical protein 6263671..6264060 Mycobacterium marinum M 6229477 YP_001853444.1 CDS MMAR_5184 NC_010612.1 6264065 6264460 D function unknown; contains a kinase domain. possible role in signal transduction mechanism; putative regulatory protein 6264065..6264460 Mycobacterium marinum M 6229478 YP_001853445.1 CDS MMAR_5185 NC_010612.1 6264453 6265079 D function unknown; contains a sigma factor PP2C-like phosphatase domain. probably part of a signal transduction locus; putative regulatory protein 6264453..6265079 Mycobacterium marinum M 6229479 YP_001853446.1 CDS MMAR_5186 NC_010612.1 6265076 6267304 D sensor-component of a two-component regulator 6265076..6267304 Mycobacterium marinum M 6229480 YP_001853447.1 CDS MMAR_5187 NC_010612.1 6267324 6268850 R function unknown. thought to be regulated by LexA; 13e12 repeat-containing protein complement(6267324..6268850) Mycobacterium marinum M 6229481 YP_001853448.1 CDS MMAR_5188 NC_010612.1 6268894 6269448 R function unknown; domain homology suggests a role as an intracellular protease/amidase; hypothetical protein complement(6268894..6269448) Mycobacterium marinum M 6229482 YP_001853449.1 CDS MMAR_5189 NC_010612.1 6269640 6270656 R involved in thiamine biosynthesis [catalytic activity: ATP + thiamine phosphate = ADP + thiamine diphosphate]; thiamine-monophosphate kinase complement(6269640..6270656) Mycobacterium marinum M 6229483 YP_001853450.1 CDS selA NC_010612.1 6270798 6272099 D catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 6270798..6272099 Mycobacterium marinum M 6229485 YP_001853451.1 CDS selB NC_010612.1 6272087 6273802 D this protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; selenocysteine-specific translation elongation factor, SelB 6272087..6273802 Mycobacterium marinum M 6229486 YP_001853452.1 CDS MMAR_5192 NC_010612.1 6273353 6275248 R function unknown; extensive overlap with D/S CDS on opposite strand; integral membrane transport protein complement(6273353..6275248) Mycobacterium marinum M 6229487 YP_001853453.1 CDS MMAR_5193 NC_010612.1 6275290 6275940 D hypothetical protein 6275290..6275940 Mycobacterium marinum M 6229488 YP_001853454.1 CDS MMAR_5194 NC_010612.1 6276023 6276604 D function unknown; potential role in anaerobic electron transport chain. contains formate dehydrogenase/DMSO reductase superfamily domain; formate dehydrogenase subunit alpha, selenocysteine-containing 6276023..6276604 Mycobacterium marinum M 6229489 YP_001853455.1 CDS MMAR_5195 NC_010612.1 6276701 6279217 D function unknown; potential role in anaerobic electron transport chain; formate dehydrogenase subunit beta, selenocysteine-containing 6276701..6279217 Mycobacterium marinum M 6229490 YP_001853456.1 CDS hybA NC_010612.1 6279214 6280104 D Fe-S-cluster-containing hydrogenase, HybA 6279214..6280104 Mycobacterium marinum M 6229491 YP_001853457.1 CDS nrfD NC_010612.1 6280101 6281072 D NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway; formate-dependent nitrite reductase, membrane component, NrfD 6280101..6281072 Mycobacterium marinum M 6229492 YP_001853458.1 CDS MMAR_5198 NC_010612.1 6281083 6281547 R function unknown, contains GatB/Yqey domain. this domain is found at the C terminus of GatB which transamidates glu-tRNA to Gln-tRNA; hypothetical protein complement(6281083..6281547) Mycobacterium marinum M 6229493 YP_001853459.1 CDS MMAR_5199 NC_010612.1 6281665 6282927 D hypothetical protein 6281665..6282927 Mycobacterium marinum M 6229494 YP_001853460.1 CDS MMAR_5200 NC_010612.1 6282948 6283598 D hypothetical protein 6282948..6283598 Mycobacterium marinum M 6229495 YP_001853461.1 CDS MMAR_5201 NC_010612.1 6283598 6284737 D hypothetical protein 6283598..6284737 Mycobacterium marinum M 6229496 YP_001853462.1 CDS moxR2 NC_010612.1 6284734 6285711 D involved in transcriptional mechanism; regulates methanol dehydrogenase; methanol dehydrogenase transcriptional regulatory protein MoxR2 6284734..6285711 Mycobacterium marinum M 6229497 YP_001853463.1 CDS MMAR_5203 NC_010612.1 6285711 6287033 D function unknown, contains N-term signal peptide; hypothetical protein 6285711..6287033 Mycobacterium marinum M 6229498 YP_001853464.1 CDS MMAR_5204 NC_010612.1 6287038 6288030 R hypothetical protein complement(6287038..6288030) Mycobacterium marinum M 6229499 YP_001853465.1 CDS MMAR_5205 NC_010612.1 6288135 6289040 D function unknown, contains RDD domain RDD family. the molecular function of this region is unknown. however this region may be involved in transport of an as yet unknown set of ligands; hypothetical protein 6288135..6289040 Mycobacterium marinum M 6229500 YP_001853466.1 CDS MMAR_5206 NC_010612.1 6289174 6289878 D PadR-like transcriptional regulatory protein 6289174..6289878 Mycobacterium marinum M 6229501 YP_001853467.1 CDS MMAR_5207 NC_010612.1 6290038 6292578 D PE-PGRS family protein 6290038..6292578 Mycobacterium marinum M 6229502 YP_001853468.1 CDS glpK NC_010612.1 6292586 6294112 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(6292586..6294112) Mycobacterium marinum M 6229503 YP_001853469.1 CDS MMAR_5209 NC_010612.1 6294247 6295728 D hypothetical protein 6294247..6295728 Mycobacterium marinum M 6229504 YP_001853470.1 CDS MMAR_5210 NC_010612.1 6295739 6296437 D function unknown; contains thiopurine S- methyltransferase domain. this is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds; hypothetical protein 6295739..6296437 Mycobacterium marinum M 6229505 YP_001853471.1 CDS csdB NC_010612.1 6296453 6297604 R probable role in the metabolism of proteins containing the rare amino acid selenocysteine; selenocysteine lyase, CsdB complement(6296453..6297604) Mycobacterium marinum M 6229506 YP_001853472.1 CDS MMAR_5212 NC_010612.1 6297601 6298566 R s-adenosyl-L-methionine- dependentmethyltransferase complement(6297601..6298566) Mycobacterium marinum M 6229507 YP_001853473.1 CDS MMAR_5213 NC_010612.1 6298563 6299276 R function unknown, contains N-terminal nucleophile aminohydrolase superfamily domain; hypothetical protein complement(6298563..6299276) Mycobacterium marinum M 6229508 YP_001853474.1 CDS MMAR_5214 NC_010612.1 6299276 6300577 R hypothetical protein complement(6299276..6300577) Mycobacterium marinum M 6229509 YP_001853475.1 CDS gshA NC_010612.1 6300574 6301863 R involved in glutathione biosynthesis (at the first step) [catalytic activity: ATP + L-glutamate + L-cysteine = ADP + orthophosphate + gamma-L-glutamyl-L-cysteine]; glutamate--cysteine ligase GshA complement(6300574..6301863) Mycobacterium marinum M 6229510 YP_001853476.1 CDS MMAR_5216 NC_010612.1 6302011 6302676 R hypothetical protein complement(6302011..6302676) Mycobacterium marinum M 6229511 YP_001853477.1 CDS katE NC_010612.1 6302706 6304154 R protects against oxidative stress. converts hydrogen peroxide to water and molecular oxygen; catalase KatE complement(6302706..6304154) Mycobacterium marinum M 6229512 YP_001853478.1 CDS MMAR_5218 NC_010612.1 6304329 6304766 R function unknown, rich in short repeat motifs; hypothetical protein complement(6304329..6304766) Mycobacterium marinum M 6229513 YP_001853479.1 CDS MMAR_5219 NC_010612.1 6304885 6305232 R function unknown, rich in short repeat motifs; hypothetical protein complement(6304885..6305232) Mycobacterium marinum M 6229514 YP_001853480.1 CDS MMAR_5220 NC_010612.1 6305375 6306511 R hypothetical protein complement(6305375..6306511) Mycobacterium marinum M 6229515 YP_001853481.1 CDS asd NC_010612.1 6306519 6307577 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(6306519..6307577) Mycobacterium marinum M 6229516 YP_001853482.1 CDS ask NC_010612.1 6307579 6308844 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase complement(6307579..6308844) Mycobacterium marinum M 6229517 YP_001853483.1 CDS MMAR_5223 NC_010612.1 6309196 6312801 D thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; drug-transport transmembrane ABC transporter ATP-binding protein 6309196..6312801 Mycobacterium marinum M 6229518 YP_001853484.1 CDS MMAR_5224 NC_010612.1 6312808 6314700 R hypothetical protein complement(6312808..6314700) Mycobacterium marinum M 6229519 YP_001853485.1 CDS leuA NC_010612.1 6315323 6317143 D involved in leucine biosynthesis (at the first step). catalyzes condensation of acetyl-CoA and 2- oxoisovalerate to form 2-isopropylmalate synthase [catalytic activity: 3-carboxy-3-hydroxy-4- methylpentanoate + CoA = acetyl-CoA + 3-methyl-2- oxobutanoate + H(2)O]; 2-isopropylmalate synthase 6315323..6317143 Mycobacterium marinum M 6229520 YP_001853486.1 CDS MMAR_5226 NC_010612.1 6317140 6317703 R involved in transcriptional mechanism; DeoR family transcriptional regulator complement(6317140..6317703) Mycobacterium marinum M 6229521 YP_001853487.1 CDS MMAR_5227 NC_010612.1 6317703 6318152 R function unknown, contains multidrug efflux transporter AcrB transmembrane superfamily domain; hypothetical protein complement(6317703..6318152) Mycobacterium marinum M 6229522 YP_001853488.1 CDS dnaQ NC_010612.1 6318199 6319188 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(6318199..6319188) Mycobacterium marinum M 6229523 YP_001853489.1 CDS MMAR_5229 NC_010612.1 6319421 6320575 D possible role in cell wall peptidoglycan biogenesis. contains Mur ligase family catalytic domain. possible UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase, required for the formation of the UDP- MurNAc-linked pentapeptide by addition of the D-Ala-D-Ala subgroup; UDP-N-acetylmuramyl tripeptide synthase 6319421..6320575 Mycobacterium marinum M 6229524 YP_001853490.1 CDS cobQ2 NC_010612.1 6320568 6321275 D involved in cobalamin biosynthesis. catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic a,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (by similarity); cobyric acid synthase CobQ2 6320568..6321275 Mycobacterium marinum M 6229525 YP_001853491.1 CDS recR NC_010612.1 6321291 6321902 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(6321291..6321902) Mycobacterium marinum M 6229526 YP_001853492.1 CDS MMAR_5232 NC_010612.1 6321914 6322357 R hypothetical protein complement(6321914..6322357) Mycobacterium marinum M 6229527 YP_001853493.1 CDS MMAR_5233 NC_010612.1 6322492 6323217 D hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides; N-acetylmuramoyl-L-alanine amidase 6322492..6323217 Mycobacterium marinum M 6229528 YP_001853494.1 CDS MMAR_5234 NC_010612.1 6323214 6323651 R function unknown, contains bet v1-like superfamily domain; hypothetical protein complement(6323214..6323651) Mycobacterium marinum M 6229529 YP_001853495.1 CDS MMAR_5235 NC_010612.1 6323698 6325110 D dehydrogenase 6323698..6325110 Mycobacterium marinum M 6229530 YP_001853496.1 CDS MMAR_5236 NC_010612.1 6325107 6326426 D cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase catalyses the reaction: S-adenosyl-L- methionine + phospholipid olefinic fatty acid -> S- adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. CFA synthase is closely related to methyltransferases; cyclopropane-fatty-acyl-phospholipid synthase 6325107..6326426 Mycobacterium marinum M 6229531 YP_001853497.1 CDS MMAR_5237 NC_010612.1 6326439 6326681 D hypothetical protein 6326439..6326681 Mycobacterium marinum M 6229532 YP_001853498.1 CDS MMAR_5238 NC_010612.1 6326720 6327223 D hypothetical protein 6326720..6327223 Mycobacterium marinum M 6229533 YP_001853499.1 CDS MMAR_5239 NC_010612.1 6327220 6327696 D hypothetical protein 6327220..6327696 Mycobacterium marinum M 6229534 YP_001853500.1 CDS dnaZX NC_010612.1 6327745 6329646 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(6327745..6329646) Mycobacterium marinum M 6229535 YP_001853501.1 CDS MMAR_5241 NC_010612.1 6329705 6330991 R transcriptional regulator complement(6329705..6330991) Mycobacterium marinum M 6229536 YP_001853502.1 CDS MMAR_5242 NC_010612.1 6331436 6332278 D hypothetical protein 6331436..6332278 Mycobacterium marinum M 6229538 YP_001853503.1 CDS echA3_1 NC_010612.1 6332310 6333056 R oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA3 complement(6332310..6333056) Mycobacterium marinum M 6229539 YP_001853504.1 CDS MMAR_5244 NC_010612.1 6333157 6333642 D 19 kDa lipoprotein antigen LpqH-like protein 6333157..6333642 Mycobacterium marinum M 6229540 YP_001853505.1 CDS MMAR_5245 NC_010612.1 6333642 6335459 D hypothetical protein 6333642..6335459 Mycobacterium marinum M 6229541 YP_001853506.1 CDS MMAR_5246 NC_010612.1 6335456 6336829 D hypothetical protein 6335456..6336829 Mycobacterium marinum M 6229542 YP_001853507.1 CDS MMAR_5247 NC_010612.1 6336833 6337276 R hypothetical protein complement(6336833..6337276) Mycobacterium marinum M 6229543 YP_001853508.1 CDS MMAR_5248 NC_010612.1 6337361 6338692 D hypothetical protein 6337361..6338692 Mycobacterium marinum M 6229544 YP_001853509.1 CDS MMAR_5249 NC_010612.1 6338689 6339843 D hypothetical protein 6338689..6339843 Mycobacterium marinum M 6229545 YP_001853510.1 CDS MMAR_5250 NC_010612.1 6339884 6340981 D hypothetical protein 6339884..6340981 Mycobacterium marinum M 6229546 YP_001853511.1 CDS cut5 NC_010612.1 6341094 6341789 D hydrolysis of cutin (a polyester that forms the structure of plant cuticle); cutinase 6341094..6341789 Mycobacterium marinum M 6229547 YP_001853512.1 CDS MMAR_5252 NC_010612.1 6341830 6342822 D function unknown, probably involved in cellular metabolism; oxidoreductase 6341830..6342822 Mycobacterium marinum M 6229548 YP_001853513.1 CDS MMAR_5253 NC_010612.1 6343019 6343402 R hypothetical protein complement(6343019..6343402) Mycobacterium marinum M 6229549 YP_001853514.1 CDS MMAR_5254 NC_010612.1 6343503 6346673 R involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase; membrane-anchored adenylyl cyclase complement(6343503..6346673) Mycobacterium marinum M 6229550 YP_001853515.1 CDS MMAR_5255 NC_010612.1 6346806 6347117 D hypothetical protein 6346806..6347117 Mycobacterium marinum M 6229551 YP_001853516.1 CDS MMAR_5256 NC_010612.1 6347114 6347692 D hypothetical protein 6347114..6347692 Mycobacterium marinum M 6229552 YP_001853517.1 CDS MMAR_5257 NC_010612.1 6347712 6350888 R involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase; membrane-anchored adenylyl cyclase complement(6347712..6350888) Mycobacterium marinum M 6229553 YP_001853518.1 CDS MMAR_5258 NC_010612.1 6351135 6351446 D PE family protein 6351135..6351446 Mycobacterium marinum M 6229554 YP_001853519.1 CDS MMAR_5259 NC_010612.1 6351446 6352732 D PPE family protein 6351446..6352732 Mycobacterium marinum M 6229555 YP_001853520.1 CDS MMAR_5260 NC_010612.1 6352735 6353145 R hypothetical protein complement(6352735..6353145) Mycobacterium marinum M 6229556 YP_001853521.1 CDS MMAR_5261 NC_010612.1 6353367 6354014 D hypothetical protein 6353367..6354014 Mycobacterium marinum M 6229557 YP_001853522.1 CDS MMAR_5262 NC_010612.1 6354082 6354405 D hypothetical protein 6354082..6354405 Mycobacterium marinum M 6229558 YP_001853523.1 CDS MMAR_5263 NC_010612.1 6354545 6355204 D hypothetical protein 6354545..6355204 Mycobacterium marinum M 6229559 YP_001853524.1 CDS MMAR_5265 NC_010612.1 6355855 6356895 R hypothetical protein complement(6355855..6356895) Mycobacterium marinum M 6229560 YP_001853525.1 CDS ligC NC_010612.1 6356933 6358009 D catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase 6356933..6358009 Mycobacterium marinum M 6229561 YP_001853526.1 CDS MMAR_5267 NC_010612.1 6358108 6358692 D hypothetical protein 6358108..6358692 Mycobacterium marinum M 6229562 YP_001853527.1 CDS cyp164A3 NC_010612.1 6358713 6360041 R cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 164A3 Cyp164A3 complement(6358713..6360041) Mycobacterium marinum M 6229563 YP_001853528.1 CDS MMAR_5269 NC_010612.1 6360049 6361143 D hypothetical protein 6360049..6361143 Mycobacterium marinum M 6229564 YP_001853529.1 CDS MMAR_5270 NC_010612.1 6361163 6361645 R hypothetical protein complement(6361163..6361645) Mycobacterium marinum M 6229565 YP_001853530.1 CDS MMAR_5271 NC_010612.1 6361653 6363017 R hypothetical protein complement(6361653..6363017) Mycobacterium marinum M 6229566 YP_001853531.1 CDS acrA1_1 NC_010612.1 6363087 6364166 R function unknown, involved in cellular metabolism; multi-functional enzyme with acyl-CoA-reductase activity AcrA1 complement(6363087..6364166) Mycobacterium marinum M 6229567 YP_001853532.1 CDS MMAR_5273 NC_010612.1 6364351 6365157 D hypothetical protein 6364351..6365157 Mycobacterium marinum M 6229568 YP_001853533.1 CDS MMAR_5274 NC_010612.1 6365202 6365711 D hypothetical protein 6365202..6365711 Mycobacterium marinum M 6229569 YP_001853534.1 CDS fadD15_1 NC_010612.1 6365728 6367530 R function unknown, but involved in lipid degradation; long-chain-fatty-acid-CoA ligase FadD15 complement(6365728..6367530) Mycobacterium marinum M 6229570 YP_001853535.1 CDS MMAR_5276 NC_010612.1 6367791 6368810 D involved in transcriptional mechanism; AraC/XylS family transcriptional regulator 6367791..6368810 Mycobacterium marinum M 6229571 YP_001853536.1 CDS MMAR_5277 NC_010612.1 6368838 6370061 R PPE family protein complement(6368838..6370061) Mycobacterium marinum M 6229572 YP_001853537.1 CDS MMAR_5278 NC_010612.1 6370161 6371519 R hypothetical protein complement(6370161..6371519) Mycobacterium marinum M 6229573 YP_001853538.1 CDS MMAR_5279 NC_010612.1 6371563 6373062 R function unknown role in oxidoreduction; monooxygenase-like flavoprotein complement(6371563..6373062) Mycobacterium marinum M 6229574 YP_001853539.1 CDS MMAR_5280 NC_010612.1 6373368 6374453 D hypothetical protein 6373368..6374453 Mycobacterium marinum M 6229575 YP_001853540.1 CDS MMAR_5281 NC_010612.1 6374450 6375223 D short chain dehydrogenase 6374450..6375223 Mycobacterium marinum M 6229576 YP_001853541.1 CDS serA4 NC_010612.1 6375258 6376292 R involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase complement(6375258..6376292) Mycobacterium marinum M 6229577 YP_001853542.1 CDS MMAR_5283 NC_010612.1 6376415 6380341 D involved in lipid metabolism; non-ribosomal peptide synthetase 6376415..6380341 Mycobacterium marinum M 6229578 YP_001853543.1 CDS pepN_1 NC_010612.1 6380338 6381663 D aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates); aminopeptidase N PepN 6380338..6381663 Mycobacterium marinum M 6229579 YP_001853544.1 CDS MMAR_5285 NC_010612.1 6381676 6382062 R hypothetical protein complement(6381676..6382062) Mycobacterium marinum M 6229580 YP_001853545.1 CDS MMAR_5286 NC_010612.1 6382127 6382462 R PE family protein complement(6382127..6382462) Mycobacterium marinum M 6229581 YP_001853546.1 CDS MMAR_5287 NC_010612.1 6383008 6383391 D hypothetical protein 6383008..6383391 Mycobacterium marinum M 6229582 YP_001853547.1 CDS MMAR_5288 NC_010612.1 6383521 6384270 R function unknown, supposed involvement in cellular metabolism; short-chain type dehydrogenase/reductase complement(6383521..6384270) Mycobacterium marinum M 6229583 YP_001853548.1 CDS MMAR_5289 NC_010612.1 6384267 6385505 R function unknown, probably involved in cellular metabolism; hydrolase complement(6384267..6385505) Mycobacterium marinum M 6229584 YP_001853549.1 CDS MMAR_5290 NC_010612.1 6385520 6386791 R hypothetical protein complement(6385520..6386791) Mycobacterium marinum M 6229585 YP_001853550.1 CDS MMAR_5291 NC_010612.1 6386920 6387405 D hypothetical protein 6386920..6387405 Mycobacterium marinum M 6229586 YP_001853551.1 CDS MMAR_5292 NC_010612.1 6387477 6387860 D hypothetical protein 6387477..6387860 Mycobacterium marinum M 6229587 YP_001853552.1 CDS MMAR_5293 NC_010612.1 6387920 6388279 D hypothetical protein 6387920..6388279 Mycobacterium marinum M 6229588 YP_001853553.1 CDS MMAR_5294 NC_010612.1 6388395 6395693 R PE-PGRS family protein complement(6388395..6395693) Mycobacterium marinum M 6229589 YP_001853554.1 CDS MMAR_5295 NC_010612.1 6396270 6396728 R function unknown, probably involved in deamination of specific substrate; cytidine/deoxycytidylate deaminase complement(6396270..6396728) Mycobacterium marinum M 6229591 YP_001853555.1 CDS MMAR_5296 NC_010612.1 6396725 6397246 R hypothetical protein complement(6396725..6397246) Mycobacterium marinum M 6229592 YP_001853556.1 CDS tyrA NC_010612.1 6397363 6398322 D catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 6397363..6398322 Mycobacterium marinum M 6229593 YP_001853557.1 CDS MMAR_5298 NC_010612.1 6398285 6398884 R hypothetical protein complement(6398285..6398884) Mycobacterium marinum M 6229594 YP_001853558.1 CDS proZ NC_010612.1 6398889 6399635 R thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ complement(6398889..6399635) Mycobacterium marinum M 6229595 YP_001853559.1 CDS proW NC_010612.1 6399632 6400312 R thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW complement(6399632..6400312) Mycobacterium marinum M 6229596 YP_001853560.1 CDS proV NC_010612.1 6400322 6401410 R thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for energy coupling to the transport system; osmoprotectant transport ATP-binding protein ABC transporter ProV complement(6400322..6401410) Mycobacterium marinum M 6229597 YP_001853561.1 CDS proX NC_010612.1 6401430 6402377 R thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import); osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX complement(6401430..6402377) Mycobacterium marinum M 6229598 YP_001853562.1 CDS MMAR_5303 NC_010612.1 6402493 6402870 D hypothetical protein 6402493..6402870 Mycobacterium marinum M 6229599 YP_001853563.1 CDS fadE36 NC_010612.1 6402932 6403984 R function unknown, but possibly involvement in lipid degradation; acyl-CoA dehydrogenase FadE36 complement(6402932..6403984) Mycobacterium marinum M 6229600 YP_001853564.1 CDS MMAR_5305 NC_010612.1 6404070 6404762 R hypothetical protein complement(6404070..6404762) Mycobacterium marinum M 6229601 YP_001853565.1 CDS MMAR_5306 NC_010612.1 6405085 6408345 D PE-PGRS family protein 6405085..6408345 Mycobacterium marinum M 6229602 YP_001853566.1 CDS MMAR_5307 NC_010612.1 6408534 6411728 D PE-PGRS family protein 6408534..6411728 Mycobacterium marinum M 6229603 YP_001853567.1 CDS MMAR_5308 NC_010612.1 6411991 6415230 D PE-PGRS family protein 6411991..6415230 Mycobacterium marinum M 6229604 YP_001853568.1 CDS MMAR_5309 NC_010612.1 6415312 6416364 D hypothetical protein 6415312..6416364 Mycobacterium marinum M 6229605 YP_001853569.1 CDS MMAR_5310 NC_010612.1 6416366 6417130 D function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 6416366..6417130 Mycobacterium marinum M 6229606 YP_001853570.1 CDS fadE1_1 NC_010612.1 6417148 6418455 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE1 6417148..6418455 Mycobacterium marinum M 6229607 YP_001853571.1 CDS MMAR_5312 NC_010612.1 6418452 6419054 D hypothetical protein 6418452..6419054 Mycobacterium marinum M 6229608 YP_001853572.1 CDS MMAR_5313 NC_010612.1 6419055 6420023 D possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone oxidoreductase 6419055..6420023 Mycobacterium marinum M 6229609 YP_001853573.1 CDS MMAR_5314 NC_010612.1 6420030 6421910 R function unknown, probably involved in cellular metabolism; hydrolase complement(6420030..6421910) Mycobacterium marinum M 6229610 YP_001853574.1 CDS lpqH NC_010612.1 6422276 6422575 D 19 kDa lipoprotein antigen precursor LpqH 6422276..6422575 Mycobacterium marinum M 6229611 YP_001853575.1 CDS tcrY NC_010612.1 6422689 6424203 R sensor part of a two-component regulatory system; two-component sensor kinase TcrY complement(6422689..6424203) Mycobacterium marinum M 6229612 YP_001853576.1 CDS tcrX NC_010612.1 6424181 6424888 R sensor part of a two-component regulatory system; two-component transcriptional regulatory protein TcrX complement(6424181..6424888) Mycobacterium marinum M 6229613 YP_001853577.1 CDS MMAR_5318 NC_010612.1 6425006 6425161 R hypothetical protein complement(6425006..6425161) Mycobacterium marinum M 6229614 YP_001853578.1 CDS MMAR_5319 NC_010612.1 6425173 6425496 R hypothetical protein complement(6425173..6425496) Mycobacterium marinum M 6229615 YP_001853579.1 CDS MMAR_5320 NC_010612.1 6425540 6425962 R hypothetical protein complement(6425540..6425962) Mycobacterium marinum M 6229616 YP_001853580.1 CDS MMAR_5321 NC_010612.1 6426029 6428200 R PE-PGRS family protein complement(6426029..6428200) Mycobacterium marinum M 6229617 YP_001853581.1 CDS MMAR_5322 NC_010612.1 6428344 6429825 R PE-PGRS family protein complement(6428344..6429825) Mycobacterium marinum M 6229618 YP_001853582.1 CDS MMAR_5323 NC_010612.1 6430000 6430944 R function unknown, may play a role in secondary metabolites biosynthesis, transport, and catabolism; O-methyltransferase complement(6430000..6430944) Mycobacterium marinum M 6229619 YP_001853583.1 CDS MMAR_5324 NC_010612.1 6431055 6431417 D hypothetical protein 6431055..6431417 Mycobacterium marinum M 6229620 YP_001853584.1 CDS MMAR_5325 NC_010612.1 6431423 6432451 D hypothetical protein 6431423..6432451 Mycobacterium marinum M 6229621 YP_001853585.1 CDS hisC2 NC_010612.1 6432837 6433922 D involved in histidine biosynthetic pathway (at the eighth step) [catalytic activity: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + glutamate]; putative aminotransferase 6432837..6433922 Mycobacterium marinum M 6229624 YP_001853586.1 CDS MMAR_5327 NC_010612.1 6433919 6434377 D hypothetical protein 6433919..6434377 Mycobacterium marinum M 6229625 YP_001853587.1 CDS MMAR_5328 NC_010612.1 6434403 6434987 R hypothetical protein complement(6434403..6434987) Mycobacterium marinum M 6229626 YP_001853588.1 CDS echA21 NC_010612.1 6435011 6435835 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 6435011..6435835 Mycobacterium marinum M 6229627 YP_001853589.1 CDS lipE NC_010612.1 6435872 6437116 D function unknown, lipolytic enzyme probably involved in cellular metabolism; lipase LipE 6435872..6437116 Mycobacterium marinum M 6229628 YP_001853590.1 CDS MMAR_5331 NC_010612.1 6437142 6439331 R PPE family protein complement(6437142..6439331) Mycobacterium marinum M 6229629 YP_001853591.1 CDS MMAR_5332 NC_010612.1 6439879 6440871 D function unknown, probably involved in cellular metabolism; oxidoreductase 6439879..6440871 Mycobacterium marinum M 6229631 YP_001853592.1 CDS MMAR_5333 NC_010612.1 6440911 6442107 R function unknown, probably involved in cellular metabolism; aminotransferase complement(6440911..6442107) Mycobacterium marinum M 6229633 YP_001853593.1 CDS MMAR_5334 NC_010612.1 6442238 6444211 D transmembrane protein 6442238..6444211 Mycobacterium marinum M 6229634 YP_001853594.1 CDS MMAR_5335 NC_010612.1 6444224 6444757 D hypothetical protein 6444224..6444757 Mycobacterium marinum M 6229635 YP_001853595.1 CDS rfbE NC_010612.1 6444761 6445603 D may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbD. responsible for energy coupling to the transport system; O-antigen/lipopolysaccharide transport ATP- binding protein ABC transporter RfbE 6444761..6445603 Mycobacterium marinum M 6229636 YP_001853596.1 CDS MMAR_5337 NC_010612.1 6445596 6446525 D possibly involved in rhamnose biosynthesis; L-rhamnosyltransferase 6445596..6446525 Mycobacterium marinum M 6229637 YP_001853597.1 CDS rfbD NC_010612.1 6446522 6447352 D may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbE. responsible for the translocation of the substrate across the membrane; O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD 6446522..6447352 Mycobacterium marinum M 6229638 YP_001853598.1 CDS MMAR_5339 NC_010612.1 6447485 6449287 D PE-PGRS family protein 6447485..6449287 Mycobacterium marinum M 6229639 YP_001853599.1 CDS MMAR_5340 NC_010612.1 6449408 6450769 R hypothetical protein complement(6449408..6450769) Mycobacterium marinum M 6229640 YP_001853600.1 CDS MMAR_5341 NC_010612.1 6451059 6454103 D PE-PGRS family protein 6451059..6454103 Mycobacterium marinum M 6229641 YP_001853601.1 CDS MMAR_5342 NC_010612.1 6454210 6454629 R hypothetical protein complement(6454210..6454629) Mycobacterium marinum M 6229642 YP_001853602.1 CDS MMAR_5343 NC_010612.1 6454626 6454940 R involved in transcriptional mechanism; transcriptional regulator complement(6454626..6454940) Mycobacterium marinum M 6229643 YP_001853603.1 CDS MMAR_5344 NC_010612.1 6455114 6457654 D PE-PGRS family protein 6455114..6457654 Mycobacterium marinum M 6229644 YP_001853604.1 CDS MMAR_5345 NC_010612.1 6457684 6458472 R hypothetical protein complement(6457684..6458472) Mycobacterium marinum M 6229645 YP_001853605.1 CDS rmlB_1 NC_010612.1 6458741 6459727 D involved in dTDP-L-rhamnose biosynthesis [catalytic activity: dTDP-glucose = DTDP-4-dehydro-6-deoxy-D-glucose + H(2)O]; dTDP-glucose-4,6-dehydratase, RmlB 6458741..6459727 Mycobacterium marinum M 6229646 YP_001853606.1 CDS MMAR_5347 NC_010612.1 6459738 6460964 R function unknown; domain homology to metallopeptidases; hypothetical protein complement(6459738..6460964) Mycobacterium marinum M 6229647 YP_001853607.1 CDS MMAR_5348 NC_010612.1 6461021 6461251 D hypothetical protein 6461021..6461251 Mycobacterium marinum M 6229648 YP_001853608.1 CDS MMAR_5349 NC_010612.1 6461284 6462417 D hypothetical protein 6461284..6462417 Mycobacterium marinum M 6229649 YP_001853609.1 CDS MMAR_5350 NC_010612.1 6462612 6463097 D Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 6462612..6463097 Mycobacterium marinum M 6229650 YP_001853610.1 CDS MMAR_5351 NC_010612.1 6463157 6463597 D hypothetical protein 6463157..6463597 Mycobacterium marinum M 6229651 YP_001853611.1 CDS MMAR_5352 NC_010612.1 6463697 6465088 D function unknown, probably involved in cellular metabolism; oxidoreductase 6463697..6465088 Mycobacterium marinum M 6229652 YP_001853612.1 CDS MMAR_5353 NC_010612.1 6465089 6465853 D function unknown, supposed involved in cellular metabolism; short chain dehydrogenase 6465089..6465853 Mycobacterium marinum M 6229653 YP_001853613.1 CDS MMAR_5354 NC_010612.1 6465856 6467820 D hypothetical protein 6465856..6467820 Mycobacterium marinum M 6229654 YP_001853614.1 CDS embC NC_010612.1 6467820 6471092 D involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbC 6467820..6471092 Mycobacterium marinum M 6229655 YP_001853615.1 CDS embA NC_010612.1 6471302 6474643 D involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbA 6471302..6474643 Mycobacterium marinum M 6229656 YP_001853616.1 CDS embB NC_010612.1 6474640 6477867 D involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbB 6474640..6477867 Mycobacterium marinum M 6229657 YP_001853617.1 CDS MMAR_5358 NC_010612.1 6477934 6479079 D hypothetical protein 6477934..6479079 Mycobacterium marinum M 6229658 YP_001853618.1 CDS MMAR_5359 NC_010612.1 6479252 6479770 D hypothetical protein 6479252..6479770 Mycobacterium marinum M 6229659 YP_001853619.1 CDS MMAR_5360 NC_010612.1 6479913 6480380 D hypothetical protein 6479913..6480380 Mycobacterium marinum M 6229660 YP_001853620.1 CDS fadE35 NC_010612.1 6480433 6482229 D function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE35 6480433..6482229 Mycobacterium marinum M 6229661 YP_001853621.1 CDS MMAR_5362 NC_010612.1 6482363 6488368 D PE-PGRS family protein 6482363..6488368 Mycobacterium marinum M 6229662 YP_001853622.1 CDS accD4_1 NC_010612.1 6488396 6489976 R key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.]; propionyl-CoA carboxylase beta chain 4 AccD4 complement(6488396..6489976) Mycobacterium marinum M 6229663 YP_001853623.1 CDS pks13 NC_010612.1 6489976 6495333 R the enzyme responsible for the final condensation step in mycolic acid biosynthesis, bringing the short and long (mero) chains together; polyketide synthase Pks13 complement(6489976..6495333) Mycobacterium marinum M 6229664 YP_001853624.1 CDS fadD32 NC_010612.1 6495356 6497245 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(6495356..6497245) Mycobacterium marinum M 6229665 YP_001853625.1 CDS MMAR_5366 NC_010612.1 6497562 6498575 R hypothetical protein complement(6497562..6498575) Mycobacterium marinum M 6229666 YP_001853626.1 CDS fbpD NC_010612.1 6498812 6499717 R involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted Mpt51/Mpb51 antigen protein FbpD complement(6498812..6499717) Mycobacterium marinum M 6229667 YP_001853627.1 CDS fbpA NC_010612.1 6499893 6500906 R involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted antigen 85-A FbpA complement(6499893..6500906) Mycobacterium marinum M 6229668 YP_001853628.1 CDS MMAR_5369 NC_010612.1 6501303 6503222 R transmembrane protein complement(6501303..6503222) Mycobacterium marinum M 6229669 YP_001853629.1 CDS MMAR_5370 NC_010612.1 6503269 6504177 R catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase complement(6503269..6504177) Mycobacterium marinum M 6229670 YP_001853630.1 CDS MMAR_5371 NC_010612.1 6504174 6504719 R transmembrane protein complement(6504174..6504719) Mycobacterium marinum M 6229671 YP_001853631.1 CDS glfT NC_010612.1 6504712 6506610 R converts UDP-galactofuranose in cell wall galactan polymerization. has UDP-GalF:beta-D-(1->5) and UDP- GalF:beta-D-(1->6) galactofuranosyltransferase activities; bifunctional UDP-galactofuranosyl transferase GlfT complement(6504712..6506610) Mycobacterium marinum M 6229672 YP_001853632.1 CDS glf NC_010612.1 6506607 6507815 R involved in lipopolysaccharide biosynthesis, in the conversion of UDP-galactopyranose into UDP-galactofuranose through a 2-keto intermediate [catalytic activity: UDP-D- galactopyranose = UDP-D-galacto-1,4-furanose]; UDP-galactopyranose mutase Glf complement(6506607..6507815) Mycobacterium marinum M 6229673 YP_001853633.1 CDS erp NC_010612.1 6508140 6509033 D surface-exposed protein required for multiplication and intracellular growth. seems to play a role in virulence; exported repetitive protein Erp 6508140..6509033 Mycobacterium marinum M 6229674 YP_001853634.1 CDS MMAR_5375 NC_010612.1 6509207 6510859 D hypothetical protein 6509207..6510859 Mycobacterium marinum M 6229675 YP_001853635.1 CDS MMAR_5376 NC_010612.1 6510875 6511648 R hypothetical protein complement(6510875..6511648) Mycobacterium marinum M 6229676 YP_001853636.1 CDS MMAR_5377 NC_010612.1 6511699 6512484 R function unknown, probably involved in cellular metabolism; acyltransferase complement(6511699..6512484) Mycobacterium marinum M 6229677 YP_001853637.1 CDS MMAR_5378 NC_010612.1 6512518 6513273 R function unknown, probably involved in cellular metabolism; acyltransferase complement(6512518..6513273) Mycobacterium marinum M 6229678 YP_001853638.1 CDS MMAR_5379 NC_010612.1 6513277 6514056 R function unknown, probably involved in cellular metabolism; acyltransferase complement(6513277..6514056) Mycobacterium marinum M 6229679 YP_001853639.1 CDS MMAR_5380 NC_010612.1 6514129 6514863 D function unknown, probably involved in cellular metabolism [catalytic activity: ATP + substrate = ADP + substrate 3'-phosphate]; phosphotransferase 6514129..6514863 Mycobacterium marinum M 6229680 YP_001853640.1 CDS MMAR_5381 NC_010612.1 6514924 6516474 D hypothetical protein 6514924..6516474 Mycobacterium marinum M 6229681 YP_001853641.1 CDS MMAR_5382 NC_010612.1 6516474 6516803 D hypothetical protein 6516474..6516803 Mycobacterium marinum M 6229682 YP_001853642.1 CDS MMAR_5383 NC_010612.1 6516808 6518385 R function unknown, probably involved in cellular metabolism; dehydrogenase complement(6516808..6518385) Mycobacterium marinum M 6229683 YP_001853643.1 CDS MMAR_5384 NC_010612.1 6518436 6519083 R involved in transcriptional mechanism; TetR family transcriptional regulator complement(6518436..6519083) Mycobacterium marinum M 6229684 YP_001853644.1 CDS MMAR_5385 NC_010612.1 6519165 6519647 D hypothetical protein 6519165..6519647 Mycobacterium marinum M 6229685 YP_001853645.1 CDS serS NC_010612.1 6519644 6520903 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(6519644..6520903) Mycobacterium marinum M 6229686 YP_001853646.1 CDS MMAR_5387 NC_010612.1 6521015 6522406 D hypothetical protein 6521015..6522406 Mycobacterium marinum M 6229687 YP_001853647.1 CDS MMAR_5388 NC_010612.1 6522411 6522761 D hypothetical protein 6522411..6522761 Mycobacterium marinum M 6229688 YP_001853648.1 CDS MMAR_5389 NC_010612.1 6523041 6523727 R thought to be involved in glycolisis and perhaps glycogen metabolism [catalytic activity: 3- phosphoglycerate = 2-phosphoglycerate]; phosphoglycerate mutase complement(6523041..6523727) Mycobacterium marinum M 6229689 YP_001853649.1 CDS pheA NC_010612.1 6523724 6524671 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(6523724..6524671) Mycobacterium marinum M 6229690 YP_001853650.1 CDS MMAR_5391 NC_010612.1 6524755 6525567 D hypothetical protein 6524755..6525567 Mycobacterium marinum M 6229691 YP_001853651.1 CDS MMAR_5392 NC_010612.1 6525648 6526877 D supposed involved in transcriptional mechanism; transcriptional regulatory protein 6525648..6526877 Mycobacterium marinum M 6229692 YP_001853652.1 CDS bfrB NC_010612.1 6527025 6527615 D involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited; bacterioferritin BfrB 6527025..6527615 Mycobacterium marinum M 6229693 YP_001853653.1 CDS glpQ1 NC_010612.1 6527612 6528463 R glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate]; glycerophosphoryl diester phosphodiesterase complement(6527612..6528463) Mycobacterium marinum M 6229694 YP_001853654.1 CDS MMAR_5395 NC_010612.1 6528463 6529536 R hypothetical protein complement(6528463..6529536) Mycobacterium marinum M 6229695 YP_001853655.1 CDS MMAR_5547 NC_010612.1 6530003 6530158 D hypothetical protein 6530003..6530158 Mycobacterium marinum M 6229696 YP_001853656.1 CDS sodA NC_010612.1 6530307 6530930 D destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 peroxide radical + 2 H(+) = O(2) + H(2)O(2)]; superoxide dismutase [Fe] SodA 6530307..6530930 Mycobacterium marinum M 6229697 YP_001853657.1 CDS MMAR_5397 NC_010612.1 6531147 6531680 D hypothetical protein 6531147..6531680 Mycobacterium marinum M 6229698 YP_001853658.1 CDS MMAR_5398 NC_010612.1 6531934 6532638 D hypothetical protein 6531934..6532638 Mycobacterium marinum M 6229699 YP_001853659.1 CDS MMAR_5399 NC_010612.1 6533101 6533499 D hypothetical protein 6533101..6533499 Mycobacterium marinum M 6229700 YP_001853660.1 CDS MMAR_5400 NC_010612.1 6533624 6534280 D hypothetical protein 6533624..6534280 Mycobacterium marinum M 6229701 YP_001853661.1 CDS MMAR_5401 NC_010612.1 6534287 6534604 D hypothetical protein 6534287..6534604 Mycobacterium marinum M 6229702 YP_001853662.1 CDS hns NC_010612.1 6534720 6535190 D histone-like protein Hns 6534720..6535190 Mycobacterium marinum M 6229703 YP_001853663.1 CDS menG NC_010612.1 6535194 6535691 D regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 6535194..6535691 Mycobacterium marinum M 6229704 YP_001853664.1 CDS ethA NC_010612.1 6535699 6537168 R activates the pro-drug ethionamide (eth); induced eth sensitivity when overexpressed in mycobacterium tuberculosis; monooxygenase EthA complement(6535699..6537168) Mycobacterium marinum M 6229705 YP_001853665.1 CDS ethR NC_010612.1 6537241 6537891 D regulates negatively the production of EthA. induced eth resistance when overexpressed in mycobacterium tuberculosis; TetR family transcriptional regulator 6537241..6537891 Mycobacterium marinum M 6229706 YP_001853666.1 CDS dinP NC_010612.1 6537923 6539122 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 6537923..6539122 Mycobacterium marinum M 6229707 YP_001853667.1 CDS MMAR_5407 NC_010612.1 6539111 6540118 R hypothetical protein complement(6539111..6540118) Mycobacterium marinum M 6229708 YP_001853668.1 CDS MMAR_5408 NC_010612.1 6540129 6540560 R hypothetical protein complement(6540129..6540560) Mycobacterium marinum M 6229709 YP_001853669.1 CDS MMAR_5548 NC_010612.1 6540761 6541012 D hypothetical protein 6540761..6541012 Mycobacterium marinum M 6229710 YP_001853670.1 CDS mpt64 NC_010612.1 6541224 6541916 D immunogenic protein Mpt64 6541224..6541916 Mycobacterium marinum M 6229711 YP_001853671.1 CDS MMAR_5410 NC_010612.1 6541930 6542850 R hypothetical protein complement(6541930..6542850) Mycobacterium marinum M 6229712 YP_001853672.1 CDS MMAR_5411 NC_010612.1 6543114 6543965 D hypothetical protein 6543114..6543965 Mycobacterium marinum M 6229713 YP_001853673.1 CDS MMAR_5572 NC_010612.1 6544039 6544149 R hypothetical protein complement(6544039..6544149) Mycobacterium marinum M 6229714 YP_001853674.1 CDS gltD NC_010612.1 6544333 6545799 R glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta complement(6544333..6545799) Mycobacterium marinum M 6229715 YP_001853675.1 CDS gltB NC_010612.1 6545792 6550375 R probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]; ferredoxin-dependent glutamate synthase large subunit GltB complement(6545792..6550375) Mycobacterium marinum M 6229716 YP_001853676.1 CDS MMAR_5414 NC_010612.1 6551579 6552724 D hypothetical protein 6551579..6552724 Mycobacterium marinum M 6229717 YP_001853677.1 CDS MMAR_5415 NC_010612.1 6552956 6554209 D hypothetical protein 6552956..6554209 Mycobacterium marinum M 6229718 YP_001853678.1 CDS MMAR_5416 NC_010612.1 6554276 6555361 D hypothetical protein 6554276..6555361 Mycobacterium marinum M 6229719 YP_001853679.1 CDS MMAR_5417 NC_010612.1 6555622 6556719 R PPE family protein complement(6555622..6556719) Mycobacterium marinum M 6229720 YP_001853680.1 CDS MMAR_5418 NC_010612.1 6557106 6558458 D hypothetical protein 6557106..6558458 Mycobacterium marinum M 6229721 YP_001853681.1 CDS MMAR_5419 NC_010612.1 6558455 6558793 D hypothetical protein 6558455..6558793 Mycobacterium marinum M 6229722 YP_001853682.1 CDS MMAR_5420 NC_010612.1 6558824 6559840 D hypothetical protein 6558824..6559840 Mycobacterium marinum M 6229723 YP_001853683.1 CDS MMAR_5421 NC_010612.1 6559935 6561170 D hypothetical protein 6559935..6561170 Mycobacterium marinum M 6229724 YP_001853684.1 CDS MMAR_5422 NC_010612.1 6561268 6562512 D hypothetical protein 6561268..6562512 Mycobacterium marinum M 6229725 YP_001853685.1 CDS MMAR_5423 NC_010612.1 6562512 6563717 D hypothetical protein 6562512..6563717 Mycobacterium marinum M 6229726 YP_001853686.1 CDS MMAR_5424 NC_010612.1 6563707 6564747 D hypothetical protein 6563707..6564747 Mycobacterium marinum M 6229727 YP_001853687.1 CDS MMAR_5425 NC_010612.1 6564751 6565515 D hypothetical protein 6564751..6565515 Mycobacterium marinum M 6229728 YP_001853688.1 CDS MMAR_5426 NC_010612.1 6565895 6566314 R hypothetical protein complement(6565895..6566314) Mycobacterium marinum M 6229729 YP_001853689.1 CDS MMAR_5427 NC_010612.1 6566333 6567325 D hypothetical protein 6566333..6567325 Mycobacterium marinum M 6229730 YP_001853690.1 CDS MMAR_5428 NC_010612.1 6567510 6568499 D hypothetical protein 6567510..6568499 Mycobacterium marinum M 6229731 YP_001853691.1 CDS MMAR_5429 NC_010612.1 6568585 6569742 D hypothetical protein 6568585..6569742 Mycobacterium marinum M 6229732 YP_001853692.1 CDS MMAR_5430 NC_010612.1 6569815 6571008 D hypothetical protein 6569815..6571008 Mycobacterium marinum M 6229733 YP_001853693.1 CDS MMAR_5431 NC_010612.1 6571077 6572282 D hypothetical protein 6571077..6572282 Mycobacterium marinum M 6229734 YP_001853694.1 CDS MMAR_5432 NC_010612.1 6572469 6573005 R hypothetical protein complement(6572469..6573005) Mycobacterium marinum M 6229735 YP_001853695.1 CDS MMAR_5433 NC_010612.1 6573099 6573413 R hypothetical protein complement(6573099..6573413) Mycobacterium marinum M 6229736 YP_001853696.1 CDS MMAR_5434 NC_010612.1 6573465 6573803 R hypothetical protein complement(6573465..6573803) Mycobacterium marinum M 6229737 YP_001853697.1 CDS MMAR_5435 NC_010612.1 6573800 6575146 R hypothetical protein complement(6573800..6575146) Mycobacterium marinum M 6229738 YP_001853698.1 CDS MMAR_5436 NC_010612.1 6575629 6576942 D function unknown; contains SpoJ ATPase domain; hypothetical protein 6575629..6576942 Mycobacterium marinum M 6229739 YP_001853699.1 CDS MMAR_5437 NC_010612.1 6577078 6577365 R hypothetical protein complement(6577078..6577365) Mycobacterium marinum M 6229740 YP_001853700.1 CDS MMAR_5438 NC_010612.1 6577754 6578911 D function unknown; potential regulatory role. contains a FHA domain. the FHA (forkhead-associated) domain is a phosphopeptide binding motif; putative regulatory protein 6577754..6578911 Mycobacterium marinum M 6229741 YP_001853701.1 CDS MMAR_5439 NC_010612.1 6579146 6580402 D hypothetical protein 6579146..6580402 Mycobacterium marinum M 6229742 YP_001853702.1 CDS MMAR_5440 NC_010612.1 6580500 6580811 D hypothetical protein 6580500..6580811 Mycobacterium marinum M 6229743 YP_001853703.1 CDS MMAR_5441 NC_010612.1 6580813 6581652 D hypothetical protein 6580813..6581652 Mycobacterium marinum M 6229744 YP_001853704.1 CDS MMAR_5442 NC_010612.1 6581693 6582250 D hypothetical protein 6581693..6582250 Mycobacterium marinum M 6229745 YP_001853705.1 CDS MMAR_5443 NC_010612.1 6582254 6583975 D function unknown; contains predicted ATPase domain; hypothetical protein 6582254..6583975 Mycobacterium marinum M 6229746 YP_001853706.1 CDS MMAR_5444 NC_010612.1 6583979 6585424 D hypothetical protein 6583979..6585424 Mycobacterium marinum M 6229747 YP_001853707.1 CDS MMAR_5445 NC_010612.1 6585421 6587661 D hypothetical protein 6585421..6587661 Mycobacterium marinum M 6229748 YP_001853708.1 CDS MMAR_5446 NC_010612.1 6587711 6589486 D hypothetical protein 6587711..6589486 Mycobacterium marinum M 6229749 YP_001853709.1 CDS MMAR_5447 NC_010612.1 6589622 6589918 D PE family protein 6589622..6589918 Mycobacterium marinum M 6229750 YP_001853710.1 CDS MMAR_5448 NC_010612.1 6589963 6591066 D PPE family protein 6589963..6591066 Mycobacterium marinum M 6229751 YP_001853711.1 CDS esxB NC_010612.1 6591158 6591460 D function unknown; a component of a novel secretion apparatus. (10 kDa culture filtrate antigen cfp10); Esat-6 like protein EsxB 6591158..6591460 Mycobacterium marinum M 6229752 YP_001853712.1 CDS esxA NC_010612.1 6591497 6591784 D function unknown; probably a component of a novel secretion mechanism. forms a heterodimer with EsxB; 6 kDa early secretory antigenic target EsxA 6591497..6591784 Mycobacterium marinum M 6229753 YP_001853713.1 CDS MMAR_5451 NC_010612.1 6591900 6594539 D function unknown; hypothetical protein 6591900..6594539 Mycobacterium marinum M 6229754 YP_001853714.1 CDS MMAR_5452 NC_010612.1 6594632 6596071 D hypothetical protein 6594632..6596071 Mycobacterium marinum M 6229755 YP_001853715.1 CDS MMAR_5453 NC_010612.1 6596198 6597034 D hypothetical protein 6596198..6597034 Mycobacterium marinum M 6229756 YP_001853716.1 CDS MMAR_5454 NC_010612.1 6597020 6597916 R hypothetical protein complement(6597020..6597916) Mycobacterium marinum M 6229757 YP_001853717.1 CDS MMAR_5455 NC_010612.1 6598333 6600663 R hypothetical protein complement(6598333..6600663) Mycobacterium marinum M 6229758 YP_001853718.1 CDS MMAR_5456 NC_010612.1 6601072 6601419 R hypothetical protein complement(6601072..6601419) Mycobacterium marinum M 6229759 YP_001853719.1 CDS espB NC_010612.1 6601456 6602820 R Required for intracellular persistence; ESX-1 secreted protein, EspB complement(6601456..6602820) Mycobacterium marinum M 6229760 YP_001853720.1 CDS MMAR_5458 NC_010612.1 6602919 6604316 R hypothetical protein complement(6602919..6604316) Mycobacterium marinum M 6229761 YP_001853721.1 CDS mycP3_1 NC_010612.1 6604313 6605719 R thought to have proteolytic activity; membrane-anchored serine protease (mycosin), MycP3 complement(6604313..6605719) Mycobacterium marinum M 6229762 YP_001853722.1 CDS MMAR_5461 NC_010612.1 6606567 6607442 R hypothetical protein complement(6606567..6607442) Mycobacterium marinum M 6229764 YP_001853723.1 CDS MMAR_5462 NC_010612.1 6608091 6608621 R hypothetical protein complement(6608091..6608621) Mycobacterium marinum M 6229765 YP_001853724.1 CDS MMAR_5463 NC_010612.1 6608631 6609239 R hypothetical protein complement(6608631..6609239) Mycobacterium marinum M 6229766 YP_001853725.1 CDS MMAR_5464 NC_010612.1 6609763 6612183 R related to a family of actin-ADP-ribosylating toxins from bacillus and clostridia hence may play a role in virulence or protection against predation; ADP-ribosyltransferse complement(6609763..6612183) Mycobacterium marinum M 6229767 YP_001853726.1 CDS esxE NC_010612.1 6612188 6612478 R EsaT-6 like protein EsxE complement(6612188..6612478) Mycobacterium marinum M 6229768 YP_001853727.1 CDS esxF NC_010612.1 6612471 6612782 R EsaT-6 like protein EsxF complement(6612471..6612782) Mycobacterium marinum M 6229769 YP_001853728.1 CDS lppJ NC_010612.1 6612893 6613381 R lipoprotein LppJ complement(6612893..6613381) Mycobacterium marinum M 6229770 YP_001853729.1 CDS MMAR_5468 NC_010612.1 6613461 6615548 R hypothetical protein complement(6613461..6615548) Mycobacterium marinum M 6229771 YP_001853730.1 CDS MMAR_5469 NC_010612.1 6615844 6616158 R hypothetical protein complement(6615844..6616158) Mycobacterium marinum M 6229772 YP_001853731.1 CDS MMAR_5470 NC_010612.1 6616290 6616799 R hypothetical protein complement(6616290..6616799) Mycobacterium marinum M 6229773 YP_001853732.1 CDS pcnA NC_010612.1 6616824 6618269 R involved in transcription mechanism [catalytic activity: N ATP + (nucleotide)(M) = N diphosphate + (nucleotide)(M+N)]; poly(a) polymerase PcnA complement(6616824..6618269) Mycobacterium marinum M 6229774 YP_001853733.1 CDS MMAR_5472 NC_010612.1 6618435 6619181 D hypothetical protein 6618435..6619181 Mycobacterium marinum M 6229775 YP_001853734.1 CDS MMAR_5473 NC_010612.1 6619178 6621559 D hypothetical protein 6619178..6621559 Mycobacterium marinum M 6229776 YP_001853735.1 CDS MMAR_5474 NC_010612.1 6621676 6625218 D transmembrane protein 6621676..6625218 Mycobacterium marinum M 6229777 YP_001853736.1 CDS sigM NC_010612.1 6625280 6625867 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 6625280..6625867 Mycobacterium marinum M 6229778 YP_001853737.1 CDS MMAR_5476 NC_010612.1 6625943 6626692 D hypothetical protein 6625943..6626692 Mycobacterium marinum M 6229779 YP_001853738.1 CDS trxB2 NC_010612.1 6626782 6627780 D enzyme that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. seems regulated by SigH. [catalytic activity: NADPH + oxidized thioredoxin = NADP(+) + reduced thioredoxin]; thioredoxin reductase TrxB2 6626782..6627780 Mycobacterium marinum M 6229780 YP_001853739.1 CDS trxC NC_010612.1 6627777 6628130 D thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions. forms together with thioredoxin reductase and NADPH a redox active system which donates electrons to a wide variety of different metabolic process (by similarity). seems regulated by SigH; thioredoxin TrxC 6627777..6628130 Mycobacterium marinum M 6229781 YP_001853740.1 CDS MMAR_5479 NC_010612.1 6628262 6629482 D function unknown, probably involved in cellular metabolism; hydrolase 6628262..6629482 Mycobacterium marinum M 6229782 YP_001853741.1 CDS MMAR_5480 NC_010612.1 6629521 6630252 R hypothetical protein complement(6629521..6630252) Mycobacterium marinum M 6229783 YP_001853742.1 CDS parB NC_010612.1 6630723 6631706 R involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication. binds to the DNA origin of replication (by similarity); chromosome partitioning protein ParB complement(6630723..6631706) Mycobacterium marinum M 6229784 YP_001853743.1 CDS parA NC_010612.1 6631703 6632836 R involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication (by similarity); chromosome partitioning protein ParA complement(6631703..6632836) Mycobacterium marinum M 6229785 YP_001853744.1 CDS gidB NC_010612.1 6632833 6633519 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(6632833..6633519) Mycobacterium marinum M 6229786 YP_001853745.1 CDS MMAR_5484 NC_010612.1 6633672 6634220 R function unknown, domain identity suggests it is a JAG RNA-binding protein; hypothetical protein complement(6633672..6634220) Mycobacterium marinum M 6229787 YP_001853746.1 CDS MMAR_5485 NC_010612.1 6634333 6635448 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC complement(6634333..6635448) Mycobacterium marinum M 6229788 YP_001853747.1 CDS MMAR_5578 NC_010612.1 6635432 6635740 R hypothetical protein complement(6635432..6635740) Mycobacterium marinum M 6229789 YP_001853748.1 CDS rnpA NC_010612.1 6635767 6636129 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(6635767..6636129) Mycobacterium marinum M 6229790 YP_001853749.1 CDS rpmH NC_010612.1 6636153 6636296 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(6636153..6636296) Mycobacterium marinum M 6229791 MMAR_5487 tRNA ileT NC_010612.1 10914 10990 D tRNA-Ile 10914..10990 Mycobacterium marinum M 6224532 MMAR_5488 tRNA alaT NC_010612.1 11151 11226 D tRNA-Ala 11151..11226 Mycobacterium marinum M 6224533 MMAR_5489 tRNA leuT NC_010612.1 26889 26971 D tRNA-Leu 26889..26971 Mycobacterium marinum M 6224549 MMAR_5490 tRNA glyU NC_010612.1 695967 696040 R tRNA-Gly complement(695967..696040) Mycobacterium marinum M 6224844 MMAR_5491 tRNA tyrT NC_010612.1 1117053 1117138 D tRNA-Tyr 1117053..1117138 Mycobacterium marinum M 6225169 MMAR_5492 tRNA thrT NC_010612.1 1181162 1181234 D tRNA-Thr 1181162..1181234 Mycobacterium marinum M 6225216 MMAR_5493 tRNA metT NC_010612.1 1181287 1181363 D tRNA-Met 1181287..1181363 Mycobacterium marinum M 6225217 MMAR_5494 tRNA trpT NC_010612.1 1183179 1183251 D tRNA-Trp 1183179..1183251 Mycobacterium marinum M 6225222 MMAR_5495 tRNA metU NC_010612.1 1670070 1670146 D tRNA-Phe 1670070..1670146 Mycobacterium marinum M 6225629 MMAR_5497 tRNA alaU NC_010612.1 1912756 1912828 D tRNA-Ala 1912756..1912828 Mycobacterium marinum M 6225849 MMAR_5498 tRNA glnU NC_010612.1 2070591 2070665 D tRNA-Gln 2070591..2070665 Mycobacterium marinum M 6225977 MMAR_5499 tRNA gluU NC_010612.1 2070735 2070810 D tRNA-Glu 2070735..2070810 Mycobacterium marinum M 6225978 MMAR_5500 tRNA valU NC_010612.1 2475171 2475245 R tRNA-Val complement(2475171..2475245) Mycobacterium marinum M 6226314 MMAR_5501 tRNA cysU NC_010612.1 2475261 2475334 R tRNA-Cys complement(2475261..2475334) Mycobacterium marinum M 6226315 MMAR_5502 tRNA glyT NC_010612.1 2475361 2475436 R tRNA-Gly complement(2475361..2475436) Mycobacterium marinum M 6226316 MMAR_5503 tRNA valT NC_010612.1 2475607 2475681 D tRNA-Val 2475607..2475681 Mycobacterium marinum M 6226317 MMAR_5504 tRNA leuV NC_010612.1 2931168 2931244 R tRNA-Leu complement(2931168..2931244) Mycobacterium marinum M 6226694 MMAR_5505 tRNA proT NC_010612.1 3082783 3082856 D tRNA-Pro 3082783..3082856 Mycobacterium marinum M 6226796 MMAR_5506 tRNA leuU NC_010612.1 3807972 3808057 D tRNA-Leu 3807972..3808057 Mycobacterium marinum M 6227390 MMAR_5508 tRNA valV NC_010612.1 4111792 4111866 R tRNA-Val complement(4111792..4111866) Mycobacterium marinum M 6227600 MMAR_5509 tRNA metT_1 NC_010612.1 4430819 4430892 R tRNA-Met complement(4430819..4430892) Mycobacterium marinum M 6227877 MMAR_5510 tRNA asnT NC_010612.1 4494467 4494542 R tRNA-Asn complement(4494467..4494542) Mycobacterium marinum M 6227921 MMAR_5511 tRNA proU NC_010612.1 4732730 4732806 R tRNA-Pro complement(4732730..4732806) Mycobacterium marinum M 6228082 MMAR_5512 tRNA glyV NC_010612.1 4732971 4733044 D tRNA-Gly 4732971..4733044 Mycobacterium marinum M 6228083 MMAR_5513 tRNA argW NC_010612.1 4771830 4771906 D tRNA-Arg 4771830..4771906 Mycobacterium marinum M 6228111 MMAR_5514 tRNA hisT NC_010612.1 4798472 4798547 D tRNA-His 4798472..4798547 Mycobacterium marinum M 6228136 MMAR_5515 tRNA lysU NC_010612.1 4812260 4812332 D tRNA-Lys 4812260..4812332 Mycobacterium marinum M 6228151 MMAR_5516 tRNA leuW NC_010612.1 4980479 4980565 R tRNA-Leu complement(4980479..4980565) Mycobacterium marinum M 6228313 MMAR_5520 tRNA argV NC_010612.1 5059608 5059683 D tRNA-Arg 5059608..5059683 Mycobacterium marinum M 6228385 MMAR_5522 tRNA leuX NC_010612.1 5470769 5470845 R tRNA-Leu complement(5470769..5470845) Mycobacterium marinum M 6228733 MMAR_5523 tRNA glnT NC_010612.1 5488244 5488315 D tRNA-Gln 5488244..5488315 Mycobacterium marinum M 6228750 MMAR_5524 tRNA alaV NC_010612.1 5547215 5547287 R tRNA-Ala complement(5547215..5547287) Mycobacterium marinum M 6228802 MMAR_5525 tRNA argT NC_010612.1 5628641 5628716 D tRNA-Arg 5628641..5628716 Mycobacterium marinum M 6228872 MMAR_5526 tRNA pheU NC_010612.1 5904289 5904365 R tRNA-Phe complement(5904289..5904365) Mycobacterium marinum M 6229135 MMAR_5527 tRNA aspT NC_010612.1 5904393 5904469 R tRNA-Asp complement(5904393..5904469) Mycobacterium marinum M 6229136 MMAR_5528 tRNA gluT NC_010612.1 5904507 5904579 R tRNA-Glu complement(5904507..5904579) Mycobacterium marinum M 6229137 MMAR_5529 tRNA lysT NC_010612.1 5904703 5904775 D tRNA-Lys 5904703..5904775 Mycobacterium marinum M 6229138 MMAR_5530 tRNA thrV NC_010612.1 6002725 6002799 D tRNA-Thr 6002725..6002799 Mycobacterium marinum M 6229234 MMAR_5531 tRNA thrU NC_010612.1 6216221 6216293 R tRNA-Thr complement(6216221..6216293) Mycobacterium marinum M 6229427 MMAR_5532 tRNA proY NC_010612.1 6258100 6258173 D tRNA-Pro 6258100..6258173 Mycobacterium marinum M 6229468 MMAR_5533 tRNA selC NC_010612.1 6270689 6270779 D tRNA-Sec 6270689..6270779 Mycobacterium marinum M 6229484 MMAR_5534 tRNA serV NC_010612.1 6331265 6331353 D tRNA-Ser 6331265..6331353 Mycobacterium marinum M 6229537 MMAR_5535 tRNA serX NC_010612.1 6396151 6396240 R tRNA-Ser complement(6396151..6396240) Mycobacterium marinum M 6229590 MMAR_5536 tRNA argU NC_010612.1 6432557 6432629 R tRNA-Arg complement(6432557..6432629) Mycobacterium marinum M 6229622 MMAR_5537 tRNA serT NC_010612.1 6432662 6432750 R tRNA-Ser complement(6432662..6432750) Mycobacterium marinum M 6229623 MMAR_5538 tRNA serU NC_010612.1 6439750 6439839 R tRNA-Ser complement(6439750..6439839) Mycobacterium marinum M 6229630 MMAR_5517 rRNA rrf NC_010612.1 5030337 5030452 R 5S ribosomal RNA complement(5030337..5030452) Mycobacterium marinum M 6228359 MMAR_5518 rRNA rrl NC_010612.1 5030539 5033648 R 23S ribosomal RNA complement(join(5030539..5032102,5032052..5033648)) Mycobacterium marinum M 6228360 MMAR_5519 rRNA rrs NC_010612.1 5033921 5035459 R 16S ribosomal RNA complement(5033921..5035459) Mycobacterium marinum M 6228361