-- dump date 20140619_145655 -- class Genbank::misc_feature -- table misc_feature_note -- id note 465515000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 465515000003 Walker A motif; other site 465515000004 ATP binding site [chemical binding]; other site 465515000005 Walker B motif; other site 465515000006 arginine finger; other site 465515000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 465515000008 DnaA box-binding interface [nucleotide binding]; other site 465515000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 465515000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 465515000011 putative DNA binding surface [nucleotide binding]; other site 465515000012 dimer interface [polypeptide binding]; other site 465515000013 beta-clamp/clamp loader binding surface; other site 465515000014 beta-clamp/translesion DNA polymerase binding surface; other site 465515000015 recombination protein F; Reviewed; Region: recF; PRK00064 465515000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 465515000017 Walker A/P-loop; other site 465515000018 ATP binding site [chemical binding]; other site 465515000019 Q-loop/lid; other site 465515000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515000021 ABC transporter signature motif; other site 465515000022 Walker B; other site 465515000023 D-loop; other site 465515000024 H-loop/switch region; other site 465515000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 465515000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 465515000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 465515000028 anchoring element; other site 465515000029 dimer interface [polypeptide binding]; other site 465515000030 ATP binding site [chemical binding]; other site 465515000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 465515000032 active site 465515000033 putative metal-binding site [ion binding]; other site 465515000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 465515000035 DNA gyrase subunit A; Validated; Region: PRK05560 465515000036 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 465515000037 CAP-like domain; other site 465515000038 active site 465515000039 primary dimer interface [polypeptide binding]; other site 465515000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465515000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465515000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465515000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465515000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465515000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465515000046 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 465515000047 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 465515000048 dimer interface [polypeptide binding]; other site 465515000049 ssDNA binding site [nucleotide binding]; other site 465515000050 tetramer (dimer of dimers) interface [polypeptide binding]; other site 465515000051 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 465515000052 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 465515000053 AAA-like domain; Region: AAA_10; pfam12846 465515000054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515000055 Methyltransferase domain; Region: Methyltransf_31; pfam13847 465515000056 S-adenosylmethionine binding site [chemical binding]; other site 465515000057 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 465515000058 Peptidase family M23; Region: Peptidase_M23; pfam01551 465515000059 ParB-like nuclease domain; Region: ParB; smart00470 465515000060 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 465515000061 Helix-turn-helix domain; Region: HTH_38; pfam13936 465515000062 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 465515000063 polymerase nucleotide-binding site; other site 465515000064 DNA-binding residues [nucleotide binding]; DNA binding site 465515000065 nucleotide binding site [chemical binding]; other site 465515000066 primase nucleotide-binding site [nucleotide binding]; other site 465515000067 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 465515000068 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515000069 MULE transposase domain; Region: MULE; pfam10551 465515000070 Domain of unknown function (DUF955); Region: DUF955; pfam06114 465515000071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465515000072 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 465515000073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465515000074 hypothetical protein; Provisional; Region: PRK06185 465515000075 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 465515000076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465515000077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515000078 TrwC relaxase; Region: TrwC; pfam08751 465515000079 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 465515000080 AAA domain; Region: AAA_30; pfam13604 465515000081 AAA domain; Region: AAA_22; pfam13401 465515000082 Family description; Region: UvrD_C_2; pfam13538 465515000083 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515000084 MULE transposase domain; Region: MULE; pfam10551 465515000085 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515000086 MULE transposase domain; Region: MULE; pfam10551 465515000087 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 465515000088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515000089 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515000090 Helix-turn-helix domain; Region: HTH_38; pfam13936 465515000091 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 465515000092 Helix-turn-helix domain; Region: HTH_38; pfam13936 465515000093 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 465515000094 Integrase core domain; Region: rve; pfam00665 465515000095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515000096 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515000097 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 465515000098 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 465515000099 nucleotide binding site [chemical binding]; other site 465515000100 NEF interaction site [polypeptide binding]; other site 465515000101 SBD interface [polypeptide binding]; other site 465515000102 GrpE; Region: GrpE; pfam01025 465515000103 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 465515000104 dimer interface [polypeptide binding]; other site 465515000105 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 465515000106 chaperone protein DnaJ; Provisional; Region: PRK14299 465515000107 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 465515000108 HSP70 interaction site [polypeptide binding]; other site 465515000109 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 465515000110 substrate binding site [polypeptide binding]; other site 465515000111 dimer interface [polypeptide binding]; other site 465515000112 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 465515000113 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 465515000114 DNA binding residues [nucleotide binding] 465515000115 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 465515000116 Clp amino terminal domain; Region: Clp_N; pfam02861 465515000117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515000118 Walker A motif; other site 465515000119 ATP binding site [chemical binding]; other site 465515000120 Walker B motif; other site 465515000121 arginine finger; other site 465515000122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515000123 Walker A motif; other site 465515000124 ATP binding site [chemical binding]; other site 465515000125 Walker B motif; other site 465515000126 arginine finger; other site 465515000127 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 465515000128 thioredoxin 2; Provisional; Region: PRK10996 465515000129 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 465515000130 catalytic residues [active] 465515000131 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 465515000132 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 465515000133 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 465515000134 ligand binding site [chemical binding]; other site 465515000135 flexible hinge region; other site 465515000136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515000137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515000138 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 465515000139 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 465515000140 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 465515000141 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 465515000142 active site 465515000143 Rhomboid family; Region: Rhomboid; pfam01694 465515000144 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 465515000145 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 465515000146 Glutamine amidotransferase class-I; Region: GATase; pfam00117 465515000147 glutamine binding [chemical binding]; other site 465515000148 catalytic triad [active] 465515000149 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 465515000150 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 465515000151 active site 465515000152 ATP binding site [chemical binding]; other site 465515000153 substrate binding site [chemical binding]; other site 465515000154 activation loop (A-loop); other site 465515000155 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 465515000156 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 465515000157 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 465515000158 Catalytic domain of Protein Kinases; Region: PKc; cd00180 465515000159 active site 465515000160 ATP binding site [chemical binding]; other site 465515000161 substrate binding site [chemical binding]; other site 465515000162 activation loop (A-loop); other site 465515000163 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 465515000164 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 465515000165 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 465515000166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 465515000167 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 465515000168 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 465515000169 active site 465515000170 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 465515000171 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 465515000172 phosphopeptide binding site; other site 465515000173 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 465515000174 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 465515000175 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 465515000176 phosphopeptide binding site; other site 465515000177 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 465515000178 Ligand Binding Site [chemical binding]; other site 465515000179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 465515000180 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 465515000181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 465515000182 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 465515000183 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 465515000184 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 465515000185 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 465515000186 NAD(P) binding site [chemical binding]; other site 465515000187 Uncharacterized conserved protein [Function unknown]; Region: COG2353 465515000188 Dienelactone hydrolase family; Region: DLH; pfam01738 465515000189 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 465515000190 hypothetical protein; Provisional; Region: PRK06062 465515000191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465515000192 inhibitor-cofactor binding pocket; inhibition site 465515000193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515000194 catalytic residue [active] 465515000195 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 465515000196 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 465515000197 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 465515000198 putative substrate binding site [chemical binding]; other site 465515000199 putative ATP binding site [chemical binding]; other site 465515000200 malate dehydrogenase; Provisional; Region: PRK05442 465515000201 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 465515000202 NAD(P) binding site [chemical binding]; other site 465515000203 LDH/MDH dimer interface [polypeptide binding]; other site 465515000204 substrate binding site [chemical binding]; other site 465515000205 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 465515000206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515000207 active site 465515000208 motif I; other site 465515000209 motif II; other site 465515000210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 465515000211 LabA_like proteins; Region: LabA_like; cd06167 465515000212 putative metal binding site [ion binding]; other site 465515000213 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 465515000214 lysine transporter; Provisional; Region: PRK10836 465515000215 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 465515000216 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 465515000217 tetramer interface [polypeptide binding]; other site 465515000218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515000219 catalytic residue [active] 465515000220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515000221 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465515000222 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 465515000223 putative DNA binding site [nucleotide binding]; other site 465515000224 putative Zn2+ binding site [ion binding]; other site 465515000225 AsnC family; Region: AsnC_trans_reg; pfam01037 465515000226 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 465515000227 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 465515000228 putative active site [active] 465515000229 catalytic site [active] 465515000230 putative metal binding site [ion binding]; other site 465515000231 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 465515000232 NAD(P) binding site [chemical binding]; other site 465515000233 catalytic residues [active] 465515000234 phosphoglucomutase; Validated; Region: PRK07564 465515000235 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 465515000236 active site 465515000237 substrate binding site [chemical binding]; other site 465515000238 metal binding site [ion binding]; metal-binding site 465515000239 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 465515000240 metal binding site 2 [ion binding]; metal-binding site 465515000241 putative DNA binding helix; other site 465515000242 metal binding site 1 [ion binding]; metal-binding site 465515000243 dimer interface [polypeptide binding]; other site 465515000244 structural Zn2+ binding site [ion binding]; other site 465515000245 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515000246 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 465515000247 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 465515000248 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 465515000249 Amidase; Region: Amidase; cl11426 465515000250 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 465515000251 active site residue [active] 465515000252 prephenate dehydratase; Provisional; Region: PRK11898 465515000253 Prephenate dehydratase; Region: PDT; pfam00800 465515000254 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 465515000255 putative L-Phe binding site [chemical binding]; other site 465515000256 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 465515000257 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 465515000258 seryl-tRNA synthetase; Provisional; Region: PRK05431 465515000259 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 465515000260 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 465515000261 dimer interface [polypeptide binding]; other site 465515000262 active site 465515000263 motif 1; other site 465515000264 motif 2; other site 465515000265 motif 3; other site 465515000266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515000267 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 465515000268 active site 465515000269 motif I; other site 465515000270 motif II; other site 465515000271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515000272 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 465515000273 dimer interface [polypeptide binding]; other site 465515000274 substrate binding site [chemical binding]; other site 465515000275 metal binding sites [ion binding]; metal-binding site 465515000276 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 465515000277 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 465515000278 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 465515000279 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 465515000280 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 465515000281 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 465515000282 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 465515000283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465515000284 active site 465515000285 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 465515000286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515000287 Walker A motif; other site 465515000288 ATP binding site [chemical binding]; other site 465515000289 Walker B motif; other site 465515000290 arginine finger; other site 465515000291 Peptidase family M41; Region: Peptidase_M41; pfam01434 465515000292 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 465515000293 homodecamer interface [polypeptide binding]; other site 465515000294 GTP cyclohydrolase I; Provisional; Region: PLN03044 465515000295 active site 465515000296 putative catalytic site residues [active] 465515000297 zinc binding site [ion binding]; other site 465515000298 GTP-CH-I/GFRP interaction surface; other site 465515000299 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 465515000300 substrate binding pocket [chemical binding]; other site 465515000301 inhibitor binding site; inhibition site 465515000302 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 465515000303 homooctamer interface [polypeptide binding]; other site 465515000304 active site 465515000305 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 465515000306 catalytic center binding site [active] 465515000307 ATP binding site [chemical binding]; other site 465515000308 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 465515000309 Bacterial PH domain; Region: DUF304; cl01348 465515000310 Predicted membrane protein [Function unknown]; Region: COG3428 465515000311 Bacterial PH domain; Region: DUF304; pfam03703 465515000312 Bacterial PH domain; Region: DUF304; pfam03703 465515000313 Bacterial PH domain; Region: DUF304; pfam03703 465515000314 Rossmann-like domain; Region: Rossmann-like; pfam10727 465515000315 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 465515000316 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 465515000317 Low molecular weight phosphatase family; Region: LMWPc; cd00115 465515000318 active site 465515000319 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 465515000320 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 465515000321 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 465515000322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465515000323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465515000324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465515000325 dimerization interface [polypeptide binding]; other site 465515000326 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 465515000327 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 465515000328 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 465515000329 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 465515000330 tetrameric interface [polypeptide binding]; other site 465515000331 NAD binding site [chemical binding]; other site 465515000332 catalytic residues [active] 465515000333 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 465515000334 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 465515000335 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 465515000336 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 465515000337 active site 465515000338 catalytic site [active] 465515000339 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 465515000340 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 465515000341 active site 465515000342 nucleotide binding site [chemical binding]; other site 465515000343 HIGH motif; other site 465515000344 KMSKS motif; other site 465515000345 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 465515000346 active site 465515000347 DNA binding site [nucleotide binding] 465515000348 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 465515000349 putative hydrophobic ligand binding site [chemical binding]; other site 465515000350 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 465515000351 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 465515000352 active site 465515000353 Zn binding site [ion binding]; other site 465515000354 MarR family; Region: MarR; pfam01047 465515000355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515000356 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465515000357 putative substrate translocation pore; other site 465515000358 glyoxylate reductase; Reviewed; Region: PRK13243 465515000359 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 465515000360 dimerization interface [polypeptide binding]; other site 465515000361 ligand binding site [chemical binding]; other site 465515000362 NADP binding site [chemical binding]; other site 465515000363 catalytic site [active] 465515000364 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 465515000365 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 465515000366 dimer interface [polypeptide binding]; other site 465515000367 putative anticodon binding site; other site 465515000368 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 465515000369 motif 1; other site 465515000370 dimer interface [polypeptide binding]; other site 465515000371 active site 465515000372 motif 2; other site 465515000373 motif 3; other site 465515000374 Lsr2; Region: Lsr2; pfam11774 465515000375 Clp protease ATP binding subunit; Region: clpC; CHL00095 465515000376 Clp amino terminal domain; Region: Clp_N; pfam02861 465515000377 Clp amino terminal domain; Region: Clp_N; pfam02861 465515000378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515000379 Walker A motif; other site 465515000380 ATP binding site [chemical binding]; other site 465515000381 Walker B motif; other site 465515000382 arginine finger; other site 465515000383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515000384 Walker A motif; other site 465515000385 ATP binding site [chemical binding]; other site 465515000386 Walker B motif; other site 465515000387 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 465515000388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465515000389 Coenzyme A binding pocket [chemical binding]; other site 465515000390 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 465515000391 endonuclease III; Region: ENDO3c; smart00478 465515000392 minor groove reading motif; other site 465515000393 helix-hairpin-helix signature motif; other site 465515000394 substrate binding pocket [chemical binding]; other site 465515000395 active site 465515000396 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 465515000397 DNA repair protein RadA; Provisional; Region: PRK11823 465515000398 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465515000399 Walker A motif; other site 465515000400 ATP binding site [chemical binding]; other site 465515000401 Walker B motif; other site 465515000402 Predicted membrane protein [Function unknown]; Region: COG4129 465515000403 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 465515000404 PBP superfamily domain; Region: PBP_like_2; cl17296 465515000405 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 465515000406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515000407 dimer interface [polypeptide binding]; other site 465515000408 conserved gate region; other site 465515000409 putative PBP binding loops; other site 465515000410 ABC-ATPase subunit interface; other site 465515000411 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 465515000412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515000413 dimer interface [polypeptide binding]; other site 465515000414 conserved gate region; other site 465515000415 putative PBP binding loops; other site 465515000416 ABC-ATPase subunit interface; other site 465515000417 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 465515000418 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 465515000419 Walker A/P-loop; other site 465515000420 ATP binding site [chemical binding]; other site 465515000421 Q-loop/lid; other site 465515000422 ABC transporter signature motif; other site 465515000423 Walker B; other site 465515000424 D-loop; other site 465515000425 H-loop/switch region; other site 465515000426 Phosphate transporter family; Region: PHO4; pfam01384 465515000427 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 465515000428 Serine hydrolase (FSH1); Region: FSH1; pfam03959 465515000429 Protein of unknown function (DUF445); Region: DUF445; pfam04286 465515000430 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 465515000431 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 465515000432 active site 465515000433 catalytic site [active] 465515000434 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 465515000435 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 465515000436 peptide binding site [polypeptide binding]; other site 465515000437 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 465515000438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515000439 putative PBP binding loops; other site 465515000440 dimer interface [polypeptide binding]; other site 465515000441 ABC-ATPase subunit interface; other site 465515000442 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 465515000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515000444 dimer interface [polypeptide binding]; other site 465515000445 conserved gate region; other site 465515000446 putative PBP binding loops; other site 465515000447 ABC-ATPase subunit interface; other site 465515000448 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 465515000449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465515000450 Walker A/P-loop; other site 465515000451 ATP binding site [chemical binding]; other site 465515000452 Q-loop/lid; other site 465515000453 ABC transporter signature motif; other site 465515000454 Walker B; other site 465515000455 D-loop; other site 465515000456 H-loop/switch region; other site 465515000457 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465515000458 Walker A/P-loop; other site 465515000459 ATP binding site [chemical binding]; other site 465515000460 Q-loop/lid; other site 465515000461 ABC transporter signature motif; other site 465515000462 Walker B; other site 465515000463 D-loop; other site 465515000464 H-loop/switch region; other site 465515000465 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 465515000466 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 465515000467 propionate/acetate kinase; Provisional; Region: PRK12379 465515000468 phosphate acetyltransferase; Reviewed; Region: PRK05632 465515000469 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 465515000470 DRTGG domain; Region: DRTGG; pfam07085 465515000471 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 465515000472 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 465515000473 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 465515000474 Domain of unknown function DUF77; Region: DUF77; pfam01910 465515000475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 465515000476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465515000477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 465515000478 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 465515000479 Ligand Binding Site [chemical binding]; other site 465515000480 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 465515000481 Ligand Binding Site [chemical binding]; other site 465515000482 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 465515000483 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 465515000484 catalytic triad [active] 465515000485 conserved cis-peptide bond; other site 465515000486 BCCT family transporter; Region: BCCT; pfam02028 465515000487 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 465515000488 Spore germination protein; Region: Spore_permease; cl17796 465515000489 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 465515000490 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 465515000491 active site 465515000492 catalytic site [active] 465515000493 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 465515000494 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 465515000495 putative FMN binding site [chemical binding]; other site 465515000496 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 465515000497 putative catalytic site [active] 465515000498 putative phosphate binding site [ion binding]; other site 465515000499 active site 465515000500 metal binding site A [ion binding]; metal-binding site 465515000501 DNA binding site [nucleotide binding] 465515000502 putative AP binding site [nucleotide binding]; other site 465515000503 putative metal binding site B [ion binding]; other site 465515000504 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 465515000505 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 465515000506 homodimer interface [polypeptide binding]; other site 465515000507 NAD binding pocket [chemical binding]; other site 465515000508 ATP binding pocket [chemical binding]; other site 465515000509 Mg binding site [ion binding]; other site 465515000510 active-site loop [active] 465515000511 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 465515000512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465515000513 active site 465515000514 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 465515000515 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515000516 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515000517 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 465515000518 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 465515000519 oligomer interface [polypeptide binding]; other site 465515000520 metal binding site [ion binding]; metal-binding site 465515000521 metal binding site [ion binding]; metal-binding site 465515000522 putative Cl binding site [ion binding]; other site 465515000523 basic sphincter; other site 465515000524 hydrophobic gate; other site 465515000525 periplasmic entrance; other site 465515000526 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 465515000527 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 465515000528 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 465515000529 Secretory lipase; Region: LIP; pfam03583 465515000530 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 465515000531 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 465515000532 active site 465515000533 intersubunit interface [polypeptide binding]; other site 465515000534 zinc binding site [ion binding]; other site 465515000535 Na+ binding site [ion binding]; other site 465515000536 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 465515000537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465515000538 non-specific DNA binding site [nucleotide binding]; other site 465515000539 salt bridge; other site 465515000540 sequence-specific DNA binding site [nucleotide binding]; other site 465515000541 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 465515000542 Domain of unknown function (DUF955); Region: DUF955; pfam06114 465515000543 isocitrate lyase; Provisional; Region: PRK15063 465515000544 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 465515000545 tetramer interface [polypeptide binding]; other site 465515000546 active site 465515000547 Mg2+/Mn2+ binding site [ion binding]; other site 465515000548 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 465515000549 malate synthase A; Region: malate_syn_A; TIGR01344 465515000550 active site 465515000551 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 465515000552 thymidine kinase; Provisional; Region: PRK04296 465515000553 Helix-turn-helix domain; Region: HTH_17; cl17695 465515000554 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515000555 MULE transposase domain; Region: MULE; pfam10551 465515000556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465515000557 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515000558 biotin synthase; Validated; Region: PRK06256 465515000559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465515000560 FeS/SAM binding site; other site 465515000561 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 465515000562 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 465515000563 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 465515000564 GDP-binding site [chemical binding]; other site 465515000565 ACT binding site; other site 465515000566 IMP binding site; other site 465515000567 hydroperoxidase II; Provisional; Region: katE; PRK11249 465515000568 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 465515000569 heme binding pocket [chemical binding]; other site 465515000570 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 465515000571 conserved cys residue [active] 465515000572 Predicted amidohydrolase [General function prediction only]; Region: COG0388 465515000573 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 465515000574 putative active site [active] 465515000575 catalytic triad [active] 465515000576 putative dimer interface [polypeptide binding]; other site 465515000577 Transcriptional regulator [Transcription]; Region: IclR; COG1414 465515000578 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 465515000579 urocanate hydratase; Provisional; Region: PRK05414 465515000580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 465515000581 Nucleoside recognition; Region: Gate; pfam07670 465515000582 imidazolonepropionase; Provisional; Region: PRK14085 465515000583 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 465515000584 active site 465515000585 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 465515000586 active sites [active] 465515000587 tetramer interface [polypeptide binding]; other site 465515000588 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 465515000589 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 465515000590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465515000591 sequence-specific DNA binding site [nucleotide binding]; other site 465515000592 salt bridge; other site 465515000593 Domain of unknown function (DUF955); Region: DUF955; cl01076 465515000594 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 465515000595 putative active site [active] 465515000596 putative metal binding site [ion binding]; other site 465515000597 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 465515000598 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 465515000599 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 465515000600 homodimer interface [polypeptide binding]; other site 465515000601 substrate-cofactor binding pocket; other site 465515000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515000603 catalytic residue [active] 465515000604 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 465515000605 active site 465515000606 metal binding site [ion binding]; metal-binding site 465515000607 homotetramer interface [polypeptide binding]; other site 465515000608 Predicted membrane protein [General function prediction only]; Region: COG4194 465515000609 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 465515000610 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 465515000611 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 465515000612 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 465515000613 FAD binding pocket [chemical binding]; other site 465515000614 FAD binding motif [chemical binding]; other site 465515000615 phosphate binding motif [ion binding]; other site 465515000616 NAD binding pocket [chemical binding]; other site 465515000617 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 465515000618 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 465515000619 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 465515000620 metal binding site [ion binding]; metal-binding site 465515000621 dimer interface [polypeptide binding]; other site 465515000622 acetyl-CoA synthetase; Provisional; Region: PRK00174 465515000623 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515000624 acyl-activating enzyme (AAE) consensus motif; other site 465515000625 AMP binding site [chemical binding]; other site 465515000626 active site 465515000627 CoA binding site [chemical binding]; other site 465515000628 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 465515000629 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515000630 active site 465515000631 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 465515000632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515000633 dimer interface [polypeptide binding]; other site 465515000634 conserved gate region; other site 465515000635 putative PBP binding loops; other site 465515000636 ABC-ATPase subunit interface; other site 465515000637 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 465515000638 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 465515000639 non-prolyl cis peptide bond; other site 465515000640 active site 465515000641 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 465515000642 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 465515000643 dimerization interface [polypeptide binding]; other site 465515000644 ATP binding site [chemical binding]; other site 465515000645 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 465515000646 dimerization interface [polypeptide binding]; other site 465515000647 ATP binding site [chemical binding]; other site 465515000648 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 465515000649 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 465515000650 putative active site [active] 465515000651 catalytic triad [active] 465515000652 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 465515000653 hypothetical protein; Provisional; Region: PRK01842 465515000654 SEC-C motif; Region: SEC-C; pfam02810 465515000655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 465515000656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465515000657 salt bridge; other site 465515000658 non-specific DNA binding site [nucleotide binding]; other site 465515000659 sequence-specific DNA binding site [nucleotide binding]; other site 465515000660 Protein of unknown function (DUF952); Region: DUF952; cl01393 465515000661 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 465515000662 TAP-like protein; Region: Abhydrolase_4; pfam08386 465515000663 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 465515000664 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 465515000665 active site 465515000666 catalytic residues [active] 465515000667 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 465515000668 PA/protease or protease-like domain interface [polypeptide binding]; other site 465515000669 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 465515000670 catalytic residues [active] 465515000671 aspartate kinase; Reviewed; Region: PRK06635 465515000672 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 465515000673 putative nucleotide binding site [chemical binding]; other site 465515000674 putative catalytic residues [active] 465515000675 putative Mg ion binding site [ion binding]; other site 465515000676 putative aspartate binding site [chemical binding]; other site 465515000677 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 465515000678 putative allosteric regulatory site; other site 465515000679 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 465515000680 putative allosteric regulatory residue; other site 465515000681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 465515000682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 465515000683 Walker A/P-loop; other site 465515000684 ATP binding site [chemical binding]; other site 465515000685 Q-loop/lid; other site 465515000686 ABC transporter signature motif; other site 465515000687 Walker B; other site 465515000688 D-loop; other site 465515000689 H-loop/switch region; other site 465515000690 recombination protein RecR; Reviewed; Region: recR; PRK00076 465515000691 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 465515000692 RecR protein; Region: RecR; pfam02132 465515000693 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 465515000694 putative active site [active] 465515000695 putative metal-binding site [ion binding]; other site 465515000696 tetramer interface [polypeptide binding]; other site 465515000697 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 465515000698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515000699 Walker A motif; other site 465515000700 ATP binding site [chemical binding]; other site 465515000701 Walker B motif; other site 465515000702 arginine finger; other site 465515000703 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 465515000704 malonic semialdehyde reductase; Provisional; Region: PRK05365 465515000705 FMN binding site [chemical binding]; other site 465515000706 dimer interface [polypeptide binding]; other site 465515000707 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 465515000708 active site 465515000709 HIGH motif; other site 465515000710 nucleotide binding site [chemical binding]; other site 465515000711 active site 465515000712 KMSKS motif; other site 465515000713 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 465515000714 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 465515000715 pyruvate dehydrogenase; Provisional; Region: PRK09124 465515000716 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 465515000717 PYR/PP interface [polypeptide binding]; other site 465515000718 tetramer interface [polypeptide binding]; other site 465515000719 dimer interface [polypeptide binding]; other site 465515000720 TPP binding site [chemical binding]; other site 465515000721 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465515000722 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 465515000723 TPP-binding site [chemical binding]; other site 465515000724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515000725 motif I; other site 465515000726 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 465515000727 motif II; other site 465515000728 Staphylococcal nuclease homologues; Region: SNc; smart00318 465515000729 Catalytic site; other site 465515000730 Staphylococcal nuclease homologue; Region: SNase; pfam00565 465515000731 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 465515000732 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 465515000733 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 465515000734 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 465515000735 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 465515000736 nudix motif; other site 465515000737 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 465515000738 Ligand binding site [chemical binding]; other site 465515000739 Electron transfer flavoprotein domain; Region: ETF; pfam01012 465515000740 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 465515000741 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 465515000742 Ligand Binding Site [chemical binding]; other site 465515000743 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 465515000744 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 465515000745 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465515000746 active site 2 [active] 465515000747 active site 1 [active] 465515000748 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465515000749 active site 2 [active] 465515000750 active site 1 [active] 465515000751 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 465515000752 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515000753 active site 465515000754 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 465515000755 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465515000756 substrate binding site [chemical binding]; other site 465515000757 oxyanion hole (OAH) forming residues; other site 465515000758 trimer interface [polypeptide binding]; other site 465515000759 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 465515000760 enoyl-CoA hydratase; Provisional; Region: PRK05862 465515000761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465515000762 substrate binding site [chemical binding]; other site 465515000763 oxyanion hole (OAH) forming residues; other site 465515000764 trimer interface [polypeptide binding]; other site 465515000765 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 465515000766 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 465515000767 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 465515000768 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 465515000769 tetrameric interface [polypeptide binding]; other site 465515000770 NAD binding site [chemical binding]; other site 465515000771 catalytic residues [active] 465515000772 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 465515000773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515000774 NAD(P) binding site [chemical binding]; other site 465515000775 active site 465515000776 Transcriptional regulators [Transcription]; Region: MarR; COG1846 465515000777 MarR family; Region: MarR; pfam01047 465515000778 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 465515000779 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515000780 acyl-activating enzyme (AAE) consensus motif; other site 465515000781 AMP binding site [chemical binding]; other site 465515000782 active site 465515000783 CoA binding site [chemical binding]; other site 465515000784 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515000785 acyl-coenzyme A oxidase; Region: PLN02526 465515000786 active site 465515000787 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 465515000788 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 465515000789 glycine dehydrogenase; Provisional; Region: PRK05367 465515000790 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 465515000791 tetramer interface [polypeptide binding]; other site 465515000792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515000793 catalytic residue [active] 465515000794 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 465515000795 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465515000796 catalytic residue [active] 465515000797 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 465515000798 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 465515000799 Staphylococcal nuclease homologues; Region: SNc; smart00318 465515000800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465515000801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515000802 active site 465515000803 phosphorylation site [posttranslational modification] 465515000804 intermolecular recognition site; other site 465515000805 dimerization interface [polypeptide binding]; other site 465515000806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465515000807 DNA binding residues [nucleotide binding] 465515000808 dimerization interface [polypeptide binding]; other site 465515000809 Histidine kinase; Region: HisKA_3; pfam07730 465515000810 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 465515000811 ATP binding site [chemical binding]; other site 465515000812 Mg2+ binding site [ion binding]; other site 465515000813 G-X-G motif; other site 465515000814 Noc2p family; Region: Noc2; pfam03715 465515000815 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 465515000816 substrate binding site [chemical binding]; other site 465515000817 dimer interface [polypeptide binding]; other site 465515000818 ATP binding site [chemical binding]; other site 465515000819 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 465515000820 Uncharacterized conserved protein [Function unknown]; Region: COG1359 465515000821 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 465515000822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465515000823 Coenzyme A binding pocket [chemical binding]; other site 465515000824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515000825 acyl-coenzyme A oxidase; Region: PLN02526 465515000826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515000827 active site 465515000828 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 465515000829 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 465515000830 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 465515000831 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515000832 MULE transposase domain; Region: MULE; pfam10551 465515000833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515000834 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515000835 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 465515000836 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 465515000837 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 465515000838 catalytic triad [active] 465515000839 Homeodomain-like domain; Region: HTH_23; cl17451 465515000840 Winged helix-turn helix; Region: HTH_29; pfam13551 465515000841 Integrase core domain; Region: rve; pfam00665 465515000842 Integrase core domain; Region: rve_3; pfam13683 465515000843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465515000844 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 465515000845 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 465515000846 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 465515000847 phosphate binding site [ion binding]; other site 465515000848 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 465515000849 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 465515000850 active site 465515000851 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 465515000852 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 465515000853 oligomer interface; other site 465515000854 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 465515000855 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 465515000856 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 465515000857 putative DNA binding site [nucleotide binding]; other site 465515000858 catalytic residue [active] 465515000859 putative H2TH interface [polypeptide binding]; other site 465515000860 putative catalytic residues [active] 465515000861 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 465515000862 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 465515000863 dimer interface [polypeptide binding]; other site 465515000864 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 465515000865 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 465515000866 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 465515000867 nucleoside/Zn binding site; other site 465515000868 dimer interface [polypeptide binding]; other site 465515000869 catalytic motif [active] 465515000870 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465515000871 active site 465515000872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465515000873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465515000874 DNA binding site [nucleotide binding] 465515000875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465515000876 catalytic core [active] 465515000877 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 465515000878 active site 465515000879 substrate-binding site [chemical binding]; other site 465515000880 metal-binding site [ion binding] 465515000881 GTP binding site [chemical binding]; other site 465515000882 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515000883 MULE transposase domain; Region: MULE; pfam10551 465515000884 Integrase core domain; Region: rve; pfam00665 465515000885 Integrase core domain; Region: rve_2; pfam13333 465515000886 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 465515000887 alpha-gamma subunit interface [polypeptide binding]; other site 465515000888 beta-gamma subunit interface [polypeptide binding]; other site 465515000889 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 465515000890 gamma-beta subunit interface [polypeptide binding]; other site 465515000891 alpha-beta subunit interface [polypeptide binding]; other site 465515000892 urease subunit alpha; Reviewed; Region: ureC; PRK13207 465515000893 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 465515000894 subunit interactions [polypeptide binding]; other site 465515000895 active site 465515000896 flap region; other site 465515000897 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 465515000898 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 465515000899 dimer interface [polypeptide binding]; other site 465515000900 catalytic residues [active] 465515000901 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 465515000902 UreF; Region: UreF; pfam01730 465515000903 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 465515000904 UreD urease accessory protein; Region: UreD; cl00530 465515000905 High-affinity nickel-transport protein; Region: NicO; cl00964 465515000906 High-affinity nickel-transport protein; Region: NicO; cl00964 465515000907 Urea transporter; Region: UT; cl01829 465515000908 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 465515000909 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 465515000910 heme-binding site [chemical binding]; other site 465515000911 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 465515000912 FAD binding pocket [chemical binding]; other site 465515000913 FAD binding motif [chemical binding]; other site 465515000914 phosphate binding motif [ion binding]; other site 465515000915 beta-alpha-beta structure motif; other site 465515000916 NAD binding pocket [chemical binding]; other site 465515000917 Heme binding pocket [chemical binding]; other site 465515000918 Predicted transcriptional regulator [Transcription]; Region: COG1959 465515000919 Transcriptional regulator; Region: Rrf2; pfam02082 465515000920 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 465515000921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515000922 ATP binding site [chemical binding]; other site 465515000923 putative Mg++ binding site [ion binding]; other site 465515000924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515000925 nucleotide binding region [chemical binding]; other site 465515000926 ATP-binding site [chemical binding]; other site 465515000927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465515000928 active site 465515000929 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 465515000930 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 465515000931 active site 465515000932 substrate binding site [chemical binding]; other site 465515000933 metal binding site [ion binding]; metal-binding site 465515000934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515000935 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 465515000936 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 465515000937 PRC-barrel domain; Region: PRC; pfam05239 465515000938 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 465515000939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 465515000940 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 465515000941 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 465515000942 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 465515000943 generic binding surface II; other site 465515000944 generic binding surface I; other site 465515000945 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 465515000946 putative active site [active] 465515000947 putative catalytic site [active] 465515000948 putative Mg binding site IVb [ion binding]; other site 465515000949 putative phosphate binding site [ion binding]; other site 465515000950 putative DNA binding site [nucleotide binding]; other site 465515000951 putative Mg binding site IVa [ion binding]; other site 465515000952 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 465515000953 active site 465515000954 metal binding site [ion binding]; metal-binding site 465515000955 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 465515000956 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 465515000957 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 465515000958 NAD(P) binding site [chemical binding]; other site 465515000959 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 465515000960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515000961 motif II; other site 465515000962 DNA polymerase III subunit delta'; Validated; Region: PRK07940 465515000963 DNA polymerase III subunit delta'; Validated; Region: PRK08485 465515000964 thymidylate kinase; Validated; Region: tmk; PRK00698 465515000965 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 465515000966 TMP-binding site; other site 465515000967 ATP-binding site [chemical binding]; other site 465515000968 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 465515000969 Methyltransferase domain; Region: Methyltransf_18; pfam12847 465515000970 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465515000971 catalytic core [active] 465515000972 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 465515000973 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 465515000974 PhoU domain; Region: PhoU; pfam01895 465515000975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465515000976 dimer interface [polypeptide binding]; other site 465515000977 phosphorylation site [posttranslational modification] 465515000978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515000979 ATP binding site [chemical binding]; other site 465515000980 Mg2+ binding site [ion binding]; other site 465515000981 G-X-G motif; other site 465515000982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465515000983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515000984 active site 465515000985 phosphorylation site [posttranslational modification] 465515000986 intermolecular recognition site; other site 465515000987 dimerization interface [polypeptide binding]; other site 465515000988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465515000989 DNA binding site [nucleotide binding] 465515000990 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 465515000991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 465515000992 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 465515000993 homotrimer interaction site [polypeptide binding]; other site 465515000994 zinc binding site [ion binding]; other site 465515000995 CDP-binding sites; other site 465515000996 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 465515000997 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465515000998 active site 465515000999 HIGH motif; other site 465515001000 nucleotide binding site [chemical binding]; other site 465515001001 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 465515001002 KMSKS motif; other site 465515001003 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 465515001004 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 465515001005 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 465515001006 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 465515001007 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 465515001008 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 465515001009 zinc binding site [ion binding]; other site 465515001010 putative ligand binding site [chemical binding]; other site 465515001011 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465515001012 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 465515001013 TM-ABC transporter signature motif; other site 465515001014 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 465515001015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515001016 Walker A/P-loop; other site 465515001017 ATP binding site [chemical binding]; other site 465515001018 Q-loop/lid; other site 465515001019 ABC transporter signature motif; other site 465515001020 Walker B; other site 465515001021 D-loop; other site 465515001022 H-loop/switch region; other site 465515001023 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 465515001024 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 465515001025 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 465515001026 active site 465515001027 catalytic site [active] 465515001028 glycogen branching enzyme; Provisional; Region: PRK05402 465515001029 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 465515001030 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 465515001031 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 465515001032 active site 465515001033 catalytic site [active] 465515001034 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 465515001035 Predicted acetyltransferase [General function prediction only]; Region: COG2388 465515001036 Uncharacterized conserved protein [Function unknown]; Region: COG2128 465515001037 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 465515001038 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 465515001039 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 465515001040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465515001041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465515001042 active site 465515001043 catalytic tetrad [active] 465515001044 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 465515001045 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 465515001046 active site 465515001047 catalytic site [active] 465515001048 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 465515001049 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 465515001050 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 465515001051 catalytic site [active] 465515001052 active site 465515001053 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 465515001054 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 465515001055 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 465515001056 catalytic residues [active] 465515001057 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 465515001058 active site 465515001059 catalytic triad [active] 465515001060 Uncharacterized conserved protein [Function unknown]; Region: COG2966 465515001061 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 465515001062 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 465515001063 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 465515001064 ligand binding site [chemical binding]; other site 465515001065 active site 465515001066 UGI interface [polypeptide binding]; other site 465515001067 catalytic site [active] 465515001068 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 465515001069 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 465515001070 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 465515001071 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 465515001072 ring oligomerisation interface [polypeptide binding]; other site 465515001073 ATP/Mg binding site [chemical binding]; other site 465515001074 stacking interactions; other site 465515001075 hinge regions; other site 465515001076 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 465515001077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 465515001078 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 465515001079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 465515001080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465515001081 dimerization interface [polypeptide binding]; other site 465515001082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465515001083 dimer interface [polypeptide binding]; other site 465515001084 phosphorylation site [posttranslational modification] 465515001085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515001086 ATP binding site [chemical binding]; other site 465515001087 Mg2+ binding site [ion binding]; other site 465515001088 G-X-G motif; other site 465515001089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465515001090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515001091 active site 465515001092 phosphorylation site [posttranslational modification] 465515001093 intermolecular recognition site; other site 465515001094 dimerization interface [polypeptide binding]; other site 465515001095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465515001096 DNA binding site [nucleotide binding] 465515001097 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 465515001098 DNA-binding site [nucleotide binding]; DNA binding site 465515001099 RNA-binding motif; other site 465515001100 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 465515001101 phosphoserine aminotransferase; Provisional; Region: PRK03080 465515001102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465515001103 catalytic residue [active] 465515001104 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 465515001105 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 465515001106 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 465515001107 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 465515001108 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 465515001109 active site 465515001110 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 465515001111 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465515001112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515001113 Walker A/P-loop; other site 465515001114 ATP binding site [chemical binding]; other site 465515001115 Q-loop/lid; other site 465515001116 ABC transporter signature motif; other site 465515001117 Walker B; other site 465515001118 D-loop; other site 465515001119 H-loop/switch region; other site 465515001120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 465515001121 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 465515001122 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 465515001123 Part of AAA domain; Region: AAA_19; pfam13245 465515001124 Family description; Region: UvrD_C_2; pfam13538 465515001125 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 465515001126 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 465515001127 CoA-ligase; Region: Ligase_CoA; pfam00549 465515001128 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 465515001129 CoA binding domain; Region: CoA_binding; smart00881 465515001130 CoA-ligase; Region: Ligase_CoA; pfam00549 465515001131 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 465515001132 diiron binding motif [ion binding]; other site 465515001133 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 465515001134 Domain of unknown function (DUF202); Region: DUF202; cl09954 465515001135 Domain of unknown function (DUF202); Region: DUF202; pfam02656 465515001136 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 465515001137 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 465515001138 NAD binding site [chemical binding]; other site 465515001139 catalytic Zn binding site [ion binding]; other site 465515001140 structural Zn binding site [ion binding]; other site 465515001141 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 465515001142 Na binding site [ion binding]; other site 465515001143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465515001144 sequence-specific DNA binding site [nucleotide binding]; other site 465515001145 salt bridge; other site 465515001146 Cupin domain; Region: Cupin_2; pfam07883 465515001147 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 465515001148 agmatinase; Region: agmatinase; TIGR01230 465515001149 oligomer interface [polypeptide binding]; other site 465515001150 putative active site [active] 465515001151 Mn binding site [ion binding]; other site 465515001152 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 465515001153 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 465515001154 PYR/PP interface [polypeptide binding]; other site 465515001155 dimer interface [polypeptide binding]; other site 465515001156 TPP binding site [chemical binding]; other site 465515001157 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465515001158 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 465515001159 TPP-binding site [chemical binding]; other site 465515001160 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 465515001161 active site 465515001162 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 465515001163 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 465515001164 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 465515001165 active site 465515001166 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 465515001167 nudix motif; other site 465515001168 Uncharacterized conserved protein [Function unknown]; Region: COG4850 465515001169 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 465515001170 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 465515001171 active site 465515001172 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 465515001173 glutamate dehydrogenase; Provisional; Region: PRK09414 465515001174 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 465515001175 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 465515001176 NAD(P) binding site [chemical binding]; other site 465515001177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515001178 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 465515001179 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 465515001180 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 465515001181 active site 465515001182 substrate binding site [chemical binding]; other site 465515001183 cosubstrate binding site; other site 465515001184 catalytic site [active] 465515001185 benzoate transport; Region: 2A0115; TIGR00895 465515001186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515001187 putative substrate translocation pore; other site 465515001188 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 465515001189 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 465515001190 purine monophosphate binding site [chemical binding]; other site 465515001191 dimer interface [polypeptide binding]; other site 465515001192 putative catalytic residues [active] 465515001193 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 465515001194 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 465515001195 MgtE intracellular N domain; Region: MgtE_N; smart00924 465515001196 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 465515001197 Divalent cation transporter; Region: MgtE; cl00786 465515001198 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 465515001199 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 465515001200 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 465515001201 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 465515001202 putative hydrophobic ligand binding site [chemical binding]; other site 465515001203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515001204 TIGR01777 family protein; Region: yfcH 465515001205 NAD(P) binding site [chemical binding]; other site 465515001206 active site 465515001207 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 465515001208 Glutaminase; Region: Glutaminase; cl00907 465515001209 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 465515001210 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 465515001211 ligand binding site [chemical binding]; other site 465515001212 flexible hinge region; other site 465515001213 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 465515001214 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 465515001215 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 465515001216 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 465515001217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 465515001218 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 465515001219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515001220 dimer interface [polypeptide binding]; other site 465515001221 conserved gate region; other site 465515001222 putative PBP binding loops; other site 465515001223 ABC-ATPase subunit interface; other site 465515001224 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 465515001225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515001226 dimer interface [polypeptide binding]; other site 465515001227 conserved gate region; other site 465515001228 putative PBP binding loops; other site 465515001229 ABC-ATPase subunit interface; other site 465515001230 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 465515001231 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 465515001232 Walker A/P-loop; other site 465515001233 ATP binding site [chemical binding]; other site 465515001234 Q-loop/lid; other site 465515001235 ABC transporter signature motif; other site 465515001236 Walker B; other site 465515001237 D-loop; other site 465515001238 H-loop/switch region; other site 465515001239 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 465515001240 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 465515001241 putative ligand binding site [chemical binding]; other site 465515001242 putative NAD binding site [chemical binding]; other site 465515001243 catalytic site [active] 465515001244 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 465515001245 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 465515001246 trimer interface [polypeptide binding]; other site 465515001247 putative metal binding site [ion binding]; other site 465515001248 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 465515001249 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 465515001250 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 465515001251 putative active site [active] 465515001252 putative substrate binding site [chemical binding]; other site 465515001253 putative cosubstrate binding site; other site 465515001254 catalytic site [active] 465515001255 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 465515001256 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 465515001257 tetramer interface [polypeptide binding]; other site 465515001258 heme binding pocket [chemical binding]; other site 465515001259 NADPH binding site [chemical binding]; other site 465515001260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515001261 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515001262 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 465515001263 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 465515001264 dimer interface [polypeptide binding]; other site 465515001265 active site 465515001266 glycine-pyridoxal phosphate binding site [chemical binding]; other site 465515001267 folate binding site [chemical binding]; other site 465515001268 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 465515001269 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 465515001270 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 465515001271 homodimer interface [polypeptide binding]; other site 465515001272 NADP binding site [chemical binding]; other site 465515001273 substrate binding site [chemical binding]; other site 465515001274 myosin-cross-reactive antigen; Provisional; Region: PRK13977 465515001275 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 465515001276 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 465515001277 Walker A/P-loop; other site 465515001278 ATP binding site [chemical binding]; other site 465515001279 Q-loop/lid; other site 465515001280 ABC transporter signature motif; other site 465515001281 Walker B; other site 465515001282 D-loop; other site 465515001283 H-loop/switch region; other site 465515001284 ABC-2 type transporter; Region: ABC2_membrane; cl17235 465515001285 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 465515001286 ABC-2 type transporter; Region: ABC2_membrane; cl17235 465515001287 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 465515001288 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 465515001289 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 465515001290 putative active site [active] 465515001291 putative catalytic site [active] 465515001292 putative DNA binding site [nucleotide binding]; other site 465515001293 putative phosphate binding site [ion binding]; other site 465515001294 metal binding site A [ion binding]; metal-binding site 465515001295 putative AP binding site [nucleotide binding]; other site 465515001296 putative metal binding site B [ion binding]; other site 465515001297 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 465515001298 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 465515001299 active site 465515001300 HIGH motif; other site 465515001301 dimer interface [polypeptide binding]; other site 465515001302 KMSKS motif; other site 465515001303 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465515001304 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 465515001305 Walker A/P-loop; other site 465515001306 ATP binding site [chemical binding]; other site 465515001307 Q-loop/lid; other site 465515001308 ABC transporter signature motif; other site 465515001309 Walker B; other site 465515001310 D-loop; other site 465515001311 H-loop/switch region; other site 465515001312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 465515001313 FtsX-like permease family; Region: FtsX; pfam02687 465515001314 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 465515001315 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 465515001316 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 465515001317 L-aspartate oxidase; Provisional; Region: PRK06175 465515001318 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 465515001319 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 465515001320 putative Iron-sulfur protein interface [polypeptide binding]; other site 465515001321 putative proximal heme binding site [chemical binding]; other site 465515001322 putative SdhC-like subunit interface [polypeptide binding]; other site 465515001323 putative distal heme binding site [chemical binding]; other site 465515001324 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 465515001325 putative Iron-sulfur protein interface [polypeptide binding]; other site 465515001326 putative proximal heme binding site [chemical binding]; other site 465515001327 putative SdhD-like interface [polypeptide binding]; other site 465515001328 putative distal heme binding site [chemical binding]; other site 465515001329 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 465515001330 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 465515001331 Substrate binding site; other site 465515001332 Cupin domain; Region: Cupin_2; cl17218 465515001333 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 465515001334 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 465515001335 metal binding site [ion binding]; metal-binding site 465515001336 putative dimer interface [polypeptide binding]; other site 465515001337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515001338 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515001339 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 465515001340 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 465515001341 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 465515001342 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 465515001343 Walker A/P-loop; other site 465515001344 ATP binding site [chemical binding]; other site 465515001345 Q-loop/lid; other site 465515001346 ABC transporter signature motif; other site 465515001347 Walker B; other site 465515001348 D-loop; other site 465515001349 H-loop/switch region; other site 465515001350 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 465515001351 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465515001352 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 465515001353 TM-ABC transporter signature motif; other site 465515001354 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465515001355 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 465515001356 TM-ABC transporter signature motif; other site 465515001357 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 465515001358 active site 465515001359 catalytic motif [active] 465515001360 Zn binding site [ion binding]; other site 465515001361 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 465515001362 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 465515001363 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 465515001364 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 465515001365 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 465515001366 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 465515001367 adenosine deaminase; Provisional; Region: PRK09358 465515001368 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 465515001369 active site 465515001370 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 465515001371 homodimer interface [polypeptide binding]; other site 465515001372 metal binding site [ion binding]; metal-binding site 465515001373 enolase; Provisional; Region: eno; PRK00077 465515001374 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 465515001375 dimer interface [polypeptide binding]; other site 465515001376 metal binding site [ion binding]; metal-binding site 465515001377 substrate binding pocket [chemical binding]; other site 465515001378 Septum formation initiator; Region: DivIC; pfam04977 465515001379 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 465515001380 Protein of unknown function (DUF501); Region: DUF501; cl00652 465515001381 exopolyphosphatase; Region: exo_poly_only; TIGR03706 465515001382 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 465515001383 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 465515001384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515001385 Bax inhibitor 1 like; Region: BaxI_1; cl17691 465515001386 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 465515001387 active site 465515001388 catalytic residues [active] 465515001389 Domain of unknown function DUF20; Region: UPF0118; pfam01594 465515001390 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 465515001391 threonine dehydratase; Provisional; Region: PRK08198 465515001392 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 465515001393 tetramer interface [polypeptide binding]; other site 465515001394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515001395 catalytic residue [active] 465515001396 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 465515001397 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 465515001398 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 465515001399 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 465515001400 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 465515001401 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 465515001402 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 465515001403 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 465515001404 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 465515001405 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 465515001406 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 465515001407 catalytic residue [active] 465515001408 putative FPP diphosphate binding site; other site 465515001409 putative FPP binding hydrophobic cleft; other site 465515001410 dimer interface [polypeptide binding]; other site 465515001411 putative IPP diphosphate binding site; other site 465515001412 Rhomboid family; Region: Rhomboid; cl11446 465515001413 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 465515001414 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 465515001415 putative active site [active] 465515001416 PhoH-like protein; Region: PhoH; pfam02562 465515001417 fumarate hydratase; Reviewed; Region: fumC; PRK00485 465515001418 Class II fumarases; Region: Fumarase_classII; cd01362 465515001419 active site 465515001420 tetramer interface [polypeptide binding]; other site 465515001421 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 465515001422 active site clefts [active] 465515001423 zinc binding site [ion binding]; other site 465515001424 dimer interface [polypeptide binding]; other site 465515001425 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 465515001426 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 465515001427 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 465515001428 putative active site [active] 465515001429 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 465515001430 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 465515001431 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 465515001432 Transcriptional regulator [Transcription]; Region: LytR; COG1316 465515001433 AIR carboxylase; Region: AIRC; pfam00731 465515001434 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 465515001435 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465515001436 Predicted membrane protein [Function unknown]; Region: COG2246 465515001437 GtrA-like protein; Region: GtrA; pfam04138 465515001438 TIGR03089 family protein; Region: TIGR03089 465515001439 Transcription factor WhiB; Region: Whib; pfam02467 465515001440 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 465515001441 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 465515001442 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 465515001443 Winged helix-turn helix; Region: HTH_29; pfam13551 465515001444 Integrase core domain; Region: rve; pfam00665 465515001445 Integrase core domain; Region: rve_3; pfam13683 465515001446 Adenosylhomocysteinase; Provisional; Region: PTZ00075 465515001447 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 465515001448 homotetramer interface [polypeptide binding]; other site 465515001449 ligand binding site [chemical binding]; other site 465515001450 catalytic site [active] 465515001451 NAD binding site [chemical binding]; other site 465515001452 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 465515001453 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 465515001454 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 465515001455 acyl-activating enzyme (AAE) consensus motif; other site 465515001456 putative AMP binding site [chemical binding]; other site 465515001457 putative active site [active] 465515001458 putative CoA binding site [chemical binding]; other site 465515001459 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 465515001460 Predicted methyltransferases [General function prediction only]; Region: COG0313 465515001461 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 465515001462 putative SAM binding site [chemical binding]; other site 465515001463 putative homodimer interface [polypeptide binding]; other site 465515001464 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 465515001465 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 465515001466 tetramerization interface [polypeptide binding]; other site 465515001467 NAD(P) binding site [chemical binding]; other site 465515001468 catalytic residues [active] 465515001469 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 465515001470 active site 465515001471 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 465515001472 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 465515001473 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 465515001474 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 465515001475 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 465515001476 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465515001477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465515001478 ABC transporter; Region: ABC_tran_2; pfam12848 465515001479 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465515001480 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515001481 MULE transposase domain; Region: MULE; pfam10551 465515001482 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 465515001483 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 465515001484 Substrate binding site; other site 465515001485 Mg++ binding site; other site 465515001486 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 465515001487 active site 465515001488 substrate binding site [chemical binding]; other site 465515001489 CoA binding site [chemical binding]; other site 465515001490 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 465515001491 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 465515001492 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 465515001493 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465515001494 active site 465515001495 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 465515001496 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 465515001497 Catalytic site [active] 465515001498 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 465515001499 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 465515001500 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 465515001501 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 465515001502 5S rRNA interface [nucleotide binding]; other site 465515001503 CTC domain interface [polypeptide binding]; other site 465515001504 L16 interface [polypeptide binding]; other site 465515001505 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 465515001506 putative active site [active] 465515001507 catalytic residue [active] 465515001508 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 465515001509 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 465515001510 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 465515001511 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 465515001512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515001513 ATP binding site [chemical binding]; other site 465515001514 putative Mg++ binding site [ion binding]; other site 465515001515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515001516 nucleotide binding region [chemical binding]; other site 465515001517 ATP-binding site [chemical binding]; other site 465515001518 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 465515001519 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 465515001520 Acyltransferase family; Region: Acyl_transf_3; pfam01757 465515001521 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 465515001522 intersubunit interface [polypeptide binding]; other site 465515001523 active site 465515001524 catalytic residue [active] 465515001525 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 465515001526 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 465515001527 active site 465515001528 substrate binding site [chemical binding]; other site 465515001529 metal binding site [ion binding]; metal-binding site 465515001530 purine nucleoside phosphorylase; Provisional; Region: PRK08202 465515001531 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 465515001532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515001533 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 465515001534 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 465515001535 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 465515001536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515001537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515001538 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 465515001539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515001540 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 465515001541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515001542 metabolite-proton symporter; Region: 2A0106; TIGR00883 465515001543 putative substrate translocation pore; other site 465515001544 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 465515001545 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465515001546 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 465515001547 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 465515001548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 465515001549 carboxyltransferase (CT) interaction site; other site 465515001550 biotinylation site [posttranslational modification]; other site 465515001551 Maf-like protein; Region: Maf; pfam02545 465515001552 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 465515001553 putative active site [active] 465515001554 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 465515001555 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 465515001556 active site 465515001557 catalytic triad [active] 465515001558 oxyanion hole [active] 465515001559 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515001560 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 465515001561 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 465515001562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515001563 NAD(P) binding site [chemical binding]; other site 465515001564 active site 465515001565 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 465515001566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465515001567 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465515001568 active site 465515001569 catalytic tetrad [active] 465515001570 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 465515001571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 465515001572 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 465515001573 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 465515001574 putative trimer interface [polypeptide binding]; other site 465515001575 putative active site [active] 465515001576 putative substrate binding site [chemical binding]; other site 465515001577 putative CoA binding site [chemical binding]; other site 465515001578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515001579 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465515001580 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 465515001581 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515001582 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 465515001583 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 465515001584 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 465515001585 Chain length determinant protein; Region: Wzz; pfam02706 465515001586 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 465515001587 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 465515001588 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 465515001589 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 465515001590 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 465515001591 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 465515001592 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 465515001593 Bacterial PH domain; Region: DUF304; pfam03703 465515001594 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 465515001595 DNA binding residues [nucleotide binding] 465515001596 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 465515001597 cyclase homology domain; Region: CHD; cd07302 465515001598 nucleotidyl binding site; other site 465515001599 metal binding site [ion binding]; metal-binding site 465515001600 dimer interface [polypeptide binding]; other site 465515001601 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 465515001602 Protein phosphatase 2C; Region: PP2C; pfam00481 465515001603 active site 465515001604 Ligase N family; Region: LIGANc; smart00532 465515001605 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 465515001606 nucleotide binding pocket [chemical binding]; other site 465515001607 K-X-D-G motif; other site 465515001608 catalytic site [active] 465515001609 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 465515001610 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 465515001611 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 465515001612 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 465515001613 Dimer interface [polypeptide binding]; other site 465515001614 BRCT sequence motif; other site 465515001615 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 465515001616 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 465515001617 active site 465515001618 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 465515001619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 465515001620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465515001621 Coenzyme A binding pocket [chemical binding]; other site 465515001622 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 465515001623 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 465515001624 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 465515001625 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 465515001626 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 465515001627 GatB domain; Region: GatB_Yqey; smart00845 465515001628 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 465515001629 substrate binding site [chemical binding]; other site 465515001630 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 465515001631 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 465515001632 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 465515001633 homodimer interface [polypeptide binding]; other site 465515001634 substrate-cofactor binding pocket; other site 465515001635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515001636 catalytic residue [active] 465515001637 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 465515001638 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 465515001639 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 465515001640 active site 465515001641 catalytic triad [active] 465515001642 oxyanion hole [active] 465515001643 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 465515001644 Serine hydrolase (FSH1); Region: FSH1; pfam03959 465515001645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465515001646 RNA binding surface [nucleotide binding]; other site 465515001647 glycyl-tRNA synthetase; Provisional; Region: PRK04173 465515001648 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 465515001649 dimer interface [polypeptide binding]; other site 465515001650 motif 1; other site 465515001651 active site 465515001652 motif 2; other site 465515001653 motif 3; other site 465515001654 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 465515001655 anticodon binding site; other site 465515001656 Cation efflux family; Region: Cation_efflux; cl00316 465515001657 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 465515001658 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 465515001659 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 465515001660 DNA binding residues [nucleotide binding] 465515001661 dimer interface [polypeptide binding]; other site 465515001662 metal binding site [ion binding]; metal-binding site 465515001663 mercuric reductase; Region: MerA; TIGR02053 465515001664 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515001665 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 465515001666 Plasmid replication protein; Region: Rep_2; pfam01719 465515001667 RNA helicase; Region: RNA_helicase; pfam00910 465515001668 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 465515001669 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 465515001670 catalytic residues [active] 465515001671 Recombinase; Region: Recombinase; pfam07508 465515001672 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 465515001673 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 465515001674 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 465515001675 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 465515001676 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 465515001677 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 465515001678 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 465515001679 FMN binding site [chemical binding]; other site 465515001680 active site 465515001681 catalytic residues [active] 465515001682 substrate binding site [chemical binding]; other site 465515001683 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 465515001684 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 465515001685 Zn2+ binding site [ion binding]; other site 465515001686 Mg2+ binding site [ion binding]; other site 465515001687 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 465515001688 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 465515001689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515001690 Walker A/P-loop; other site 465515001691 ATP binding site [chemical binding]; other site 465515001692 Q-loop/lid; other site 465515001693 ABC transporter signature motif; other site 465515001694 Walker B; other site 465515001695 D-loop; other site 465515001696 H-loop/switch region; other site 465515001697 TOBE domain; Region: TOBE_2; pfam08402 465515001698 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 465515001699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515001700 dimer interface [polypeptide binding]; other site 465515001701 conserved gate region; other site 465515001702 putative PBP binding loops; other site 465515001703 ABC-ATPase subunit interface; other site 465515001704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 465515001705 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 465515001706 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 465515001707 NAD-dependent deacetylase; Provisional; Region: PRK00481 465515001708 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 465515001709 NAD+ binding site [chemical binding]; other site 465515001710 substrate binding site [chemical binding]; other site 465515001711 Zn binding site [ion binding]; other site 465515001712 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 465515001713 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 465515001714 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 465515001715 CHC2 zinc finger; Region: zf-CHC2; pfam01807 465515001716 DNA primase, catalytic core; Region: dnaG; TIGR01391 465515001717 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 465515001718 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 465515001719 active site 465515001720 metal binding site [ion binding]; metal-binding site 465515001721 interdomain interaction site; other site 465515001722 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 465515001723 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 465515001724 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 465515001725 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 465515001726 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 465515001727 Helix-turn-helix domain; Region: HTH_36; pfam13730 465515001728 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 465515001729 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465515001730 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 465515001731 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515001732 MULE transposase domain; Region: MULE; pfam10551 465515001733 AAA-like domain; Region: AAA_10; pfam12846 465515001734 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 465515001735 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465515001736 Walker A motif; other site 465515001737 ATP binding site [chemical binding]; other site 465515001738 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 465515001739 Protein of unknown function (DUF968); Region: DUF968; pfam06147 465515001740 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515001741 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515001742 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515001743 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 465515001744 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515001745 putative transposase OrfB; Reviewed; Region: PHA02517 465515001746 HTH-like domain; Region: HTH_21; pfam13276 465515001747 Integrase core domain; Region: rve; pfam00665 465515001748 Integrase core domain; Region: rve_2; pfam13333 465515001749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 465515001750 Transposase; Region: HTH_Tnp_1; pfam01527 465515001751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465515001752 active site 465515001753 DNA binding site [nucleotide binding] 465515001754 Int/Topo IB signature motif; other site 465515001755 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465515001756 active site 465515001757 DNA binding site [nucleotide binding] 465515001758 Int/Topo IB signature motif; other site 465515001759 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 465515001760 TAP-like protein; Region: Abhydrolase_4; pfam08386 465515001761 Protein of unknown function DUF72; Region: DUF72; pfam01904 465515001762 oxidoreductase; Provisional; Region: PRK06128 465515001763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515001764 NAD(P) binding site [chemical binding]; other site 465515001765 active site 465515001766 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 465515001767 active site 465515001768 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465515001769 active site 465515001770 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465515001771 catalytic tetrad [active] 465515001772 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 465515001773 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 465515001774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515001775 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 465515001776 putative ADP-binding pocket [chemical binding]; other site 465515001777 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515001778 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515001779 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 465515001780 NlpC/P60 family; Region: NLPC_P60; pfam00877 465515001781 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465515001782 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515001783 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 465515001784 rRNA interaction site [nucleotide binding]; other site 465515001785 S8 interaction site; other site 465515001786 putative laminin-1 binding site; other site 465515001787 elongation factor Ts; Provisional; Region: tsf; PRK09377 465515001788 UBA/TS-N domain; Region: UBA; pfam00627 465515001789 Elongation factor TS; Region: EF_TS; pfam00889 465515001790 Elongation factor TS; Region: EF_TS; pfam00889 465515001791 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 465515001792 putative nucleotide binding site [chemical binding]; other site 465515001793 uridine monophosphate binding site [chemical binding]; other site 465515001794 homohexameric interface [polypeptide binding]; other site 465515001795 ribosome recycling factor; Reviewed; Region: frr; PRK00083 465515001796 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 465515001797 hinge region; other site 465515001798 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 465515001799 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 465515001800 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 465515001801 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 465515001802 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 465515001803 tetramer interface [polypeptide binding]; other site 465515001804 TPP-binding site [chemical binding]; other site 465515001805 heterodimer interface [polypeptide binding]; other site 465515001806 phosphorylation loop region [posttranslational modification] 465515001807 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 465515001808 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 465515001809 alpha subunit interface [polypeptide binding]; other site 465515001810 TPP binding site [chemical binding]; other site 465515001811 heterodimer interface [polypeptide binding]; other site 465515001812 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 465515001813 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 465515001814 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465515001815 E3 interaction surface; other site 465515001816 lipoyl attachment site [posttranslational modification]; other site 465515001817 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 465515001818 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465515001819 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515001820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465515001821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515001822 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 465515001823 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 465515001824 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 465515001825 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 465515001826 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465515001827 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465515001828 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 465515001829 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 465515001830 carboxyltransferase (CT) interaction site; other site 465515001831 biotinylation site [posttranslational modification]; other site 465515001832 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 465515001833 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515001834 active site 465515001835 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 465515001836 putative active site [active] 465515001837 putative catalytic site [active] 465515001838 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 465515001839 Protein of unknown function, DUF485; Region: DUF485; pfam04341 465515001840 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 465515001841 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 465515001842 Na binding site [ion binding]; other site 465515001843 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 465515001844 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 465515001845 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 465515001846 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 465515001847 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 465515001848 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 465515001849 active site 465515001850 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 465515001851 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 465515001852 putative substrate binding region [chemical binding]; other site 465515001853 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 465515001854 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 465515001855 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 465515001856 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 465515001857 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515001858 prolyl-tRNA synthetase; Provisional; Region: PRK09194 465515001859 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 465515001860 dimer interface [polypeptide binding]; other site 465515001861 motif 1; other site 465515001862 active site 465515001863 motif 2; other site 465515001864 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 465515001865 putative deacylase active site [active] 465515001866 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 465515001867 active site 465515001868 motif 3; other site 465515001869 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 465515001870 anticodon binding site; other site 465515001871 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 465515001872 hypothetical protein; Provisional; Region: PRK10621 465515001873 Sm and related proteins; Region: Sm_like; cl00259 465515001874 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 465515001875 putative RNA binding site [nucleotide binding]; other site 465515001876 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 465515001877 NusA N-terminal domain; Region: NusA_N; pfam08529 465515001878 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 465515001879 RNA binding site [nucleotide binding]; other site 465515001880 homodimer interface [polypeptide binding]; other site 465515001881 NusA-like KH domain; Region: KH_5; pfam13184 465515001882 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 465515001883 G-X-X-G motif; other site 465515001884 Protein of unknown function (DUF448); Region: DUF448; pfam04296 465515001885 putative RNA binding cleft [nucleotide binding]; other site 465515001886 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 465515001887 translation initiation factor IF-2; Region: IF-2; TIGR00487 465515001888 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 465515001889 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 465515001890 G1 box; other site 465515001891 putative GEF interaction site [polypeptide binding]; other site 465515001892 GTP/Mg2+ binding site [chemical binding]; other site 465515001893 Switch I region; other site 465515001894 G2 box; other site 465515001895 G3 box; other site 465515001896 Switch II region; other site 465515001897 G4 box; other site 465515001898 G5 box; other site 465515001899 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 465515001900 Translation-initiation factor 2; Region: IF-2; pfam11987 465515001901 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 465515001902 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 465515001903 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 465515001904 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 465515001905 RNA binding site [nucleotide binding]; other site 465515001906 active site 465515001907 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 465515001908 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 465515001909 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465515001910 active site 465515001911 nucleotide binding site [chemical binding]; other site 465515001912 HIGH motif; other site 465515001913 KMSKS motif; other site 465515001914 Riboflavin kinase; Region: Flavokinase; pfam01687 465515001915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515001916 S-adenosylmethionine binding site [chemical binding]; other site 465515001917 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 465515001918 16S/18S rRNA binding site [nucleotide binding]; other site 465515001919 S13e-L30e interaction site [polypeptide binding]; other site 465515001920 25S rRNA binding site [nucleotide binding]; other site 465515001921 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 465515001922 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 465515001923 oligomer interface [polypeptide binding]; other site 465515001924 RNA binding site [nucleotide binding]; other site 465515001925 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 465515001926 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 465515001927 RNase E interface [polypeptide binding]; other site 465515001928 trimer interface [polypeptide binding]; other site 465515001929 active site 465515001930 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 465515001931 putative nucleic acid binding region [nucleotide binding]; other site 465515001932 G-X-X-G motif; other site 465515001933 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 465515001934 RNA binding site [nucleotide binding]; other site 465515001935 domain interface; other site 465515001936 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 465515001937 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 465515001938 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 465515001939 dihydrodipicolinate reductase; Provisional; Region: PRK00048 465515001940 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 465515001941 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 465515001942 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 465515001943 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 465515001944 dimer interface [polypeptide binding]; other site 465515001945 active site 465515001946 catalytic residue [active] 465515001947 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 465515001948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 465515001949 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 465515001950 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 465515001951 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 465515001952 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 465515001953 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 465515001954 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 465515001955 Competence-damaged protein; Region: CinA; pfam02464 465515001956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465515001957 non-specific DNA binding site [nucleotide binding]; other site 465515001958 salt bridge; other site 465515001959 sequence-specific DNA binding site [nucleotide binding]; other site 465515001960 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 465515001961 recombinase A; Provisional; Region: recA; PRK09354 465515001962 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 465515001963 hexamer interface [polypeptide binding]; other site 465515001964 Walker A motif; other site 465515001965 ATP binding site [chemical binding]; other site 465515001966 Walker B motif; other site 465515001967 recombination regulator RecX; Reviewed; Region: recX; PRK00117 465515001968 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 465515001969 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 465515001970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465515001971 FeS/SAM binding site; other site 465515001972 TRAM domain; Region: TRAM; cl01282 465515001973 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 465515001974 IPP transferase; Region: IPPT; pfam01715 465515001975 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 465515001976 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 465515001977 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 465515001978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515001979 S-adenosylmethionine binding site [chemical binding]; other site 465515001980 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 465515001981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515001982 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 465515001983 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 465515001984 HflX GTPase family; Region: HflX; cd01878 465515001985 G1 box; other site 465515001986 GTP/Mg2+ binding site [chemical binding]; other site 465515001987 Switch I region; other site 465515001988 G2 box; other site 465515001989 G3 box; other site 465515001990 Switch II region; other site 465515001991 G4 box; other site 465515001992 G5 box; other site 465515001993 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 465515001994 DEAD/DEAH box helicase; Region: DEAD; pfam00270 465515001995 ATP binding site [chemical binding]; other site 465515001996 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 465515001997 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 465515001998 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 465515001999 transmembrane helices; other site 465515002000 LexA repressor; Validated; Region: PRK00215 465515002001 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 465515002002 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 465515002003 Catalytic site [active] 465515002004 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 465515002005 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 465515002006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465515002007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515002008 homodimer interface [polypeptide binding]; other site 465515002009 catalytic residue [active] 465515002010 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 465515002011 putative active site pocket [active] 465515002012 4-fold oligomerization interface [polypeptide binding]; other site 465515002013 metal binding residues [ion binding]; metal-binding site 465515002014 3-fold/trimer interface [polypeptide binding]; other site 465515002015 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 465515002016 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 465515002017 putative active site [active] 465515002018 oxyanion strand; other site 465515002019 catalytic triad [active] 465515002020 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 465515002021 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 465515002022 catalytic residues [active] 465515002023 MarR family; Region: MarR_2; pfam12802 465515002024 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 465515002025 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 465515002026 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 465515002027 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 465515002028 Tubby C 2; Region: Tub_2; cl02043 465515002029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465515002030 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 465515002031 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 465515002032 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 465515002033 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 465515002034 ATP binding site [chemical binding]; other site 465515002035 Walker A motif; other site 465515002036 hexamer interface [polypeptide binding]; other site 465515002037 Walker B motif; other site 465515002038 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 465515002039 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 465515002040 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 465515002041 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 465515002042 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 465515002043 peptide chain release factor 2; Validated; Region: prfB; PRK00578 465515002044 PCRF domain; Region: PCRF; pfam03462 465515002045 RF-1 domain; Region: RF-1; pfam00472 465515002046 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 465515002047 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 465515002048 putative NAD(P) binding site [chemical binding]; other site 465515002049 catalytic Zn binding site [ion binding]; other site 465515002050 putative acyltransferase; Provisional; Region: PRK05790 465515002051 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 465515002052 dimer interface [polypeptide binding]; other site 465515002053 active site 465515002054 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 465515002055 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 465515002056 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 465515002057 SmpB-tmRNA interface; other site 465515002058 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 465515002059 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 465515002060 active site 465515002061 Predicted GTPases [General function prediction only]; Region: COG1162 465515002062 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 465515002063 GTPase/Zn-binding domain interface [polypeptide binding]; other site 465515002064 GTP/Mg2+ binding site [chemical binding]; other site 465515002065 G4 box; other site 465515002066 G5 box; other site 465515002067 G1 box; other site 465515002068 Switch I region; other site 465515002069 G2 box; other site 465515002070 G3 box; other site 465515002071 Switch II region; other site 465515002072 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 465515002073 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 465515002074 putative active site [active] 465515002075 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 465515002076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465515002077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465515002078 DNA binding residues [nucleotide binding] 465515002079 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 465515002080 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 465515002081 active site 465515002082 catalytic triad [active] 465515002083 oxyanion hole [active] 465515002084 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 465515002085 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 465515002086 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 465515002087 TPP-binding site [chemical binding]; other site 465515002088 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 465515002089 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 465515002090 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 465515002091 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 465515002092 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 465515002093 active site 465515002094 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 465515002095 Domain of unknown function DUF21; Region: DUF21; pfam01595 465515002096 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 465515002097 Transporter associated domain; Region: CorC_HlyC; smart01091 465515002098 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 465515002099 Domain of unknown function DUF21; Region: DUF21; pfam01595 465515002100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 465515002101 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 465515002102 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 465515002103 intersubunit interface [polypeptide binding]; other site 465515002104 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 465515002105 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465515002106 ABC-ATPase subunit interface; other site 465515002107 dimer interface [polypeptide binding]; other site 465515002108 putative PBP binding regions; other site 465515002109 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 465515002110 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 465515002111 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 465515002112 metal binding site 2 [ion binding]; metal-binding site 465515002113 putative DNA binding helix; other site 465515002114 metal binding site 1 [ion binding]; metal-binding site 465515002115 dimer interface [polypeptide binding]; other site 465515002116 structural Zn2+ binding site [ion binding]; other site 465515002117 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 465515002118 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 465515002119 active site residue [active] 465515002120 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 465515002121 active site residue [active] 465515002122 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 465515002123 nucleotide binding site/active site [active] 465515002124 HIT family signature motif; other site 465515002125 catalytic residue [active] 465515002126 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 465515002127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515002128 ATP binding site [chemical binding]; other site 465515002129 putative Mg++ binding site [ion binding]; other site 465515002130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 465515002131 nucleotide binding region [chemical binding]; other site 465515002132 ATP-binding site [chemical binding]; other site 465515002133 Helicase associated domain (HA2); Region: HA2; pfam04408 465515002134 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 465515002135 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 465515002136 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 465515002137 Na binding site [ion binding]; other site 465515002138 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 465515002139 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 465515002140 NAD(P) binding site [chemical binding]; other site 465515002141 catalytic residues [active] 465515002142 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 465515002143 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465515002144 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 465515002145 Walker A/P-loop; other site 465515002146 ATP binding site [chemical binding]; other site 465515002147 Q-loop/lid; other site 465515002148 ABC transporter signature motif; other site 465515002149 Walker B; other site 465515002150 D-loop; other site 465515002151 H-loop/switch region; other site 465515002152 ThiC-associated domain; Region: ThiC-associated; pfam13667 465515002153 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 465515002154 ThiC family; Region: ThiC; pfam01964 465515002155 Uncharacterized membrane protein [Function unknown]; Region: COG3949 465515002156 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 465515002157 dimer interface [polypeptide binding]; other site 465515002158 substrate binding site [chemical binding]; other site 465515002159 ATP binding site [chemical binding]; other site 465515002160 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 465515002161 active site 465515002162 thiamine phosphate binding site [chemical binding]; other site 465515002163 pyrophosphate binding site [ion binding]; other site 465515002164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515002165 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 465515002166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515002167 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 465515002168 thiS-thiF/thiG interaction site; other site 465515002169 thiazole synthase; Reviewed; Region: thiG; PRK00208 465515002170 phosphate binding site [ion binding]; other site 465515002171 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 465515002172 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 465515002173 ATP binding site [chemical binding]; other site 465515002174 substrate interface [chemical binding]; other site 465515002175 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 465515002176 active site residue [active] 465515002177 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 465515002178 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 465515002179 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 465515002180 active site 465515002181 HIGH motif; other site 465515002182 KMSK motif region; other site 465515002183 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 465515002184 tRNA binding surface [nucleotide binding]; other site 465515002185 anticodon binding site; other site 465515002186 diaminopimelate decarboxylase; Region: lysA; TIGR01048 465515002187 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 465515002188 active site 465515002189 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 465515002190 substrate binding site [chemical binding]; other site 465515002191 catalytic residues [active] 465515002192 dimer interface [polypeptide binding]; other site 465515002193 homoserine dehydrogenase; Provisional; Region: PRK06349 465515002194 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 465515002195 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 465515002196 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 465515002197 threonine synthase; Reviewed; Region: PRK06721 465515002198 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 465515002199 homodimer interface [polypeptide binding]; other site 465515002200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515002201 catalytic residue [active] 465515002202 homoserine kinase; Provisional; Region: PRK01212 465515002203 homoserine kinase; Provisional; Region: PRK01212 465515002204 transcription termination factor Rho; Provisional; Region: PRK12608 465515002205 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 465515002206 RNA binding site [nucleotide binding]; other site 465515002207 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 465515002208 multimer interface [polypeptide binding]; other site 465515002209 Walker A motif; other site 465515002210 ATP binding site [chemical binding]; other site 465515002211 Walker B motif; other site 465515002212 Protein chain release factor A [Translation, ribosomal structure and biogenesis]; Region: PrfA; COG0216 465515002213 This domain is found in peptide chain release factors; Region: PCRF; smart00937 465515002214 RF-1 domain; Region: RF-1; pfam00472 465515002215 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 465515002216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515002217 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 465515002218 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 465515002219 Mg++ binding site [ion binding]; other site 465515002220 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 465515002221 putative catalytic motif [active] 465515002222 substrate binding site [chemical binding]; other site 465515002223 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 465515002224 ATP synthase subunit C; Region: ATP-synt_C; cl00466 465515002225 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 465515002226 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 465515002227 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 465515002228 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 465515002229 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 465515002230 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 465515002231 beta subunit interaction interface [polypeptide binding]; other site 465515002232 Walker A motif; other site 465515002233 ATP binding site [chemical binding]; other site 465515002234 Walker B motif; other site 465515002235 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 465515002236 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 465515002237 core domain interface [polypeptide binding]; other site 465515002238 delta subunit interface [polypeptide binding]; other site 465515002239 epsilon subunit interface [polypeptide binding]; other site 465515002240 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 465515002241 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 465515002242 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 465515002243 alpha subunit interaction interface [polypeptide binding]; other site 465515002244 Walker A motif; other site 465515002245 ATP binding site [chemical binding]; other site 465515002246 Walker B motif; other site 465515002247 inhibitor binding site; inhibition site 465515002248 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 465515002249 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 465515002250 gamma subunit interface [polypeptide binding]; other site 465515002251 epsilon subunit interface [polypeptide binding]; other site 465515002252 LBP interface [polypeptide binding]; other site 465515002253 hypothetical protein; Provisional; Region: PRK03298 465515002254 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 465515002255 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 465515002256 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 465515002257 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 465515002258 Walker A/P-loop; other site 465515002259 ATP binding site [chemical binding]; other site 465515002260 Q-loop/lid; other site 465515002261 ABC transporter signature motif; other site 465515002262 Walker B; other site 465515002263 D-loop; other site 465515002264 H-loop/switch region; other site 465515002265 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 465515002266 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 465515002267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515002268 ATP binding site [chemical binding]; other site 465515002269 putative Mg++ binding site [ion binding]; other site 465515002270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465515002271 Coenzyme A binding pocket [chemical binding]; other site 465515002272 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 465515002273 catalytic triad [active] 465515002274 conserved cis-peptide bond; other site 465515002275 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 465515002276 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 465515002277 active site 465515002278 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 465515002279 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 465515002280 glutamate racemase; Provisional; Region: PRK00865 465515002281 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 465515002282 ribonuclease PH; Reviewed; Region: rph; PRK00173 465515002283 Ribonuclease PH; Region: RNase_PH_bact; cd11362 465515002284 hexamer interface [polypeptide binding]; other site 465515002285 active site 465515002286 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 465515002287 active site 465515002288 dimerization interface [polypeptide binding]; other site 465515002289 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 465515002290 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 465515002291 active site 465515002292 catalytic site [active] 465515002293 substrate binding site [chemical binding]; other site 465515002294 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 465515002295 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 465515002296 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 465515002297 active site 465515002298 metal binding site [ion binding]; metal-binding site 465515002299 DNA binding site [nucleotide binding] 465515002300 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 465515002301 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 465515002302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515002303 Walker A/P-loop; other site 465515002304 ATP binding site [chemical binding]; other site 465515002305 Q-loop/lid; other site 465515002306 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 465515002307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515002308 ABC transporter signature motif; other site 465515002309 Walker B; other site 465515002310 D-loop; other site 465515002311 H-loop/switch region; other site 465515002312 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 465515002313 Protein export membrane protein; Region: SecD_SecF; cl14618 465515002314 malate:quinone oxidoreductase; Validated; Region: PRK05257 465515002315 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 465515002316 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 465515002317 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 465515002318 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 465515002319 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 465515002320 catalytic triad [active] 465515002321 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 465515002322 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 465515002323 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 465515002324 active site 465515002325 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 465515002326 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 465515002327 PYR/PP interface [polypeptide binding]; other site 465515002328 dimer interface [polypeptide binding]; other site 465515002329 TPP binding site [chemical binding]; other site 465515002330 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465515002331 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 465515002332 TPP-binding site [chemical binding]; other site 465515002333 dimer interface [polypeptide binding]; other site 465515002334 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 465515002335 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 465515002336 putative valine binding site [chemical binding]; other site 465515002337 dimer interface [polypeptide binding]; other site 465515002338 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 465515002339 ketol-acid reductoisomerase; Provisional; Region: PRK05479 465515002340 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 465515002341 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 465515002342 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 465515002343 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 465515002344 ligand binding site [chemical binding]; other site 465515002345 NAD binding site [chemical binding]; other site 465515002346 dimerization interface [polypeptide binding]; other site 465515002347 catalytic site [active] 465515002348 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 465515002349 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 465515002350 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 465515002351 active site 465515002352 HIGH motif; other site 465515002353 KMSKS motif; other site 465515002354 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 465515002355 anticodon binding site; other site 465515002356 tRNA binding surface [nucleotide binding]; other site 465515002357 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 465515002358 tartrate dehydrogenase; Region: TTC; TIGR02089 465515002359 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 465515002360 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 465515002361 homodimer interface [polypeptide binding]; other site 465515002362 substrate-cofactor binding pocket; other site 465515002363 catalytic residue [active] 465515002364 carbon starvation protein A; Provisional; Region: PRK15015 465515002365 Carbon starvation protein CstA; Region: CstA; pfam02554 465515002366 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 465515002367 Protein of unknown function (DUF466); Region: DUF466; cl01082 465515002368 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 465515002369 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 465515002370 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 465515002371 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 465515002372 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 465515002373 active site 465515002374 HIGH motif; other site 465515002375 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 465515002376 active site 465515002377 KMSKS motif; other site 465515002378 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 465515002379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515002380 active site 465515002381 motif I; other site 465515002382 motif II; other site 465515002383 Dynamin family; Region: Dynamin_N; pfam00350 465515002384 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 465515002385 G1 box; other site 465515002386 GTP/Mg2+ binding site [chemical binding]; other site 465515002387 G2 box; other site 465515002388 Dynamin family; Region: Dynamin_N; pfam00350 465515002389 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 465515002390 G1 box; other site 465515002391 GTP/Mg2+ binding site [chemical binding]; other site 465515002392 G2 box; other site 465515002393 Switch I region; other site 465515002394 G3 box; other site 465515002395 Switch II region; other site 465515002396 G4 box; other site 465515002397 G5 box; other site 465515002398 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 465515002399 dimerization interface [polypeptide binding]; other site 465515002400 ATP binding site [chemical binding]; other site 465515002401 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 465515002402 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 465515002403 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 465515002404 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 465515002405 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 465515002406 Transcriptional regulator [Transcription]; Region: IclR; COG1414 465515002407 Bacterial transcriptional regulator; Region: IclR; pfam01614 465515002408 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 465515002409 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 465515002410 substrate binding site [chemical binding]; other site 465515002411 ligand binding site [chemical binding]; other site 465515002412 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 465515002413 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 465515002414 hypothetical protein; Provisional; Region: PRK14812 465515002415 substrate binding site [chemical binding]; other site 465515002416 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 465515002417 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 465515002418 hinge; other site 465515002419 active site 465515002420 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 465515002421 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 465515002422 putative acyl-acceptor binding pocket; other site 465515002423 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 465515002424 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 465515002425 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 465515002426 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 465515002427 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 465515002428 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 465515002429 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 465515002430 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 465515002431 DAK2 domain; Region: Dak2; cl03685 465515002432 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 465515002433 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 465515002434 ssDNA binding site; other site 465515002435 generic binding surface II; other site 465515002436 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515002437 ATP binding site [chemical binding]; other site 465515002438 putative Mg++ binding site [ion binding]; other site 465515002439 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 465515002440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515002441 S-adenosylmethionine binding site [chemical binding]; other site 465515002442 aminotransferase; Validated; Region: PRK07777 465515002443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465515002444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515002445 homodimer interface [polypeptide binding]; other site 465515002446 catalytic residue [active] 465515002447 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 465515002448 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 465515002449 active site 465515002450 (T/H)XGH motif; other site 465515002451 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 465515002452 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 465515002453 active site 465515002454 tetramer interface; other site 465515002455 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 465515002456 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 465515002457 ribonuclease III; Reviewed; Region: rnc; PRK00102 465515002458 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 465515002459 active site 465515002460 dimerization interface [polypeptide binding]; other site 465515002461 metal binding site [ion binding]; metal-binding site 465515002462 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 465515002463 dsRNA binding site [nucleotide binding]; other site 465515002464 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 465515002465 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 465515002466 DNA binding site [nucleotide binding] 465515002467 catalytic residue [active] 465515002468 H2TH interface [polypeptide binding]; other site 465515002469 putative catalytic residues [active] 465515002470 turnover-facilitating residue; other site 465515002471 intercalation triad [nucleotide binding]; other site 465515002472 8OG recognition residue [nucleotide binding]; other site 465515002473 putative reading head residues; other site 465515002474 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 465515002475 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 465515002476 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 465515002477 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 465515002478 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 465515002479 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465515002480 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465515002481 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515002482 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 465515002483 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 465515002484 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 465515002485 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 465515002486 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 465515002487 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 465515002488 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 465515002489 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 465515002490 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 465515002491 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 465515002492 putative trimer interface [polypeptide binding]; other site 465515002493 putative active site [active] 465515002494 putative substrate binding site [chemical binding]; other site 465515002495 putative CoA binding site [chemical binding]; other site 465515002496 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 465515002497 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 465515002498 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 465515002499 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465515002500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515002501 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515002502 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465515002503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465515002504 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 465515002505 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 465515002506 Walker A/P-loop; other site 465515002507 ATP binding site [chemical binding]; other site 465515002508 Q-loop/lid; other site 465515002509 ABC transporter signature motif; other site 465515002510 Walker B; other site 465515002511 D-loop; other site 465515002512 H-loop/switch region; other site 465515002513 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 465515002514 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 465515002515 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 465515002516 active site 465515002517 homodimer interface [polypeptide binding]; other site 465515002518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515002519 putative substrate translocation pore; other site 465515002520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465515002521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515002522 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515002523 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 465515002524 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 465515002525 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 465515002526 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 465515002527 signal recognition particle protein; Provisional; Region: PRK10867 465515002528 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 465515002529 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 465515002530 P loop; other site 465515002531 GTP binding site [chemical binding]; other site 465515002532 Signal peptide binding domain; Region: SRP_SPB; pfam02978 465515002533 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 465515002534 hypothetical protein; Provisional; Region: PRK02821 465515002535 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 465515002536 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 465515002537 RimM N-terminal domain; Region: RimM; pfam01782 465515002538 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 465515002539 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 465515002540 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 465515002541 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 465515002542 Catalytic site [active] 465515002543 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 465515002544 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 465515002545 Catalytic site [active] 465515002546 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 465515002547 RNA/DNA hybrid binding site [nucleotide binding]; other site 465515002548 active site 465515002549 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 465515002550 hypothetical protein; Reviewed; Region: PRK12497 465515002551 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 465515002552 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 465515002553 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 465515002554 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 465515002555 DNA protecting protein DprA; Region: dprA; TIGR00732 465515002556 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 465515002557 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 465515002558 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465515002559 active site 465515002560 DNA binding site [nucleotide binding] 465515002561 Int/Topo IB signature motif; other site 465515002562 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 465515002563 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 465515002564 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 465515002565 dimer interface [polypeptide binding]; other site 465515002566 active site 465515002567 acyl carrier protein; Provisional; Region: acpP; PRK00982 465515002568 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 465515002569 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 465515002570 dimer interface [polypeptide binding]; other site 465515002571 active site 465515002572 CoA binding pocket [chemical binding]; other site 465515002573 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 465515002574 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 465515002575 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 465515002576 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 465515002577 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 465515002578 dimer interface [polypeptide binding]; other site 465515002579 TPP-binding site [chemical binding]; other site 465515002580 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 465515002581 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 465515002582 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 465515002583 AzlC protein; Region: AzlC; cl00570 465515002584 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 465515002585 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 465515002586 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 465515002587 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 465515002588 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 465515002589 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 465515002590 serine O-acetyltransferase; Region: cysE; TIGR01172 465515002591 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 465515002592 trimer interface [polypeptide binding]; other site 465515002593 active site 465515002594 substrate binding site [chemical binding]; other site 465515002595 CoA binding site [chemical binding]; other site 465515002596 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 465515002597 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 465515002598 dimer interface [polypeptide binding]; other site 465515002599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515002600 catalytic residue [active] 465515002601 methionine sulfoxide reductase A; Provisional; Region: PRK14054 465515002602 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 465515002603 Uncharacterized conserved protein [Function unknown]; Region: COG0327 465515002604 Putative zinc ribbon domain; Region: DUF164; pfam02591 465515002605 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 465515002606 RNA/DNA hybrid binding site [nucleotide binding]; other site 465515002607 active site 465515002608 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 465515002609 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 465515002610 putative dimer interface [polypeptide binding]; other site 465515002611 ligand binding site [chemical binding]; other site 465515002612 Zn binding site [ion binding]; other site 465515002613 hypothetical protein; Validated; Region: PRK02101 465515002614 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 465515002615 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 465515002616 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 465515002617 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 465515002618 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 465515002619 inhibitor site; inhibition site 465515002620 active site 465515002621 dimer interface [polypeptide binding]; other site 465515002622 catalytic residue [active] 465515002623 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 465515002624 active site 465515002625 catalytic residues [active] 465515002626 metal binding site [ion binding]; metal-binding site 465515002627 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 465515002628 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 465515002629 ligand binding site [chemical binding]; other site 465515002630 flexible hinge region; other site 465515002631 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 465515002632 putative switch regulator; other site 465515002633 non-specific DNA interactions [nucleotide binding]; other site 465515002634 DNA binding site [nucleotide binding] 465515002635 sequence specific DNA binding site [nucleotide binding]; other site 465515002636 putative cAMP binding site [chemical binding]; other site 465515002637 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 465515002638 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 465515002639 metal-binding site [ion binding] 465515002640 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 465515002641 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 465515002642 Soluble P-type ATPase [General function prediction only]; Region: COG4087 465515002643 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 465515002644 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 465515002645 Domain of unknown function (DUF955); Region: DUF955; cl01076 465515002646 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 465515002647 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 465515002648 Int/Topo IB signature motif; other site 465515002649 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 465515002650 catalytic site [active] 465515002651 putative active site [active] 465515002652 putative substrate binding site [chemical binding]; other site 465515002653 dimer interface [polypeptide binding]; other site 465515002654 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 465515002655 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 465515002656 Predicted integral membrane protein [Function unknown]; Region: COG5650 465515002657 Predicted membrane protein [Function unknown]; Region: COG3463 465515002658 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 465515002659 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 465515002660 dimer interface [polypeptide binding]; other site 465515002661 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 465515002662 ssDNA binding site [nucleotide binding]; other site 465515002663 tetramer (dimer of dimers) interface [polypeptide binding]; other site 465515002664 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 465515002665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515002666 Walker A/P-loop; other site 465515002667 ATP binding site [chemical binding]; other site 465515002668 Q-loop/lid; other site 465515002669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465515002670 ABC transporter; Region: ABC_tran_2; pfam12848 465515002671 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465515002672 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 465515002673 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 465515002674 active site 465515002675 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 465515002676 catalytic triad [active] 465515002677 dimer interface [polypeptide binding]; other site 465515002678 OsmC-like protein; Region: OsmC; pfam02566 465515002679 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 465515002680 apolar tunnel; other site 465515002681 heme binding site [chemical binding]; other site 465515002682 dimerization interface [polypeptide binding]; other site 465515002683 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 465515002684 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 465515002685 Zn binding site [ion binding]; other site 465515002686 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 465515002687 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 465515002688 DNA binding site [nucleotide binding] 465515002689 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 465515002690 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 465515002691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515002692 active site 465515002693 trigger factor; Provisional; Region: tig; PRK01490 465515002694 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465515002695 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 465515002696 Clp protease; Region: CLP_protease; pfam00574 465515002697 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 465515002698 oligomer interface [polypeptide binding]; other site 465515002699 active site residues [active] 465515002700 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 465515002701 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 465515002702 oligomer interface [polypeptide binding]; other site 465515002703 active site residues [active] 465515002704 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 465515002705 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 465515002706 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 465515002707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515002708 Walker A motif; other site 465515002709 ATP binding site [chemical binding]; other site 465515002710 Walker B motif; other site 465515002711 arginine finger; other site 465515002712 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 465515002713 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 465515002714 Predicted membrane protein [Function unknown]; Region: COG4270 465515002715 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 465515002716 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465515002717 active site 465515002718 HIGH motif; other site 465515002719 nucleotide binding site [chemical binding]; other site 465515002720 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465515002721 active site 465515002722 KMSKS motif; other site 465515002723 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 465515002724 tRNA binding surface [nucleotide binding]; other site 465515002725 anticodon binding site; other site 465515002726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515002727 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 465515002728 NAD(P) binding site [chemical binding]; other site 465515002729 active site 465515002730 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 465515002731 active site 465515002732 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 465515002733 active site 465515002734 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 465515002735 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 465515002736 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 465515002737 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 465515002738 Active Sites [active] 465515002739 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 465515002740 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 465515002741 Active Sites [active] 465515002742 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 465515002743 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 465515002744 CysD dimerization site [polypeptide binding]; other site 465515002745 G1 box; other site 465515002746 putative GEF interaction site [polypeptide binding]; other site 465515002747 GTP/Mg2+ binding site [chemical binding]; other site 465515002748 Switch I region; other site 465515002749 G2 box; other site 465515002750 G3 box; other site 465515002751 Switch II region; other site 465515002752 G4 box; other site 465515002753 G5 box; other site 465515002754 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 465515002755 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 465515002756 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465515002757 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 465515002758 Walker A/P-loop; other site 465515002759 ATP binding site [chemical binding]; other site 465515002760 Q-loop/lid; other site 465515002761 ABC transporter signature motif; other site 465515002762 Walker B; other site 465515002763 D-loop; other site 465515002764 H-loop/switch region; other site 465515002765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515002766 dimer interface [polypeptide binding]; other site 465515002767 conserved gate region; other site 465515002768 putative PBP binding loops; other site 465515002769 ABC-ATPase subunit interface; other site 465515002770 siroheme synthase; Provisional; Region: cysG; PRK10637 465515002771 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 465515002772 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 465515002773 active site 465515002774 SAM binding site [chemical binding]; other site 465515002775 homodimer interface [polypeptide binding]; other site 465515002776 ferredoxin-NADP+ reductase; Region: PLN02852 465515002777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515002778 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 465515002779 TIGR03085 family protein; Region: TIGR03085 465515002780 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 465515002781 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 465515002782 HIGH motif; other site 465515002783 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 465515002784 active site 465515002785 KMSKS motif; other site 465515002786 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 465515002787 tRNA binding surface [nucleotide binding]; other site 465515002788 anticodon binding site; other site 465515002789 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 465515002790 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465515002791 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465515002792 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 465515002793 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 465515002794 active site 465515002795 multimer interface [polypeptide binding]; other site 465515002796 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 465515002797 putative active site [active] 465515002798 redox center [active] 465515002799 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 465515002800 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 465515002801 homodimer interface [polypeptide binding]; other site 465515002802 oligonucleotide binding site [chemical binding]; other site 465515002803 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 465515002804 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 465515002805 GTPase CgtA; Reviewed; Region: obgE; PRK12296 465515002806 GTP1/OBG; Region: GTP1_OBG; pfam01018 465515002807 Obg GTPase; Region: Obg; cd01898 465515002808 G1 box; other site 465515002809 GTP/Mg2+ binding site [chemical binding]; other site 465515002810 Switch I region; other site 465515002811 G2 box; other site 465515002812 G3 box; other site 465515002813 Switch II region; other site 465515002814 G4 box; other site 465515002815 G5 box; other site 465515002816 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 465515002817 gamma-glutamyl kinase; Provisional; Region: PRK05429 465515002818 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 465515002819 nucleotide binding site [chemical binding]; other site 465515002820 homotetrameric interface [polypeptide binding]; other site 465515002821 putative phosphate binding site [ion binding]; other site 465515002822 putative allosteric binding site; other site 465515002823 PUA domain; Region: PUA; pfam01472 465515002824 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 465515002825 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 465515002826 putative catalytic cysteine [active] 465515002827 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 465515002828 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 465515002829 active site 465515002830 (T/H)XGH motif; other site 465515002831 Oligomerisation domain; Region: Oligomerisation; pfam02410 465515002832 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465515002833 catalytic core [active] 465515002834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515002835 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 465515002836 Walker A motif; other site 465515002837 ATP binding site [chemical binding]; other site 465515002838 Walker B motif; other site 465515002839 arginine finger; other site 465515002840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515002841 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515002842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 465515002843 Transposase; Region: HTH_Tnp_1; cl17663 465515002844 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515002845 MULE transposase domain; Region: MULE; pfam10551 465515002846 Integrase core domain; Region: rve; pfam00665 465515002847 Integrase core domain; Region: rve_3; cl15866 465515002848 putative oxidoreductase; Provisional; Region: PRK10206 465515002849 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 465515002850 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 465515002851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465515002852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515002853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 465515002854 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 465515002855 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 465515002856 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 465515002857 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 465515002858 NAD(P) binding site [chemical binding]; other site 465515002859 catalytic residues [active] 465515002860 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 465515002861 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465515002862 inhibitor-cofactor binding pocket; inhibition site 465515002863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515002864 catalytic residue [active] 465515002865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465515002866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465515002867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 465515002868 dimerization interface [polypeptide binding]; other site 465515002869 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 465515002870 active site 465515002871 putative catalytic site [active] 465515002872 Domain of unknown function (DUF305); Region: DUF305; cl17794 465515002873 Predicted acetyltransferase [General function prediction only]; Region: COG2388 465515002874 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515002875 MULE transposase domain; Region: MULE; pfam10551 465515002876 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515002877 MULE transposase domain; Region: MULE; pfam10551 465515002878 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 465515002879 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515002880 MULE transposase domain; Region: MULE; pfam10551 465515002881 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 465515002882 catalytic residues [active] 465515002883 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 465515002884 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 465515002885 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 465515002886 Class I ribonucleotide reductase; Region: RNR_I; cd01679 465515002887 active site 465515002888 dimer interface [polypeptide binding]; other site 465515002889 catalytic residues [active] 465515002890 effector binding site; other site 465515002891 R2 peptide binding site; other site 465515002892 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 465515002893 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 465515002894 dimer interface [polypeptide binding]; other site 465515002895 putative radical transfer pathway; other site 465515002896 diiron center [ion binding]; other site 465515002897 tyrosyl radical; other site 465515002898 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 465515002899 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 465515002900 Walker A/P-loop; other site 465515002901 ATP binding site [chemical binding]; other site 465515002902 Q-loop/lid; other site 465515002903 ABC transporter signature motif; other site 465515002904 Walker B; other site 465515002905 D-loop; other site 465515002906 H-loop/switch region; other site 465515002907 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 465515002908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515002909 dimer interface [polypeptide binding]; other site 465515002910 conserved gate region; other site 465515002911 ABC-ATPase subunit interface; other site 465515002912 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 465515002913 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 465515002914 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 465515002915 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 465515002916 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 465515002917 active site 465515002918 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 465515002919 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 465515002920 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 465515002921 NAD binding site [chemical binding]; other site 465515002922 catalytic Zn binding site [ion binding]; other site 465515002923 substrate binding site [chemical binding]; other site 465515002924 structural Zn binding site [ion binding]; other site 465515002925 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 465515002926 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 465515002927 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 465515002928 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 465515002929 active site 465515002930 PHP Thumb interface [polypeptide binding]; other site 465515002931 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 465515002932 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 465515002933 generic binding surface II; other site 465515002934 generic binding surface I; other site 465515002935 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 465515002936 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 465515002937 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 465515002938 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 465515002939 active site 465515002940 dimer interface [polypeptide binding]; other site 465515002941 motif 1; other site 465515002942 motif 2; other site 465515002943 motif 3; other site 465515002944 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 465515002945 anticodon binding site; other site 465515002946 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 465515002947 nucleotide binding site/active site [active] 465515002948 HIT family signature motif; other site 465515002949 catalytic residue [active] 465515002950 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 465515002951 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 465515002952 putative deacylase active site [active] 465515002953 Fe-S metabolism associated domain; Region: SufE; cl00951 465515002954 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 465515002955 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 465515002956 active site residue [active] 465515002957 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 465515002958 active site residue [active] 465515002959 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 465515002960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 465515002961 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 465515002962 active site 465515002963 catalytic residues [active] 465515002964 metal binding site [ion binding]; metal-binding site 465515002965 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 465515002966 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 465515002967 putative active site [active] 465515002968 substrate binding site [chemical binding]; other site 465515002969 putative cosubstrate binding site; other site 465515002970 catalytic site [active] 465515002971 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 465515002972 substrate binding site [chemical binding]; other site 465515002973 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 465515002974 putative RNA binding site [nucleotide binding]; other site 465515002975 16S rRNA methyltransferase B; Provisional; Region: PRK14902 465515002976 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 465515002977 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 465515002978 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 465515002979 substrate binding site [chemical binding]; other site 465515002980 hexamer interface [polypeptide binding]; other site 465515002981 metal binding site [ion binding]; metal-binding site 465515002982 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 465515002983 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 465515002984 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 465515002985 catalytic motif [active] 465515002986 Zn binding site [ion binding]; other site 465515002987 RibD C-terminal domain; Region: RibD_C; pfam01872 465515002988 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 465515002989 Lumazine binding domain; Region: Lum_binding; pfam00677 465515002990 Lumazine binding domain; Region: Lum_binding; pfam00677 465515002991 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 465515002992 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 465515002993 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 465515002994 dimerization interface [polypeptide binding]; other site 465515002995 active site 465515002996 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 465515002997 homopentamer interface [polypeptide binding]; other site 465515002998 active site 465515002999 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 465515003000 metal binding site [ion binding]; metal-binding site 465515003001 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 465515003002 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 465515003003 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 465515003004 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 465515003005 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 465515003006 substrate binding site [chemical binding]; other site 465515003007 glutamase interaction surface [polypeptide binding]; other site 465515003008 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 465515003009 anthranilate synthase component I; Provisional; Region: PRK13571 465515003010 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 465515003011 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 465515003012 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 465515003013 active site 465515003014 ribulose/triose binding site [chemical binding]; other site 465515003015 phosphate binding site [ion binding]; other site 465515003016 substrate (anthranilate) binding pocket [chemical binding]; other site 465515003017 product (indole) binding pocket [chemical binding]; other site 465515003018 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 465515003019 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 465515003020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515003021 catalytic residue [active] 465515003022 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 465515003023 substrate binding site [chemical binding]; other site 465515003024 active site 465515003025 catalytic residues [active] 465515003026 heterodimer interface [polypeptide binding]; other site 465515003027 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 465515003028 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 465515003029 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 465515003030 active site 465515003031 dimer interface [polypeptide binding]; other site 465515003032 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 465515003033 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 465515003034 active site 465515003035 FMN binding site [chemical binding]; other site 465515003036 substrate binding site [chemical binding]; other site 465515003037 3Fe-4S cluster binding site [ion binding]; other site 465515003038 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 465515003039 domain interface; other site 465515003040 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 465515003041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515003042 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 465515003043 pyruvate kinase; Provisional; Region: PRK06247 465515003044 domain interfaces; other site 465515003045 active site 465515003046 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 465515003047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515003048 active site 465515003049 phosphorylation site [posttranslational modification] 465515003050 intermolecular recognition site; other site 465515003051 dimerization interface [polypeptide binding]; other site 465515003052 ANTAR domain; Region: ANTAR; pfam03861 465515003053 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 465515003054 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 465515003055 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 465515003056 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 465515003057 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 465515003058 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 465515003059 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 465515003060 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 465515003061 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 465515003062 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 465515003063 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 465515003064 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 465515003065 CoenzymeA binding site [chemical binding]; other site 465515003066 subunit interaction site [polypeptide binding]; other site 465515003067 PHB binding site; other site 465515003068 DNA polymerase I; Provisional; Region: PRK05755 465515003069 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 465515003070 active site 465515003071 metal binding site 1 [ion binding]; metal-binding site 465515003072 putative 5' ssDNA interaction site; other site 465515003073 metal binding site 3; metal-binding site 465515003074 metal binding site 2 [ion binding]; metal-binding site 465515003075 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 465515003076 putative DNA binding site [nucleotide binding]; other site 465515003077 putative metal binding site [ion binding]; other site 465515003078 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 465515003079 active site 465515003080 substrate binding site [chemical binding]; other site 465515003081 catalytic site [active] 465515003082 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 465515003083 active site 465515003084 DNA binding site [nucleotide binding] 465515003085 catalytic site [active] 465515003086 hypothetical protein; Provisional; Region: PRK01346 465515003087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465515003088 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 465515003089 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 465515003090 RNA binding site [nucleotide binding]; other site 465515003091 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 465515003092 RNA binding site [nucleotide binding]; other site 465515003093 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 465515003094 RNA binding site [nucleotide binding]; other site 465515003095 S1 RNA binding domain; Region: S1; pfam00575 465515003096 RNA binding site [nucleotide binding]; other site 465515003097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 465515003098 Uncharacterized conserved protein [Function unknown]; Region: COG1739 465515003099 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 465515003100 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 465515003101 BCCT family transporter; Region: BCCT; pfam02028 465515003102 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 465515003103 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 465515003104 CoA-binding site [chemical binding]; other site 465515003105 ATP-binding [chemical binding]; other site 465515003106 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 465515003107 CoA-binding site [chemical binding]; other site 465515003108 ATP-binding [chemical binding]; other site 465515003109 excinuclease ABC subunit B; Provisional; Region: PRK05298 465515003110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515003111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515003112 nucleotide binding region [chemical binding]; other site 465515003113 ATP-binding site [chemical binding]; other site 465515003114 Ultra-violet resistance protein B; Region: UvrB; pfam12344 465515003115 UvrB/uvrC motif; Region: UVR; pfam02151 465515003116 Integral membrane protein TerC family; Region: TerC; cl10468 465515003117 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 465515003118 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 465515003119 DEAD-like helicases superfamily; Region: DEXDc; smart00487 465515003120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 465515003121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515003122 ATP binding site [chemical binding]; other site 465515003123 putative Mg++ binding site [ion binding]; other site 465515003124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515003125 nucleotide binding region [chemical binding]; other site 465515003126 ATP-binding site [chemical binding]; other site 465515003127 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 465515003128 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 465515003129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515003130 S-adenosylmethionine binding site [chemical binding]; other site 465515003131 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 465515003132 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 465515003133 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 465515003134 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 465515003135 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 465515003136 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 465515003137 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 465515003138 putative acyl-acceptor binding pocket; other site 465515003139 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 465515003140 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 465515003141 GIY-YIG motif/motif A; other site 465515003142 active site 465515003143 catalytic site [active] 465515003144 putative DNA binding site [nucleotide binding]; other site 465515003145 metal binding site [ion binding]; metal-binding site 465515003146 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 465515003147 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 465515003148 DNA binding site [nucleotide binding] 465515003149 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 465515003150 AAA domain; Region: AAA_18; pfam13238 465515003151 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 465515003152 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 465515003153 putative substrate binding pocket [chemical binding]; other site 465515003154 dimer interface [polypeptide binding]; other site 465515003155 phosphate binding site [ion binding]; other site 465515003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 465515003157 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 465515003158 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 465515003159 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 465515003160 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 465515003161 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 465515003162 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 465515003163 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 465515003164 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 465515003165 Phosphoglycerate kinase; Region: PGK; pfam00162 465515003166 substrate binding site [chemical binding]; other site 465515003167 hinge regions; other site 465515003168 ADP binding site [chemical binding]; other site 465515003169 catalytic site [active] 465515003170 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 465515003171 triosephosphate isomerase; Provisional; Region: PRK14567 465515003172 substrate binding site [chemical binding]; other site 465515003173 dimer interface [polypeptide binding]; other site 465515003174 catalytic triad [active] 465515003175 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 465515003176 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 465515003177 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 465515003178 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 465515003179 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 465515003180 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 465515003181 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 465515003182 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 465515003183 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 465515003184 putative active site [active] 465515003185 transaldolase; Provisional; Region: PRK03903 465515003186 catalytic residue [active] 465515003187 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 465515003188 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 465515003189 TPP-binding site [chemical binding]; other site 465515003190 dimer interface [polypeptide binding]; other site 465515003191 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 465515003192 PYR/PP interface [polypeptide binding]; other site 465515003193 dimer interface [polypeptide binding]; other site 465515003194 TPP binding site [chemical binding]; other site 465515003195 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 465515003196 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 465515003197 UbiA prenyltransferase family; Region: UbiA; pfam01040 465515003198 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 465515003199 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 465515003200 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 465515003201 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 465515003202 Walker A/P-loop; other site 465515003203 ATP binding site [chemical binding]; other site 465515003204 Q-loop/lid; other site 465515003205 ABC transporter signature motif; other site 465515003206 Walker B; other site 465515003207 D-loop; other site 465515003208 H-loop/switch region; other site 465515003209 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 465515003210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465515003211 putative DNA binding site [nucleotide binding]; other site 465515003212 putative Zn2+ binding site [ion binding]; other site 465515003213 FeS assembly protein SufB; Region: sufB; TIGR01980 465515003214 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 465515003215 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 465515003216 FeS assembly protein SufD; Region: sufD; TIGR01981 465515003217 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 465515003218 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 465515003219 Walker A/P-loop; other site 465515003220 ATP binding site [chemical binding]; other site 465515003221 Q-loop/lid; other site 465515003222 ABC transporter signature motif; other site 465515003223 Walker B; other site 465515003224 D-loop; other site 465515003225 H-loop/switch region; other site 465515003226 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 465515003227 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 465515003228 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 465515003229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515003230 Walker A/P-loop; other site 465515003231 ATP binding site [chemical binding]; other site 465515003232 Q-loop/lid; other site 465515003233 ABC transporter signature motif; other site 465515003234 Walker B; other site 465515003235 D-loop; other site 465515003236 H-loop/switch region; other site 465515003237 ABC transporter; Region: ABC_tran_2; pfam12848 465515003238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465515003239 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 465515003240 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 465515003241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515003242 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 465515003243 NAD(P) binding site [chemical binding]; other site 465515003244 active site 465515003245 short chain dehydrogenase; Provisional; Region: PRK07806 465515003246 NAD(P) binding site [chemical binding]; other site 465515003247 active site 465515003248 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 465515003249 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 465515003250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515003251 motif II; other site 465515003252 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 465515003253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515003254 Walker A/P-loop; other site 465515003255 ATP binding site [chemical binding]; other site 465515003256 ABC transporter signature motif; other site 465515003257 Walker B; other site 465515003258 D-loop; other site 465515003259 H-loop/switch region; other site 465515003260 hypothetical protein; Provisional; Region: PRK10621 465515003261 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 465515003262 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 465515003263 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 465515003264 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 465515003265 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 465515003266 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 465515003267 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 465515003268 Zn binding site [ion binding]; other site 465515003269 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 465515003270 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 465515003271 ligand binding site; other site 465515003272 oligomer interface; other site 465515003273 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 465515003274 dimer interface [polypeptide binding]; other site 465515003275 N-terminal domain interface [polypeptide binding]; other site 465515003276 sulfate 1 binding site; other site 465515003277 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 465515003278 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 465515003279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515003280 active site 465515003281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465515003282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515003283 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 465515003284 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 465515003285 dimer interface [polypeptide binding]; other site 465515003286 active site 465515003287 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 465515003288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515003289 NAD(P) binding site [chemical binding]; other site 465515003290 active site 465515003291 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465515003292 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465515003293 active site 2 [active] 465515003294 active site 1 [active] 465515003295 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 465515003296 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 465515003297 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 465515003298 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 465515003299 putative ADP-binding pocket [chemical binding]; other site 465515003300 hypothetical protein; Provisional; Region: PRK07906 465515003301 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 465515003302 putative metal binding site [ion binding]; other site 465515003303 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 465515003304 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465515003305 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 465515003306 active site 465515003307 HIGH motif; other site 465515003308 nucleotide binding site [chemical binding]; other site 465515003309 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465515003310 active site 465515003311 KMSKS motif; other site 465515003312 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 465515003313 tRNA binding surface [nucleotide binding]; other site 465515003314 anticodon binding site; other site 465515003315 PAC2 family; Region: PAC2; pfam09754 465515003316 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 465515003317 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 465515003318 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 465515003319 active site 465515003320 putative substrate binding region [chemical binding]; other site 465515003321 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 465515003322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 465515003323 proteasome ATPase; Region: pup_AAA; TIGR03689 465515003324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515003325 Walker A motif; other site 465515003326 ATP binding site [chemical binding]; other site 465515003327 Walker B motif; other site 465515003328 arginine finger; other site 465515003329 Pup-ligase protein; Region: Pup_ligase; pfam03136 465515003330 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 465515003331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515003332 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515003333 Pup-like protein; Region: Pup; pfam05639 465515003334 Pup-ligase protein; Region: Pup_ligase; cl15463 465515003335 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465515003336 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465515003337 WYL domain; Region: WYL; pfam13280 465515003338 Predicted transcriptional regulator [Transcription]; Region: COG2378 465515003339 WYL domain; Region: WYL; pfam13280 465515003340 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 465515003341 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 465515003342 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 465515003343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515003344 ATP binding site [chemical binding]; other site 465515003345 putative Mg++ binding site [ion binding]; other site 465515003346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515003347 nucleotide binding region [chemical binding]; other site 465515003348 ATP-binding site [chemical binding]; other site 465515003349 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 465515003350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 465515003351 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 465515003352 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 465515003353 Ligand binding site; other site 465515003354 Putative Catalytic site; other site 465515003355 DXD motif; other site 465515003356 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 465515003357 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 465515003358 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 465515003359 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 465515003360 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 465515003361 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 465515003362 phosphate binding site [ion binding]; other site 465515003363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515003364 glycogen branching enzyme; Provisional; Region: PRK14705 465515003365 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 465515003366 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515003367 MULE transposase domain; Region: MULE; pfam10551 465515003368 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 465515003369 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 465515003370 AsnC family; Region: AsnC_trans_reg; pfam01037 465515003371 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 465515003372 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 465515003373 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 465515003374 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 465515003375 Subunit I/III interface [polypeptide binding]; other site 465515003376 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 465515003377 Cytochrome c; Region: Cytochrom_C; pfam00034 465515003378 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 465515003379 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 465515003380 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 465515003381 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 465515003382 iron-sulfur cluster [ion binding]; other site 465515003383 [2Fe-2S] cluster binding site [ion binding]; other site 465515003384 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 465515003385 heme bH binding site [chemical binding]; other site 465515003386 Qi binding site; other site 465515003387 intrachain domain interface; other site 465515003388 heme bL binding site [chemical binding]; other site 465515003389 interchain domain interface [polypeptide binding]; other site 465515003390 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 465515003391 Qo binding site; other site 465515003392 Transposase; Region: DEDD_Tnp_IS110; pfam01548 465515003393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 465515003394 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 465515003395 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515003396 MULE transposase domain; Region: MULE; pfam10551 465515003397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 465515003398 Integrase core domain; Region: rve; pfam00665 465515003399 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 465515003400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515003401 Walker A motif; other site 465515003402 ATP binding site [chemical binding]; other site 465515003403 Walker B motif; other site 465515003404 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 465515003405 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 465515003406 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 465515003407 D-pathway; other site 465515003408 Putative ubiquinol binding site [chemical binding]; other site 465515003409 Low-spin heme (heme b) binding site [chemical binding]; other site 465515003410 Putative water exit pathway; other site 465515003411 Binuclear center (heme o3/CuB) [ion binding]; other site 465515003412 K-pathway; other site 465515003413 Putative proton exit pathway; other site 465515003414 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 465515003415 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 465515003416 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 465515003417 hypothetical protein; Provisional; Region: PRK07907 465515003418 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 465515003419 active site 465515003420 metal binding site [ion binding]; metal-binding site 465515003421 dimer interface [polypeptide binding]; other site 465515003422 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 465515003423 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 465515003424 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 465515003425 quinone interaction residues [chemical binding]; other site 465515003426 active site 465515003427 catalytic residues [active] 465515003428 FMN binding site [chemical binding]; other site 465515003429 substrate binding site [chemical binding]; other site 465515003430 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 465515003431 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 465515003432 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 465515003433 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 465515003434 catalytic residue [active] 465515003435 putative FPP diphosphate binding site; other site 465515003436 putative FPP binding hydrophobic cleft; other site 465515003437 dimer interface [polypeptide binding]; other site 465515003438 putative IPP diphosphate binding site; other site 465515003439 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 465515003440 Recombination protein O N terminal; Region: RecO_N; pfam11967 465515003441 Recombination protein O C terminal; Region: RecO_C; pfam02565 465515003442 2-isopropylmalate synthase; Validated; Region: PRK03739 465515003443 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 465515003444 active site 465515003445 catalytic residues [active] 465515003446 metal binding site [ion binding]; metal-binding site 465515003447 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 465515003448 GTPase Era; Reviewed; Region: era; PRK00089 465515003449 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 465515003450 G1 box; other site 465515003451 GTP/Mg2+ binding site [chemical binding]; other site 465515003452 Switch I region; other site 465515003453 G2 box; other site 465515003454 Switch II region; other site 465515003455 G3 box; other site 465515003456 G4 box; other site 465515003457 G5 box; other site 465515003458 KH domain; Region: KH_2; pfam07650 465515003459 FOG: CBS domain [General function prediction only]; Region: COG0517 465515003460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 465515003461 Transporter associated domain; Region: CorC_HlyC; smart01091 465515003462 metal-binding heat shock protein; Provisional; Region: PRK00016 465515003463 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 465515003464 PhoH-like protein; Region: PhoH; pfam02562 465515003465 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 465515003466 chaperone protein DnaJ; Provisional; Region: PRK14278 465515003467 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 465515003468 HSP70 interaction site [polypeptide binding]; other site 465515003469 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 465515003470 Zn binding sites [ion binding]; other site 465515003471 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 465515003472 dimer interface [polypeptide binding]; other site 465515003473 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 465515003474 HTH domain; Region: HTH_11; pfam08279 465515003475 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 465515003476 Tic20-like protein; Region: Tic20; pfam09685 465515003477 coproporphyrinogen III oxidase; Validated; Region: PRK05628 465515003478 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465515003479 FeS/SAM binding site; other site 465515003480 GTP-binding protein LepA; Provisional; Region: PRK05433 465515003481 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 465515003482 G1 box; other site 465515003483 putative GEF interaction site [polypeptide binding]; other site 465515003484 GTP/Mg2+ binding site [chemical binding]; other site 465515003485 Switch I region; other site 465515003486 G2 box; other site 465515003487 G3 box; other site 465515003488 Switch II region; other site 465515003489 G4 box; other site 465515003490 G5 box; other site 465515003491 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 465515003492 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 465515003493 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 465515003494 PemK-like protein; Region: PemK; cl00995 465515003495 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 465515003496 hypothetical protein; Reviewed; Region: PRK07914 465515003497 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 465515003498 Competence protein; Region: Competence; pfam03772 465515003499 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 465515003500 SLBB domain; Region: SLBB; pfam10531 465515003501 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 465515003502 Helix-hairpin-helix motif; Region: HHH; pfam00633 465515003503 EDD domain protein, DegV family; Region: DegV; TIGR00762 465515003504 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 465515003505 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 465515003506 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 465515003507 HIGH motif; other site 465515003508 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 465515003509 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465515003510 active site 465515003511 KMSKS motif; other site 465515003512 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 465515003513 tRNA binding surface [nucleotide binding]; other site 465515003514 anticodon binding site; other site 465515003515 Uncharacterized membrane protein [Function unknown]; Region: COG3949 465515003516 primosome assembly protein PriA; Provisional; Region: PRK14873 465515003517 S-adenosylmethionine synthetase; Validated; Region: PRK05250 465515003518 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 465515003519 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 465515003520 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 465515003521 Flavoprotein; Region: Flavoprotein; pfam02441 465515003522 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 465515003523 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 465515003524 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 465515003525 Guanylate kinase; Region: Guanylate_kin; pfam00625 465515003526 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 465515003527 catalytic site [active] 465515003528 G-X2-G-X-G-K; other site 465515003529 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 465515003530 active site 465515003531 dimer interface [polypeptide binding]; other site 465515003532 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 465515003533 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465515003534 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465515003535 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 465515003536 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465515003537 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465515003538 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 465515003539 IMP binding site; other site 465515003540 dimer interface [polypeptide binding]; other site 465515003541 interdomain contacts; other site 465515003542 partial ornithine binding site; other site 465515003543 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 465515003544 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 465515003545 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 465515003546 catalytic site [active] 465515003547 subunit interface [polypeptide binding]; other site 465515003548 dihydroorotase; Validated; Region: pyrC; PRK09357 465515003549 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 465515003550 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 465515003551 active site 465515003552 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 465515003553 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 465515003554 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 465515003555 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 465515003556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465515003557 active site 465515003558 transcription antitermination factor NusB; Region: nusB; TIGR01951 465515003559 putative RNA binding site [nucleotide binding]; other site 465515003560 elongation factor P; Validated; Region: PRK00529 465515003561 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 465515003562 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 465515003563 RNA binding site [nucleotide binding]; other site 465515003564 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 465515003565 RNA binding site [nucleotide binding]; other site 465515003566 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 465515003567 active site 465515003568 dimer interface [polypeptide binding]; other site 465515003569 metal binding site [ion binding]; metal-binding site 465515003570 shikimate kinase; Reviewed; Region: aroK; PRK00131 465515003571 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 465515003572 ADP binding site [chemical binding]; other site 465515003573 magnesium binding site [ion binding]; other site 465515003574 putative shikimate binding site; other site 465515003575 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 465515003576 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 465515003577 Tetramer interface [polypeptide binding]; other site 465515003578 active site 465515003579 FMN-binding site [chemical binding]; other site 465515003580 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 465515003581 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 465515003582 YceG-like family; Region: YceG; pfam02618 465515003583 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 465515003584 dimerization interface [polypeptide binding]; other site 465515003585 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 465515003586 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 465515003587 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 465515003588 motif 1; other site 465515003589 active site 465515003590 motif 2; other site 465515003591 motif 3; other site 465515003592 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 465515003593 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 465515003594 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 465515003595 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 465515003596 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465515003597 RNA binding surface [nucleotide binding]; other site 465515003598 recombination factor protein RarA; Reviewed; Region: PRK13342 465515003599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515003600 Walker A motif; other site 465515003601 ATP binding site [chemical binding]; other site 465515003602 Walker B motif; other site 465515003603 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 465515003604 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 465515003605 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 465515003606 putative active site [active] 465515003607 dimerization interface [polypeptide binding]; other site 465515003608 putative tRNAtyr binding site [nucleotide binding]; other site 465515003609 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 465515003610 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 465515003611 dimer interface [polypeptide binding]; other site 465515003612 anticodon binding site; other site 465515003613 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 465515003614 homodimer interface [polypeptide binding]; other site 465515003615 motif 1; other site 465515003616 active site 465515003617 motif 2; other site 465515003618 GAD domain; Region: GAD; pfam02938 465515003619 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 465515003620 active site 465515003621 motif 3; other site 465515003622 Amino acid permease; Region: AA_permease; pfam00324 465515003623 cationic amino acid transport permease; Region: 2A0303; TIGR00906 465515003624 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 465515003625 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 465515003626 dimer interface [polypeptide binding]; other site 465515003627 motif 1; other site 465515003628 active site 465515003629 motif 2; other site 465515003630 motif 3; other site 465515003631 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 465515003632 anticodon binding site; other site 465515003633 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 465515003634 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 465515003635 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 465515003636 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 465515003637 Zn2+ binding site [ion binding]; other site 465515003638 Mg2+ binding site [ion binding]; other site 465515003639 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 465515003640 synthetase active site [active] 465515003641 NTP binding site [chemical binding]; other site 465515003642 metal binding site [ion binding]; metal-binding site 465515003643 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 465515003644 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 465515003645 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 465515003646 Protein export membrane protein; Region: SecD_SecF; cl14618 465515003647 protein-export membrane protein SecD; Region: secD; TIGR01129 465515003648 Protein export membrane protein; Region: SecD_SecF; cl14618 465515003649 Preprotein translocase subunit; Region: YajC; pfam02699 465515003650 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 465515003651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515003652 Walker A motif; other site 465515003653 ATP binding site [chemical binding]; other site 465515003654 Walker B motif; other site 465515003655 arginine finger; other site 465515003656 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 465515003657 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 465515003658 RuvA N terminal domain; Region: RuvA_N; pfam01330 465515003659 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 465515003660 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 465515003661 active site 465515003662 putative DNA-binding cleft [nucleotide binding]; other site 465515003663 dimer interface [polypeptide binding]; other site 465515003664 hypothetical protein; Validated; Region: PRK00110 465515003665 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 465515003666 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 465515003667 Zn binding site [ion binding]; other site 465515003668 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 465515003669 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 465515003670 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 465515003671 SelR domain; Region: SelR; pfam01641 465515003672 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 465515003673 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 465515003674 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 465515003675 catalytic site [active] 465515003676 putative active site [active] 465515003677 putative substrate binding site [chemical binding]; other site 465515003678 HRDC domain; Region: HRDC; pfam00570 465515003679 fatty oxidation complex, alpha subunit FadJ; Region: FadJ; TIGR02440 465515003680 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465515003681 substrate binding site [chemical binding]; other site 465515003682 oxyanion hole (OAH) forming residues; other site 465515003683 trimer interface [polypeptide binding]; other site 465515003684 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 465515003685 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 465515003686 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 465515003687 iron-sulfur cluster [ion binding]; other site 465515003688 [2Fe-2S] cluster binding site [ion binding]; other site 465515003689 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 465515003690 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465515003691 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465515003692 active site 465515003693 catalytic tetrad [active] 465515003694 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 465515003695 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 465515003696 TPP-binding site [chemical binding]; other site 465515003697 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 465515003698 PYR/PP interface [polypeptide binding]; other site 465515003699 dimer interface [polypeptide binding]; other site 465515003700 TPP binding site [chemical binding]; other site 465515003701 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 465515003702 aconitate hydratase; Validated; Region: PRK09277 465515003703 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 465515003704 substrate binding site [chemical binding]; other site 465515003705 ligand binding site [chemical binding]; other site 465515003706 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 465515003707 substrate binding site [chemical binding]; other site 465515003708 TRAM domain; Region: TRAM; pfam01938 465515003709 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 465515003710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 465515003711 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 465515003712 TrkA-N domain; Region: TrkA_N; pfam02254 465515003713 TrkA-C domain; Region: TrkA_C; pfam02080 465515003714 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 465515003715 TrkA-N domain; Region: TrkA_N; pfam02254 465515003716 TrkA-C domain; Region: TrkA_C; pfam02080 465515003717 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 465515003718 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 465515003719 generic binding surface I; other site 465515003720 generic binding surface II; other site 465515003721 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 465515003722 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 465515003723 trimer interface [polypeptide binding]; other site 465515003724 active site 465515003725 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 465515003726 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 465515003727 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 465515003728 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 465515003729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 465515003730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465515003731 Coenzyme A binding pocket [chemical binding]; other site 465515003732 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 465515003733 CoA binding domain; Region: CoA_binding_2; pfam13380 465515003734 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 465515003735 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 465515003736 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 465515003737 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 465515003738 CAP-like domain; other site 465515003739 active site 465515003740 primary dimer interface [polypeptide binding]; other site 465515003741 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465515003742 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465515003743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465515003744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515003745 Walker A/P-loop; other site 465515003746 ATP binding site [chemical binding]; other site 465515003747 Q-loop/lid; other site 465515003748 ABC transporter signature motif; other site 465515003749 Walker B; other site 465515003750 D-loop; other site 465515003751 H-loop/switch region; other site 465515003752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515003753 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 465515003754 Walker A/P-loop; other site 465515003755 ATP binding site [chemical binding]; other site 465515003756 Q-loop/lid; other site 465515003757 ABC transporter signature motif; other site 465515003758 Walker B; other site 465515003759 D-loop; other site 465515003760 H-loop/switch region; other site 465515003761 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 465515003762 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 465515003763 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 465515003764 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 465515003765 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 465515003766 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 465515003767 active site 465515003768 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 465515003769 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515003770 peptide synthase; Provisional; Region: PRK09274 465515003771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515003772 acyl-activating enzyme (AAE) consensus motif; other site 465515003773 AMP binding site [chemical binding]; other site 465515003774 active site 465515003775 CoA binding site [chemical binding]; other site 465515003776 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 465515003777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515003778 NAD(P) binding site [chemical binding]; other site 465515003779 active site 465515003780 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 465515003781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515003782 ATP binding site [chemical binding]; other site 465515003783 Mg2+ binding site [ion binding]; other site 465515003784 G-X-G motif; other site 465515003785 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 465515003786 anchoring element; other site 465515003787 dimer interface [polypeptide binding]; other site 465515003788 ATP binding site [chemical binding]; other site 465515003789 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 465515003790 active site 465515003791 metal binding site [ion binding]; metal-binding site 465515003792 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 465515003793 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 465515003794 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 465515003795 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465515003796 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 465515003797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465515003798 DNA binding residues [nucleotide binding] 465515003799 PAC2 family; Region: PAC2; pfam09754 465515003800 multifunctional aminopeptidase A; Provisional; Region: PRK00913 465515003801 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 465515003802 interface (dimer of trimers) [polypeptide binding]; other site 465515003803 Substrate-binding/catalytic site; other site 465515003804 Zn-binding sites [ion binding]; other site 465515003805 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 465515003806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515003807 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 465515003808 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 465515003809 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465515003810 E3 interaction surface; other site 465515003811 lipoyl attachment site [posttranslational modification]; other site 465515003812 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465515003813 E3 interaction surface; other site 465515003814 lipoyl attachment site [posttranslational modification]; other site 465515003815 e3 binding domain; Region: E3_binding; pfam02817 465515003816 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 465515003817 Catalytic domain of Protein Kinases; Region: PKc; cd00180 465515003818 active site 465515003819 ATP binding site [chemical binding]; other site 465515003820 substrate binding site [chemical binding]; other site 465515003821 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 465515003822 lipoyl synthase; Provisional; Region: PRK05481 465515003823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465515003824 FeS/SAM binding site; other site 465515003825 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 465515003826 RDD family; Region: RDD; pfam06271 465515003827 glutamine synthetase, type I; Region: GlnA; TIGR00653 465515003828 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 465515003829 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 465515003830 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 465515003831 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 465515003832 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 465515003833 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 465515003834 metal binding triad; other site 465515003835 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 465515003836 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 465515003837 metal binding triad; other site 465515003838 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 465515003839 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 465515003840 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 465515003841 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 465515003842 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 465515003843 active site 465515003844 oligomerization interface [polypeptide binding]; other site 465515003845 metal binding site [ion binding]; metal-binding site 465515003846 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 465515003847 active site 465515003848 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 465515003849 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 465515003850 nucleotide binding site [chemical binding]; other site 465515003851 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 465515003852 ATP cone domain; Region: ATP-cone; pfam03477 465515003853 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 465515003854 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 465515003855 active site 465515003856 PHP Thumb interface [polypeptide binding]; other site 465515003857 metal binding site [ion binding]; metal-binding site 465515003858 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 465515003859 generic binding surface II; other site 465515003860 generic binding surface I; other site 465515003861 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 465515003862 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 465515003863 active site 465515003864 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 465515003865 DivIVA protein; Region: DivIVA; pfam05103 465515003866 DivIVA domain; Region: DivI1A_domain; TIGR03544 465515003867 Protein of unknown function (DUF552); Region: DUF552; pfam04472 465515003868 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 465515003869 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 465515003870 catalytic residue [active] 465515003871 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 465515003872 cell division protein FtsZ; Validated; Region: PRK09330 465515003873 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 465515003874 nucleotide binding site [chemical binding]; other site 465515003875 SulA interaction site; other site 465515003876 cell division protein FtsQ; Provisional; Region: PRK05529 465515003877 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 465515003878 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 465515003879 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 465515003880 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465515003881 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 465515003882 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 465515003883 active site 465515003884 homodimer interface [polypeptide binding]; other site 465515003885 cell division protein FtsW; Region: ftsW; TIGR02614 465515003886 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 465515003887 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465515003888 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465515003889 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 465515003890 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 465515003891 Mg++ binding site [ion binding]; other site 465515003892 putative catalytic motif [active] 465515003893 putative substrate binding site [chemical binding]; other site 465515003894 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 465515003895 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 465515003896 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465515003897 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465515003898 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 465515003899 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465515003900 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465515003901 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 465515003902 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 465515003903 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 465515003904 MraW methylase family; Region: Methyltransf_5; cl17771 465515003905 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 465515003906 cell division protein MraZ; Reviewed; Region: PRK00326 465515003907 MraZ protein; Region: MraZ; pfam02381 465515003908 MraZ protein; Region: MraZ; pfam02381 465515003909 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 465515003910 DNA polymerase IV; Validated; Region: PRK03858 465515003911 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 465515003912 active site 465515003913 DNA binding site [nucleotide binding] 465515003914 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 465515003915 substrate binding pocket [chemical binding]; other site 465515003916 chain length determination region; other site 465515003917 substrate-Mg2+ binding site; other site 465515003918 catalytic residues [active] 465515003919 aspartate-rich region 1; other site 465515003920 active site lid residues [active] 465515003921 aspartate-rich region 2; other site 465515003922 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515003923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515003924 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515003925 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 465515003926 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465515003927 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465515003928 catalytic residue [active] 465515003929 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 465515003930 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 465515003931 active site 465515003932 ATP binding site [chemical binding]; other site 465515003933 substrate binding site [chemical binding]; other site 465515003934 activation loop (A-loop); other site 465515003935 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 465515003936 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 465515003937 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 465515003938 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 465515003939 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 465515003940 putative acyl-acceptor binding pocket; other site 465515003941 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 465515003942 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 465515003943 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 465515003944 acyl-activating enzyme (AAE) consensus motif; other site 465515003945 putative AMP binding site [chemical binding]; other site 465515003946 putative active site [active] 465515003947 putative CoA binding site [chemical binding]; other site 465515003948 mycothione reductase; Reviewed; Region: PRK07846 465515003949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515003950 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 465515003951 pyruvate carboxylase; Reviewed; Region: PRK12999 465515003952 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465515003953 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465515003954 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 465515003955 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 465515003956 active site 465515003957 catalytic residues [active] 465515003958 metal binding site [ion binding]; metal-binding site 465515003959 homodimer binding site [polypeptide binding]; other site 465515003960 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 465515003961 carboxyltransferase (CT) interaction site; other site 465515003962 biotinylation site [posttranslational modification]; other site 465515003963 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 465515003964 DNA binding residues [nucleotide binding] 465515003965 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 465515003966 putative dimer interface [polypeptide binding]; other site 465515003967 Bifunctional nuclease; Region: DNase-RNase; cl00553 465515003968 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 465515003969 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 465515003970 DNA binding residues [nucleotide binding] 465515003971 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 465515003972 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 465515003973 phosphopeptide binding site; other site 465515003974 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 465515003975 lipoyl attachment site [posttranslational modification]; other site 465515003976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465515003977 active site 465515003978 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515003979 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515003980 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 465515003981 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465515003982 dimerization interface [polypeptide binding]; other site 465515003983 putative DNA binding site [nucleotide binding]; other site 465515003984 putative Zn2+ binding site [ion binding]; other site 465515003985 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 465515003986 Transposase; Region: HTH_Tnp_1; cl17663 465515003987 HTH-like domain; Region: HTH_21; pfam13276 465515003988 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515003989 MULE transposase domain; Region: MULE; pfam10551 465515003990 Integrase core domain; Region: rve; pfam00665 465515003991 Integrase core domain; Region: rve_3; cl15866 465515003992 GTP-binding protein Der; Reviewed; Region: PRK03003 465515003993 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 465515003994 G1 box; other site 465515003995 GTP/Mg2+ binding site [chemical binding]; other site 465515003996 Switch I region; other site 465515003997 G2 box; other site 465515003998 Switch II region; other site 465515003999 G3 box; other site 465515004000 G4 box; other site 465515004001 G5 box; other site 465515004002 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 465515004003 G1 box; other site 465515004004 GTP/Mg2+ binding site [chemical binding]; other site 465515004005 Switch I region; other site 465515004006 G2 box; other site 465515004007 G3 box; other site 465515004008 Switch II region; other site 465515004009 G4 box; other site 465515004010 G5 box; other site 465515004011 cytidylate kinase; Provisional; Region: cmk; PRK00023 465515004012 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 465515004013 CMP-binding site; other site 465515004014 The sites determining sugar specificity; other site 465515004015 prephenate dehydrogenase; Validated; Region: PRK06545 465515004016 prephenate dehydrogenase; Validated; Region: PRK08507 465515004017 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 465515004018 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 465515004019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465515004020 RNA binding surface [nucleotide binding]; other site 465515004021 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 465515004022 active site 465515004023 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 465515004024 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465515004025 P-loop; other site 465515004026 Magnesium ion binding site [ion binding]; other site 465515004027 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465515004028 Magnesium ion binding site [ion binding]; other site 465515004029 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 465515004030 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 465515004031 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 465515004032 PAS domain; Region: PAS_8; pfam13188 465515004033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515004034 ATP binding site [chemical binding]; other site 465515004035 G-X-G motif; other site 465515004036 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 465515004037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515004038 active site 465515004039 phosphorylation site [posttranslational modification] 465515004040 intermolecular recognition site; other site 465515004041 dimerization interface [polypeptide binding]; other site 465515004042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 465515004043 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 465515004044 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515004045 acyl-activating enzyme (AAE) consensus motif; other site 465515004046 AMP binding site [chemical binding]; other site 465515004047 active site 465515004048 CoA binding site [chemical binding]; other site 465515004049 Transcriptional regulators [Transcription]; Region: GntR; COG1802 465515004050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465515004051 DNA-binding site [nucleotide binding]; DNA binding site 465515004052 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 465515004053 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 465515004054 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 465515004055 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 465515004056 tetramer interface [polypeptide binding]; other site 465515004057 active site 465515004058 Mg2+/Mn2+ binding site [ion binding]; other site 465515004059 citrate synthase; Provisional; Region: PRK14033 465515004060 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 465515004061 oxalacetate binding site [chemical binding]; other site 465515004062 citrylCoA binding site [chemical binding]; other site 465515004063 coenzyme A binding site [chemical binding]; other site 465515004064 catalytic triad [active] 465515004065 CTP synthetase; Validated; Region: pyrG; PRK05380 465515004066 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 465515004067 Catalytic site [active] 465515004068 active site 465515004069 UTP binding site [chemical binding]; other site 465515004070 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 465515004071 active site 465515004072 putative oxyanion hole; other site 465515004073 catalytic triad [active] 465515004074 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 465515004075 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465515004076 active site 465515004077 DNA binding site [nucleotide binding] 465515004078 Int/Topo IB signature motif; other site 465515004079 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 465515004080 dimer interface [polypeptide binding]; other site 465515004081 ADP-ribose binding site [chemical binding]; other site 465515004082 active site 465515004083 nudix motif; other site 465515004084 metal binding site [ion binding]; metal-binding site 465515004085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515004086 Walker A/P-loop; other site 465515004087 ATP binding site [chemical binding]; other site 465515004088 Q-loop/lid; other site 465515004089 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 465515004090 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 465515004091 ABC transporter signature motif; other site 465515004092 Walker B; other site 465515004093 D-loop; other site 465515004094 H-loop/switch region; other site 465515004095 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 465515004096 ATP-NAD kinase; Region: NAD_kinase; pfam01513 465515004097 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 465515004098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465515004099 RNA binding surface [nucleotide binding]; other site 465515004100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515004101 S-adenosylmethionine binding site [chemical binding]; other site 465515004102 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 465515004103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515004104 motif II; other site 465515004105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515004106 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 465515004107 Winged helix-turn helix; Region: HTH_29; pfam13551 465515004108 Integrase core domain; Region: rve; pfam00665 465515004109 Integrase core domain; Region: rve_3; pfam13683 465515004110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515004111 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515004112 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 465515004113 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 465515004114 active site 465515004115 HIGH motif; other site 465515004116 dimer interface [polypeptide binding]; other site 465515004117 KMSKS motif; other site 465515004118 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465515004119 RNA binding surface [nucleotide binding]; other site 465515004120 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 465515004121 Part of AAA domain; Region: AAA_19; pfam13245 465515004122 Family description; Region: UvrD_C_2; pfam13538 465515004123 argininosuccinate lyase; Provisional; Region: PRK00855 465515004124 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 465515004125 active sites [active] 465515004126 tetramer interface [polypeptide binding]; other site 465515004127 argininosuccinate synthase; Provisional; Region: PRK13820 465515004128 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 465515004129 ANP binding site [chemical binding]; other site 465515004130 Substrate Binding Site II [chemical binding]; other site 465515004131 Substrate Binding Site I [chemical binding]; other site 465515004132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515004133 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515004134 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 465515004135 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515004136 arginine repressor; Provisional; Region: PRK03341 465515004137 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 465515004138 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 465515004139 ornithine carbamoyltransferase; Provisional; Region: PRK00779 465515004140 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 465515004141 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 465515004142 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 465515004143 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465515004144 inhibitor-cofactor binding pocket; inhibition site 465515004145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515004146 catalytic residue [active] 465515004147 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 465515004148 feedback inhibition sensing region; other site 465515004149 homohexameric interface [polypeptide binding]; other site 465515004150 nucleotide binding site [chemical binding]; other site 465515004151 N-acetyl-L-glutamate binding site [chemical binding]; other site 465515004152 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 465515004153 heterotetramer interface [polypeptide binding]; other site 465515004154 active site pocket [active] 465515004155 cleavage site 465515004156 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 465515004157 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 465515004158 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 465515004159 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 465515004160 NADP binding site [chemical binding]; other site 465515004161 dimer interface [polypeptide binding]; other site 465515004162 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 465515004163 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 465515004164 acyl-activating enzyme (AAE) consensus motif; other site 465515004165 AMP binding site [chemical binding]; other site 465515004166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 465515004167 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 465515004168 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 465515004169 putative CoA binding site [chemical binding]; other site 465515004170 putative trimer interface [polypeptide binding]; other site 465515004171 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 465515004172 putative trimer interface [polypeptide binding]; other site 465515004173 putative CoA binding site [chemical binding]; other site 465515004174 Peptidase family M1; Region: Peptidase_M1; pfam01433 465515004175 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 465515004176 Zn binding site [ion binding]; other site 465515004177 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 465515004178 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 465515004179 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 465515004180 putative tRNA-binding site [nucleotide binding]; other site 465515004181 B3/4 domain; Region: B3_4; pfam03483 465515004182 tRNA synthetase B5 domain; Region: B5; pfam03484 465515004183 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 465515004184 dimer interface [polypeptide binding]; other site 465515004185 motif 1; other site 465515004186 motif 3; other site 465515004187 motif 2; other site 465515004188 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 465515004189 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 465515004190 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 465515004191 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 465515004192 dimer interface [polypeptide binding]; other site 465515004193 motif 1; other site 465515004194 active site 465515004195 motif 2; other site 465515004196 motif 3; other site 465515004197 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 465515004198 CHY zinc finger; Region: zf-CHY; pfam05495 465515004199 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 465515004200 putative substrate binding pocket [chemical binding]; other site 465515004201 AC domain interface; other site 465515004202 catalytic triad [active] 465515004203 AB domain interface; other site 465515004204 Radical SAM superfamily; Region: Radical_SAM; pfam04055 465515004205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465515004206 FeS/SAM binding site; other site 465515004207 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 465515004208 active site 465515004209 8-oxo-dGMP binding site [chemical binding]; other site 465515004210 nudix motif; other site 465515004211 metal binding site [ion binding]; metal-binding site 465515004212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515004213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465515004214 putative substrate translocation pore; other site 465515004215 hypothetical protein; Provisional; Region: PRK04081 465515004216 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 465515004217 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 465515004218 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 465515004219 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 465515004220 23S rRNA binding site [nucleotide binding]; other site 465515004221 L21 binding site [polypeptide binding]; other site 465515004222 L13 binding site [polypeptide binding]; other site 465515004223 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 465515004224 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 465515004225 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 465515004226 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 465515004227 Transcription factor WhiB; Region: Whib; pfam02467 465515004228 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 465515004229 PAS fold; Region: PAS_4; pfam08448 465515004230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 465515004231 Histidine kinase; Region: HisKA_2; pfam07568 465515004232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515004233 ATP binding site [chemical binding]; other site 465515004234 G-X-G motif; other site 465515004235 AAA domain; Region: AAA_31; pfam13614 465515004236 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 465515004237 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 465515004238 Helix-turn-helix domain; Region: HTH_17; pfam12728 465515004239 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 465515004240 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 465515004241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 465515004242 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 465515004243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 465515004244 nucleotide binding region [chemical binding]; other site 465515004245 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 465515004246 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 465515004247 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515004248 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 465515004249 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 465515004250 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515004251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 465515004252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465515004253 dimerization interface [polypeptide binding]; other site 465515004254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465515004255 dimer interface [polypeptide binding]; other site 465515004256 phosphorylation site [posttranslational modification] 465515004257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515004258 ATP binding site [chemical binding]; other site 465515004259 Mg2+ binding site [ion binding]; other site 465515004260 G-X-G motif; other site 465515004261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465515004262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515004263 active site 465515004264 phosphorylation site [posttranslational modification] 465515004265 intermolecular recognition site; other site 465515004266 dimerization interface [polypeptide binding]; other site 465515004267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465515004268 DNA binding site [nucleotide binding] 465515004269 chorismate mutase; Provisional; Region: PRK09239 465515004270 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 465515004271 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 465515004272 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 465515004273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465515004274 catalytic residue [active] 465515004275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 465515004276 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515004277 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515004278 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 465515004279 TrkA-N domain; Region: TrkA_N; pfam02254 465515004280 TrkA-C domain; Region: TrkA_C; pfam02080 465515004281 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 465515004282 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 465515004283 dihydropteroate synthase; Region: DHPS; TIGR01496 465515004284 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 465515004285 substrate binding pocket [chemical binding]; other site 465515004286 dimer interface [polypeptide binding]; other site 465515004287 inhibitor binding site; inhibition site 465515004288 hypothetical protein; Provisional; Region: PRK14059 465515004289 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 465515004290 HSP70 interaction site [polypeptide binding]; other site 465515004291 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 465515004292 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 465515004293 Anti-sigma-K factor rskA; Region: RskA; pfam10099 465515004294 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 465515004295 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 465515004296 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515004297 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515004298 Repair protein; Region: Repair_PSII; pfam04536 465515004299 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 465515004300 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 465515004301 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 465515004302 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 465515004303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 465515004304 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515004305 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515004306 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 465515004307 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 465515004308 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 465515004309 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 465515004310 Protein of unknown function DUF45; Region: DUF45; cl00636 465515004311 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 465515004312 Part of AAA domain; Region: AAA_19; pfam13245 465515004313 Family description; Region: UvrD_C_2; pfam13538 465515004314 HRDC domain; Region: HRDC; pfam00570 465515004315 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 465515004316 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 465515004317 putative NADH binding site [chemical binding]; other site 465515004318 putative active site [active] 465515004319 nudix motif; other site 465515004320 putative metal binding site [ion binding]; other site 465515004321 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 465515004322 Phosphotransferase enzyme family; Region: APH; pfam01636 465515004323 active site 465515004324 ATP binding site [chemical binding]; other site 465515004325 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 465515004326 Part of AAA domain; Region: AAA_19; pfam13245 465515004327 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 465515004328 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 465515004329 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 465515004330 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 465515004331 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 465515004332 DNA binding site [nucleotide binding] 465515004333 active site 465515004334 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 465515004335 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 465515004336 active site 465515004337 catalytic site [active] 465515004338 substrate binding site [chemical binding]; other site 465515004339 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 465515004340 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465515004341 inhibitor-cofactor binding pocket; inhibition site 465515004342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515004343 catalytic residue [active] 465515004344 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 465515004345 dimer interface [polypeptide binding]; other site 465515004346 active site 465515004347 Schiff base residues; other site 465515004348 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 465515004349 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 465515004350 putative metal binding site [ion binding]; other site 465515004351 Uncharacterized conserved protein [Function unknown]; Region: COG1432 465515004352 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 465515004353 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 465515004354 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 465515004355 active site 465515004356 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 465515004357 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 465515004358 domain interfaces; other site 465515004359 active site 465515004360 ferrochelatase; Reviewed; Region: hemH; PRK00035 465515004361 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 465515004362 C-terminal domain interface [polypeptide binding]; other site 465515004363 active site 465515004364 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 465515004365 active site 465515004366 N-terminal domain interface [polypeptide binding]; other site 465515004367 Chlorite dismutase; Region: Chlor_dismutase; cl01280 465515004368 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 465515004369 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 465515004370 substrate binding site [chemical binding]; other site 465515004371 active site 465515004372 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 465515004373 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 465515004374 NAD(P) binding pocket [chemical binding]; other site 465515004375 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 465515004376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465515004377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515004378 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 465515004379 Exoribonuclease R [Transcription]; Region: VacB; COG0557 465515004380 RNB domain; Region: RNB; pfam00773 465515004381 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 465515004382 DEAD-like helicases superfamily; Region: DEXDc; smart00487 465515004383 ATP binding site [chemical binding]; other site 465515004384 Mg++ binding site [ion binding]; other site 465515004385 motif III; other site 465515004386 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515004387 nucleotide binding region [chemical binding]; other site 465515004388 ATP-binding site [chemical binding]; other site 465515004389 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 465515004390 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 465515004391 active site 465515004392 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 465515004393 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 465515004394 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 465515004395 active site 465515004396 pyruvate kinase; Provisional; Region: PRK14725 465515004397 active site 465515004398 MgtE intracellular N domain; Region: MgtE_N; smart00924 465515004399 FOG: CBS domain [General function prediction only]; Region: COG0517 465515004400 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 465515004401 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 465515004402 Domain of unknown function DUF59; Region: DUF59; pfam01883 465515004403 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 465515004404 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 465515004405 Putative zinc-finger; Region: zf-HC2; pfam13490 465515004406 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 465515004407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 465515004408 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 465515004409 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 465515004410 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 465515004411 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465515004412 Walker A/P-loop; other site 465515004413 ATP binding site [chemical binding]; other site 465515004414 Q-loop/lid; other site 465515004415 ABC transporter signature motif; other site 465515004416 Walker B; other site 465515004417 D-loop; other site 465515004418 H-loop/switch region; other site 465515004419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465515004420 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 465515004421 substrate binding pocket [chemical binding]; other site 465515004422 membrane-bound complex binding site; other site 465515004423 hinge residues; other site 465515004424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515004425 dimer interface [polypeptide binding]; other site 465515004426 conserved gate region; other site 465515004427 ABC-ATPase subunit interface; other site 465515004428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515004429 dimer interface [polypeptide binding]; other site 465515004430 conserved gate region; other site 465515004431 putative PBP binding loops; other site 465515004432 ABC-ATPase subunit interface; other site 465515004433 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 465515004434 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 465515004435 metal binding site [ion binding]; metal-binding site 465515004436 putative dimer interface [polypeptide binding]; other site 465515004437 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 465515004438 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 465515004439 putative trimer interface [polypeptide binding]; other site 465515004440 putative CoA binding site [chemical binding]; other site 465515004441 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 465515004442 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 465515004443 putative active site [active] 465515004444 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 465515004445 dimer interface [polypeptide binding]; other site 465515004446 Citrate synthase; Region: Citrate_synt; pfam00285 465515004447 active site 465515004448 citrylCoA binding site [chemical binding]; other site 465515004449 NADH binding [chemical binding]; other site 465515004450 cationic pore residues; other site 465515004451 oxalacetate/citrate binding site [chemical binding]; other site 465515004452 coenzyme A binding site [chemical binding]; other site 465515004453 catalytic triad [active] 465515004454 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 465515004455 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465515004456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515004457 homodimer interface [polypeptide binding]; other site 465515004458 catalytic residue [active] 465515004459 Ferredoxin [Energy production and conversion]; Region: COG1146 465515004460 4Fe-4S binding domain; Region: Fer4; pfam00037 465515004461 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 465515004462 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 465515004463 G1 box; other site 465515004464 putative GEF interaction site [polypeptide binding]; other site 465515004465 GTP/Mg2+ binding site [chemical binding]; other site 465515004466 Switch I region; other site 465515004467 G2 box; other site 465515004468 G3 box; other site 465515004469 Switch II region; other site 465515004470 G4 box; other site 465515004471 G5 box; other site 465515004472 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 465515004473 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 465515004474 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 465515004475 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465515004476 Walker A/P-loop; other site 465515004477 ATP binding site [chemical binding]; other site 465515004478 Q-loop/lid; other site 465515004479 ABC transporter signature motif; other site 465515004480 Walker B; other site 465515004481 D-loop; other site 465515004482 H-loop/switch region; other site 465515004483 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 465515004484 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465515004485 Walker A/P-loop; other site 465515004486 ATP binding site [chemical binding]; other site 465515004487 Q-loop/lid; other site 465515004488 ABC transporter signature motif; other site 465515004489 Walker B; other site 465515004490 D-loop; other site 465515004491 H-loop/switch region; other site 465515004492 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 465515004493 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 465515004494 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 465515004495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515004496 dimer interface [polypeptide binding]; other site 465515004497 conserved gate region; other site 465515004498 putative PBP binding loops; other site 465515004499 ABC-ATPase subunit interface; other site 465515004500 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 465515004501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 465515004502 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 465515004503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515004504 dimer interface [polypeptide binding]; other site 465515004505 ABC-ATPase subunit interface; other site 465515004506 putative PBP binding loops; other site 465515004507 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 465515004508 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 465515004509 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 465515004510 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 465515004511 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 465515004512 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 465515004513 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 465515004514 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 465515004515 dimer interface [polypeptide binding]; other site 465515004516 catalytic triad [active] 465515004517 peroxidatic and resolving cysteines [active] 465515004518 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 465515004519 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 465515004520 active site 465515004521 nucleophile elbow; other site 465515004522 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 465515004523 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 465515004524 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 465515004525 Ferritin-like domain; Region: Ferritin; pfam00210 465515004526 ferroxidase diiron center [ion binding]; other site 465515004527 Protein of unknown function (DUF808); Region: DUF808; cl01002 465515004528 acyl-CoA esterase; Provisional; Region: PRK10673 465515004529 PGAP1-like protein; Region: PGAP1; pfam07819 465515004530 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 465515004531 nudix motif; other site 465515004532 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 465515004533 quinolinate synthetase; Provisional; Region: PRK09375 465515004534 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 465515004535 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 465515004536 dimerization interface [polypeptide binding]; other site 465515004537 active site 465515004538 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 465515004539 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 465515004540 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465515004541 catalytic residue [active] 465515004542 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 465515004543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515004544 dimer interface [polypeptide binding]; other site 465515004545 conserved gate region; other site 465515004546 putative PBP binding loops; other site 465515004547 ABC-ATPase subunit interface; other site 465515004548 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 465515004549 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 465515004550 Walker A/P-loop; other site 465515004551 ATP binding site [chemical binding]; other site 465515004552 Q-loop/lid; other site 465515004553 ABC transporter signature motif; other site 465515004554 Walker B; other site 465515004555 D-loop; other site 465515004556 H-loop/switch region; other site 465515004557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515004558 dimer interface [polypeptide binding]; other site 465515004559 conserved gate region; other site 465515004560 putative PBP binding loops; other site 465515004561 ABC-ATPase subunit interface; other site 465515004562 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 465515004563 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 465515004564 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 465515004565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515004566 putative substrate translocation pore; other site 465515004567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515004568 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 465515004569 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 465515004570 active site 465515004571 DNA binding site [nucleotide binding] 465515004572 catalytic site [active] 465515004573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515004574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465515004575 putative substrate translocation pore; other site 465515004576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515004577 hypothetical protein; Provisional; Region: PRK09256 465515004578 Beta-lactamase; Region: Beta-lactamase; pfam00144 465515004579 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 465515004580 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 465515004581 heme-binding site [chemical binding]; other site 465515004582 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 465515004583 Cation efflux family; Region: Cation_efflux; pfam01545 465515004584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515004585 Uncharacterized conserved protein [Function unknown]; Region: COG3268 465515004586 NAD(P) binding site [chemical binding]; other site 465515004587 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 465515004588 ABC1 family; Region: ABC1; cl17513 465515004589 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 465515004590 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 465515004591 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 465515004592 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 465515004593 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 465515004594 Transcriptional regulators [Transcription]; Region: MarR; COG1846 465515004595 MarR family; Region: MarR_2; cl17246 465515004596 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 465515004597 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 465515004598 Prostaglandin dehydrogenases; Region: PGDH; cd05288 465515004599 NAD(P) binding site [chemical binding]; other site 465515004600 substrate binding site [chemical binding]; other site 465515004601 dimer interface [polypeptide binding]; other site 465515004602 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 465515004603 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 465515004604 potential catalytic triad [active] 465515004605 conserved cys residue [active] 465515004606 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 465515004607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515004608 Walker A/P-loop; other site 465515004609 ATP binding site [chemical binding]; other site 465515004610 Q-loop/lid; other site 465515004611 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465515004612 ABC transporter; Region: ABC_tran_2; pfam12848 465515004613 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465515004614 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 465515004615 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 465515004616 nucleophile elbow; other site 465515004617 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 465515004618 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 465515004619 amphipathic channel; other site 465515004620 Asn-Pro-Ala signature motifs; other site 465515004621 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465515004622 catalytic core [active] 465515004623 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 465515004624 conserved hypothetical protein; Region: TIGR03843 465515004625 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 465515004626 active site 465515004627 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 465515004628 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 465515004629 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515004630 MULE transposase domain; Region: MULE; pfam10551 465515004631 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515004632 MULE transposase domain; Region: MULE; pfam10551 465515004633 Uncharacterized conserved protein [Function unknown]; Region: COG1262 465515004634 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 465515004635 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 465515004636 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 465515004637 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 465515004638 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 465515004639 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 465515004640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515004641 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515004642 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515004643 MULE transposase domain; Region: MULE; pfam10551 465515004644 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 465515004645 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 465515004646 catalytic residues [active] 465515004647 catalytic nucleophile [active] 465515004648 Presynaptic Site I dimer interface [polypeptide binding]; other site 465515004649 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 465515004650 Synaptic Flat tetramer interface [polypeptide binding]; other site 465515004651 Synaptic Site I dimer interface [polypeptide binding]; other site 465515004652 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 465515004653 DNA-binding interface [nucleotide binding]; DNA binding site 465515004654 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 465515004655 GTP-binding protein YchF; Reviewed; Region: PRK09601 465515004656 YchF GTPase; Region: YchF; cd01900 465515004657 G1 box; other site 465515004658 GTP/Mg2+ binding site [chemical binding]; other site 465515004659 Switch I region; other site 465515004660 G2 box; other site 465515004661 Switch II region; other site 465515004662 G3 box; other site 465515004663 G4 box; other site 465515004664 G5 box; other site 465515004665 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 465515004666 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 465515004667 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 465515004668 putative dimer interface [polypeptide binding]; other site 465515004669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 465515004670 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 465515004671 Walker A/P-loop; other site 465515004672 ATP binding site [chemical binding]; other site 465515004673 Q-loop/lid; other site 465515004674 ABC transporter signature motif; other site 465515004675 Walker B; other site 465515004676 D-loop; other site 465515004677 H-loop/switch region; other site 465515004678 Histidine kinase; Region: HisKA_3; pfam07730 465515004679 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 465515004680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465515004681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515004682 active site 465515004683 phosphorylation site [posttranslational modification] 465515004684 intermolecular recognition site; other site 465515004685 dimerization interface [polypeptide binding]; other site 465515004686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465515004687 DNA binding residues [nucleotide binding] 465515004688 dimerization interface [polypeptide binding]; other site 465515004689 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 465515004690 putative ADP-ribose binding site [chemical binding]; other site 465515004691 putative active site [active] 465515004692 RmuC family; Region: RmuC; pfam02646 465515004693 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 465515004694 transmembrane helices; other site 465515004695 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 465515004696 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 465515004697 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 465515004698 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 465515004699 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 465515004700 generic binding surface II; other site 465515004701 generic binding surface I; other site 465515004702 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 465515004703 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 465515004704 intracellular protease, PfpI family; Region: PfpI; TIGR01382 465515004705 proposed catalytic triad [active] 465515004706 conserved cys residue [active] 465515004707 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 465515004708 aminotransferase AlaT; Validated; Region: PRK09265 465515004709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465515004710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515004711 homodimer interface [polypeptide binding]; other site 465515004712 catalytic residue [active] 465515004713 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 465515004714 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 465515004715 nudix motif; other site 465515004716 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 465515004717 substrate binding site [chemical binding]; other site 465515004718 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 465515004719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465515004720 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 465515004721 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 465515004722 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 465515004723 GMP synthase; Reviewed; Region: guaA; PRK00074 465515004724 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 465515004725 AMP/PPi binding site [chemical binding]; other site 465515004726 candidate oxyanion hole; other site 465515004727 catalytic triad [active] 465515004728 potential glutamine specificity residues [chemical binding]; other site 465515004729 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 465515004730 ATP Binding subdomain [chemical binding]; other site 465515004731 Ligand Binding sites [chemical binding]; other site 465515004732 Dimerization subdomain; other site 465515004733 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 465515004734 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 465515004735 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 465515004736 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 465515004737 phosphate binding site [ion binding]; other site 465515004738 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 465515004739 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 465515004740 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 465515004741 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 465515004742 active site 465515004743 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 465515004744 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 465515004745 BCCT family transporter; Region: BCCT; pfam02028 465515004746 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 465515004747 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 465515004748 ring oligomerisation interface [polypeptide binding]; other site 465515004749 ATP/Mg binding site [chemical binding]; other site 465515004750 stacking interactions; other site 465515004751 hinge regions; other site 465515004752 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 465515004753 oligomerisation interface [polypeptide binding]; other site 465515004754 mobile loop; other site 465515004755 roof hairpin; other site 465515004756 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 465515004757 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 465515004758 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 465515004759 Walker A/P-loop; other site 465515004760 ATP binding site [chemical binding]; other site 465515004761 Q-loop/lid; other site 465515004762 ABC transporter signature motif; other site 465515004763 Walker B; other site 465515004764 D-loop; other site 465515004765 H-loop/switch region; other site 465515004766 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465515004767 dimer interface [polypeptide binding]; other site 465515004768 putative PBP binding regions; other site 465515004769 ABC-ATPase subunit interface; other site 465515004770 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 465515004771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465515004772 ABC-ATPase subunit interface; other site 465515004773 dimer interface [polypeptide binding]; other site 465515004774 putative PBP binding regions; other site 465515004775 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 465515004776 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 465515004777 intersubunit interface [polypeptide binding]; other site 465515004778 carboxylate-amine ligase; Provisional; Region: PRK13517 465515004779 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 465515004780 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 465515004781 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 465515004782 NAD binding site [chemical binding]; other site 465515004783 catalytic Zn binding site [ion binding]; other site 465515004784 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 465515004785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515004786 NAD(P) binding site [chemical binding]; other site 465515004787 active site 465515004788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 465515004789 Cation efflux family; Region: Cation_efflux; pfam01545 465515004790 UGMP family protein; Validated; Region: PRK09604 465515004791 Fumble; Region: Fumble; cl17357 465515004792 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515004793 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 465515004794 Glycoprotease family; Region: Peptidase_M22; pfam00814 465515004795 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 465515004796 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 465515004797 alanine racemase; Reviewed; Region: alr; PRK00053 465515004798 active site 465515004799 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 465515004800 dimer interface [polypeptide binding]; other site 465515004801 substrate binding site [chemical binding]; other site 465515004802 catalytic residues [active] 465515004803 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 465515004804 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 465515004805 putative substrate binding site [chemical binding]; other site 465515004806 putative ATP binding site [chemical binding]; other site 465515004807 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 465515004808 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 465515004809 putative active site [active] 465515004810 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 465515004811 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 465515004812 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 465515004813 active site 465515004814 catalytic site [active] 465515004815 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 465515004816 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 465515004817 glutaminase active site [active] 465515004818 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 465515004819 dimer interface [polypeptide binding]; other site 465515004820 active site 465515004821 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 465515004822 dimer interface [polypeptide binding]; other site 465515004823 active site 465515004824 pantothenate kinase; Provisional; Region: PRK05439 465515004825 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 465515004826 ATP-binding site [chemical binding]; other site 465515004827 CoA-binding site [chemical binding]; other site 465515004828 Mg2+-binding site [ion binding]; other site 465515004829 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 465515004830 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 465515004831 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 465515004832 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 465515004833 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 465515004834 active site 465515004835 substrate binding site [chemical binding]; other site 465515004836 metal binding site [ion binding]; metal-binding site 465515004837 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 465515004838 amidase catalytic site [active] 465515004839 Zn binding residues [ion binding]; other site 465515004840 substrate binding site [chemical binding]; other site 465515004841 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 465515004842 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 465515004843 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 465515004844 23S rRNA interface [nucleotide binding]; other site 465515004845 L3 interface [polypeptide binding]; other site 465515004846 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 465515004847 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 465515004848 dimerization interface 3.5A [polypeptide binding]; other site 465515004849 active site 465515004850 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 465515004851 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 465515004852 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 465515004853 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 465515004854 alphaNTD homodimer interface [polypeptide binding]; other site 465515004855 alphaNTD - beta interaction site [polypeptide binding]; other site 465515004856 alphaNTD - beta' interaction site [polypeptide binding]; other site 465515004857 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 465515004858 30S ribosomal protein S11; Validated; Region: PRK05309 465515004859 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 465515004860 30S ribosomal protein S13; Region: bact_S13; TIGR03631 465515004861 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 465515004862 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 465515004863 rRNA binding site [nucleotide binding]; other site 465515004864 predicted 30S ribosome binding site; other site 465515004865 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 465515004866 active site 465515004867 adenylate kinase; Reviewed; Region: adk; PRK00279 465515004868 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 465515004869 AMP-binding site [chemical binding]; other site 465515004870 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 465515004871 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 465515004872 SecY translocase; Region: SecY; pfam00344 465515004873 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 465515004874 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 465515004875 23S rRNA binding site [nucleotide binding]; other site 465515004876 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 465515004877 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 465515004878 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 465515004879 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 465515004880 5S rRNA interface [nucleotide binding]; other site 465515004881 L27 interface [polypeptide binding]; other site 465515004882 23S rRNA interface [nucleotide binding]; other site 465515004883 L5 interface [polypeptide binding]; other site 465515004884 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 465515004885 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 465515004886 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 465515004887 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 465515004888 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 465515004889 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 465515004890 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 465515004891 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 465515004892 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 465515004893 RNA binding site [nucleotide binding]; other site 465515004894 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 465515004895 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 465515004896 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 465515004897 L23 interface [polypeptide binding]; other site 465515004898 signal recognition particle (SRP54) interaction site; other site 465515004899 trigger factor interaction site; other site 465515004900 23S rRNA interface [nucleotide binding]; other site 465515004901 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 465515004902 23S rRNA interface [nucleotide binding]; other site 465515004903 5S rRNA interface [nucleotide binding]; other site 465515004904 putative antibiotic binding site [chemical binding]; other site 465515004905 L25 interface [polypeptide binding]; other site 465515004906 L27 interface [polypeptide binding]; other site 465515004907 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 465515004908 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 465515004909 G-X-X-G motif; other site 465515004910 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 465515004911 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 465515004912 putative translocon binding site; other site 465515004913 protein-rRNA interface [nucleotide binding]; other site 465515004914 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 465515004915 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 465515004916 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 465515004917 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 465515004918 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 465515004919 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 465515004920 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 465515004921 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 465515004922 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 465515004923 elongation factor Tu; Reviewed; Region: PRK00049 465515004924 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 465515004925 G1 box; other site 465515004926 GEF interaction site [polypeptide binding]; other site 465515004927 GTP/Mg2+ binding site [chemical binding]; other site 465515004928 Switch I region; other site 465515004929 G2 box; other site 465515004930 G3 box; other site 465515004931 Switch II region; other site 465515004932 G4 box; other site 465515004933 G5 box; other site 465515004934 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 465515004935 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 465515004936 Antibiotic Binding Site [chemical binding]; other site 465515004937 elongation factor G; Reviewed; Region: PRK00007 465515004938 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 465515004939 G1 box; other site 465515004940 putative GEF interaction site [polypeptide binding]; other site 465515004941 GTP/Mg2+ binding site [chemical binding]; other site 465515004942 Switch I region; other site 465515004943 G2 box; other site 465515004944 G3 box; other site 465515004945 Switch II region; other site 465515004946 G4 box; other site 465515004947 G5 box; other site 465515004948 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 465515004949 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 465515004950 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 465515004951 30S ribosomal protein S7; Validated; Region: PRK05302 465515004952 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 465515004953 S17 interaction site [polypeptide binding]; other site 465515004954 S8 interaction site; other site 465515004955 16S rRNA interaction site [nucleotide binding]; other site 465515004956 streptomycin interaction site [chemical binding]; other site 465515004957 23S rRNA interaction site [nucleotide binding]; other site 465515004958 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 465515004959 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 465515004960 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 465515004961 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 465515004962 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 465515004963 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 465515004964 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 465515004965 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 465515004966 G-loop; other site 465515004967 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 465515004968 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 465515004969 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 465515004970 DNA binding site [nucleotide binding] 465515004971 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 465515004972 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 465515004973 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 465515004974 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 465515004975 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 465515004976 RPB10 interaction site [polypeptide binding]; other site 465515004977 RPB1 interaction site [polypeptide binding]; other site 465515004978 RPB11 interaction site [polypeptide binding]; other site 465515004979 RPB3 interaction site [polypeptide binding]; other site 465515004980 RPB12 interaction site [polypeptide binding]; other site 465515004981 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 465515004982 L11 interface [polypeptide binding]; other site 465515004983 putative EF-Tu interaction site [polypeptide binding]; other site 465515004984 putative EF-G interaction site [polypeptide binding]; other site 465515004985 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 465515004986 23S rRNA interface [nucleotide binding]; other site 465515004987 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 465515004988 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 465515004989 mRNA/rRNA interface [nucleotide binding]; other site 465515004990 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 465515004991 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 465515004992 23S rRNA interface [nucleotide binding]; other site 465515004993 putative thiostrepton binding site; other site 465515004994 L7/L12 interface [polypeptide binding]; other site 465515004995 L25 interface [polypeptide binding]; other site 465515004996 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 465515004997 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 465515004998 putative homodimer interface [polypeptide binding]; other site 465515004999 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 465515005000 heterodimer interface [polypeptide binding]; other site 465515005001 homodimer interface [polypeptide binding]; other site 465515005002 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 465515005003 aspartate aminotransferase; Provisional; Region: PRK05764 465515005004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465515005005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515005006 homodimer interface [polypeptide binding]; other site 465515005007 catalytic residue [active] 465515005008 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465515005009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465515005010 DNA binding residues [nucleotide binding] 465515005011 dimerization interface [polypeptide binding]; other site 465515005012 PspC domain; Region: PspC; cl00864 465515005013 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 465515005014 phosphofructokinase; Region: PFK_mixed; TIGR02483 465515005015 active site 465515005016 ADP/pyrophosphate binding site [chemical binding]; other site 465515005017 dimerization interface [polypeptide binding]; other site 465515005018 allosteric effector site; other site 465515005019 fructose-1,6-bisphosphate binding site; other site 465515005020 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 465515005021 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 465515005022 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 465515005023 heme-binding site [chemical binding]; other site 465515005024 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 465515005025 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515005026 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 465515005027 active site 465515005028 Ap6A binding site [chemical binding]; other site 465515005029 nudix motif; other site 465515005030 metal binding site [ion binding]; metal-binding site 465515005031 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465515005032 catalytic core [active] 465515005033 Predicted acetyltransferase [General function prediction only]; Region: COG2388 465515005034 thymidylate synthase; Reviewed; Region: thyA; PRK01827 465515005035 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 465515005036 dimerization interface [polypeptide binding]; other site 465515005037 active site 465515005038 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 465515005039 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 465515005040 folate binding site [chemical binding]; other site 465515005041 NADP+ binding site [chemical binding]; other site 465515005042 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 465515005043 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 465515005044 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 465515005045 FAD binding domain; Region: FAD_binding_4; pfam01565 465515005046 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 465515005047 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465515005048 active site 2 [active] 465515005049 active site 1 [active] 465515005050 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 465515005051 active site 465515005052 catalytic site [active] 465515005053 helicase 45; Provisional; Region: PTZ00424 465515005054 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 465515005055 ATP binding site [chemical binding]; other site 465515005056 Mg++ binding site [ion binding]; other site 465515005057 motif III; other site 465515005058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515005059 nucleotide binding region [chemical binding]; other site 465515005060 ATP-binding site [chemical binding]; other site 465515005061 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 465515005062 putative RNA binding site [nucleotide binding]; other site 465515005063 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 465515005064 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 465515005065 active site 465515005066 cystathionine gamma-synthase; Provisional; Region: PRK07811 465515005067 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 465515005068 homodimer interface [polypeptide binding]; other site 465515005069 substrate-cofactor binding pocket; other site 465515005070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515005071 catalytic residue [active] 465515005072 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 465515005073 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 465515005074 dimer interface [polypeptide binding]; other site 465515005075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515005076 catalytic residue [active] 465515005077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 465515005078 FOG: CBS domain [General function prediction only]; Region: COG0517 465515005079 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 465515005080 AMP-binding domain protein; Validated; Region: PRK08315 465515005081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515005082 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 465515005083 acyl-activating enzyme (AAE) consensus motif; other site 465515005084 putative AMP binding site [chemical binding]; other site 465515005085 putative active site [active] 465515005086 putative CoA binding site [chemical binding]; other site 465515005087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 465515005088 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 465515005089 enterobactin exporter EntS; Provisional; Region: PRK10489 465515005090 ferredoxin-NADP+ reductase; Region: PLN02852 465515005091 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515005092 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 465515005093 Predicted permeases [General function prediction only]; Region: RarD; COG2962 465515005094 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 465515005095 nucleotide binding site/active site [active] 465515005096 HIT family signature motif; other site 465515005097 catalytic residue [active] 465515005098 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 465515005099 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 465515005100 substrate binding pocket [chemical binding]; other site 465515005101 chain length determination region; other site 465515005102 substrate-Mg2+ binding site; other site 465515005103 catalytic residues [active] 465515005104 aspartate-rich region 1; other site 465515005105 active site lid residues [active] 465515005106 aspartate-rich region 2; other site 465515005107 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 465515005108 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 465515005109 dimer interface [polypeptide binding]; other site 465515005110 tetramer interface [polypeptide binding]; other site 465515005111 PYR/PP interface [polypeptide binding]; other site 465515005112 TPP binding site [chemical binding]; other site 465515005113 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 465515005114 TPP-binding site; other site 465515005115 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 465515005116 O-succinylbenzoate synthase; Provisional; Region: PRK02901 465515005117 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 465515005118 metal binding site [ion binding]; metal-binding site 465515005119 substrate binding pocket [chemical binding]; other site 465515005120 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 465515005121 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465515005122 E3 interaction surface; other site 465515005123 lipoyl attachment site [posttranslational modification]; other site 465515005124 e3 binding domain; Region: E3_binding; pfam02817 465515005125 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 465515005126 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 465515005127 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 465515005128 TPP binding site [chemical binding]; other site 465515005129 alpha subunit interface [polypeptide binding]; other site 465515005130 heterodimer interface [polypeptide binding]; other site 465515005131 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 465515005132 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 465515005133 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 465515005134 tetramer interface [polypeptide binding]; other site 465515005135 TPP-binding site [chemical binding]; other site 465515005136 heterodimer interface [polypeptide binding]; other site 465515005137 phosphorylation loop region [posttranslational modification] 465515005138 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 465515005139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465515005140 putative DNA binding site [nucleotide binding]; other site 465515005141 putative Zn2+ binding site [ion binding]; other site 465515005142 AsnC family; Region: AsnC_trans_reg; pfam01037 465515005143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515005144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465515005145 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 465515005146 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 465515005147 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 465515005148 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 465515005149 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 465515005150 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 465515005151 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 465515005152 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 465515005153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465515005154 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 465515005155 substrate binding site [chemical binding]; other site 465515005156 oxyanion hole (OAH) forming residues; other site 465515005157 trimer interface [polypeptide binding]; other site 465515005158 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 465515005159 TrkA-C domain; Region: TrkA_C; pfam02080 465515005160 TrkA-C domain; Region: TrkA_C; pfam02080 465515005161 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 465515005162 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 465515005163 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515005164 AMP binding site [chemical binding]; other site 465515005165 active site 465515005166 acyl-activating enzyme (AAE) consensus motif; other site 465515005167 CoA binding site [chemical binding]; other site 465515005168 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 465515005169 UbiA prenyltransferase family; Region: UbiA; pfam01040 465515005170 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 465515005171 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 465515005172 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 465515005173 ResB-like family; Region: ResB; pfam05140 465515005174 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 465515005175 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 465515005176 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 465515005177 catalytic residues [active] 465515005178 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465515005179 catalytic core [active] 465515005180 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 465515005181 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 465515005182 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 465515005183 active site 465515005184 Zn binding site [ion binding]; other site 465515005185 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 465515005186 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 465515005187 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 465515005188 TrkA-N domain; Region: TrkA_N; pfam02254 465515005189 TrkA-C domain; Region: TrkA_C; pfam02080 465515005190 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 465515005191 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 465515005192 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 465515005193 AP (apurinic/apyrimidinic) site pocket; other site 465515005194 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 465515005195 Metal-binding active site; metal-binding site 465515005196 exopolyphosphatase; Region: exo_poly_only; TIGR03706 465515005197 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 465515005198 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 465515005199 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 465515005200 active site 465515005201 interdomain interaction site; other site 465515005202 putative metal-binding site [ion binding]; other site 465515005203 nucleotide binding site [chemical binding]; other site 465515005204 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 465515005205 domain I; other site 465515005206 phosphate binding site [ion binding]; other site 465515005207 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 465515005208 domain II; other site 465515005209 domain III; other site 465515005210 nucleotide binding site [chemical binding]; other site 465515005211 DNA binding groove [nucleotide binding] 465515005212 catalytic site [active] 465515005213 domain IV; other site 465515005214 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 465515005215 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 465515005216 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 465515005217 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 465515005218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515005219 S-adenosylmethionine binding site [chemical binding]; other site 465515005220 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 465515005221 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 465515005222 active site residue [active] 465515005223 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515005224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515005225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465515005226 Coenzyme A binding pocket [chemical binding]; other site 465515005227 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 465515005228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515005229 ATP binding site [chemical binding]; other site 465515005230 putative Mg++ binding site [ion binding]; other site 465515005231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515005232 nucleotide binding region [chemical binding]; other site 465515005233 ATP-binding site [chemical binding]; other site 465515005234 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 465515005235 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 465515005236 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 465515005237 Walker A motif; other site 465515005238 hexamer interface [polypeptide binding]; other site 465515005239 ATP binding site [chemical binding]; other site 465515005240 Walker B motif; other site 465515005241 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 465515005242 putative active site [active] 465515005243 putative CoA binding site [chemical binding]; other site 465515005244 nudix motif; other site 465515005245 metal binding site [ion binding]; metal-binding site 465515005246 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 465515005247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 465515005248 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 465515005249 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 465515005250 minor groove reading motif; other site 465515005251 helix-hairpin-helix signature motif; other site 465515005252 substrate binding pocket [chemical binding]; other site 465515005253 active site 465515005254 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 465515005255 acetyl-CoA synthetase; Provisional; Region: PRK00174 465515005256 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 465515005257 active site 465515005258 CoA binding site [chemical binding]; other site 465515005259 acyl-activating enzyme (AAE) consensus motif; other site 465515005260 AMP binding site [chemical binding]; other site 465515005261 acetate binding site [chemical binding]; other site 465515005262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465515005263 DNA-binding site [nucleotide binding]; DNA binding site 465515005264 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 465515005265 Na2 binding site [ion binding]; other site 465515005266 putative substrate binding site 1 [chemical binding]; other site 465515005267 Na binding site 1 [ion binding]; other site 465515005268 putative substrate binding site 2 [chemical binding]; other site 465515005269 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 465515005270 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 465515005271 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 465515005272 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 465515005273 ligand binding site [chemical binding]; other site 465515005274 flexible hinge region; other site 465515005275 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 465515005276 putative switch regulator; other site 465515005277 non-specific DNA interactions [nucleotide binding]; other site 465515005278 DNA binding site [nucleotide binding] 465515005279 sequence specific DNA binding site [nucleotide binding]; other site 465515005280 putative cAMP binding site [chemical binding]; other site 465515005281 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 465515005282 homotrimer interaction site [polypeptide binding]; other site 465515005283 putative active site [active] 465515005284 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 465515005285 Helix-turn-helix domain; Region: HTH_28; pfam13518 465515005286 Winged helix-turn helix; Region: HTH_29; pfam13551 465515005287 HTH-like domain; Region: HTH_21; pfam13276 465515005288 Integrase core domain; Region: rve; pfam00665 465515005289 Integrase core domain; Region: rve_3; pfam13683 465515005290 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 465515005291 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 465515005292 Multicopper oxidase; Region: Cu-oxidase; pfam00394 465515005293 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 465515005294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465515005295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515005296 active site 465515005297 phosphorylation site [posttranslational modification] 465515005298 intermolecular recognition site; other site 465515005299 dimerization interface [polypeptide binding]; other site 465515005300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465515005301 DNA binding site [nucleotide binding] 465515005302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465515005303 dimerization interface [polypeptide binding]; other site 465515005304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465515005305 dimer interface [polypeptide binding]; other site 465515005306 phosphorylation site [posttranslational modification] 465515005307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515005308 ATP binding site [chemical binding]; other site 465515005309 Mg2+ binding site [ion binding]; other site 465515005310 G-X-G motif; other site 465515005311 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 465515005312 metal-binding site [ion binding] 465515005313 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 465515005314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 465515005315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515005316 motif I; other site 465515005317 motif II; other site 465515005318 Domain of unknown function (DUF305); Region: DUF305; pfam03713 465515005319 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 465515005320 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 465515005321 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 465515005322 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 465515005323 catalytic residue [active] 465515005324 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 465515005325 dimerization interface [polypeptide binding]; other site 465515005326 Winged helix-turn helix; Region: HTH_29; pfam13551 465515005327 Homeodomain-like domain; Region: HTH_23; cl17451 465515005328 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 465515005329 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515005330 MULE transposase domain; Region: MULE; pfam10551 465515005331 Transglycosylase; Region: Transgly; pfam00912 465515005332 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 465515005333 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 465515005334 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 465515005335 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 465515005336 putative active site [active] 465515005337 putative metal binding site [ion binding]; other site 465515005338 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 465515005339 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465515005340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515005341 Walker A/P-loop; other site 465515005342 ATP binding site [chemical binding]; other site 465515005343 Q-loop/lid; other site 465515005344 ABC transporter signature motif; other site 465515005345 Walker B; other site 465515005346 D-loop; other site 465515005347 H-loop/switch region; other site 465515005348 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 465515005349 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465515005350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515005351 Walker A/P-loop; other site 465515005352 ATP binding site [chemical binding]; other site 465515005353 Q-loop/lid; other site 465515005354 ABC transporter signature motif; other site 465515005355 Walker B; other site 465515005356 D-loop; other site 465515005357 H-loop/switch region; other site 465515005358 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 465515005359 ATP binding site [chemical binding]; other site 465515005360 active site 465515005361 substrate binding site [chemical binding]; other site 465515005362 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 465515005363 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 465515005364 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 465515005365 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 465515005366 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465515005367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515005368 active site 465515005369 phosphorylation site [posttranslational modification] 465515005370 intermolecular recognition site; other site 465515005371 dimerization interface [polypeptide binding]; other site 465515005372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465515005373 dimerization interface [polypeptide binding]; other site 465515005374 DNA binding residues [nucleotide binding] 465515005375 Histidine kinase; Region: HisKA_3; pfam07730 465515005376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515005377 ATP binding site [chemical binding]; other site 465515005378 G-X-G motif; other site 465515005379 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 465515005380 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465515005381 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 465515005382 Walker A/P-loop; other site 465515005383 ATP binding site [chemical binding]; other site 465515005384 Q-loop/lid; other site 465515005385 ABC transporter signature motif; other site 465515005386 Walker B; other site 465515005387 D-loop; other site 465515005388 H-loop/switch region; other site 465515005389 L-asparaginase II; Region: Asparaginase_II; pfam06089 465515005390 amidophosphoribosyltransferase; Provisional; Region: PRK07847 465515005391 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 465515005392 active site 465515005393 tetramer interface [polypeptide binding]; other site 465515005394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465515005395 active site 465515005396 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 465515005397 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 465515005398 dimerization interface [polypeptide binding]; other site 465515005399 putative ATP binding site [chemical binding]; other site 465515005400 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 465515005401 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 465515005402 NAD-dependent deacetylase; Provisional; Region: PRK05333 465515005403 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 465515005404 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 465515005405 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 465515005406 Clp amino terminal domain; Region: Clp_N; pfam02861 465515005407 Clp amino terminal domain; Region: Clp_N; pfam02861 465515005408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515005409 Walker A motif; other site 465515005410 ATP binding site [chemical binding]; other site 465515005411 Walker B motif; other site 465515005412 arginine finger; other site 465515005413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465515005414 Walker A motif; other site 465515005415 ATP binding site [chemical binding]; other site 465515005416 Walker B motif; other site 465515005417 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 465515005418 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 465515005419 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 465515005420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465515005421 substrate binding pocket [chemical binding]; other site 465515005422 membrane-bound complex binding site; other site 465515005423 hinge residues; other site 465515005424 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 465515005425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515005426 dimer interface [polypeptide binding]; other site 465515005427 conserved gate region; other site 465515005428 putative PBP binding loops; other site 465515005429 ABC-ATPase subunit interface; other site 465515005430 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 465515005431 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465515005432 Walker A/P-loop; other site 465515005433 ATP binding site [chemical binding]; other site 465515005434 Q-loop/lid; other site 465515005435 ABC transporter signature motif; other site 465515005436 Walker B; other site 465515005437 D-loop; other site 465515005438 H-loop/switch region; other site 465515005439 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 465515005440 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 465515005441 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 465515005442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515005443 S-adenosylmethionine binding site [chemical binding]; other site 465515005444 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 465515005445 DNA binding residues [nucleotide binding] 465515005446 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 465515005447 putative dimer interface [polypeptide binding]; other site 465515005448 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 465515005449 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 465515005450 HSP70 interaction site [polypeptide binding]; other site 465515005451 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 465515005452 substrate binding site [polypeptide binding]; other site 465515005453 dimer interface [polypeptide binding]; other site 465515005454 GrpE; Region: GrpE; pfam01025 465515005455 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 465515005456 dimer interface [polypeptide binding]; other site 465515005457 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 465515005458 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 465515005459 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 465515005460 nucleotide binding site [chemical binding]; other site 465515005461 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 465515005462 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 465515005463 dimerization interface [polypeptide binding]; other site 465515005464 DPS ferroxidase diiron center [ion binding]; other site 465515005465 ion pore; other site 465515005466 Transport protein; Region: actII; TIGR00833 465515005467 MMPL family; Region: MMPL; pfam03176 465515005468 MarR family; Region: MarR_2; cl17246 465515005469 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 465515005470 hypothetical protein; Provisional; Region: PRK06547 465515005471 chromosome segregation protein; Provisional; Region: PRK02224 465515005472 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 465515005473 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 465515005474 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 465515005475 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 465515005476 substrate-cofactor binding pocket; other site 465515005477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515005478 catalytic residue [active] 465515005479 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 465515005480 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 465515005481 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 465515005482 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 465515005483 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 465515005484 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 465515005485 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 465515005486 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 465515005487 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 465515005488 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 465515005489 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 465515005490 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 465515005491 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 465515005492 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 465515005493 trimer interface [polypeptide binding]; other site 465515005494 active site 465515005495 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 465515005496 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 465515005497 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 465515005498 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 465515005499 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 465515005500 Membrane transport protein; Region: Mem_trans; cl09117 465515005501 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 465515005502 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 465515005503 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 465515005504 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 465515005505 Copper resistance protein D; Region: CopD; pfam05425 465515005506 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 465515005507 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 465515005508 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 465515005509 Protein of unknown function (DUF461); Region: DUF461; pfam04314 465515005510 CopC domain; Region: CopC; pfam04234 465515005511 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 465515005512 IHF dimer interface [polypeptide binding]; other site 465515005513 IHF - DNA interface [nucleotide binding]; other site 465515005514 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 465515005515 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 465515005516 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 465515005517 CCC1-related family of proteins; Region: CCC1_like; cl00278 465515005518 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 465515005519 hypothetical protein; Provisional; Region: PRK05463 465515005520 Transcriptional regulators [Transcription]; Region: GntR; COG1802 465515005521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465515005522 DNA-binding site [nucleotide binding]; DNA binding site 465515005523 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 465515005524 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465515005525 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465515005526 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 465515005527 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 465515005528 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 465515005529 carboxyltransferase (CT) interaction site; other site 465515005530 biotinylation site [posttranslational modification]; other site 465515005531 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 465515005532 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 465515005533 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 465515005534 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 465515005535 putative active site [active] 465515005536 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 465515005537 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 465515005538 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 465515005539 putative dimer interface [polypeptide binding]; other site 465515005540 N-terminal domain interface [polypeptide binding]; other site 465515005541 putative substrate binding pocket (H-site) [chemical binding]; other site 465515005542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 465515005543 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 465515005544 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 465515005545 histidinol dehydrogenase; Region: hisD; TIGR00069 465515005546 NAD binding site [chemical binding]; other site 465515005547 dimerization interface [polypeptide binding]; other site 465515005548 product binding site; other site 465515005549 substrate binding site [chemical binding]; other site 465515005550 zinc binding site [ion binding]; other site 465515005551 catalytic residues [active] 465515005552 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465515005553 RNA binding surface [nucleotide binding]; other site 465515005554 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465515005555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515005556 Walker A/P-loop; other site 465515005557 ATP binding site [chemical binding]; other site 465515005558 Q-loop/lid; other site 465515005559 ABC transporter signature motif; other site 465515005560 Walker B; other site 465515005561 D-loop; other site 465515005562 H-loop/switch region; other site 465515005563 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 465515005564 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 465515005565 DNA-binding site [nucleotide binding]; DNA binding site 465515005566 RNA-binding motif; other site 465515005567 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 465515005568 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 465515005569 active site 465515005570 FMN binding site [chemical binding]; other site 465515005571 substrate binding site [chemical binding]; other site 465515005572 3Fe-4S cluster binding site [ion binding]; other site 465515005573 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 465515005574 active site 465515005575 Proline dehydrogenase; Region: Pro_dh; cl03282 465515005576 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 465515005577 NAD(P) binding site [chemical binding]; other site 465515005578 catalytic residues [active] 465515005579 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 465515005580 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 465515005581 Domain of unknown function DUF20; Region: UPF0118; pfam01594 465515005582 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 465515005583 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 465515005584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515005585 dimer interface [polypeptide binding]; other site 465515005586 conserved gate region; other site 465515005587 putative PBP binding loops; other site 465515005588 ABC-ATPase subunit interface; other site 465515005589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 465515005590 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465515005591 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 465515005592 Walker A/P-loop; other site 465515005593 ATP binding site [chemical binding]; other site 465515005594 Q-loop/lid; other site 465515005595 ABC transporter signature motif; other site 465515005596 Walker B; other site 465515005597 D-loop; other site 465515005598 H-loop/switch region; other site 465515005599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515005600 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 465515005601 active site 465515005602 RNA/DNA hybrid binding site [nucleotide binding]; other site 465515005603 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 465515005604 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 465515005605 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 465515005606 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 465515005607 dimer interface [polypeptide binding]; other site 465515005608 active site 465515005609 acyl-CoA synthetase; Validated; Region: PRK08316 465515005610 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515005611 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 465515005612 acyl-activating enzyme (AAE) consensus motif; other site 465515005613 acyl-activating enzyme (AAE) consensus motif; other site 465515005614 putative AMP binding site [chemical binding]; other site 465515005615 putative active site [active] 465515005616 putative CoA binding site [chemical binding]; other site 465515005617 acyl-coenzyme A oxidase; Region: PLN02526 465515005618 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515005619 active site 465515005620 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 465515005621 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465515005622 substrate binding site [chemical binding]; other site 465515005623 oxyanion hole (OAH) forming residues; other site 465515005624 trimer interface [polypeptide binding]; other site 465515005625 RNA polymerase sigma factor; Provisional; Region: PRK05901 465515005626 Protein of unknown function DUF262; Region: DUF262; pfam03235 465515005627 Uncharacterized conserved protein [Function unknown]; Region: COG1479 465515005628 Protein of unknown function DUF262; Region: DUF262; pfam03235 465515005629 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 465515005630 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 465515005631 homodimer interface [polypeptide binding]; other site 465515005632 chemical substrate binding site [chemical binding]; other site 465515005633 oligomer interface [polypeptide binding]; other site 465515005634 metal binding site [ion binding]; metal-binding site 465515005635 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 465515005636 GIY-YIG motif/motif A; other site 465515005637 putative active site [active] 465515005638 putative metal binding site [ion binding]; other site 465515005639 Uncharacterized conserved protein [Function unknown]; Region: COG3410 465515005640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515005641 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515005642 PhoD-like phosphatase; Region: PhoD; pfam09423 465515005643 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 465515005644 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 465515005645 putative active site [active] 465515005646 putative metal binding site [ion binding]; other site 465515005647 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 465515005648 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 465515005649 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 465515005650 active site 465515005651 catalytic site [active] 465515005652 substrate binding site [chemical binding]; other site 465515005653 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 465515005654 active site 465515005655 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 465515005656 active site 465515005657 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 465515005658 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465515005659 putative ADP-binding pocket [chemical binding]; other site 465515005660 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 465515005661 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 465515005662 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 465515005663 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 465515005664 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 465515005665 Cysteine-rich domain; Region: CCG; pfam02754 465515005666 Cysteine-rich domain; Region: CCG; pfam02754 465515005667 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 465515005668 L-lactate permease; Region: Lactate_perm; cl00701 465515005669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465515005670 DNA-binding site [nucleotide binding]; DNA binding site 465515005671 transcriptional regulator NanR; Provisional; Region: PRK03837 465515005672 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 465515005673 Protein of unknown function (DUF456); Region: DUF456; pfam04306 465515005674 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 465515005675 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465515005676 putative DNA binding site [nucleotide binding]; other site 465515005677 putative Zn2+ binding site [ion binding]; other site 465515005678 AsnC family; Region: AsnC_trans_reg; pfam01037 465515005679 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 465515005680 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 465515005681 hexamer interface [polypeptide binding]; other site 465515005682 ligand binding site [chemical binding]; other site 465515005683 putative active site [active] 465515005684 NAD(P) binding site [chemical binding]; other site 465515005685 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 465515005686 conserved cys residue [active] 465515005687 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 465515005688 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 465515005689 active site 465515005690 multimer interface [polypeptide binding]; other site 465515005691 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 465515005692 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 465515005693 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 465515005694 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465515005695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515005696 homodimer interface [polypeptide binding]; other site 465515005697 catalytic residue [active] 465515005698 hypothetical protein; Provisional; Region: PRK12764 465515005699 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 465515005700 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 465515005701 Transcriptional regulators [Transcription]; Region: GntR; COG1802 465515005702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465515005703 DNA-binding site [nucleotide binding]; DNA binding site 465515005704 FCD domain; Region: FCD; pfam07729 465515005705 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 465515005706 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 465515005707 NAD binding site [chemical binding]; other site 465515005708 catalytic residues [active] 465515005709 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 465515005710 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 465515005711 tetramer interface [polypeptide binding]; other site 465515005712 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 465515005713 tetramer interface [polypeptide binding]; other site 465515005714 active site 465515005715 metal binding site [ion binding]; metal-binding site 465515005716 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 465515005717 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 465515005718 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 465515005719 Uncharacterized conserved protein [Function unknown]; Region: COG0397 465515005720 hypothetical protein; Validated; Region: PRK00029 465515005721 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 465515005722 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 465515005723 [2Fe-2S] cluster binding site [ion binding]; other site 465515005724 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 465515005725 amidase catalytic site [active] 465515005726 Zn binding residues [ion binding]; other site 465515005727 substrate binding site [chemical binding]; other site 465515005728 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515005729 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515005730 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515005731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465515005732 HPP family; Region: HPP; pfam04982 465515005733 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 465515005734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465515005735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515005736 homodimer interface [polypeptide binding]; other site 465515005737 catalytic residue [active] 465515005738 Transcriptional regulator [Transcription]; Region: IclR; COG1414 465515005739 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 465515005740 phenol 2-monooxygenase; Provisional; Region: PRK08294 465515005741 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 465515005742 dimer interface [polypeptide binding]; other site 465515005743 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 465515005744 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 465515005745 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 465515005746 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 465515005747 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 465515005748 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 465515005749 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 465515005750 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 465515005751 FAD binding pocket [chemical binding]; other site 465515005752 FAD binding motif [chemical binding]; other site 465515005753 phosphate binding motif [ion binding]; other site 465515005754 beta-alpha-beta structure motif; other site 465515005755 NAD(p) ribose binding residues [chemical binding]; other site 465515005756 NAD binding pocket [chemical binding]; other site 465515005757 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 465515005758 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 465515005759 catalytic loop [active] 465515005760 iron binding site [ion binding]; other site 465515005761 enoyl-CoA hydratase; Provisional; Region: PRK06688 465515005762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465515005763 substrate binding site [chemical binding]; other site 465515005764 oxyanion hole (OAH) forming residues; other site 465515005765 trimer interface [polypeptide binding]; other site 465515005766 metabolite-proton symporter; Region: 2A0106; TIGR00883 465515005767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515005768 putative substrate translocation pore; other site 465515005769 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 465515005770 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 465515005771 dimer interface [polypeptide binding]; other site 465515005772 active site 465515005773 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 465515005774 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465515005775 substrate binding site [chemical binding]; other site 465515005776 oxyanion hole (OAH) forming residues; other site 465515005777 trimer interface [polypeptide binding]; other site 465515005778 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 465515005779 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 465515005780 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 465515005781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 465515005782 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 465515005783 hydrophobic ligand binding site; other site 465515005784 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 465515005785 tetramerization interface [polypeptide binding]; other site 465515005786 active site 465515005787 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 465515005788 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 465515005789 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 465515005790 substrate binding site [chemical binding]; other site 465515005791 dimer interface [polypeptide binding]; other site 465515005792 NADP binding site [chemical binding]; other site 465515005793 catalytic residues [active] 465515005794 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465515005795 active site 2 [active] 465515005796 active site 1 [active] 465515005797 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 465515005798 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 465515005799 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 465515005800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465515005801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515005802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515005803 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 465515005804 acyl-activating enzyme (AAE) consensus motif; other site 465515005805 AMP binding site [chemical binding]; other site 465515005806 active site 465515005807 CoA binding site [chemical binding]; other site 465515005808 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 465515005809 CoenzymeA binding site [chemical binding]; other site 465515005810 subunit interaction site [polypeptide binding]; other site 465515005811 PHB binding site; other site 465515005812 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 465515005813 RNase_H superfamily; Region: RNase_H_2; pfam13482 465515005814 AAA domain; Region: AAA_30; pfam13604 465515005815 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 465515005816 AAA domain; Region: AAA_12; pfam13087 465515005817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515005818 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515005819 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465515005820 AMP-binding enzyme; Region: AMP-binding; pfam00501 465515005821 acyl-activating enzyme (AAE) consensus motif; other site 465515005822 active site 465515005823 AMP binding site [chemical binding]; other site 465515005824 CoA binding site [chemical binding]; other site 465515005825 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 465515005826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465515005827 adenylosuccinate lyase; Provisional; Region: PRK09285 465515005828 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 465515005829 tetramer interface [polypeptide binding]; other site 465515005830 AAA ATPase domain; Region: AAA_16; pfam13191 465515005831 Predicted membrane protein [Function unknown]; Region: COG2860 465515005832 UPF0126 domain; Region: UPF0126; pfam03458 465515005833 UPF0126 domain; Region: UPF0126; pfam03458 465515005834 Predicted membrane protein [Function unknown]; Region: COG2860 465515005835 UPF0126 domain; Region: UPF0126; pfam03458 465515005836 UPF0126 domain; Region: UPF0126; pfam03458 465515005837 hypothetical protein; Provisional; Region: PRK13663 465515005838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 465515005839 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 465515005840 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 465515005841 cofactor binding site; other site 465515005842 DNA binding site [nucleotide binding] 465515005843 substrate interaction site [chemical binding]; other site 465515005844 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 465515005845 active site 465515005846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515005847 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515005848 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 465515005849 CoA-transferase family III; Region: CoA_transf_3; pfam02515 465515005850 Protein of unknown function (DUF664); Region: DUF664; pfam04978 465515005851 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 465515005852 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 465515005853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515005854 motif II; other site 465515005855 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515005856 MULE transposase domain; Region: MULE; pfam10551 465515005857 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 465515005858 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 465515005859 AAA domain; Region: AAA_23; pfam13476 465515005860 Walker A/P-loop; other site 465515005861 ATP binding site [chemical binding]; other site 465515005862 ABC transporter; Region: ABC_tran; pfam00005 465515005863 Q-loop/lid; other site 465515005864 ABC transporter signature motif; other site 465515005865 Walker B; other site 465515005866 D-loop; other site 465515005867 H-loop/switch region; other site 465515005868 BioY family; Region: BioY; pfam02632 465515005869 Transposase, Mutator family; Region: Transposase_mut; pfam00872 465515005870 MULE transposase domain; Region: MULE; pfam10551 465515005871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465515005872 dimerization interface [polypeptide binding]; other site 465515005873 putative DNA binding site [nucleotide binding]; other site 465515005874 putative Zn2+ binding site [ion binding]; other site 465515005875 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 465515005876 arsenical-resistance protein; Region: acr3; TIGR00832 465515005877 Low molecular weight phosphatase family; Region: LMWPc; cl00105 465515005878 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 465515005879 active site 465515005880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 465515005881 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 465515005882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465515005883 dimerization interface [polypeptide binding]; other site 465515005884 putative DNA binding site [nucleotide binding]; other site 465515005885 putative Zn2+ binding site [ion binding]; other site 465515005886 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 465515005887 Cadmium resistance transporter; Region: Cad; pfam03596 465515005888 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 465515005889 dimanganese center [ion binding]; other site 465515005890 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465515005891 active site 465515005892 DNA binding site [nucleotide binding] 465515005893 Int/Topo IB signature motif; other site 465515005894 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 465515005895 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 465515005896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465515005897 active site 465515005898 DNA binding site [nucleotide binding] 465515005899 Int/Topo IB signature motif; other site 465515005900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515005901 NADH(P)-binding; Region: NAD_binding_10; pfam13460 465515005902 NAD(P) binding site [chemical binding]; other site 465515005903 active site 465515005904 Predicted transcriptional regulator [Transcription]; Region: COG1959 465515005905 Transcriptional regulator; Region: Rrf2; pfam02082 465515005906 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 465515005907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465515005908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465515005909 dimerization interface [polypeptide binding]; other site 465515005910 Lysine efflux permease [General function prediction only]; Region: COG1279 465515005911 Helix-turn-helix domain; Region: HTH_17; pfam12728 465515005912 methionine synthase; Provisional; Region: PRK01207 465515005913 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 465515005914 substrate binding site [chemical binding]; other site 465515005915 THF binding site; other site 465515005916 zinc-binding site [ion binding]; other site 465515005917 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 465515005918 cystathionine gamma-synthase; Provisional; Region: PRK07811 465515005919 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 465515005920 homodimer interface [polypeptide binding]; other site 465515005921 substrate-cofactor binding pocket; other site 465515005922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515005923 catalytic residue [active] 465515005924 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 465515005925 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 465515005926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465515005927 catalytic residue [active] 465515005928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515005929 S-adenosylmethionine binding site [chemical binding]; other site 465515005930 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 465515005931 active site 465515005932 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465515005933 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515005934 Protein of unknown function (DUF805); Region: DUF805; pfam05656 465515005935 Helix-turn-helix domain; Region: HTH_38; pfam13936 465515005936 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 465515005937 Integrase core domain; Region: rve; pfam00665 465515005938 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515005939 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515005940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465515005941 AAA domain; Region: AAA_17; pfam13207 465515005942 Methyltransferase domain; Region: Methyltransf_23; pfam13489 465515005943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515005944 S-adenosylmethionine binding site [chemical binding]; other site 465515005945 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 465515005946 nudix motif; other site 465515005947 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 465515005948 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 465515005949 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 465515005950 MarR family; Region: MarR_2; cl17246 465515005951 Transcriptional regulators [Transcription]; Region: MarR; COG1846 465515005952 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 465515005953 Protein of unknown function (DUF805); Region: DUF805; pfam05656 465515005954 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 465515005955 active site 465515005956 catalytic triad [active] 465515005957 oxyanion hole [active] 465515005958 PQQ-like domain; Region: PQQ_2; pfam13360 465515005959 aspartate aminotransferase; Provisional; Region: PRK05764 465515005960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465515005961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465515005962 homodimer interface [polypeptide binding]; other site 465515005963 catalytic residue [active] 465515005964 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 465515005965 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 465515005966 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465515005967 ATP binding site [chemical binding]; other site 465515005968 putative Mg++ binding site [ion binding]; other site 465515005969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465515005970 nucleotide binding region [chemical binding]; other site 465515005971 ATP-binding site [chemical binding]; other site 465515005972 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 465515005973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465515005974 NAD(P) binding site [chemical binding]; other site 465515005975 active site 465515005976 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 465515005977 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 465515005978 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 465515005979 active site 465515005980 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 465515005981 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 465515005982 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 465515005983 prenyltransferase; Reviewed; Region: ubiA; PRK13105 465515005984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 465515005985 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 465515005986 substrate binding pocket [chemical binding]; other site 465515005987 substrate-Mg2+ binding site; other site 465515005988 aspartate-rich region 1; other site 465515005989 aspartate-rich region 2; other site 465515005990 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 465515005991 substrate binding pocket [chemical binding]; other site 465515005992 aspartate-rich region 1; other site 465515005993 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 465515005994 substrate binding pocket [chemical binding]; other site 465515005995 aspartate-rich region 2; other site 465515005996 substrate-Mg2+ binding site; other site 465515005997 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 465515005998 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 465515005999 active site 465515006000 metal binding site [ion binding]; metal-binding site 465515006001 nudix motif; other site 465515006002 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 465515006003 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 465515006004 catalytic residues [active] 465515006005 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 465515006006 Dehydroquinase class II; Region: DHquinase_II; pfam01220 465515006007 trimer interface [polypeptide binding]; other site 465515006008 active site 465515006009 dimer interface [polypeptide binding]; other site 465515006010 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 465515006011 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 465515006012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465515006013 FeS/SAM binding site; other site 465515006014 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 465515006015 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 465515006016 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 465515006017 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 465515006018 Low molecular weight phosphatase family; Region: LMWPc; cl00105 465515006019 active site 465515006020 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 465515006021 putative homodimer interface [polypeptide binding]; other site 465515006022 putative homotetramer interface [polypeptide binding]; other site 465515006023 putative allosteric switch controlling residues; other site 465515006024 putative metal binding site [ion binding]; other site 465515006025 putative homodimer-homodimer interface [polypeptide binding]; other site 465515006026 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 465515006027 metal-binding site [ion binding] 465515006028 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 465515006029 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 465515006030 metal-binding site [ion binding] 465515006031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 465515006032 Soluble P-type ATPase [General function prediction only]; Region: COG4087 465515006033 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 465515006034 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 465515006035 putative hydrophobic ligand binding site [chemical binding]; other site 465515006036 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 465515006037 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 465515006038 CoenzymeA binding site [chemical binding]; other site 465515006039 subunit interaction site [polypeptide binding]; other site 465515006040 PHB binding site; other site 465515006041 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 465515006042 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 465515006043 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 465515006044 NAD binding site [chemical binding]; other site 465515006045 substrate binding site [chemical binding]; other site 465515006046 catalytic Zn binding site [ion binding]; other site 465515006047 tetramer interface [polypeptide binding]; other site 465515006048 structural Zn binding site [ion binding]; other site 465515006049 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 465515006050 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 465515006051 NAD(P) binding site [chemical binding]; other site 465515006052 catalytic residues [active] 465515006053 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 465515006054 Protein of unknown function (DUF779); Region: DUF779; pfam05610 465515006055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465515006056 thiamine pyrophosphate protein; Validated; Region: PRK08199 465515006057 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 465515006058 PYR/PP interface [polypeptide binding]; other site 465515006059 dimer interface [polypeptide binding]; other site 465515006060 TPP binding site [chemical binding]; other site 465515006061 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465515006062 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 465515006063 TPP-binding site [chemical binding]; other site 465515006064 CGNR zinc finger; Region: zf-CGNR; pfam11706 465515006065 Homeodomain-like domain; Region: HTH_23; cl17451 465515006066 Winged helix-turn helix; Region: HTH_29; pfam13551 465515006067 Integrase core domain; Region: rve; pfam00665 465515006068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 465515006069 Integrase core domain; Region: rve_3; pfam13683 465515006070 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 465515006071 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 465515006072 LDH/MDH dimer interface [polypeptide binding]; other site 465515006073 NAD(P) binding site [chemical binding]; other site 465515006074 substrate binding site [chemical binding]; other site 465515006075 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 465515006076 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 465515006077 CAAX protease self-immunity; Region: Abi; pfam02517 465515006078 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 465515006079 active site 465515006080 metal binding site [ion binding]; metal-binding site 465515006081 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 465515006082 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 465515006083 Sulfate transporter family; Region: Sulfate_transp; pfam00916 465515006084 Sulfate transporter family; Region: Sulfate_transp; pfam00916 465515006085 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 465515006086 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 465515006087 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465515006088 Walker A/P-loop; other site 465515006089 ATP binding site [chemical binding]; other site 465515006090 Q-loop/lid; other site 465515006091 ABC transporter signature motif; other site 465515006092 Walker B; other site 465515006093 D-loop; other site 465515006094 H-loop/switch region; other site 465515006095 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 465515006096 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465515006097 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 465515006098 Walker A/P-loop; other site 465515006099 ATP binding site [chemical binding]; other site 465515006100 Q-loop/lid; other site 465515006101 ABC transporter signature motif; other site 465515006102 Walker B; other site 465515006103 D-loop; other site 465515006104 H-loop/switch region; other site 465515006105 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465515006106 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 465515006107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515006108 Walker A/P-loop; other site 465515006109 ATP binding site [chemical binding]; other site 465515006110 Q-loop/lid; other site 465515006111 ABC transporter signature motif; other site 465515006112 Walker B; other site 465515006113 D-loop; other site 465515006114 H-loop/switch region; other site 465515006115 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 465515006116 putative homodimer interface [polypeptide binding]; other site 465515006117 putative homotetramer interface [polypeptide binding]; other site 465515006118 putative allosteric switch controlling residues; other site 465515006119 putative metal binding site [ion binding]; other site 465515006120 putative homodimer-homodimer interface [polypeptide binding]; other site 465515006121 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 465515006122 active site residue [active] 465515006123 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 465515006124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 465515006125 active site residue [active] 465515006126 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 465515006127 PLD-like domain; Region: PLDc_2; pfam13091 465515006128 putative active site [active] 465515006129 catalytic site [active] 465515006130 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 465515006131 PLD-like domain; Region: PLDc_2; pfam13091 465515006132 putative active site [active] 465515006133 catalytic site [active] 465515006134 active site 2 [active] 465515006135 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465515006136 active site 1 [active] 465515006137 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465515006138 active site 2 [active] 465515006139 active site 1 [active] 465515006140 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 465515006141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515006142 S-adenosylmethionine binding site [chemical binding]; other site 465515006143 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 465515006144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465515006145 motif II; other site 465515006146 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 465515006147 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 465515006148 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 465515006149 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 465515006150 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 465515006151 Transposase; Region: DEDD_Tnp_IS110; pfam01548 465515006152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 465515006153 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 465515006154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515006155 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 465515006156 Walker A/P-loop; other site 465515006157 ATP binding site [chemical binding]; other site 465515006158 Q-loop/lid; other site 465515006159 ABC transporter signature motif; other site 465515006160 Walker B; other site 465515006161 D-loop; other site 465515006162 H-loop/switch region; other site 465515006163 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515006164 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 465515006165 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 465515006166 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515006167 Bacterial PH domain; Region: DUF304; pfam03703 465515006168 Bacterial PH domain; Region: DUF304; pfam03703 465515006169 Histidine kinase; Region: HisKA_3; pfam07730 465515006170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465515006171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515006172 active site 465515006173 phosphorylation site [posttranslational modification] 465515006174 intermolecular recognition site; other site 465515006175 dimerization interface [polypeptide binding]; other site 465515006176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465515006177 dimerization interface [polypeptide binding]; other site 465515006178 DNA binding residues [nucleotide binding] 465515006179 Histidine kinase; Region: HisKA_3; pfam07730 465515006180 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 465515006181 L-lactate permease; Region: Lactate_perm; cl00701 465515006182 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 465515006183 phosphate binding site [ion binding]; other site 465515006184 Histidine kinase; Region: HisKA_3; pfam07730 465515006185 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 465515006186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465515006187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515006188 active site 465515006189 phosphorylation site [posttranslational modification] 465515006190 intermolecular recognition site; other site 465515006191 dimerization interface [polypeptide binding]; other site 465515006192 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465515006193 DNA binding residues [nucleotide binding] 465515006194 dimerization interface [polypeptide binding]; other site 465515006195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465515006196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515006197 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465515006198 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 465515006199 Walker A/P-loop; other site 465515006200 ATP binding site [chemical binding]; other site 465515006201 Q-loop/lid; other site 465515006202 ABC transporter signature motif; other site 465515006203 Walker B; other site 465515006204 D-loop; other site 465515006205 H-loop/switch region; other site 465515006206 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 465515006207 FtsX-like permease family; Region: FtsX; pfam02687 465515006208 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 465515006209 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 465515006210 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 465515006211 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 465515006212 Sodium Bile acid symporter family; Region: SBF; cl17470 465515006213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 465515006214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465515006215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515006216 Walker A/P-loop; other site 465515006217 ATP binding site [chemical binding]; other site 465515006218 Q-loop/lid; other site 465515006219 ABC transporter signature motif; other site 465515006220 Walker B; other site 465515006221 D-loop; other site 465515006222 H-loop/switch region; other site 465515006223 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 465515006224 nudix motif; other site 465515006225 LysE type translocator; Region: LysE; cl00565 465515006226 LysE type translocator; Region: LysE; cl00565 465515006227 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 465515006228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465515006229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465515006230 dimerization interface [polypeptide binding]; other site 465515006231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 465515006232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465515006233 dimer interface [polypeptide binding]; other site 465515006234 phosphorylation site [posttranslational modification] 465515006235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465515006236 ATP binding site [chemical binding]; other site 465515006237 Mg2+ binding site [ion binding]; other site 465515006238 G-X-G motif; other site 465515006239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465515006240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465515006241 active site 465515006242 phosphorylation site [posttranslational modification] 465515006243 intermolecular recognition site; other site 465515006244 dimerization interface [polypeptide binding]; other site 465515006245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465515006246 DNA binding site [nucleotide binding] 465515006247 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 465515006248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465515006249 S-adenosylmethionine binding site [chemical binding]; other site 465515006250 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 465515006251 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 465515006252 siderophore binding site; other site 465515006253 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 465515006254 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 465515006255 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 465515006256 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 465515006257 Walker A/P-loop; other site 465515006258 ATP binding site [chemical binding]; other site 465515006259 Q-loop/lid; other site 465515006260 ABC transporter signature motif; other site 465515006261 Walker B; other site 465515006262 D-loop; other site 465515006263 H-loop/switch region; other site 465515006264 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 465515006265 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 465515006266 FAD binding pocket [chemical binding]; other site 465515006267 FAD binding motif [chemical binding]; other site 465515006268 phosphate binding motif [ion binding]; other site 465515006269 NAD binding pocket [chemical binding]; other site 465515006270 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 465515006271 NADH(P)-binding; Region: NAD_binding_10; pfam13460 465515006272 NAD(P) binding site [chemical binding]; other site 465515006273 putative active site [active] 465515006274 Glutaminase; Region: Glutaminase; cl00907 465515006275 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 465515006276 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 465515006277 Coenzyme A binding pocket [chemical binding]; other site 465515006278 LabA_like proteins; Region: LabA_like; cd06167 465515006279 putative metal binding site [ion binding]; other site 465515006280 Uncharacterized conserved protein [Function unknown]; Region: COG1432 465515006281 FAD binding domain; Region: FAD_binding_4; pfam01565 465515006282 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 465515006283 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 465515006284 active site 465515006285 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 465515006286 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 465515006287 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 465515006288 synthetase active site [active] 465515006289 NTP binding site [chemical binding]; other site 465515006290 metal binding site [ion binding]; metal-binding site 465515006291 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 465515006292 TIGR03086 family protein; Region: TIGR03086 465515006293 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 465515006294 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 465515006295 putative active site [active] 465515006296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 465515006297 Transposase; Region: DDE_Tnp_ISL3; pfam01610 465515006298 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 465515006299 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 465515006300 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515006301 Coenzyme A binding pocket [chemical binding]; other site 465515006302 Predicted membrane protein [Function unknown]; Region: COG1511 465515006303 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 465515006304 Predicted membrane protein [Function unknown]; Region: COG1511 465515006305 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 465515006306 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 465515006307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 465515006308 Walker A/P-loop; other site 465515006309 ATP binding site [chemical binding]; other site 465515006310 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465515006311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465515006312 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 465515006313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 465515006314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515006315 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 465515006316 Peptidase family M23; Region: Peptidase_M23; pfam01551 465515006317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465515006318 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465515006319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465515006320 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515006321 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 465515006322 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 465515006323 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 465515006324 FAD binding pocket [chemical binding]; other site 465515006325 FAD binding motif [chemical binding]; other site 465515006326 phosphate binding motif [ion binding]; other site 465515006327 beta-alpha-beta structure motif; other site 465515006328 NAD binding pocket [chemical binding]; other site 465515006329 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 465515006330 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 465515006331 catalytic loop [active] 465515006332 iron binding site [ion binding]; other site 465515006333 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 465515006334 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 465515006335 putative di-iron ligands [ion binding]; other site 465515006336 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 465515006337 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 465515006338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515006339 dimer interface [polypeptide binding]; other site 465515006340 conserved gate region; other site 465515006341 putative PBP binding loops; other site 465515006342 ABC-ATPase subunit interface; other site 465515006343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465515006344 dimer interface [polypeptide binding]; other site 465515006345 conserved gate region; other site 465515006346 putative PBP binding loops; other site 465515006347 ABC-ATPase subunit interface; other site 465515006348 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 465515006349 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 465515006350 Transcriptional regulators [Transcription]; Region: PurR; COG1609 465515006351 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465515006352 DNA binding site [nucleotide binding] 465515006353 domain linker motif; other site 465515006354 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 465515006355 dimerization interface [polypeptide binding]; other site 465515006356 ligand binding site [chemical binding]; other site 465515006357 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 465515006358 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 465515006359 Walker A/P-loop; other site 465515006360 ATP binding site [chemical binding]; other site 465515006361 Q-loop/lid; other site 465515006362 ABC transporter signature motif; other site 465515006363 Walker B; other site 465515006364 D-loop; other site 465515006365 H-loop/switch region; other site 465515006366 TOBE domain; Region: TOBE_2; pfam08402 465515006367 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 465515006368 putative hydrophobic ligand binding site [chemical binding]; other site 465515006369 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 465515006370 active site 465515006371 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515006372 Coenzyme A binding pocket [chemical binding]; other site 465515006373 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 465515006374 catalytic residues [active] 465515006375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 465515006376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 465515006377 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 465515006378 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 465515006379 catalytic residues [active] 465515006380 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 465515006381 aromatic arch; other site 465515006382 DCoH dimer interaction site [polypeptide binding]; other site 465515006383 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 465515006384 DCoH tetramer interaction site [polypeptide binding]; other site 465515006385 substrate binding site [chemical binding]; other site 465515006386 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 465515006387 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 465515006388 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 465515006389 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 465515006390 NAD(P) binding site [chemical binding]; other site 465515006391 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 465515006392 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 465515006393 potential catalytic triad [active] 465515006394 conserved cys residue [active] 465515006395 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 465515006396 hydroxyglutarate oxidase; Provisional; Region: PRK11728 465515006397 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 465515006398 iron-sulfur cluster [ion binding]; other site 465515006399 [2Fe-2S] cluster binding site [ion binding]; other site 465515006400 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 465515006401 active site 465515006402 metal binding site [ion binding]; metal-binding site 465515006403 oxidoreductase; Provisional; Region: PRK06128 465515006404 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 465515006405 NAD binding site [chemical binding]; other site 465515006406 metal binding site [ion binding]; metal-binding site 465515006407 active site 465515006408 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 465515006409 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 465515006410 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 465515006411 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 465515006412 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 465515006413 active site 465515006414 cystathionine gamma-lyase; Validated; Region: PRK07582 465515006415 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 465515006416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465515006417 catalytic residue [active] 465515006418 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 465515006419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515006420 Walker A/P-loop; other site 465515006421 ATP binding site [chemical binding]; other site 465515006422 Q-loop/lid; other site 465515006423 ABC transporter signature motif; other site 465515006424 Walker B; other site 465515006425 D-loop; other site 465515006426 H-loop/switch region; other site 465515006427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465515006428 Walker A/P-loop; other site 465515006429 ATP binding site [chemical binding]; other site 465515006430 ABC transporter; Region: ABC_tran; pfam00005 465515006431 Q-loop/lid; other site 465515006432 ABC transporter signature motif; other site 465515006433 Walker B; other site 465515006434 D-loop; other site 465515006435 H-loop/switch region; other site 465515006436 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 465515006437 hydrophobic ligand binding site; other site 465515006438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 465515006439 Protein of unknown function (DUF664); Region: DUF664; pfam04978 465515006440 DinB superfamily; Region: DinB_2; pfam12867 465515006441 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 465515006442 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 465515006443 DNA binding residues [nucleotide binding] 465515006444 drug binding residues [chemical binding]; other site 465515006445 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 465515006446 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 465515006447 CPxP motif; other site 465515006448 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 465515006449 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 465515006450 catalytic Zn binding site [ion binding]; other site 465515006451 NAD(P) binding site [chemical binding]; other site 465515006452 structural Zn binding site [ion binding]; other site 465515006453 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 465515006454 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 465515006455 acyl-activating enzyme (AAE) consensus motif; other site 465515006456 putative AMP binding site [chemical binding]; other site 465515006457 putative active site [active] 465515006458 putative CoA binding site [chemical binding]; other site 465515006459 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 465515006460 active site 465515006461 catalytic site [active] 465515006462 Zn binding site [ion binding]; other site 465515006463 tetramer interface [polypeptide binding]; other site 465515006464 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 465515006465 active site 465515006466 homotetramer interface [polypeptide binding]; other site 465515006467 homodimer interface [polypeptide binding]; other site 465515006468 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 465515006469 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 465515006470 DNA binding residues [nucleotide binding] 465515006471 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 465515006472 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 465515006473 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515006474 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 465515006475 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 465515006476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 465515006477 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 465515006478 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 465515006479 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 465515006480 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 465515006481 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 465515006482 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 465515006483 Transcriptional regulators [Transcription]; Region: GntR; COG1802 465515006484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465515006485 DNA-binding site [nucleotide binding]; DNA binding site 465515006486 FCD domain; Region: FCD; pfam07729 465515006487 Fic family protein [Function unknown]; Region: COG3177 465515006488 Fic/DOC family; Region: Fic; pfam02661 465515006489 MarR family; Region: MarR_2; pfam12802 465515006490 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 465515006491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465515006492 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465515006493 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 465515006494 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 465515006495 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 465515006496 amphipathic channel; other site 465515006497 Asn-Pro-Ala signature motifs; other site 465515006498 glycerol kinase; Provisional; Region: glpK; PRK00047 465515006499 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 465515006500 N- and C-terminal domain interface [polypeptide binding]; other site 465515006501 active site 465515006502 MgATP binding site [chemical binding]; other site 465515006503 catalytic site [active] 465515006504 metal binding site [ion binding]; metal-binding site 465515006505 putative homotetramer interface [polypeptide binding]; other site 465515006506 glycerol binding site [chemical binding]; other site 465515006507 homodimer interface [polypeptide binding]; other site 465515006508 potential frameshift: common BLAST hit: gi|145224883|ref|YP_001135561.1| excinuclease ABC subunit C 465515006509 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 465515006510 active site 465515006511 catalytic site [active] 465515006512 metal binding site [ion binding]; metal-binding site 465515006513 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 465515006514 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 465515006515 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 465515006516 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 465515006517 AIPR protein; Region: AIPR; pfam10592 465515006518 replicative DNA helicase; Region: DnaB; TIGR00665 465515006519 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 465515006520 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 465515006521 Walker A motif; other site 465515006522 ATP binding site [chemical binding]; other site 465515006523 Walker B motif; other site 465515006524 DNA binding loops [nucleotide binding] 465515006525 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 465515006526 CoA-transferase family III; Region: CoA_transf_3; pfam02515 465515006527 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465515006528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 465515006529 active site 465515006530 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 465515006531 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465515006532 TrkA-C domain; Region: TrkA_C; pfam02080 465515006533 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 465515006534 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 465515006535 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 465515006536 putative active site [active] 465515006537 Zn binding site [ion binding]; other site 465515006538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465515006539 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465515006540 putative substrate translocation pore; other site 465515006541 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 465515006542 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 465515006543 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 465515006544 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 465515006545 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 465515006546 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 465515006547 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 465515006548 dimer interface [polypeptide binding]; other site 465515006549 ssDNA binding site [nucleotide binding]; other site 465515006550 tetramer (dimer of dimers) interface [polypeptide binding]; other site 465515006551 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 465515006552 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 465515006553 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 465515006554 active site 465515006555 metal binding site [ion binding]; metal-binding site 465515006556 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 465515006557 Predicted integral membrane protein [Function unknown]; Region: COG5650 465515006558 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 465515006559 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 465515006560 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 465515006561 active site 465515006562 catalytic triad [active] 465515006563 oxyanion hole [active] 465515006564 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 465515006565 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 465515006566 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 465515006567 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 465515006568 active site 465515006569 NTP binding site [chemical binding]; other site 465515006570 metal binding triad [ion binding]; metal-binding site 465515006571 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 465515006572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 465515006573 Zn2+ binding site [ion binding]; other site 465515006574 Mg2+ binding site [ion binding]; other site 465515006575 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 465515006576 active site 465515006577 Ap6A binding site [chemical binding]; other site 465515006578 nudix motif; other site 465515006579 metal binding site [ion binding]; metal-binding site 465515006580 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 465515006581 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 465515006582 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 465515006583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465515006584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465515006585 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 465515006586 catalytic residues [active] 465515006587 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 465515006588 ParB-like nuclease domain; Region: ParBc; pfam02195 465515006589 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 465515006590 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 465515006591 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465515006592 Magnesium ion binding site [ion binding]; other site 465515006593 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 465515006594 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 465515006595 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 465515006596 G-X-X-G motif; other site 465515006597 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 465515006598 RxxxH motif; other site 465515006599 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 465515006600 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 465515006601 Haemolytic domain; Region: Haemolytic; pfam01809 465515006602 Ribonuclease P; Region: Ribonuclease_P; cl00457 465515006603 Ribosomal protein L34; Region: Ribosomal_L34; cl00370